WO2013094504A1 - Oral composition - Google Patents

Abstract

Provided is an oral composition in which the sensation of irritation caused by glycerophosphoric acid or a salt thereof is eliminated, astringency and peculiar taste are improved and a good feeling upon application is provided. An oral composition comprising (A) glycerophosphoric acid or a salt thereof and (B) glycyrrhizic acid or a salt thereof, said oral composition being characterized in that the (component (B))/(component (A)) ratio is 0.15 to 20 by mass. The oral composition may additionally contain (C) at least one component selected from vanilla absolute, vanillin, ethyl vanillin and nutmeg oil.

Description

Oral composition

The present invention relates to an oral composition particularly suitable as a liquid preparation, in which the irritant feeling of glycerophosphoric acid or a salt thereof is suppressed and the astringency and taste are improved, giving a good feeling of use.

Patent Document 1 (Japanese Patent Application Laid-Open No. 2005-47855) proposes that glycerophosphoric acid and its salt are effective in suppressing oral biofilms. Among these, calcium glycerophosphate is considered to increase calcium and phosphate concentrations in dental plaque to promote remineralization, prevent a marked decrease in plaque pH, and inhibit mutans bacteria metabolism.

However, glycerophosphoric acid and salts thereof have a sense of irritation, astringency and taste, and for this reason, oral compositions containing glycerophosphoric acid or salts thereof, particularly liquid oral compositions such as mouthwashes, There was a problem that the aftertaste was bad and the feeling of use was impaired.

Regarding the improvement of astringency and taste of glycerophosphoric acid and its salt, Patent Document 2 (Japanese Patent Laid-Open No. 2009-149560) contains glycero by adding raffinose and / or melibiose to calcium glycerophosphate and sodium monofluorophosphate. Although it has been proposed that the astringency and bitterness derived from calcium phosphate and sodium monofluorophosphate are suppressed, there is no indication regarding the irritation and its relaxation.

Further, Patent Document 3 (Japanese Patent Laid-Open No. 2010-215568) proposes a technique for reducing astringency, bitterness, and irritation by adding lactone and propylene glycol alginate to calcium glycerophosphate. However, this technique has a problem that the propylene glycol alginate becomes sticky, and there is room for improvement in the feeling of use. Moreover, there existed a subject that the kind of flavor which can be used was limited.

Japanese Patent Laying-Open No. 2005-47855 JP 2009-149560 A JP 2010-215568 A

Therefore, in the composition for oral cavity, suppression of the irritating feeling of glycerophosphoric acid and its salt and improvement of astringency and taste have been problems.
The present invention has been made in order to solve the above-mentioned problems, and provides an oral composition that gives a good feeling of use, with the irritant feeling of glycerophosphoric acid or a salt thereof being suppressed and the astringency and taste being improved. The purpose is to do.

As a result of intensive studies to achieve the above object, the present inventors have found that (A) glycerophosphoric acid or a salt thereof, (B) glycyrrhizic acid or a salt thereof, and component (B) / component (A) By combining and blending in a range of 0.15 to 20 as a mass ratio, especially in liquid oral compositions, the irritating feeling of glycerophosphoric acid or a salt thereof is suppressed, and astringency / taste is improved. It has been found that an oral composition giving a good feeling of use can be obtained.

Furthermore, it has been found that when one or more components selected from (C) vanilla absolute, vanillin, ethyl vanillin and nutmeg oil are blended, the above effects are enhanced and the usability is further enhanced.

Accordingly, the present invention provides the following oral composition.
[1] It contains (A) glycerophosphoric acid or a salt thereof and (B) glycyrrhizic acid or a salt thereof, and the component (B) / component (A) is 0.15 to 20 as a mass ratio. A composition for oral cavity.
[2] The oral composition according to [1], further comprising (C) one or more components selected from vanilla absolute, vanillin, ethyl vanillin and nutmeg oil.

According to the present invention, it is possible to provide an oral composition that suppresses the irritation of glycerophosphoric acid or a salt thereof, improves astringency and taste, and gives a good feeling of use.

Hereinafter, the present invention will be described in further detail. The composition for oral cavity of this invention contains (A) glycerophosphoric acid or its salt, and (B) glycyrrhizic acid or its salt.

Examples of the glycerophosphoric acid or salt thereof as component (A) include glycerophosphoric acid, alkali metal salts such as sodium salt and potassium salt thereof, and alkaline earth metal salts such as calcium salt. Two or more kinds can be mixed and blended. Among these, calcium glycerophosphate is more preferable from the viewpoint of effect expression.

Component (A) can be either a natural product or a synthetic product. For example, calcium glycerophosphate can be used from a natural product or a synthetic product. For example, a commercially available product such as a trade name “Calcium glycerophosphate” manufactured by Iwaki Pharmaceutical Co., Ltd. can be used.

The blending amount of component (A) is preferably 0.005 to 1% (mass%, hereinafter the same) of the total composition, more preferably 0.01 to 0.2%. The blending effect improves as the blending amount increases. However, when the blending amount exceeds 1%, the feeling of irritation, astringency and off-taste derived from the component (A) may become too strong and the usability may be impaired.

The component (B) glycyrrhizic acid or a salt thereof is a stimulant, astringent or unpleasant mitigating / suppressing agent derived from the component (A).
Examples of the component (B) glycyrrhizic acid or a salt thereof include glycyrrhizic acid, dipotassium glycyrrhizinate, tripotassium glycyrrhizinate, disodium glycyrrhizinate, trisodium glycyrrhizinate, monoammonium glycyrrhizinate, and diammonium glycyrrhizinate. Among these, dipotassium glycyrrhizinate is particularly preferable from the viewpoint of solubility in water and taste.
In the present invention, as a component (B), a plant containing glycyrrhizic acid or a salt thereof, for example, herbal medicine such as licorice or licorice extract can be blended.

The amount of glycyrrhizic acid or its salt is preferably 0.001 to 0.25%, more preferably 0.01 to 0.2% of the total composition. The greater the amount, the less the irritation and the better the astringency / taste. .

In the present invention, it is important for the expression of the effect that the components (A) and (B) are blended in an appropriate ratio. In this case, the component (B) / component (A) indicating the blending ratio of the components (A) and (B) is 0.15 to 20, and preferably 0.2 to 10, as a mass ratio. When the ratio is less than 0.15, the effect of suppressing the irritation of component (A) and improving the feeling of use (astringency and taste) are not sufficiently obtained. If it exceeds 20, the astringency, nasty taste, etc. of the component (B) itself become strong and the feeling of use is inferior.

The composition of the present invention preferably further contains (C) a component selected from vanilla absolute, vanillin, ethyl vanillin, and nutmeg oil. When a component (C) is mix | blended, the irritation | stimulation of a component (A), an astringent taste, and a nasty taste will be masked, and a usability | use_condition will improve more.

As the vanillin and ethyl vanillin, for example, commercially available products such as “Wanilin” manufactured by Toyoda Fragrance Co., Ltd., and “Ethyl Vanillin” manufactured by Kamata Fragrance Co., Ltd. can be used.

Vanilla absolute can be obtained, for example, by solvent extraction of vanilla beans by the following method. Commercial products can also be used.
Vanilla beans are extracted with an organic solvent (benzene, acetone, hexane, petroleum ether, etc.), and the solvent is distilled off (reduced pressure) to obtain vanilla oleoresin. This is extracted with a solvent (ethanol), cooled, the insoluble matter is filtered, and then the solvent is distilled off (reduced pressure) to obtain vanilla absolute. A solution diluted with a solvent such as ethanol, jojoba oil, or medium chain fatty acid ester can also be used.
As a commercial item, the brand name "Vanilla absolute (50% ethanol dilution product)" by the Kamata perfume company can be used, for example.

Nutmeg oil can be obtained by steam distillation of nutmeg seeds (Nutmeg, Nutaceae, scientific name: Myristica fragrance Hout.). A commercial item can also be used, for example, "Nutmeg Oil" manufactured by We Mann Fis Fragrance Co., Ltd. can be used.

Component (C) can be used alone or in combination of two or more of the above compounds. In particular, vanilla absolute alone or a combination of vanilla absolute and one or more selected from vanillin, ethyl vanillin, and nutmeg oil is preferable in terms of effect. When using 2 or more types together, the combined use of vanilla absolute and nutmeg oil is particularly preferable.

When the component (C) is blended, the blending amount is preferably 0.0000001 to 0.004%, more preferably 0.0000004 to 0.00075% of the entire composition. If it is less than 0.0000001%, the effect of alleviating irritation and improving the feeling of use may not be satisfactorily improved. If it exceeds 0.004%, the feeling of use may be impaired by the flavor of itself.

Component (C) / component (A) has a mass ratio of preferably 0.0000002 to 0.6, more preferably 0.000004 to 0.3, and still more preferably 0.000008 to 0.05. If it is less than 0.0000002, the usability improvement effect may not be sufficiently improved. When it exceeds 0.6, the flavor characteristic of component (C) itself may become strong and may be inferior to a feeling of use.

The composition of the present invention can further contain a cationic fungicide.
As the cationic disinfectant, one or more of cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride and the like can be used, and cetylpyridinium chloride and benzethonium chloride are particularly preferable, and chloride is particularly preferable in terms of usability. More preferred is cetylpyridinium.

When a cationic fungicide is blended, the blending amount is preferably 0.005 to 0.1%, more preferably 0.01 to 0.08% of the entire composition. If it is less than 0.005%, the blending effect may not be recognized. If it exceeds 0.1%, astringent taste and off-taste derived from the cationic fungicide may occur, and the feeling in use may be impaired.
Further, the blending amount of cetylpyridinium chloride is preferably 0.01 to 0.1%, more preferably 0.02 to 0.08% of the total composition.
The blending amount of benzethonium chloride is preferably 0.005 to 0.1%, more preferably 0.008 to 0.05% of the total composition.

The composition of the present invention is particularly suitably prepared as a liquid oral composition in which the blending components are solubilized. The composition of the present invention is also effective in paste-form preparations such as dentifrices. However, compared with such preparations, liquid preparations such as mouthwashes and liquid dentifrices are particularly irritating and astringent. -Although a nasty taste is strongly expressed, according to this invention, an irritation feeling can be relieved with such a liquid formulation, and astringency and taste can be suppressed. Specifically, it is prepared and applied as a mouthwash of the type that is used as it is, a freshener in the mouth, a mouthwash that is diluted at the time of use in a concentrated type, and a liquid dentifrice that is used by brushing with a toothbrush. And is particularly suitable as a mouthwash.

In addition to the above components, other known components can be blended in the composition of the present invention as necessary within a range that does not interfere with the effects of the present invention. Specifically, the liquid oral composition contains a wetting agent, a surfactant, a solvent, and if necessary, a sweetener, a coloring agent, a fragrance, an active ingredient, and the like. In addition, it is preferable that solid components which do not solubilize, such as an abrasive | polishing agent, are not normally mix | blended with a liquid oral composition, and an abrasive | polishing agent is not included.

Examples of the wetting agent include sugar alcohols such as sorbitol, malt, and lactit, and polyhydric alcohols such as glycerin, ethylene glycol, and polyethylene glycol. The blending amount of these wetting agents is preferably 2 to 20% of the total composition.

As the surfactant, known anionic surfactants, nonionic surfactants, cationic surfactants, and amphoteric surfactants can be blended, and it is particularly preferable to blend nonionic surfactants.

Examples of anionic surfactants include sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-acyl sarcosine such as sodium N-lauroyl sarcosine, sodium N-myristoyl sarcosine, sodium dodecylbenzenesulfonate, hydrogenated coconut fatty acid Sodium monoglyceride, sodium lauryl sulfoacetate, N-acyl glutamate such as sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acylalanine, sodium α-olefin sulfonate, etc. Is mentioned.

Nonionic surfactants include, for example, sugar alcohol fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester, maltitol fatty acid ester, lactol fatty acid ester, polyoxyethylene fatty acid ester such as polyoxyethylene hydrogenated castor oil, alkylol amide, Examples include polyoxyethylene sorbitan fatty acid ester, polyglycerin fatty acid ester, hexaglyceryl monocetylate, fatty acid diethanolamide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, and the like.

Nonionic surfactants include, in particular, polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100 moles, an average addition mole of ethylene oxide having an alkyl group having 16 (cetyl) to 18 (stearyl) carbon atoms. A polyoxyethylene alkyl ether having 20 to 40 moles, one kind selected from decaglycerin monofatty acid ester having a fatty acid having 12 (lauric acid) to 18 (stearic acid), particularly 12 to 14 (myristic acid) Two or more are preferred. Among them, polyoxyethylene hydrogenated castor oil is preferable in terms of sufficiently exerting the adhesion inhibitory effect of dental plaque on the tooth surface and appearance stability (no orientation), and in particular, the average added mole number of ethylene oxide is Those having 40 to 100 mol, particularly 60 to 100 mol are preferred. When the average added mole number of ethylene oxide is less than 40 moles, orientation is generated particularly in liquid preparations and stored at 50 ° C., and appearance stability (no orientation) may be impaired. Those exceeding 100 mol are generally not commercially available.
As the polyoxyethylene hydrogenated castor oil, commercially available products such as NIKKOL HCO system manufactured by Nikko Chemicals, Emarex HC system manufactured by Nihon Emulsion Co., Ltd., UNIOX HC system manufactured by NOF Corporation, and the like can be used.
As the polyoxyethylene alkyl ether, commercially available products such as Emarex 100 series and Emarex 600 series manufactured by Nikko Chemicals can be used.
As the decaglycerin monofatty acid ester, commercially available products such as NIKKOL Decagln series manufactured by Nikko Chemicals, Ryoto (registered trademark) polyglycerester D series manufactured by Mitsubishi Chemical Foods, Inc. can be used.

Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts. Amphoteric surfactants include betaine acetate-type amphoteric surfactants such as alkyldimethylaminoacetic acid betaines and fatty acid amidopropyldimethylaminoacetic acid betaines, and imidazoline types such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salts. Examples include amphoteric surfactants.
The blending amount of these surfactants is preferably 0.05 to 5% of the entire composition.

As a sweetening agent, xylitol, maltitol, saccharin, saccharin sodium, stevioside, aspartame and the like can be blended.
As a colorant, a highly safe water-soluble pigment such as Blue No. 1, Green No. 3, Yellow No. 4, Red No. 105, and the like can be added.

As a fragrance, natural essential oils such as peppermint oil, spearmint oil, eucalyptus oil, winter green oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, lavender oil and paracres oil, And l-menthol, l-carvone, orange oil, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, eugenol, menthyl acetate, citral, camphor, borneol, pinene, spirantol, etc. Perfume ingredients contained in natural essential oils, ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methyl phenyl glycidate, benzalde Perfume ingredients such as flavonol, furaneol, maltol, ethyl maltol, gamma / delta decalactone, gamma / deltown decalactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, ethylene glycol-l-menthyl carbonate, etc. Is a combination of several fragrance ingredients and natural essential oils. One of the blended flavors of apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, yogurt, etc. A seed | species or 2 or more types can be added in the range which does not prevent the effect of this invention. The addition amount is usually 0.00001 to 3% in the composition.

Active ingredients include, for example, bactericides such as isopropyl methyl cellulose, enzymes such as dextranase and mutanase, fluorides such as sodium fluoride and sodium monofluorophosphate, aluminum chlorohydroxy allantoin, allantoin, azulene, lysozyme chloride, ascorbic acid Such as vitamin C, dihydrocholesterol, glycyrrhetin salts, hydrocholesterol, chlorophyll, copper chlorophyllin sodium, thyme, ogon, clove, hamamelis, plant extracts, copper gluconate, caropeptide, sodium polyphosphate, water-soluble inorganic phosphate compounds Polyvinyl pyrrolidone, calculus inhibitor, dental plaque inhibitor, potassium nitrate, aluminum lactate and the like can be added. In addition, the addition amount of these active ingredients can be made into effective amount in the range which does not prevent the effect of this invention.

As the solvent, water is usually used, and the water content is preferably 60% or more of the total composition. Further, a lower monohydric alcohol such as ethanol may be blended within a range not impeding the effects of the present invention, but when added, it is preferably 10% or less of the entire composition. In addition, it is preferable not to mix | blend ethanol from the point of irritation | stimulation.

Hereinafter, although an Example, a comparative example, and a formulation example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Examples and Comparative Examples]
Liquid oral compositions having the compositions shown in Tables 1 to 3 were prepared by conventional methods and evaluated by the following methods. The results are shown in Tables 1 to 3.

(1) No sense of irritation The sample (liquid oral composition) contains about 10 ml in the mouth, rinsed for 30 seconds, and then evaluated for lack of irritation after mouthwash in the following 5 levels. Are indicated by ☆, ◎, ○, Δ, × in accordance with the following criteria.
Evaluation criteria for lack of irritation:
5 points: There was no irritation.
4 points: There was no irritation.
3 points: There was a slight irritation.
2 points: There was some irritation.
1 point: There was considerable irritation.
Criteria for lack of irritation:
☆: Average point 4.5 points or more and 5.0 points or less ◎: Average point 4.0 points or more and less than 4.5 points ○: Average point 3.0 points or more and less than 4.0 points △: Average point 2.0 points More than less than 3.0 points x: Average point less than 2.0 points

(2) Feeling of use (no astringency or taste)
About 10 ml of sample (liquid oral composition) is included in the mouth, rinsed for 30 seconds, and then evaluated for the astringency and unpleasantness after mouthwash in the following 5 levels. , ☆, ◎, ○, △, ×.
Evaluation criteria for astringency and tastelessness:
5 points: There was no astringency or taste, and the feeling of use was very good.
4 points: There was almost no astringency and unpleasant taste, and the feeling of use was good.
3 points: Slight astringency and a bitter taste, but there was no problem with the feeling of use.
2 points: Some astringency and nasty taste, slightly inferior to the feeling of use.
1 point: There was a lot of astringency and nasty taste, and the feeling of use was poor.
Judgment criteria for astringency and tastelessness:
☆: Average point 4.5 points or more and 5.0 points or less ◎: Average point 4.0 points or more and less than 4.5 points ○: Average point 3.0 points or more and less than 4.0 points △: Average point 2.0 points More than less than 3.0 points x: Average point less than 2.0 points

The details of the raw materials used are as follows.
Calcium glycerophosphate (Iwaki Pharmaceutical Co., Ltd.)
Dipotassium glycyrrhizinate (Maruzen Pharmaceutical Co., Ltd.)
β-Glycyrrhetinic acid (Maruzen Pharmaceutical Co., Ltd.)
Azulene sulfonate sodium (Alps Pharmaceutical Co., Ltd.)
Vanillin (made by Toyoda Fragrance)
Ethyl vanillin (manufactured by Iwata Inc.)
Vanilla absolute 50% diluted product (vanilla absolute (50% ethanol diluted product), manufactured by Iwata Inc.)
Nutmeg oil (manufactured by We Mann Fis Fragrance)
Cetylpyridinium chloride (manufactured by Wako Pure Chemical Industries, Ltd.)
Benzethonium chloride (Highamine 1622: Lonza Japan)
Polyoxyethylene (60) hardened castor oil, polyoxyethylene (100) hardened castor oil (manufactured by Nikko Chemicals)
Propylene glycol (Asahi Glass Co., Ltd.)
Glycerin (85%, Sakamoto Pharmaceutical Co., Ltd.)
Xylitol (Rocket Fleure)
Citric acid (manufactured by Komatsuya)
Sodium citrate (manufactured by Komatsuya)
Saccharin sodium (Daito Chemical Co., Ltd.)
Ethanol (Shinwa Alcohol)
As other ingredients, those conforming to the quasi-drug raw material standard 2006 were used.
The perfume composition is as shown in Tables 4 to 10 described later. The perfume composition A does not contain vanillin, ethyl vanillin, vanilla absolute, or nutmeg oil.

* 1; Figures in parentheses indicate the percentage of vanilla absolute pure product (the same applies hereinafter).

A prescription example is shown below. The oral compositions of these prescription examples all had a good feeling of use because the irritation of glycerophosphoric acid and its salts was suppressed, and the astringency and taste were improved.

[Prescription Example 1] Mouthwash (A) Calcium glycerophosphate 0.05
(B) Dipotassium glycyrrhizinate 0.015
(C) Vanilla absolute 50% diluted product 0.000004
(0.000002 ^{* 1} )
Cetylpyridinium chloride 0.05
Polyoxyethylene (100) hardened castor oil 0.5
Glycerin 4.5
Propylene glycol 3
Xylitol 3
Saccharin sodium 0.004
Fragrance composition A 0.2
Citric acid 0.03
Sodium citrate 0.25
Methyl paraoxybenzoate 0.1
Ethyl paraoxybenzoate 0.05
Purified water balance
Total 100.0%
(B) / (A) = 0.3

[Formulation Example 2] mouthwash (A) calcium glycerophosphate 0.05
(B) Dipotassium glycyrrhizinate 0.02
(C) Vanillin 0.000003
Cetylpyridinium chloride 0.05
Polyoxyethylene (60) hydrogenated castor oil 0.5
Glycerin 5
Propylene glycol 2.5
Xylitol 4
Saccharin sodium 0.002
Fragrance composition A 0.3
Citric acid 0.05
Sodium citrate 0.2
Methyl paraoxybenzoate 0.05
Ethyl paraoxybenzoate 0.1
Purified water balance
Total 100.0%
(B) / (A) = 0.4

[Prescription Example 3] Liquid Dentifrice (A) Calcium Glycerophosphate 0.03
(B) Dipotassium glycyrrhizinate 0.05
(C) Ethyl vanillin 0.0000008
Cetylpyridinium chloride 0.05
Lauroyl sarcosine sodium 0.1
Polyoxyethylene (100) hydrogenated castor oil 0.4
Glycerin 8
Propylene glycol 2
Xylitol 2.5
Erythritol 2.5
Sucralose 0.001
Fragrance composition A 0.15
Citric acid 0.04
Sodium citrate 0.3
Methyl paraoxybenzoate 0.08
Sodium benzoate 0.2
Purified water balance
Total 100.0%
(B) / (A) = 1.7

[Prescription Example 4] Liquid Dentifrice (A) Calcium Glycerophosphate 0.03
(B) Dipotassium glycyrrhizinate 0.2
(C) Vanilla absolute 50% diluted product 0.000001
(0.0000005 ^{* 1} )
(C) Nutmeg oil 0.0000005
Cetylpyridinium chloride 0.05
Isopropylmethylphenol 0.01
Sodium fluoride 0.1
Polyoxyethylene (60) hydrogenated castor oil 0.7
Glycerin 3
Propylene glycol 2
Polyethylene glycol 400 2
Xylitol 6
Saccharin sodium 0.001
Fragrance composition A 0.3
Citric acid 0.02
Sodium citrate 0.2
Methyl paraoxybenzoate 0.02
Ethyl paraoxybenzoate 0.05
Sodium benzoate 0.3
Purified water balance
Total 100.0%
(B) / (A) = 6.7

[Prescription Example 5] Mouthwash (A) Calcium glycerophosphate 0.05
(B) Dipotassium glycyrrhizinate 0.03
(C) Vanillin 0.0000003
(C) Nutmeg oil 0.0000003
Cetylpyridinium chloride 0.05
Benzethonium chloride 0.01
Sodium fluoride 0.1
Polyoxyethylene (100) hydrogenated castor oil 0.3
Glycerin 5
Propylene glycol 5
Erythritol 5
Xylitol 6
Saccharin sodium 0.002
Fragrance composition A 0.25
Citric acid 0.03
Sodium citrate 0.35
Methyl paraoxybenzoate 0.15
Ethyl paraoxybenzoate 0.01
Purified water balance
Total 100.0%
(B) / (A) = 0.6

[Prescription Example 6] Mouthwash (A) Calcium glycerophosphate 0.04
(B) Dipotassium glycyrrhizinate 0.15
(C) Vanilla absolute 50% diluted product 0.0000008
(0.0000004 ^{* 1} )
(C) Ethyl vanillin 0.0000001
Benzethonium chloride 0.07
Isopropylmethylphenol 0.01
Polyoxyethylene (60) hydrogenated castor oil 0.6
Glycerin 5
Polyethylene glycol 400 5
Xylitol 2
Erythritol 2
Sucralose 0.001
Fragrance composition A 0.3
Citric acid 0.01
Sodium citrate 0.3
Methyl paraoxybenzoate 0.1
Sodium benzoate 0.1
Purified water balance
Total 100.0%
(B) / (A) = 3.8

[Prescription Example 7] Liquid Dentifrice (A) Calcium Glycerophosphate 0.15
(B) Dipotassium glycyrrhizinate 0.1
(C) Nutmeg oil 0.0001
Benzethonium chloride 0.1
Sodium fluoride 0.1
Polyoxyethylene (100) hardened castor oil 0.5
Glycerin 4.5
Propylene glycol 3
Xylitol 2
Saccharin sodium 0.005
Fragrance composition A 0.2
Citric acid 0.03
Sodium citrate 0.25
Sodium benzoate 0.4
Purified water balance
Total 100.0%
(B) / (A) = 0.7

[Prescription Example 8] Liquid Dentifrice (Double-layer preparation)
Oil layer Tocopherol acetate 0.1
Liquid paraffin 25
Fragrance composition A 0.2
(C) Vanilla absolute 50% diluted product 0.000002
(0.000001 ^{* 1} )
Aqueous layer (A) Calcium glycerophosphate 0.05
(B) Dipotassium glycyrrhizinate 0.015
Glycerin 8
Propylene glycol 2
Sodium tripolyphosphate 0.3
Sodium carboxymethylcellulose 0.4
Xylitol 0.2
Saccharin sodium 0.001
Disodium hydrogen phosphate 0.5
Sodium dihydrogen phosphate 0.05
Methyl paraoxybenzoate 0.1
Sodium benzoate 0.2
Legal dyes (Red 106, 102, Blue 1, Green 3)
0.00002
Purified water balance
Total 100.0%
(B) / (A) = 0.3

[Prescription Example 9] Liquid dentifrice (double-layer preparation)
Oil layer Isopropylmethylphenol 0.001
Liquid paraffin 10
Tri (caprylic / capric) glyceryl 25
Fragrance composition A 0.3
(C) Vanillin 0.0000006
Aqueous layer (A) Calcium glycerophosphate 0.1
(B) Dipotassium glycyrrhizinate 0.1
Benzethonium chloride 0.002
Sodium fluoride 0.1
Glycerin 5
Propylene glycol 4
Sodium tripolyphosphate 0.5
Sodium pyrophosphate 0.1
Sodium carboxymethylcellulose 0.2
Hydroxyethyl cellulose 0.1
Xylitol 1
Sorbitol 2
Disodium hydrogen phosphate 0.7
Sodium dihydrogen phosphate 0.05
Methyl paraoxybenzoate 0.04
Sodium benzoate 0.4
Legal dyes (Red 106, 102, Blue 1, Green 3)
0.00004
Purified water balance
Total 100.0%
(B) / (A) = 1.0

[Prescription Example 10] Mouthwash (two-layer preparation)
Oil layer Liquid paraffin 30
Jojoba oil 5
Fragrance composition A 0.2
(C) Vanilla absolute 50% diluted product 0.0000006
(0.0000003 ^{* 1} )
(C) Nutmeg oil 0.0000005
Aqueous layer (A) Calcium glycerophosphate 0.03
(B) Dipotassium glycyrrhizinate 0.2
Cetylpyridinium chloride 0.001
Benzalkonium chloride 0.005
Epsilon aminocaproic acid 0.004
Glycerin 7
Propylene glycol 3
Sodium tripolyphosphate 0.2
Sodium pyrophosphate 0.5
Sodium carboxymethylcellulose 0.1
Hydroxypropyl cellulose 0.2
Xylitol 0.5
Disodium hydrogen phosphate 0.6
Sodium dihydrogen phosphate 0.07
Methyl paraoxybenzoate 0.07
Sodium benzoate 0.3
Legal dyes (Red 106, 102, Blue 1, Green 3)
0.00002
Purified water balance
Total 100.0%
(B) / (A) = 6.7

In the table, parts are parts by mass (the same applies hereinafter).

Claims (10)

1. An oral cavity characterized by containing (A) glycerophosphoric acid or a salt thereof and (B) glycyrrhizic acid or a salt thereof, wherein the component (B) / component (A) has a mass ratio of 0.15 to 20. Composition.
2. The composition for oral cavity according to claim 1, comprising 0.005 to 1% by mass of component (A) and 0.001 to 0.25% by mass of component (B).
3. The composition for oral cavity according to claim 1 or 2, wherein the component (A) is calcium glycerophosphate.
4. The composition for oral cavity according to claim 1, 2 or 3, wherein the component (B) is dipotassium glycyrrhizinate.
5. The oral composition according to any one of claims 1 to 4, further comprising (C) one or more components selected from vanilla absolute, vanillin, ethyl vanillin and nutmeg oil.
6. The oral composition according to any one of claims 1 to 5, further comprising 0.05 to 5% by mass of a nonionic surfactant.
7. The oral composition according to claim 6, wherein the nonionic surfactant is polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 40 to 100 moles.
8. The oral composition according to any one of claims 1 to 7, further comprising 2 to 20% by mass of a polyhydric alcohol.
9. The oral composition according to any one of claims 1 to 8, which is a liquid preparation.
10. (A) calcium glycerophosphate 0.005-1 mass%, (B) dipotassium glycyrrhizinate 0.001-0.25 mass%, component (B) / component (A) as a mass ratio A composition for liquid oral cavity, which is 0.15 to 20.