JP5825093B2 - Mouthwash composition - Google Patents

Description

  The present invention relates to a composition for oral cavity that is preferably prepared as a liquid preparation, in which an unpleasant sensation associated with sweetness perceived in the throat derived from glycyrrhizic acid or a salt thereof is eliminated, and the aftertaste is good.

Conventionally, various active ingredients are blended in oral compositions for the purpose of preventing and treating problems in the oral cavity. Various active ingredients that have anti-inflammatory effects, blood circulation promoting effects, tissue activation effects, etc. are used for the prevention and treatment of periodontal diseases, and among them, glycyrrhizic acid and its salts are high in active ingredients derived from natural products It has been widely used because it has an anti-inflammatory effect, etc. (Patent Document 1; JP 2009-107988 A, Patent Document 2; JP 8-40858 A, Patent Document 3; JP 61-286314 A). .
Glycyrrhizic acid and its salt have a sweetness 100 to 200 times that of sucrose, and are also used as high-intensity sweeteners (Patent Document 4; JP-A-60-130509).

  However, in oral compositions containing glycyrrhizic acid or a salt thereof, there is a sense of incongruity associated with the sweetness peculiar to high-intensity sweeteners derived from glycyrrhizic acid or a salt thereof after use and the sweetness felt in the throat after use. It was the cause of spoiling the sex. In particular, the liquid oral composition is 10 to 20 mL per use and 10 to 20 times the amount of the toothpaste, and easily spreads in the oral cavity and does not require water rinsing, so glycyrrhizic acid or its The salt tends to stay in the throat, so that the sense of incongruity associated with the sweetness felt in the throat after use is more strongly felt and the palatability is easily impaired.

  Among them, as a method for improving the sweetness peculiar to high sweetness, a method using a bitter substance such as a cyclic or linear terpene alcohol compound (menthol, linalool, citronellol, geraniol) or caffeine (Patent Document 5) Japanese Patent Laid-Open No. 2001-64136, Japanese Patent Laid-Open No. 8-24535). However, with these techniques, even if the sweetness derived from glycyrrhizic acid and its salts is improved, the uncomfortable feeling associated with the sweetness felt in the throat after use remains, and this uncomfortable feeling cannot be improved using the above-mentioned terpene alcohol compounds. It was. For this reason, there was a problem that palatability was not enough.

  On the other hand, 3-L-menthoxypropane-1,2-diol, menthyl lactate, and monomenthyl succinate are used as cooling agents (Patent Document 7; JP-T 9-510627, Patent Document 8). Japanese Patent Publication No. 61-48813). In addition, a plurality of oral compositions using glycyrrhizic acid and salts thereof in combination with 3-L-menthoxypropane-1,2-diol, menthyl lactate, and monomenthyl succinate are disclosed as flavors for imparting a cool feeling. (Patent Document 9; Example 6 of Japanese Patent No. 4591680, Patent Document 10; Example 11 of Japanese Patent Laid-Open No. 2009-256228), using a metal taste derived from a compound that releases metal ions to be used as a masking agent (Patent Document 11; JP-A-2003-137755).

JP 2009-107988 A JP-A-8-40858 JP-A-61-286314 JP 60-130509 A JP 2001-64136 A JP-A-8-24535 JP 9-510627 A Japanese Examined Patent Publication No. 61-48813 Japanese Patent No. 4591680 JP 2009-256228 A JP 2003-137755 A

  However, the conventional technology cannot eliminate the uncomfortable feeling associated with the sweetness felt in the throat derived from glycyrrhizic acid or a salt thereof. Therefore, in the oral composition containing glycyrrhizic acid or a salt thereof, the sweetness felt in the throat. Resolving the uncomfortable feelings associated with was a technical issue.

  The present invention has been made in order to solve the above problems, and an object of the present invention is to provide an oral composition having a good aftertaste that eliminates the uncomfortable feeling associated with sweetness perceived in the throat derived from glycyrrhizic acid or a salt thereof. To do.

  As a result of intensive studies to achieve the above object, the present inventors have found that (A) glycyrrhizic acid or a salt thereof, (B) 3-L-menthoxypropane-1,2-diol, menthyl lactate, mono Combined with one or more components selected from menthyl succinate at a specific ratio, and (C) a nonionic surfactant is blended to give a sweet taste to the throat derived from glycyrrhizic acid or its salt after use It has been found that an oral composition having a good aftertaste without a sense of incongruity can be obtained, and the present invention has been made.

  That is, when glycyrrhizic acid or a salt thereof is blended in an oral composition, particularly a liquid oral composition, after use and vomiting in the oral cavity, the sweetness and throat peculiar to a high-intensity sweetener derived from glycyrrhizic acid or a salt thereof is used. The above-mentioned uncomfortable feeling associated with the sweetness felt in the throat remains, and in particular, the above-mentioned unpleasant feeling associated with the sweetness felt in the throat could not be improved even when a fragrance such as menthol was added to give a refreshing feeling, but surprisingly the component (A) When component (B) is used together in an appropriate ratio and component (C) is blended, the above-mentioned unpleasant sensation associated with sweetness felt in the throat derived from component (A) is suppressed, and aftertaste is improved without remaining after use. , Can give a preparation with good palatability. In addition, although the component (B) is a menthol derivative and is known as a fragrance component of an oral composition, the present inventors cannot make such a component (B) with other fragrance components such as menthol, It has been newly found out that it has exceptional effects such as an uncomfortable feeling and an improved aftertaste.

Therefore, the present invention
(A) 0.05 to 0.2% by mass of glycyrrhizic acid or a salt thereof,
(B) 0.05 to 0.5% by mass of 3-L-menthoxypropane-1,2-diol,
(C) one or more nonionic surfactants selected from polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, decaglycerin fatty acid ester, sucrose fatty acid ester, and polyoxyethylene polyoxypropylene block copolymer 3 to 1% by mass
And (B) / (A) is 0.5 to 3 as a mass ratio, and provides a mouthwash composition in which a compounding component is solubilized .

  ADVANTAGE OF THE INVENTION According to this invention, the discomfort accompanying the sweet taste felt in the throat derived from glycyrrhizic acid or its salt is eliminated, and the composition for oral cavity with a favorable aftertaste can be provided.

  The composition for oral cavity of the present invention comprises one or more components selected from (A) glycyrrhizic acid or a salt thereof, (B) 3-L-menthoxypropane-1,2-diol, menthyl lactate and monomenthyl succinate. And (C) a nonionic surfactant.

Examples of the component (A) glycyrrhizic acid or a salt thereof include glycyrrhizic acid, dipotassium glycyrrhizinate, trisodium glycyrrhizinate, monoammonium glycyrrhizinate, and the like. One of these may be used alone or in combination of two or more. it can. Among them, dipotassium glycyrrhizinate is more preferable from the viewpoint of solubility in water and taste.
A commercially available product can be used as glycyrrhizic acid or a salt thereof. For example, products such as Maruzen Pharmaceutical Co., Ltd.'s standard glycyrrhizinate glycyrrhizinate (standard product for quasi-drugs), glycyrrhizinate monoammonium glycyrrhizinate, glycinone manufactured by Tokiwa Phytochemicals Co., Ltd. Examples are those that are commercialized by name.

  The compounding amount of the component (A) is usually 0.25% or less (mass%, the same applies hereinafter) of the whole composition, particularly preferably 0.001 to 0.25%, more preferably 0.05 to 0.2. %. If it exceeds 0.25%, the effect of improving the uncomfortable feeling associated with the sweetness felt in the throat derived from glycyrrhizic acid or its salt may not be obtained, and the aftertaste may be deteriorated. If it is less than 0.001%, a blending effect such as an anti-inflammatory effect may not be obtained.

Component (B) is a usability improving component that improves the taste derived from component (A). Component (B) is an ester derivative or ether derivative of menthol, and is a component selected from 3-L-menthoxypropane-1,2-diol, menthyl lactate, and monomenthyl succinate. These may be used alone or in combination of two or more. Among these, 3-L-menthoxypropane-1,2-diol is more preferable because of its solubility in water and good aftertaste. Moreover, when using 2 or more types together, the combined use of 3-L-menthoxypropane-1,2-diol and menthyl lactate and / or monomenthyl succinate is preferable from the standpoint of effect expression.
As the component (B), for example, as 3-L-menthoxypropane-1,2-diol, a cooling agent 10 manufactured by Takasago International Inc., as menthyl lactate, FRESCOLAT ML manufactured by Simrise, as monomenthyl succinate , And those commercialized under the trade name such as Fischer made by Ve Man Fis Fragrance Co., Ltd. can be mentioned, and commercially available products can be used.

  The blending amount of component (B) is preferably 0.01 to 1%, more preferably 0.05 to 0.5% of the entire composition. If it is less than 0.01%, the unpleasant sensation associated with the sweetness felt in the throat derived from the component (A) may not be improved, and the aftertaste may be deteriorated. If it exceeds 1%, the aftertaste may be impaired due to irritation or off-flavor due to the component (B).

  In the present invention, it is important for the expression of the effect that the components (A) and (B) are used in an appropriate ratio. In this case, (B) / (A) is 0.05 to 5 in terms of mass ratio, particularly preferably 0.5 to 3, and more preferably 1.10 to 3. When (B) / (A) is less than 0.05, the uncomfortable feeling associated with the sweetness felt in the throat derived from the component (A) cannot be suppressed, the aftertaste is deteriorated, and the feeling of use cannot be improved. When it exceeds 5, the irritation | stimulation derived from a component (B) is strong and a aftertaste is impaired.

Examples of the nonionic surfactant of component (C) include sugar alcohol fatty acid esters, polyhydric alcohol fatty acid esters, ether type or ester type activators, fatty acid alkanolamides, polyoxyethylene polyoxypropylene block polymers, and the like. Is mentioned. Specifically, sucrose fatty acid ester, maltose fatty acid ester, maltitol fatty acid ester, lactol fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, decaglycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol pentaerythritol fatty acid ester, Polyoxyethylene sorbitan fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxy Ethylene castor oil / hardened castor oil, polyoxyethylene lanolin / lanolin Lucol beeswax derivative, polyoxyethylene alkylamine / fatty acid amide, polyoxyethylene alkylphenyl formaldehyde condensate, single chain length polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene block copolymer (Pluronic), polyoxyethylene phytosterol Phytostanol etc. are mentioned, These 1 type can be mix | blended individually or in combination of 2 or more types.
Of these, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, decaglycerin fatty acid ester, sucrose fatty acid ester, and polyoxyethylene polyoxypropylene block copolymer are particularly preferred from the viewpoint of dispersibility of component (B). In particular, polyoxyethylene hydrogenated castor oil is more preferable from the viewpoint of aftertaste.

  The blending amount of the nonionic surfactant of the component (C) is not particularly limited as long as the component (B) can be solubilized, but is preferably 0.2 to 2%, more preferably 0.3 to 1% of the entire composition. It is. If it is less than 0.2%, the component (B) may not be sufficiently solubilized, and the unpleasant sensation and aftertaste associated with the sweetness felt in the throat derived from the component (A) may not be improved. If it exceeds 2%, the off-taste derived from the nonionic surfactant may be strong and the aftertaste may be impaired.

  Moreover, the concentration ratio of the components (B) and (C) is not particularly limited, but (C) / (B) is preferably 2 to 100, more preferably 3 to 10 in terms of mass ratio. If it is less than 2, the usability improvement effect is not exhibited, and there is a case where the uncomfortable feeling and the aftertaste associated with the sweetness felt in the throat derived from the component (A) may not be improved. When it exceeds 100, the off-taste derived from a nonionic surfactant may be strong and aftertaste may be impaired.

  The composition of the present invention is particularly suitably prepared as a liquid oral composition in which the compounding components are solubilized. The composition of the present invention is also effective in a paste-form preparation such as a dentifrice. However, compared with such a preparation, a liquid preparation such as a mouthwash or a liquid dentifrice has a particularly strong taste. Although expressed, according to the present invention, such a liquid preparation can improve the unpleasant taste and aftertaste. Specifically, it is prepared and applied as a mouthwash of the type that is used as it is, a freshener in the mouth, a mouthwash that is diluted at the time of use in a concentrated type, and a liquid dentifrice that is used by brushing with a toothbrush. And is particularly suitable as a mouthwash.

  In addition to the above-mentioned components, other known components can be blended in the composition of the present invention as necessary within a range not impeding the effects of the present invention. Specifically, the liquid oral composition contains a wetting agent, a surfactant, a solvent, and if necessary, a sweetener, a coloring agent, a fragrance, a pH adjuster, an active ingredient, and the like. In addition, it is preferable that solid components which do not solubilize, such as an abrasive | polishing agent, are not normally mix | blended with a liquid oral composition, and an abrasive | polishing agent is not included.

  Examples of the wetting agent include sugar alcohols such as sorbitol, malt, and lactit, and examples of the polyhydric alcohol include glycerin, propylene glycol, ethylene glycol, and polyethylene glycol. The blending amount of these wetting agents is preferably 2 to 20% of the total composition.

As the surfactant, known anionic surfactants, cationic surfactants, amphoteric surfactants and the like can be blended.
Anionic surfactants include sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-acyl sarcosine such as sodium N-lauroyl sarcosine, sodium N-myristoyl sarcosine, sodium dodecylbenzenesulfonate, hydrogenated coconut fatty acid N-acyl glutamate such as sodium monoglyceride monosulfate, sodium lauryl sulfoacetate, sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acylalanine, sodium α-olefin sulfonate Is mentioned.
Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts. Amphoteric surfactants include betaine acetate type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine and fatty acid amidopropyldimethylaminoacetic acid betaine, and imidazoline type such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salt. Examples include amphoteric surfactants.
The amount of these surfactants is usually 0.01 to 2% of the total composition.

As a sweetening agent, xylitol, maltitol, saccharin, saccharin sodium, stevioside, aspartame and the like can be blended.
As a colorant, a highly safe water-soluble pigment such as Blue No. 1, Green No. 3, Yellow No. 4, Red No. 105, and the like can be added.

  Examples of fragrances other than component (B) include eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, basil oil, cardamom oil, coriander oil, peppermint oil, spearmint oil, peppermint oil, orange Oil, lemon oil, mandarin oil, lime oil, grapefruit oil, coconut oil, sweetie oil, lavender oil, rosemary oil, laurel oil, camomile oil, caraway oil, marjoram oil, celery oil, bay oil, origanum oil, pine Needle oil, neroli oil, lemongrass oil, rose oil, jasmine oil, patchouli oil, Iris concrete, rose absolute, orange flower absolute, vanilla absolute, mango absolute, patchoulia absolute, ginger oleoresin, pepper oleo Natural fragrances such as gin, capsicum oleoresin, pepper extract, etc., and fragrances processed by these natural fragrances (front reservoir cut, rear reservoir cut, fractionated liquid extraction, essence, powdered fragrance, etc.) , And limonene, pinene, butanol, isoamyl alcohol, n-hexenol, cis-3-hexenol, cis-6-nonenole, linalool, α-terpineol, menthol, benzyl alcohol, phenylethyl alcohol, anethole, thymol, methylchavicol Eugenol, carvone, menthone, pregon, 1,8-cineole, yonon, caron, n-hexanal, trans-2-hexenal, citral, cinnamaldehyde, benzaldehyde, ethyl acetate, ethyl butyrate, isoamyl acetate, Hexyl acetate, ethyl-2-methylbutyrate, allyl hexanoate, allyl cyclohexane propionate, linalyl acetate, menthyl acetate, carbyl acetate, phenoxyethyl isobutyrate, methyl jasmonate, methyl salicylate, ethyl salicylate, methyl Cinnamate, methyl anthranilate, phenylethyl glycidate, ethyl lactate, vanillin, maltol, gamma and delta lactones having 4 to 12 carbon atoms, ambretlide, dimethyl sulfide, trimethylpyrazine, ethyl-β-methylthiopropionate, Furaneol, ethylcyclopentenolone, cycloten, 2-methylbutyric acid, propionic acid, p-methoxycinnamic aldehyde, menthuri Single flavors such as phosphorus acetal, spiranthol, linalool oxide, vanillyl butyl ether, isopulegol, strawberry flavor, apple flavor, melon flavor, banana flavor, peach flavor, raspberry flavor, pineapple flavor, grape flavor, tropical fruit flavor, mango flavor , Flavors such as ume flavor, orange flavor, lemon flavor, grapefruit flavor, tea flavor, butter flavor, milk flavor, etc., and perfume solvents such as ethyl alcohol, propylene glycol, triacetin, glycerin fatty acid ester, etc. The known perfume materials used can be used in combination. Although the compounding quantity of these fragrance | flavor raw materials is not specifically limited, It can add in the range which does not prevent the effect of this invention. The addition amount is usually 0.000001 to 3% in the composition.

  As a pH adjuster, a well-known thing can be mix | blended as needed. Specific examples include citric acid, malic acid, lactic acid, tartaric acid, acetic acid, phosphoric acid, pyrophosphoric acid, polyphosphoric acid, glycerophosphoric acid, various salts thereof, sodium hydroxide, potassium hydroxide, and the like.

  Active ingredients include antibacterial substances such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, isopropylmethylphenol, triclosan, hinokitiol, enzymes such as glucanase (dextranase, mutanase, etc.), protease, lysozyme chloride, fluoride Fluorides such as sodium, stannous fluoride, sodium monofluorophosphate, aluminum chlorohydroxy allantoin, allantoin, glycyrrhizinate, tranexamic acid, epsilon aminocaproic acid, azulene sulfonate, and other anti-inflammatory agents, ascorbic acid, acetic acid Various vitamins such as tocopherol and pyridoxine, dihydrocholesterol, hydrocholesterol, chlorophyll, copper chlorophyllin sodium, thyme, urgonum, duckweed extract, kami Plant extracts such as les, clove, rosemary, safflower, hamamelis, inorganic salts such as sodium chloride, potassium nitrate, aluminum lactate, zinc chloride, zinc citrate, strontium chloride, water-soluble inorganic phosphate compounds such as sodium polyphosphate, Examples thereof include copper gluconate, caropeptide, polyvinyl pyrrolidone, calculus inhibitor, anti-plaque agent and the like. In addition, the addition amount of these active ingredients can be made into effective amount in the range which does not prevent the effect of this invention.

  As the solvent, water is usually used, and the water content is preferably 60% or more of the total composition. Moreover, you may mix | blend lower monohydric alcohols, such as ethanol, in the range which does not inhibit the effect of this invention.

EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.
The following raw materials were used for the preparation of the oral composition of each example.
Glycyrrhizic acid (manufactured by Tokiwa Plant Chemical Research Co., Ltd.), dipotassium glycyrrhizinate (manufactured by Maruzen Pharmaceutical), monoammonium glycyrrhizinate (manufactured by Maruzen Pharmaceutical), 3-L-menthoxypropane-1,2-diol (Ment Xipropanediol, manufactured by Takasago Fragrance Co., Ltd., menthyl lactate (manufactured by Simrise), monomenthyl succinate (manufactured by We Mann Fis Fragrance Co., Ltd.), polyoxyethylene (60) hydrogenated castor oil (manufactured by Nikko Chemicals), poly Oxyethylene (40) hydrogenated castor oil (Nikko Chemicals), polyoxyethylene (100) hydrogenated castor oil (Nihon Emulsion), polyoxyethylene (40) cetyl ether (Nikko Chemicals), decaglyceryl monolaurate (Manufactured by Nikko Chemicals), Pluronic F127 (ADEKA) ), Sucrose lauric acid ester (L-1695, manufactured by Mitsubishi-Kagaku Foods Corporation), manufactured by citric acid monohydrate (Fuso Chemical Co.), trisodium citrate dihydrate (manufactured by Fuso Chemical Co.)
In the table, POE represents polyoxyethylene, PEG represents polyethylene glycol, and menthoxypropanediol represents 3-L-menthoxypropane-1,2-diol.
According to the composition in the table, the oral composition is prepared by dissolving a water-soluble raw material (excluding nonionic surfactant and solvent) in purified water, and then adding an oil-soluble raw material to ethanol and / or polyhydric alcohol. A solution in which the nonionic surfactant was dissolved was added with stirring to achieve uniform dissolution. A three-one motor (BL1200, manufactured by HEIDON) was used for manufacturing.

[Examples and comparative examples]
The composition for oral cavity (mouth wash) of the composition shown in Tables 1-3 was prepared by the said method, and the following method evaluated. The results are shown in Tables 1-3.

Evaluation method:
The mouthfeel containing 10 mL of the mouthwash (sample) shown in the table was evaluated in the following four stages for the feeling of use after rinsing and discharging for 30 seconds, and the average score of 10 panelists was evaluated according to the following criteria: ◎, ○, △ , X in the table.
<1> Effect of reducing discomfort associated with sweetness perceived in throat derived from glycyrrhizic acid or a salt thereof Score standard 4: No discomfort associated with sweetness perceived in throat 3: No discomfort associated with sweetness perceived in throat 2: Slightly felt uncomfortable with the sweetness felt in the throat 1: Slightly felt the uncomfortable feeling associated with the sweetness felt in the throat Evaluation criteria for the uncomfortable feeling associated with the sweetness felt in the throat ◎: Average score of 3.5 or higher 0 or less ○: Average point 3.0 or more and less than 3.5 point Δ: Average point 2.0 or more and less than 3.0 point ×: Average point 1.0 or more and less than 2.0

<2> Good aftertaste after use Rating criteria 4: Very good aftertaste 3: Somewhat good aftertaste 2: Somewhat bad aftertaste 1: Very bad aftertaste Evaluation criteria for good aftertaste ◎: Average score 3 0.5 to 4.0 points ○: Average point 3.0 to less than 3.5 points △: Average point 2.0 to less than 3.0 points ×: Average point 1.0 to 2.0 points Less than

Claims (4)

(A) 0.05 to 0.2% by mass of glycyrrhizic acid or a salt thereof,
(B) 0.05 to 0.5% by mass of 3-L-menthoxypropane-1,2-diol,
(C) one or more nonionic surfactants selected from polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, decaglycerin fatty acid ester, sucrose fatty acid ester, and polyoxyethylene polyoxypropylene block copolymer 3 to 1% by mass
A mouthwash composition in which a blending component is solubilized , wherein (B) / (A) is 0.5 to 3 as a mass ratio.   The mouthwash according to claim 1, wherein the component (C) is one or more nonionic surfactants selected from polyoxyethylene hydrogenated castor oils having an average added mole number of ethylene oxide of 40, 60 and 100. Composition.   (C) / (B) is 2-100 as mass ratio, The mouthwash composition of Claim 1 or 2.   The mouthwash composition according to claim 1, 2 or 3, wherein an abrasive which is a solid component is not blended in the composition.