JP2022010431A - Oral composition - Google Patents

Abstract

To provide an oral composition having improved bitterness derived from berberine, reduced bitterness even after use, refresh feeling of use, good aftertaste, and effectiveness for prevention or suppression of periodontal diseases such as gingival inflammation.SOLUTION: The oral composition comprises (A) Berberine and (B) one or more selected from menthone glycerin acetal and N-(4-methoxyphenyl)-5-methyl-p-menthane carboxamide. The oral composition further comprises (C) a nonionic surfactant.SELECTED DRAWING: None

Description

INDUSTRIAL APPLICABILITY The present invention improves the bitterness derived from berberine, reduces the bitterness even after use, gives a refreshing feeling of use, has a good aftertaste, and is suitable for prevention or suppression of periodontal diseases such as gingival inflammation. Regarding the composition for use.

Conventionally, various active ingredients have been blended in oral compositions for the purpose of preventing or treating defects in the oral cavity. Among them, berberine exerts an anti-inflammatory effect in plant extracts such as gingival extract containing berberine. However, it is a useful ingredient for preventing periodontal diseases such as gingival inflammation. However, since plant extracts containing berberine, especially Phellodendron amur extract, have a unique herbal-like bitterness derived from berberine, an oral composition containing them is not preferable in terms of palatability, and the bitterness affects the aftertaste. , There was a tendency that a satisfactory usability could not be obtained.
Patent Document 1 (Japanese Unexamined Patent Publication No. 62-155209) proposes that the bitterness of berberine is improved by adding a nonionic activator such as a fatty acid alkanolamide to an oral composition containing berberine. There was still room for improvement in the aftertaste without paying attention to the aftertaste.
Patent Document 2 (Japanese Patent No. 6284136) proposes a bitterness masking technique for foods and drinks containing a bitterness component such as Phellodendron amur, using a bitterness inhibitor containing isobutyl angelate as an active ingredient. The bitterness masking effect in the composition was not sufficient.
Regarding the Oubaku extract, patented documents include β-glycyrrhetinic acid blended in oral compositions such as dentifrice compositions, and techniques used for masking the taste of cetylpyridinium chloride and benzethonium chloride, which are quaternary ammonium salt bactericides. Although it has been proposed in 3 and 4 (Japanese Patent Laid-Open No. 2012-148998, Japanese Patent Application Laid-Open No. 2015-86164), the effect is limited, and the bitterness masking of the Oubaku extract itself is not mentioned.

By the way, in the oral composition, it is important to give a refreshing feeling of use as an aftertaste, which leads to a real feeling of effect and is important in terms of commercial value. From consumer surveys and the like, it has been found that maintaining a refreshing feeling even after use fosters a feeling of effectiveness in preventing periodontal disease, and further sustainability of the refreshing feeling is required. A refreshing feeling can be obtained to some extent by adding menthol, mint oil, etc., which are general oral fragrances, but increasing the amount may cause irritation, etc., and also from the viewpoint of bitterness and less irritation. A cooling sensation agent (cooling agent) may be added, but depending on the type of cooling sensation agent, the bitterness due to other ingredients may be enhanced. In particular, in the liquid oral composition, the amount used at one time is 10 to 20 mL, which is 10 to 20 times the amount of toothpaste, and since it is relatively large, the bitterness is felt more strongly and the palatability tends to be impaired. Therefore, it was difficult to secure a refreshing aftertaste.

Japanese Unexamined Patent Publication No. 62-155209 Japanese Patent No. 6284136 Japanese Unexamined Patent Publication No. 2012-148998 Japanese Unexamined Patent Publication No. 2015-86164

The present invention has been made in view of the above circumstances, and provides an oral composition having a good aftertaste, which improves the bitterness derived from berberine, reduces the bitterness even after use, and gives a refreshing feeling of use. With the goal.

As a result of diligent studies to achieve the above object, the present inventor has improved the bitterness derived from berberine when a specific cooling sensation agent is added to the oral composition containing berberine, and the bitterness is improved immediately after use and over time. It was found that the feeling of discomfort associated therewith was moderately reduced, the feeling of use was remarkably refreshed, and the feeling of use was excellent with a good aftertaste. That is, in the present invention, velverin is formed by blending (A) velverin with one or more selected from (B) menthone glycerin acetal and N- (4-methoxyphenyl) -5-methyl-p-menthancarboxamide. An oral composition having a good aftertaste, which improves the derived bitterness, suppresses and reduces the bitterness even after use, and gives a refreshing feeling of use, can prevent or suppress periodontal diseases such as gingival inflammation. It was found that it is effective for use, and the present invention was made.

In the present invention, the bitterness derived from the component (A) is masked and appropriately suppressed by the component (B), and even if the component (A) is blended as a plant extract such as Phellodendron amur, its herbal-like unique bitterness is exhibited. It is suppressed and can specifically give the above-mentioned excellent action and effect. Further, by blending the components (A) and (B) in combination, a liquid oral composition such as a mouthwash, which is used in a relatively large amount at one time and whose palatability is relatively easily impaired by bitterness or the like. Even so, the bitterness is suppressed in the oral cavity immediately after use and even after a lapse of time, the bitterness is moderately reduced, and a refreshing feeling of use can be maintained, and the aftertaste can be further improved.
As shown in the comparative example described later, when the component (B) is not blended, N-ethyl-p-menthane-3-carboxamide or 3-mentoxypropane-1,2, which are also known as cooling sensitizers, are used. -Even if diol is blended and menthol or peppermint oil is added as a fragrance, the bitterness derived from the component (A) is not reduced, and the bitterness after use (immediately after use and after 10 minutes) is inferior. It was a thing. On the other hand, the oral composition (mouthwash) containing the components (A) and (B) of the present invention shown in Examples has no bitterness after use (immediately after use and after 10 minutes have passed). Was excellent, the refreshing feeling after use (immediately after use and after 10 minutes) was also excellent, and the aftertaste was good.
Patent Documents 1 and 2 are for improving the bitterness of berberine by using a nonionic activator or isobutyl angelate, whereas the present invention is based on the component (B) in the oral composition, which is the component (A). ) Is an improvement in bitterness, and a refreshing feeling of use can be maintained even after use, and an excellent feeling of use with a good aftertaste can be given.

Therefore, the present invention provides the following oral compositions.
[1]
(A) Berberine and
(B) An oral composition comprising one or more selected from menthone glycerin acetal and N- (4-methoxyphenyl) -5-methyl-p-menthancarboxamide.
[2]
(A) The oral composition according to [1], wherein berberine is derived from a plant extract selected from Phellodendron amur and Coptis chinensis and contains 0.005 to 0.5% by mass of the plant extract (A1).
[3]
The oral composition according to [2], wherein (B) / (A1) indicating the quantitative ratio of the component (A1) to the component (B) is 0.05 to 80 as a mass ratio.
[4]
The oral composition according to any one of [1] to [3], which contains 0.0003 to 0.03% by mass of the component (A) and 0.01 to 0.4% by mass of the component (B).
[5]
The oral composition according to any one of [1] to [4], which further contains (C) a nonionic surfactant in an amount of 0.3 to 1% by mass.
[6]
The oral composition according to [5], wherein (C) / (B) indicating the quantitative ratio of the component (C) to the component (B) is 1 to 100 as a mass ratio.
[7]
The oral composition according to any one of [1] to [6], which is a liquid.

According to the present invention, it is possible to provide an oral composition having a good aftertaste, which improves the bitterness derived from berberine, reduces the bitterness even after use, and gives a refreshing feeling of use. The oral composition of the present invention has an anti-inflammatory effect due to berberine, has almost no bitterness even after use, maintains a high refreshing feeling and has an excellent aftertaste, and is used for preventing or suppressing periodontal diseases such as gingival inflammation. Is suitable as.

Hereinafter, the present invention will be described in more detail. The oral composition of the present invention contains (A) berberine and (B) one or more selected from (B) menthone glycerin acetal and N- (4-methoxyphenyl) -5-methyl-p-menthan carboxamide. More preferably, it contains (C) a nonionic surfactant.

(A) Berberine can be blended as a plant extract containing berberine, and a plant extract selected from Phellodendron amur and Coptis chinensis (plant extract (A1)) can be blended. Berberine has an anti-inflammatory effect, is an active ingredient for preventing or suppressing periodontal diseases such as gingival inflammation, and has a bitter taste.
As the plant extract (A1), Phellodendron amur extract and Coptis chinensis extract can be used, and Phellodendron amur extract is particularly preferable.
As the Coptis chinensis extract and Coptis chinensis extract, an extract obtained by extracting each raw material plant with a hydrophilic organic solvent (water, ethanol, etc.) can be used, and a powder obtained by drying the extract can also be used. .. Commercially available products can also be used for these.
Oubaku extract is obtained by extracting the bark of Phellodendron amurense (scientific name: Phellodendron amurense Ruprecht) or other related plants (Rutaceae) excluding the peripheral bark with water, a hydrophilic organic solvent (water, ethanol, etc.) or a mixture thereof. However, an extract containing water or hydrous ethanol is particularly suitable, and a dry powder thereof may be used. As the above-mentioned Phellodendron amur extract, a commercially available product can be used, and for example, a powder-type Phellodendron amurus extract manufactured by Koshiro Pharmaceutical Co., Ltd. can be used.
As the Coptis chinensis extract, an extract or a dry powder thereof obtained by extracting the roots and stems of Coptis chinensis, which is a plant belonging to the genus Coptis genus of the family Ranunculales, in the same manner as described above can be used.

The blending amount of the component (A) is preferably 0.0003 to 0.03% (mass%, the same applies hereinafter) of the entire composition in terms of solid content, and more preferably 0.0012 to 0.012%. When the blending amount is 0.0003% or more, a sufficient anti-inflammatory effect is exhibited, and when it is 0.03% or less, the bitterness is sufficiently suppressed and a refreshing feeling can be imparted.
When the component (A1), particularly Phellodendron amur extract, is blended as the component (A), the blending amount thereof is preferably 0.005 to 0.5% of the total composition from the viewpoint of suppressing bitterness and imparting a refreshing feeling. , More preferably 0.02 to 0.2%.

The component (B) is menthone glycerin acetal, N- (4-methoxyphenyl) -5-methyl-p-menthan carboxamide. These are known as cooling sensation agents, but in the present invention, they act as a bitterness inhibitor of the component (A), continuously suppress and reduce the bitterness derived from the component (A), and at the same time, use them neatly. It also has the effect of sustaining a feeling and improves the aftertaste.
As the component (B), menthone glycerin acetal and / or N- (4-methoxyphenyl) -5-methyl-p-menthancarboxamide can be used, and among them, from the viewpoint of solubility, suppression of bitterness and imparting a refreshing feeling. , Menthone glycerin acetal is more preferred.
The component (B) includes menthone glycerin acetal (Frescolat MGA, manufactured by Symrise Co., Ltd.), N- (4-methoxyphenyl) -5-methyl-p-menthancarboxamide (WS-12, manufactured by Symrise Co., Ltd.), and the like. Commercially available products can be used.

The blending amount of the component (B) is preferably 0.01 to 0.4%, more preferably 0.05 to 0.2% of the entire composition. When the blending amount is 0.01% or more, the bitterness can be sufficiently suppressed and a refreshing feeling can be imparted. When it is 0.4% or less, irritation and sarcasm derived from the component (B) are suppressed, and the effect of suppressing bitterness is sufficiently maintained.

The mass ratio of the component (B) / component (A) indicating the amount ratio of the component (A) (solid content equivalent amount) to the component (B) is preferably 0.8 to 1,333, more preferably 4 to 4. 400, more preferably 4 to 167. Within the above range, the bitterness is further suppressed and a refreshing feeling can be continuously obtained.
When the component (A1) is blended as the component (A), the mass ratio of (B) / (A1) indicating the quantitative ratio of the component (A1) to the component (B) is preferably 0.05 to 80, more preferably. It is preferably 0.25 to 24, more preferably 0.25 to 10.

In the present invention, it is preferable to further add (C) a nonionic surfactant.
(C) The nonionic surfactant exerts an action of solubilizing the component (B) and more effectively expressing its action and effect.
Examples of the nonionic surfactant include polyalcohol fatty acid esters such as sugar alcohol fatty acid esters, sugar fatty acid esters, and polyglycerin fatty acid esters, polyoxyethylene fatty acid esters, polyoxyethylene alkyl ethers, fatty acid alkanolamides, and polyoxyethylene. Examples thereof include polyoxypropylene block polymers. Among them, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, decaglycerin fatty acid ester, sucrose fatty acid ester, and polyoxyethylene polyoxypropylene block copolymer are preferable from the viewpoint of suppressing bitterness and imparting a refreshing feeling, and are particularly refreshing. From the viewpoint of imparting a feeling (refreshing feeling of aftertaste), polyoxyethylene hydrogenated castor oil is preferable, and polyethylene oxide having an average addition molar number of 5 to 100 can be used. Polyoxyethylene hydrogenated castor oil is a nonionic surfactant having a relatively bitter taste, but in the present invention, even if polyoxyethylene hydrogenated castor oil is blended as the component (C), the bitterness is sufficiently suppressed. It is excellent in this effect.

The blending amount of the nonionic surfactant of the component (C) is not particularly limited as long as the component (B) can be solubilized, but is preferably 0.3 to 1% of the entire composition, and more preferably 0.3 to 0. It is 8.8%, more preferably 0.5 to 0.8%. Within the above range, the component (B) is sufficiently solubilized, and the effect of suppressing bitterness and the effect of imparting a refreshing feeling are enhanced. When the blending amount is 1% or less, the bitterness of the component (C) itself is suppressed, and the effect of suppressing the bitterness is maintained.

The mass ratio of (C) / (B) indicating the quantitative ratio of the component (C) to the component (B) is preferably 1 to 100, more preferably 2.5 to 16. Within the above range, the bitterness of the component (B) itself and the sarcasm of the component (C) itself are suppressed, the bitterness is further suppressed, and the refreshing feeling is maintained.

The oral composition of the present invention is particularly prepared in the form of a liquid and is suitable as a liquid oral composition, and can be used in the form of liquid toothpaste, mouthwash, mouthwash, etc. Is preferable. In addition, it can be prepared by adopting a usual method. In this case, an appropriate known component may be blended in addition to the above-mentioned components depending on the purpose of the composition, the dosage form, and the like. The liquid oral composition specifically contains a wetting agent, a surfactant, a solvent, and if necessary, a sweetening agent, a coloring agent, a fragrance, a pH adjuster, an active ingredient, and the like. It is preferable that the liquid oral composition does not usually contain a solid component that is not solubilized, such as an abrasive, and does not contain an abrasive.

Examples of the wetting agent include sugar alcohols such as sorbitol, martit and lacchit, and polyhydric alcohols such as glycerin, propylene glycol, ethylene glycol and polyethylene glycol. The blending amount of these wetting agents is usually 2 to 20% of the total composition.

Any surfactant can be blended with known anionic surfactants, cationic surfactants, amphoteric surfactants and the like.
Anionic surfactants include alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, N-acylsarcosine salts such as N-lauroyl sarcosin sodium and N-myristoyl sarcosin sodium, sodium dodecylbenzene sulfonate, hydrogenated coconut fatty acid monoglyceride. Examples include N-acylglutamate such as sodium monosulfate, sodium lauryl sulfoacetate, and sodium N-palmitoyl glutamate, sodium N-methyl-N-acyltaurine, sodium N-methyl-N-acylalanine, and sodium α-olefin sulfonate. Be done.
Examples of the cationic surfactant include alkylammonium and alkylbenzylammonium salts.
Amphoteric surfactants include betaine acetate-type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine and betaine fatty acid amide propyldimethylaminoacetic acid betaine, and imidazoline-type amphoteric salts such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salt. Examples include surfactants.
The blending amount of these arbitrary surfactants is preferably 0.01 to 2% of the total composition.

Examples of the sweetener include xylitol, maltitol, saccharin, sodium saccharin, stebioside, aspartame and the like.

Examples of the colorant include highly safe water-soluble dyes such as Blue No. 1, Green No. 3, Yellow No. 4, and Red No. 105.

Fragrances include, for example, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, basil oil, cardamon oil, coriander oil, peppermint oil, spearmint oil, peppermint oil, orange oil, lemon oil, mandarin oil. , Lime oil, grapefruit oil, yuzu oil, sweetie oil, lavender oil, rosemary oil, laurel oil, camomill oil, caraway oil, majorum oil, celery oil, bay oil, origanum oil, pine needle oil, neroli oil, lemon Glass oil, rose oil, jasmine oil, patchouli oil, iris concrete, rose absolute, orange flower absolute, vanilla absolute, mango absolute, patchuriabsolute, ginger oleoledin, peppermint olegin, capsicum oleoledin, peppermint extract, etc. Natural fragrances, fragrances processed by processing these natural fragrances (front reservoir cut, rear reservoir cut, distilling, liquid extraction, essence, powder fragrance, etc.), limonene, mint, butanol, isoamyl alcohol, n- Hexenol, cis-3-hexenol, cis-6-nonenor, linalol, α-terpineol, menthol, benzyl alcohol, phenylethyl alcohol, anator, timol, methylchabicol, eugenol, carboxylic, menton, pregon, 1,8-cineol , Jonon, Caron, n-hexanal, trans-2-hexenal, citral, cinnamaldehyde, benzaldehyde, ethyl acetate, ethyl butyrate, isoamyl acetate, hexyl acetate, ethyl-2-methylbutyrate, allyl hexanoate, allyl cyclohexane Propionate, Linalyl Acetate, Mentil Acetate, Calvia Acetate, Phenoxyethyl Isobutyrate, Methyl Jasmonate, Methyl Salicylate, Ethyl Salicylate, Methyl Synnate, Methyl Anthranilate, Phenylethyl Glycydate, Ethyl Lactate, Vanillin, Martol, gamma or deltalactone with 4-12 carbon atoms, ambretlide, dimethylsulfide, trimethylpyrazine, ethyl-β-methylthiopropionate, flaneol, ethylcyclopentenolone, cycloten, 2-methylbutyric acid, propio Nickacid, p-methoxycinnamic aldehyde, spirantol, linalol oxide, ba Nirylbutyl ether, isopulegol, menthyl lactate, monomentyl succinate, monomentyl glutarate, menthyl ethylene glycol carbonate, menthyl propylene glycol carbonate, 3-mentoxypropane-1,2-diol, N-ethyl-p-menthane-3 -Carboxamide, ethyl (3- (p-menthan-3-carboxamide) acetate, N- (4-cyanomethylphenyl) -p-menthan carboxamide, 2-isopropyl-5-methyl-N- (2-pyridinylethyl) cyclohexanecarboxamide Single flavor, strawberry flavor, apple flavor, melon flavor, banana flavor, peach flavor, raspberry flavor, pineapple flavor, grape flavor, tropical fruit flavor, mango flavor, ume flavor, orange flavor, lemon flavor, grapefruit flavor, etc. , Butter flavor, milk flavor and the like, and known perfume materials used in oral compositions can be used in combination. Further, a fragrance solvent such as ethyl alcohol, propylene glycol, triacetin, and glycerin fatty acid ester can be added. The blending amount of the fragrance material is not particularly limited and can be added within a range that does not interfere with the effects of the present invention, but is usually 0.000001 to 3% of the total composition.

As the pH adjuster, known ones can be blended as needed. Specific examples thereof include citric acid, malic acid, lactic acid, tartaric acid, acetic acid, phosphoric acid, pyrophosphate, polyphosphoric acid, glycerophosphate and various salts thereof, sodium hydroxide, potassium hydroxide and the like.

The active ingredients are antibacterial substances such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, isopropylmethylphenol, triclosan, hinokithiol, glucanase (dextranase, mutanase, etc.), protease, enzymes such as lysoteam chloride, sodium fluoride. , Fluorine-containing compounds such as stannous fluoride, sodium monofluorophosphate, aluminum chlorhydroxyalantin, allantin, glycyrrhizinic acid, dipotassium glycyrrhizinate, trisodium glycyrrhizinate, monoammonium glycyrrhizinate, tranexamic acid, epsilon aminocaproic acid, azulene. Anti-inflammatory agents such as sulfonates, vitamins such as ascorbic acid, tocopherol acetate, pyridoxin, dihydrocholesterol, hydrocholesterol, chlorophyll, sodium copper chlorophyllin, thyme, ginger, chamomile, chowji, rosemary, benivana, hamamelis, etc. Plant extracts, sodium chloride, potassium nitrate, aluminum lactate, zinc chloride, zinc citrate, strontium chloride and other inorganic salts, water-soluble inorganic phosphate compounds such as sodium polyphosphate, copper gluconate, caropeptide, polyvinylpyrrolidone, dentin inhibitors , Anti-staining agent. The amount of these active ingredients added can be an effective amount as long as the effects of the present invention are not impaired.

Water is usually used as the solvent, and the content of water is preferably 60% or more of the whole composition. Further, a lower monohydric alcohol such as ethanol can be blended within a range that does not interfere with the effects of the present invention.

Hereinafter, the present invention will be specifically described with reference to Examples, Comparative Examples, and Prescription Examples, but the present invention is not limited to the following Examples. In the following examples,% indicates mass% unless otherwise specified.

[Examples, comparative examples]
A liquid oral composition (mouthwash) containing the components shown in Tables 2 to 4 with the basic composition shown in Table 1 was prepared by the following method, and the usability was evaluated by the following method. The results are also shown in the table.

Preparation method:
To prepare the liquid oral composition (mouthwash), dissolve the water-soluble raw materials (excluding nonionic surfactants and solvents) in purified water according to the composition in the table, and then add ethanol and polyhydric alcohol. A solution in which an oil-soluble raw material and a nonionic surfactant were dissolved was added with stirring to uniformly dissolve the solution. A three-one motor (BL1200, manufactured by HEIDON) was used for manufacturing.

Evaluation method of usability 10 subjects contained 10 mL of mouthwash in their mouth, rinsed their mouth for 30 seconds, exhaled, and then had no bitterness after use (no bitterness immediately after use and after 10 minutes). The refreshing feeling after use (the refreshing feeling immediately after use and after 10 minutes) was evaluated according to the following scoring criteria. The average value of 10 subjects was calculated and indicated by ⊚, 〇, Δ, and × according to the following evaluation criteria.

(I) No bitterness after use (immediately after use, after 10 minutes have passed)
Rating criteria 4 points: Almost no bitterness 3 points: Slight bitterness 2 points: Bitterness 1 point: Very bitterness Evaluation criteria Average score of no bitterness after use ◎: 3.5 points or more 4 .0 points or less ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and less than 3.0 points ×: 1.0 points or more and less than 2.0 points

(Ii) Refreshing feeling after use (immediately after use, after 10 minutes have passed)
Rating criteria 4 points: Very refreshing feeling 3 points: Feeling refreshing feeling 2 points: Feeling refreshing feeling 1 point: Feeling refreshing feeling at all Evaluation criteria Average score after use ◎: 3.5 points 4.0 points or less ○: 3.0 points or more and less than 3.5 points △: 2.0 points or more and less than 3.0 points ×: 1.0 points or more and less than 2.0 points

Details of the raw materials used are shown below.
(A) Phellodendron amur extract (A1) (manufactured by Koshiro Pharmaceutical Co., Ltd., powder, berberine content 6%)
(B) Menthone glycerin acetal (Frescolat MGA, manufactured by Symrise Co., Ltd.)
(B) N- (4-Methoxyphenyl) -5-methyl-p-menthancarboxamide (WS-12, manufactured by Symrise Co., Ltd.)
(C) Polyoxyethylene (60) hardened castor oil (manufactured by Nikko Chemicals Co., Ltd.)
N-Ethyl-p-Menthane-3-carboxamide (comparative product) (WS-3, manufactured by Symrise Co., Ltd.)
3-Mentoxypropane-1,2-diol (comparative product) (CA10, manufactured by Takasago International Corporation)
The amount of berberine in the table is the amount converted to solid content of berberine (the same applies hereinafter).

(*) Fragrance composition Anethole 2
Menthol 3
Peppermint oil 20
Mentil Lactate 5
Ethanol 70
100% in total

As is clear from the results in Tables 2 to 4, the mouthwash (Example) containing the components (A) and (B) of the present invention, and further the component (C), has no bitterness after use (examples). Immediately after use and after 10 minutes had passed, and after 10 minutes had passed, the refreshing feeling (immediately after use and after 10 minutes) was excellent. On the other hand, the mouthwash (comparative example) lacking the component (B) was inferior in bitterness after use (immediately after use and after 10 minutes), and the object of the present invention was not achieved.

Next, a prescription example is shown. When the composition of the formulation example was prepared using the same raw materials as above and evaluated, there was no bitterness after use (immediately after use and after 10 minutes) and a refreshing feeling after use (immediately after use and after 10 minutes). ), But both were excellent.

[Prescription Example 1] Mouthwash (A) Phellodendron amur extract (A1) 0.05
(Amount of berberine 0.003)
(B) Menthone Glycerin Acetal 0.12
(C) Polyoxyethylene (100) hardened castor oil 0.6
Xylitol 4
Glycerin 2
Propylene glycol 2
Ethanol 5
Citric acid 0.01
Sodium citrate 0.25
Saccharin sodium 0.005
Sucralose 0.05
Fragrance 0.1
Purified water residue
100% in total
(B) / ((A1)) Mass ratio = 2.4
(C) / (B) Mass ratio = 5

[Prescription Example 2] Oral agent (A) Phellodendron amur extract (A1) 0.05
(Amount of berberine 0.003)
(B) Menthone Glycerin Acetal 0.08
(B) N- (4-Methoxyphenyl) -5-methyl-p-menthancarboxamide
0.04
(C) Polyoxyethylene (60) Hardened castor oil 0.6
Sorbitol 4
Glycerin 2
Propylene glycol 5
Citric acid 0.03
Sodium citrate 0.1
Saccharin sodium 0.01
Fragrance 0.1
Purified water residue
100% in total
(B) / ((A1)) Mass ratio = 2.4
(C) / (B) Mass ratio = 5

Claims (7)

(A) Berberine and
(B) An oral composition comprising one or more selected from menthone glycerin acetal and N- (4-methoxyphenyl) -5-methyl-p-menthancarboxamide. (A) The oral composition according to claim 1, wherein berberine is derived from a plant extract selected from Phellodendron amurensis and Coptis chinensis and contains 0.005 to 0.5% by mass of the plant extract (A1). The oral composition according to claim 2, wherein (B) / (A1) indicating the quantitative ratio of the component (A1) to the component (B) is 0.05 to 80 as a mass ratio. The oral composition according to any one of claims 1 to 3, which contains 0.0003 to 0.03% by mass of the component (A) and 0.01 to 0.4% by mass of the component (B). The oral composition according to any one of claims 1 to 4, further comprising (C) 0.3 to 1% by mass of a nonionic surfactant. The oral composition according to claim 5, wherein (C) / (B) indicating the quantitative ratio of the component (C) to the component (B) is 1 to 100 as a mass ratio. The oral composition according to any one of claims 1 to 6, which is a liquid.