JP2000143468A - Liquid composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition capable of removing the fatty stains in the oral cavity without irritating oral mucosa. SOLUTION: This liquid composition for oral cavity is characteristic in compounding (a) 0.001-0.04 wt.% of one or more kinds of polymeric substance selected from the group consisting of xanthan gum, carrageenan, alginate salts and polyacrylate salts, (b) a polyhydric alcohol, and (c) a nonionic surfactant.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition for a liquid oral cavity which has improved detergency against oral greasy stains derived from foods and the like.

[0002]

2. Description of the Related Art If one does not brush his teeth after eating at a place where he or she is away, greasy dirt derived from foods and the like remains in the oral cavity and is extremely unpleasant. Therefore, conventionally, a mouthwash, a mouth spray, and the like have been used to refresh the mouth after eating without brushing the teeth. However, these ingredients give a refreshing feeling in the oral cavity by flavor components such as menthol, but they do not have sufficient detergency, so when the flavor components disappear, the inside of the mouth becomes unpleasant again.

[0003] Food residues also cause bad breath. There is also known a technique for preventing bad breath by blending a deodorant component such as a plant extract into mouthwash or the like (JP-A-59-13712, JP-A-63-24950, JP-A-Hei-5-24950). No. 339137), it is not possible to remove oily dirt which causes discomfort in the mouth. On the other hand, in a liquid oral composition, a technique for increasing the retention of menthol in the oral cavity is also known (Japanese Patent Application Laid-Open No. 8-333227), but this only extends the time for which the refreshing sensation is maintained. It is not a fundamental solution to discomfort in the oral cavity.

[0004] In this case, if an anionic surfactant is added to the liquid oral composition to provide further detergency, the oral mucosa may be irritated. Therefore, it is desired to improve the detergency by means that does not stimulate the oral mucosa.

[0005] An object of the present invention is to provide a composition for a liquid oral cavity which meets the above-mentioned demands, has an excellent detergency against grease and dirt in the oral cavity and does not irritate the oral mucosa.

[0006]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies to achieve the above object, and surprisingly found that polyhydric alcohols, nonionic surfactants and necessary In a liquid oral composition containing ethanol, one or more polymer substances selected from the group consisting of xanthan gum, carrageenan, alginate, and polyacrylate are added in an amount of 0.1% to the entire composition.
The inventor has found that by adding 001 to 0.04% by weight, the detergency of oil and fat stains is remarkably improved, and the present invention has been accomplished.

Hereinafter, the present invention will be described in more detail.
Liquid oral composition according to the present invention, liquid dentifrice, water dentifrice,
Prepared and applied as mouthwash, mouthwash, etc.
One or more polymer substances selected from the group consisting of xanthan gum, carrageenan, alginate, and polyacrylate in a liquid oral composition containing a polyhydric alcohol, a nonionic surfactant and, if necessary, ethanol. Is contained in an amount of 0.001 to 0.04% by weight based on the whole composition, whereby oil and fat stains in the oral cavity can be removed without irritating the oral mucosa.

The polymer substance used in the present invention is one or more selected from the group consisting of xanthan gum, carrageenan, alginate, and polyacrylate.
The compounding ratio with respect to the whole composition is 0.001 to 0.04% by weight. If the concentration of the polymer substance in the composition is higher than this, the viscosity increases, which makes the composition unsuitable for rinsing. One or more water-soluble polymers selected from xanthan gum, carrageenan, sodium carboxymethyl cellulose and sodium alginate are added to the mouthwash in an amount of 0.1 to 0.8% by weight of the whole mouthwash. By l-
There is known an example in which menthol is improved in the retention in the oral cavity and a thick and unique feeling of use is imparted (Japanese Patent Application Laid-Open No. Hei 8-
333227), which is different from the present invention in the purpose and the blending amount of the polymer substance.

The polyhydric alcohol used in the present invention is a commonly used polyhydric alcohol such as glycerin, sorbitol, xylitol, propylene glycol, polyethylene glycol, maltitol, erythritol,
Idit, talit, dullcit, alit, arabit, adnit, and the like can be used. In particular, one or more of glycerin, sorbitol, xylitol, propylene glycol, polyethylene glycol, maltitol, and erythritol can be suitably used. When polyethylene glycol is used, it is desirable to use one having a molecular weight that is colorless and transparent at normal temperature. The polyhydric alcohol concentration in the composition is 0.05 to 30% by weight,
In particular, the content is desirably 0.1 to 20% by weight.

The nonionic surfactant used in the present invention is a nonionic surfactant widely used, that is, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene copolymer, Sugar fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbite fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene glycol fatty acid ester, polyoxyethylene alkyl ether Phosphoric acid and its salts, polyoxyethylene alkyl ether sulfates, polyoxyethylene phytosterols and phytostanols, polyoxyethylene alkyl esters Nyl ether phosphoric acid and its salts, polyoxyethylene lanolin and lanolin alcohol, polyoxyethylene alkylamine and fatty acid amide, polyoxyethylene alkylphenylformaldehyde condensate, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkylphenyl Ether, polyoxyethylene alkylphenyl ether and fatty acid ethanolamide, and the like. Particularly, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene Preferred are ethylene sorbite fatty acid ester, sorbitan fatty acid ester, polyglycerin fatty acid ester, and fatty acid ethanolamide. Used to. The concentration of the nonionic surfactant in the composition is from 0.1 to
It is desirable that the content be 10% by weight, particularly 0.2 to 5% by weight.

Further, ethanol is contained in an amount of 0 to 50 in the total composition.
%, Preferably in the range of 0 to 30% by weight.
The ethanol used here is absolute ethanol,
Ethanol containing water or the like, denatured ethanol denatured with a predetermined flavor, dye, or the like may be used.

As other components of the present invention, appropriate components usually used can be blended according to the kind of the liquid oral composition and the like.

For example, as a buffer, one or more of citric acid and its salts, malic acid and its salts, phosphoric acid and its salts, and the like can be blended (the blending amount is usually 0.01 to 1).
weight%).

As preservatives and bactericides, benzoic acid and its salts, salicylic acid and its salts, parabens, cetylpyridinium chloride, decalinium chloride, benzethonium chloride, benzalkonium chloride, chlorhexidine hydrochloride,
One or more of chlorhexidine gluconate, isopropylmethylphenol, triclosan, hinokitiol, phenol and the like may be blended (the blending amount is usually 0.0
01-0.5% by weight).

The fragrance is peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil,
Orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime oil, lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil,
Natural flavors such as pine needle oil and menthol, carvone, anethole, cineol, methyl salicylate, cinamic aldehyde, eugenol, thymol, linalool, linalool acetate, limonene, menthone, menthyl acetate, pinene, octylaldehyde, citral, pulegone, cal Beer acetate, an individual fragrance such as anisaldehyde, further, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, hexanal, ethyl alcohol, propyl alcohol, Strawberry flavor, apple flavor, and bamboo flavor of mixed flavors including single flavor and / or natural flavor in addition to butanol, isoamyl alcohol, etc. Naflavor, pineapple flavor, grape flavor, mango flavor, tropical fruit flavor, butter flavor, milk flavor, fruit mix flavor, and the like, known perfumes used for oral compositions can be used, and are limited to the perfumes of Examples. Not done. Also, the amount is not particularly limited, but as in many known examples, it is preferable that the perfume material is used in the composition at 0.00001 to 1% by weight.

The liquid oral composition of the present invention may further contain a sweetening agent (0 to 1% by weight, preferably 0.001 to 1%) such as saccharin sodium, stevioside, and aspartame.
0.5% by weight), and if necessary, a dye and other components can be blended, and the desired component can be produced by mixing with an appropriate amount of water.

Further, in the present invention, tranexamic acid,
Antiplasmin agents such as epsilon aminocaproic acid, ascorbic acid, vitamins such as tocopherol esters,
Glycyrrhizin salts, allantoins, oak, ogre, chamomile, ratania, myrrh, etc., plant extracts, enzymes such as dextranase, mutanase, lysozyme chloride, alkali metal monofluorophosphates such as sodium monofluorophosphate, sodium fluoride , Fluorides such as stannous fluoride, sodium chloride, potassium nitrate,
One or more active ingredients such as carbonates, bicarbonates, sesquicarbonates, and the like, copper chlorophyllin sodium, copper gluconate, zinc chloride, zeolites, water-soluble inorganic phosphate compounds, and aluminum lactate can be blended. . The amount is usually
An appropriate amount may be added in consideration of effectiveness and palatability, that is, 0.001 to 10% by weight, and more preferably 0.005 to 2% by weight.

[0018]

EFFECTS OF THE INVENTION The liquid oral composition according to the present invention is a liquid oral composition containing a polyhydric alcohol, a nonionic surfactant and, if necessary, ethanol, comprising xanthan gum, carrageenan, alginate and polyacrylate. By blending one or more polymer substances selected from the group consisting of 0.001 to 0.04% by weight, it is possible to remove fat and oil stains in the oral cavity without irritating the oral mucosa. You can do it.

[0019]

EXAMPLES The present invention will be described below in detail with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples.

Examples 1 to 12 and Comparative Examples 1 to 10 Liquid oral compositions having the compositions shown in Tables 1 and 2 were prepared and evaluated for detergency and viscosity. In addition, the thing of the composition shown in Table 3 was used for the fragrance. <Evaluation of Detergency by Model System> The evaluation of detergency against oil and fat stains in the oral cavity was performed by the model system. A collagen membrane was used as a model of the oral mucosa, and a stain used in the method for evaluating the detergency of a synthetic detergent specified in JIS K 3370 was used as a model of fat and oil stain.

A mixture of soybean oil, beef tallow, and oil red is dissolved in chloroform, and this is used as dirt. The washed and dried collagen film is cut into a size of 35 mm × 40 mm, and dirt is adhered to both sides. Take 100 ml of liquid oral composition,
After immersing the above collagen membrane and shaking for 30 seconds,
Wash with deionized water. The dirt remaining on the collagen membrane is extracted with chloroform, and the absorbance of oil red at the maximum absorption wavelength is measured. Calculate the ratio with the absorbance in the blank test, and use it as the grease stain removal rate.

<Sensory Evaluation of Detergency> Sensory evaluation was performed on the feeling of stain removal in the oral cavity by five specialized panels. Immediately after eating a normal lunch, 10 ml of the liquid oral composition was contained in the mouth, and the mouth was washed for 30 seconds. The feeling of stain removal in the oral cavity immediately after ejection was evaluated by a sensory test. The results were evaluated on a 5-point scale according to the following criteria, and the average value of 5 persons was shown. 1: No feeling of dirt removal 2: Very little feeling of dirt 3: Some feeling of dirt 4: Some feeling of dirt 5: Very feeling of dirt

Tables 1 and 2 show the results of testing the removal rate of grease and grease and the feeling of dirt removal immediately after discharging the liquid oral composition according to the above-mentioned test method.

<Sensory Evaluation of Viscosity> The sensory evaluation of viscosity was performed by a specialized panel. The mouth was filled with 10 ml of the liquid oral composition and washed for 30 seconds. The viscosity of the liquid oral composition during use was evaluated by a sensory test. The results were evaluated on a three-point scale of △ x according to the following criteria. ：: good △: slightly high viscosity, not suitable for use ×: too high viscosity, not suitable for use

<Comprehensive Evaluation> Comprehensive evaluation was performed according to the following criteria. ：: A fat and oil stain removal rate by a model system of 60% or more, a sensory evaluation value of detergency of 4 points or more, and a sensory evaluation of viscosity of ○. X: The removal rate of fats and oils by the model system is less than 60%, the sensory evaluation value of detergency is less than 4 points, or the sensory evaluation of viscosity is Δ or ×.

[0026]

[Table 1] (Note 1) Similar results were obtained when stevioside (0.002% by weight), stevia extract (0.002% by weight), and aspartame (0.005% by weight) were used as sweeteners.

[0027]

[Table 2] (Note 1) Similar results were obtained when stevioside (0.002% by weight), stevia extract (0.002% by weight), and aspartame (0.005% by weight) were used as sweeteners.

[0028]

[Table 3] The numerical values indicate the ratio (% by weight) of the whole fragrance. (Note 2) Similar results were obtained when the flavoring compound was replaced with a strawberry flavor, an apple flavor, a pineapple flavor, a grape flavor, a mango flavor, a tropical fruit flavor, a butter flavor, a milk flavor, and a fruit mix flavor.

As is evident from the results of Tables 1 to 3, the liquid oral composition containing a polyhydric alcohol, a nonionic surfactant and ethanol was prepared from a group consisting of xanthan gum, carrageenan, alginate and polyacrylate. By blending one or more selected polymer substances in an amount of 0.001 to 0.04% by weight based on the whole composition, the cleaning power against oil and dirt and the feeling of dirt immediately after discharge are improved. This effect is not seen in the aqueous solution of the polymer alone.

The overall evaluation of the liquid oral compositions shown in the following examples was also ○.

Example 13 Malic acid 0.05% by weight Sodium malate 0.10 Sodium fluoride 0.05 Dextranase 0.05 Methyl paraben 0.10 Xylitol 10.00 Polyoxyethylene (60) hydrogenated castor oil 2 0.001 Polymer (xanthan gum) 0.01 Propylene glycol 2.00 Ethanol 2.00 * 2 Perfume A 0.20 Purified water Remaining total 100.00% by weight * 1 As a polymer, carrageenan, alginic acid instead of xanthan gum Similar results were obtained when salts and polyacrylates were used. * 2 Similar results were obtained when perfume B, C, D, E, F, and G were used instead of perfume A.

Example 14 Sodium Phosphate Anhydrous 0.21% by Weight Potassium Dihydrogen Phosphate 0.20 Sodium Monofluorophosphate 0.05 Cetylpyridinium Chloride 0.01 Stevia Extract 0.002 Polyoxyethylene ( 30) Cetyl ether 1.50 * 1 Polymer (carrageenan) 0.03 Polyethylene glycol # 400 5.00 Ethanol 10.00 * 2 Perfume B 0.20 Purified water Remaining total 100.00% by weight * 1 As polymer Similar results were obtained when xanthan gum, alginate, and polyacrylate were used instead of carrageenan. * 2 Similar results were obtained when perfume A, C, D, E, F, and G were used instead of perfume B.

Example 15 Citric acid 0.10% by weight Sodium citrate 0.20 Tocopherol acetate 0.10 Benzethonium chloride 0.01 Sodium benzoate 0.20 Sodium saccharin 0.01 Polyoxyethylene (40) stearyl ether 2 .50 * 1 Polymer (sodium alginate) 0.02 Glycerin 7.00 Ethanol 10.00 * 2 Perfume C 0.20 Purified water Remaining total 100.00% by weight * 1 As a polymer, xanthan gum is used instead of sodium alginate. Similar results were obtained when carrageenan and polyacrylate were used. * 2 Similar results were obtained when perfume A, B, D, E, F, and G were used instead of perfume C.

Example 16 Sodium chloride 2.00% by weight Epsilon aminocaproic acid 0.05 Benzalkonium chloride 0.01 Sodium benzoate 0.20 Saccharin sodium 0.01 Polyoxyethylene (60) hydrogenated castor oil 1.00 * 1 Polymer (sodium polyacrylate) 0.04 Propylene glycol 5.00 Ethanol 10.00 * 2 Perfume D 0.20 Purified water Remaining total 100.00% by weight * 1 As a polymer, instead of sodium polyacrylate Similar results were obtained with xanthan gum, carrageenan, and alginate. * 2 Similar results were obtained when perfume A, B, C, E, F, and G were used instead of perfume D.

Example 17 Aluminum Lactate 2.00% by Weight Sodium Hydroxide 0.10 Propyl Paraben 0.02 Ethyl Paraben 0.03 Saccharin Sodium 0.01 Polyoxyethylene (60) Hardened Castor Oil 1.00 * 1 Polymer (Xanthan gum) 0.03 Glycerin 20.00 Ethanol 7.00 * 2 Perfume E 0.20 Purified water Remaining total 100.00% by weight * 1 As a polymer, carrageenan, alginate, and polyacrylate are used instead of xanthan gum. Similar results were obtained when used. * 2 Similar results were obtained when perfume A, B, C, D, F, and G were used instead of perfume E.

Example 18 Sodium hydrogen carbonate 2.00% by weight Sodium carbonate 1.20 Methyl paraben 0.10 Aspartame 0.005 Polyoxyethylene polyoxypropylene copolymer 2.00 * 1 Polymer (carrageenan) 02 Erythritol 5.00 Ethanol 5.00 * 2 Fragrance F 0.20 Purified water Remaining total 100.00% by weight * 1 When using xanthan gum, alginate, or polyacrylate instead of carrageenan as the polymer, Similar results were obtained. * 2 Similar results were obtained when perfume A, B, C, D, E, and G were used instead of perfume F.

Example 19 Malic Acid 0.10% by Weight Sodium Malate 0.20 Copper Gluconate 0.01 Chlorhexidine Gluconate 0.01 Sodium Benzoate 0.20 Sodium Saccharin 0.005 Food Color Blue No. 1 Minor Edible Pigment Yellow No. 4 trace amount sorbitan monostearate 1.50 * 1 polymer (sodium alginate) 0.01 concentrated glycerin 8.00 ethanol 5.00 * 2 fragrance G 0.20 purified water remaining total 100.00% by weight * 1 Similar results were obtained when xanthan gum, carrageenan, or polyacrylate was used instead of sodium alginate as the polymer. * 2 Similar results were obtained when perfume A, B, C, D, E and F were used instead of perfume G.

Example 20 Zinc chloride 1.00% by weight Methyl paraben 0.10 Sodium benzoate 0.20 Hinokitiol 0.001 Sorbitol 2.00 Stevia extract 0.002 Sucrose palmitate 2.00 * 1 Polymer (Sodium polyacrylate) 0.04 Propylene glycol 5.00 Ethanol 3.00 * 2 Perfume A 0.20 Purified water Remaining total 100.00% by weight * 1 As a polymer, instead of sodium polyacrylate, xanthan gum, kamo Similar results were obtained when laginan and alginate were used. * 2 Similar results were obtained when perfume B, C, D, E, F, and G were used instead of perfume A.

Example 21 Potassium dihydrogen phosphate 0.58% by weight Sodium hydroxide 0.10 Dipotassium glycyrrhizinate 0.02 Isopropyl methyl phenol 0.02 Sodium saccharin 0.003 Polyoxyethylene (80) monooleate 3.00 * 1 Polymer (xanthan gum) 0.01 Maltitol 5.00 Ethanol 10.00 * 2 Perfume B 0.20 Purified water Remaining total 100.00% by weight * 1 As a polymer, instead of xanthan gum, carrageenan, alginate Similar results were obtained when polyacrylate was used. * 2 Similar results were obtained when perfume A, C, D, E, F, and G were used instead of perfume B.

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Claims (1)

[Claims] (1) xanthan gum, carrageenan,
One or more polymer substances selected from the group consisting of alginate and polyacrylate, 0.001 to 0.04% by weight based on the whole composition, (b) a polyhydric alcohol,
(C) A liquid oral composition comprising a nonionic surfactant.