JP2006206581A - Liquid composition for oral cavity - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a liquid composition for the oral cavity, which exhibits excellent usability (dischargeability and retention), storage stability (appearance, pH and viscosity) and thickening effect by a Ca ion and sufficiently exhibits improvement effect on retention of a medicinal component in the oral cavity. <P>SOLUTION: The liquid composition for the oral cavity comprises (A) an alginate that has 5-100 mPa s viscosity of 1.0% by mass of an aqueous solution at 20&deg;C and has the content ratio of (M/G ratio) of D-mannuronic acid to L-guluronic acid in the molecule of 0.5-2.0 (mass ratio), (B) xanthan gum, (C) a phosphate represented by general formula (1) M<SB>n</SB>H<SB>3-n</SB>PO<SB>4</SB>(M is Na or K; n is 1, 2 or 3) and (D) water and has the mass ratio of (A) alginate/(B) xanthan gum of 1.0-12.0 and pH 6.0-8.5 at 25&deg;C. <P>COPYRIGHT: (C)2006,JPO&amp;NCIPI

Description

  The present invention is a liquid oral composition in which the usability and storage stability of the composition are particularly good, the thickening effect by calcium ions is exhibited, and further, the improvement effect in the oral retention of medicinal components is exhibited. It is about. More specifically, the present invention relates to a liquid oral composition suitable for interdental parts applied by an interdental brush or for application to a cervical part or gingiva applied by a finger.

  Alginic acid is a hydrophilic polymer compound obtained by extracting and purifying brown algae such as Kajime, Arame, Kelp, Macrosystemis, Ascophyllum, Echronia Maxima, and Lessonia by chemical operation. A polymer of -1,4-bonded D-mannuronic acid [M] and α-1,4-bonded L-guluronic acid [G], wherein the polymerization degree of alginic acid and intramolecular D-mannuronic acid and L -The content ratio of guluronic acid (hereinafter abbreviated as M / G ratio) varies depending on the type and part of the raw material, the extraction method, and the like.

  As such alginic acid or a salt thereof, those having physical properties suitable for toothpaste binders, dental impression agents, food stabilizers, printing pastes and the like have been used. As a technique for blending alginic acid or a salt thereof into a liquid oral composition such as a mouthwash or a liquid dentifrice, a composition that suppresses the formation of plaque by sodium alginate (Patent Document 1: JP-A-1-213222), By blending alginic acid having an M / G ratio of 0.2 to 1 or a salt thereof, the formation of dental plaque is suppressed, and further by blending alginic acid or a salt thereof having an average degree of polymerization of 800 to 1,500. A composition having an excellent effect of inhibiting bacterial adhesion (Patent Document 2: JP-A-4-36228) and a water-soluble polymer such as algin sodium and xanthan gum as a dispersant, and having a viscosity of 1 to 1,800 mPa · s. Dispersion stability of the abrasive by adjusting to a range of (25 ° C.) and further blending one or more water-soluble hydrogen phosphate compounds, hydrogen carbonate compounds, and hydrogen sulfate compounds. A mouthwash composition that improves and exhibits an excellent cleaning effect (Patent Document 3: Japanese Patent Application Laid-Open No. 10-167940), and contains a combination of water-soluble polymers such as tara gum, sodium algin, and xanthan gum for cleaning. Liquid oral composition (Patent Document 14: Japanese Patent Application Laid-Open No. 2004-217570) that is highly practical and has improved palatability by suppressing stickiness after mouthwashing, and an oral composition that contains xanthan gum and is alkaline In JP-A No. 11-71250, a composition in which liquid separation of the preparation is improved by blending an alginate is known.

  In addition, bactericides or anti-inflammatory agents are blended as active ingredients in oral compositions such as mouthwashes and liquid dentifrices, and techniques for preventing oral diseases such as caries and periodontal diseases are well known, and triclosan is blended In the oral composition, triclosan was retained in the oral cavity by blending alginic acid having a mass ratio (M / G ratio) of mannuronic acid and guluronic acid of 1 or less and water-soluble polymers such as salts thereof. Composition (Patent Document 5: JP-A-4-139118), combined use of sodium alginate and xanthan gum further improves the retention of triclosan in the oral cavity and improves the stability (liquid separation) of the preparation. A known composition (Patent Document 6: Japanese Patent Laid-Open No. 7-187975) is known. Furthermore, a composition in which the retention in the oral cavity of menthol is enhanced by blending a water-soluble polymer such as sodium alginate or xanthan gum with a mouthwash containing no abrasive (Patent Document 7: JP-A-8-333227) It has been known.

  However, when a medium to high viscosity alginic acid or salt thereof conventionally used for oral products such as toothpaste is used as a viscosity modifier in a liquid oral composition, the viscosity of the liquid oral composition is In a composition that does not contain a pH adjuster and is not maintained near neutrality, the viscosity is significantly reduced during storage, which is a major problem in the quality of the preparation.

  In addition, in a liquid composition that uses sodium alginate and xanthan gum in combination, and does not contain an appropriate amount of phosphate, citrate, etc., the solubility of the water-soluble polymer is poor and the water-soluble polymer precipitates during storage. Or a significant problem in the quality of the preparation, such that a suitable viscosity does not appear.

  Furthermore, an acidic oral composition (patent document 8: Japanese translations of PCT publication No. 2002-524401) in which a viscosity-adjusting polymer substance such as alginate and xanthan gum is blended and the effective pH is adjusted to 4.5 or less is known. However, when the pH of the liquid composition containing an alginate is lower than 6.0, the viscosity is remarkably lowered, which causes a serious problem in quality.

  On the other hand, it is generally known that alginic acid or a salt thereof gels (thickens) by a crosslinking reaction with a metal ion such as calcium. Further, it is known that the gelation ability and gel strength of alginic acid are greatly influenced by the content ratio and arrangement method of M and G, and when the G ratio is high, the gel strength is high (Non-patent Document 1). : FRAGRANCE JOURNAL 1994-4, 76-84). Regarding the influence of molecular weight, it is also known that when the M / G ratio, concentration, and G content are the same, the gelling ability and gel strength increase as the molecular weight increases. As a composition characterized by the gelation ability of alginic acid, a technique of blending an alginic acid derivative having an M / G ratio of 1.0 or less with phosphoric acid and a salt thereof is known. The present invention relates to a technique in which thickening of a composition occurs when it comes into contact with a liquid derived from a living body such as saliva or saliva, and enables retention of medicinal components at an application site (Patent Document 9: Japanese Patent Application Laid-Open No. 2002-332248) .

  However, it is possible to suppress the decrease in the viscosity of the composition to some extent by blending phosphate and maintaining the formulation pH in the vicinity of neutrality, but the medium viscosity to high viscosity that have been used in conventional oral products When alginic acid or a salt thereof is used, a decrease in viscosity during storage cannot be completely suppressed. In addition, when low viscosity alginic acid or a salt thereof is used alone as a viscosity modifier, it is necessary to blend alginic acid or a salt thereof at a high concentration in order to give the composition a certain degree of viscosity from the viewpoint of usability. However, in such a composition, when it comes into contact with a liquid derived from a living body, sufficient thickening does not occur, and as a result, the effect of improving the retention of the medicinal component in the oral cavity is insufficient.

  Moreover, the composition (patent document 10: Unexamined-Japanese-Patent No. 5-39213) which mix | blended alginic acid or its salt with an average M / G ratio of 0.2-1 and water-soluble polyphosphoric acid, an average molecular weight is 1,000- Composition comprising an anionic polysaccharide such as 100,000 sodium alginate and xanthan gum and polyphosphate (Patent Document 11: JP-A-8-40859), water-soluble polyphosphate, orthophosphate and amphoteric surface activity Liquid dentifrice in which a composition containing an agent is blended with alginic acid or a salt thereof as a binder (Patent Document 12: JP-A-9-12437, Example 5), an average molecular weight of 1,000 to 100,000 A composition containing an anionic polysaccharide such as sodium alginate or xanthan gum and a divalent metal ion (Patent Document 13: JP-A-9-175968) In addition, a composition containing a phosphate in a mouthwash containing sodium alginate (Patent Document 7: JP-A-8-333227, Examples 20 and 21) and the like are known, but polyphosphate, calcium When a divalent metal ion such as magnesium or magnesium is blended or a water-soluble phosphate is blended at a high concentration, thickening of the composition is remarkably inhibited or not expressed. As a result, the improvement effect in the oral cavity retention property of a medicinal component is not exhibited. In addition, a composition containing a divalent metal ion is a serious problem in terms of appearance stability, such as partial gelation during storage or significant drought.

JP-A-1-213222 JP-A-4-36228 Japanese Patent Laid-Open No. 10-167940 JP-A-11-71250 JP-A-4-139118 JP-A-7-187975 JP-A-8-333227 Special Table 2002-524401 JP 2002-332248 A Japanese Patent Laid-Open No. 5-39213 JP-A-8-40859 Japanese Patent Laid-Open No. 9-12437 JP-A-9-175968 JP 2004-217570 A FRAGRANCE JOURNAL 1994-4, 76-84

  The present invention has been made in view of the above circumstances, the usability and storage stability of the composition is good, the thickening effect by calcium ions is sufficiently expressed, and further the improvement effect on the oral retention of medicinal components An object of the present invention is to provide a liquid composition for oral cavity in which is sufficiently exhibited.

As a result of studying a liquid oral composition containing an alginate in order to achieve the above object, the present inventor has found that a viscosity of a 1.0 mass% aqueous solution at 20 ° C. is 5 to 100 mPa · s. Salt and the following general formula (1)
_{M n H 3-n PO 4} (1)
(However, M represents Na or K, and n is 1, 2 or 3.)
It was found that a decrease in viscosity can be effectively suppressed even under high-temperature storage by blending a phosphate represented by formula (II) and adjusting the pH at 25 ° C. to a range of 6.0 to 8.5. However, in a composition in which a low-viscosity alginate as a viscosity modifier is blended alone within a specific blending amount range, a thickening effect by a crosslinking reaction with a sufficient divalent metal ion such as calcium (hereinafter referred to as Ca ion) (It is abbreviated as a thickening effect due to the above), but the viscosity of the preparation is too low, making it difficult to put an appropriate amount of the preparation on a toothbrush, etc., or dripping down before the preparation is transported to the application site There is a problem with this aspect. In addition, when a low-viscosity alginate is blended at a high concentration so as to have the desired viscosity, the above usability problem is improved, but in a composition containing a high concentration of alginate, Ca ions are used. The thickening effect is not fully exhibited. Furthermore, the improvement effect in the oral cavity retention property of a medicinal component is not exhibited.

  Therefore, in a liquid oral composition containing a low-viscosity alginate, the usability and storage stability are good, and an excellent thickening effect due to Ca ions is exhibited. There has been a demand for the development of a composition that sufficiently exhibits the improvement effect.

For this reason, as a result of further intensive studies in order to meet this demand, the present inventor has (A) a viscosity of 5 to 100 mPa · s of a 1.0 mass% aqueous solution at 20 ° C., and an intramolecular D- Alginates having a content ratio (M / G ratio) of mannuronic acid and L-guluronic acid of 0.5 to 2.0 (mass ratio), (B) xanthan gum, (C) the following general formula (1)
_{M n H 3-n PO 4} (1)
(However, M represents Na or K, and n is 1, 2 or 3.)
And (D) water is blended and the pH at 25 ° C. is in the range of 6.0 to 8.5, and a thickening effect due to excellent Ca ions is expressed. Furthermore, in order to fully exhibit the improvement effect in the oral cavity retention property of a medicinal component, (A) alginate is 0.4 to 2.0 mass%, (B) xanthan gum is 0.1 to 0.6 mass%. Furthermore, (C) 0.03-0.6 mass% of the phosphate represented by the above general formula (1), (D) 45-90 mass% of water, and (A) alginate / (B) By mix | blending the mass ratio of a xanthan gum in the range of 1.0-12.0, the usability | use of a formulation and storage stability are favorable, and the thickening effect by the outstanding Ca ion expresses, Furthermore, A liquid oral composition that sufficiently exhibits the effect of improving the retention of medicinal components in the oral cavity And it found that is, the present invention has been accomplished.

Accordingly, in the present invention, (A) the viscosity of a 1.0 mass% aqueous solution at 20 ° C. is 5 to 100 mPa · s, and the content ratio (M / G ratio) of D-mannuronic acid and L-guluronic acid in the molecule 0.5 to 2.0 (mass ratio) alginate 0.4 to 2.0 mass%,
(B) 0.1 to 0.6% by mass of xanthan gum,
(C) The following general formula (1)
_{M n H 3-n PO 4} (1)
(However, M represents Na or K, and n is 1, 2 or 3.)
0.03-0.6% by mass of a phosphate represented by
(D) 45-90 mass% of moisture
And the mass ratio of (A) alginate / (B) xanthan gum is in the range of 1.0 to 12.0, and the pH at 25 ° C is in the range of 6.0 to 8.5. A liquid oral composition is provided. In this case, (E) a fluorine compound selected from sodium fluoride and sodium monofluorophosphate and / or (F) a glycyrrhizinate such as tranexamic acid, epsilon aminocaproic acid, dipotassium glycyrrhizinate, ascorbic acid or a salt thereof. Containing at least one anti-inflammatory agent, and (G) an anti-inflammatory agent selected from glycyrrhetinic acid and dl-α-tocophenol acetate and / or isopropylmethylphenol, triclosan, hinokitiol, cetylpyridinium chloride, chloride It preferably contains a disinfectant selected from benzethonium chloride, benzalkonium chloride, chlorhexidine gluconate, chlorhexidine gluconate, and (H) a nonionic surfactant and / or ethanol, and more suitable by an interdental brush. It is preferable to prepare as cervical margin or gum coating product is applied by product or finger gullet is.

  According to the liquid oral cavity composition of the present invention, it exhibits excellent usability (dischargeability, retention), storage stability (appearance, pH, viscosity) and a thickening effect due to Ca ions. The effect of improving the retention in the oral cavity can be sufficiently exhibited.

Hereinafter, the present invention will be described in more detail. The liquid oral composition of the present invention is
(A) alginate,
(B) xanthan gum,
(C) phosphate,
(D) Water is contained as an essential component.

  Specific examples of the component (A) alginate include sodium salt, potassium salt, triethanol salt and ammonium salt of alginic acid. The alginate is preferably water-soluble, in particular, water-soluble and commercially available sodium alginate and potassium alginate are preferably used, and sodium alginate is more preferably used. For example, sodium alginate and potassium alginate are commercially available from Kibun Food Chemifa Co., Ltd., Kimika Co., Ltd., Fuji Chemical Industry Co., Ltd., Kelco, Sigma, PRONOVA biopolymer, etc.

  The alginate used in the present invention has a usability of discharging an appropriate amount from a container or holding it on an interdental brush or finger, storage stability (appearance, pH, viscosity) of the preparation, and increase by Ca ions. The viscosity of a 1.0 mass% aqueous solution at 20 ° C. is a Brookfield type viscometer (BM type viscometer, rotor No. 1, rotation speed 30 rpm, from the viewpoint of improving the viscosity effect and further improving the retention of medicinal components in the oral cavity. , After 60 seconds of rotation), it is 5 to 100 mPa · s, preferably 8 to 50 mPa · s, more preferably 10 to 30 mPa · s. When the viscosity exceeds 100 mPa · s, the thickening effect due to Ca ions is excellent, but since decomposition during high-temperature storage occurs remarkably, it becomes a big problem in appearance stability and viscosity stability. Moreover, the thing less than 5 mPa * s cannot fully exhibit the thickening effect by Ca ion, and also does not exhibit the sufficient improvement effect in the oral cavity retention property of a medicinal component.

  Furthermore, the alginate in the present invention has an M / G ratio from the viewpoint of the storage stability (appearance, pH, viscosity) of the preparation, the thickening effect by Ca ions, and the improvement in the oral retention of medicinal components. The thing of 0.5-2.0 is used. Preferably, the M / G ratio is 0.6 to 1.7, more preferably the M / G ratio is 0.7 to 1.5. When the M / G ratio exceeds 2.0, the storage stability (appearance, viscosity) and the thickening effect due to Ca ions are low, and further, the sufficient improvement effect in the oral retention of the medicinal component is not exhibited. When the M / G ratio is less than 0.5, the thickening effect due to Ca ions is high, but the liquid composition used in combination with xanthan gum may cause partial gelation during storage, or a problem in appearance stability. It may become.

  The blending amount of alginate is 0.4 to 2.0% by mass of the entire composition from the viewpoint of the appearance stability of the preparation, the thickening effect due to Ca ions, and the improvement effect on the retention of the medicinal component in the oral cavity. Yes, preferably 0.6 to 1.6 mass%, more preferably 0.7 to 1.2 mass%. When outside the range of 0.4 to 2.0 mass%, the thickening effect due to Ca ions of the liquid composition is not sufficiently exhibited, and further, the sufficient improvement effect in the oral retention of the medicinal component is not exhibited There is. Moreover, in the composition used in combination with xanthan gum, if the blending amount exceeds 2.0% by mass, a large problem in appearance stability such as precipitation of a water-soluble polymer may occur.

  Next, the xanthan gum as the component (B) in the present invention is a polysaccharide obtained by fermenting hydrocarbons using Xanthomonas campestris, and is mainly composed of D-glucose, D-mannose and D-glucuronic acid. It consists of sodium, potassium and calcium salts, and is commercially available from Kelco under the trade names such as Echo Gum, Monato Gum, Keldent and Celtrol. Among these, monate gum DA, keldent, echo gum T, and celtrol T are preferably used, and monate gum DA and keldent are more preferably used. The xanthan gum used in the present invention was measured for the viscosity (Brookfield viscometer, 25 ° C., rotor No. 3, rotation speed 60 rpm, after 30 seconds of rotation) by the method defined in the section of Pharmaceutical Additive Standard 2003 “Xanthan Gum”. 600 to 2,000 mPa · s. If it is less than 600 mPa · s, it is difficult to give the composition a sufficient viscosity, and there is a problem in terms of usability in that an appropriate amount is discharged from the container or held on the interdental brush or finger. There is a case. Moreover, when it exceeds 2,000 mPa · s, there may be a problem in terms of usability of discharging an appropriate amount from the container or usability such as stickiness in the oral cavity.

  The amount of xanthan gum blended is the usability of discharging an appropriate amount from a container or holding it on an interdental brush or finger, the appearance stability of the preparation, the thickening effect by Ca ions, and the oral cavity of medicinal ingredients From the point of the improvement effect in a retention property, it is 0.1-0.6 mass%, Preferably it is 0.15-0.5 mass%, More preferably, it is 0.2-0.4 mass%. If it is less than 0.1% by mass, the viscosity of the preparation in which the low-viscosity alginate is used in the range of 0.4 to 2.0% by mass is extremely low, so in terms of usability (dischargeability, retention). Insufficient medicinal ingredients that cause problems, and that the thickening effect due to Ca ions is sufficiently exerted, but because the viscosity is extremely low, the composition is immediately washed away in the oral cavity environment where saliva is present In some cases, the effect of improving the staying property is not exhibited. When the amount exceeds 0.6% by mass, a problem occurs in terms of usability of discharging an appropriate amount from the container, and the thickening effect due to Ca ions of the composition may be significantly impaired. In some cases, sufficient improvement in oral retention may not be exhibited. In addition, in a liquid composition used in combination with an alginate, if the blending amount exceeds 0.6% by mass, a large problem in appearance stability such as precipitation of a water-soluble polymer may occur.

  The mass ratio of (A) alginate / (B) xanthan gum depends on the usability of discharging an appropriate amount from a container or holding it on an interdental brush or finger, the appearance stability of the preparation, and Ca ions. From the point of the thickening effect and the improvement effect in the oral cavity retention property of a medicinal component, 1.0-12.0 is good, Preferably it is 1.5-7.0, More preferably, it is 2.0-5.0. Good. If the mass ratio is less than 1.0, the thickening effect due to Ca ions may not be sufficiently exhibited, and further, the sufficient improvement effect may not be exhibited in the oral retention of the medicinal component. Moreover, in the formulation which used together the low-viscosity alginate in the range of 0.4-2.0 mass%, a malfunction may arise in terms of usability (dischargeability). When the mass ratio exceeds 12.0, a large problem in appearance stability such as precipitation of a water-soluble polymer may occur, or the thickening effect due to Ca ions may not be sufficiently exhibited. May not exhibit a sufficient improvement effect in the oral retention of the medicinal component. Moreover, in the formulation which used a low-viscosity alginate together in the range of 0.4-2.0 mass%, a malfunction may arise in terms of usability (discharge property, retention property).

The following general formula (1) of the component (C) in the liquid oral cavity composition of the present invention
_{M n H 3-n PO 4} (1)
(However, M represents Na or K, and n is 1, 2 or 3.)
Specific examples of the phosphate represented by the formula include sodium monohydrogen phosphate, potassium monohydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, trisodium phosphate, and the like. You may mix | blend a seed or more. In particular, it is preferable to use sodium monohydrogen phosphate, sodium dihydrogen phosphate, or trisodium phosphate.

  In the present invention, the blending amount of the phosphate of formula (1) is the storage stability (appearance, pH, viscosity) of the preparation, the thickening effect by Ca ions, and the improvement effect on the oral retention of the medicinal component. Therefore, it is 0.03-0.6 mass% of the whole composition, Preferably it is 0.05-0.4 mass%, More preferably, it is 0.08-0.2 mass%. If it is less than 0.03% by mass, the pH stability is low, and as a result, the viscosity of the composition may be significantly reduced. In addition, alginate and / or xanthan gum may be insolubilized and deposited during storage, or there may be a problem in appearance stability. If it exceeds 0.6% by mass, the composition may be noticeably discolored under high-temperature storage or may cause a problem in appearance stability. Moreover, the thickening effect by Ca ion of a composition may be impaired remarkably, and also sufficient improvement effect may not be exhibited in the oral cavity retention property of a medicinal component.

  The water content of the component (D) in the liquid oral composition of the present invention is the entire composition in terms of the appearance stability of the preparation and the thickening effect due to Ca ions, and further the improvement effect in the oral retention of the medicinal component. It is 45-90 mass%. Preferably it is 50-80 mass%, More preferably, it is 55-75 mass%. If it is less than 45% by mass, a large problem in appearance stability such as precipitation of a water-soluble polymer may occur, or the thickening effect due to Ca ions of the composition may not be sufficiently exerted. In some cases, sufficient improvement in oral retention is not exhibited.

  In the present invention, it is also possible to add a fluorine compound, an anti-inflammatory agent or a bactericidal agent to impart retention of the medicinal component in the oral cavity. That is, the liquid oral composition of the present invention thickens by reaction with the oral saliva component, and the medicinal component stays in the oral cavity, so that the action of the medicinal component can be continuously exerted at the application site. It becomes possible.

  In addition, by using the liquid composition of the present invention, it becomes possible to improve the effectiveness due to retention of medicinal components, so the amount of medicinal components to be added to the composition corresponding to the improvement in effectiveness is reduced. It becomes possible to do. As a result, not only can the cost of the contents be reduced, but also the amount of ingredients to be blended to stabilize the medicinal ingredients can be reduced, and the flavor derived from the raw material (bitter taste etc.) may lead to improvement.

  Examples of the fluorine compound include sodium fluoride and sodium monofluorophosphate, and sodium monofluorophosphate is particularly preferably used. It is important to set the blending amount of the fluorine compound within the range of the proper blending amount from the viewpoint of effectiveness and the thickening effect by Ca ions, and further the improvement effect of the medicinal component in the oral cavity retention.

  For example, the blending amount of sodium fluoride is preferably 0.01 to 0.2% by mass of the total composition, more preferably 0.02 to 0.1% by mass, and further 0.03 to 0.08% by mass. preferable. If it is less than 0.01% by mass, it is not satisfactory in terms of effectiveness, and if it exceeds 0.2% by mass, the thickening effect due to Ca ions of the composition may not be sufficiently exerted. There may be a case where a sufficient improvement effect is not exhibited in the oral retention of components.

  The blending amount of sodium monofluorophosphate is preferably 0.04 to 0.8 mass%, more preferably 0.07 to 0.4 mass%, further 0.1 to 0.25 mass% of the entire composition. preferable. If it is less than 0.04% by mass, it is not satisfactory in terms of effectiveness, and if it exceeds 0.8% by mass, the thickening effect due to Ca ions of the composition may not be sufficiently exhibited. There may be a case where a sufficient improvement effect is not exhibited in the oral retention of the component.

  Moreover, viscosity stability can be further improved by blending the fluorine compound into the liquid composition of the present invention.

Anti-inflammatory agents include water-soluble tranexamic acid, epsilon aminocaproic acid, glycyrrhizinates such as dipotassium glycyrrhizinate, ascorbic acid or salts thereof such as ascorbic acid or sodium ascorbate, poorly water-soluble glycyrrhetic acid, dl-α-acetate Examples include tocophenol (vitamin E), and it is preferable to use tranexamic acid, epsilon aminocaproic acid, dipotassium glycyrrhizinate and glycyrrhetinic acid, particularly preferably dipotassium glycyrrhizinate and glycyrrhetinic acid.
0.005-1.0 mass% of the whole composition is good, as for the compounding quantity of an anti-inflammatory agent, 0.01-0.5 mass% is more preferable, and 0.02-0.2 mass% is still more preferable.

Bactericides include isopropylmethylphenol, triclosan, hinokitiol, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, chlorhexidine gluconate, chlorhexidine hydrochloride, isopropylmethylphenol, triclosan, hinokitiol, cetylpyridinium chloride, benzethonium chloride, Benzalkonium chloride is preferably used, and isopropylmethylphenol, triclosan, and cetylpyridinium chloride are particularly preferably used.
0.005-0.5 mass% of the whole composition is good, as for the compounding quantity of a disinfectant, 0.01-0.3 mass% is more preferable, and 0.02-0.1 mass% is still more preferable.

  The composition of the present invention contains a fluorine compound such as sodium fluoride or sodium monofluorophosphate or a water-soluble anti-inflammatory agent such as tranexamic acid, epsilon aminocaproic acid, dipotassium glycyrrhizinate, ascorbic acid or ascorbate. In the composition, even when a nonionic surfactant and / or ethanol is not blended, the effect of the present invention is exhibited.

  On the other hand, from an anti-inflammatory agent selected from glycyrrhetinic acid and dl-α-tocophenol acetate (vitamin E), isopropylmethylphenol, triclosan, hinokitiol, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, chlorhexidine gluconate, chlorhexidine hydrochloride When blending at least one selected fungicide, it is necessary to blend a nonionic surfactant and / or ethanol. Solubilizing poorly water-soluble anti-inflammatory agents such as glycyrrhetinic acid, and solubilizing water-insoluble fungicides such as isopropylmethylphenol and triclosan in the formulation, preventing adsorption to container materials such as container stoppers, or cetylpyridinium chloride It is for preventing a cationic disinfectant such as whitening in a preparation containing alginate and xanthan gum.

  Various conventionally known surfactants can be used as the nonionic surfactant. For example, polyoxyethylene fatty acid ester such as polyoxyethylene hydrogenated castor oil, sucrose fatty acid ester such as sucrose fatty acid ester, maltose fatty acid ester, sugar alcohol fatty acid ester such as maltitol fatty acid ester, lactol fatty acid ester, alkylol amide, Polyoxyethylene sorbitan monostearate and other polyoxyethylene sorbitan fatty acid esters, sorbitan fatty acid esters, glycerin fatty acid esters, polyglycerin fatty acid esters, polyoxyethylene glycerin fatty acid esters, polyoxyethylene glycol fatty acid esters, polyethylene glycol fatty acid esters, polyoxy Fatty acid diethanolamine such as ethylene polyoxypropylene glycol, lauric acid mono- or diethanolamide , Polyoxyethylene alkyl ethers, polyoxyethylene alkyl phenyl ether, and the like.

  In particular, from the viewpoint of the purpose and taste of solubilizing poorly water-soluble anti-inflammatory agents, bactericides, and fragrance components, and as a result, exerting the retention effect of medicinal components and improving storage stability (appearance stability) Polyoxyethylene polyoxypropylene glycol having an average addition mole number of ethylene oxide of 30 to 300 and an average addition mole number of propylene oxide of 30 to 70, polyoxyethylene curing having an average addition mole number of ethylene oxide of 40 to 120 Castor oil, preferably a polyoxyethylene alkyl ether having an alkyl group with a carbon chain length of 16 to 18 and an average addition mole number of ethylene oxide of 10 to 50, an average addition mole number of ethylene oxide of 200 and propylene oxide. Polyoxyethylene polyoxypropylene group having an average added mole number of 70 Polyoxyethylene hydrogenated castor oil having an average addition mole number of coal and ethylene oxide of 60 to 100, polyoxyethylene alkyl ether having an alkyl group carbon chain length of 16 to 18 and an average addition mole number of ethylene oxide of 20 to 50 It is more preferable to use Polyoxyethylene polyoxypropylene glycol is commercially available under the trade names of Pluronic F-88, Pluronic F-108, Pluronic F-127 and Lutrol F-127 from Asahi Denka Kogyo Co., Ltd. and BASF Corporation. Ethylene hydrogenated castor oil is commercially available from Nikko Chemicals Co., Ltd., Nippon Emulsion Co., Ltd. and the like. Polyoxyethylene alkyl ether is commercially available from Nippon Emulsion Co., Ltd., Lion Chemical Co., Ltd.

In addition, the compounding quantity of nonionic surfactant is 0.1-5.0 mass% of the whole composition, especially 0.2-4.0 mass to the grade which does not impair the effect of a liquid oral composition. % Is preferable. For example, when polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 60 is used, 0.1 to 1.5% by mass is preferably blended. When polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 100 is used, it is preferable to blend 0.3 to 4.0% by mass. When a polyoxyethylene alkyl ether having an alkyl group having a carbon chain length of 16 to 18 and an average added mole number of ethylene oxide of 20 to 50 is used, it is preferably blended in an amount of 0.2 to 2.0% by mass.
When the blending amount of the nonionic surfactant is less than 0.1% by mass, it may be difficult to maintain the appearance stability, and when it exceeds 5.0% by mass, the action of the bactericide and / or the anti-inflammatory agent is caused. It may be hindered, taste bad, and the feeling of use may be significantly impaired.

In general, the blending amount of ethanol is preferably 0 to 15% by mass, more preferably 2 to 12% by mass, and particularly preferably 3 to 8% by mass based on the entire composition. When the content exceeds 15% by mass, water-soluble polymers such as alginate and xanthan gum become insoluble, or the composition gels when stored at a low temperature (−10 ° C.) and does not recover even when returned to room temperature. Problems with property stability may occur. Moreover, irritation | stimulation is strong and a usability | use_condition may be impaired remarkably.
Note that the blending amount of ethanol includes a small amount of ethanol in the blended fragrance.

  The composition for liquid oral cavity of the present invention is a liquid toothpaste for normal tooth brushing, a liquid toothpaste for interdental portion applied to an interdental brush or dental floss, a sheet agent such as a finger or a non-woven fabric, and a cervical part or gingiva. A type of product that is applied directly to the interdental part, periodontal pocket, etc. in a container equipped with a thin-pointed nozzle, and a concentrated type that is diluted with water before use. It can be applied to products such as mouthwash and mouthwash. In that case, various components that are usually used in oral compositions can be blended, but the required viscosity, blending component and blending amount differ depending on the dosage form. It is necessary to make the selection in the same manner as in the previous case and to the extent that the effects of the present invention are not hindered.

  For example, in the case of dentifrice, abrasives, wetting agents, viscosity modifiers, surfactants, sweeteners, preservatives, fragrances, colorants, pH adjusters, active ingredients, cleaning aids, etc. are mixed with water. Can be produced according to conventional methods.

  As abrasives, silica-based abrasives such as precipitated silica, silica gel, aluminosilicate, zirconosilicate, dicalcium phosphate (dihydrate or anhydride), primary calcium phosphate, tricalcium phosphate, calcium pyrophosphate, calcium carbonate , Aluminum hydroxide, alumina, magnesium carbonate, tribasic magnesium phosphate, insoluble sodium metaphosphate, insoluble potassium metaphosphate, titanium oxide, zeolite, anhydrous silicic acid, hydrous silicic acid, titanium silicate, zirconium silicate, synthetic resin system An abrasive | polishing agent etc. are mentioned, It is preferable to use a silica type abrasive | polishing agent especially. The compounding quantity is 0-30 mass% normally.

  Examples of the wetting agent include propylene glycol, glycerin, sorbitol, xylitol, maltitol, lactol, erythritol, palatinose, trehalose, polyhydric alcohols such as polyethylene glycol having an average molecular weight of 190 to 9,300, 1,3-butylene glycol, sugar Alcohol etc. are mentioned. Among these, propylene glycol, sorbit, glycerin, and polyethylene glycol having an average molecular weight of 190 to 1,050 are preferably used, and propylene glycol, sorbit, and glycerin are particularly preferably used. The total blending amount is usually 5 to 40% by mass, preferably 8 to 35% by mass, and more preferably 10 to 30% by mass of the entire composition. If the amount is less than 5% by mass, the feeling in use in the oral cavity is deteriorated. If the amount exceeds 40% by mass, the thickening effect by Ca ions of the composition may be significantly impaired. In some cases, the improvement effect on the property is not sufficiently exhibited.

  In the present invention, in addition to the above-mentioned nonionic surfactants, other surfactants can be blended so as not to impair the effect of the liquid oral composition in order to solubilize the poorly water-soluble fragrance component. Specifically, alkyl sulfates, N-acyl sarcosine acids, sodium dodecylbenzenesulfonates, hydrogenated coconut fatty acid sodium monoglyceride monosulfate, sodium lauryl sulfoacetate, N-acyl glutamates such as sodium N-palmitoyl glutamate, N- Anionic surfactants such as sodium methyl-N-acyl taurate, sodium N-methyl-N-acylalanine, sodium α-olefin sulfonate, cationic surfactants such as alkyl ammonium and alkyl benzyl ammonium salts, betaine acetate, Examples include amphoteric surfactants such as imidazolinium betaine. The blending amount is usually preferably 0 to 3% by mass, particularly preferably 0 to 2% by mass, based on the entire composition. If it exceeds 3% by mass, the oral mucosa may be irritated.

  Examples of sweeteners include saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl hydrochalcone, perlartin, glycyrrhizin, thaumatin, asparatylphenylalanine methyl ester, and the like.

  As perfumes, spearmint oil, peppermint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime Natural fragrances such as oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, cinnamon bark oil, menthol, menton, carvone , Ethyl butyrate, vanillin, ethyl maltol, anethole, methyl salicylate, synamic aldehyde, thymol, cineol, eugenol, ethyl vanillin, maltol, limonene, citronellol, linalool, linalyl acetate, menthyl acetate, Single flavors such as nene, octyl aldehyde, citral, pulegone, carbyl acetate, anisaldehyde, ginger oleoresin, creosole, dl-camphor, ethyl acetate, allylcyclohexane propionate, methyl anthranilate, ethyl methyl phenyl It is possible to use known fragrances used in oral compositions such as singular fragrances such as glycidate, undecalactone, hexanal, ethyl alcohol, propyl alcohol, butanol, isoamyl alcohol and / or various blended fragrances including natural fragrances. It is possible and it is not limited to the fragrance | flavor of an Example. Moreover, although a compounding quantity is not specifically limited, It is preferable to use 0.01-1 mass% of one fragrance | flavor raw material in a composition like many well-known examples.

  In the case of a liquid composition for interdental part applied by an interdental brush or for a cervical part or gingiva applied by a finger, in order to satisfy the feeling of use such as a refreshing feeling and a refreshing feeling at the application site In particular, it is preferable to blend a perfume component selected from mint oil, spearmint oil, peppermint oil, clove oil, menthol, menthone, anethole, eugenol, thymol, cineol and dl-camphor. The blending amount of these fragrance components is usually preferably 0.1 to 0.8% by mass, more preferably 0.2 to 0.7% by mass, and particularly preferably 0.3 to 0.6% by mass. When the amount is less than 0.1% by mass, the refreshing feeling and the refreshing feeling at the application site are insufficient, so that it is not satisfactory in terms of actual use. The feeling of irritation is strong and the feeling of use may worsen.

  As colorants, Red No. 2, Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 204, Green No. 3 etc. Legal dye, caramel dye, safflower dye, gardenia dye, cochineal dye, anato dye, mica titanium, titanium oxide and the like.

  As the antiseptic, benzoic acid and its salt, salicylic acid and its ester or salt, parabens, phenol and the like can be used as necessary in addition to the above bactericides.

  As active ingredients, fluorine compounds other than sodium fluoride and sodium monofluorophosphate, ascorbic acid-2-phosphate other than ascorbic acid or a salt thereof, ascorbic acid derivatives such as ascorbic acid sulfate, allantoin and derivatives thereof, Glycyrrhizic acid, tocopherols other than dl-α-tocophenol acetate, pyridoxine hydrochloride (vitamin B6), sodium azulenesulfonate, diclofenac sodium, indomethacin, acemetacin, sulindac, ibuprofen, flurbuprofen, pranoprofen, ketoprofen, phenacetin , Acetaminophen, mefenamic acid, tetrahydrozoline hydrochloride, aminoethylsulfonic acid (taurine), hydrocortisone acetate, diphenhydramine salicylate, Plant extracts such as nazole, ethyl aminobenzoate, buckwheat, auren, hornon, hamamelis, clove, chamomile, latania, myrrh, toki, rosemary, safflower, dextranase, mutanase, lysozyme chloride, amylase, protease, lytic enzyme Enzymes such as superoxide dismutase, augmentin, amoxicillin, tetracycline, doxycycline, minocycline hydrochloride, metronidazole, neomycin, kanamycin, clindamycin and other antibiotics, sodium chloride, potassium nitrate, carbonate, bicarbonate, sesquicarbonate, etc. Salts, α-bisabolol, methoxyethylene maleic anhydride copolymer, epidihydrocholesterine, dihydrocholesterol, trichlorocarbanilide, alanine, glycine, Phosphorus, L- arginine, L- sodium aspartate, trimethylglycine, alkyldiaminoethylglycine hydrochloride, dequalinium chloride, lauroyl sarcosine sodium and the like may be incorporated singly or in combination. The amount of the active ingredient added can be an effective amount as long as the effects of the present invention are not hindered.

  In addition, compositions containing water-soluble divalent metal salts such as calcium and magnesium may gel during storage or may cause significant discoloration. Therefore, calcium and magnesium are used from the viewpoint of appearance and property stability. It is preferable not to add a water-soluble divalent metal salt such as, or to keep it in a very small amount. Polyphosphates and pyrophosphates are preferably not added or kept in a very small amount because the thickening effect due to Ca ions is remarkably impaired.

  Further, the pH at 25 ° C. of the liquid oral composition of the present invention is in the range of 6.0 to 8.5, preferably 6.3, from the viewpoint of the storage stability (appearance, pH, viscosity) of the preparation. It is -8.0, More preferably, it is the range of 6.6-7.7. If it is less than 6.0, the viscosity stability of the composition is remarkably lowered, and this causes a serious problem in quality. If it exceeds 8.5, discoloration of the composition becomes remarkable, resulting in problems in appearance stability. In addition, a composition containing a fragrance component is not preferable because it may cause quality problems such as significant deterioration of flavor and may cause damage to the oral mucosa. Here, as a means for adjusting the pH to the range of 6.0 to 8.5, a method of blending the above phosphates alone or in combination of two or more thereof, phosphoric acid, hydrochloric acid, sodium hydroxide, carbonic acid The method of using together with other pH adjusters, such as sodium and sodium hydrogencarbonate, is mentioned. In particular, a combined system of sodium monohydrogen phosphate and sodium dihydrogen phosphate, a combined system of sodium monohydrogen phosphate or trisodium phosphate and hydrochloric acid, a combined system of sodium dihydrogen phosphate and sodium hydroxide or sodium bicarbonate In particular, a combined system of sodium monohydrogen phosphate and sodium dihydrogen phosphate, sodium dihydrogen phosphate and sodium hydrogen carbonate is more preferable.

  Furthermore, the viscosity at 25 ° C. of the liquid oral cavity composition of the present invention is such that the appropriate amount is discharged from the container or held on the interdental brush or finger, and the thickening effect by Ca ions, From the viewpoint of the effect of improving the retention of the medicinal component in the oral cavity, when measured using a Brookfield viscometer (BL type viscometer, rotor No. 1 to 3, rotation speed 12 rpm, after 2 minutes of rotation), 400 It is preferably in the range of ˜8,000 mPa · s, more preferably 600 to 5,000 mPa · s, still more preferably 800 to 3,000 mPa · s, and 800 to 2,000 mPa · s. It is particularly preferred. If it is less than 400 mPa · s, there may be a problem in terms of usability (dischargeability, retention). If it exceeds 8,000 mPa · s, problems may occur in terms of usability (dischargeability), and the thickening effect due to Ca ions of the composition may not be sufficiently exhibited. Furthermore, there is a case where a sufficient improvement effect is not exhibited in the retention of the medicinal component. Moreover, when it is applied to the oral cavity, the dispersibility of the preparation is poor, and the usability may be deteriorated.

  Moreover, there is no restriction | limiting in particular as a container which accommodates this invention composition, Usually, it can be filled and used for the container currently applied to the composition for oral cavity. Specifically as such a container, a polyethylene layer, an ethylene methacrylic acid copolymer layer, a polyethylene terephthalate layer, an aluminum layer, a glass vapor deposition layer, a polyvinyl alcohol layer, an ethylene vinyl alcohol copolymer layer, an acrylonitrile copolymer layer, Laminate containers made of paper, recycled plastic layers, etc., or polyethylene containers, polyethylene terephthalate containers, polypropylene containers, etc. can be used. Tube containers, dispensers containers with mechanical or differential pressure, film packaging containers such as pillow packaging, etc. Various containers usually used as the composition can be used.

Below, usability, storage stability, thickening effect due to Ca ions, and medicinal components using composition examples (Examples) and non-applicable composition examples (comparative examples) corresponding to the liquid oral composition of the present invention Although the experimental example of the improvement effect in a retention property is shown and the characteristic and the outstanding effect of this invention are demonstrated concretely, this invention is not restrict | limited by this Example.
In addition, the viscosity and M / G ratio of sodium alginate were measured by the following method.

[Experiment 1] Measurement of Viscosity of Sodium Alginate Viscosity of sodium alginate was measured according to a known method using a Brookfield viscometer. The sample preparation method is as follows. Into a 300 mL beaker, 198 mL of purified water was poured, and 2.00 g of sodium alginate raw material was added little by little while stirring vigorously with a magnetic stirrer. After stirring for 30 minutes (If not dissolved in 30 minutes, continue stirring until dissolved. If there is a large mamako, crush it with a bamboo spatula etc.) The solution was removed from the stirrer, and an appropriate amount of the solution was transferred to a tall beaker (φ4.2 cm) for viscosity measurement. While measuring the liquid temperature with a rod-shaped thermometer, the liquid temperature was adjusted to about 20 ° C. by attaching it to ice water or hot water. At this time, it was adjusted while stirring well so that the liquid temperature would not become uneven. When the liquid temperature reached about 20 ° C., it was allowed to stand for 20 to 40 minutes in a constant temperature water bath set at about 20 ° C. After 20 to 40 minutes, the solution in the beaker was lightly stirred to confirm that the liquid temperature was 20 ° C., and the viscosity was measured using a BM viscometer (manufactured by Toki Sangyo Co., Ltd.). Viscosity (mPa · s) was calculated by setting the number of revolutions to 30 rpm and the reading value after 60 seconds as a measured value. The rotor used was changed according to the viscosity range shown below.
(Rotation speed: 30rpm)
Rotor No. 1: Viscosity in the range of 2 to 160 mPa · s. 2: Over 160 mPa · s and 1,000 mPa · s or less

[Experiment 2] Measurement of M / G ratio of sodium alginate M / G ratio of sodium alginate was measured according to a method described in a known method (Carbohydrate Research, 32 (1974), 217-225). That is, the two types of uronic acids (M: mannuronic acid, G: guluronic acid) that make up alginic acid can be classified into three types of blocks based on how they are arranged. They are a homopolymer (MM fraction) in which mannuronic acids are polymerized, a homopolymer (GG fraction) in which guluronic acids are polymerized, and a heteropolymer (MG fraction) in which mannuronic acid and guluronic acid are alternately polymerized. Since these blocks have different resistance to hydrolysis and solubility in pH, they are decomposed under the conditions such that they are cut into MM, GG, and MG fractions using the properties. Each fraction was fractionated according to a conventional method. Next, the amount of sugar in each of the obtained fractions was measured by the phenol sulfuric acid method, and the M / G ratio was calculated from the formula shown below.
M / G = (sugar amount of MM fraction + (sugar amount of MG fraction / 2)) / (sugar amount of GG fraction + (MG
Sugar amount of fraction / 2))

"Method for preparing test liquid composition"
According to the following method, it prepared by the vacuum emulsification pot. First, ion-exchanged water is added, and water-soluble ingredients such as pH adjusters (phosphates, etc.), medicinal ingredients (sodium monofluorophosphate, cetylpyridinium chloride, dipotassium glycyrrhizinate, etc.), pigments, preservatives (sodium benzoate), etc. Were mixed and dissolved by mixing and stirring. Next, a wetting agent such as sorbite liquid and glycerin was blended, and then mixed and stirred. Next, an alginate and / or xanthan gum was blended in propylene glycol taken in another container, dispersed by stirring, and then gradually added to the aqueous solution, and sufficiently mixed and stirred to dissolve. Furthermore, poorly water-soluble components such as nonionic surfactants, alcohols, medicinal components and fragrances were blended with reference to the physical properties of the raw materials. For example, polyoxyethylene hydrogenated castor oil was blended in a state where it was dissolved in advance at 60 ° C. and then dissolved in alcohol taken directly or in a separate container. In addition, poorly water-soluble medicinal components (isopropylmethylphenol, glycyrrhetinic acid, triclosan, etc.), fragrances and the like were blended in a state dissolved in alcohol taken in a separate container. All the ingredients were blended, and after mixing and stirring sufficiently, the preparation after dissolution was defined as a product immediately after production.

[Examples 1-8, Comparative Examples 1-16]
Test liquid compositions having the compositions shown in Tables 1 to 3 were prepared according to the method described above, and the usability (dischargeability, retention), pH, viscosity and Ca ion thickening effect of the product immediately after production were determined according to the method described below. evaluated. Furthermore, after filling the preparation into a transparent container (250 mL) made of PET (polyethylene terephthalate), each stored product was stored in a thermostatic bath at −5 ° C. and 50 ° C. for 1 month and left at room temperature for 1 day. The storage stability (appearance, pH, viscosity) was evaluated in accordance with the method shown in FIG.

  As the alginate, sodium alginate having different viscosities and M / G ratios of Duck Algin manufactured by Kibun Food Chemifa Co., Ltd. or Kimika Argin manufactured by Kimika Co., Ltd. was used. In addition, xanthan gum was manufactured by Kelco Monate Gum DA (viscosity: 1,300 mPa · s), and sodium monohydrogen phosphate and sodium dihydrogen phosphate as phosphates were manufactured by Taihei Chemical Industry Co., Ltd.

(1) Usability Usability is determined by filling a liquid composition (formulation) into a bottle container (container material: polyethylene terephthalate, inner plug material: polyethylene) having a capacity of 20 mL and a diameter of 1 mm. Ejectability when dispensing an appropriate amount from the container onto the finger, and retention until the preparation was applied to the tooth neck after dispensing the formulation were evaluated according to the following criteria.
(A) Ejectability (criteria)
○: An appropriate amount of the preparation can be put out on the finger by applying an appropriate force.
X: Excessive formulation appears on the finger simply by applying moderate force. Or, it is not possible to produce an appropriate amount of the drug product simply by applying an appropriate force.
(B) Retention (Criteria)
○: An appropriate amount of the preparation is dispensed on the finger and the preparation does not sag from the finger until it is applied to the tooth neck.
X: An appropriate amount of the preparation is put out on the finger, and the preparation hangs down from the finger before it is applied to the tooth neck.

(2) pH
About the sample moved to the glass container, the value after 3 minutes at 25 ° C. was measured with a pH meter (manufactured by Toa Denpa Kogyo Co., Ltd., HM-30V) and a pH electrode (manufactured by Toa Denpa Kogyo Co., Ltd., GST-5421C). Measured and evaluated according to the following criteria.
(Criteria)
○: When the pH of the product immediately after production and the product stored at 50 ° C. are in the range of 5.5 to 8.5, and the change in pH due to storage is in the range of 0 to 0.5.
Δ: When the pH of the product immediately after production and the product stored at 50 ° C. are in the range of 5.5 to 8.5, and the pH change due to storage is more than 0.5 and 1.0 or less.
X: When the pH of either the product immediately after production or the product stored at 50 ° C. is outside the range of 5.5 to 8.5, or when the pH change due to storage exceeds 1.0.

(3) Viscosity The sample was transferred to a glass screw tube (100 mL, Marum No. 8), sealed with a cap, and then left in a 25 ° C. water bath for 30 minutes. A BL type viscometer (manufactured by Toki Sangyo Co., Ltd.) was used, the rotation speed was 12 rpm, the viscosity (mPa · s) was calculated from the reading value after 2 minutes, and evaluated according to the following criteria. The rotor used was changed according to the viscosity range shown below.
(Rotation speed: 12rpm)
Rotor No. 1: Viscosity in the range of 5 to 400 mPa · s. 2: Range exceeding 400 mPa · s to 2,000 mPa · s Rotor No. 3: Over 2,000 mPa · s to 10,000 mPa · s or less (determination criteria)
(Double-circle): When the change rate of the viscosity of the 50 degreeC preservation | save goods with respect to the viscosity of the goods immediately after manufacture is the range of 0-7%.
○: When the rate of change of the viscosity of the product stored at 50 ° C. with respect to the viscosity of the product immediately after production exceeds 7% and is 15% or less.
Δ: When the rate of change in the viscosity of the product stored at 50 ° C. with respect to the viscosity of the product immediately after production is in the range of more than 15% and not more than 30%.
X: When the change rate of the viscosity of the 50 degreeC storage goods with respect to the viscosity of the goods immediately after manufacture exceeds 30%.

(4) Appearance stability For products stored at -5 ° C and 50 ° C, observe the presence or absence of appearance changes (precipitation of insoluble matter, gelation, two-phase separation, discoloration) with respect to the product immediately after manufacture, and evaluate according to the following criteria did.
(Criteria)
○: Almost no change was observed in all of insoluble matter precipitation, gelation, two-phase separation and discoloration.
Δ: A slight change was observed in one or more terms of insoluble precipitation, gelation, two-phase separation and discoloration.
X: A remarkable change was observed in one or more of precipitation, gelation, two-phase separation and discoloration of insoluble matter.

(5) Thickening effect by Ca ions 80 g of the sample was transferred to a glass beaker (100 mL), and 20 g of a 25.5 mol / L calcium chloride aqueous solution was gradually added with stirring. The beaker after addition of the aqueous calcium chloride solution was left in a 25 ° C. water bath for 30 minutes, and then the viscosity (A1) was measured using a BL type viscometer. Separately, the viscosity (A2) when ion-exchanged water 20 g was added instead of the calcium chloride aqueous solution was similarly measured, and the viscosity increase rate (times) was obtained from the following formula as an index of the thickening effect by Ca ions. The thickening effect by Ca ions was evaluated according to the following criteria. The viscosity of the sample after addition of the aqueous calcium chloride solution was 6 rpm, the viscosity after addition of ion-exchanged water was 12 rpm, and the rotor used was changed according to the viscosity range shown below.
(Rotation speed: 6rpm)
Rotor No. 1: Viscosity in the range of 10 to 800 mPa · s. 2: Range exceeding 800 mPa · s to 4,000 mPa · s Rotor no. 3: More than 4,000 mPa · s and 16,000 mPa · s or less
Range of rotor No. 4: Over 16,000 mPa · s to 100,000 mPa · s
Range (rotation speed: 12rpm)
Rotor No. 1: Viscosity in the range of 5 to 400 mPa · s. 2: Range exceeding 400 mPa · s to 2,000 mPa · s Rotor No. 3: Over 2,000 mPa · s to 10,000 mPa · s or less Range viscosity increase rate (times) = A1 / A2
(Criteria)
◎: Viscosity increase rate is 15 times or more ○: Viscosity increase rate is 7 times or more and less than 15 times △: Viscosity increase rate is 2 times or more and less than 7 times ×: Viscosity increase rate is less than 2 times

As is clear from the results shown in Table 1, (A) alginate having a 1.0% aqueous solution viscosity of 5 to 100 mPa · s and an M / G ratio of 0.5 to 2.0 is 0.4 to 2.0% by mass, (B) 0.1 to 0.6% by mass of xanthan gum, (C) the following general formula (1)
_{M n H 3-n PO 4} (1)
(However, M represents Na or K, and n is 1, 2 or 3.)
0.03-0.6% by mass of the phosphate represented by formula (D) and 45-90% by mass of water, and the mass ratio of (A) alginate / (B) xanthan gum is 1. The liquid oral composition (Examples 1 to 8) having a pH in the range of 0 to 12.0 and a pH in the range of 6.0 to 8.5 at 25 ° C. is used (ejectability, retention). In addition, excellent effects were exhibited in any of storage stability (change in appearance, pH, viscosity) and a thickening effect by Ca ions. On the other hand, as is apparent from the results shown in Tables 2 and 3, in Comparative Examples 1 to 16 that do not satisfy any of the essential requirements of the present invention, usability (dischargeability, retention), storage stability (appearance) Change, pH, viscosity) and a thickening effect due to Ca ions did not exhibit excellent effects.

[Examples 9 to 18]
Test liquid compositions for application to the cervix and gingiva of the compositions shown in Table 4 were prepared according to the above methods, and the usability (dischargeability, retention), storage stability (appearance, pH) according to the methods of the above examples. , Viscosity) and the thickening effect by Ca ions were evaluated. Moreover, according to the method shown below, the improvement effect in the retention of the medicinal component of each composition was evaluated.

The representative raw materials were from the following manufacturers. Moreover, the fragrance | flavor used either type AF shown to Tables 6-12.
・ Sodium alginate; Duck Algin made by Kibun Food Chemifa Co., Ltd. or Kimika Argin made by Kimika Co., Ltd. (those with different viscosities and M / G ratios)
Xanthan gum; monato gum DA (viscosity: 1,300 mPa · s) manufactured by Kelco
・ Sodium monohydrogen phosphate and sodium dihydrogen phosphate; manufactured by Taihei Chemical Industry Co., Ltd. ・ Polyoxyethylene hydrogenated castor oil (EO average addition mole number 60); Nikko Chemicals Co., Ltd.
Made (Product name: HCO-60)
・ Polyoxyethylene hydrogenated castor oil (EO average added mole number 100); Japan Emulsion (
(Product name: HC-100)
Polyoxyethylene (200) polyoxypropylene glycol (70); manufactured by BASF (trade name: Lutrol F-127)
・ Ethanol; Nippon Alcohol Sales Co., Ltd. ・ Sodium monofluorophosphate; Rhodia Nikka Co., Ltd. ・ Sodium fluoride; Stella Chemifa Co., Ltd. ・ Cetylpyridinium chloride; Wako Pure Chemical Industries, Ltd. ・ Isopropyl Methylphenol; Osaka Kasei Co., Ltd., glycyrrhetinic acid; Maruzen Pharmaceutical Co., Ltd., dipotassium glycyrrhizinate; Maruzen Pharmaceutical Co., Ltd.

(1) Improving effect on retention of medicinal component (fluorine compound) After recovering the fluorine compound remaining in each plate after repeating the washing operation three times according to the above method with an extraction solvent (ion-exchanged water), 20 mL Each sample solution (S1, S2) obtained by centrifugation (3,000 rpm, 10 minutes) was measured for fluorine ion concentration according to the method described below.
15 mL of each sample solution was accurately weighed into a test tube with a stopper, and 5 mL of 1 mol / L sulfuric acid was accurately added and mixed, stoppered and heated for about 5 minutes. After cooling, 3 mL of this solution was accurately weighed, capped and heated for about 5 minutes. After cooling, 9 mL of acetate buffer solution (pH 5.3) was accurately added and mixed, and transferred to a plastic container to obtain a sample solution.
The same operation was performed using a fluorine standard solution for fluorine measurement (100 ppm) (manufactured by Thermo Orion) to prepare 2.5 ppm, 0.25 ppm, 0.05 ppm, and 0.0125 ppm fluorine standard solutions.
The sample solution and the fluorine standard solution were tested by the ion electrode method. A calibration curve was prepared by plotting the concentration of the fluorine standard solution on the logarithmic axis and the measured potential reading (mV) on the equiaxed axis. Next, the fluorine (F) concentration of the sample solution was calculated using a calibration curve prepared from the measured potential reading (mV) of the sample solution.

(2) Improving effect on retention of medicinal components (anti-inflammatory agents, bactericides) Collagen coated 6-well microplate (Product No .: IWAKI, Collagen Type I-Coated MICROPLATE 6 Well With Lid) After 1 mL of saliva was added and allowed to stand for a while, the upper layer solution was collected with a micropipette and discarded. Next, 0.5 g of an evaluation sample was collected on a collagen-coated plate and spread so as to be as uniform as possible. Next, 5 mL of ion exchange water (25 ° C.) was added onto the sample, and after standing for a while, the upper layer solution was recovered with a micropipette and discarded. Next, 1 mL of artificial saliva (37 ° C.) was added onto the sample, and after standing for 30 seconds, the upper layer solution was collected with a micropipette and discarded. The operation with this artificial saliva was performed once, and the medicinal component remaining in each plate after repeating this washing operation three times was recovered with an extraction solvent (80% ethanol). That is, 5 mL of 80% ethanol was added and dispersed by pipetting, and then the total amount of this solution was recovered. This extraction and recovery operation is repeated once more, each recovered solution is made up to 20 mL with 80% ethanol, and the supernatant obtained by centrifugation (3,000 rpm, 10 minutes) is used as a medicinal component (anti-inflammatory). Sample solution (S1) for quantitative determination of the agent. Moreover, the control sample at the time of performing the same operation with ion-exchange water (37 degreeC) instead of the case where artificial saliva (37 degreeC) was used in the said operation was made into the sample solution (S2). In addition, when quantitatively analyzing cetylpyridinium chloride, a mixture of 1 mL of the obtained sample solution and 1 mL of mobile phase was used as a sample. Finally, after each sample solution (S1, S2) obtained was filtered with a membrane filter, it was analyzed by HPLC according to the method shown below, and the peak area value of the standard solution prepared separately for the concentration of the medicinal component in the sample The concentration was calculated from the relational expression.
In addition, it analyzed about three samples obtained by preparing on the same conditions. The average value of the obtained three data was calculated, and the retention improvement rate (%) of the medicinal component (fluorine compound, anti-inflammatory agent, bactericidal agent) was obtained from the following formula. Here, the improvement effect in the retention of medicinal components (fluorine compounds, anti-inflammatory agents, bactericides) was evaluated according to the following criteria.

  Here, the method for preparing artificial saliva is as follows. Add 950 mL of ion-exchanged water to a 1 L beaker, add calcium chloride, calcium chloride (dihydrate), potassium dihydrogen phosphate, magnesium chloride (hexahydrate) to the following concentrations and mix. Dissolved. Next, after adjusting pH to 7.0 with a 1 mol / L potassium hydroxide solution, ion exchange water was added to make the total volume 1L.

Artificial saliva composition:
Calcium chloride 50.0 mmol / L
Calcium chloride (dihydrate) 2.0 mmol / L
Potassium dihydrogen phosphate 1.0 mmol / L
Magnesium chloride (hexahydrate) 0.1 mmol / L
Potassium hydroxide appropriate amount (pH 7.0)
Ion exchange water remaining

Retention property improvement rate (%) = (medical component concentration of S1 / medical component concentration of S2) × 100
(Criteria)
◎: Retention property improvement rate is 250% or more ○: Retention property improvement rate is 175% or more and less than 250% △: Retention property improvement rate is 100% or more and less than 175% ×: Retention property improvement rate is less than 100% (HPLC apparatus)
Pump: JASCO Corporation (model number: PU-980)
Sample introduction part: manufactured by Kyowa Precision Co., Ltd. (model number: KSP-100X)
Detector: JASCO Corporation (model number: UV-970)
Recording device: manufactured by Stem Instruments Co., Ltd. (model number: Chromatocoder 21J
)
Column thermostat: manufactured by Senshu Scientific Co., Ltd. (model number: SSC-2100)

(1) HPLC analysis method for cetylpyridinium chloride Detector: Ultraviolet absorptiometer (measurement wavelength: 265 nm)
Column: Inertsil ODS-2 column (inner diameter 4 mm, length 150 mm) (manufactured by GL Sciences Inc.)
Column temperature: constant temperature around 30 ° C. Mobile phase: 750 mL of acetonitrile and phosphate buffer (sodium dihydrogen phosphate dihydrate;
7.8 g, phosphoric acid (3.4 mL) was mixed with 250 mL, and further dissolved by adding 1.2 g of sodium lauryl sulfate and then filtered. Flow rate: 1.0 mL / min
Sampling volume: 50 μL

(2) HPLC analysis method for isopropylmethylphenol Detector: Ultraviolet absorptiometer (measurement wavelength: 285 nm)
Column: YMC-Pack ODS-A A-303 (inner diameter 4.6 mm, length 250 mm
(Made by YMC Co., Ltd.)
Column temperature: Constant temperature around 45 ° C. Mobile phase: A mixture of 600 mL of acetonitrile, 400 mL of water and 10 mL of acetic acid, filtered, and flow rate: 0.8 mL / min
Sampling volume: 50 μL

(3) HPLC analysis method of glycyrrhetinic acid Detector: UV absorption photometer (measurement wavelength: 250 nm)
Column: YMC-Pack ODS-A A-303 (inner diameter 4.6 mm, length 250 mm
(Made by YMC Co., Ltd.)
Column temperature: Constant temperature around 45 ° C. Mobile phase: A mixture of 600 mL of acetonitrile, 400 mL of water and 10 mL of acetic acid, filtered, and flow rate: 1.1 mL / min
Sampling volume: 50 μL

(4) HPLC analysis method for dipotassium glycyrrhizinate Detector: UV absorption photometer (measurement wavelength: 250 nm)
Column: Partisil-10 ODS-3 column (inner diameter 4.6 mm, length 250 mm
) (Manufactured by GL Sciences Inc.)
Column temperature: Constant temperature around 40 ° C. Mobile phase: Phosphoric acid-triethanolamine buffer solution prepared by adding 1,000 mL of water to 5 g of triethanolamine to dissolve, and adding phosphoric acid to pH 3.0. 6
70 mL and 330 mL of acetonitrile mixed and filtered through flow rate: 1.0 mL / min
Sampling volume: 50 μL

In Examples 9 to 18 shown in Table 4, (A) alginate having a 1.0% aqueous solution viscosity of 5 to 100 mPa · s and an M / G ratio of 0.5 to 2.0 is 0.4 to 2.0 mass%, (B) 0.1-0.6 mass% xanthan gum, (C) General formula (1)
_{M n H 3-n PO 4} (1)
(However, M represents Na or K, and n is 1, 2 or 3.)
0.03 to 0.6% by mass of a phosphate represented by the formula (D) containing 45 to 90% by mass of water, and the mass ratio of (A) alginate / (B) xanthan gum is 1 The liquid composition for application to the cervix and gingiva having a pH in the range of .0 to 12.0 and a pH in the range of 6.0 to 8.5 at 25.degree. , Storage stability (appearance change, pH, viscosity) and excellent effects in any of the thickening effect by Ca ions, and further in the retention of medicinal components (fluorine compounds, anti-inflammatory agents, bactericides) The improvement effect was fully demonstrated.

[Examples 19 to 26]
Liquid dentifrices for test interdental parts having the compositions shown in Table 5 were prepared by the above-described method, and storage stability (appearance, pH, viscosity), thickening effect by Ca ions, and oral cavity of medicinal components according to the methods of the above Examples The improvement effect in internal retention was evaluated. In addition, what was described above was used for a typical raw material, and what was described in following Tables 6-12 was used for the fragrance | flavor. Here, in terms of usability, the liquid composition is filled into a bottle container (container material: polyethylene terephthalate, inner plug material: polyethylene) having a capacity of 20 mL and a discharge port having a diameter of 1 mm, and the preparation is placed on an interdental brush ( Dischargeability when dispensing an appropriate amount to Lion Corporation (DENT EX S type) and retention when brushing the interdental part after the formulation was put on the interdental brush were evaluated according to the following criteria.
(A) Ejectability (criteria)
○: An appropriate amount of the preparation can be put out on the interdental brush by applying an appropriate force.
X: An excessive amount of the preparation appears on the interdental brush only by applying an appropriate force, or an appropriate amount of the preparation cannot be output on the interdental brush only by applying an appropriate force.
(B) Retention (Criteria)
○: An appropriate amount of the preparation is put on the interdental brush, and the preparation does not sag from the interdental brush until the interdental portion is brushed.
×: Appropriate amount of the preparation was put out on the interdental brush, and the preparation dropped from the interdental brush before the interdental portion was brushed.

In Examples 19 to 26 shown in Table 5, (A) 1.0% aqueous solution has a viscosity of 5 to 100 mPa · s, and an M / G ratio of 0.5 to 2.0 alginate is 0.4 to 0.4. 2.0 mass%, (B) 0.1-0.6 mass% xanthan gum, (C) General formula (1)
_{M n H 3-n PO 4} (1)
(However, M represents Na or K, and n is 1, 2 or 3.)
0.03 to 0.6% by mass of a phosphate represented by the formula (D) containing 45 to 90% by mass of water, and the mass ratio of (A) alginate / (B) xanthan gum is 1 The interdental liquid dentifrice composition having a pH in the range of .0 to 12.0 and a pH at 25 ° C. in the range of 6.0 to 8.5 is easy to use (ejectability, retention) and storage stable. It exhibits excellent effects in any of the properties (appearance change, pH, viscosity) and the thickening effect by Ca ions, and further improves the retention of medicinal components (fluorine compounds, anti-inflammatory agents, fungicides) Fully demonstrated.

Examples 27 to 32 are shown below. In addition, the following were used for sodium alginate and xanthan gum. The fragrance | flavor used what was shown to Tables 6-12. In any of these examples, the usability (dischargeability, retention), storage stability (appearance change, pH, viscosity) and the thickening effect due to Ca ions are excellent, and further the improvement effect on the retention of medicinal components. A liquid oral composition that is sufficiently exerted was obtained.
・ Sodium alginate; Duck Algin made by Kibun Food Chemifa Co., Ltd. or Kimika Argin made by Kimika Co., Ltd. (those with different viscosities and M / G ratios)
• Xanthan gum: Monato gum DA (viscosity: 1,300 mPa · s) or Keldent (viscosity: 1,400 mPa · s) manufactured by Kelco
・ Polyoxyethylene cetyl ether (EO average addition mole number 20); Japanese emulsion (
・ Tranexamic acid manufactured by Daiichi Pharmaceutical Co., Ltd. ・ Epsilon aminocaproic acid; manufactured by Daiichi Chemicals Co., Ltd. ・ sodium ascorbate; Roche Vitamin Japan Co., Ltd. manufactured by benzalkonium chloride; Co., Ltd., Triclosan; Wako Pure Chemical Industries, Ltd., Hinokitiol; Wako Pure Chemical Industries, Ltd., Benzethonium Chloride; Wako Pure Chemical Industries, Ltd., Chlorhexidine gluconate (20%); Wako Pure Chemical Industries, Ltd. Made by Co., Ltd., dl-α-tocophenol acetate; made by Roche Vitamin Japan Co., Ltd.

[Example 27] Interdental toothpaste (A) Sodium alginate (Kimika argin, viscosity; 15 mPa · s, M / G ratio; 1.3) 0.85% by mass
(B) Xanthan gum (monate gum DA, viscosity 1,300 mPa · s) 0.30
(C) Sodium monohydrogen phosphate 0.25
(C) Sodium dihydrogen phosphate 0.05
(G) Cetylpyridinium chloride 0.05
(G) Isopropylmethylphenol 0.03
(G) Glycyrrhetinic acid 0.03
(H) Ethanol 5.0
(H) Polyoxyethylene hydrogenated castor oil (EO average added mole number 100) 3.5
Propylene glycol 3.0
Glycerin (85%) 12.0
Sorbit liquid (70%) 15.0
Fragrance C 0.55
Blue No. 1 0.001
Yellow No. 4 0.0001
Caramel color 0.002
Purified water balance
Total 100% by mass
(D) Moisture content 66%
(A) Mass ratio of alginate / (B) xanthan gum 2.8
pH 7.2

  Similar results were obtained even when sodium alginate having a viscosity of 15 mPa · s and an M / G ratio of 0.8, or a viscosity of 50 mPa · s and an M / G ratio of 0.8 was used. Similar results were obtained when keldent was used as xanthan gum. Further, similar results were obtained even when the fragrances A, B, D, E, and F were used in place of the fragrance C.

[Example 28] Liquid toothpaste (A) Sodium alginate (Duck arginine, viscosity; 30 mPa · s, M / G ratio; 0.8) 0.8% by mass
(B) Xanthan gum (monate gum DA, viscosity 1,300 mPa · s) 0.35
(C) Sodium monohydrogen phosphate 0.1
(C) Sodium dihydrogen phosphate 0.1
(E) Sodium fluoride 0.05
(F) Epsilon aminocaproic acid 0.03
(G) Triclosan 0.05
(G) Chlorhexidine gluconate (20%) 0.10
(H) Ethanol 8.0
(H) Polyoxyethylene hydrogenated castor oil (EO average added mole number 60) 1.0
Propylene glycol 2.0
Polyethylene glycol 600 3.0
Glycerin (85%) 15.0
Fragrance D 0.6
Yellow No. 4 0.001
Purified water balance
Total 100% by mass
(D) Moisture content 71%
(A) Mass ratio of alginate / (B) xanthan gum 2.3
pH 6.9

  Similar results were obtained even when sodium alginate having a viscosity of 15 mPa · s and an M / G ratio of 0.8, or a viscosity of 50 mPa · s and an M / G ratio of 1.3 was used. Similar results were obtained when keldent was used as xanthan gum. Furthermore, the same result was obtained even when the fragrances A, B, C, E, and F were used in place of the fragrance D.

[Example 29] Tooth neck and gum application agent (A) Sodium alginate (duck arginine, viscosity; 50 mPa · s, M / G ratio; 0.8) 0.8% by mass
(B) Xanthan gum (monate gum DA, viscosity 1,300 mPa · s) 0.4
(C) Sodium monohydrogen phosphate 0.1
(C) Sodium dihydrogen phosphate 0.1
(F) Tranexamic acid 0.05
(G) Benzethonium chloride 0.03
(G) Hinokitiol 0.05
(H) Ethanol 2.0
(H) Polyoxyethylene cetyl ether (EO average addition mole number 20) 0.5
Propylene glycol 3.0
Glycerin (85%) 15.0
Sorbit liquid (70%) 10.0
Allantoin 0.03
Potassium nitrate 0.02
Fragrance D 0.4
Purified water balance
Total 100% by mass
(D) Water content 73%
(A) Mass ratio of alginate / (B) xanthan gum 2.0
pH 6.8

  Similar results were obtained even when sodium alginate having a viscosity of 15 mPa · s and an M / G ratio of 1.3, or a viscosity of 50 mPa · s and an M / G ratio of 0.8 was used. Similar results were obtained when keldent was used as xanthan gum. Furthermore, the same result was obtained even when the fragrances A, B, C, E, and F were used in place of the fragrance D.

[Example 30] Liquid dentifrice (A) Sodium alginate (Kimika argin, viscosity; 10 mPa · s, M / G ratio; 1.3) 1.0% by mass
(B) Xanthan gum (Keldent, viscosity 1,400 mPa · s) 0.35
(C) Sodium dihydrogen phosphate 0.2
(F) Sodium ascorbate 0.1
(G) Acetic acid dl-α-tocophenol 0.03
(G) Triclosan 0.03
(G) Benzalkonium chloride 0.05
(H) Ethanol 4.0
(H) Polyoxyethylene (200)
Polyoxypropylene glycol (70) 1.0
Propylene glycol 2.0
Glycerin (85%) 20.0
Sorbit liquid (70%) 10.0
Sodium bicarbonate 0.1
Fragrance E 0.5
Blue No. 1 0.001
Purified water balance
Total 100% by mass
(D) Moisture content 67%
(A) Mass ratio of alginate / (B) xanthan gum 2.9
pH 7.5

  Similar results were obtained even when sodium alginate having a viscosity of 30 mPa · s and an M / G ratio of 0.8, or a viscosity of 50 mPa · s and an M / G ratio of 0.8 was used. Similar results were obtained even when monato gum DA was used as xanthan gum. Furthermore, the same result was obtained even when the fragrances A, B, C, D, and F were used in place of the fragrance E.

[Example 31] Liquid toothpaste (A) Sodium alginate (Duck arginine, viscosity; 80 mPa · s, M / G ratio; 0.8) 1.2% by mass
(B) Xanthan gum (monate gum DA, viscosity 1,300 mPa · s) 0.4
(C) Sodium monohydrogen phosphate 0.2
(C) Sodium dihydrogen phosphate 0.1
(F) Tranexamic acid 0.05
(G) Chlorhexidine hydrochloride 0.02
(H) Ethanol 2.0
(H) Polyoxyethylene hydrogenated castor oil (EO average added mole number 60) 0.5
(H) Polyoxyethylene hydrogenated castor oil (EO average added mole number 100) 2.0
Silicic anhydride 5.0
Propylene glycol 3.0
Glycerin (85%) 12.0
Sorbit liquid (70%) 15.0
Xylitol 5.0
Fragrance F 0.5
Ascorbic acid-2-phosphate sodium salt 0.1
Stannous fluoride 0.05
Yellow No. 4 0.001
Caramel color 0.003
Purified water balance
Total 100% by mass
(D) Water content 59%
(A) Mass ratio of alginate / (B) xanthan gum 3.0
pH 7.0

  Similar results were obtained when sodium alginate having a viscosity of 30 mPa · s and an M / G ratio of 0.8, or a viscosity of 50 mPa · s and an M / G ratio of 1.3 was used. . Similar results were obtained when keldent was used as xanthan gum. Further, similar results were obtained even when the fragrances A, B, C, D and E were used in place of the fragrance F.

[Example 32] Liquid toothpaste (A) Sodium alginate (Kimika argin, viscosity; 15 mPa · s, M / G ratio; 1.3) 0.9% by mass
(B) Xanthan gum (monate gum DA, viscosity 1,300 mPa · s) 0.3
(C) Sodium monohydrogen phosphate 0.23
(C) Sodium dihydrogen phosphate 0.04
(E) Sodium monofluorophosphate 0.3
(G) Isopropylmethylphenol 0.03
(G) Cetylpyridinium chloride 0.05
(G) Glycyrrhetinic acid 0.03
(H) Ethanol 6.0
(H) Polyoxyethylene hydrogenated castor oil (EO average added mole number 100) 3.0
Propylene glycol 3.0
Glycerin (85%) 10.0
Sorbit liquid (70%) 15.0
Fragrance A 0.6
Blue No. 1 0.001
Purified water balance
Total 100% by mass
(D) Moisture content 67%
(A) Mass ratio of alginate / (B) xanthan gum 3.0
pH 7.2

  Similar results are obtained even when sodium alginate having a viscosity of 15 mPa · s and an M / G ratio of 0.8, or a viscosity of 30 mPa · s and an M / G ratio of 0.8 or 1.3 is used. was gotten. Similar results were obtained when keldent was used as xanthan gum. Furthermore, the same result was obtained even when the fragrances B, C, D, E, and F were used in place of the fragrance A.

Claims (5)

(A) The viscosity of a 1.0 mass% aqueous solution at 20 ° C. is 5 to 100 mPa · s, and the content ratio (M / G ratio) of D-mannuronic acid and L-guluronic acid in the molecule is 0.5 to 2 0.0 (mass ratio) of alginate 0.4 to 2.0% by mass,
(B) 0.1 to 0.6% by mass of xanthan gum,
(C) The following general formula (1)
_{M n H 3-n PO 4} (1)
(However, M represents Na or K, and n is 1, 2 or 3.)
0.03-0.6% by mass of a phosphate represented by
(D) 45-90 mass% of moisture
And the mass ratio of (A) alginate / (B) xanthan gum is in the range of 1.0 to 12.0, and the pH at 25 ° C is in the range of 6.0 to 8.5. Liquid oral composition.   The liquid oral composition according to claim 1, further comprising (E) at least one fluorine compound selected from sodium fluoride and sodium monofluorophosphate.   The liquid oral composition according to claim 1 or 2, further comprising (F) at least one anti-inflammatory agent selected from tranexamic acid, epsilon aminocaproic acid, glycyrrhizinate, ascorbic acid or a salt thereof. object.   Furthermore, (G) an anti-inflammatory agent selected from glycyrrhetinic acid and dl-α-tocophenol acetate and / or isopropylmethylphenol, triclosan, hinokitiol, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, chlorhexidine gluconate, chlorhexidine hydrochloride The liquid composition for oral cavity according to any one of claims 1 to 3, further comprising (H) a nonionic surfactant and / or ethanol. The liquid oral composition according to any one of claims 1 to 4, wherein the composition is an interdental product applied by an interdental brush, or a cervical or gingival application product applied by a finger. .