JP5570777B2 - Oral composition - Google Patents

Description

  The present invention relates to an improvement in flavor of an oral composition containing a high concentration of polyhydric alcohol. More specifically, the present invention relates to an oral composition whose flavor is improved by blending a specific amount of cyclodextrin or magnesium sulfate with a composition having a low water content and a high concentration of polyhydric alcohol. Furthermore, when an ionic surfactant is mix | blended, it is related with the composition for oral cavity characterized by the effect that the raw material odor derived from an ionic surfactant is reduced significantly.

  Attempts have been made to suppress oral bacteria that cause periodontal disease and caries by using a composition for oral cavity containing lactic acid bacteria and to improve the oral hygiene environment. This technique is known to require the lactic acid bacteria to remain in a viable state in the oral composition. Since lactic acid bacteria are known to tend to die over time in the presence of water, it is necessary that the oral composition containing lactic acid bacteria has a formulation that does not contain water as much as possible.

  On the other hand, vitamin C and polyphenols are known to have anti-inflammatory and bactericidal effects. However, it is known that these oxidative-sensitive substances also tend to decrease over time in the presence of water. Therefore, it is necessary to have a formulation that does not contain water as much as possible.

  In order to avoid the inclusion of water in the oral composition as much as possible, it is common practice to blend a dihydric alcohol or a polyhydric alcohol mainly composed of a trihydric alcohol instead of water. However, in this case, when a large amount of dihydric alcohol or trihydric alcohol is blended, there is a problem that the palatability of the flavor of the oral composition is extremely deteriorated.

  In order to solve this problem, for example, a technique for blending L-aspartyl-L-phenylalanine lower alkyl ester (Patent Document 1), a technique for blending sodium bicarbonate (Patent Document 2), and the like have been proposed. However, even with these techniques, a sufficient effect cannot be obtained yet, and development of an oral composition having a further improved flavor is desired.

JP-A-56-8310 JP 2002-302429 A

  The present invention relates to an oral composition having a low content of water and containing a high concentration of dihydric alcohol or trihydric alcohol, wherein the flavor derived from polyhydric alcohol is improved, and further an ionic surfactant It aims at providing the composition for oral cavity which reduced the raw material odor.

  As a result of intensive studies to solve the above problems, the present inventors have surprisingly found that the flavor of the oral composition can be improved by blending a specific amount of cyclodextrin, and the present invention has been completed. It was.

That is, the present invention includes the following aspects.
Item 1.2 An oral composition containing 40% by mass or more of at least one polyhydric alcohol selected from trihydric alcohols and trihydric alcohols, wherein cyclodextrin is 0% relative to the total amount of the polyhydric alcohols. An oral composition characterized by containing 0.03 to 0.3 times the amount.
Item 2. Furthermore, magnesium sulfate is mix | blended, The composition for oral cavity of claim | item 1 characterized by the above-mentioned.
Item 3. Item 3. The oral composition according to any one of Items 1 and 2, wherein the polyhydric alcohol is one or more selected from propylene glycol, 1,3-butylene glycol, polyethylene glycol, and glycerin.
Item 4. Item 4. The oral composition according to any one of Items 1 to 3, wherein the cyclodextrin is β-cyclodextrin.
Item 5. Furthermore, an ionic surfactant is mix | blended, The composition for oral cavity in any one of claim | item 1-4 characterized by the above-mentioned.
Item 6. Item 6. The oral cavity according to any one of Items 1 to 5, wherein the ionic surfactant is at least one selected from a sulfate ester surfactant, a sulfosuccinic acid surfactant, and an amino acid surfactant. Composition.
Item 7. Furthermore, 15 mass% or more of 1 or more types chosen from an anhydrous silicic acid, calcium phosphate, and calcium carbonate is mix | blended, The composition for oral cavity in any one of claim | item 1 -6 characterized by the above-mentioned.
Furthermore, this invention provides the composition for oral cavity in any one of claim | item 1 -7 characterized by not mix | blending water as a raw material.
Moreover, this invention provides the composition for oral cavity in any one of claim | item 1 -7 characterized by mix | blending 8-50 mass% of sugar alcohol further.

  In the composition for oral cavity containing 40% by mass or more of the divalent and trivalent polyhydric alcohols of the present invention, the flavor derived from the polyhydric alcohol is effectively improved by blending a specific amount of cyclodextrin. Further, this effect is further enhanced when magnesium sulfate is blended. In addition, when an anionic surfactant or an amphoteric surfactant is added, the raw material odor derived from the active agent can be effectively improved, and the appearance and properties of the oral composition can be improved. Become.

The result of having evaluated bitterness about Example 1 and Comparative Example 1 is shown. The result of having performed freshness evaluation about Example 1 and Comparative Example 1 is shown. The result of having evaluated activator odor about Example 1 and Comparative Example 1 is shown. The result of having evaluated palatability about Example 1 and Comparative Example 1 is shown.

  Hereinafter, the present invention will be described in more detail.

  The dihydric alcohol and trihydric alcohol used in the present invention are not particularly limited as long as they can be used in the oral composition. For example, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol Glycerin and the like. Among these, the effect with respect to propylene glycol, 1, 3- butylene glycol, polyethylene glycol, and glycerol is high. A dihydric alcohol and a trihydric alcohol can be mix | blended individually or in combination of 2 or more types, The total compounding quantity is 40 mass% or more, 40-65 mass% is more preferable, 50-65 mass. % Is the most effective and preferred.

  The cyclodextrin used for this invention will not be specifically limited if it can be used for a composition for oral cavity. Examples include α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin and the like, and β-cyclodextrin is particularly preferable. Cyclodextrin can be blended alone or in appropriate combination of two or more, and is preferably 0.03 to 0.3 times the total blended amount of dihydric alcohol and trihydric alcohol, 0.05 to 0.2 times the amount is more preferable. If the amount is less than 0.03 times, there is a risk that the taste and odor of the oral composition will not be improved. Although it will not specifically limit as a compounding quantity if it matches said compounding ratio, it is 1-10 mass%, Preferably it is 2-6 mass%.

  Magnesium sulfate used in the present invention is not particularly limited as long as it can be used in pharmaceuticals, foods, and cosmetics, and it does not matter whether it is an anhydride or a hydrate. The blending amount may be 7% by mass or less, and preferably 5% by mass or less. When magnesium sulfate is blended, the effect of cyclodextrin can be enhanced, so that the blending amount of cyclodextrin can be reduced. The total amount of cyclodextrin and magnesium sulfate is preferably 0.03 to 0.3 times the total amount of dihydric alcohol and trihydric alcohol, and 0.05 to 0.2 times. The amount is more preferred.

  The ionic surfactant used in the present invention means an anionic surfactant, a cationic surfactant, or an amphoteric surfactant, and is not particularly limited as long as it can be used for an oral composition. Among these, the effect with respect to an anionic surfactant is high, and the effect with respect to a sulfate ester type surfactant, a sulfosuccinic acid type surfactant, and an amino acid type surfactant is remarkable. Specifically, as sulfate-based surfactants, alkyl sulfates such as sodium lauryl sulfate and polyoxyethylene alkyl ether sulfates such as polyoxyethylene (1) sodium lauryl ether sulfate; sulfosuccinic acid-based surfactants Examples of the surfactant include sodium lauryl sulfosuccinate; examples of the amino acid surfactant include sodium lauryl sarcosine and sodium lauryl glutamate. Among these, the effect with respect to a sulfate ester type surfactant is high. These ionic surfactants can be blended alone or in appropriate combination of two or more.

  The silicic anhydride, calcium phosphate, and calcium carbonate used in the present invention are not particularly limited as long as they can be used for pharmaceuticals, foods, and cosmetics. These can be blended alone or in appropriate combination of two or more. Although it does not prescribe | regulate especially as a compounding quantity, it is preferable that these total compounding quantities are 15 mass% or more, 15-40 mass% is further more preferable, and 15-30 mass% is the most preferable.

  The sugar alcohol used in the present invention is not particularly limited as long as it can be used in pharmaceuticals, foods, and cosmetics. Examples include erythritol, threitol, ribitol, arabinitol, xylitol, allitol, sorbitol, mannitol, iditol, galactitol, taritol, maltitol, lactitol, etc. Among these, erythritol, sorbitol, xylitol, mannitol are preferable, Most preferred are xylitol, erythritol, and sorbitol. These can be blended alone or in appropriate combination of two or more. Although it does not prescribe | regulate especially as a compounding quantity, it is preferable that these total compounding quantities are 8-50 mass% or more, 8-35 mass% is further more preferable, and 8-30 mass% is the most preferable.

  The oral composition of the present invention has a water content of 0 to 10% by mass. The smaller the amount of water contained in the composition, the better the effect, and preferably 0 to 8% by mass, more preferably 0 to 5% by mass. These waters include water mixed into the composition by blending a raw material containing water as essential, such as glycerin, in addition to water blended as a raw material. Most preferred is an oral composition that does not contain water as a raw material. In this case, although depending on the raw material to be blended, in many cases, about 8% by mass, usually about 5% by mass of water is contained in the composition. The moisture content can be measured by a volumetric titration method described in 2.48 moisture measurement method (Karl Fischer method) of the 15th revision Japanese Pharmacopoeia.

  In addition to the above components, other components can be added to the oral composition of the present invention. For example, nonionic surfactants, sweeteners, binders, flavoring agents, medicinal agents, pH adjusters, colorants, ethanol, and the like can be appropriately blended within a range that does not impair the effects of the present invention.

  Nonionic surfactants include, for example, polyoxyethylene hydrogenated castor oil, sucrose fatty acid esters, fatty acid alkanolamides, sorbitan fatty acid esters, fatty acid monoglycerides, polyoxyethylene alkyl ethers, polyoxyethylene alkyl phenyl ethers, and the like. . These nonionic surfactants can be blended alone or in appropriate combination of two or more.

  Sweetening agents include, for example, saccharin, saccharin sodium, acesulfame potassium, stevia extract, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perilartin, thaumatin, asparatylphenylalanyl methyl ester, xylitol, palatinose, palatinit, erythritol, multi Tall, methoxycinnamic aldehyde, xylit, sucralose, etc. can be blended. These sweeteners can be blended alone or in appropriate combination of two or more, and can be blended in an amount of usually 0.01 to 1% by mass based on the total amount of the oral composition.

  Examples of the binder include cellulose derivatives such as hydroxyethyl cellulose and hydroxypropyl cellulose, carboxymethyl cellulose and salts thereof, alkali metal alginates such as carrageenan and sodium alginate, gums such as xanthan gum, tragacanth gum, caraya gum, gum arabic and gellan gum, Synthetic binders such as polyvinyl alcohol and sodium polyacrylate can be blended. These can be blended alone or in combination of two or more, and can be blended in an amount of 0.001 to 30% by mass based on the total amount of the oral composition.

  As a flavoring agent, menthol, carboxylic acid, anethole, eugenol, methyl salicylate, limonene, osimene, n-decyl alcohol, citronell, α-terpineol, methyl acetate, citronenyl acetate, methyl eugenol, cineol, linalool, ethyl Examples include perfume such as linalool, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, perilla oil, winter green oil, clove oil, eucalyptus oil, and pimento oil. These flavoring agents can be blended singly or in combination of two or more, and blended at a ratio of about 0.01 to 5% by mass, preferably about 0.05 to 1% by mass, based on the total amount of the oral composition. can do.

  Medicinal agents include, for example, cationic fungicides such as cetylpyridinium chloride, benzalkonium chloride, and benzethonium chloride; nonionic fungicides such as triclosan and isopropylmethylphenol; dextranase, amylase, protease, mutanase, lysozyme, lysis Enzymes such as enzymes (Litec Enzymes); anti-inflammatory agents such as tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxyl allantoin, dihydrocholesterol, glycyrrhizin salts, glycyrrhetinic acid; thiamines, riboflavins, pyridoxines, vitamin B12, folic acid, Vitamins such as niacin, biotin, pantothenic acid, vitamin C, vitamin A, vitamin D, vitamin E, vitamin K; others, glycerophosphate, black Examples include natural extract ingredients such as phyll, sodium chloride, caropeptide dodecyl diaminoethyl glycine, fluorine, sodium fluoride, sodium monofluorophosphate, and hinokithiol, duckweed, green gon extract, chamomile, tincture. Two or more kinds can be combined and blended.

  The oral composition of the present invention can be made into a normal dosage form such as a toothpaste, a liquid dentifrice, a mouthwash, a coating agent, a gel agent, an ointment, a pasta agent, etc. It can also be used. Of these, toothpastes, gels and coating agents are preferred, and toothpastes are most preferred.

  Hereinafter, the present invention will be specifically described, but the present invention is not limited to the following examples. In addition, the compounding quantity in each example shows the mass% unless there is special prescription | regulation.

Example 1
Evaluation of flavor improvement effect / activator odor reduction effect Absolute evaluation was performed on 10 specialist panels to evaluate the flavor improvement effect and activator odor reduction effect. The toothpastes shown in Example 1 and Comparative Example 1 were prepared according to a conventional method and then filled into a laminate tube having a diameter of about 2 cm. The evaluator took about 0.5 g of each toothpaste in a specified toothbrush immediately before the evaluation, and brushed for 1 minute according to a conventional method. Thereafter, the mouth was rinsed with 30 ml of water, and the feeling of use during and after dentifrice was evaluated on a 5-point scale for each evaluation item and scored. The evaluation items were bitterness (weak 5 to strong 1), freshness (strong 5 to weak), activator odor (weak 5 to weak 1) palatability (like 5 to dislike 1). As for the evaluation results, the distribution was confirmed by a histogram, the average value of each was calculated, and both were compared from the results. The results are shown in Table 1 and FIGS.

  As shown in Table 1 and FIGS. 1 to 4, it was found that by adding β-cyclodextrin, the bitterness can be significantly suppressed without reducing the refreshingness, and the activator odor can be remarkably improved. As a result, it was found that the palatability was significantly improved and the technology was significant.

Using the same method as in Example 1, the feeling of use, appearance, and properties in Examples 1 to 6 and Comparative Examples 1 and 2 were evaluated in 5 stages and scored. The evaluation items for the feeling of use were a flavor improving effect (1 to 5) and a raw material odor reducing effect (5 to 1), and the appearance and properties were judged visually. (Good 5-Bad 1). For the evaluation results, an average value was calculated for each evaluation item and classified into two stages according to the following.
○ The average value of evaluation points is 3.5 or more
X Table 2 shows the results of evaluation with an average value of evaluation points of less than 3.5.

  As shown in Table 2, even if 0.006 times the amount of β-cyclodextrin is added relative to the total amount of divalent and trivalent polyhydric alcohols, the flavor improving effect and the raw material odor reducing effect are obtained. However, it was found that when 0.03 times the amount of β-cyclodextrin was added, a flavor improving effect and a raw material odor reducing effect were obtained. Further, it was found that when 0.32 times the amount of β-cyclodextrin was blended with respect to the total blending amount of the divalent and trivalent polyhydric alcohols, the appearance and properties of the composition part deteriorated.

Formulation Example 1
A gel was prepared according to a conventional method.
Ingredients Amount
Concentrated glycerin 30
1,3-butylene glycol 50
Hydrogenated starch degradation product 5
Cyclodextrin mixture 4
(Α-: 60%, β-: 30%, γ-: 10%)
Xanthan gum 0.2
Methyl benzoate 0.1
Sorbitol remaining
Total 100.0

Formulation example 2
A gel was prepared according to a conventional method.
Ingredients Amount
Concentrated glycerin 25
1,3-butylene glycol 15
Erythritol 15
Mannitol 10
β-cyclodextrin 8
Sodium polyacrylate 2
Sodium benzoate 0.5
Palm oil fatty acid amidopropyl betaine 0.5
Pullulan 0.2
Fragrance 0.2
Sorbitol remaining
Total 100.0

Formulation Example 3
A gel was prepared according to a conventional method.
Ingredients Amount
Xylitol 15
Reduced starch saccharified product 15
Concentrated glycerin 15
1,3-butylene glycol 15
Polyethylene glycol 400 10
α-Cyclodextrin 6
β-cyclodextrin 6
Sodium polyacrylate 0.9
Sodium alginate 0.1
Sorbitol remaining
Total 100.0

Formulation Example 4
A gel was prepared according to a conventional method.
Ingredients Amount
Reduced starch saccharified product 25
Concentrated glycerin 25
1,3-butylene glycol 20
Polyethylene glycol 400 15
β-cyclodextrin 2
Magnesium sulfate 1
Sodium polyacrylate 0.9
Sodium alginate 0.2
Sorbitol remaining
Total 100.0

Formulation Example 5
An ointment was prepared according to a conventional method.
Ingredients Amount
Reduced starch saccharified product 25
Concentrated glycerin 30
Propylene glycol 10
β-cyclodextrin 8
Magnesium sulfate 6
Sodium polyacrylate 1
Polyoxyethylene hydrogenated castor oil (EO60) 0.5
Fragrance 0.1
Sorbitol remaining
Total 100.0

Formulation Example 6
A pasta preparation was prepared according to a conventional method.
Ingredients Amount
Concentrated glycerin 20
1,3-butylene glycol 20
Glyceryl monostearate 15
Hydrogenated starch degradation product 15
Cyclodextrin mixture 6
(Α-: 60%, β-: 30%, γ-: 10%)
Magnesium sulfate 6
Hydroxyethyl cellulose 5
Sorbitol remaining
Total 100.0

Claims (6)

In an oral composition containing 40% by mass or more of one or more polyhydric alcohols selected from dihydric alcohols and trihydric alcohols, cyclodextrin is used in an amount of 0.03 to the total compounding amount of the polyhydric alcohols. The composition for oral cavity characterized by mix | blending 0.3 time amount and also mix | blending magnesium sulfate . The composition for oral cavity according to claim 1 , wherein the polyhydric alcohol is one or more selected from propylene glycol, 1,3-butylene glycol, polyethylene glycol, and glycerin. The composition for oral cavity according to any one of claims 1 and 2, wherein the cyclodextrin is β-cyclodextrin. Furthermore, an ionic surfactant is mix | blended, The composition for oral cavity of any one of Claims 1-3 characterized by the above-mentioned. 5. The ionic surfactant according to any one of claims 1 to 4, wherein the ionic surfactant is at least one selected from a sulfate ester surfactant, a sulfosuccinic acid surfactant, and an amino acid surfactant. The composition for oral cavity of description. Furthermore, 15 mass% or more of 1 or more types chosen from a silicic acid anhydride, calcium phosphate, and calcium carbonate is mix | blended, The composition for oral cavity of any one of Claims 1-5 characterized by the above-mentioned.

Images