JP6804973B2 - Toothpaste composition - Google Patents
Toothpaste composition Download PDFInfo
- Publication number
- JP6804973B2 JP6804973B2 JP2016254278A JP2016254278A JP6804973B2 JP 6804973 B2 JP6804973 B2 JP 6804973B2 JP 2016254278 A JP2016254278 A JP 2016254278A JP 2016254278 A JP2016254278 A JP 2016254278A JP 6804973 B2 JP6804973 B2 JP 6804973B2
- Authority
- JP
- Japan
- Prior art keywords
- polyoxyethylene
- sulfosuccinate
- disodium
- carbon atoms
- monoalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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- 239000000203 mixture Substances 0.000 title claims description 75
- 239000000606 toothpaste Substances 0.000 title claims description 53
- 229940034610 toothpaste Drugs 0.000 title claims description 53
- -1 polyoxyethylene Polymers 0.000 claims description 104
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 72
- 125000004432 carbon atom Chemical group C* 0.000 claims description 38
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 claims description 37
- 239000004094 surface-active agent Substances 0.000 claims description 36
- JMGZBMRVDHKMKB-UHFFFAOYSA-L disodium;2-sulfobutanedioate Chemical compound [Na+].[Na+].OS(=O)(=O)C(C([O-])=O)CC([O-])=O JMGZBMRVDHKMKB-UHFFFAOYSA-L 0.000 claims description 32
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 24
- 239000000194 fatty acid Substances 0.000 claims description 24
- 229930195729 fatty acid Natural products 0.000 claims description 24
- 229920000858 Cyclodextrin Polymers 0.000 claims description 23
- 239000007787 solid Substances 0.000 claims description 21
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 15
- 150000004665 fatty acids Chemical class 0.000 claims description 14
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 9
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- QAILABCGXUUVHT-UHFFFAOYSA-N 4-dodecoxy-4-oxo-3-sulfobutanoic acid Chemical compound CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC(O)=O QAILABCGXUUVHT-UHFFFAOYSA-N 0.000 claims description 5
- 239000001116 FEMA 4028 Substances 0.000 claims description 4
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 4
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 4
- 229960004853 betadex Drugs 0.000 claims description 4
- LTVJJSFLSYSCEF-UHFFFAOYSA-L disodium;4-dodecoxy-4-oxo-3-sulfonatobutanoate Chemical compound [Na+].[Na+].CCCCCCCCCCCCOC(=O)C(S([O-])(=O)=O)CC([O-])=O LTVJJSFLSYSCEF-UHFFFAOYSA-L 0.000 claims description 4
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims description 4
- 229940080345 gamma-cyclodextrin Drugs 0.000 claims description 4
- 229920006395 saturated elastomer Polymers 0.000 claims description 4
- 125000004417 unsaturated alkyl group Chemical group 0.000 claims description 4
- QZXSMBBFBXPQHI-UHFFFAOYSA-N N-(dodecanoyl)ethanolamine Chemical compound CCCCCCCCCCCC(=O)NCCO QZXSMBBFBXPQHI-UHFFFAOYSA-N 0.000 claims description 3
- SMZYPAUYZQXCOP-UHFFFAOYSA-N S(=O)(=O)(O)C(C(=O)O)CC(=O)O.N(CCO)CCO Chemical compound S(=O)(=O)(O)C(C(=O)O)CC(=O)O.N(CCO)CCO SMZYPAUYZQXCOP-UHFFFAOYSA-N 0.000 claims description 3
- VKTIOFKTYOYYOD-UHFFFAOYSA-L [Mg+2].S(=O)(=O)(O)C(C(=O)OCCCCCCCCCCCC)CC(=O)[O-].C(CCCCCCCCCCC)OC(C(CC(=O)[O-])S(=O)(=O)O)=O Chemical compound [Mg+2].S(=O)(=O)(O)C(C(=O)OCCCCCCCCCCCC)CC(=O)[O-].C(CCCCCCCCCCC)OC(C(CC(=O)[O-])S(=O)(=O)O)=O VKTIOFKTYOYYOD-UHFFFAOYSA-L 0.000 claims description 3
- MJJJJEUEZVGFLW-UHFFFAOYSA-N 2-dodecyl-2-sulfobutanedioic acid Chemical compound CCCCCCCCCCCCC(S(O)(=O)=O)(C(O)=O)CC(O)=O MJJJJEUEZVGFLW-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 238000005187 foaming Methods 0.000 description 24
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 14
- 239000003921 oil Substances 0.000 description 11
- 235000019198 oils Nutrition 0.000 description 11
- 230000001680 brushing effect Effects 0.000 description 10
- 239000006260 foam Substances 0.000 description 8
- 239000000377 silicon dioxide Substances 0.000 description 7
- 239000011230 binding agent Substances 0.000 description 6
- 238000011156 evaluation Methods 0.000 description 6
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 235000002639 sodium chloride Nutrition 0.000 description 6
- 239000000645 desinfectant Substances 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- 238000007792 addition Methods 0.000 description 4
- 150000008051 alkyl sulfates Chemical class 0.000 description 4
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 235000003599 food sweetener Nutrition 0.000 description 4
- 239000003205 fragrance Substances 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- 239000003765 sweetening agent Substances 0.000 description 4
- 239000000080 wetting agent Substances 0.000 description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229960003237 betaine Drugs 0.000 description 3
- 239000001506 calcium phosphate Substances 0.000 description 3
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 3
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000000551 dentifrice Substances 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- ZYEMGPIYFIJGTP-UHFFFAOYSA-N O-methyleugenol Chemical compound COC1=CC=C(CC=C)C=C1OC ZYEMGPIYFIJGTP-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- IGODOXYLBBXFDW-UHFFFAOYSA-N alpha-Terpinyl acetate Chemical compound CC(=O)OC(C)(C)C1CCC(C)=CC1 IGODOXYLBBXFDW-UHFFFAOYSA-N 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 2
- 235000019700 dicalcium phosphate Nutrition 0.000 description 2
- 150000004683 dihydrates Chemical class 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
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- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- 235000019477 peppermint oil Nutrition 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- SLBXZQMMERXQAL-UHFFFAOYSA-M sodium;1-dodecoxy-4-hydroxy-1,4-dioxobutane-2-sulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O SLBXZQMMERXQAL-UHFFFAOYSA-M 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
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Description
本発明は、歯磨き組成物等に関する。 The present invention relates to toothpaste compositions and the like.
スルホコハク酸系界面活性剤は、歯牙表面へのステイン形成抑制効果を奏し得ることが知られており、主に液体口腔用組成物に配合されている（例えば特許文献１）。 It is known that a sulfosuccinic acid-based surfactant can exert an effect of suppressing stain formation on the tooth surface, and is mainly blended in a liquid oral composition (for example, Patent Document 1).
一般的に歯磨きを３分間行うと、歯の着色汚れ（ステイン）はある程度は除去できるといわれている。しかし一部は残ってしまい、これが蓄積すると見た目にも顕著なステインとなるため、定期的に（例えば週に１度など）、３分以上の時間をかけて歯磨きを行い、蓄積したステインをしっかり除去する必要がある。 Generally, it is said that coloring stains (stains) on teeth can be removed to some extent by brushing teeth for 3 minutes. However, some of it remains, and when it accumulates, it becomes a noticeable stain, so brush your teeth regularly (for example, once a week) for 3 minutes or more to firmly remove the accumulated stain. Need to be removed.
本発明者らは、ステイン形成抑制効果を有するスルホコハク酸系界面活性剤を歯磨き組成物に配合することを試みた。スルホコハク酸系界面活性剤は硫酸エステル系界面活性剤等に比べ起泡力が低いことが知られており、このため起泡力向上だけでなく泡の安定性を考慮した処方設計を行なうことが望ましい。この点を考慮し、約３分間の歯磨き時間の間十分な泡立ちを得られるように設計したしたスルホコハク酸系界面活性剤を含有する歯磨き組成物（特にペースト状の歯磨き組成物）を調製することが好ましい。しかし、このように調製した歯磨き組成物を用いて３分を超えるブラッシングを行うと、泡量が多くなりすぎてブラッシングがしにくくなったり、口から泡があふれる場合があること、並びに、口中の泡を吐き出してからブラッシングを継続使用としても泡立ちが弱いためブラッシングしやすい十分な泡量を確保することができないこと、を本発明者らは見出した。 The present inventors have attempted to incorporate a sulfosuccinic acid-based surfactant having a stain-forming inhibitory effect into a dentifrice composition. It is known that sulfosuccinic acid-based surfactants have lower foaming power than sulfate ester-based surfactants, etc. Therefore, it is necessary to design a formulation that not only improves foaming power but also considers foam stability. desirable. In consideration of this point, prepare a toothpaste composition (particularly a paste-like toothpaste composition) containing a sulfosuccinic acid-based surfactant designed to obtain sufficient foaming for a toothpaste time of about 3 minutes. Is preferable. However, if the toothpaste composition prepared in this way is used for brushing for more than 3 minutes, the amount of foam may become too large to make brushing difficult, or the foam may overflow from the mouth, and the foam in the mouth may overflow. The present inventors have found that even if brushing is continued after spitting out foam, the foaming is weak and it is not possible to secure a sufficient amount of foam that is easy to brush.
また、ステインの除去は人目に付きやすい前歯を主として行なわれるが、前歯を磨く場合、唇を大きく空けておく必要があるため、泡立ちが良すぎると口元から泡が漏れ出しやすく、継続して磨きにくいという課題もある。 In addition, stains are mainly removed from the front teeth, which are easily noticeable, but when brushing the front teeth, it is necessary to leave the lips wide open, so if the foam is too good, bubbles will easily leak from the mouth, and continuous brushing will be performed. There is also the problem that it is difficult.
そこで、（特にある程度の時間（例えば３分間）以上ブラッシングを行った場合であっても、）泡立ちが抑制される、スルホコハク酸系界面活性剤含有歯磨き組成物を調製することが考えられる。しかし、泡立ちを低減するためにスルホコハク酸系界面活性剤配合量を少なくすると、ステイン形成抑制効果も不十分になるおそれがある。また、泡立ちが必要以上に低減されると、今度は使用者が満足な使用感を得られないおそれもある。 Therefore, it is conceivable to prepare a sulfosuccinic acid-based surfactant-containing toothpaste composition that suppresses foaming (even when brushing is performed for a certain period of time (for example, 3 minutes) or more). However, if the amount of the sulfosuccinic acid-based surfactant compounded is reduced in order to reduce foaming, the effect of suppressing stain formation may be insufficient. In addition, if foaming is reduced more than necessary, the user may not be able to obtain a satisfactory usability.
そこで、本発明は、スルホコハク酸系界面活性剤を含有しつつも使用時の泡立ちが適度な固形状の歯磨き組成物を提供することを課題とする。 Therefore, an object of the present invention is to provide a solid toothpaste composition containing a sulfosuccinic acid-based surfactant and having an appropriate foaming during use.
本発明者らは、シクロデキストリンがスルホコハク酸系界面活性剤含有歯磨き組成物の泡立ちを適度なもの（泡立ち過ぎず、かつ泡立ちが弱すぎることもない）とし得ることを見出し、さらに改良を重ねて本発明を完成させるに至った。 The present inventors have found that cyclodextrin can make the foaming of a sulfosuccinic acid-based surfactant-containing toothpaste composition appropriate (not too foaming and neither too weak foaming), and further improvements have been made. The present invention has been completed.
本発明は例えば以下の項に記載の主題を包含する。
項１．
スルホコハク酸系界面活性剤及びシクロデキストリンを含有する固形状の歯磨き組成物。
項２．
固形状の歯磨き組成物が、ペースト状、ジェル状、又は粉状の歯磨き組成物である、項１に記載の固形状の歯磨き組成物。
項３．
シクロデキストリンが、β−シクロデキストリン及びγ−シクロデキストリンからなる群より選択される少なくとも１種である、項１又は２に記載の固形状の歯磨き組成物。
項４．
スルホコハク酸系界面活性剤が、有するアルキル基が炭素数８〜１８の飽和又は不飽和のアルキル基、エチレンオキサイドの平均付加モル数が０〜７、であるモノアルキルスルホコハク酸／ポリオキシエチレンモノアルキルスルホコハク酸およびその塩からなる群より選択される少なくとも１種である、項１〜３のいずれかに記載の固形状の歯磨き組成物。
項５．
スルホコハク酸系界面活性剤が、スルホコハク酸モノラウリル２ナトリウム、ポリオキシエチレン（１）モノアルキル（炭素数１２〜１４）スルホコハク酸２ナトリウム、ポリオキシエチレン（２）モノアルキル（炭素数１２〜１４）スルホコハク酸２ナトリウム、ポリオキシエチレン（２）モノラウリルスルホコハク酸２ナトリウム、ポリオキシエチレン（２）モノアルキル（炭素数１２〜１４）スルホコハク酸２トリエタノールアミン、ポリオキシエチレン（３）モノアルキル（炭素数１２〜１４）スルホコハク酸２ナトリウム、ポリオキシエチレン（３）モノラウリルスルホコハク酸２ナトリウム、ポリオキシエチレン（３）モノラウリルスルホコハク酸マグネシウム、ポリオキシエチレン（３）モノヤシ油脂肪酸（炭素数８〜１８）スルホコハク酸２ナトリウム、ポリオキシエチレン（５）モノアルキル（炭素数１２〜１４）スルホコハク酸２ナトリウム、ポリオキシエチレン（５）モノヤシ油脂肪酸（炭素数８〜１８）スルホコハク酸２ナトリウム、ポリオキシエチレン（５）モノラウリルスルホコハク酸ジエタノールアミド、ポリオキシエチレン（５）ラウリルスルホコハク酸マグネシウム、ポリオキシエチレン（５）モノヤシ油脂肪酸（炭素数８〜１８）スルホコハク酸２ナトリウム、スルホコハク酸ポリオキシエチレン（５）ラウロイルエタノールアミド２ナトリウム、ポリオキシエチレン（７）モノアルキル（炭素数１２〜１４）スルホコハク酸２ナトリウム、及びポリオキシエチレン（７）モノラウリルスルホコハク酸マグネシウムからなる群より選択される少なくとも１種である、項４に記載の固形状の歯磨き組成物。
項６．
シクロデキストリンを含まない以外同じ組成の歯磨き組成物の泡立ちの程度の２５〜７５％（好ましくは３０〜７０％、より好ましくは３５〜６５％、さらに好ましくは４０〜６０％）の泡立ち程度である、項１〜５のいずれかに記載の固形状の歯磨き組成物。
項７．
泡立ち程度が、歯磨き組成物２５質量部に水７５質量部を加えて溶解し、往復振とう機に横向きに設置し、振とう幅４０ｍｍ、振とう速度１６０〜１７０ｒ／ｍｉｎ（ｒｐｍ）で５分間振とうしたときの、液面から泡の高さで評価される、項６に記載の固形状の歯磨き組成物。
項８．
シクロデキストリンが、スルホコハク酸系界面活性剤１００質量部に対して、０．０１２５〜２０００００質量部含まれる、項１〜７のいずれかに記載の固形状の歯磨き組成物。
The present invention includes, for example, the subjects described in the following sections.
Item 1.
A solid toothpaste composition containing a sulfosuccinic acid-based surfactant and cyclodextrin.
Item 2.
Item 2. The solid toothpaste composition according to Item 1, wherein the solid toothpaste composition is a paste-like, gel-like, or powder-like toothpaste composition.
Item 3.
Item 2. The solid toothpaste composition according to Item 1 or 2, wherein the cyclodextrin is at least one selected from the group consisting of β-cyclodextrin and γ-cyclodextrin.
Item 4.
The sulfosuccinic acid-based surfactant has a saturated or unsaturated alkyl group having 8 to 18 carbon atoms and an average number of molar additions of ethylene oxide of 0 to 7, which is monoalkyl sulfosuccinic acid / polyoxyethylene monoalkyl. Item 2. The solid toothpaste composition according to any one of Items 1 to 3, which is at least one selected from the group consisting of sulfosuccinic acid and salts thereof.
Item 5.
The sulfosuccinic acid-based surfactants are monolauryl sulfosuccinate disolauryl disodium, polyoxyethylene (1) monoalkyl (12-14 carbon atoms) disodium sulfosuccinate, polyoxyethylene (2) monoalkyl (12-14 carbon atoms). Disodium sulfosuccinate, polyoxyethylene (2) monolauryl disodium sulfosuccinate, polyoxyethylene (2) monoalkyl (12-14 carbon atoms) diethanolamine sulfosuccinate, polyoxyethylene (3) monoalkyl (carbon) Numbers 12-14) Disodium sulfosuccinate, polyoxyethylene (3) monolauryl sulfosuccinate disodium, polyoxyethylene (3) magnesium monolauryl sulfosuccinate, polyoxyethylene (3) monococonut oil fatty acids (8-18 carbon atoms) ) Disodium sulfosuccinate, polyoxyethylene (5) monoalkyl (12-14 carbon atoms) 2-sodium sulfosuccinate, polyoxyethylene (5) monococonut oil fatty acid (8-18 carbon atoms) disodium sulfosuccinate, polyoxyethylene (5) Monolauryl sulfosuccinic acid diethanolamide, polyoxyethylene (5) Magnesium lauryl sulfosuccinate, polyoxyethylene (5) Monococonut oil fatty acid (8 to 18 carbon atoms) Disodium sulfosuccinate, polyoxyethylene sulfosuccinate (5) At least one selected from the group consisting of lauroylethanolamide disodium, polyoxyethylene (7) monoalkyl (carbon 12-14) sulfosuccinate disodium, and polyoxyethylene (7) monolauryl sulfosuccinate magnesium. , Item 4. The solid toothpaste composition according to Item 4.
Item 6.
The degree of foaming of the toothpaste composition having the same composition except that it does not contain cyclodextrin is about 25 to 75% (preferably 30 to 70%, more preferably 35 to 65%, still more preferably 40 to 60%). , The solid toothpaste composition according to any one of Items 1 to 5.
Item 7.
The degree of foaming is dissolved by adding 75 parts by mass of water to 25 parts by mass of the toothpaste composition, installed sideways on a reciprocating shaker, and shaken at a shaking width of 40 mm and a shaking speed of 160 to 170 r / min (rpm) for 5 minutes. Item 6. The solid toothpaste composition according to Item 6, which is evaluated by the height of bubbles from the liquid surface when shaken.
Item 8.
Item 2. The solid toothpaste composition according to any one of Items 1 to 7, wherein cyclodextrin is contained in an amount of 0.0125 to 200,000 parts by mass with respect to 100 parts by mass of the sulfosuccinic acid-based surfactant.
本発明に係る固形状の歯磨き組成物であれば、スルホコハク酸系界面活性剤を含有しつつも使用時の泡立ちがステイン除去を目的とした歯磨きにおいて適度である。このため、本来歯磨き組成物が有するステイン除去効果を十分に得ることができ、また使用者が良好な使用感を得ることができ、また、十分に時間をかけて歯磨きできるため、歯牙表面に蓄積したステインを十分に除去することができる。 The solid toothpaste composition according to the present invention contains a sulfosuccinic acid-based surfactant, but foaming during use is appropriate for toothpaste for the purpose of removing stains. Therefore, the stain removing effect originally possessed by the toothpaste composition can be sufficiently obtained, the user can obtain a good feeling of use, and the toothpaste can be brushed over a sufficient period of time, so that it accumulates on the tooth surface. Toothpaste can be sufficiently removed.
以下、本発明の各実施形態について、さらに詳細に説明する。 Hereinafter, each embodiment of the present invention will be described in more detail.
本発明に包含される固形状の歯磨き組成物は、スルホコハク酸系界面活性剤及びシクロデキストリンを含む。 The solid dentifrice composition included in the present invention contains a sulfosuccinic acid-based surfactant and cyclodextrin.
スルホコハク酸系界面活性剤としては、エチレンオキシドの平均付加モル数が０〜７であるスルホコハク酸系活性剤が好ましい。 As the sulfosuccinic acid-based surfactant, a sulfosuccinic acid-based surfactant having an average addition mole number of ethylene oxide of 0 to 7 is preferable.
中でも、有するアルキル基が炭素数８〜１８の飽和又は不飽和のアルキル基で、エチレンオキサイドの平均付加モル数が０〜７であるモノアルキルスルホコハク酸／ポリオキシエチレンモノアルキルスルホコハク酸およびその塩からなる群より選択される少なくとも１種のスルホコハク酸系界面活性剤が好ましく挙げられる。このうち、炭素数が１２〜１６個のアルキル基で、エチレンオキサイドの平均付加モル数が０〜３であるスルホコハク酸系界面活性剤がより好ましい。なお、「モノアルキルスルホコハク酸／ポリオキシエチレンモノアルキルスルホコハク酸」の「／」は、エチレンオキサイドの平均付加モル数が０のときはモノアルキルスルホコハク酸であり、エチレンオキサイドの平均付加モル数が１〜７のときはポリオキシエチレンモノアルキルエーテルスルホコハク酸であることを示している。 Among them, from monoalkyl sulfosuccinic acid / polyoxyethylene monoalkyl sulfosuccinic acid and salts thereof, in which the alkyl group has a saturated or unsaturated alkyl group having 8 to 18 carbon atoms and the average number of moles of ethylene oxide added is 0 to 7. At least one sulfosuccinic acid-based surfactant selected from the above group is preferably mentioned. Of these, a sulfosuccinic acid-based surfactant having an alkyl group having 12 to 16 carbon atoms and an average addition mole number of ethylene oxide of 0 to 3 is more preferable. The "/" in "monoalkyl sulfosuccinic acid / polyoxyethylene monoalkyl sulfosuccinic acid" is monoalkyl sulfosuccinic acid when the average number of moles of ethylene oxide added is 0, and the average number of moles of ethylene oxide added is 1. When it is ~ 7, it indicates that it is polyoxyethylene monoalkyl ether sulfosuccinic acid.
より具体的には、、例えば、スルホコハク酸モノラウリル２ナトリウム、ポリオキシエチレン（１）モノアルキル（炭素数１２〜１４）スルホコハク酸２ナトリウム、ポリオキシエチレン（２）モノアルキル（炭素数１２〜１４）スルホコハク酸２ナトリウム、ポリオキシエチレン（２）モノラウリルスルホコハク酸２ナトリウム、ポリオキシエチレン（２）モノアルキル（炭素数１２〜１４）スルホコハク酸２トリエタノールアミン、ポリオキシエチレン（３）モノアルキル（炭素数１２〜１４）スルホコハク酸２ナトリウム、ポリオキシエチレン（３）モノラウリルスルホコハク酸２ナトリウム、ポリオキシエチレン（３）モノラウリルスルホコハク酸マグネシウム、ポリオキシエチレン（３）モノヤシ油脂肪酸（炭素数８〜１８）スルホコハク酸２ナトリウム、ポリオキシエチレン（５）モノアルキル（炭素数１２〜１４）スルホコハク酸２ナトリウム、ポリオキシエチレン（５）モノヤシ油脂肪酸（炭素数８〜１８）スルホコハク酸２ナトリウム、ポリオキシエチレン（５）モノラウリルスルホコハク酸ジエタノールアミド、ポリオキシエチレン（５）ラウリルスルホコハク酸マグネシウム、ポリオキシエチレン（５）モノヤシ油脂肪酸（炭素数８〜１８）スルホコハク酸２ナトリウム、スルホコハク酸ポリオキシエチレン（５）ラウロイルエタノールアミド２ナトリウム、ポリオキシエチレン（７）モノアルキル（炭素数１２〜１４）スルホコハク酸２ナトリウム、ポリオキシエチレン（７）モノラウリルスルホコハク酸マグネシウム等が挙げられ、このうち、スルホコハク酸モノラウリル２ナトリウム、ポリオキシエチレン（１）モノアルキル（炭素数１２〜１４）スルホコハク酸２ナトリウム、ポリオキシエチレン（２）モノアルキル（炭素数１２〜１４）スルホコハク酸２ナトリウム、ポリオキシエチレン（２）モノラウリルスルホコハク酸２ナトリウム、ポリオキシエチレン（３）モノアルキル（炭素数１２〜１４）スルホコハク酸２ナトリウム、ポリオキシエチレン（３）モノラウリルスルホコハク酸２ナトリウム、ポリオキシエチレン（５）モノアルキル（炭素数１２〜１４）スルホコハク酸２ナトリウム、ポリオキシエチレン（７）モノアルキル（炭素数１２〜１４）スルホコハク酸２ナトリウムがより好ましく、スルホコハク酸ラウリル２ナトリウム、ポリオキシエチレン（２）モノアルキル（炭素数１２〜１４）スルホコハク酸２ナトリウム、ポリオキシエチレン（３）モノアルキル（炭素数１２〜１４）スルホコハク酸２ナトリウムが中でも好ましい。 More specifically, for example, monolauryl sulfosuccinate disolauryl disodium, polyoxyethylene (1) monoalkyl (12 to 14 carbon atoms) disodium sulfosuccinate, polyoxyethylene (2) monoalkyl (12 to 14 carbon atoms). ) Disodium sulfosuccinate, polyoxyethylene (2) monolauryl disodium sulfosuccinate, polyoxyethylene (2) monoalkyl (12-14 carbon atoms) diethanolamine sulfosuccinate, polyoxyethylene (3) monoalkyl ( 12-14 carbon atoms) 2 sodium sulfosuccinate, polyoxyethylene (3) monolauryl sulfosuccinate disodium, polyoxyethylene (3) magnesium monolauryl sulfosuccinate, polyoxyethylene (3) monococonut oil fatty acid (8 to 14 carbon atoms) 18) Disodium sulfosuccinate, polyoxyethylene (5) monoalkyl (12-14 carbon atoms) disodium sulfosuccinate, polyoxyethylene (5) monococonut oil fatty acid (8-18 carbon atoms) disodium sulfosuccinate, polyoxy Ethylene (5) monolauryl sulfosuccinate diethanolamide, polyoxyethylene (5) magnesium lauryl sulfosuccinate, polyoxyethylene (5) monococonut oil fatty acid (carbon number 8-18) disodium sulfosuccinate, polyoxyethylene sulfosuccinate (5) ) Lauroylethanolamide disodium, polyoxyethylene (7) monoalkyl (12 to 14 carbon atoms) disodium sulfosuccinate, polyoxyethylene (7) monolauryl magnesium sulfosuccinate, etc. Among them, monolauryl sulfosuccinate. 2 sodium, polyoxyethylene (1) monoalkyl (12-14 carbon atoms) disodium sulfosuccinate, polyoxyethylene (2) monoalkyl (12-14 carbon atoms) disodium sulfosuccinate, polyoxyethylene (2) mono 2 sodium lauryl sulfosuccinate, polyoxyethylene (3) monoalkyl (12-14 carbon atoms) 2 sodium sulfosuccinate, polyoxyethylene (3) 2 sodium monolauryl sulfosuccinate, polyoxyethylene (5) monoalkyl (carbon number) 12-14) disodium sulfosuccinate, polyoxyethylene (7) monoalkyl (12-14 carbon atoms) disodium sulfosuccinate is more preferred, and disodium lauryl sulfosuccinate, polyoxyethylene (2) monoalkyl (2) monoalkyl ( Of these, disodium sulfosuccinate (12 to 14 carbon atoms) and disodium polyoxyethylene (3) monoalkyl (12 to 14 carbon atoms) disodium sulfosuccinate are particularly preferable.
スルホコハク酸系界面活性剤は１種単独で又は２種以上を組み合わせて用いることができる。特にマグネシウム塩を用いる場合にはナトリウム塩と併用することが好ましい。ヤシ油脂肪酸のアルキル基分布は、炭素数が８〜１８のものを使用できるが、１０〜１８がより好ましく、１０〜１６が最も好ましい。 The sulfosuccinic acid-based surfactant may be used alone or in combination of two or more. In particular, when a magnesium salt is used, it is preferable to use it in combination with a sodium salt. As the alkyl group distribution of the coconut oil fatty acid, those having 8 to 18 carbon atoms can be used, but 10 to 18 is more preferable, and 10 to 16 is most preferable.
なお、上記のポリオキシエチレンの後の括弧書きの数字は、エチレンオキシドの付加モル数の平均値を意味する。ポリオキシエチレンはＰＯＥと記載されることがある。 The numbers in parentheses after the above polyoxyethylene mean the average number of moles of ethylene oxide added. Polyoxyethylene is sometimes referred to as POE.
本発明に用いるシクロデキストリンとしては、α−シクロデキストリン、β−シクロデキストリン、及びγ−シクロデキストリンが好ましい。中でもβ−シクロデキストリン及びγ−シクロデキストリンが好ましい。シクロデキストリンは１種単独で又は２種以上を組み合わせて用いることができる。 As the cyclodextrin used in the present invention, α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin are preferable. Of these, β-cyclodextrin and γ-cyclodextrin are preferable. Cyclodextrin can be used alone or in combination of two or more.
シクロデキストリンの含有量としては、組成物全量に対して、０．００５〜５質量％程度であることが好ましく、０.０１〜２質量％程度がより好ましく、０．０５〜１質量％程度がさらに好ましい。 The content of cyclodextrin is preferably about 0.005 to 5% by mass, more preferably about 0.01 to 2% by mass, and about 0.05 to 1% by mass with respect to the total amount of the composition. More preferred.
また、シクロデキストリンは、スルホコハク酸系界面活性剤１００質量部に対して、０．０１２５〜２０００００質量部程度含まれることが好ましく、０．２５〜２００００質量部程度含まれることがより好ましく、０．５〜２０００質量部程度がさらに好ましい。当該範囲の中でも、シクロデキストリンは、スルホコハク酸系界面活性剤１００質量部に対して、１〜１０００質量部程度含まれることが好ましく、２〜５００質量部程度含まれることがより好ましく、２．５〜１００質量部程度含まれることがさらに好ましく、５〜５０質量部程度含まれることがよりさらに好ましい。 Further, cyclodextrin is preferably contained in an amount of about 0.0125 to 200,000 parts by mass, more preferably about 0.25 to 20,000 parts by mass, and 0. It is more preferably about 5 to 2000 parts by mass. Within this range, cyclodextrin is preferably contained in an amount of about 1 to 1000 parts by mass, more preferably about 2 to 500 parts by mass, and more preferably 2.5 parts by mass with respect to 100 parts by mass of the sulfosuccinic acid-based surfactant. It is more preferably contained in an amount of about 100 parts by mass, and further preferably contained in an amount of about 5 to 50 parts by mass.
固形状の歯磨き組成物としては、例えば、ペースト状、ジェル状、又は粉状の歯磨き組成物を好ましく挙げることができる。これらペースト状、ジェル状、又は粉状の歯磨き組成物は、例えば練歯磨組成物、粉歯磨組成物、潤性歯磨組成物、ゲル類、クリーム類、パスタ類等の歯磨き組成物を好ましく包含する。このような剤形の歯磨き組成物は公知の方法（特に常法）によって調製することができる。 As the solid toothpaste composition, for example, a paste-like, gel-like, or powder-like toothpaste composition can be preferably mentioned. These paste-like, gel-like, or powder-like toothpaste compositions preferably include toothpaste compositions such as toothpaste compositions, powder toothpaste compositions, moisturizing toothpaste compositions, gels, creams, and pasta. .. Toothpaste compositions in such dosage forms can be prepared by known methods (particularly conventional methods).
本発明に係る固形状の歯磨き組成物は、スルホコハク酸系界面活性剤を含有する一方で、歯磨き時（好ましくは当該組成物を用いた歯のブラッシング時）における泡立ちが適度（多すぎず少なすぎない）である。特に制限はされないが、当該固形状の歯磨き組成物使用時の泡立ちの程度は、好ましくは、シクロデキストリンを含まない以外は同じ組成の歯磨き組成物使用時の泡立ちの２５〜７５％程度であり、より好ましくは３０〜７０％程度、さらに好ましくは３５〜６５％程度、よりさらに好ましくは４０〜６０％程度である。 While the solid toothpaste composition according to the present invention contains a sulfosuccinic acid-based surfactant, foaming during tooth brushing (preferably when brushing teeth using the composition) is moderate (not too much but too little). Not). Although not particularly limited, the degree of foaming when the solid toothpaste composition is used is preferably about 25 to 75% of the foaming when the toothpaste composition having the same composition is used except that it does not contain cyclodextrin. It is more preferably about 30 to 70%, further preferably about 35 to 65%, and even more preferably about 40 to 60%.
ここでの「泡立ち」は、歯磨き組成物２５質量部に水７５質量部を加えて溶解し、往復振とう機に横向きに設置し、振とう幅４０ｍｍ、振とう速度１６０〜１７０ｒ／ｍｉｎ（ｒｐｍ）で５分間振とうしたときの、液面から泡の高さで評価される。 For "foaming" here, 75 parts by mass of water is added to 25 parts by mass of the toothpaste composition to dissolve it, and the toothpaste is placed sideways on a reciprocating shaker, with a shaking width of 40 mm and a shaking speed of 160 to 170 r / min (rpm). ) For 5 minutes, the height of the bubbles from the liquid level is evaluated.
本発明の組成物は、本発明の効果を損なわない範囲で、さらに界面活性剤を含有しても良い。但し、界面活性剤は歯磨き組成物の泡立ちを増加させる可能性が高いことから、さらに配合させる場合には注意が必要である。さらに配合される界面活性剤の全組成物に対する含有量は、おおむね、０．０１〜１質量％の範囲内であることが好ましい。このような界面活性剤としては、例えば、アルキル硫酸塩（好ましくはナトリウム塩）が挙げられる。（アルキル硫酸塩としては、炭素数８〜１８の飽和又は不飽和のアルキル基であるアルキル硫酸塩が挙げられる。このうち、アルキル基の炭素数が１０〜１８が好ましく、１０〜１６がより好ましく、１０〜１２がさらに好ましく、１２が最も好ましい。） The composition of the present invention may further contain a surfactant as long as the effects of the present invention are not impaired. However, since the surfactant has a high possibility of increasing the foaming of the dentifrice composition, care must be taken when further blending it. The content of the surfactant to be further blended with respect to the total composition is preferably in the range of about 0.01 to 1% by mass. Examples of such a surfactant include alkyl sulfates (preferably sodium salts). (Examples of the alkyl sulfate include an alkyl sulfate which is a saturated or unsaturated alkyl group having 8 to 18 carbon atoms. Of these, the alkyl group preferably has 10 to 18 carbon atoms, more preferably 10 to 16 carbon atoms. , 10-12 is more preferable, and 12 is the most preferable.)
また、ノニオン界面活性剤、上述したスルホコハク酸系界面活性剤およびアルキル硫酸ナトリウム以外のアニオン界面活性剤、および両性イオン界面活性剤も挙げられる。ノニオン界面活性剤としては、例えば、ポリオキシエチレンソルビタン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリエチレングリコール脂肪酸エステル、ポリオキシエチレンステロール、ポリオキシエチレン硬化ヒマシ油、ショ糖脂肪酸エステル、マルトース脂肪酸エステル、ラクトース脂肪酸エステル等の糖脂肪酸エステル、脂肪酸アルカノールアミド類、ソルビタン脂肪酸エステル、脂肪酸モノグリセライド、エチレンオキシドの平均付加モル数が４〜１６であり、且つ、アルキル基の炭素数が１０〜１８であるポリオキシエチレンアルキルエーテル、またはエチレンオキシドの平均付加モル数が９であり、且つ、アルキル基の炭素数が１０〜１８であるポリオキシエチレンアルキルフェニルエーテル、セバシン酸ジエチル、ポリオキシエチレンソルビット脂肪酸エステル、ポリオキシエチレンラノリン、ポリオキシエチレンラノリンアルコール、アルキルグルコシド、ポリオキシエチレンポリオキシプロピレンブロックコポリマー等が挙げられる。また、アニオン界面活性剤としては、例えば、ポリオキシエチレン（３）ラウリルエーテル硫酸ナトリウム等のポリオキシエチレンアルキル硫酸エステル塩、Ｎ−ラウロイルサルコシンナトリウムやＮ−ラウロイルメチルアラニンナトリウム、Ｎ−ラウロイル−Ｌ−グルタミン酸カリウム、Ｎ−ラウロイル−Ｌ−アスパラギン酸ナトリウム、Ｎ−ヤシ油脂肪酸アシルグリシンカリウム等のＮ−アシルアミノ酸塩、ココイルメチルタウリン等のＮ−アシルタウリン塩、ポリオキシエチレン（４）ラウリルエーテル酢酸ナトリウム等のアルキルエーテルカルボン酸塩が挙げられる。両性イオン界面活性剤としては、例えば、ラウリルジメチルアミノ酢酸ベタイン、ヤシ油脂肪酸アミドプロピルジメチルアミノ酢酸ベタイン等の酢酸ベタイン型活性剤、Ｎ−ココイル−Ｎ−カルボキシメチル−Ｎ−ヒドロキシエチルエチレンジアミンナトリウム等のイミダゾリン型活性剤等が挙げられる。これらのスルホコハク酸系界面活性剤以外の界面活性剤は、１種単独で、または２種以上を組み合わせて用いることができる。 In addition, nonionic surfactants, anionic surfactants other than the above-mentioned sulfosuccinic acid-based surfactants and sodium alkyl sulfates, and amphoteric ion surfactants are also mentioned. Examples of nonionic surfactants include polyoxyethylene sorbitan fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene sterol, polyoxyethylene hydrogenated castor oil, and sucrose fatty acid ester. The average number of moles of sugar fatty acid esters such as maltose fatty acid ester and lactose fatty acid ester, fatty acid alkanolamides, sorbitan fatty acid ester, fatty acid monoglyceride, and ethylene oxide is 4 to 16, and the number of carbon atoms of the alkyl group is 10 to 18. A polyoxyethylene alkyl ether, or a polyoxyethylene alkyl phenyl ether having an average addition molar number of 9 and an alkyl group having 10 to 18 carbon atoms, diethyl sebacate, polyoxyethylene sorbit fatty acid ester, Examples thereof include polyoxyethylene lanolin, polyoxyethylene lanolin alcohol, alkyl glucoside, and polyoxyethylene polyoxypropylene block copolymer. Examples of the anionic surfactant include polyoxyethylene alkyl sulfates such as polyoxyethylene (3) sodium lauryl ether sulfate, sodium N-lauroyl sarcosin, sodium N-lauroylmethylalanine, and N-lauroyl-L-. N-acylamino acid salts such as potassium glutamate, sodium N-lauroyl-L-aspartate, N-palm oil fatty acid acylglycine potassium, N-acyl taurine salts such as cocoyl methyl taurine, polyoxyethylene (4) sodium lauryl ether acetate Alkyl ether carboxylate and the like. Examples of the amphoteric ion surfactant include betaine acetate-type activators such as lauryldimethylaminoacetate betaine and coconut oil fatty acid amide propyldimethylaminoacetic acid betaine, and N-cocoyl-N-carboxymethyl-N-hydroxyethylethylenediamine sodium. Examples include imidazoline type activators. Surfactants other than these sulfosuccinic acid-based surfactants can be used alone or in combination of two or more.
本発明の組成物は、更に粘結剤を含有してもよい。当該粘結剤の全組成物に対する含有量は、おおむね、０．１〜８質量％の範囲内であることが好ましい。本発明に用いられる粘結剤として、例えば、カルボキシメチルセルロースナトリウム、カルボキシメチルエチルセルロース塩、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロースなどのセルロース誘導体、キサンタンガム、ジェランガムなどの微生物産生高分子、トラガントガム、カラヤガム、アラビヤガム、カラギーナン、デキストリンなどの天然高分子または天然ゴム類、ポリビニルアルコール、ポリビニルピロリドンなどの合成高分子、増粘性シリカ、ビーガムなどの無機粘結剤、塩化Ｏ−［２−ヒドロキシ−３−（トリメチルアンモニオ）プロピル］ヒドロキシエチルセルロースなどのカチオン性粘結剤が挙げられる。これらの粘結剤は、単独で、または２種以上を組み合わせて使用することができる。 The composition of the present invention may further contain a binder. The content of the binder in the total composition is preferably in the range of 0.1 to 8% by mass. Examples of the binder used in the present invention include cellulose derivatives such as sodium carboxymethyl cellulose, carboxymethyl ethyl cellulose salt, hydroxyethyl cellulose, hydroxypropyl cellulose and hydroxypropyl methyl cellulose, microbially produced polymers such as xanthan gum and gellan gum, tragant gum and carrageenan gum. Natural polymers or natural rubbers such as arabiya gum, carrageenan and dextrin, synthetic polymers such as polyvinyl alcohol and polyvinylpyrrolidone, inorganic binders such as thickening silica and bee gum, O- [2-hydroxy-3- (trimethyl) chloride Ammonio) propyl] Hydroxyethyl cellulose and other cationic binders can be mentioned. These binders can be used alone or in combination of two or more.
本発明の組成物は、更に甘味剤を含有してもよい。当該甘味剤の全組成物に対する含有量は、おおむね、０．００１〜１０質量％の範囲内であることが好ましい。本発明に用いられる甘味剤として、例えば、サッカリン、サッカリンナトリウム、アセスルファームカリウム、スクラロース、Ｌ−フェニルアラニン、ステビアエキス、ステビオサイド、ネオヘスペリジルジヒドロカルコン、グリチルリチン、ペリラルチン、ソウマチン、アスパルチルフェニルアラニンメチルエステル、メトキシシンナミックアルデヒド、パラチノース、パラチニット、エリスリトール、マルチトール、キシリトール、ラクチトールなどが挙げられる。これらの甘味剤は、単独で、または２種以上を組み合わせて使用することができる。 The composition of the present invention may further contain a sweetener. The content of the sweetening agent in the total composition is preferably in the range of 0.001 to 10% by mass. As the sweetener used in the present invention, for example, saccharin, sodium saccharin, acesulfarm potassium, sucralose, L-phenylalanine, stevia extract, stebioside, neohesperidyldihydrochalcone, glycyrrhizin, perilaltin, soumatin, aspartylphenylalanine methyl ester, methoxy Examples thereof include synamic aldehyde, palatinose, palatinit, erythritol, maltitol, xylitol and lactitol. These sweeteners can be used alone or in combination of two or more.
本発明の組成物は、更に湿潤剤を含有してもよい。当該湿潤剤の全組成物に対する含有量は、おおむね、１〜６０質量％の範囲内であることが好ましい。本発明に用いられる湿潤剤として、例えば、グリセリン、エチレングリコール、プロピレングリコール、ブタンジオール、ペンタンジオール、ヘキサンジオール、オクタンジオ−ル、ソルビトール、ポリエチレングリコール（例えばＰＥＧ４００、ＰＥＧ４０００等）、ポリプロピレングリコールなどが挙げられる。これらの湿潤剤は、単独で、または２種以上を組み合わせて使用することができる。 The composition of the present invention may further contain a wetting agent. The content of the wetting agent in the total composition is preferably in the range of 1 to 60% by mass. Examples of the wetting agent used in the present invention include glycerin, ethylene glycol, propylene glycol, butanediol, pentandiol, hexanediol, octanediol, sorbitol, polyethylene glycol (for example, PEG400, PEG4000, etc.), polypropylene glycol and the like. .. These wetting agents can be used alone or in combination of two or more.
本発明の組成物は、更に保存剤を含有してもよい。当該保存剤の全組成物に対する含有量は、おおむね、０．０１〜１質量％の範囲内であることが好ましい。本発明に用いられる保存剤として、例えば、ｐ−ヒドロキシ安息香酸メチル、ｐ−ヒドロキシ安息香酸エチル、ｐ−ヒドロキシ安息香酸プロピル、ｐ−ヒドロキシ安息香酸ブチルなどのｐ−ヒドロキシ安息香酸エステル、安息香酸ナトリウムなどの安息香酸塩、フェノキシエタノールなどのフェノール類などが挙げられる。これらの保存剤は、単独で、または２種以上を組み合わせて使用することができる。 The composition of the present invention may further contain a preservative. The content of the preservative in the total composition is preferably in the range of 0.01 to 1% by mass. Examples of the preservative used in the present invention include p-hydroxybenzoic acid esters such as methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate, and butyl p-hydroxybenzoate, and sodium benzoate. Examples thereof include benzoate such as benzoate and phenols such as phenoxyethanol. These preservatives can be used alone or in combination of two or more.
本発明の組成物は、更に歯牙研磨剤を含有してもよい。このような歯牙研磨剤としては、例えば沈降シリカ（特に研磨性沈降シリカ）、ゲル法シリカ、ヒュームド法シリカ、ジルコノシリケート、ケイ酸アルミニウム、リン酸カルシウム、第２リン酸カルシウム・無水和物、第２リン酸カルシウム・２水和物、第３リン酸カルシウム、リン酸水素カルシウム・無水和物、リン酸水素カルシウム・２水和物、ピロリン酸カルシウム、炭酸カルシウム、硫酸カルシウム、水酸化アルミニウム、不溶性メタリン酸ナトリウム、第３リン酸マグネシウム、炭酸マグネシウム、酸化チタン、ポリメタクリル酸メチル、ベントナイト、ハイドロキシアパタイト、結晶セルロース、合成樹脂（例えばポリエチレンビーズ、ポリプロピレンビーズ）等が挙げられる。これらのなかでも、特に沈降シリカが好ましい。また、このような歯牙研磨剤は、単独又は２種以上を組み合わせて用いることができる。 The composition of the present invention may further contain a tooth abrasive. Examples of such tooth polishes include precipitated silica (particularly abrasive precipitated silica), gel-type silica, fumed-type silica, zirconosilicate, aluminum silicate, calcium phosphate, dicalcium phosphate / anhydride, and calcium dibasic phosphate. Dihydrate, tricalcium phosphate, calcium hydrogen phosphate / anhydrous, calcium hydrogen phosphate / dihydrate, calcium pyrophosphate, calcium carbonate, calcium sulfate, aluminum hydroxide, insoluble sodium metaphosphate, triphosphate Examples thereof include magnesium, magnesium carbonate, titanium oxide, polymethyl methacrylate, bentonite, hydroxyapatite, crystalline cellulose, synthetic resin (for example, polyethylene beads, polypropylene beads) and the like. Of these, precipitated silica is particularly preferable. In addition, such a tooth abrasive can be used alone or in combination of two or more.
本発明の組成物は、更に薬効成分を含有してもよい。但し、スルホコハク酸系界面活性剤と併用すると沈殿を生じ易い薬効成分も存在する（例えば塩化セチルピリジニウムなどのカチオン系化合物）ため、使用する場合には使用量に注意すべきである。上記薬効成分の全組成物に対する含有量は、おおむね、０．００１〜１質量％の範囲内であることが好ましい。 The composition of the present invention may further contain a medicinal ingredient. However, since there are some medicinal ingredients that easily cause precipitation when used in combination with a sulfosuccinic acid-based surfactant (for example, a cationic compound such as cetylpyridinium chloride), care should be taken when using it. The content of the medicinal ingredient with respect to the total composition is preferably in the range of 0.001 to 1% by mass.
本発明に用いられる薬効成分として、例えば、殺菌剤として、塩化セチルピリジニウム、塩化ベンゼトニウム、塩化ベンザルコニウム、グルコン酸クロルヘキシジン、塩酸クロルヘキシジン、塩化セチルピリジニウムなどのカチオン性殺菌剤；ドデシルジアミノエチルグリシンなどの両性殺菌剤、トリクロサン（２’，４，４’−トリクロロ−２−ヒドロキシ−ジフェニルエーテル）などのハロゲン化ジフェニルエーテルやイソプロピルメチルフェノールなどのフェノール系殺菌剤、ヒノキチオール；血行促進剤として酢酸ｄｌ−α−トコフェロール、コハク酸トコフェロール、ニコチン酸トコフェロールなどのビタミンＥ類；デキストラナーゼ、アミラーゼ、プロテアーゼ、ムタナーゼ、リゾチーム、溶菌酵素（リテックエンザイム）などの酵素；抗炎症剤としてグリチルレチン酸、グリチルリチン酸ジカリウムなどのグリチルリチン酸塩；抗プラスミン剤としてトラネキサム酸、イプシロンアミノカプロン酸など；出血改善剤としてアスコルビン酸など；組織修復剤としてアラントインなど；再石灰化剤としてフッ化ナトリウムなどのフッ素化合物；その他、水溶性溶媒で抽出された植物抽出物、クロロフィル、塩化ナトリウム、塩化亜鉛などが挙げられる。これらの薬効成分は、単独で、または２種以上を組み合わせて用いることができる。 As the medicinal ingredient used in the present invention, for example, as a disinfectant, a cationic disinfectant such as cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, chlorhexidine gluconate, chlorhexidine hydrochloride, cetylpyridinium chloride; dodecyldiaminoethylglycine Amphoteric disinfectants, phenolic disinfectants such as diphenyl ether halides such as triclosan (2', 4,4'-trichloro-2-hydroxy-diphenyl ether) and phenolic disinfectants such as isopropylmethylphenol, hinokithiol; dl-α-tocopherol acetate as a blood circulation promoter , Vitamin Es such as tocopherol succinate, tocopherol nicotinate; enzymes such as dextranase, amylases, proteases, mutanases, lysozymes, lytic enzymes (lytecenzymes); Salts; tranexamic acid, epsilon aminocaproic acid, etc. as anti-plasmin agents; ascorbic acid, etc. as bleeding improvers; allantin, etc. as tissue repair agents; fluorine compounds such as sodium fluoride as remineralizing agents; other, extracted with water-soluble solvents Examples include plant extracts, chlorophyll, sodium chloride, zinc chloride and the like. These medicinal ingredients can be used alone or in combination of two or more.
本発明の組成物は、更に香料を含有することができる。上記香料の全組成物に対する含有量は、おおむね、０．０１〜１質量％の範囲内であることが好ましい。本発明に用いられる香料として、例えば、メントール、メントン、イソメントン、乳酸メンチル、酢酸テルピニル、チモール、ターピネオール、オイゲノール、リナロール、ゲラニオール、シトロネロール、カルボン、サリチル酸メチル、バニリン、ベンジルサクシネート、メチルオイゲノール、アネトール、リモネン、オシメン、ｎ−デシルアルコール、メチルアセタート、シトロネニルアセテート、シネオール、エチルリナロール、ワニリン、タイム、ナツメグ、スペアミント油、ペパーミント油、レモン油、オレンジ油、グレープフルーツ油、セージ油、ローズマリー油、珪皮油、シソ油、冬緑油、丁子油、ユーカリ油、ピメント油、ティーツリー油、タバナ油、スターアニス油、コリアンダー油、ハッカ油、フェンネル油、珪藻油、バジル油などが挙げられる。これらの香料は、単独で、または２種以上を組み合わせて使用することができる。 The composition of the present invention can further contain a fragrance. The content of the fragrance in the total composition is preferably in the range of 0.01 to 1% by mass. The fragrances used in the present invention include, for example, menthol, menton, isomentone, menthyl lactate, terpinyl acetate, timol, tarpineol, eugenol, linalool, geraniol, citronellol, carboxylic, methyl salicylate, vanillin, benzyl succinate, methyl eugenol, anetol, Limonene, osimene, n-decyl alcohol, methyl acetate, citronenyl acetate, cineol, ethyl linalool, crocodile, thyme, star anise, spearmint oil, peppermint oil, lemon oil, orange oil, grapefruit oil, sage oil, rosemary oil , Silica skin oil, perilla oil, winter green oil, clove oil, eucalyptus oil, piment oil, tea tree oil, tabana oil, star anise oil, coriander oil, peppermint oil, fennel oil, diatomaceous oil, basil oil, etc. .. These fragrances can be used alone or in combination of two or more.
なお、本明細書において「含む」とは、「本質的にからなる」と、「からなる」をも包含する（The term "comprising" includes "consisting essentially of” and "consisting of."）。 In addition, in this specification, "including" also includes "consisting essentially" and "consisting of" (The term "comprising" includes "consisting essentially of" and "consisting of.").
以下、本発明をより具体的に説明するが、本発明は下記の例に限定されるものではない。なお、以下特に断らない限り、「％」は「質量％」を表す。 Hereinafter, the present invention will be described in more detail, but the present invention is not limited to the following examples. Unless otherwise specified, "%" represents "mass%".
歯磨き組成物の調製及び泡立ち評価
表１に記載の組成に従い、常法によりペースト状の歯磨き組成物を調製した。なお、表１に記載の各成分値は質量％を示す。また、以下、表中の「ソルビトール液」はソルビトール７０質量％水溶液である。
Preparation and Foaming Evaluation of Toothpaste Composition A paste-like toothpaste composition was prepared by a conventional method according to the composition shown in Table 1. In addition, each component value shown in Table 1 shows mass%. Further, hereinafter, the "sorbitol solution" in the table is a 70% by mass aqueous solution of sorbitol.
そして、各実施例及び比較例の歯磨き組成物につき、次のようにして泡立ちを評価した。 Then, for each of the toothpaste compositions of Examples and Comparative Examples, foaming was evaluated as follows.
各例の歯磨き組成物それぞれに２５ｇに水を加えて１００ｇとし、均一になるよう静かに液を攪拌子にて攪拌した。組成物が十分に溶解したら、各試験液を５０ｍＬのフタ付き試験管に１５ｍＬとり、フタをして往復振とう機に横向きに設置し、振とう幅４０ｍｍ、振とう速度１６０〜１７０ｒ／ｍｉｎで５分間振とうした。取り出し後、試験管の液面がほぼ水平になるよう立てて、液面から泡の高さ（泡立ち）を測定した。 Water was added to 25 g of each of the toothpaste compositions of each example to make 100 g, and the liquid was gently stirred with a stir bar so as to be uniform. When the composition is sufficiently dissolved, take 15 mL of each test solution in a 50 mL test tube with a lid, cover it and place it sideways on a reciprocating shaker, with a shaking width of 40 mm and a shaking speed of 160 to 170 r / min. Shake for 5 minutes. After taking out, the test tube was erected so that the liquid level was almost horizontal, and the height of bubbles (foaming) was measured from the liquid level.
結果を図１に示す。図１では、左から実施例１（１４ｍｍ）、実施例２（１０ｍｍ）、実施例３（９ｍｍ）、比較例１（２０ｍｍ）、の順に泡の高さ（泡立ち）を棒グラフで示す。 The results are shown in FIG. In FIG. 1, the height (foaming) of bubbles is shown in a bar graph in the order of Example 1 (14 mm), Example 2 (10 mm), Example 3 (9 mm), and Comparative Example 1 (20 mm) from the left.
歯磨き組成物の使用評価
被験者（８５名）に実施例２の歯磨き組成物を２週間使用してもらい、その後、時間をかけて磨くのに適した泡量であるかについて、以下の評価基準で評価をしてもらった。
１．非常に適している。
２．やや適している。
３．あまり適していない。
４．まったく適していない。
Evaluation of Use of Toothpaste Composition We asked subjects (85 people) to use the toothpaste composition of Example 2 for 2 weeks, and then determined whether the amount of foam was suitable for brushing over time according to the following evaluation criteria. I got an evaluation.
1. 1. Very suitable.
2. 2. Somewhat suitable.
3. 3. Not very suitable.
4. Not suitable at all.
評価の集計結果を表２に示す。表２の％は、各項目を選択した被験者の割合を示す。 Table 2 shows the aggregated results of the evaluations. % In Table 2 shows the percentage of subjects who selected each item.
以下に、本発明の固形状の歯磨き組成物の処方例を挙げる。なお、処方例の各成分の数値は質量％を示す。 The following is a prescription example of the solid toothpaste composition of the present invention. The numerical value of each component of the formulation example indicates mass%.
Claims (4)
前記スルホコハク酸系界面活性剤が、有するアルキル基が炭素数８〜１８の飽和又は不飽和のアルキル基、エチレンオキサイドの平均付加モル数が０〜７、であるモノアルキルスルホコハク酸／ポリオキシエチレンモノアルキルスルホコハク酸およびその塩からなる群より選択される少なくとも１種である、
固形状の歯磨き組成物。 Contains sulfosuccinic acid-based surfactant and cyclodextrin ,
The sulfosuccinic acid-based surfactant has a monoalkyl sulfosuccinic acid / polyoxyethylene mono having an alkyl group having a saturated or unsaturated alkyl group having 8 to 18 carbon atoms and an average addition molar number of ethylene oxide of 0 to 7. At least one selected from the group consisting of alkylsulfosuccinic acid and salts thereof,
A solid toothpaste composition.
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