WO2009091050A1

WO2009091050A1 - Composition for oral application

Info

Publication number: WO2009091050A1
Application number: PCT/JP2009/050587
Authority: WO
Inventors: Naomi Yasuda
Original assignee: Sunstar Inc.
Priority date: 2008-01-16
Filing date: 2009-01-16
Publication date: 2009-07-23
Also published as: JP5404424B2; JPWO2009091050A1

Abstract

Disclosed is a composition for oral application, into which a lactic acid bacterium can be blended alive stably, which has largely improved bitter taste and harsh taste even when the composition has a low water content, and which has shape-retaining properties and proper stringiness. Specifically disclosed is a composition for oral application, which is characterized by comprising a lactic acid bacterium, 1,3-butylene glycol and hydroxyethylcellulose.

Description

Oral composition

The present invention relates to an oral composition, and in particular, relates to an oral composition that stably contains lactic acid bacteria and has excellent shape retention and taste.

The oral composition may contain various active ingredients in the preparation for the purpose of imparting function and efficacy. The active ingredients include fluoride, bactericidal ingredients, anti-inflammatory ingredients, anticalculus ingredients, hemostasis Agents and the like. In recent years, lactic acid bacteria, plant extracts, herbal medicines and the like have been incorporated into oral compositions as natural bactericidal and bacteriostatic components that are gentle on the human body and have few side effects. In particular, lactic acid bacteria are considered to act as bacteriostatic agents for periodontal disease and periodontal disease by acting in the oral cavity where caries-causing bacteria and periodontal disease-causing bacteria are present. It is attracting attention as an active ingredient gentle to the human body with less adverse effects such as side effects.

However, lactic acid bacteria are easily affected by moisture and chemical substances, and it is difficult to stably mix lactic acid bacteria for a long period of time. From such a point of view, it is conceivable to reduce the water content, but since such oral compositions contain a large amount of organic solvents other than water, in addition to the stability of lactic acid bacteria, bitterness, gummy taste, etc. There are many cases where the taste is difficult.

Further, in general oral compositions, for example, a thickener such as sodium carboxymethylcellulose, carrageenan, or xanthan gum is mainly blended, and these components dissolve in water to develop viscosity, and powder components And liquid components are combined to give shape retention and moderate viscosity. However, in oral compositions with low water content, it is difficult to obtain shape retention because the viscosity does not increase even if a thickener is added, and the powder component and liquid component can be separated over time. I get up.

In such an oral composition having a low water content, it is difficult to stably mix lactic acid bacteria, and there are also problems such as taste and shape retention. In order to solve these problems, various studies have been conducted so far and various patent documents have been disclosed.

For example, Patent Document 1 (Japanese Patent Application Laid-Open No. 2002-302429) discloses an oral composition in which bitterness and itchiness are alleviated by using sodium bicarbonate in a non-aqueous oral composition base. Yes. In addition, Patent Document 2 (Japanese Patent Laid-Open No. 2002-255572) and Patent Document 3 (Japanese Patent Laid-Open No. 2007-23056) have a shape retention property and high stability by blending specific components. It is disclosed that an oral composition can be obtained. However, the oral compositions disclosed in these publications are not sufficient in taste and shape retention, and are not described at all when they contain lactic acid bacteria. Furthermore, the spinnability, which is important in the use and production stage of the oral composition, has not been clarified.

Patent Document 4 (Japanese Patent Laid-Open No. 2005-298346) discloses a non-aqueous oral composition containing lactic acid bacteria and / or bifidobacteria and hydroxyapatite, and Patent Document 5 (Japanese Patent Laid-Open No. 2007-131601). Non-aqueous oral compositions containing a specific lactic acid bacterium (S.faecalis) have been disclosed, but none of the composition has been clarified about the taste, and the stability of the lactic acid bacterium is unknown.

Thus, as a result of intensive studies to solve the above problems, the present inventors have found that a composition for oral cavity containing 1,3-butylene glycol and hydroxyethyl cellulose can stably stabilize lactic acid bacteria as living bacteria. It has been found that it can be blended and the water content at least improves bitterness and savory taste, and also has shape retention and suitable spinnability. The invention has been completed.
JP 2002-302429 A Japanese Patent Laid-Open No. 2002-255772 JP 2007-023056 A JP 2005-298346 A Japanese Patent Laid-Open No. 2007-131601

The present invention is capable of stably blending lactic acid bacteria in a live state, and at the same time, the water content is at least significantly improved in bitterness and savory taste, and has shape retention and suitable stringiness. An object of the present invention is to provide a composition for an oral cavity that also has a composition.

As a result of intensive studies to solve the above problems, the inventors of the present invention can stably mix lactic acid bacteria as viable bacteria if it is an oral composition containing 1,3-butylene glycol and hydroxyethyl cellulose. It has been found that the water content is at least significantly improved in bitterness and taste, and also has shape retention and suitable spinnability.

The present invention particularly provides the oral composition according to items 1 to 6 below.
Item 1. An oral composition containing lactic acid bacteria, 1,3-butylene glycol and hydroxyethyl cellulose.
Item 2. Furthermore, the composition for oral cavity of Claim 1 containing any 1 type or 2 types of wetting agents chosen from the group which consists of propylene glycol and polyethyleneglycol.
Item 3. The oral composition according to claim 1 or 2, wherein the total amount of 1,3-butylene glycol and propylene glycol and / or polyethylene glycol is 35% by weight or more.
Item 4. The lactic acid bacterium, 1,3-butylene glycol, propylene glycol and hydroxyethyl cellulose are contained, and 1,3-butylene glycol / propylene glycol (weight ratio) is 1 or more, according to any one of claims 1 to 3. Oral composition.
Item 5. The oral composition according to any one of claims 1 to 4, further comprising a sugar alcohol.
Item 6. The oral composition according to any one of claims 1 to 5, further comprising at least one surfactant selected from the group consisting of amino acid surfactants, amide betaines, and alkyl glycosides.

According to the present invention, it is possible to stably mix lactic acid bacteria as living bacteria, and at the same time, the water content is at least greatly improved in bitterness and gummy taste, and the shape retention and suitable silk thread The composition for oral cavity which also has property can be provided.

According to the composition for oral cavity according to the present application, by stably blending lactic acid bacteria, the oral environment (especially the balance of bacteria in the oral flora) is adjusted and adversely affects the human body such as caries-causing bacteria and periodontal disease-causing bacteria. Can be bacteriostatic. In this way, lactic acid bacteria are natural bacteriostatic components that are gentle on the human body with few side effects, and can stably meet the health-consciousness of recent people by blending stably.

In addition, since the composition for oral cavity according to the present application has shape retentivity, it is inconvenient to use as a unit when the used amount is taken out at the time of use, or when placed on a toothbrush. There will be no problems such as sinking in. In addition, the oral composition is used in the oral cavity, and whether the taste is good or bad is an important point for consumers. There is no discomfort. Further, there is no inconvenience due to the stringiness during manufacture and use.

Hereinafter, the present invention will be described in more detail.

The oral composition according to the present invention contains lactic acid bacteria, 1,3-butylene glycol and hydroxyethyl cellulose.

The lactic acid bacterium blended in the oral composition according to the present invention is not particularly limited as long as the effect of the present invention by the lactic acid bacterium can be achieved, but S.faecium, L.reuteri, L.gasseri, L. salivalius, L. mesenteroides, L. brevis, L. acidophilus, L. brugaricus, L. plantarum and S. faecalis are preferred, and among them, S. faecium, L. gasseri, L. mesenteroides, L. brevis L. acidophilus and S. faecalis are preferred. These lactic acid bacteria can be blended alone or in combination of two or more, and the blending amount is preferably 0.0001 to 2.0% by weight, more preferably 0.001 to 1.0% by weight, based on the total composition. In order to achieve the effect, the viable number of lactic acid bacteria to be blended is preferably about 10 ³ to 10 ¹¹ cfu / g, more preferably about 1.0 × 10 ³ to 9.0 × 10 ⁷ cfu / g. preferable.

The amount of 1,3-butylene glycol blended in the oral composition according to the present invention is not particularly limited as long as the effects of the present invention are not impaired, but it is 10 to 80% by weight based on the whole composition. It is preferably 15 to 70% by weight, more preferably 25 to 65% by weight. There are many polyhydric alcohols to be blended in the oral composition other than 1,3-butylene glycol, but 1,3-butylene glycol is optimal for stably blending lactic acid bacteria. It is essential for the composition for oral cavity of the present invention.

The amount of hydroxyethyl cellulose blended in the oral composition according to the present invention is not particularly limited as long as the effects of the present invention are not impaired, but is preferably 0.01 to 5.0% by weight, based on the total composition, 0.1% More preferred is 2.0% by weight. The hydroxyethyl cellulose preferably has a molecular weight of 90000 to 1000000 (low molecular weight) and a polymerization degree of 300 to 2600, more preferably a molecular weight of 90000 to 500000 and a polymerization degree of 300 to 2000. preferable.

In the composition for oral cavity according to the present invention, any one or two kinds of wetting agents selected from the group consisting of propylene glycol and polyethylene glycol can be further blended, and although not particularly limited, propylene glycol is blended. Is more preferable. The amount of these wetting agents is not particularly limited as long as the effects of the present invention are not impaired, but the total amount of 1,3-butylene glycol and propylene glycol and / or polyethylene glycol is based on the whole composition. 35% by weight or more is preferable, and 45% by weight or more is more preferable.

Furthermore, when propylene glycol is blended, 1,3-butylene glycol / propylene glycol (weight ratio) is preferably 1 or more, more preferably 1 to 6.

The composition for oral cavity according to the present invention contains 1,3-butylene glycol and hydroxyethyl cellulose, and even when the water content is low, the bitterness and taste are suppressed. , 3-Butylene glycol, propylene glycol and / or polyethylene glycol are blended in the above blending amount to further improve the taste. In particular, the total amount of 1,3-butylene glycol and propylene glycol and / or polyethylene glycol is preferably 35 to 80% by weight, more preferably 45 to 70% by weight, based on the entire composition. . Furthermore, by adding 1,3-butylene glycol / propylene glycol (weight ratio) in the range of 1 or more, preferably 1 to 10, and more preferably 1 to 6, the taste is further greatly improved. .

In the composition for oral cavity according to the present invention, glycerin may be blended as long as the effects of the present invention are not impaired. Since glycerin has almost no toxicity and exhibits a sweet taste, it is a substance that is preferably blended in the oral composition for improving the taste. However, since it is also a highly viscous substance, care should be taken because the spinnability increases if the amount of glycerin is too large, and the stability of lactic acid bacteria deteriorates if added in large amounts.

As described above, the oral composition according to the present invention has a taste improved by blending a specific amount of 1,3-butylene glycol, hydroxyethyl cellulose, preferably propylene glycol and / or polyethylene glycol. Accordingly, since glycerin is not necessarily added for improving the taste, the amount of glycerin in the oral composition according to the present invention is only an amount required for further taste improvement. preferable. Specifically, it is preferably 3% by weight or less, more preferably 1% by weight or less, and further preferably 0.5% by weight or less, based on the entire composition. Furthermore, it is preferably 10% by weight or less, more preferably 5% by weight or less, still more preferably 1% by weight or less based on the whole wetting agent.

The oral composition according to the present invention may contain a sugar alcohol. Sugar alcohols are blended in general oral compositions as sweeteners and wetting agents, and examples include lactitol, sorbitol, xylitol, erythritol, maltitol, mannitol, and palatinit. Of these, sorbitol and paratinite are particularly preferable. In addition, sugar alcohol can be used 1 type or in combination of 2 or more types. The blending amount of the sugar alcohol is not particularly limited as long as the effects of the present invention are not impaired, but is preferably 0.5 to 5% by weight based on the entire composition. By blending the sugar alcohol, a cooling sensation and sweetness are added to relieve the burning (hot) feeling and bitterness of the oral composition with a low water content, and the feeling of use can be greatly improved.

A surfactant may also be added to the oral composition according to the present invention. Surfactants are generally blended into oral compositions in order to enhance foamability and cleanability. However, since lactic acid bacteria are blended in the composition for oral cavity of the present invention, blending a large amount of a surfactant having a strong surfactant action is not desirable because it adversely affects its survival and deteriorates stability. Accordingly, amino acid surfactants, amide betaines, alkyl glycosides and the like are particularly suitable. Examples of amino acid surfactants include acyl glutamates such as sodium lauroyl glutamate and sodium palmitoyl glutamate, acyl sarcosine salts such as sodium lauroyl sarcosine, acylmethyl taurate, N-lauryl diaminoethyl glycine, and other amino acid surfactants. it can. Examples of amide betaines include coconut oil fatty acid amidopropyldimethylaminoacetic acid betaine (cocoamidopropyl betaine), palm kernel oil fatty acid amidopropyldimethylaminoacetic acid betaine, lauric acid amidopropyldimethylaminoacetic acid betaine, and the like. Of these, coconut oil fatty acid amidopropyldimethylaminoacetic acid betaine (cocoamidopropyl betaine) is more preferred. Examples of the alkyl glycoside include alkyl glucosides having an alkyl chain length of 8 to 16 carbon atoms. In addition, surfactant can be used 1 type or in combination of 2 or more types.

The oral composition according to the present invention is not particularly limited, but can be made into usual dosage forms such as a toothpaste, gel, ointment, pasta, gum and the like according to a conventional method. Among these, a toothpaste and a gel are preferable, and a toothpaste is most preferable.

In the composition for oral cavity according to the present invention, other base components are not particularly limited as long as the effects of the present invention are not impaired, and those usually used for this type of composition can be blended. For example, in the case of toothpaste, abrasives, wetting agents, fragrances, activators, sweeteners, preservatives, colorants, pH adjusters, stabilizers, flavoring agents, astringents, thickeners, other medicinal properties An agent or the like is appropriately blended. In the case of ointment-like preparations, wetting agents, fragrances, active agents, sweeteners, preservatives, colorants, pH adjusters, stabilizers, flavoring agents, astringents, thickeners, other medicinal agents Etc. are appropriately blended.

As abrasives, dicalcium phosphate dihydrate and anhydrous, calcium phosphate, tricalcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, anhydrous silicic acid, silica gel, aluminum silicate, insoluble sodium metaphosphate Tertiary magnesium phosphate, magnesium carbonate, calcium sulfate, polymethyl methacrylate, bentonite, zirconium silicate, hydroxyapatite, synthetic resin, and the like can be used. These abrasives may be used alone or in combination of two or more. The usual blending amount of the abrasive is 5 to 70% by weight, and there is no exception even when the oral composition according to the present invention is used as a toothpaste, but preferably 10 to 60% by weight is blended, and 20 to It is more preferable to blend 50% by weight.

As described above, it is not desirable to add a large amount of a surfactant having a strong surfactant action as described above, since the stability of lactic acid bacteria is deteriorated. Amino acid surfactants, amide betaines, alkylglycosides, etc. are preferably used. Obtained, sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester and lactose fatty acid ester, polyoxyethylene alkyl ethers, fatty acid alkanolamides, polyoxyethylene sorbitan Polyoxyethylene sorbitan fatty acid ester such as monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid ester, polyglycerin fatty acid ester, fatty acid Surfactants such as N-alkyldiaminoethylglycine such as noglyceride, N-lauryldiaminoethylglycine and N-myristyldiethylglycine, N-alkyl-N-carboxymethylammonium betaine, and lauryldimethylaminoacetic acid betaine are also used in the present invention. You may mix | blend if it is a grade which does not impair an effect. These surfactants can be blended singly or in combination of two or more, and the blending amount is preferably 0.01 to 3.0% by weight, more preferably 0.1 to 3.0% by weight.

As the wetting agent, ethanol, glycerin, ethylene glycol, polypropylene glycol, hexylene glycol, or the like can be further used alone or in combination of two or more as long as the effects of the present invention are not impaired.

As fragrances, menthol, anethole, carvone, eugenol, limonene, peppermint oil, spearmint oil, wintergreen, methyl salicylate, cionel, thymol, clove oil, eucalyptus oil, rosemary oil, sage oil, lemon oil, orange oil, ocimen Examples include oil, citronellol, methyl eugenol and the like. These fragrance | flavors can be mix | blended individually or in combination of 2 or more types. The usual blending amount of the fragrance is 0.05 to 5% by weight.

Sweeteners include saccharin sodium, acesulfame potassium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perilartine, thaumatin, asparatylphenylalanyl methyl ester, α-methoxycinnamic aldehyde, xylit, sucralose, palatinose, steviafin, etc. Can be blended. These sweeteners can be blended alone or in combination of two or more. The usual amount of sweetener is 0.005 to 5% by weight, preferably 0.01 to 0.8% by weight.

Examples of the preservative include parabens such as methyl paraben, ethyl paraben, propyl paraben, and butyl paraben, sodium benzoate, phenoxyethanol, and alkyldiaminoethylglycine hydrochloride.

Examples of the colorant include legal pigments such as Blue No. 1, Yellow No. 4, Red No. 202, and Green No. 3, mineral pigments such as ultramarine blue, enhanced ultramarine blue, and bitumen, and titanium oxide.

Examples of the pH adjuster include citric acid, phosphoric acid, malic acid, pyrophosphoric acid, lactic acid, tartaric acid, glycerophosphoric acid, acetic acid, nitric acid, or a chemically possible salt thereof, sodium hydroxide, and the like. The composition can be blended alone or in combination of two or more so that the pH of the composition is in the range of 5-7. The usual amount of the pH adjuster is 0.01 to 2% by weight.

Stabilizers include sodium edetate, sodium thiosulfate, sodium sulfite, sodium chloride, calcium lactate, lanolin, triacetin, castor oil, magnesium sulfate and the like.

Examples of the corrigent include tea extract, tea dry distillation liquid, propolis extract, and sodium glutamate.

Examples of astringents include baking soda and aluminum lactate.

As thickening agents, cellulose derivatives such as hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxymethylethylcellulose, xanthan gum, locust bin gum, carrageenan, tragacanth gum, gums such as karaya gum, gum arabic, gellan gum, polyvinyl alcohol, sodium polyacrylate, carboxy Add synthetic binders such as vinyl polymer and polyvinylpyrrolidone, inorganic binders such as thickening silica, aluminum silica gel, and bee gum, sodium alginate, pectin, agar, gelatin, soybean polysaccharide, sodium chondroitin sulfate, sodium hyaluronate, etc. It is also possible to do. These thickeners can be blended alone or in combination of two or more. The normal blending amount of the thickener is 0.01 to 20% by weight.

Other medicinal agents include: fluorine compounds such as sodium fluoride, sodium monofluorophosphate, stannous fluoride; enzymes such as dextranase, mutanase, amylase, protease, lytic enzyme (Litech Enzyme); tranexamic acid, ε-aminocaproic acid, aluminum chlorohydroxy allantoin, allantoin, dihydrocholesterol, glycyrrhizic acid, glycyrrhetinic acid, bisabolol, isopropylmethylphenol, glycerophosphoric acid, chlorophyll, copper gluconate, sodium chloride, water-soluble inorganic phosphate compound, chlorhexidine salts, triclosan , Cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride; vitamins such as acetic acid-dl-α-tocopherol, pyridoxine acetate, ascorbic acid or salts thereof Aloe, Ginkgo biloba, Agaricus, Oolong tea, Chamomile, Karin, Gymnema, Kumazasa, Tocha tea, Tochu tea, Dokudami, Scallop, Muglinoki, Mugwort, Green tea, Rooibos, Lemon balm, Rosemary, Crabmin, Lacanca, Perilla, Cranberry , Plant extracts such as yarrow, elder, licorice, mint, eucalyptus, guarana, licorice, bodaige, hops, cacao, mulberry leaves, thyme, and ogon. These medicinal agents can be blended alone or in combination of two or more.

As other bases, alcohols, silicon, apatite, white petrolatum, paraffin, liquid paraffin, microcrystalline wax, squalane and the like can be added.

In addition, what is necessary is just to let the compounding quantity of these arbitrary components be the quantity of the grade mix | blended with the normal composition for oral cavity, as long as the effect of this invention is not prevented.

The oral composition according to the present invention is preferably an oral composition having a low water content. If the water content is high, the lactic acid bacteria may be killed in a short period of time, and in this case, it is not possible to maintain the effect throughout the general consumption period of the oral composition. In addition, oral compositions with a low water content often cannot have shape retention even when a thickener is blended, and furthermore, there are many cases where the taste such as bitterness and gummy taste is difficult. However, the composition for oral cavity according to the present invention has at least a water content, good shape retention, and improved bitterness and taste. The oral composition having a low water content preferably has a water content of 0 to 10% by weight, more preferably 0 to 8% by weight, based on the whole oral composition. The water content can be measured by a volumetric titration method described in 2.48 moisture measurement method (Karl Fischer method) of the 15th revision Japanese Pharmacopoeia.

Hereinafter, the present invention will be specifically described, but the present invention is not limited to the following examples. In addition, the compounding quantity in each example shows weight% unless there is particular notice.

<Preparation of composition>
According to a conventional method, each composition (each example and each comparative example) was produced according to the composition described in Table 1, Table 2, and Table 3 below.

<Performance evaluation of composition>
The composition produced in each example was evaluated for bacterial stability, shape retention, stringiness, taste (bitterness, umami), and burning sensation. Examples 1 to 11 and Comparative Examples 1 to 9 were evaluated for fungus stability, shape retention, stringiness, and taste, and Examples 12 to 14 were evaluated for burning feeling, taste, and fungus stability. did.

Stability of bacteria Each composition produced was allowed to stand at 40 ° C., and the number of viable lactic acid bacteria after one month was measured. Specifically, 1 month later, 1 g of the preparation was stirred and diluted in an MRS liquid medium, smeared on the same agar medium, and anaerobically cultured at 37 ° C. for 48 hours, but the number of viable bacteria was counted. The evaluation criteria are as follows.
○: Logarithm of viable cell count less than 1 △: Decrease greater than 1 and less than 2 ×: Decrease greater than 2

Each composition prepared for shape retention was filled into a tube and left at 40 ° C. (high temperature) and 5 ° C. (low temperature) for 1 month. Thereafter, all the tubes were squeezed out, and the shape retention was visually evaluated according to the following criteria. The evaluation criteria are as follows.
○: The squeezed shape is retained for 5 minutes or longer. △: The shape is retained during squeezing, but the shape disappears in less than 5 minutes. ×: There is no shape retention at the time of squeezing.

Takes each composition spinnability produced container, after warming to 25 ° C., from the state immersed the lower half of the metal balls having a diameter of 16mm in the composition, a constant speed (1000 mm / min metal ball ), And measured the distance to rise up to the point when the composition adhering to the metal spheres was cut to evaluate the spinnability. The evaluation criteria are as follows.
○: Very good spinnability (rising distance is less than 36 mm)
Δ: Good spinnability (rising distance is 36 mm or more and less than 40 mm)
×: Poor stringiness (rising distance is 40 mm or more)
-: Unmeasurable

Taste (bitterness, delicious taste)
About 0.5 g of each produced composition was taken in a toothbrush and used in a normal manner, and sensory evaluation was conducted on five expert panelists based on the following evaluation criteria. The evaluation criteria are as follows.
○: No bitterness, no umami taste △: 〃 Somewhat ×: 〃 Very strong

Burning feeling (heat feeling)
About 0.5 g of each produced composition was taken in a toothbrush and used in a normal manner, and sensory evaluation was carried out on five professional panelists based on the following evaluation criteria. The evaluation criteria are as follows.
◎: Feeling no burning at all ○: Feeling little burning △: Feeling a little burning sensation: Feeling a little burning

The table below shows the blending amount at the time of preparing the composition and the results of the performance evaluation of the composition. In addition, the numerical value about the component in a table | surface represents the compounding quantity in weight%. Moreover, comprehensive evaluation was performed by four-step evaluation of x, (triangle | delta), (circle), and (double-circle).

As shown in each example of Table 1 and Table 2, the composition containing 1,3-butylene glycol and hydroxyethyl cellulose has good stability of lactic acid bacteria, shape retention, and good spinnability. It was confirmed that the taste was improved. Among the examples in Table 1, Examples 4 and 5 are excellent in all evaluation items, and the total amount of 1,3-butylene glycol, propylene glycol and / or polyethylene glycol is 45 to 70% by weight, and It was also found that the taste was further improved by blending 1,3-butylene glycol / propylene glycol (weight ratio) in the range of 1-6.

From Table 1 Comparative Example 1 and Table 2 Comparative Examples 8 and 9, it was confirmed that the stability of lactic acid bacteria was very poor in a composition containing a large amount of glycerin.

From Table 1 Comparative Examples 5 to 7, it was confirmed that even when hydroxypropylcellulose, carboxymethylcellulose, and carrageenan were used instead of hydroxyethylcellulose, the shape retention was poor or the spinnability was poor.

Examples 12 to 14 are examples in which sorbitol, palatinit, and glycerin were used to further improve the taste of the oral composition of the present application. As shown in Table 3, the taste and the stability of the bacteria are not good or bad, but for the burning sensation, the composition using sugar alcohol sorbitol and paratinite is more than the composition using glycerin, Greatly improved. From this, it was confirmed that among the substances used to improve the taste, sugar alcohol can greatly improve the burning sensation of the oral composition according to the present application.

Hereinafter, formulation examples of the oral composition according to the present invention will be described.

Claims

An oral composition containing lactic acid bacteria, 1,3-butylene glycol and hydroxyethyl cellulose.
Furthermore, the composition for oral cavity of Claim 1 containing any 1 type or 2 types of wetting agents chosen from the group which consists of propylene glycol and polyethyleneglycol.
The oral composition according to claim 2, wherein the total amount of 1,3-butylene glycol and propylene glycol and / or polyethylene glycol is 35% by weight or more.
The composition for oral cavity according to claim 1, comprising lactic acid bacteria, 1,3-butylene glycol, propylene glycol and hydroxyethyl cellulose, wherein 1,3-butylene glycol / propylene glycol (weight ratio) is 1 or more.
Furthermore, the composition for oral cavity of Claim 1 containing sugar alcohol.
Furthermore, the composition for oral cavity of Claim 1 containing the at least 1 sort (s) of surfactant selected from the group which consists of an amino acid type surfactant, an amide betaine, and an alkyl glycoside.