JPH10236934A - Oral composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an oral composition excellent in low temperature stability, oral dispersion and feeling in use, and useful as a mouth-washing agent, a dentifrice gent, etc., by compounding a native gellan gum. SOLUTION: This composition is composed of a native gellan gum, i.e., a microorganism produced polysaccharide. A low viscosity liquid oral composition such as a mouth-washing agent, a high viscosity liquid, a pasty or a powdery oral composition such as a dentifrice composition can be produced by compounding the native gellan gum at 0.005-10wt.% of the total composition. The mouth-washing agent preferably has a viscosity of 1-500Pas at 25 deg.C and the compounding ratio of 0.05-0.6wt.% of the native gellan gum, and the dentifrice composition preferably has the compounding ratio of the native gellan gum of 0.05-3wt.%. Thus obtained mouth-washing composition can hold homogeneous stability in low-temperature storage, and has no stickiness and foreign taste. The obtained dentifrice composition is good in oral dispersion, little in stickiness, excellent in rinse after teeth brushing and god in shape-retainability on a toothbrush.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to oral compositions such as mouth washes, dentifrices and the like.

[0002]

2. Description of the Related Art Brushing with a dentifrice or mouthwash with a mouthwash has been conventionally performed in order to remove plaque which is a cause of dental caries or periodontal disease.

[0003] Generally, a mouthwash is an aqueous liquid composition containing water, a wetting agent, a surfactant, a medicinal component, a fragrance, a flavoring agent, a pH adjuster and the like.

However, since the liquid contains a large amount of water, it freezes temporarily when stored at a low temperature below the freezing point, especially in winter, so that when it is returned to normal temperature, phase separation, suspended matter such as dust, sedimentation occurs. In some cases, it may be difficult to ensure uniform stability of the contents.

[0005] Therefore, in order to prevent the preparation from freezing and increasing the viscosity during storage at low temperatures, a humectant such as alcohol, glycerin, sugar alcohol, propylene glycol or polyethylene glycol has conventionally been added. Oral composition containing cosinate and eicosenol and / or docosenol (Japanese Unexamined Patent Publication No. 8-26
No. 8852), a specific amount of ethanol and a wetting agent
Liquid oral composition containing -menthol and N-substituted-p-menthan-3-carboxamides (Japanese Patent Application Laid-Open No. 8-28)
No. 3132) has been proposed.

As a means for improving the uniform stability during low-temperature storage, a liquid transparent oral composition comprising a combination of a perfume and a polyoxyethylene-polyoxypropylene block polymerization type nonionic surfactant and a paraoxybenzoate ester is used. (JP-A-8-159212), an oral composition containing an alkyl sulfate, an N-acylmethyltaurine salt and polyethylene glycol (JP-A-8-17)
No. 5944), but these substances have unique sweetness, bitterness, heat, irritation, etc.
It is difficult to formulate an effective amount due to usability issues,
There has been a demand for a method that is more effective and has excellent usability.

On the other hand, a dentifrice composition, in particular, a paste dentifrice, a liquid dentifrice, and a wet powder dentifrice contain a binder for the purpose of stabilizing the dispersion of the abrasive and ensuring wettability. ing. As the binder, a water-soluble polymer such as carboxymethylcellulose (CMC), sodium alginate, xanthan gum, carrageenan, sodium polyacrylate and the like are generally used.

However, dentifrices containing these binders have poor dispersibility in the mouth, cause a feeling of stickiness, and deteriorate the feeling of use such as poor rinsing after dentifrice.

Therefore, in order to improve these usability,
Proposals have been made to adjust the viscosity to 20 to 180 poise / 25 ° C. and to use a crosslinked polyacrylate and xanthan gum as a binder in Japanese Patent Application Laid-Open Nos. 61-15826 and 4-210.
No. 908, No. 4-217614, No. 4-217615
It is proposed in Japanese Patent Publication No.

However, these dentifrices do not sufficiently improve the feeling of use, and furthermore, because of their low viscosity and poor shape retention, the rate of penetration into the toothbrush is high, and the amount used is unclear. There was a drawback in use that it would drip. Therefore, there has been a demand for a method for more effectively and surely remedying the above-mentioned drawbacks.

The present invention has been made to meet the above-mentioned demands, and has as its object to provide a composition for oral cavity which is excellent in low-temperature stability, dispersibility in mouth, and feeling upon use.

[0012]

Means for Solving the Problems and Embodiments of the Invention As a result of intensive studies to achieve the above object, the present inventors have added native gellan gum, which is a polysaccharide produced by microorganisms, to an oral composition. As a result, it was found that an oral composition having excellent low-temperature stability, dispersibility in the mouth, and feeling in use can be obtained.

That is, this native gellan gum is a substance having a different chemical structure and physical properties from gellan gum as described later. In this case, gellan gum has been conventionally used in foods as a gelling agent, and as for blending into an oral composition, furanone,
an oral composition for inhibiting and removing decay of dental caries (JP-A-5-139797), which contains a polysaccharide selected from ι-carrageenan, furceleran and gellan gum as an active ingredient; gellan gum and a nonionic surfactant; An oral liquid composition (JP-A-8-3074) having excellent blending safety of gellan gum and excellent retention of a medicinal ingredient in the oral cavity, and a mouthwash composition containing gellan gum and an abrasive (Japanese Patent Application No. Hei 10-301). No. 7-171524) has been proposed.

[0014] In addition, the dentifrice composition contains anhydrous dentifrice containing glycerin in an amount of 50% by weight or more (Japanese Patent Publication No.
JP-A-88894), 5 to 50% of an abrasive in an aqueous medium
A blended dentifrice composition (Japanese Patent Application No. Hei 7-171523) has been proposed.

However, according to the study of the present inventors, when gellan gum is added to a mouthwash, as shown in the results of comparative examples described later, the low-temperature stability is inferior, and the feeling of use such as stickiness and taste is low. This is still not satisfactory in terms of the above-mentioned point, and when it is blended in a dentifrice, it is unsatisfactory in terms of shape retention and the like.

However, by blending the native gellan gum into the mouthwash composition, there is no phase separation of the preparation and no formation of insoluble substances such as crystals, scum and the like even during storage at low temperature.
That uniform stability is maintained, and that a mouthwash composition having an excellent feeling of use without stickiness or off-taste can be obtained,
In the dentifrice composition, dispersibility in the mouth is good,
It has been found that a dentifrice composition with less fluffiness, excellent sensation of good rinsing after dentifrice, excellent expression of spinnability, and excellent operability with good shape retention on a toothbrush can be obtained. .

As described above, there is no example in which native gellan gum is blended in an oral composition, and it is a new finding of the present inventors that blending native gellan gum in an oral composition, thereby obtaining the above-mentioned excellent effects. It is.

Further, although the mouthwash is simple, it is extremely low in viscosity, so that it is difficult to obtain a necessary and sufficient feeling of cleaning at the time of mouthwashing. Has a drawback that the retention property is weak. As means for solving the above-mentioned problems, a specific water-soluble polymer consisting of one or more of xanthan gum, carrageenan, sodium carboxymethylcellulose, and sodium alginate has already been added to the mouthwash composition to enhance the retention. Proposal has also been made to give a feeling of use called thickening (Japanese Patent Application Laid-Open No. 8-333227). However, when the amount of native gellan gum is increased, the stickiness and the stickiness are less than those of these water-soluble polymers. The present inventors have also found out that a natural gellan gum can provide excellent characteristics as a compounding component of an oral composition, as well as being able to impart an excellent smooth thick feeling.

Hereinafter, the present invention will be described in more detail. The composition for oral cavity of the present invention contains native gellan gum.

Here, the native gellan gum used in the present invention is also referred to as a high acetyl group gellan gum, and retains the structure of the gellan gum immediately after fermentation and production by the microorganism Pseudomonas elodea. A high-molecular-weight polysaccharide consisting of glucuronic acid, glucose, and rhamnose repeated from four saccharides, in which an acetyl group (C ₆ position) and a glyceryl group (C ₂ position) are bound to a part of glucose. . The glyceryl group has one residue and the acetyl group has one-half residue in the repeating unit, and is sold by Monsanto under the name of Kelcogel LT-100.

That is, this native gellan gum is a substance obtained during the production process of gellan gum, and has a different molecular structure from gellan gum. In other words, gellan gum consists of repetition from glucose, glucuronic acid, glucose, and rhamnose, after fermentative production by the microorganism Pseudomonas elodea, removing acetyl and glyceryl groups bonded to glucose residues by a deacylation step. In contrast, native gellan gum retains the structure of gellan gum immediately after it is produced by fermentation, and is a high-molecular polysaccharide in which acetyl and glyceryl groups are bonded to part of glucose. It is.

In the state of an aqueous solution, gellan gum forms a hard and brittle gel in the presence of metal ions, particularly calcium ions, and the strength of the gel is easily affected by the ion concentration and pH. Native gellan gum is less affected by metal ions and pH and builds a soft and elastic gel.

The amount of the above-mentioned native gellan gum is as follows:
It is appropriately selected depending on the type of the oral composition and the like, and is usually in the range of 0.005 to 10% (% by weight, hereinafter the same) of the whole composition.

The oral composition of the present invention is prepared in the form of a low-viscosity liquid oral composition such as a mouthwash composition and a high-viscosity liquid, paste-like or powdery oral composition such as a dentifrice composition. obtain.

Here, the low-viscosity liquid composition refers to a composition having a viscosity at 25 ° C. of 1 to 1800 mPas, and a composition exceeding the viscosity is referred to as a high-viscosity liquid or paste.

When the low-viscosity liquid mouthwash composition is prepared according to the present invention, its viscosity is 1 to 1800 mPas at 25 ° C. as described above, and more preferably 1 to 1800 mPas.
1000 mPas, and more preferably 1 to 500 mPas, from the viewpoint of fluidity, usability, and feeling of use.

In this case, the amount of native gellan gum added to the mouthwash composition is 0.005 to 0.005% of the whole composition.
1%, especially 0.01-0.8%, especially 0.05-
If the content is less than 0.005%, low-temperature stabilization may not be obtained, and if it exceeds 1%, the fluidity may be impaired due to gelation. An excellent low-temperature stability effect can be obtained by blending native gellan gum, but even if gellan gum is used, the gel structure is completely destroyed by freezing to thawing, so that the low-temperature stability effect as described above cannot be obtained.

As the mouthwash composition, components that can be used in ordinary mouthwash compositions can be used. Specifically, ethanol, glycerin, sorbit, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactitol, etc. (usually 2 to 70%) as wetting agents, As a dispersant, sodium alginate, carrageenan, sodium carboxymethylcellulose, methylcellulose, cellulose derivatives such as hydroxyethylcellulose, gum tragacanth, gum karaya, gum arabic, xanthan gum, gellan gum, etc., sodium polyacrylate, polyvinyl alcohol, carboxyvinyl polymer, polyvinylpyrrolidone And synthetic water-soluble polymers such as silica gel, aluminum silica gel, veegum, laponite, etc. Dispersants (usually in an amount of 0.005 to 1%), anionic surfactants such as sodium lauryl sulfate, sodium myristyl sulfate, N-lauroyl sarcosinate, and lauroyl methyl taurine; Monoglycerin stearate, decaglyceryl laurate, diethanolamide myristic acid,
Nonionic surfactants such as polyoxyethylene hydrogenated castor oil and polyoxyethylene polyoxypropylene glycol (usually in an amount of 0.05 to 3%), sodium fluoride, sodium monofluorophosphate, Fluorine compounds such as monotin, dextranase, mutanase, protease, enzymes such as lysozyme, tranexamic acid, ε-aminocaproic acid, aluminum chlorohydroxyallantoin, dihydrocholestanol, glycyrrhizic acids, bisabolol, isopropylmethylphenol, glycerophosphate, Chlorophyll, copper gluconate, sodium chloride, water-soluble inorganic phosphate compound,
Chlorhexidine salts, triclosan, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, cloves, rosemary, thyme, plant extracts such as pentagon, etc., saccharin sodium, stevioside, glycyrrhizin, asparatyl phenylalanine methyl ester, menthol, anethole as a flavoring agent Red 3 as a colorant such as, carvone, eugenol, limonene, peppermint, spearmint, wintergreen, etc.
No., Red No. 105, Red No. 106, Yellow No. 4, Blue No. 1
No. 2, Blue No. 2, Green No. 3 and the like.

Further, as a cleaning aid at the time of mouth washing, precipitated silica, zirconosilicate, aluminosilicate, calcium phosphate, calcium carbonate, aluminum hydroxide,
A polishing agent such as aluminum oxide can also be blended (usually in a blending amount of 2 to 30%). In addition, the compounding amount of these optional components can be a normal amount as long as the effect of the present invention is not hindered.

When a high-viscosity liquid, paste-like or powdery composition such as a dentifrice composition is obtained, the amount of native gellan gum is 0.01 to 10%, preferably 0.03 to 5% of the total composition. In particular, the content is preferably set to 0.05 to 3%. If the content is less than 0.01%, the dispersion stabilization of the abrasive or the like may not be obtained. , The feeling of use may be impaired.

When the dentifrice composition is prepared, the abrasive used is not particularly limited as long as it is a dentally acceptable water-insoluble abrasive. For example, silica-based abrasives such as precipitated silica and zirconosilicate are used. Agents, calcium carbonate, calcium phosphate, calcium pyrophosphate, magnesium carbonate, insoluble sodium metaphosphate, aluminum hydroxide, aluminum oxide, titanium oxide, mica titanium, zeolite, smectite, crystalline cellulose, crystalline pulp and the like. Two or more can be used in combination.

The compounding amount of the abrasive is from 3 to 80 of the whole composition.
%, Preferably 5 to 60%, particularly preferably 5 to 50%. If the compounding amount of the abrasive is less than 3%, sufficient cleaning power cannot be obtained, and if it exceeds 80%, the polishing power becomes high and harmfulness to teeth may be exhibited.

In the present invention, in addition to native gellan gum, if necessary, other binders can be blended as long as the effects of the present invention are not impaired. Examples of such a binder include carrageenan, sodium alginate, sodium carboxymethylcellulose, methyl cellulose, cellulose derivatives such as hydroxyethyl cellulose, gum tragacanth, gum karaya, gum arabic, xanthan gum, gum gellan and the like, sodium polyacrylate, polyvinyl alcohol , A carboxyvinyl polymer, a synthetic binder such as polyvinylpyrrolidone, and an inorganic binder such as silica gel, aluminum silica gel, veegum, and laponite. One or more of these may be blended. The amount of these other binders is not particularly limited, but is preferably 5% or less, particularly preferably 3% or less.

In the dentifrice composition of the present invention, in addition to the above-mentioned essential components, optional components that can be used in ordinary dentifrice compositions can be used.

For example, as a wetting agent, ethanol, glycerin, sorbit, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactitol, etc. (usually in an amount of 5 to 8)
0%), anionic surfactants such as sodium lauryl sulfate, sodium myristyl sulfate, N-lauroyl sarcosinate, lauroylmethyltaurine, sucrose fatty acid ester, monoglycerin stearate, decaglyceryl laurate, myristin Nonionic surfactants such as acid diethanolamide, polyoxyethylene hydrogenated castor oil, and polyoxyethylene polyoxypropylene glycol can be blended (usually in a blending amount of 0.05 to 5%), as well as active ingredients, flavors, and coloring. The above-exemplified agents and the like can be blended in a usual amount as long as the effects of the present invention are not impaired.

[0036]

The oral composition of the present invention has low-temperature stability,
It has good dispersibility and usability.

[0037]

EXAMPLES The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to the following examples. In addition, all% in each example are weight%.

[Examples and Comparative Examples A] Mouthwash compositions having the compositions shown in Tables 1 to 6 were prepared by a conventional method, and the low-temperature stability and usability were evaluated by the following methods. The results are shown in Tables 1 to 6.

(1) Low-temperature stability 80 ml of each mouthwash was placed in a 100-ml PET bottle, stored in a constant temperature bath at -5 ° C., and the appearance after three months was visually judged according to the following criteria. . -Evaluation criteria 基準: No generation of suspended matter or precipitate, turbidity, phase separation, and no change in appearance were observed (pass). Δ: No phase separation, but slight turbidity, suspended matter, and formation of sediment are observed (pass). ×: Phase separation has occurred. Alternatively, formation of turbidity, suspended matter, or precipitate is observed (fail). (2) Feeling of Use Eight panelists included 10 ml of each mouthwash in their mouth, and after mouthwashing for 20 seconds, the feeling of use was evaluated in terms of spitting, stickiness and taste according to the following criteria. -Evaluation criteria of stickiness ○: No unpleasant stickiness and no stickiness in the mouth (pass). Δ: Slight stickiness or stickiness was felt in the mouth, but not uncomfortable (pass). ×: Unpleasant stickiness and stickiness remain in the mouth (fail).・ Taste evaluation criteria ○: No unpleasant taste, irritation or discomfort during mouth washing (pass). X: Unpleasant taste, irritation, or discomfort during mouth washing (fail).

[0040]

[Table 1]

[0041]

[Table 2]

[0042]

[Table 3]

[0043]

[Table 4]

[0044]

[Table 5]

[0045]

[Table 6]

From the results shown in Tables 1 to 6, it was confirmed that the mouthwash composition of the present invention containing native gellan gum was excellent in low-temperature stability and feeling upon use.

[Examples and Comparative Example B] Toothpastes having the compositions shown in Tables 7 and 8 and liquid and wet powdered toothpastes having the compositions shown in Tables 10 and 11 were prepared and dispersible in the mouth by the following method. The evaluation was conducted on the evaluation of the following formulas: skin stickiness, rinsing after tooth brushing, spinnability of the preparation, shape retention on a toothbrush, and comprehensive judgment. Tables 9 and 12 show the results.
Shown in

(1) Dispersibility in the mouth, stickiness When 1 g of a sample was brushed with a toothbrush, the dispersibility in the mouth was sensory evaluated according to the following criteria. -Evaluation criteria 3 points: Dispersed in the mouth immediately after brushing, good without stickiness (pass). 2 points: Slightly sticky, but disperses after a while (pass). 1 point: sticky and difficult to disperse in mouth (fail). (2) Rinsing after tooth brushing 1 g of a sample was taken with a toothbrush and brushed for 1 minute, and then a mouthwash for 2 seconds with 15 g of water was repeated 5 times. The turbidity of the discharged liquid was visually observed five times, and the rinsing was sensory-evaluated according to the following criteria. Evaluation criteria 3 points: The dentifrice was not mixed from the second and third discharges and became transparent (the rinse-off was good: passed). 2 points: From the 4th to 5th discharges, dentifrice is not mixed and becomes transparent (rinsing is slightly good: pass). 1 point: The 5th discharge was also cloudy with the dentifrice (poor rinsing: failed). (3) Spinnability measuring device: RHEO METER CR-200D (SU
Speed: 300 mm / min. The sample was immersed in the upper part of the plunger, and the length of the drawn yarn when the sample was pulled up at the above speed was measured and evaluated according to the following criteria. -Evaluation criteria 3 points: Less than 20 mm (pass). 2 points: 20 mm or more and less than 30 mm (pass). 1 point: 30 mm or more (fail). (4) Shape retention to toothbrush Plastic bottle filled with sample (2 m inside diameter)
extrude the sample from m) and place sample 1 on the toothbrush
g was placed thereon, and after 5 seconds, the shape retention on the toothbrush was sensory evaluated according to the following criteria. In this case, the following toothbrush was used. Flocked part: 8.8 mm x 26.8 mm (width x height) Number of flocked holes: 3 holes x 1 row + 4 holes x 9 rows = 39 holes Number of flocked: 20 / hole Hair length: 10.5 mm-Evaluation Criteria 3 points: The sample does not penetrate into the hair of the toothbrush (pass). 2 points: The sample slightly permeates the hair of the toothbrush (pass). 1 point: The sample soaks into the bristles of the toothbrush (fail). (5) Comprehensive Judgment A composition that satisfies all of the properties of dispersibility in the mouth, rinsing, spinnability, and shape retention to toothbrush is judged to be acceptable.
It was represented by a circle. Of these, particularly excellent compositions are indicated by ◎ and distinguished from other compositions. If even one property was unsatisfactory, it was rejected and indicated by a cross.

[0049]

[Table 7]

[0050]

[Table 8]

[0051]

[Table 9]

[0052]

[Table 10]

[0053]

[Table 11]

[0054]

[Table 12]

From the results shown in Tables 9 and 12, the dentifrice composition of the present invention containing native gellan gum has a good dispersibility in the mouth,
It was confirmed that it was excellent in rinsing, spinnability, and shape retention to a toothbrush.

Example 30 Oral Ointment (Cream) Native Gellan Gum 0.8% Glycerin 23.0 Ethanol 7.0 Cetylpyridinium Chloride 0.05 Dipotassium Glycyrrhizinate 0.5 Allantoin 0.3 Hinokitiol 0.1 Mono Polyoxyethylene sorbitan stearate 0.1 Sorbitan monostearate 0.1 Light liquid paraffin 0.5 Sodium hydroxide 0.2 Fragrance 1.0 Purified water Balance meter 100.0%

Example 31 Mouth Coolant (Gel) Native Gellan Gum 0.3% Ethanol 20.0 Glycerin 7.5 Polyoxyethylene (60) Hardened Castor Oil 1.5 Saccharin 0.1 Perfume 1.5 Purification Water balance meter 100.0%

 ────────────────────────────────────────────────── ─── Continuing on the front page (72) Inventor Teruo Horiuchi 1-3-7 Honjo, Sumida-ku, Tokyo Inside Lion Corporation

Claims (1)

[Claims] An oral composition containing native gellan gum.