JP4841146B2 - Plaque staining composition - Google Patents
Plaque staining composition Download PDFInfo
- Publication number
- JP4841146B2 JP4841146B2 JP2005047348A JP2005047348A JP4841146B2 JP 4841146 B2 JP4841146 B2 JP 4841146B2 JP 2005047348 A JP2005047348 A JP 2005047348A JP 2005047348 A JP2005047348 A JP 2005047348A JP 4841146 B2 JP4841146 B2 JP 4841146B2
- Authority
- JP
- Japan
- Prior art keywords
- plaque
- staining
- composition
- mass
- staining composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000010186 staining Methods 0.000 title claims description 74
- 239000000203 mixture Substances 0.000 title claims description 69
- -1 polyoxyethylene Polymers 0.000 claims description 36
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 21
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 14
- 239000003205 fragrance Substances 0.000 claims description 14
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 14
- 239000000811 xylitol Substances 0.000 claims description 14
- 235000010447 xylitol Nutrition 0.000 claims description 14
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 14
- 229960002675 xylitol Drugs 0.000 claims description 14
- 239000004359 castor oil Substances 0.000 claims description 11
- 235000019438 castor oil Nutrition 0.000 claims description 11
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 11
- 239000000049 pigment Substances 0.000 claims description 10
- 239000004094 surface-active agent Substances 0.000 claims description 10
- 235000015110 jellies Nutrition 0.000 claims description 5
- 239000008274 jelly Substances 0.000 claims description 5
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 claims description 2
- QDLAGTHXVHQKRE-UHFFFAOYSA-N lichenxanthone Natural products COC1=CC(O)=C2C(=O)C3=C(C)C=C(OC)C=C3OC2=C1 QDLAGTHXVHQKRE-UHFFFAOYSA-N 0.000 claims description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 22
- 239000000796 flavoring agent Substances 0.000 description 12
- 235000019634 flavors Nutrition 0.000 description 12
- 235000011187 glycerol Nutrition 0.000 description 12
- 239000007788 liquid Substances 0.000 description 12
- 239000002552 dosage form Substances 0.000 description 11
- 239000002775 capsule Substances 0.000 description 9
- 235000014113 dietary fatty acids Nutrition 0.000 description 8
- 239000000194 fatty acid Substances 0.000 description 8
- 229930195729 fatty acid Natural products 0.000 description 8
- UBVSIAHUTXHQTD-UHFFFAOYSA-N 2-n-(4-bromophenyl)-1,3,5-triazine-2,4-diamine Chemical compound NC1=NC=NC(NC=2C=CC(Br)=CC=2)=N1 UBVSIAHUTXHQTD-UHFFFAOYSA-N 0.000 description 6
- 108010010803 Gelatin Proteins 0.000 description 6
- 239000011230 binding agent Substances 0.000 description 6
- 235000012732 erythrosine Nutrition 0.000 description 6
- 239000008273 gelatin Substances 0.000 description 6
- 229920000159 gelatin Polymers 0.000 description 6
- 235000019322 gelatine Nutrition 0.000 description 6
- 235000011852 gelatine desserts Nutrition 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 239000011248 coating agent Substances 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 210000004195 gingiva Anatomy 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 4
- 108010035532 Collagen Proteins 0.000 description 4
- 229920002307 Dextran Polymers 0.000 description 4
- 239000008272 agar Substances 0.000 description 4
- 235000010419 agar Nutrition 0.000 description 4
- 235000010443 alginic acid Nutrition 0.000 description 4
- 229920000615 alginic acid Polymers 0.000 description 4
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 4
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 229920001436 collagen Polymers 0.000 description 4
- 235000003599 food sweetener Nutrition 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 210000004379 membrane Anatomy 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000006072 paste Substances 0.000 description 4
- 239000003765 sweetening agent Substances 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000000080 wetting agent Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 208000002064 Dental Plaque Diseases 0.000 description 3
- 235000016623 Fragaria vesca Nutrition 0.000 description 3
- 240000009088 Fragaria x ananassa Species 0.000 description 3
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 150000005215 alkyl ethers Chemical class 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 229920000609 methyl cellulose Polymers 0.000 description 3
- 239000001923 methylcellulose Substances 0.000 description 3
- 235000010981 methylcellulose Nutrition 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- AZJPTIGZZTZIDR-UHFFFAOYSA-L rose bengal Chemical compound [K+].[K+].[O-]C(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 AZJPTIGZZTZIDR-UHFFFAOYSA-L 0.000 description 3
- 239000007901 soft capsule Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 229920001285 xanthan gum Polymers 0.000 description 3
- 235000010493 xanthan gum Nutrition 0.000 description 3
- 239000000230 xanthan gum Substances 0.000 description 3
- 229940082509 xanthan gum Drugs 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 2
- 244000215068 Acacia senegal Species 0.000 description 2
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- 229920002148 Gellan gum Polymers 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 2
- 208000025157 Oral disease Diseases 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229920001214 Polysorbate 60 Polymers 0.000 description 2
- 239000004373 Pullulan Substances 0.000 description 2
- 229920001218 Pullulan Polymers 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 239000004376 Sucralose Substances 0.000 description 2
- 229920001615 Tragacanth Polymers 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 239000000205 acacia gum Substances 0.000 description 2
- 235000010358 acesulfame potassium Nutrition 0.000 description 2
- 229960004998 acesulfame potassium Drugs 0.000 description 2
- 239000000619 acesulfame-K Substances 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 229940072056 alginate Drugs 0.000 description 2
- 239000000305 astragalus gummifer gum Substances 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 239000000551 dentifrice Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000004043 dyeing Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 235000010492 gellan gum Nutrition 0.000 description 2
- 239000000216 gellan gum Substances 0.000 description 2
- 239000003349 gelling agent Substances 0.000 description 2
- 229920000591 gum Polymers 0.000 description 2
- 239000007902 hard capsule Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 210000000088 lip Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 208000030194 mouth disease Diseases 0.000 description 2
- 210000002200 mouth mucosa Anatomy 0.000 description 2
- 239000007968 orange flavor Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 235000019423 pullulan Nutrition 0.000 description 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 2
- 239000004299 sodium benzoate Substances 0.000 description 2
- 235000010234 sodium benzoate Nutrition 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 235000019408 sucralose Nutrition 0.000 description 2
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 1
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 1
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 description 1
- QYIXCDOBOSTCEI-QCYZZNICSA-N (5alpha)-cholestan-3beta-ol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 QYIXCDOBOSTCEI-QCYZZNICSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- LQXBZWFNAKZUNM-UHFFFAOYSA-N 16-methyl-1-(16-methylheptadecoxy)heptadecane Chemical compound CC(C)CCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC(C)C LQXBZWFNAKZUNM-UHFFFAOYSA-N 0.000 description 1
- WFIYPADYPQQLNN-UHFFFAOYSA-N 2-[2-(4-bromopyrazol-1-yl)ethyl]isoindole-1,3-dione Chemical compound C1=C(Br)C=NN1CCN1C(=O)C2=CC=CC=C2C1=O WFIYPADYPQQLNN-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- SATHPVQTSSUFFW-UHFFFAOYSA-N 4-[6-[(3,5-dihydroxy-4-methoxyoxan-2-yl)oxymethyl]-3,5-dihydroxy-4-methoxyoxan-2-yl]oxy-2-(hydroxymethyl)-6-methyloxane-3,5-diol Chemical compound OC1C(OC)C(O)COC1OCC1C(O)C(OC)C(O)C(OC2C(C(CO)OC(C)C2O)O)O1 SATHPVQTSSUFFW-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 239000001904 Arabinogalactan Substances 0.000 description 1
- 229920000189 Arabinogalactan Polymers 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- 241000589151 Azotobacter Species 0.000 description 1
- 239000001884 Cassia gum Substances 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical class C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 229920002558 Curdlan Polymers 0.000 description 1
- 239000001879 Curdlan Substances 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229920002581 Glucomannan Polymers 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 240000008790 Musa x paradisiaca Species 0.000 description 1
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 241000934878 Sterculia Species 0.000 description 1
- 244000228451 Stevia rebaudiana Species 0.000 description 1
- 235000004298 Tamarindus indica Nutrition 0.000 description 1
- 240000004584 Tamarindus indica Species 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 150000003973 alkyl amines Chemical class 0.000 description 1
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 1
- QYIXCDOBOSTCEI-UHFFFAOYSA-N alpha-cholestanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 QYIXCDOBOSTCEI-UHFFFAOYSA-N 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 235000019312 arabinogalactan Nutrition 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 229940036350 bisabolol Drugs 0.000 description 1
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 1
- DBZJJPROPLPMSN-UHFFFAOYSA-N bromoeosin Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C(O)C(Br)=C1OC1=C(Br)C(O)=C(Br)C=C21 DBZJJPROPLPMSN-UHFFFAOYSA-N 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 235000019318 cassia gum Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 229940099898 chlorophyllin Drugs 0.000 description 1
- 235000019805 chlorophyllin Nutrition 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 229940108928 copper Drugs 0.000 description 1
- 235000019316 curdlan Nutrition 0.000 description 1
- 229940078035 curdlan Drugs 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- MQWPIYMKAKYEEQ-UHFFFAOYSA-L dipotassium 2,3,4,5-tetrachloro-6-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate Chemical compound [K+].[K+].[O-]C(=O)c1c(Cl)c(Cl)c(Cl)c(Cl)c1-c1c2cc(Br)c([O-])c(Br)c2oc2c(Br)c(=O)c(Br)cc12 MQWPIYMKAKYEEQ-UHFFFAOYSA-L 0.000 description 1
- GZAAPEKTGHKWRZ-UHFFFAOYSA-L dipotassium;2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate Chemical compound [K+].[K+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 GZAAPEKTGHKWRZ-UHFFFAOYSA-L 0.000 description 1
- VQHHOXOLUXRQFQ-UHFFFAOYSA-L dipotassium;4,5,6,7-tetrachloro-2',4',5',7'-tetraiodo-3-oxospiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate Chemical compound [K+].[K+].O1C(=O)C(C(=C(Cl)C(Cl)=C2Cl)Cl)=C2C21C1=CC(I)=C([O-])C(I)=C1OC1=C(I)C([O-])=C(I)C=C21 VQHHOXOLUXRQFQ-UHFFFAOYSA-L 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000008369 fruit flavor Substances 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 229940046240 glucomannan Drugs 0.000 description 1
- 229940074774 glycyrrhizinate Drugs 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 239000000231 karaya gum Substances 0.000 description 1
- 229940039371 karaya gum Drugs 0.000 description 1
- SXQCTESRRZBPHJ-UHFFFAOYSA-M lissamine rhodamine Chemical compound [Na+].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=C(S([O-])(=O)=O)C=C1S([O-])(=O)=O SXQCTESRRZBPHJ-UHFFFAOYSA-M 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- VFRPYBIGSSNAJS-UHFFFAOYSA-N methyl 2-benzoyloxybenzoate Chemical compound COC(=O)C1=CC=CC=C1OC(=O)C1=CC=CC=C1 VFRPYBIGSSNAJS-UHFFFAOYSA-N 0.000 description 1
- 229960002900 methylcellulose Drugs 0.000 description 1
- 239000008368 mint flavor Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 231100000017 mucous membrane irritation Toxicity 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 229960004172 pyridoxine hydrochloride Drugs 0.000 description 1
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
- 239000011764 pyridoxine hydrochloride Substances 0.000 description 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- VIZXMHCBZLGUET-UHFFFAOYSA-N sodium gualenate Chemical compound CC(C)C1=CC=C(C)C2=C(S(O)(=O)=O)C=C(C)C2=C1 VIZXMHCBZLGUET-UHFFFAOYSA-N 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 235000010491 tara gum Nutrition 0.000 description 1
- 239000000213 tara gum Substances 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000001018 xanthene dye Substances 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Description
本発明は、歯垢を視覚的に検出することができる歯垢染色用組成物に関する。 The present invention relates to a plaque staining composition capable of visually detecting plaque.
歯垢は歯面に形成される軟らかい非石灰性の細菌性沈着物であって、歯肉炎やう蝕などの口腔疾患の主原因である。従って、この歯垢を取り除くことがこれらの口腔疾患の予防において重要である。しかしながら、通常の口腔内の清掃手段において完全に除去されているか否かを判断するのは困難であるために、歯垢を容易に検出する手段が必要となる。その手段として、従来、種々の染料により歯垢を染色して歯面に付着する歯垢を検出する方法が行われている。
しかしながら、従来の染料やヨウ素などの染色剤を用いた歯垢染色用組成物は、歯垢を染色するのみならず、歯肉及び唇などにも長時間、強く染色するために、使用する際に不快感がある。また特に、ヨウ素を用いた歯垢染色用組成物の場合は、使用時の不快味や粘膜刺激性が強く、使用に際して問題があった。
Plaque is a soft, non-calcifying bacterial deposit that forms on the tooth surface and is the main cause of oral diseases such as gingivitis and caries. Therefore, removing this plaque is important in preventing these oral diseases. However, since it is difficult to determine whether or not it has been completely removed by a normal intraoral cleaning means, a means for easily detecting plaque is required. Conventionally, a method for detecting plaque adhering to the tooth surface by staining plaque with various dyes has been used.
However, the composition for staining plaque using a conventional dye or a staining agent such as iodine not only stains plaque but also strongly stains gums and lips for a long time. There is discomfort. In particular, in the case of a composition for staining plaque using iodine, the unpleasant taste and mucous membrane irritation at the time of use are strong, and there has been a problem in use.
歯垢染色用組成物に関して、種々の改良が提案されている。例えば、特定の色素成分を含ませることが提案されている（例えば、特許文献１〜３参照。）。また、歯垢染色用組成物に特定の化合物を添加してｐＨ値を調整することが提案され（特許文献４参照。）、また、歯垢染色用成分を含む溶液をカプセル内に封入することが提案されている（特許文献５参照。）。その他、歯垢染色用組成物中に、界面活性剤を特定の態様で含ませることが提案されている（特許文献６参照）。
歯垢染色用組成物は、歯科検診、歯科診療などにおいて大人のみならず子供にも適用され、その染色性能だけでなく、子供にも使いやすい味覚的に不快感のないものが求められている。
しかしながら、従来技術では、歯垢への選択的染色性が高く、且つ使用感の好ましい歯垢染色用組成物が充分に提供されていなかった。
Various improvements have been proposed for plaque staining compositions. For example, it has been proposed to include a specific pigment component (see, for example, Patent Documents 1 to 3). It is also proposed to adjust the pH value by adding a specific compound to the plaque staining composition (see Patent Document 4), and encapsulating a solution containing plaque staining components in a capsule. Has been proposed (see Patent Document 5). In addition, it has been proposed to include a surfactant in a specific form in the plaque staining composition (see Patent Document 6).
Plaque staining compositions are applied not only to adults but also to children in dental examinations and dental practice, and there is a demand not only for their dyeing performance but also for children to have a taste-free discomfort. .
However, the prior art has not sufficiently provided a composition for staining plaque, which has a high selective staining property on plaque and has a favorable feeling of use.
従って本発明は、歯垢染色用色素の歯垢に対する選択的染色性を向上させて、歯肉、口腔粘膜、唇などの不要箇所の染色を抑え、歯垢を視覚的に検出し、且つ味覚的にも優れた歯垢染色用組成物を提供することを目的とする。 Therefore, the present invention improves the selective stainability of plaque staining pigments against plaque, suppresses staining of unnecessary parts such as gingiva, oral mucosa, and lips, visually detects plaque, and taste-sensitive Another object of the present invention is to provide an excellent plaque staining composition.
本発明者は上記課題を達成するために研究を重ねた結果、歯垢染色用組成物にキシリトールを配合し、さらに香料及び界面活性剤を含ませることによって、好ましい歯垢染色用組成物が得られることを見出し、本発明を完成させるに至った。
従って本発明は、キシリトール、香料、界面活性剤及び歯垢染色用色素を含有することを特徴とする歯垢染色用組成物である。
As a result of repeated researches to achieve the above-mentioned problems, the present inventors have obtained a preferable plaque staining composition by blending xylitol into a plaque staining composition and further containing a fragrance and a surfactant. As a result, the present invention has been completed.
Accordingly, the present invention is a plaque staining composition comprising xylitol, a fragrance, a surfactant, and a pigment for staining plaque.
本発明の歯垢染色用組成物によれば、歯垢に対する選択的染色性が高く、歯肉、口腔粘膜、唇などの不要箇所の染色が極めて少なく、歯垢を視覚的に検出することができる。また、本発明の歯垢染色用組成物は香り及び味覚の点からも好ましく使用感が優れていて、大人のみならず子供にも使用し易いものである。 According to the plaque staining composition of the present invention, selective staining for plaque is high, and there is very little staining of unnecessary parts such as gingiva, oral mucosa and lips, and plaque can be detected visually. . In addition, the plaque staining composition of the present invention is preferable in view of fragrance and taste and is excellent in usability, and is easy to use not only for adults but also for children.
以下に本発明を詳しく説明する。
本発明の歯垢染色用組成物にはキシリトールを配合する。本発明で使用するキシリトールは食用、化粧品あるいは医薬品の分野で使用するキシリトールであってよい。キシリトールは歯垢染色用組成物において、適度な湿潤性及び歯垢に対する選択的染色性に寄与すると考えられ、また、適当な甘味を付与できるものである。
歯垢染色用組成物においてキシリトールの配合量は、組成物全量に基づいて０．０５〜５０質量％が適当であって、好ましくは０．１〜２５質量％、より好ましくは０．５〜１５質量％、及び最も好ましくは１〜１０質量％である。
である。
The present invention is described in detail below.
Xylitol is blended in the plaque staining composition of the present invention. The xylitol used in the present invention may be xylitol used in the edible, cosmetic or pharmaceutical fields. Xylitol is considered to contribute to moderate wettability and selective staining for dental plaque in a plaque staining composition, and can impart an appropriate sweetness.
The compounding amount of xylitol in the plaque staining composition is suitably 0.05 to 50% by mass, preferably 0.1 to 25% by mass, more preferably 0.5 to 15%, based on the total amount of the composition. % By weight, and most preferably 1-10% by weight.
It is.
本発明の歯垢染色用組成物にはさらに香料を配合する。
本発明で使用する香料は、通常知られたものの中から対象者によって適宜選んで配合することができ、天然物エキスを主成分とするものが好ましい。特に子供向けの場合は使い易くするために香料の選択は重要であり、中でもフルーツ味が好ましく、イチゴ風味、バナナ風味、ブドウ風味、オレンジ風味、リンゴ味などが好ましく挙げられる。また大人向けには、上記のほかにミント味、スパイシー味などを好みに合わせて各種の風味を付与することができる。
歯垢染色用組成物において香料の配合量は、組成物全量に基づいて０．０１〜１０質量％が適当であって、好ましくは０．０５〜５質量％、より好ましくは０．１〜３質量％である。
A fragrance | flavor is further mix | blended with the composition for plaque staining of this invention.
The perfume used in the present invention can be appropriately selected and blended by the subject from among commonly known ones, and those containing a natural product extract as the main component are preferred. In particular, for children, selection of a fragrance is important for ease of use. Among them, fruit flavor is preferable, and strawberry flavor, banana flavor, grape flavor, orange flavor, apple flavor and the like are preferable. For adults, in addition to the above, various flavors can be imparted according to taste, such as mint flavor and spicy flavor.
In the composition for staining plaque, the blending amount of the fragrance is suitably 0.01 to 10% by mass, preferably 0.05 to 5% by mass, more preferably 0.1 to 3%, based on the total amount of the composition. % By mass.
本発明の歯垢染色用組成物には界面活性剤を配合する。界面活性剤は香料を可溶化する作用を発揮するとともに、歯垢染色用組成物の歯垢に対する選択的染色性に寄与すると考えられる。
本発明で使用する界面活性剤としては口腔内での使用が許容されるものであればよく、例えばグリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンソルビット脂肪酸エステル、ポリエチレングリコール脂肪酸エステル、ポリオキシエチレンヒマシ油、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンアルキルエーテル、ポリオキシエチレンフィトステロール、ポリオキシエチレンフィトスタノール、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、ポリオキシエチレンアルキルフェニルエーテル、ポリオキシエチレンラノリン、ポリオキシエチレンラノリンアルコール、ポリオキシエチレンアルキルアミン、ポリオキシエチレンアルキルエーテルリン酸、モノステアリン酸エチレングリコール・ポリオキシエチレングリコール、ポリオキシエチレンイソステアリルエーテルなどのノニオン界面活性剤を挙げることができる。これらの中でも、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンソルビタン脂肪酸エステル、及びグリセリン脂肪酸エステルが好適に用いられる。さらに好適にはポリオキシエチレン硬化ヒマシ油が用いられる。
歯垢染色用組成物において界面活性剤の配合量は、組成物全量に基づいて０．０５〜１０質量％が適当であって、好ましくは０．１〜１０質量％、より好ましくは０．５〜５質量％である。
A surfactant is blended in the plaque staining composition of the present invention. The surfactant is considered to contribute to the selective staining of the plaque staining composition against plaque as well as exhibiting an action of solubilizing the fragrance.
The surfactant used in the present invention may be any surfactant that can be used in the oral cavity, such as glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit. Fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyoxyethylene phytosterol, polyoxyethylene phytostanol, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene Alkylphenyl ether, polyoxyethylene lanolin, polyoxyethylene lanolin alcohol, polyoxyethylene alkylamine, polyol Shi polyoxyethylene alkyl ether phosphoric acid, ethylene glycol-polyoxyethylene glycol monostearate, may be mentioned nonionic surfactants such as polyoxyethylene isostearyl ether. Among these, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, and glycerin fatty acid ester are preferably used. More preferably, polyoxyethylene hydrogenated castor oil is used.
In the plaque staining composition, the surfactant content is suitably 0.05 to 10% by mass, preferably 0.1 to 10% by mass, more preferably 0.5, based on the total amount of the composition. ˜5 mass%.
本発明で使用する歯垢染色用色素としては、食用、化粧品及び医薬品用のタール系キサンテン色素が好適に挙げられる。該タール系キサンテン色素としては、例えば赤色３号、赤色１０４号、赤色１０５号、赤色１０６号、赤色２３０（１）号、赤色２３０（２）号、赤色２３１号、赤色２３２号、黄色２０２（１）号、黄色２０２（２）号、だいだい２０７号などを挙げることができ、これらの中でも赤色３号、赤色１０４号、赤色１０５号が好適である。
歯垢染色用組成物における歯垢染色用色素の配合量は、歯垢が充分に識別でき且つ経済性を考慮すると、組成物全量に基づいて０．０１〜５質量％が適当であって、好ましくは０．０５〜３質量％、より好ましくは０．１〜２質量％である。
Preferable examples of the pigment for staining plaque used in the present invention include tar-based xanthene pigments for foods, cosmetics and pharmaceuticals. Examples of the tar-based xanthene dye include Red No. 3, Red No. 104, Red No. 105, Red No. 106, Red No. 230 (1), Red No. 230 (2), Red No. 231, Red No. 232, Yellow 202 ( No. 1), yellow 202 (2), No. 207 and the like. Among these, red No. 3, red No. 104, and red No. 105 are preferable.
The compounding amount of the pigment for staining plaque in the plaque staining composition is appropriately 0.01 to 5% by mass based on the total amount of the composition, considering plaque sufficiently and considering the economy, Preferably it is 0.05-3 mass%, More preferably, it is 0.1-2 mass%.
本発明の歯垢染色用組成物には、本発明の効果を損なわない範囲でその他の添加剤を適宜選択して適当な量で配合してもよい。そのような添加剤の例として、湿潤剤、防腐剤、甘味料などが挙げられる。
湿潤剤として例えばグリセリン、プロピレングリコール、ジプロピレングリコール、１，３−ブチレングリコール、ポリエチレングリコールなどがある。中でもグリセリンが好ましく使用される。湿潤剤の配合量としては０．５〜５０質量％が適当であり、好ましくは１．０〜３０質量％であり、より好ましくは３．０〜２０質量％である。
防腐剤として通常使用されるものの中から適宜選択して配合することができるが、色素と組合せて経時的安定性が良いものが望まれる。例えばパラベン、サリチル酸、安息香酸塩、フェノキシエタノールなどから選ぶことができる。
甘味料として通常使用されるものの中から適宜選択して配合することができるが、歯垢への染着性を損なわないものが好ましい。具体的には、サッカリンナトリウムやアスパルテームなどの合成甘味料類、ステビアエキスなどの天然エキス類などを挙げることができる。
本発明の歯垢染色用組成物にはまた、ソルビット、マンニット、マルチトール、エリスリトールなどの糖アルコール類を添加することができ、これらは湿潤剤及び甘味料として効果を発揮できる。
In the plaque staining composition of the present invention, other additives may be appropriately selected and blended in an appropriate amount as long as the effects of the present invention are not impaired. Examples of such additives include wetting agents, preservatives, sweeteners and the like.
Examples of the wetting agent include glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, and polyethylene glycol. Of these, glycerin is preferably used. The blending amount of the wetting agent is suitably 0.5 to 50% by mass, preferably 1.0 to 30% by mass, and more preferably 3.0 to 20% by mass.
Although it can select and mix | blend suitably from what is normally used as an antiseptic | preservative, what combined with a pigment | dye and has good temporal stability is desired. For example, it can be selected from paraben, salicylic acid, benzoate, phenoxyethanol and the like.
Although it can select and mix | blend suitably from what is normally used as a sweetener, the thing which does not impair the dyeing property to plaque is preferable. Specific examples include synthetic sweeteners such as sodium saccharin and aspartame, and natural extracts such as stevia extract.
Sugar alcohols such as sorbitol, mannitol, maltitol, and erythritol can also be added to the plaque staining composition of the present invention, and these can exert an effect as a wetting agent and a sweetener.
本発明の歯垢染色用組成物は種々の剤形に調製することができる。本発明の歯垢染色用組成物は例えば液体状、ゲル状、ペースト状、グミ状、ゼリー状などの剤形とすることができ、使用形態としては塗布剤として、あるいは口中に直接含むことによって使用することができる。
本発明の歯垢染色用組成物はまた、かみ砕き錠などの錠剤、カプセル封入型、練歯磨剤などの歯磨剤、及び洗口剤の使用形態にすることができる。
液体状、ゲル状又はペースト状の形態の歯垢染色用組成物は、例えば、小綿球に付けて患者の歯牙に塗布することができ、また、歯牙に直接滴下することもできる。また、グミ状、ゼリー状、錠剤、カプセル封入型など形態であれば口中に含んで噛んだり潰したりすることで適用することができる。
本発明の歯垢染色用組成物は上記のように種々の剤形を採ることができ、中でも液体状及びペースト状の剤形が一般的である。一方、グミ状やゼリー状の剤形、錠剤、カプセル封入型にすることによって、液だれを防止したり個包装などができるという利点がある。
The plaque staining composition of the present invention can be prepared in various dosage forms. The plaque staining composition of the present invention can be made into a dosage form such as liquid, gel, paste, gummy, jelly, etc., and as a use form, it can be used as a coating agent or directly in the mouth. Can be used.
The plaque staining composition of the present invention can also be used in the form of tablets such as chewable tablets, encapsulated types, dentifrices such as toothpastes, and mouthwashes.
The plaque staining composition in the form of a liquid, gel or paste can be applied to a patient's tooth, for example, attached to a cotton swab, or can be directly dropped onto the tooth. Moreover, if it is a form, such as a gummy form, a jelly form, a tablet, and an encapsulation type, it can be applied by being chewed or crushed in the mouth.
The plaque staining composition of the present invention can take various dosage forms as described above, and liquid and pasty dosage forms are common. On the other hand, there is an advantage that dripping can be prevented or individual packaging can be achieved by using a gummy or jelly dosage form, tablet, or encapsulating type.
本発明の歯垢染色用組成物はその剤形に応じて、水や種々の添加剤を適宜選択して適当な量で配合することができる。例えば、かみ砕き用の錠剤とするときには賦形剤、結合剤、崩壊剤などを適量添加して製剤することができる。
歯磨剤の形態とするときは、上記の成分の他に例えば粘結剤、研磨剤、薬用成分などを配合することができる。粘結剤としてカルボキシメチルセルロースナトリウム、メチルセルロース、ヒドロキシエチルセルロース、キサンタンガム、アルギン酸塩、カラギーナン、アラビアゴム、ポリビニルアルコール、トラガントガム、デンプン、ポリアクリル酸ナトリウムなどが挙げられる。研磨剤としてリン酸水素カルシウム、水酸化アルミニウム、ピロリン酸カルシウム、炭酸カルシウム、含水ケイ酸、無水ケイ酸などが挙げられる。また、薬用成分としてゼオライト、クロルヘキシジン塩類、塩化セチルピリジニウム、塩化ベンザルコニウム、塩化ベンゼトニウム、ビサボロール、トリクロサン、イソプロピルメチルフェノール、酢酸トコフェロール、トラネキサム酸、ジヒドロコレステロール、グリチルレチン酸、グリチルリチン酸塩類、銅クロロフィリン塩、塩化ナトリウム、グァイアズレンスルホン酸塩、塩酸ピリドキシンなどを１種又は２種以上配合することができる。
The plaque staining composition of the present invention can be formulated in an appropriate amount by appropriately selecting water and various additives according to the dosage form. For example, when a tablet for chewing is used, it can be formulated by adding appropriate amounts of excipients, binders, disintegrants and the like.
In the case of a dentifrice, for example, a binder, an abrasive, a medicinal component and the like can be blended in addition to the above components. Examples of the binder include sodium carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, xanthan gum, alginate, carrageenan, gum arabic, polyvinyl alcohol, tragacanth gum, starch, sodium polyacrylate, and the like. Examples of the abrasive include calcium hydrogen phosphate, aluminum hydroxide, calcium pyrophosphate, calcium carbonate, hydrous silicic acid, and anhydrous silicic acid. Further, as medicinal ingredients, zeolite, chlorhexidine salts, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, bisabolol, triclosan, isopropylmethylphenol, acetic acid tocopherol, tranexamic acid, dihydrocholesterol, glycyrrhetinic acid, glycyrrhizinate, copper chlorophyllin salt, Sodium chloride, guaiazulene sulfonate, pyridoxine hydrochloride and the like can be used alone or in combination.
グミ状やゼリー状の剤形とするときには、粘結剤あるいはゲル化剤として例えば寒天、カラギーナン、ファーセレン、アルギン酸、アルギン酸塩類、グアーガム、ローカストビーンガム、タラガム、カシアガム、タマリンドガム、アラビアガム、アラビノガラクタン、トラガントガム、ペクチン、脱アシル型ジェランガム、ネイティブ型ジェランガム、カードラン、プルラン、キサンタンガム、デキストラン、アゾトバクタービネランジーガム、グルコマンナン、デンプン、ゼラチン、カルボキシメチルセルロースナトリウム、メチルセルロース、カラヤガム、キチン、キトサンのうち一種もしくはそれ以上を使用することができる。
ペースト状の剤形とするときに、上記のグミ状やゼリー状の剤形を製造するときと同様の粘結剤を使用することができ、その使用量は剤形がペースト状となるように適宜変動させればよい。
When it is made into a gummy or jelly dosage form, as a binder or gelling agent, for example, agar, carrageenan, farselen, alginic acid, alginates, guar gum, locust bean gum, tara gum, cassia gum, tamarind gum, gum arabic, arabi Nogalactan, tragacanth gum, pectin, deacylated gellan gum, native gellan gum, curdlan, pullulan, xanthan gum, dextran, azotobacter vinegar gum, glucomannan, starch, gelatin, sodium carboxymethylcellulose, methylcellulose, karaya gum, chitin, One or more of chitosan can be used.
When making a paste-like dosage form, the same binder as the above-mentioned gummy and jelly-like dosage forms can be used, and the amount used is so that the dosage form becomes paste-like What is necessary is just to change suitably.
本発明の歯垢染色用組成物は、その剤形に応じて一般的に常法に従って製造することができる。
グミ状やゼリー状の歯垢染色用組成物の製法としては、例えば上記のような粘結剤あるいはゲル化剤を水により膨潤させ、加熱溶解させたところへ、他の成分を加えて作ることができる。
本発明の歯垢染色用組成物をカプセル封入型とするには、本発明に従った例えば液体状、ゲル状又はペースト状の歯垢染色用組成物をカプセルに封入することができる。カプセル材料としては人体に害のない水溶性高分子材料を用いることが適当であり、例えばゼラチン、寒天、プルラン、アルギン酸塩、メチルセルロース、ヒドロキシプロピルセルロースなどを使用することができる。カプセルは、ソフトカプセルでもハードカプセルでもよく、カプセルの形状は特に限定されないが、フットボール型、長楕円型、球形、三角などにすることができる。カプセル皮膜の厚さは一般的に０．６mm以下が適当である。カプセルの製法、及び液体状、ゲル状又はペースト状の歯垢染色用組成物の充填方法などは、公知の方法を採用することができる。ハードカプセルであれば、例えばカプセルボディーとカプセルキャップを予め成形しておき、そこへ歯垢染色用組成物を充填して封鎖する方法が採用できる。また、ソフトカプセルであれば、例えばソフトカプセルを任意の形状に成形してから歯垢染色用組成物を充填して封鎖する方法などが採用できる。
The plaque staining composition of the present invention can be generally produced according to a conventional method depending on its dosage form.
As a method for producing a gummy-like or jelly-like plaque staining composition, for example, the above-mentioned binder or gelling agent is swollen with water, and heated and dissolved to add other ingredients. Can do.
To make the plaque staining composition of the present invention into an encapsulation type, for example, a liquid, gel, or paste plaque staining composition according to the present invention can be encapsulated. As the capsule material, it is appropriate to use a water-soluble polymer material that is not harmful to the human body. For example, gelatin, agar, pullulan, alginate, methylcellulose, hydroxypropylcellulose, and the like can be used. The capsule may be a soft capsule or a hard capsule, and the shape of the capsule is not particularly limited, but can be a football type, an elliptical type, a spherical shape, a triangular shape, or the like. The thickness of the capsule film is generally 0.6 mm or less. Known methods can be employed for the capsule production method and the filling method of the liquid, gel or paste plaque staining composition. In the case of a hard capsule, for example, a capsule body and a capsule cap may be formed in advance, and then filled with a plaque staining composition and sealed. In the case of a soft capsule, for example, a method of forming a soft capsule into an arbitrary shape and then filling and sealing with a plaque staining composition can be employed.
以下に試験例、実施例及び比較例を示し、本発明をより具体的に説明する。
［試験］
以下の表１に示す各種の液体状歯垢染色用組成物（実施例１〜３及び比較例１及び２）を調製した。表１中、単位は質量％であり、水を適量加えて合計１００質量％とした。
該歯垢染色用組成物の歯垢への選択的染色性を、以下に述べるモデル実験にて評価した。
まず、歯垢を想定したモデルとしてデキストラン架橋体粉末を用いた。デキストラン架橋体粉末（商品名：Sephadex G-10）０．１ｇを、適当な容器に採取した上記の各歯垢染色用組成物２０ｇに添加し、約１分間６０rpmで攪拌した。攪拌後、この試料溶液に純水２００mlを加えて染色を停止させ、この溶液を直ちに濾過し、デキストランの染色の度合いを視覚にて、下記に示す基準により評価した。
次に、歯肉を想定したモデルとしてコラーゲン膜を用いた。１cm×１cmのコラーゲン膜（商品名：Nippi Cassing #200）を、適当な容器に採取した上記の各歯垢染色用組成物２０ｇに約１分間浸した後、該コラーゲン膜を２００mlの純水が入ったビーカー中で５〜１０秒間、良くすすぎ、風乾後、コラーゲン膜の染色の度合いを上記と同様に評価した。
Hereinafter, the present invention will be described more specifically by showing test examples, examples and comparative examples.
[test]
Various liquid plaque staining compositions (Examples 1 to 3 and Comparative Examples 1 and 2) shown in Table 1 below were prepared. In Table 1, the unit is mass%, and an appropriate amount of water was added to make a total of 100 mass%.
The selective stainability on plaque of the plaque staining composition was evaluated by a model experiment described below.
First, dextran crosslinked body powder was used as a model assuming dental plaque. 0.1 g of dextran crosslinked product powder (trade name: Sephadex G-10) was added to 20 g of each of the above plaque staining compositions collected in a suitable container, and stirred for about 1 minute at 60 rpm. After stirring, 200 ml of pure water was added to the sample solution to stop the staining, the solution was immediately filtered, and the degree of dextran staining was visually evaluated according to the following criteria.
Next, a collagen membrane was used as a model assuming gingiva. After immersing a 1 cm × 1 cm collagen membrane (trade name: Nippon Cassing # 200) in 20 g of the above-mentioned plaque staining composition collected in a suitable container for about 1 minute, 200 ml of pure water was added to the collagen membrane. After rinsing well in the beaker for 5 to 10 seconds and air-drying, the degree of staining of the collagen membrane was evaluated in the same manner as described above.
＜評価基準＞
５：極めて鮮明に染色される、４：鮮明に染色される、３：やや不鮮明である、２：極めて不鮮明である、１：染色されない
この試験では、歯垢を想定したモデルに対してより高い数値の評価がされ、且つ歯肉を想定したモデルに対してより低い数値の評価がされることが、歯垢染色用組成物として歯垢への選択的染色性が高く性能が良いことになる。そこで、歯垢を想定したモデルに対しての評価と、歯肉を想定したモデルに対しての評価とを鑑みて、下記の基準でさらに総合評価を行った。
＜総合評価基準＞
◎：たいへん良好、○：良好、△：劣る、×かなり劣る
これらの試験結果を表１に併せて示す。
<Evaluation criteria>
5: Stained very clearly, 4: Stained very clearly, 3: Slightly smeared, 2: Slightly smeared, 1: Unstained In this test, higher than the model assuming plaque When the numerical value is evaluated and a lower numerical value is evaluated with respect to the model assuming gingiva, the plaque staining composition has high selective staining ability to plaque and high performance. Therefore, in view of the evaluation with respect to the model assuming dental plaque and the evaluation with respect to the model assuming gingiva, a comprehensive evaluation was further performed according to the following criteria.
<Comprehensive evaluation criteria>
A: Very good, B: Good, B: Inferior, X Inferior These test results are also shown in Table 1.
［実施例４］
以下の組成（単位：質量％）にて、液体状の歯垢染色用組成物を調製した。水を適量加えて合計１００質量％とした。
キシリトール ５．０
香料（メロン味） ０．５
ポリオキシエチレン硬化ヒマシ油 ２．０
赤色３号 ０．５
パラベン ０．１
グリセリン ５．０
水 適量
[Example 4]
A liquid plaque staining composition was prepared with the following composition (unit: mass%). An appropriate amount of water was added to make a total of 100% by mass.
Xylitol 5.0
Fragrance (melon flavor) 0.5
Polyoxyethylene hydrogenated castor oil 2.0
Red No. 3 0.5
Paraben 0.1
Glycerin 5.0
Appropriate amount of water
［実施例５］
以下の組成（単位：質量％）にて、液体状の歯垢染色用組成物を調製した。水を適量加えて合計１００質量％とした。
キシリトール ２．０
香料（リンゴ味） １．０
ポリオキシエチレン硬化ヒマシ油 ３．０
赤色１０５号 １．０
塩化セチルピリジニウム ０．０５
グリセリン ３．０
水 適量
[Example 5]
A liquid plaque staining composition was prepared with the following composition (unit: mass%). An appropriate amount of water was added to make a total of 100% by mass.
Xylitol 2.0
Fragrance (apple flavor) 1.0
Polyoxyethylene hydrogenated castor oil 3.0
Red No. 105 1.0
Cetylpyridinium chloride 0.05
Glycerin 3.0
Appropriate amount of water
［実施例６］
以下の組成（単位：質量％）にて、液体状の歯垢染色用組成物を調製した。水を適量加えて合計１００質量％とした。
キシリトール ３．０
香料（オレンジ味） １．０
ポリオキシエチレン硬化ヒマシ油 ４．０
赤色１０４号 ２．０
安息香酸ナトリウム １．０
グリセリン ２．０
水 適量
[Example 6]
A liquid plaque staining composition was prepared with the following composition (unit: mass%). An appropriate amount of water was added to make a total of 100% by mass.
Xylitol 3.0
Fragrance (orange flavor) 1.0
Polyoxyethylene hydrogenated castor oil 4.0
Red No. 104 2.0
Sodium benzoate 1.0
Glycerin 2.0
Appropriate amount of water
［実施例７］
以下の組成（単位：質量％）にて、グミ状の歯垢染色用組成物を調製した。水を適量加えて合計１００質量％とした。
ゼラチン ７．０
キシリトール ５．０
赤色３号 ０．５
パラベン ０．１
グリセリン ５．０
ポリオキシエチレン硬化ヒマシ油 ３．０
塩化セチルピリジニウム ０．０１
香料（イチゴ味） １．０
水 適量
調製法：ゼラチンを予め水で膨潤させ、５０〜６０℃にて加熱溶解する。溶解した後に他の成分を加え、水を適量加えて合計１００質量％とする。
[Example 7]
A gummy plaque staining composition was prepared with the following composition (unit: mass%). An appropriate amount of water was added to make a total of 100% by mass.
Gelatin 7.0
Xylitol 5.0
Red No. 3 0.5
Paraben 0.1
Glycerin 5.0
Polyoxyethylene hydrogenated castor oil 3.0
Cetylpyridinium chloride 0.01
Fragrance (strawberry flavor) 1.0
Method for preparing an appropriate amount of water: Gelatin is swollen with water in advance and dissolved by heating at 50 to 60 ° C. After dissolution, other components are added, and an appropriate amount of water is added to make a total of 100% by mass.
［実施例８］
以下の組成（単位：質量％）にて、ゼリー状の歯垢染色用組成物を調製した。水を適量加えて合計１００質量％とした。
寒天 ３．０
キサンタンガム ０．５
キシリトール ３．０
赤色３号 ０．５
パラベン ０．１
グリセリン ３．０
ポリオキシエチレン硬化ヒマシ油 ２．０
塩化セチルピリジニウム ０．０１
香料（リンゴ味） ０．５
水 適量
調製法：寒天を予め水に浸漬させ、８０℃以上に加熱して溶解する。溶解した後に他の成分を加え、水を適量加えて合計１００質量％とする。
[Example 8]
A jelly-like plaque staining composition was prepared with the following composition (unit: mass%). An appropriate amount of water was added to make a total of 100% by mass.
Agar 3.0
Xanthan gum 0.5
Xylitol 3.0
Red No. 3 0.5
Paraben 0.1
Glycerin 3.0
Polyoxyethylene hydrogenated castor oil 2.0
Cetylpyridinium chloride 0.01
Fragrance (apple flavor) 0.5
Water suitable amount preparation method: Agar is previously immersed in water and dissolved by heating to 80 ° C. or higher. After dissolution, other components are added, and an appropriate amount of water is added to make a total of 100% by mass.
［実施例９］
以下の組成にて、カプセル封入型歯垢染色用組成物を調製した。
歯垢染色液（単位：質量％）
キシリトール ５．０
香料（イチゴ味） １．０
ポリオキシエチレン硬化ヒマシ油 ５．０
赤色３号 ０．５
安息香酸ナトリウム ０．５
グリセリン ２５．０
水 適量
計 １００．０
被膜材（単位：質量％）
ゼラチン ７５．０
グリセリン １２．３
ソルビット液（７０％） ４．０
スクラロース ０．５
アセスルファムカリウム ０．２
水 ８．０
計 １００．０
調製法：被膜材の成分であるゼラチン、グリセリン及びソルビット液の混合液に水を加えて、６５〜７５℃の温度条件下にて溶解混合する。こうして得られた被膜原体にスクラロース及びアセスルファムカリウムを加えて攪拌し、被膜材とした。歯垢染色液及び被膜材をカプセル成形機に適用してカプセル封入型歯垢染色用組成物を得る。
[Example 9]
An encapsulated plaque staining composition was prepared with the following composition.
Plaque stain solution (unit: mass%)
Xylitol 5.0
Fragrance (strawberry flavor) 1.0
Polyoxyethylene hydrogenated castor oil 5.0
Red No. 3 0.5
Sodium benzoate 0.5
Glycerin 25.0
Water appropriate amount Total 100.0
Film material (unit: mass%)
Gelatin 75.0
Glycerin 12.3
Sorbit liquid (70%) 4.0
Sucralose 0.5
Acesulfame potassium 0.2
Water 8.0
Total 100.0
Preparation method: Water is added to a mixed solution of gelatin, glycerin and sorbite liquid, which are components of the coating material, and dissolved and mixed under a temperature condition of 65 to 75 ° C. Sucralose and acesulfame potassium were added to the original coating material thus obtained and stirred to obtain a coating material. A plaque staining liquid and a coating material are applied to a capsule molding machine to obtain an encapsulated plaque staining composition.
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005047348A JP4841146B2 (en) | 2004-04-16 | 2005-02-23 | Plaque staining composition |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004121608 | 2004-04-16 | ||
| JP2004121608 | 2004-04-16 | ||
| JP2005047348A JP4841146B2 (en) | 2004-04-16 | 2005-02-23 | Plaque staining composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005325095A JP2005325095A (en) | 2005-11-24 |
| JP4841146B2 true JP4841146B2 (en) | 2011-12-21 |
Family
ID=35471729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005047348A Active JP4841146B2 (en) | 2004-04-16 | 2005-02-23 | Plaque staining composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4841146B2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106890117B (en) * | 2017-03-21 | 2020-07-28 | 广州薇美姿实业有限公司 | Plaque color developing toothpaste containing food blue and preparation method thereof |
| CN106890118B (en) * | 2017-03-21 | 2020-07-28 | 广州薇美姿实业有限公司 | Dental plaque color developing toothpaste containing acid red and preparation method thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5820929B2 (en) * | 1972-10-30 | 1983-04-26 | ライオン株式会社 | Koukouso Saibutsu |
| JP2000136119A (en) * | 1998-08-25 | 2000-05-16 | Gc Corp | Composition for preventing dental caries |
| JP2001114659A (en) * | 1999-10-13 | 2001-04-24 | Lion Corp | Composition for oral cavity |
| JP2002138056A (en) * | 2000-10-31 | 2002-05-14 | Wildent:Kk | Testing agent for dental plaque dyeing |
| JP2002193776A (en) * | 2000-12-25 | 2002-07-10 | Lion Corp | Cleaning agent for oral cavity |
| JP2002241251A (en) * | 2001-02-14 | 2002-08-28 | Tanpei Seiyaku Kk | Plaque dyeable toothpaste |
| JP5084075B2 (en) * | 2001-02-28 | 2012-11-28 | サンスター株式会社 | Oral cleaning composition |
| JP2002265340A (en) * | 2001-03-07 | 2002-09-18 | Tanpei Seiyaku Kk | Bacterial plaque-staining liquid dentifrice |
| JP4517101B2 (en) * | 2001-08-21 | 2010-08-04 | 学校法人日本大学 | Plaque staining composition |
| JP2004151002A (en) * | 2002-10-31 | 2004-05-27 | Kansai Koso Kk | Dental plaque staining composition |
-
2005
- 2005-02-23 JP JP2005047348A patent/JP4841146B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005325095A (en) | 2005-11-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7251998B2 (en) | Liquid oral composition | |
| JP5548969B2 (en) | Dentifrice composition | |
| KR20090086433A (en) | Oral composition containing crystalline cellulose surface-treated with water-soluble substance | |
| TW201446276A (en) | Oral care composition and processes for preparing same | |
| JP5196127B2 (en) | Oral composition | |
| KR101733916B1 (en) | Toothpaste comprising natural surface-active agent and the fabrication method the same | |
| JP5084075B2 (en) | Oral cleaning composition | |
| JP7447470B2 (en) | dentifrice composition | |
| CN117530875A (en) | Amino acid toothpaste and preparation method thereof | |
| JP4143829B2 (en) | Oral composition | |
| JP5924049B2 (en) | Toothpaste composition | |
| JP4841146B2 (en) | Plaque staining composition | |
| JP2006347986A (en) | Composition for oral cavity | |
| JP2004300120A (en) | Oral cavity composition | |
| JP2012188377A (en) | Oral composition | |
| AU2010332953B2 (en) | Compositions comprising alginates with high guluronic acid/mannuronic acid ratio for use in the treatment of dentine hypersensitivity | |
| KR102322170B1 (en) | Toothpaste composition | |
| KR100704585B1 (en) | Toothpaste composition | |
| JPH10236934A (en) | Oral composition | |
| JP7459489B2 (en) | Oral composition | |
| EP2790653B1 (en) | Oral care composition | |
| RP et al. | FORMULATION AND EVALUATION OF RICE BRAN OIL INCORPORATED TOOTHPASTE FOR ORAL HYGIENE | |
| JP5720416B2 (en) | Gel oral composition and method for producing the same | |
| WO2022102628A1 (en) | Composition for oral cavity | |
| JP2006124362A (en) | Intraoral state-improving composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080123 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20100430 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100510 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100708 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110704 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110901 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20110926 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20111004 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 4841146 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20141014 Year of fee payment: 3 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |