JP5924049B2 - Toothpaste composition - Google Patents

Description

  The present invention relates to a dentifrice composition containing sodium chloride, more specifically, it is excellent in the effect of imparting a feeling of tightening gingiva, gives a foam excellent in retention in the oral cavity, and has a good appearance of the preparation, particularly smooth skin. It relates to a dentifrice composition.

In a dentifrice composition for preventing periodontal disease, it is effective to add sodium chloride as a component that exerts a gum tightening effect.
However, the dentifrice composition containing sodium chloride has a problem that foaming is poor and the foam becomes watery and easily drops from the mouth while brushing teeth.

  On the other hand, in order for the medicinal component to effectively act on the application site such as gums, it is considered important that the foam continuously contacts and stays in the application site while brushing the teeth. Thus, in the dentifrice composition containing sodium chloride having a problem in foam performance, it has been difficult to provide a foam having good retention properties that can continuously contact the application site.

  Conventionally, as a technique for improving foam performance degradation due to sodium chloride, a dentifrice composition appropriately mixed with xanthan gum, betaine-type amphoteric surfactant, and sodium lauryl sulfate has been proposed in Patent Document 1 (Japanese Patent Laid-Open No. 2009-137908). ing. However, this is an improvement in foamability and persistence of foaming, and no mention is made of the foam retention in the oral cavity.

  Patent Document 2 (Japanese Patent Laid-Open No. 2006-347987) includes xanthan gum, alginates, anionic surfactants and nonionic surfactants as techniques for improving the foam performance and oral retention properties of oral compositions. The composition for oral cavity which the foaming amount was moderate and the sustainability of foam was improved by mix | blending is proposed. Patent Document 3 (Japanese Patent Laid-Open No. 2007-291021) contains alginic acid or a salt thereof, xanthan gum, and κ-carrageenan, thereby improving the adhesion to the gums, teeth, and oral retention. Is proposed, and further describes that silica can be blended. However, Patent Documents 2 and 3 are not improvements in foam performance in a sodium chloride-containing dentifrice composition.

JP 2009-137908 A JP 2006-347987 A JP 2007-291021 A JP 2008-115114 A

  Therefore, in a dentifrice composition containing sodium chloride, improvement of foam performance, particularly foam retention in the oral cavity, has been a technical problem.

  The present invention has been made in view of the above circumstances, and provides a dentifrice composition containing sodium chloride that is excellent in gingival tightening feeling imparting effect, gives foam excellent in retention in the oral cavity, and has a good formulation appearance. The purpose is to provide.

As a result of intensive studies to achieve the above object, the inventors of the present invention have added (B) xanthan gum and (C) alginic acid to (A) a dentifrice composition containing sodium chloride and a surfactant. By blending sodium, (D) thickening silica, and (E) carrageenan, it has excellent effect of imparting a firm feeling of gingiva, and gives a foam with good retention that can continuously contact the application site in the oral cavity. And it discovered that it was excellent in the external appearance of a formulation, especially kneaded skin, and came to make this invention.

  That is, when the present inventors formulated xanthan gum and sodium alginate in a dentifrice composition containing sodium chloride, the foaming was improved, and the standing foam did not disappear easily, and the foam stayed at the application site such as gums. However, in this case, it was found that the appearance of the preparation, in particular, the kneaded skin was deteriorated, and the surface was rough. Moreover, it turned out that such a fall of the kneaded skin is a new subject which arose by combined use of both components of a xanthan gum and sodium alginate, and does not arise by the combination of xanthan gum or sodium alginate alone. Therefore, as a result of further studies to solve this problem, when the thickened silica, particularly the thickened silica having a specific bulk density, is blended with xanthan gum and sodium alginate, the problem of the kneaded skin is solved, and the tooth It has been found that a dentifrice composition can be obtained that is excellent in tightening feeling and foam retention in the oral cavity and that allows sodium chloride to effectively act on the application site.

It should be noted that the deterioration of the paste skin in the dentifrice composition is often caused by the aggregation of a surfactant such as a nonionic surfactant, the aggregation of the binder, and the blended powder. In general, resolution is considered. In particular, the addition of powder usually causes a decrease in kneaded skin. However, in the present invention, especially by adding a thickened silica powder having a specific bulk density, the kneaded skin is unexpectedly surprised. It improves and gives the above special effects.
Patent Document 4 (Japanese Patent Application Laid-Open No. 2008-115114) includes sodium chloride, sodium alginate, and xanthan gum as a dentifrice composition in which the appearance of a paste preparation (surface roughening) at low temperature storage is suppressed, and is anhydrous as an abrasive. Although a composition containing silicic acid is described, this is a technique for improving the appearance of the preparation by incorporating a specific surfactant. From this technique, it is difficult to predict the technical idea of the present invention that improves the kneaded skin with the thickened silica powder and gives special effects.

Accordingly, the present invention provides (A) a toothpaste composition containing 3 to 10% by weight of sodium chloride and a surfactant , and (B) 0.1 to 1% by weight of xanthan gum , and (C) alginic acid. sodium 0.5-2 wt%, a toothpaste composition, characterized in that by blending from 0.5 to 1 wt% 1-2 wt% and (E) carrageenan (D) thickening silica provide.

  According to the present invention, it is possible to provide a dentifrice composition containing sodium chloride that is excellent in the effect of imparting a tightening sensation of gingiva, gives foam excellent in retention in the oral cavity, and has a good formulation appearance.

  The present invention will be described in further detail below. The dentifrice composition of the present invention is characterized by containing (A) sodium chloride, (B) xanthan gum, (C) sodium alginate, and (D) thickening silica.

  (A) A commercial item can be used for sodium chloride. For example, Sanuki salt and carefully selected special salt made by Nihonkaikai Co., Ltd. can be used.

  The blending amount of the component (A) is preferably 1 to 15% (mass%, the same applies hereinafter) of the whole composition, more preferably 3 to 10%. If the blending amount is less than 1%, sufficient gingival firmness may not be obtained. If it exceeds 15%, the foam retention may not be sufficiently improved. Moreover, saltiness may become too strong and a usability | use_condition may fall.

  In the present invention, it is important to combine (B) xanthan gum and (C) sodium alginate to improve the foam retention of the sodium chloride-containing dentifrice composition, and the component (B) or the component (C) When lacking is inferior in foam retention, the object of the present invention cannot be achieved.

(B) Xanthan gum is a polysaccharide obtained by fermentation using Xanthomonas campestris, and is mainly composed of D-glucose, D-mannose and D-glucuronic acid as a base, sodium salt, potassium salt, Calcium salts are also included.
Any xanthan gum may be used as long as it is usually used in a dentifrice composition, but the viscosity of xanthan gum is 600 to 2,000 mPa · s in a 1% xanthan gum aqueous solution containing 1% potassium chloride. In particular, those of 1,000 to 2,000 mPa · s are preferred. The above-mentioned viscosity is a Brookfield type rotational viscometer, rotor No. 3, 60 rpm, 25 ° C., measurement time 30 seconds.

  As such xanthan gum, commercially available products such as Novazan manufactured by ADM Far East Co., Ltd., Monato Gum DA manufactured by CP Kelco, Kelzan T, Keldent, Echo Gum manufactured by Dainippon Pharmaceutical Co., Ltd. and the like can be used.

  (B) 0.01-2% of the whole composition is preferable, and, as for the compounding quantity of a xanthan gum, More preferably, it is 0.1-1%. If the blending amount is less than 0.01%, the foam retention may not be improved. If it exceeds 2%, the kneaded skin may be deteriorated. In addition, the preparation may be inferior in use feeling.

(C) Any sodium alginate may be used as long as it is usually used in a dentifrice composition, and in particular, a 2% aqueous solution of sodium alginate has a viscosity of 1,000 to 4,000 mPa · s. Of these, 2,000 to 4,000 mPa · s is particularly preferable. In addition, the said viscosity is BL type | mold rotational viscometer, rotor No. 3, 12 rpm, 25 ° C., measurement time 3 minutes.
Examples of sodium alginate include commercially available Kimika Argin manufactured by Kimika Co., Ltd.

  (C) 0.01-2.5% of the whole composition is preferable, and, as for the compounding quantity of sodium alginate, More preferably, it is 0.5-2%. If the blending amount is less than 0.01%, the foam retention may not be improved. If it exceeds 2.5%, the preparation may be inferior in use feeling.

  The (D) component thickening silica is an important component for improving the decrease in kneaded skin due to the combined use of the (A) component and the (B) and (C) components, and giving a good formulation appearance.

As the thickening silica, silica obtained by a known production method such as precipitated silica and ignitable silica having a liquid absorption amount of 2.0 to 3.0 ml / g can be used. Thickened silica has the above-described liquid absorption amount, is fine, has little abrasiveness, and is not usually used as an abrasive. The liquid absorption amount of the abrasive silica is usually less than 2.0 ml / g, which is different from the liquid absorption amount of the thickening silica as the component (D).
The liquid absorption amount is as follows.
A sample (1.0 g) is weighed on a clean glass plate, and the sample is mixed with a stainless steel spatula using a microburet while dripping 42.5% glycerin little by little. The amount of liquid (ml) required until the sample became one lump and peeled cleanly from the glass plate with a spatula was taken as the liquid absorption amount.

As the thickening silica, it is particularly preferable to use a fine powder having a large bulk density in order to achieve the effect of the present invention.
The bulk density of the thickening silica is preferably 100 to 160 g / L, more preferably 120 to 160 g / L. If the bulk density is less than 100 g / L, the kneaded skin may not be improved. If it is larger than 160 g / L, the foam retention may not be improved.
The bulk density was measured by the following method.
Gently weigh about 100 g of sample (M) into a dry 250 mL graduated cylinder without compaction. Carefully level the upper surface of the powder layer without compacting and read the loose bulk volume (V ₀ ) to the smallest scale unit. The bulk density is calculated by M / V ₀ .

  As such thickening silica, commercially available ones can be used, for example, Carplex # 67Q manufactured by DSL Japan Co., Ltd. can be used.

  (D) 0.5-3% of the whole composition is preferable, and, as for the compounding quantity of thickening silica, More preferably, it is 1-2%. If the blending amount is less than 0.5%, the kneaded skin may not be improved. If it exceeds 3%, the foam retention may be inferior.

  In the present invention, it is preferable to further blend (E) carrageenan. When (E) component is mix | blended with (B) and (C) component, the foam which is more dull and has high retention property will be obtained, and the effect of this invention can be heightened.

  Examples of carrageenan include κ (kappa) -carrageenan, ι (iota) -carrageenan, and λ (lambda) -carrageenan, but ι (iota) -carrageenan can be preferably used. You may use together. Examples of the iota-carrageenan include GENUVISCO type PJ-JPE and GENUGEL type CJ manufactured by CP Kerco.

  (E) When mix | blending carrageenan, 0.5 to 1.5% of the whole composition is preferable, More preferably, it is 0.5 to 1%. If the blending amount is less than 0.5%, foam having higher retention may not be obtained. If it exceeds 1.5%, the kneaded skin may not be improved.

  The dentifrice composition of the present invention can be suitably prepared as a toothpaste, liquid toothpaste, moisturized toothpaste and the like, particularly as a toothpaste. Moreover, in addition to the said component, this invention composition can mix | blend well-known additives other than the said component according to a dosage form in the range which does not impair the effect of this invention. For example, abrasives, binders, thickeners, surfactants, and if necessary, sweeteners, preservatives, colorants, fragrances, active ingredients and the like can be blended.

As abrasives, silica-based abrasives such as silica gel, precipitated silica, aluminosilicate, zirconosilicate, dicalcium phosphate dihydrate and anhydrous, tricalcium phosphate, tetracalcium phosphate, calcium pyrophosphate, calcium carbonate, water Examples thereof include aluminum oxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zeolite, zirconium silicate, hydroxyapatite, and synthetic resin abrasive.
The blending amount of these abrasives is usually 2 to 50% of the whole composition, and 10 to 40% is particularly preferable.

  As a binder, you may mix | blend things other than a xanthan gum, sodium alginate, carrageenan, and thickening silica in the range which does not inhibit the effect of this invention. Examples include sodium carboxymethyl cellulose, hydroxyethyl cellulose, guar gum, cationized cellulose, montmorillonite, gelatin, sodium polyacrylate, and the like. When these binders are blended, the blending amount is preferably 2% or less of the entire composition.

  Examples of the thickener include sugar alcohols such as sorbit, xylit, malt, and lactit, and polyhydric alcohols such as glycerin and propylene glycol. These blending amounts are usually preferably 5 to 50%, particularly preferably 20 to 45% of the total composition.

As the surfactant, an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant can be blended.
Specifically, as anionic surfactants, alkyl sulfates such as sodium lauryl sulfate or salts thereof, acyl sarcosine salts such as sodium lauroyl sarcosine, α-olefin sulfonates, etc., cationic surfactants are alkyl ammonium, Examples thereof include alkylbenzyl ammonium salts.
Examples of the nonionic surfactant include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene copolymer, alkyl glucoside, sucrose fatty acid ester, sorbitan fatty acid ester and the like.
Examples of amphoteric surfactants include betaine acetate, imidazolinium betaine and amidopropyl betaine. Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts.
The compounding amount of the surfactant is usually 0.2 to 15%, particularly 0.5 to 10% of the whole composition.

Examples of the sweetener include saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl hydrochalcone, and perilartin.
Examples of the preservative include parabens such as methyl paraben, butyl paraben and ethyl paraben, benzoic acid or a salt thereof, and the like.
Examples of the colorant include blue No. 1, yellow No. 4, titanium dioxide and the like.

Perfumes are peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime Oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute peppermint Natural fragrances such as absolute rose and orange flower, fragrances obtained by processing these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder fragrance, etc.), and menthol, Carvone, Anethole, Cineol, Methyl salicylate, C Namic aldehyde, eugenol, 3-l-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramentane-3-carboxamide, pinene, octylaldehyde, citral , Pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, hexanal, propyl alcohol, butanol, isoamyl alcohol, Hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, ethylthioacetate, etc. Known perfume used in dentifrice compositions such as single-flavored flavors, and other flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, and tropical fruit flavor. Perfume material can be used.
Moreover, although a compounding quantity is not specifically limited, It is preferable to use said fragrance | flavor raw material 0.000001 to 1% in a formulation composition. Moreover, as a fragrance | flavor for fragrance | flavor which uses the said fragrance | flavor raw material, it is preferable to use 0.1 to 2.0% in a formulation composition.

  Active ingredients other than sodium chloride, for example, fluorides such as sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride, sodium monofluorophosphate, potassium salt of orthophosphoric acid, sodium salt, etc. Water-soluble phosphate compounds, glucanases such as dextranase and mutanase, allantoinchlorohydroxyaluminum, hinokitiol, ascorbic acid, lysozyme chloride, glycyrrhizic acid and its salts, tranexamic acid, epsilon aminocaproic acid, dl-tocopherol acetate, α-bisabolol , Isopropylmethylphenol, chlorohexidine salts, cetylpyridinium chloride, azulene, glycyrrhetinic acid, copper compounds such as copper chlorophyllin sodium, copper gluconate, aluminum lactate, strontium chloride , Potassium nitrate, berberine, hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite, amylase, methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterin, benzethonium chloride, dihydrocholesterol, trichlorocarbanilide, citric acid Examples include plant extracts such as zinc, soft sugar beet extract, buckwheat extract, clove, rosemary, hornon, safflower. In addition, the said active ingredient can be mix | blended in an effective amount in the range which does not prevent the effect of this invention.

EXAMPLES Hereinafter, although an Example , a reference example, and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified. Further, the amount of liquid absorption, bulk density, and viscosity in the raw materials used are values measured by the same method as described above.

[Examples, Reference Examples, Comparative Examples]
Dentifrice compositions having the compositions shown in Tables 1 to 3 were prepared by conventional methods and evaluated as follows. The results are shown in Tables 1-3.

<Evaluation method of gingival tightening feeling>
Ten test subjects put about 1 g of the dentifrice composition on a toothbrush having a brush head width of 10 mm and a length of 20 mm, and evaluated the gingival tightening feeling when brushing the teeth for 3 minutes in four stages. 4 points for "feeling the gums tightened well", 3 points for "feeling gums tightened", 2 points for "feeling gums slightly tightened", and "feeling gums tightened" “No” was taken as one point, and the feeling of tightening gums was evaluated based on the following criteria from the average score of 10 people.
Evaluation criteria A: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points Δ: Average point 2.0 points or more and less than 3.0 points ×: Average point 1. 0 points or more and less than 2.0 points

<Method for evaluating foam retention>
A 4-fold diluted solution of the dentifrice composition was brushed using a toothbrush with a brush head width of 10 mm and a length of 20 mm at a load of 200 g, a number of brushes of 1,000 times, a speed of 150 rpm, and a stroke width of 36 mm, and foamed. 1ml of foamed foam is applied to the range from the first premolar to the second premolar of the jaw model (mandible), and the remaining amount of foam after 1 minute compared with immediately after application is visually evaluated according to the following criteria. Thus, the retention of bubbles in the oral cavity was evaluated.
Evaluation criteria ◎: Residual amount 80% or more ○: Residual amount 70% or more and less than 80% △: Residual amount 60% or more and less than 70% ×: Residual amount less than 60%

<Evaluation method of goodness of kneaded skin>
50 g of the dentifrice composition was filled into a laminated tube, extruded 15 cm onto a straw half paper, and the presence or absence of gloss on the surface of the dentifrice and whether wrinkles were observed were evaluated. 4 points for "Diffusion on surface of dentifrice and no wrinkles", 3 for "There is gloss on the surface of dentifrice and no wrinkles", "No gloss on dentifrice surface An average of 5 evaluations was made based on the following criteria based on the following criteria: 2 points for “wrinkle was observed” and 1 point for “no dentifrice surface was glossy and wrinkle was recognized”.
Evaluation criteria A: 3.5 to 4.0 points ○: 3.0 to less than 3.5 points Δ: 2.0 to less than 3.0 points ×: Less than 2.0 points

The details of the raw materials used are as follows.
(A) Sodium chloride; Sanuki salt, selected special salt, Nippon Seawater Co., Ltd. (B) Xanthan gum; Monato gum DA (viscosity 1,500 Pa · s), CP Kelco (C) sodium alginate; Kimika algin (viscosity 3, 000 mPa · s), Kimika Co., Ltd. (D) thickening silica; Carplex # 67Q (precipitating silica, liquid absorption 2.3 ml / g, bulk density 150 g / L), DSL Japan Co., Ltd. (E ) Carrageenan; Carrageenan, GENUVISCO type PJ-JPE, CP Kelco sodium carboxymethylcellulose; CMC1260, manufactured by Daicel Chemical Industries, Ltd.

  From the results of Table 3, when the component (B) or (C) is lacking (Comparative Examples 1 and 2), the foam retention is poor, and when the component (D) is lacking, the skin is inferior, and (B) Even when carboxymethylcellulose was used in combination with the ingredients, the foam retention was not improved. On the other hand, when (B), (C), and (D) component are mix | blended with the dentifrice composition containing (A) component (Example of Tables 1 and 2), it is effective for the tightening feeling imparting effect of gingiva. It has been found that a foam having excellent and good retention properties can be obtained, and a preparation with good kneaded skin can be obtained.

  A prescription example is shown below. The dentifrice composition of the formulation example prepared using the raw material similar to the above was excellent in the effect of imparting a feeling of tightening gingiva and having good foam retention and kneaded skin.

[Prescription Example 1]
Sodium chloride 5.0
Xanthan gum 0.3
Sodium alginate 0.8
Thickening silica 1.2
Carrageenan 0.8
Propylene glycol 4.0
Silica anhydride 10.0
Sodium lauryl sulfate 2.0
Isopropylmethylphenol 0.5
Lauroyl sarcosine sodium 0.1
Fragrance 1.2
Purified water remaining
Total 100.0%

[Prescription Example 2]
Sodium chloride 7.0
Xanthan gum 0.2
Sodium alginate 0.9
Thickening silica 1.0
Carrageenan 0.8
Propylene glycol 4.0
Sorbit 45.0
Silica anhydride 11.0
Sodium lauryl sulfate 2.0
Sodium monofluorophosphate 0.7
Isopropylmethylphenol 1.0
Lauroyl sarcosine sodium 0.2
Fragrance 1.3
Purified water remaining
Total 100.0%

[Prescription Example 3]
Sodium chloride 4.0
Xanthan gum 0.5
Sodium alginate 0.7
Thickening silica 0.8
Carrageenan 0.6
Propylene glycol 4.0
Sorbit 40.0
Silicic anhydride 15.0
Sodium lauryl sulfate 1.4
Sodium citrate 0.2
Isopropylmethylphenol 1.0
Fragrance 1.1
Purified water remaining
Total 100.0%

[Prescription Example 4]
Sodium chloride 9.0
Xanthan gum 0.2
Sodium alginate 0.7
Thickening silica 1.7
Carrageenan 0.9
Propylene glycol 3.0
Sorbit 40.0
Silicic anhydride 12.0
Sodium citrate 0.3
Sodium lauryl sulfate 1.0
Isopropylmethylphenol 0.7
Methyl paraoxybenzoate 0.2
Fragrance 1.0
Purified water remaining
Total 100.0%

Claims (4)

(A) Toothpaste composition containing 3 to 10% by weight of sodium chloride and a surfactant , 0.1 to 1% by weight of (B) xanthan gum , (C) 0.5 to 0.5 % of sodium alginate 2 wt%, toothpaste composition, characterized in that by blending from 0.5 to 1 wt% 1-2 wt% and (E) carrageenan (D) thickening silica. Component (D), according to claim 1 toothpaste composition wherein the thickening silica having a bulk density of 100 to 160 g / L. The toothpaste composition according to claim 1 or 2, wherein the component ( D) is a thickening silica having a liquid absorption amount of 2.0 to 3.0 ml / g. The toothpaste according to claim 1, 2 or 3, wherein, when a binder other than the components (B), (C), (D) and (E) is blended, the blending amount is 2% by mass or less. Composition.