JPH04159212A - Liquid transparent composition for oral cavity - Google Patents

Abstract

PURPOSE:To obtain the title composition preventing turbidity and dregs even in low-temperature storage by adding a p-oxybenzoic ester to a combination of perfume and a nonionic surfactant of polyoxyethylene-polyoxypropylene block polymerization type. CONSTITUTION:A perfume-containing transparent composition for oral cavity blended with a nonionic surfactant of polyoxyethylene-polyoxypropylene block polymerization type is mixed with preferably about 0.05-0.5% based on the whole amount of a composition of a p-oxybenzoic ester (e.g. methylparaben) to give a liquid transparent composition for oral cavity of mouth washing agent or refreshing agent in the mouth. The composition will not cause turbidity and dregs in storage especially at low temperature and does not damage transparent appearance.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to a liquid transparent composition for oral cavity such as a mouthwash and a freshener, which does not cause cloudiness or scum even when stored at low temperatures. The present invention relates to a liquid transparent oral cavity composition.

[Prior art and problems to be solved by the invention] Conventionally, liquid oral compositions such as mouthwashes have contained various water-insoluble ingredients such as fragrances. Various surfactants are used for solubilization. Among these surfactants, solubilizing power, taste, irritation,
Nonionic surfactants are widely used from the viewpoint of foaming and other usability, especially polyoxyethylene hydrogenated castor oil and polyoxyethylene/polyoxypropylene blocks made by block copolymerization of polyoxyethylene and polyoxypropylene. Polymerizable nonionic surfactants and the like are widely used.

However, in liquid transparent oral compositions such as mouthwashes containing fragrances, especially peppermint oil, spearmint oil, citrus oil, etc., polyoxyethylene and
When oral compositions containing a polyoxypropylene block polymerizable nonionic surfactant were stored at low temperatures, cloudiness and oozing occurred. The cause of these problems is thought to be mainly due to insufficient solubilization of the surfactant, but it is not desirable for a liquid transparent oral composition to become cloudy or cloudy during storage, impairing its transparent appearance. Therefore, it was desired to maintain a transparent appearance even when stored at low temperatures.

[Means and effects for solving the problem] The present inventors,
In order to meet the above demands, we have created a liquid transparent oral composition containing a fragrance containing a polyoxyethylene/polyoxypropylene block polymerizable nonionic surfactant that does not cause cloudiness or buildup even when stored at low temperatures. As a result of intensive studies on oral compositions, it was discovered that the above object can be achieved by using paraoxybenzoic acid ester in combination, leading to the present invention.

Paraoxybenzoic acid ester is known as a preservative, and paraoxybenzoic acid ester is combined with a polyoxyethylene/polyoxypropylene block polymerization type nonionic surfactant and incorporated into a fragrance-containing liquid transparent oral composition. It is a new finding by the present inventors that this suppresses the occurrence of cloudiness and ooze in the composition during low-temperature storage.

The present invention will be explained in more detail below.

As described above, the liquid transparent oral composition according to the present invention contains a paraoxybenzoic acid ester in a liquid transparent oral composition containing a fragrance and a polyoxyethylene/polyoxypropylene block polymerized nonionic surfactant. This is what happens.

Here, the polyoxyethylene/polyoxypropylene block polymerization type nonionic surfactant is expressed by the following formula % formula % (However, either a or c is an integer of 1 or more,
The other is an integer of 0 or 1 or more. ) is preferably used. In this case, a+C is 4 to 300, especially 1
50-260 is preferable, b is 10-100, especially 25
~70 is preferred.

Such a polyoxyethylene/polyoxypropylene block polymerization type nonionic surfactant has a polypropylene glycol molecular weight of 50% or more (weight%, hereinafter the same) or more of ethylene oxide in the total molecule, and a polypropylene glycol molecular weight of 175%.
0 or more, for example, polyoxyethylene and polyoxypropylene have an average degree of polymerization of about 200 and about 70, respectively, and polyoxyethylene and polyoxypropylene have an average degree of polymerization of about 260 and about 60, respectively. As a commercially available product, BASF
Pluronic F-127 manufactured by Wyandotte, etc. can be used.

The blending amount of this surfactant is preferably 0.1 to 10%, particularly preferably 1 to 5%, based on the entire liquid transparent oral cavity composition. If the amount of surfactant is less than 0.1%, it may be difficult to solubilize the fragrance;
If it exceeds %, the taste.

It may have an adverse effect on the feeling of use, such as irritation and foaming.

Next, paraoxybenzoic acid esters represented by the following formula (R is a lower alkyl group) are preferably used, such as methylparaben, ethylparaben, and propylparaben.

Examples include butylparaben, and one type thereof may be used alone or two or more types may be used in combination. The content of these paraoxybenzoic acid esters is preferably 0.05 to 0.5% of the total liquid transparent oral cavity composition. If the blending amount is less than 0.05%, the effect of preventing cloudiness and sludge may not be sufficiently exhibited;
．． If it exceeds 5%, it may have an adverse effect on the feeling of use.

A fragrance is blended into the oral composition of the present invention.

Fragrances include Q-menthol, peppermint oil,
Spearmint oil, anethole, lemon oil, orange oil, cassia oil, methyl salicylate, eucalyptus oil, clove oil, γ-undecalactone, coriander oil, citrus oil, etc., especially Q-menthol, and peppermint oil, spearmint oil. , anethole, eucalyptus oil.

Essential oils such as citrus oil are effectively used.

According to the present invention, the use of paraoxybenzoic acid ester in combination with the above-mentioned polyoxyethylene/polyoxypropylene block polymerized nonionic surfactant effectively reduces the occurrence of cloudiness and ooze caused by the precipitation of these fragrances during low-temperature storage. The fragrance is solubilized in the oral composition even at low temperatures.

The blending amount of the fragrance is usually 0.01 to 5%, more preferably 0.1 to 1%.

The liquid transparent oral cavity composition according to the present invention is a mouthwash.

It can be prepared as a water toothpaste, a spray-type mouth freshener, etc. In this case, the ingredients of the liquid transparent oral composition, in particular, the appropriate commonly used ingredients depending on the type and purpose of use, etc. Ingredients can be blended.

For example, polyhydric alcohols such as polyethylene glycol, sorbitol, glycerin, propylene glycol, saccharin sodium, stevioside, neohesberidyl dihydrochalcone, glycyrrhizin, perillartin,
Sweeteners such as p-methoxycinnamic aldehyde, dextranase, mutanase, sorbic acid, alexidine, β-glycyrrhetinic acid, hinokitiol, and chlorhexidine.

Alkylglycine, alkyldiaminoethylglycine salt, allantoin, ε-aminocaproic acid, tranexamic acid, azulene, vitamin E, water-soluble primary or secondary phosphate, quaternary ammonium compounds such as cetylpyridinium chloride, sodium chloride, herbal medicines The oral composition of the present invention, in which one or more active ingredients such as extracts may be mixed, can be prepared by dissolving the above-mentioned ingredients in a solvent such as water or ethanol.

〔Effect of the invention〕

Since the fragrance-containing liquid transparent oral composition of the present invention is formulated by combining a polyoxyethylene/polyoxypropylene block polymerizable nonionic surfactant and a paraoxybenzoic acid ester, it does not become cloudy even when stored at low temperatures. can be prevented from occurring, and the effects of the polyoxyethylene/polyoxypropylene block polymerization type nonionic surfactant can be effectively exhibited.

Next, experimental examples will be shown to specifically explain the effects of the present invention.

[Experiment example]

Polyoxyethylene/polyoxypropylene block polymerization type (POE) in which the average degree of polymerization of polyoxyethylene is 196 and the average degree of polymerization of polyoxypropylene is 67.
-POP) A test solution having the composition shown in Table 1 using a nonionic surfactant was prepared, and after being left in a -5° C. constant temperature bath for 3 days, changes in appearance were visually determined. The test results are also listed in Table 1.

The criteria for judgment are as follows.

■Constant-base-! O: Transparent with no cloudiness or sludge.

X: There is cloudiness or ooze.

In addition, in the above table, the fragrance composition is as follows.

Q-Menthol 30.0% Peppermint oil 20.0 Spearmint oil 10.0 Anethole 10.0 Lemon oil 5.0 Orange oil 5.0 Cassia oil 1.0 Methyl salicylate 5.0 Eucalyptus oil 5.0 Clove oil 1. 0 Coriander oil 3.0 γ-Undecalactone 0.5 Total 100.0% Based on the results in Table 1, POE-POP nonionic surfactant was added. When the test liquid is not blended with fragrance, no cloudiness or ooze occurs even when stored at low temperature (No, 1), but when fragrance is added, turbidity or ooze occurs (No, 2 to 5). On the other hand, the test solutions (No. 6 to 10) that used a combination of POE-POP surfactant and paraoxybenzoic acid ester produced white cloudiness and ooze when stored at low temperatures even though they contained fragrance. It is observed that the transparent appearance is maintained.

EXAMPLES The present invention will be specifically explained below with reference to Examples, but the present invention is not limited to the Examples below.

The composition of the fragrance used in the following examples is as follows.

(Example 1) Mouthwash Pluronic F-1272.0% (manufactured by BASF Wyandotte) Methylparaben 0.2 Ethanol
3.0 glycerin 1
0.0 Flavor BO04 Sodium saccharin o, oos dextranase 500U/gO, 01M citric acid
・Total 100.0% [Example 2] Mouthwash Pluronic F-1271, 5% Methylparaben 0.1 Propylparaben 0.05 Ethanol
1.5 Glycerin 8.0 Fragrance AO03 Sodium saccharin 0.005 Mutanase 500U/gO,01M citric total 100.0% [Example 3] Mouthwash Pluronic F-1271.0% Pluronic F-1080.5 (BASF Wy (Manufactured by Andot) Methylparaben 0.1 Ethylparaben 0.05 Ethanol
1.0 Glycerin 10.0 Fragrance CO,4 Sodium saccharin 0.005Pigment 0.0003Dextranase 500U/gO,01M citric acid Total 100.0% (Example 4) Mouthwash Pluronic F-1271,0% Methylparaben 0.2 Ethanol 10.0 Glycerin 5.0 Fragrance B O,5 Sodium saccharin 0.006 Color
0.0002 Sodium benzoate 0.3 Benzethonium chloride 0.05 0.01M citric total 100.0% [Example 5] Mouthwash Pluronic F-1272, 0% Butyl paraben 07.2 Ethanol
8.0 Sorbitol 10.0 Fragrance C003 Sodium saccharin 0.005 Pigment 0.0003 Cetylpyridinium chloride 0.050.01M citric total 100.0% [Example 6] Washing liquid Pluronic F-1270, 8% Pluronic F -68 0.5 Propylparaben 0.1 Ethanol 12.0 Glycerin 12.0 Fragrance A 0.4 Sodium saccharin 0.006 Color
0.0003 Sodium benzoate 0.3 Tranexamic acid 0.05 0.01M citric total 100.0% [Example 7] Washing liquid Pronic F-1271.0 Methylparaben 0.2 Ethanol
5.0 Glycerin 1
0.0 Fragrance B O,2
Satucalin sodium 0.005 Sodium benzoate 0.3 Dipotassium glycyrrhizinate 0.05 0.01M citric total 100.0% [Example 8] Concentrated mouthwash Pluronic F-1271.5% Methylparaben 0.2 Propylparaben 0.05 ethanol
45.0 Glycerin 30.0 Fragrance C4,,Q Total 100.0% [Example 9] Mouth freshener Pluronic F-1273.5% Methylparaben 0.2 Propylparaben 0.1 Ethanol
40.0 Glycerin 15.0 Fragrance A
O,5

Claims (1)

[Claims] 1. A liquid transparent oral composition comprising a paraoxybenzoic acid ester blended into a liquid transparent oral composition containing a fragrance and a polyoxyethylene/polyoxypropylene block polymerizable nonionic surfactant.