JPH11209254A - Liquid composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition with high germicidal power and favorable appearance, useful for preventing periodontosis and dental caries, by making the composition include cetylpyridinium chloride and a specific polyoxyethylene cetyl ether to prevent the cetylpyridinium chloride from hampering its adsorption to the teeth surface. SOLUTION: This composition is obtained by including (A) pref. 0.001-0.5 wt.% of cetylpyridinium chloride and (B) pref. 0.1-1.5 wt.% of a polyoxyethylene cetyl ether with the number of addition moles of ethylene oxide of 10-30 (pref. 15-20) on average. This composition can be prepared to such formulations as mouthwash, dental rinse and dilution-type mouthwash.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an oral composition comprising a combination of cetylpyridinium chloride and polyoxyethylene cetyl ether. More specifically, the present invention prevents the inhibition of cetylpyridinium chloride from adsorbing to the tooth surface. The present invention relates to a liquid oral composition having excellent sterilizing power and good appearance.

[0002]

BACKGROUND OF THE INVENTION Plaque suppression is important for preventing periodontal disease and dental caries, and oral compositions containing a bactericide for the purpose of suppressing plaque are widely used. . Among these fungicides, cetylpyridinium chloride is widely used because it has a bactericidal effect on oral bacteria, a plaque suppressing effect, and a gingivitis improving effect. This mechanism of action of cetylpyridinium chloride is considered to prevent the formation of plaque because it adsorbs on the oral mucosa and the tooth surface and suppresses the action of bacteria.

As an oral composition actually containing cetylpyridinium chloride, JP-A-4-198120, JP-A-4-198120.
There is a known example described in JP-A-25734. In this oral composition, a fragrance is blended with cetylpyridinium chloride to improve bitterness and palatability, and a nonionic surfactant is simultaneously blended as an essential component for solubilizing the fragrance. However, when cetylpyridinium chloride and a nonionic surfactant are simultaneously added, a drawback has been heretofore known that the adsorptive power to the tooth surface is reduced, and as a result, the bactericidal power is reduced.

Therefore, Japanese Patent Application Laid-Open No. Hei 8-259428 discloses that 1/5 to alkyl quaternary ammonium compounds are used.
It has been found that by adding a 40-fold molar amount of cyclodextrins, the foaming property and the bactericidal action are excellent. However, since the liquid oral composition does not require excellent foaming properties, it is not necessary to incorporate a high concentration of a nonionic surfactant.

Japanese Patent Application Laid-Open No. 4-173728 discloses that the combination of cetylpyridinium chloride with a specific polyoxyethylene hardened castor oil does not inhibit the adsorption of cetylpyridinium chloride on the tooth surface. However, polyoxyethylene hardened castor oil produces insoluble 12-hydroxystearic acid, particularly when hydrolysis proceeds during high-temperature storage, and may impair the appearance stability.

In view of the above, the development of a liquid oral composition which prevents cetylpyridinium chloride from inhibiting adsorption to the tooth surface even in the presence of a nonionic surfactant, has an excellent bactericidal activity, and has a good appearance. Was desired.

[0007]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies to meet the above-mentioned demand, and as a result, it has been found that cetylpyridinium chloride and ethylene oxide have an average addition mole number of 10 to 30. By using oxyethylene cetyl ether in combination, it was found that inhibition of adsorption of cetylpyridinium chloride on the tooth surface was prevented, and a composition for liquid oral cavity having excellent bactericidal activity and good appearance was obtained.

Hereinafter, the present invention will be described in more detail. The oral composition of the present invention comprises cetylpyridinium chloride and polyoxyethylene cetyl ether in combination. In the present invention, the amount of cetylpyridinium chloride is not particularly limited.
01 to 0.5% (% by weight, the same applies hereinafter).

As the polyoxyethylene cetyl ether, a polyoxyethylene cetyl ether having an average degree of polymerization of ethylene oxide of 10 to 30 mol, preferably 15 to 20 mol is used. The amount of the polyoxyethylene cetyl ether is not particularly limited, but is usually 0.01 to 3%, preferably 0.05 to 2% of the whole oral composition.
%, More preferably 0.1 to 1.5%.

The oral composition of the present invention can be prepared into dosage forms such as a mouthwash, a dental rinse, and a diluted mouthwash. In addition to the above-mentioned components, various well-known components depending on the type of each component can be prepared. Can be blended within a range that does not impair the effects of the present invention. For example, wetting agents such as glycerin, sorbit, propylene glycol, ethylene glycol, polyethylene glycol, xylit, maltitol, lactit, saccharin, dipotassium glycyrrhizinate,
Sweeteners such as stevia extract, aspartame, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perillartin, menthol, carvone,
Flavors such as anethole, eugenol, methyl salicylate, thymol, limonene, spearmint oil, peppermint oil, lemon oil, orange oil, phthalic acid, phosphoric acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, carbonic acid and the like Buffers such as sodium, potassium and ammonium salts, preservatives such as sodium benzoate, paraoxybenzoate, lower fatty acid monoglyceride, p-hydroxymethylbenzoic acid, p-hydroxyethylbenzoic acid, ethanol, coloring matter, xanthan gum, Binders such as carrageenan, carboxymethylcellulose, hydroxyethylcellulose, sodium alginate, polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, and polyvinylpyrrolidone; glycine; Amino acids such as nin, serine, leucine, aspartic acid, and glutamic acid; fluorides such as sodium monofluorophosphate, sodium fluoride and stannous fluoride; enzymes such as dextranase, amylase, protease, mutanase, and lysozyme; Acid, ε-aminocaproic acid, allantoinate, glycyrrhizinate salts, anti-inflammatory agents such as dipotassium glycyrrhizinate, condensed phosphates such as sodium phosphate, sodium pyrophosphate, sodium tripolyphosphate, sodium tetrapolyphosphate, sodium chloride, etc. Active ingredients such as inorganic salts, plant extracts such as clove, rosemary, thyme, and goug can be blended.

[0011]

EFFECTS OF THE INVENTION The oral composition of the present invention prevents cetylpyridinium chloride from inhibiting adsorption to the tooth surface, has excellent bactericidal activity and good appearance.

[0012]

EXAMPLES Hereinafter, the effects of the present invention will be specifically described with reference to experimental examples and examples, but the present invention is not limited to the following examples.

[Experimental Example 1] 1 g of powdered apatite is shown in Table 1.
After 10 mL of the evaluation sample shown in (1) was stirred and immersed at 37 ° C. for 1 hour, 5 mL of the supernatant was collected, and cetylpyridinium chloride was quantified by liquid chromatography. The liquid chromatograph uses acetonitrile
The phosphate buffer was measured at an absorbance of 265 nm using an ODS column (4 mmφ × 150 mm) under the condition of 1.2 mL / min. Table 1 shows the results.

[0014]

[Table 1]

From Table 1, it can be seen that the adsorption of cetylpyridinium chloride to apatite powder tends to be inhibited by sodium lauryl sulfate, but the nonionic surfactants polyoxyethylene (20) cetyl ether and polyoxyethylene (60 ) Hardened castor oil was found not to inhibit, and of the three types, polyoxyethylene (20) cetyl ether was found not to inhibit the adsorption to apatite most.

[Experimental Example 2] The amount of cetylpyridinium chloride adsorbed on powdered apatite was measured under the same conditions as in Experimental Example 1 except that the number of moles of ethylene oxide added to polyoxyethylene cetyl ether was changed. Table 2 shows the results.

[0017]

[Table 2]

From Table 2, it is found that the number of moles of added ethylene oxide is 5
In the case of, a preparation having a good appearance could not be prepared. Conversely, when the number of moles of added ethylene oxide was 40, the amount of cetylpyridinium chloride adsorbed tended to decrease.

Experimental Example 3 Polyoxyethylene (20)
To compare the appearance stability of cetyl ether and polyoxyethylene (60) hydrogenated castor oil, samples were prepared with the following composition. <Ingredients> ethanol 1% by weight glycerin 5 sodium saccharin 0.01 cetylpyridinium chloride 0.05 fragrance 0.4 nonionic surfactant 3 purified water balance 100.0% by weight

Each of the prepared samples was stored at 40 ° C. for 3 months, and the appearance stability at 5 ° C. was determined according to the following evaluation criteria. Table 3 shows the results. ：: Good transparency, no turbidity observed. X: Poor transparency and turbidity observed.

[0021]

[Table 3]

Example 4 Mouthwash Ethanol 10.0% by weight Glycerin (85%) 10.0 Citric acid 3.0 Sodium citrate 6.0 Sodium fluoride 0.2 Sodium saccharin 0.1 Sodium benzoate 0 .2 dye 0.0002 fragrance 0.2 cetylpyridinium chloride 0.05 polyoxyethylene (30) cetyl ether 0.2 purified water balance 100.0% by weight

Example 5 Diluent Mouthwash Ethanol 40.0% by weight Glycerin (85%) 30.0 Saccharin sodium 0.5 Fragrance 3.0 Cetylpyridinium chloride 5.0 Polyoxyethylene (10) cetyl ether 3 0.0 purified water balance 100.0% by weight

Example 6 Oral Preparation Ethanol 40.0% by weight Glycerin (85%) 10.0 Saccharin sodium 0.1 Sodium benzoate 0.3 Fragrance 5.0 Cetylpyridinium chloride 0.01 Polyoxyethylene (15) Cetyl ether 1.0 Purified water Balance 100.0% by weight

All of the compositions of Examples 4 to 6 prevent cetylpyridinium chloride from inhibiting adsorption to the tooth surface and have good appearance.

Claims (1)

[Claims] 1. A liquid oral composition comprising cetylpyridinium chloride and polyoxyethylene cetyl ether having an average addition mole number of ethylene oxide of 10 to 30.