JP2001233750A - Liquid composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a liquid composition, such as a liquid tooth dentifrice or a mouth wash solution, which is used for oral cavities and contains shellac and a pigment in such an amount as maintaining the transparency of the composition to give a clean appearance or a refreshing appearance to the commodity, and which can make the brown color of the shellac quiet. SOLUTION: This liquid composition for oral cavities contains shellac, a pigment in an amount of 0.1 to 10 mg/liter, and a chelating agent as a discoloration-preventing component. The chelating agent is preferably an edetate, a phytate or a polyphosphate.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid oral composition which is easy to use and can protect the tooth surface from acids which cause dental caries. The present invention relates to a high liquid oral composition having excellent commercial value.

[0002]

2. Description of the Related Art Conventionally, dentifrices and mouthwashes contain medicinal ingredients such as bactericides and anti-inflammatory agents, abrasives such as calcium carbonate, and fragrances and colorings.
They have been widely used by people to keep their mouth clean and their teeth healthy. However, in recent years, along with changes in the sense of cleanliness, toothpastes and mouthwashes not only contribute to the health aspects described above, but also whiten and gloss the teeth. It is becoming desirable to have a multi-functionality such as the ability to do so. To satisfy such demands, for example, dentifrices containing a phosphate compound or hydroxyapatite have been studied.

In order to obtain a liquid oral composition having an action of protecting the tooth surface from the acid which is said to cause tooth decay, the present inventors dissolve shellac in a solvent mainly composed of water. (Japanese Patent Application Laid-Open No. 11-147814).

[0004]

However, it has been found that when shellac is incorporated into a liquid dentifrice or mouthwash, the formulation tends to brown over time due to shellac. To prevent this, the appearance is masked if it is strongly colored, but it is not suitable for a mouthwash or the like because it impairs the commercial value. Therefore, the present invention relates to a liquid dentifrice or mouthwash containing a shellac, and a pigment to such an extent that the product is kept transparent so as to have a clean feeling or a refreshing feeling. An object of the present invention is to provide a composition for a liquid oral cavity that can make browning of a liquid less noticeable.

[0005]

Means for Solving the Problems The present inventors have conducted various studies in order to solve the above-mentioned problems, and have made a liquid oral composition containing a shellac and a dye less noticeable in browning of the formulation by the shellac. Investigation of the relationship between the type and concentration of the dye that can be performed and additives that prevent browning, etc., revealed that adding a chelating agent to the colored liquid oral composition makes the browning due to shellac less noticeable. The present invention was completed by examining the conditions and the like of a chelating agent capable of making browning by shellac inconspicuous in relation to the concentration of the dye and the like on the basis thereof.

The present invention has solved the above-mentioned problems by the following means. (1) Shellac and 0.1 mg / liter or more and 10 mg
A composition for a liquid oral cavity, comprising a pigment of less than 1 / liter and containing a chelating agent as a discoloration preventing component. (2) The liquid oral composition according to the above (1), wherein an edetate, a fintinate, or a polyphosphate is used as the chelating agent.

[0007] Specific examples of the liquid oral composition of the present invention include mouthwashes, mouth fresheners and the like. The shellac used in the present invention is a resinous substance obtained by purifying a secretion covering the body of the raccoon bug described in the Japanese Pharmacopoeia and the like, and is a purified shellac or white shellac that has been bleached. There may be. The liquid oral composition of the present invention requires that the medium is water or water-based in relation to application to the human oral cavity, but shellac is almost soluble in water. Since the substance is not present, if the medium is only water, it will exist as a non-uniform dispersion state, and will not perform an effective operation. Shellac is soluble in alcohol. For this reason, when shellac is used to manufacture the above-mentioned product, it is preferable to use a liquid product in which shellac is dissolved as much as possible as a water-alcohol-based medium of shellac. As the alcohol, not only a monohydric alcohol such as ethanol but also a polyhydric alcohol such as sorbitol and glycerin can be used. The alcohol must of course be harmless to the human body.

For this reason, the liquid oral composition of the present invention comprises:
Shellac may be dissolved in a solvent mainly composed of water. As a result, it was possible to obtain a liquid oral composition containing shellac, which does not require brushing and only needs to be rinsed in the oral cavity. In the present invention, the presence of shellac dissolved in a solvent means that shellac is uniformly present in a solvent mainly composed of water, and in a broad sense, dispersed in a solvent. It may be in an emulsified or solubilized state. Visually speaking, it is sufficient that the film is transparent and no cloudiness or scum is observed. The above “dispersion, emulsification” and the like preferably satisfy this state.

The liquid oral composition of the present invention contains a pigment for commercialization by dissolving shellac in a solvent mainly composed of water, and contains a pigment for commercialization. It is less than 0.1 mg / liter or less. As the dye, those which are legal dyes are used, and specific examples of the legal dye include nitro dyes, azo dyes, nitroso dyes, triphenylmethane dyes, quinoline dyes, anthraquinone dyes, indigo dyes, and the like. Among them, water-soluble ones are preferred. Specific examples include Blue No. 1, Yellow No. 4, Red No. 102, Green No. 201, and the like. The coloring by the content of the pigment is insufficient to make the browning of the liquid oral composition by shellac inconspicuous, but when the pigment is contained in an amount larger than that, the color of the liquid oral composition becomes deeper. The content of the pigment is 10 mg /% because the composition may be unfavorable as a product and may cause discomfort, and when the liquid oral composition is put into the mouth, the mouth may appear to be slightly colored.
Must be less than a liter. Then, it was found that the addition of a chelating agent was effective for making the browning of the liquid oral composition by shellac less noticeable within the range of the content of the pigment.

As the chelating agent, those generally used, for example, sodium tripolyphosphate, sodium pyrophosphate, disodium edetate (EDTA · 2N)
a), phytic acid and the like, and particularly preferred are sodium pyrophosphate and EDTA · 2Na. The amount of the chelating agent to be added is to make the browning due to shellac less noticeable in the above-mentioned colored liquid oral composition, so that a considerably small amount is sufficient.
For example, in a colored liquid oral composition having a pigment content of less than 10 mg / l, when the shellac content is 1 to 10 g / l, the chelating agent content is 0.1 to 1. The concentration can be 0 g / liter, and the concentration range varies depending on the type of the chelating agent.

[0011]

BEST MODE FOR CARRYING OUT THE INVENTION In order to obtain such a liquid oral composition, shellac is dissolved in an alcohol such as ethanol, and sodium hydroxide or the like is added to the resulting solution to make it a strong alkali. However, since it is highly irritating when applied to the oral cavity as it is, it is preferable that the pH is adjusted to a neutral or weak alkalinity with sodium phosphate or the like, for example, a pH of about 7.0 to 9.0. Further, shellac may be directly added to a strong alkaline aqueous solution without using alcohol. In this case, there is a disadvantage that it takes time to dissolve, but the same can be obtained.

The solvent of the present invention preferably has the largest amount of water in the solvent contained in the liquid oral composition. For example, the amount of water contained in the solvent is usually 50 to 95. The percentages by weight are indicated. Other solvents, such as alcohols, may be included in smaller amounts than water. For example, the amount of alcohol contained in the solvent is usually 0
-30% by weight are indicated. As the solvent, water such as purified water or ionized water, alcohol such as ethanol or various denatured alcohols can be used, and the solvent does not contain harmful components such as methanol. Various components applicable to the oral cavity, such as a bactericide, an anti-inflammatory agent, a fragrance, a detergent, a wetting agent, and the like, can be added to the liquid oral composition of the present invention. As these, conventionally known ones can be used as long as they do not reduce the feeling of use or impair the effects of the invention. Examples of such components are shown below.

[0013] As disinfectants, decalinium chloride, benzethonium chloride, benzalkonium chloride, cetylpyridinium chloride, alkyldiaminoethylglycine hydrochloride, chlorhexidine hydrochloride, chlorhexidine gluconate,
Anti-inflammatory agents such as triclosan and isopropylmethylphenol include anti-inflammatory agents such as aminocaproic acid, allantoin and its derivatives, glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, ascorbic acid and its salts, vitamin E (tocopherol) and lysozyme chloride In addition, as a substance having a tooth surface strengthening action, a source of fluoride ions such as sodium fluoride, fluorophosphate and fluoroborate, a source of phosphate ions such as calcium phosphate and hydroxyapatite, humidification of glycerin, propylene glycol, sorbite, etc. Agents, foaming agents such as sodium lauryl sulfate, steviaside, xylitol, erythritol, sorbitol,
Sweeteners such as saccharin sodium, preservatives such as parahydroxybenzoate and sodium benzoate,

Polyoxyethylene hydrogenated castor oil, polyoxyethylene / polyoxypropylene block polymer, polyoxyethylene / polyoxypropylene alkyl ether, polyoxyethylene / alkyl ether,
Polyoxyethylene alkylphenyl ether, polyoxyethylene fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, sorbitan fatty acid ester, poly Non-ionic surfactants such as oxyethylene sorbitan monolaurate, glycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester,

Sodium lauryl sulfate, sodium myristyl sulfate, polyoxyethylene alkyl ether sulfate, sodium lauroyl sarcosine, myristoyl sarcosine sodium, alkyl ether carboxylate, alkyl phosphate, polyoxyethylene alkyl ether phosphate, N- Anionic surfactants such as acyltaurine salt, polyoxyethylene alkyl ether phosphate / phosphate, sulfonate, alkyltrimethylammonium chloride, dialkyldimethylammonium chloride, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, poly Cationic surfactants such as oxyethylene alkylamine and fatty acid amide,

In addition, dextranase, mutanase, glycyrrhizinate and its derivatives, glycyrrhetinate and its derivatives, azulene, azulene sulfonic acid, dihydrocholesterol, epidihydrocholesterin, ouba extract, tomato soft extract, hinokitiol, allantoin , Allantoinchlorohydroxyaluminum, sodium chloride, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, epsilon aminocaproic acid, tranexamic acid, polyphosphate,
Thymol, copper chlorophyllin sodium, wax and other flavors such as peppermint oil, peppermint oil, menthol,
Carvacrol, eucalyptus oil, eugenol, etc.

When the above-mentioned bactericides and / or anti-inflammatory agents are used, the above-mentioned chelating agents also act to increase their stability. The liquid oral composition of the present invention can be used as a mouthwash or a mouthwash by including an appropriate amount in the oral cavity and washing the mouth. In addition, it can be used as a liquid dentifrice including those prepared by blending abrasives such as calcium hydrogen phosphate, aluminum hydroxide, silicic acid anhydride and calcium carbonate as needed.

[0018]

EXAMPLES Hereinafter, the present invention will be described in detail with reference to examples, but the present invention is not limited to these examples.

Example 1 (Preparation of Liquid Oral Composition) Various chelating agents and dyes shown in Table 2 were blended in the basic formulation shown in Table 1 to obtain a total of 1
A liquid oral composition was prepared in the amount of 00 ml. In this example, Blue No. 1 was used as a dye. For comparison, a liquid oral composition containing no chelating agent (Comparative Example) was prepared.

(Aging stability test) Test Method The composition for liquid oral cavity prepared as described above was kept at 40 ° C. for 6 months, and the degree of color change after the lapse was evaluated on a three-point scale.
The color difference of a part of the composition was measured. 2. Measurement method The degree of color change after storage at 40 ° C. was visually determined. 3. Evaluation Criteria The evaluation criteria for the change in color are as follows. ○: no change △: slight change ×: significant change

4. Measurement results Table 2 shows the measurement results. As can be seen from Table 2, each of the liquid oral compositions of the present invention to which a chelating agent was added prevented discoloration as compared with a comparative liquid oral composition to which no chelating agent was added. When the amount of the pigment is 10 mg / liter, the color change is indistinct because the color is deep, but it is considered that the palatability as a mouthwash and a liquid dentifrice is inferior. However, it was found that the discoloration can be prevented by adding a chelating agent at a dye amount of 1 to 5 mg / liter, which is considered to be preferable. The colorless one containing a chelating agent has a smaller degree of discoloration than the one containing no chelating agent.

[0022]

[Table 1]

[0023]

[Table 2]

[0024]

According to the present invention, a liquid dentifrice or mouthwash containing a shellac and a pigment to such an extent that the product is kept transparent so that the product has a clean feeling or a cool feeling. And the like, a liquid oral composition that can make browning by shellac less noticeable is obtained. In this liquid oral composition, since it also has the effect of protecting the tooth surface from the acid that is said to be the cause of tooth decay, it is possible to make browning over time due to the shellac being compounded, Product value can be increased. Also,
The liquid oral composition of the present invention is simple to use, and can provide a colored, high commercial value liquid oral composition that can protect the tooth surface from the acid that causes tooth decay.

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Claims (2)

[Claims] 1. A liquid oral composition comprising shellac and a pigment of 0.1 mg / liter or more and less than 10 mg / liter, and containing a chelating agent as a discoloration preventing component. 2. The liquid oral composition according to claim 1, wherein an edetate, a fintinate, or a polyphosphate is used as the chelating agent.