JPH07187973A - Liquid composition for oral cavity - Google Patents

Abstract

PURPOSE:To obtain a liquid composition for oral cavity capable of preventing development of mold and giving pleasant feeling in use by blending a liquid composition for oral cavity having a specific amount of an ethanol content with a mildew-proofing component. CONSTITUTION:This composition for oral cavity is obtained by blending a liquid composition for oral cavity not containing ethanol or containing <=3wt.% of ethanol with one or two or more compounds selected from cinnamic aldehydes of formula I {R<1> to R<5> each is a 1-3C alkyl, a 2-3C alkenyl, H, OH, methoxy or ethoxy or adjacent two R<n> groups [(n) is 1-5] form O or CH2O}, acetals of cinnamic aldehydes of formula II (R<6> and R<7> each is a 1-3C alkyl or a 2-3C alkenyl or R<6> and R<7> form formula III, etc.), aliphatic aldehydes of the formula R<8>-CHO (R<8> is a 5C alkyl or alkenyl), acetals of aliphatic aldehydes of formula IV and hinokitiol. The composition is used as a mouth- washing agent, a liquid dentifrice, a mouth refreshing agent, etc.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to liquid oral compositions containing no or low ethanol content.

[0002]

2. Description of the Related Art Liquid oral compositions such as mouth rinses usually contain ethanol at 3% (weight%, below) for the purpose of giving a feeling of use and avoiding problems of low temperature solidification. Same as above), but do not add ethanol or reduce ethanol content from the viewpoint of ensuring safety in case of accidental ingestion by infants and ensuring stability of enzyme when an enzyme is added as an active ingredient. Is desired.

However, in a liquid oral composition which does not use ethanol or a liquid oral composition which uses only a small amount of ethanol, there is a case where mold deficiency is insufficient due to lack of ethanol, and mold may occur over time. Therefore, the solution of this point was desired.

In this case, the liquid oral composition contains several kinds of bactericides, among which sodium benzoate, para-hydroxybenzoic acid ester and the like are widely used. However, these bactericides have a high antibacterial effect against bacteria, but have a weak antifungal effect against mildew. Therefore, a liquid oral composition containing these bactericidal agents is difficult to obtain sufficient antifungal power.

On the other hand, cetylpyridinium chloride (C
Although bactericides such as PC) and quaternary cation salts have a strong mildew-proofing power, they have a problem that they have a strong off-taste and are inferior in usability. In addition, when compounded in a liquid oral composition containing an enzyme as an active ingredient, the stability of the enzyme is impaired.

The present inventor has been made in view of the above circumstances, and an object of the present invention is to provide a liquid oral composition capable of imparting a sufficient level of mildew-proofing power without impairing the feeling of use. .

[0007]

MEANS TO SOLVE THE PROBLEMS As a result of intensive studies aimed at achieving the above object, the present inventor has found that cinnamic aldehydes represented by the following structural formula (1) and structural formula (2) below.
The cinnamic aldehyde acetals, the aliphatic aldehydes of the following structural formula (3), the aliphatic aldehyde acetals of the following structural formula (4), and hinokitiol do not contain ethanol or contain only a small amount of ethanol. An excellent antifungal effect is exerted on a composition, specifically, a liquid oral composition having an ethanol content of 3% or less, and a mold is surely generated in spite of containing no ethanol or a small amount of ethanol. It was found that the above-mentioned antifungal component does not impair the feeling of use of the liquid oral composition, and has accomplished the present invention.

[0008]

[Chemical 4] (Wherein R ^{1 to} R ⁵ are each an alkyl group having 1 to 3 carbon atoms, an alkenyl group having 2 to 3 carbon atoms, a hydrogen atom, a hydroxyl group, a methoxy group, or an ethoxy group, or two adjacent R ⁿ ( (n = 1 to 5) represents a group forming —O—CH ₂ —O—, except when all of R ^{1 to} R ⁵ are hydrogen atoms.)

[0009]

[Chemical 5]

R ⁸ —CHO (3) (In the above formula, R ⁸ represents an alkyl group or an alkenyl group having 5 carbon atoms.)

[0011]

[Chemical 6] (In the above formula, R ⁶ , R ⁷ and R ⁸ have the same meanings as above.)

Therefore, the present invention has an ethanol content of 3
A liquid oral composition containing less than 1% by weight of a cinnamic aldehyde represented by the above structural formula (1) as a fungicide,
Selected from the cinnamic aldehyde acetals represented by the structural formula (2), the aliphatic aldehydes represented by the structural formula (3), the aliphatic aldehyde acetals represented by the structural formula (4), and hinokitiol. 1
Provided is a composition for liquid oral cavity, which is characterized by being mixed with two or more kinds.

The present invention will be described in more detail below. The liquid oral composition of the present invention has an ethanol content of 0.
-3%, especially 0-2%, and the present invention provides the liquid oral composition with cinnamic aldehydes represented by the following structural formula (1) as antifungal components and represented by the following structural formula (2). One or more selected from cinnamic aldehyde acetals, aliphatic aldehydes represented by the following structural formula (3), aliphatic aldehyde acetals represented by the following structural formula (4), and hinokitiol. It is a mixture.

[0014]

[Chemical 7] (Wherein R ^{1 to} R ⁵ are each an alkyl group having 1 to 3 carbon atoms, an alkenyl group having 2 to 3 carbon atoms, a hydrogen atom, a hydroxyl group, a methoxy group, or an ethoxy group, or two adjacent R ⁿ ( (n = 1 to 5) represents a group forming —O—CH ₂ —O—, except when all of R ^{1 to} R ⁵ are hydrogen atoms.)

[0015]

[Chemical 8]

R ⁸ —CHO (3) (In the above formula, R ⁸ represents an alkyl group or an alkenyl group having 5 carbon atoms.)

[0017]

[Chemical 9] (In the above formula, R ⁶ , R ⁷ and R ⁸ have the same meanings as above.)

Examples of the compounds of the above formulas (1) to (4) are o-methoxycinnamic aldehyde, p
-Methoxycinnamic aldehyde, p-ethoxycinnamic aldehyde, 3,4-dimethoxycinnamic aldehyde, 3,4,5-trimethoxycinnamic aldehyde, cinnamic aldehyde-dimethyl acetal, cinnamic aldehyde-diethyl acetal, cinnamic Aldehyde-propylene glycol acetal, p-methoxycinnamic aldehyde-diethyl acetal, p-methoxycinnamic aldehyde propylene glycol acetal, p-methoxycinnamic aldehyde dimethyl acetal, hexanal, t-2
-Hexenal, cis-3-hexenal, t-2-
Examples include hexenal dimethyl acetal, t-2-hexenal diethyl acetal, t-2-hexenal propylene glycol acetal, and the like.

The amount of the above-mentioned cinnamic aldehyde compounded is preferably 0.0001 to 0.5%, more preferably 0.001 to 0.05% of the total composition. The amount of acetals of cinnamic aldehyde is preferably 0.0002 to 0.5% of the total composition, and more preferably 0.002 to 0.1%. Furthermore, the compounding amount of the aliphatic aldehydes is 0.0000.
5 to 0.1%, particularly 0.0001 to 0.05%, and the compounding amount of the acetal of the aliphatic aldehyde is 0.0001 to
0.2%, particularly 0.0002 to 0.1%, and the amount of hinokitiol compounded is 0.0001 to 0.1%, especially 0.000.
It is preferably 5 to 0.01%. In any case, if the compounding amount is small, the antifungal effect is not sufficiently exhibited, and if it is too large, the usability may be impaired.

The liquid composition for oral cavity of the present invention is used as a mouthwash, a toothpaste, a refreshing agent in the mouth and the like, and various components may be blended if necessary.

For example, dextranase, amylase,
Enzymes such as protease, mutanase, lysozyme, lytic enzyme, sodium monofluorophosphate, sodium fluoride, fluorides such as stannous fluoride, chlorhexidine salts, epsilon aminocaproic acid, aluminum chlorhydroxyl allantoin, dihydrocholesterol, glycyrrhizin salts, One or more kinds of water-soluble phosphoric acid compounds such as sodium chloride, potassium salt of orthophosphoric acid and sodium salt, azulene and vitamins can be blended. In addition, the compounding amount of the above-mentioned active ingredient can be a usual amount as long as the effect of the present invention is not impaired.

In the liquid oral composition of the present invention,
Other perfume ingredients such as 1,8-cineole, anethole, eugenol, methyl salicylate, linalool, menthol and limonene, and essential oils may be added within a range that does not affect the effects of the present invention.

In this case, the liquid oral cavity composition of the present invention preferably contains 1-menthol, and the antifungal effect is further synergistically enhanced by using 1-menthol as the antifungal component. . In this case, the blending amount of 1-menthol is 0.005 to 1%, especially 0.01 to 1% of the whole composition.
It is preferably 0.5%.

The liquid composition for oral cavity of the present invention may further contain various components, if necessary. Specifically, as a viscous agent, sorbit, glycerin, propylene glycol,
One or two or more kinds of 1,3-butylene glycol, polyethylene glycol, xylit, maltite, lactit and the like can be blended, and sodium carboxymethyl cellulose, carrageenan, sodium alginate, polyacrylic acid and salts thereof, and gums can be used as a binder. , Polyvinyl alcohol, hydroxyethyl cellulose and the like may be added alone or in combination. Further, sodium lauryl sulfate, lauroyl sarcosinate, α-olefin sulfonate, taurate, lauryl monoglyceride sulfate, lauryl monoglyceride sulfonate,
N-long-chain acyl amino acid salts, anionic activators such as soap, lauric acid diethanolamide, stearyl monoglyceride, sucrose fatty acid ester, lactose fatty acid ester, lactitol fatty acid ester, maltitol fatty acid ester, polyoxyethylene sorbitan monostearate, etc. One or more surfactants such as nonionic surfactants, polyglycerin fatty acid esters, betaine-type and amino acid-type amphoteric surfactants may be blended.

Furthermore, sweeteners such as sodium saccharin, stevioside, neohesperidyl dihydrochalcone, thaumatin, glycyrrhizin and perillartin, preservatives such as paraben and sodium benzoate, and other ingredients may be added, and the above-mentioned desired ingredients may be added. It can be produced by kneading with an appropriate amount of water. In this case, the water content is usually 50 to 95%, especially 70 to 90%.

[0026]

Industrial Applicability The liquid oral composition of the present invention does not contain ethanol or has an excellent antifungal property at least in the content of ethanol, and has a good feeling in use.

[0027]

EXAMPLES The present invention will be specifically described below with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples.

[Examples 1 to 4 and Comparative Examples 1 to 4] Mouthwashes were prepared based on the compositions shown in Table 1 and evaluated for antifungal activity and usability. Anti- mildew measuring method To 1 ml of the prepared mouthwash, mold (Paecilomyce)
s variotii) inoculated with about 10 ⁵ and kept at 25 ° C for 4
The number of remaining bacterial cells after weekly culture was measured. ◯: Residual bacterial cell number is 10 cells / ml or less Δ: Residual bacterial cell number is 10 to 1000 cells / ml ×: Residual bacterial cell number is 1000 cells / ml or more Evaluation method of feeling Prepared by a 14-member specialized panel The taste when the mouthwash was used was evaluated on a 5-point scale, and the average value of the scores of the panels of 14 obtained was applied to the following criteria to evaluate the feeling of use. <Rating> 5 points: No off-flavor and off-odor 4 points: Slight off-taste and off-flavor 3 points: Slight off-taste off-flavor 2 points: Off-taste off-flavor 1 point: Strong off-taste off-flavor <Evaluation criteria> ○: 5 points △: 3-4 Point x: 2 points or less

[0029]

[Table 1] * Fragrance: 1-menthol in the fragrance has a content of 40% in the fragrance and 0.04% in the composition.

Example 5 Liquid Toothpaste Glycerin (85%) 34.0% Propylene Glycol 5.0 Sodium Polyacrylate 3.5 Sodium Lauryl Sulfate 1.0 Ethanol 3.0 Hinokitiol 0.01 1-Menthol 1. 0 Saccharin sodium 0.08 Cineol 0.5 Purified water Residual total 100.0%

[Example 6] Mouthwash Disodium phosphate 0.3% Citric acid 0.3 Glycerin (85%) 15.0 Ethanol 2.0 Sodium lauryl sulfate 0.5 p-Dimethoxycinnamic aldehyde 01 Diethyl acetal Peppermint oil 0.5 Melon flavor 0.01 Anethole 0.05 Saccharin sodium 0.05 Purified water Residual 100.0%

Example 7 Mouthwash Ethanol 2.0% Polyoxyethylene hydrogenated castor oil 0.5 t-2-hexenal diethyl acetal 0.005 1-menthol 0.4 anethole 0.1 spearmint oil 0.1 Methyl salicylate 0.05 Blueberry flavor 0.01 Stevioside 0.1 Purified water Residual 100.0%

Example 8 Oral Coolant (Liquid) Ethanol 1.0% Polyoxyethylene hydrogenated castor oil 3.0 Glycerin (95%) 15.0 p-Methoxycinnamic aldehyde 0.01 1-Menthol 1. 0 anethole 0.2 stevioside 0.5 purified water balance 100.0%

Claims (1)

[Claims] 1. A liquid oral composition having an ethanol content of 3% by weight or less, and a cinnamic aldehyde represented by the following structural formula (1) as a fungicide, and the following structural formula (2).
One or more selected from cinnamic aldehyde acetals represented by, aliphatic aldehydes represented by the following structural formula (3), aliphatic aldehyde acetals represented by the following structural formula (4), and hinokitiol. A composition for a liquid oral cavity, which comprises: [Chemical 1] (Wherein R ^{1 to} R ⁵ are each an alkyl group having 1 to 3 carbon atoms, an alkenyl group having 2 to 3 carbon atoms, a hydrogen atom, a hydroxyl group, a methoxy group, or an ethoxy group, or two adjacent R ⁿ ( n = 1 to 5) represents a group forming —O—CH ₂ —O—, except for the case where all of R ^{1 to} R ⁵ are hydrogen atoms. R ⁸ —CHO (3) (In the above formula, R ⁸ represents an alkyl group or an alkenyl group having 5 carbon atoms.) (In the above formula, R ⁶ , R ⁷ and R ⁸ have the same meanings as above.)