JP2007106728A - Ethanol-free liquid oral composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an ethanol-free liquid oral composition exerting excellent systemic bactericidal effect to periodontal disease primitive biofilm, having good external stability at low and high temperatures, hardly stimulating and effective for preventing and improving intraoral diseases. <P>SOLUTION: The ethanol-free liquid oral composition comprises (A) isopropylmethyl phenol, (B) propylene glycol and/or glycerol, (C) at least one nonionic surfactant selected from a polyoxyethylene-cured castor oil of 40-100 moles average addition number of ethylene oxide, and a 16-18C chain length polyoxyethylene alkyl ether of 10-40 moles average addition number of ethylene oxide, and (D) at least one water-soluble polymer compound selected from sodium carboxymethyl cellulose, carrageenan, and hydroxyethyl cellulose. And the above-mentioned ethanol-free liquid oral composition containing (E) triclosan is provided. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a low-stimulation ethanol-free liquid oral composition that exhibits an osmotic and bactericidal effect on periodontopathic biofilms and has good appearance stability at low and high temperatures.

  Conventionally, the causes of caries, gingivitis, periodontitis and bad breath are considered to be caused by various bacteria in plaque. Plaque control, that is, oral bacteria, is an effective means for prevention and improvement of oral diseases. It is said that it is useful to keep the number low.

  As a means of reducing the number of pathogenic bacteria in the oral cavity, it is effective to add a nonionic bactericidal agent or a cationic bactericidal agent to an oral care product, and in particular, it is added to an oral care product. Among the bactericides, nonionic bactericides such as isopropylmethylphenol have characteristics that tend to have a broad antibacterial spectrum compared to cationic bactericides, and are therefore incorporated in several oral compositions and marketed. Has been.

  However, these nonionic disinfectants are oil-soluble compounds and are hardly soluble in water as they are, so they are solubilized by blending various surfactants and solvents such as ethanol. In order to inactivate the active site of the bactericidal agent, sufficient bactericidal power is not expressed when the blending amount increases, and when the blending amount of the surfactant is decreased to improve bactericidal power, It is known that there is a problem that the liquid becomes cloudy and the appearance stability of the composition is impaired.

  On the other hand, the blending of ethanol used as a solubilizing solvent causes a spicy irritating feeling when using the oral composition, and in recent years, non-alcohol mouthwashes that do not contain ethanol have been widely used. However, a liquid oral composition containing a nonionic disinfectant containing no ethanol requires a solubilizing power by a surfactant rather than the case of adding ethanol. It was more difficult to achieve both the external appearance stability at the same time.

  Heretofore, in the technology for preventing oral disease by using isopropylmethylphenol, isopropylmethylphenol is solubilized with low-concentration POE hydrogenated castor oil (Patent Document 1; Japanese Patent Laid-Open No. 1-305021). , Patent Document 2: Japanese Patent Laid-Open No. 7-48237, Patent Document 3; Japanese Patent Laid-Open No. 10-330230), and these compositions all contain ethanol and have a problem of high irritation.

JP-A-01-305021 Japanese Patent Application Laid-Open No. 07-048237 Japanese Patent Laid-Open No. 10-330230

  The present invention has been made in view of the above circumstances, exhibits an osmotic sterilizing effect on periodontopathic biofilms, has good appearance stability at low and high temperatures, and is a low-stimulation ethanol-free liquid oral composition. The purpose is to provide.

  As a result of intensive studies to achieve the above object, the present inventor has a liquid oral composition containing isopropylmethylphenol as a bactericidal component, and has an average added mole number of propylene glycol and / or glycerin and ethylene oxide. At least one nonionic surfactant selected from 40 to 100 moles of polyoxyethylene hydrogenated castor oil and a polyoxyethylene alkyl ether having a carbon chain length of 16 to 18 and an average added mole number of ethylene oxide of 10 to 40 moles; In addition, by using at least one water-soluble polymer compound selected from sodium carboxymethylcellulose, carrageenan, and hydroxyethylcellulose, a high penetrating and bactericidal effect on periodontopathic biofilms is exhibited, and at low temperatures and When storing at high temperatures However, the appearance stability is good and a low-stimulation ethanol-free liquid oral composition can be obtained, and further, by adding triclosan to this liquid oral composition, the bactericidal effect against floating bacteria can be improved. I found.

  According to the present invention, the liquid oral composition containing isopropylmethylphenol is formulated with a combination of the specific components described above, and is an ethanol-free composition with excellent bactericidal power against oral bacteria and low and high temperatures. It was found that a high-quality liquid oral composition excellent in the prevention and improvement effect of oral diseases can be obtained, which is compatible with excellent appearance stability over time during storage, and the present invention is made. It has come.

Therefore, the present invention
(A) isopropylmethylphenol,
(B) propylene glycol and / or glycerin,
(C) From polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100 moles and a polyoxyethylene alkyl ether having a carbon chain length of 16 to 18 and an average addition mole number of ethylene oxide of 10 to 40 moles At least one nonionic surfactant selected,
(D) An ethanol-free liquid oral composition comprising at least one water-soluble polymer compound selected from sodium carboxymethylcellulose, carrageenan, and hydroxyethylcellulose; and (E) triclosan An ethanol-free liquid oral composition is provided.

  The composition for liquid oral cavity containing no ethanol of the present invention exhibits an excellent osmotic bactericidal effect on periodontopathic biofilms, has good low-temperature and high-temperature appearance stability, and is mild. It is effective for the prevention and improvement of oral diseases such as periodontitis, gingivitis, bad breath and the like, and it is also useful for children and the like because it contains no ethanol and has low irritation.

  Hereinafter, the present invention will be described in more detail. The liquid oral composition of the present invention contains (A) isopropylmethylphenol as a bactericidal component, and (B) propylene glycol and / or glycerin as a wetting agent, a nonionic interface. At least one selected from (C) specific polyoxyethylene hydrogenated castor oil and polyoxyethylene alkyl ether as an activator, and (D) at least one water-soluble high selected from sodium carboxymethyl cellulose, carrageenan, and hydroxyethyl cellulose as a thickener. It contains molecular compounds and is free of ethanol.

  The blending amount of isopropylmethylphenol as the component (A) used in the present invention is 0.001 to 0.1% of the total composition in terms of satisfactorily exerting the sterilizing effect on periodontal pathogenic biofilms ( Mass%, the same shall apply hereinafter), particularly preferably 0.02 to 0.08%, and if it is less than 0.001%, there may be cases where sufficient sterilizing power cannot be exerted on the biofilm, 0.1% Exceeding this may cause the composition to become clouded with time at high temperatures and impair appearance stability.

  As the wetting agent of the component (B) used in the present invention, propylene glycol and glycerin may be blended alone or in combination with propylene glycol and glycerin. The total blending amount of component (B) (total blending amount of propylene glycol and glycerin) is preferably 3 to 20%, particularly 5 to 15% of the total composition in terms of solubilization of isopropylmethylphenol. If the blending amount is less than 3%, the composition may become cloudy over time when stored at low or high temperatures, and the appearance stability may be impaired. If the blending amount exceeds 20%, it may be applied to the mouth such as a mouthwash from the point of bitterness. It may not be suitable.

  As the nonionic surfactant of component (C) used in the present invention, polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100 moles, an alkyl chain length of 16 to 18 carbon chains And at least one selected from polyoxyethylene alkyl ethers having an average added mole number of ethylene oxide of 10 to 40 moles. Among these, polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 60 to 100 moles and carbon chain length of 16 in particular in terms of osmotic bactericidal power on periodontopathic biofilm and solubilization of isopropylmethylphenol. Polyoxyethylene alkyl ethers having an alkyl chain length of -18 and an average addition mole number of ethylene oxide of 20-40 mol are more preferably used. When the polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of less than 40 moles is used, it may be precipitated during low-temperature storage, and those exceeding 100 moles are generally not commercially available. When the polyoxyethylene alkyl ether having an average addition mole number of less than 10 moles is used, it may precipitate during low-temperature storage as described above, and those having a mole number exceeding 40 moles are generally not commercially available. Moreover, in the said polyoxyethylene alkyl ether, when the alkyl chain length is less than 16, a bitter taste and irritation | stimulation may be strong, and the thing exceeding 18 may be inferior in appearance stability in low temperature or high temperature.

  The blending amount of the component (C) is preferably 0.1 to 1.0% of the whole composition, more preferably 0.2 to 0.2% in terms of penetrating bactericidal power against periodontal pathogenic biofilm and solubilization of isopropylmethylphenol. 0.7%. If the blending amount is less than 0.1%, it is difficult to maintain the appearance stability at low temperature or high temperature, and if it exceeds 1.0%, the sterilizing power may be impaired.

  As the thickener of component (D) used in the present invention, at least one water-soluble polymer compound selected from sodium carboxymethyl cellulose, hydroxyethyl cellulose, and carrageenan is used. Although not particularly limited, carboxymethyl cellulose having a degree of etherification of 2.0 to 2.8, hydroxyethyl cellulose having a weight average molecular weight of 200,000 to 1.7 million, and carrageenan preferably using iota carrageenan, lambda carrageenan, etc. it can.

The degree of etherification is determined according to CMC Industrial Association analysis method (ashing method). 1 g of carboxymethyl cellulose is precisely weighed, put into a magnetic crucible and incinerated at 600 ° C., and sodium oxide produced by ashing is converted into N / 10. Titrate with phenolphthalein as an indicator with sulfuric acid, and calculate titration amount AmL per 1 g of carboxymethylcellulose into the following equation to indicate the obtained degree of etherification.
Degree of etherification = (162 × A) / (10,000-80 × A)

  The weight average molecular weight of hydroxyethyl cellulose is GPC system LS-8000 manufactured by Tosoh Corporation, 0.1M sodium chloride aqueous solution is used as the solvent, polyoxyethylene is used as the standard substance, and GPC analysis is performed at 30 ° C. Shows the calculated weight average molecular weight.

  The blending amount of the component (D) is preferably 0.05 to 1.0%, more preferably 0.3 to 0.7% of the entire composition in terms of appearance stability and usability of the composition. If it is less than 0.05%, it is difficult to maintain appearance stability at low temperature or high temperature, and if it exceeds 1.0%, it is not suitable for application to the mouth such as a mouthwash due to gelation of the composition, and the usability is low. It may be damaged, or the water-soluble polymer compound may precipitate over time during storage at a low temperature or high temperature, thereby impairing the appearance stability.

Furthermore, the liquid oral composition of the present invention preferably contains triclosan, and the combined use of triclosan can improve the bactericidal power against airborne bacteria, thereby allowing penetration into periodontal pathogenic biofilms. It has both a bactericidal effect and a bactericidal effect on airborne bacteria, and can exhibit more excellent oral disease prevention and improvement effects.
When triclosan is blended, the blending amount is preferably 0.001 to 0.1%, particularly 0.02 to 0.08% of the entire composition. If the blending amount is less than 0.001%, there may be a case where satisfactory bactericidal power cannot be exhibited against floating bacteria. It may damage.

  The liquid oral cavity composition of the present invention can be prepared and applied as a mouthwash, liquid dentifrice, etc., but the liquid oral cavity composition of the present invention, in addition to the above essential components, depending on its dosage form. Appropriate arbitrary components can be blended within a range not impeding the effects of the present invention. For example, wetting agents, thickeners, pH adjusters, preservatives, sweeteners, fragrances, surfactants, active ingredients, colorants and the like other than the above components can be contained.

  Examples of the wetting agent other than the component (B) include sorbitol, ethylene glycol, polyethylene glycol, xylit, malt, lactit, and the like, and the thickener other than the component (D) includes xanthan gum, sodium alginate, polyvinyl alcohol. Etc.

  Examples of pH adjusters include phthalic acid, phosphoric acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, carbonic acid and their potassium salts, sodium salts and ammonium salts, ribonucleic acid and salts thereof, and sodium hydroxide. 1 type, or 2 or more types selected from can be used, and it is particularly preferable to use a combination of phosphoric acid, citric acid and sodium salts thereof. In particular, the liquid oral composition of the present invention preferably adjusts the pH at 25 ° C. to 5.5 to 7.5, and sodium dihydrogen phosphate and sodium monohydrogen phosphate as pH adjusters in the vicinity thereof, Alternatively, it is preferable to use a combination of citric acid and sodium citrate.

Examples of the preservative may include sodium benzoate, methyl paraben, ethyl paraben, propyl paraben, butyl paraben, cetyl pyridinium hydrochloride, alkyldiaminoethyl glycine hydrochloride, potassium sorbate, and the like.
In addition, saccharin sodium, steviosite and the like can be contained as sweeteners.

  Perfume that does not contain ethanol is used, peppermint oil, spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil , Natural essential oils such as lavender oil and paracres oil, and l-carvone, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, spiranthol, etc. Perfume ingredients contained in the above natural essential oil, ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methyl phenyl glycidate, benzaldehyde, vanillin, Perfume ingredients such as tilvanillin, furaneol, maltol, ethyl maltol, gamma / delta decalactone, gamma / deltown decalactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, ethylene glycol 1-menthyl carbonate, etc. A combination of several perfume ingredients and natural essential oils (without ethanol), apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, yogurt 1 type, or 2 or more types of blended flavors such as these can be blended within a range that does not impede the effects of the present invention. The blending amount of the fragrance is preferably 0.00001 to 3% of the entire composition.

  As the surfactant other than the component (C), an anionic surfactant, an amphoteric surfactant and the like can be used. For example, anionic surfactants such as sodium myristyl sulfate, N-lauroyl sarcosinate, lauroyl methyl taurine, acyl amino acid salt, sodium dodecylbenzenesulfonate, α-sulfo fatty acid alkyl ester / sodium, alkyl phosphate ester salt, alkyl Betaine acetate-type amphoteric surfactants such as dimethylaminoacetic acid betaine, fatty acid amidopropyldimethylaminoacetic acid betaine, imidazoline-type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salt, N-fatty acid One kind of an amino acid type surfactant such as acyl-L-alginate salt can be used alone or in combination of two or more kinds within a range not impeding the effects of the present invention. The blending amount of the surfactant other than the component (C) is preferably 0.01 to 5% of the entire composition.

  Active ingredients other than isopropylmethylphenol and triclosan include anti-inflammatory agents such as tranexamic acid and epsilon-aminocaproic acid, enzymes such as dextranase, amylase, protease, mutanase, lysozyme, lytic enzyme, lytechenzyme, sodium fluoride , Fluorides such as sodium monofluorophosphate and stannous fluoride, vitamin C such as aluminum chlorohydroxy allantoin, allantoin, azulene, lysozyme chloride, ascorbic acid, dihydrocholesterol, glycyrrhetin salts, glycyrrhetinic acid, hydrocholesterol, chlorophyll , Copper chlorophyllin sodium, Thyme, Ogon, Clove, Hamamelis plant extract, Copper gluconate, Caropeptide, Sodium polyphosphate, Water-soluble Phosphoric acid compounds, polyethylene glycol, polyvinyl pyrrolidone, sodium lauroyl sarcosinate, anti-tartar agents, anti-plaque agents, potassium nitrate, may be added to aluminum lactate and the like. In addition, the compounding quantity of these active ingredients can be made into an effective quantity in the range which does not prevent the effect of this invention.

  As a colorant, a highly safe water-soluble dye such as Blue No. 1, Green No. 3, Yellow No. 4, Red No. 105 can be added.

  PET (polyethylene terephthalate), glass, polypropylene, and polyethylene can be used as the container for storing the liquid oral cavity composition of the present invention. However, the use of PET and glass is preferred in terms of suppressing adsorption of nonionic fungicides and fragrances. preferable.

EXAMPLES Hereinafter, although an experimental example, an Example, and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example.
For preparation of these liquid oral compositions, isopropylmethylphenol (manufactured by Osaka Kasei Co., Ltd.), triclosan (manufactured by Ciba Specialty Chemicals), polyoxyethylene (60) hydrogenated castor oil (manufactured by Nikko Chemicals) , Polyoxyethylene (80) hydrogenated castor oil (Nikko Chemicals), polyoxyethylene (30) cetyl ether (Nihon Emulsion), polyoxyethylene (20) cetyl ether (Nihon Emulsion), citric acid ( Fuso Chemical), sodium citrate (Fulka Chemical), xylitol (Rocket Fleure), glycerin (85%, Sakamoto Yakuhin Kogyo), propylene glycol (Asahi Glass Co.), carboxymethylcellulose sodium (Ernest) Gum, manufactured by Daicel Chemical Industries, degree of etherification 2 3), hydroxyethyl cellulose (HEC Daicel SE850, manufactured by Daicel Chemical Industries, Ltd., weight average molecular weight 1.48 million), carrageenan (CSI-1, San-Ei Gen FFI Co., Ltd. was used iota carrageenan). Furthermore, for the preparation of comparative examples, polyoxyethylene (30) hydrogenated castor oil (manufactured by Nikko Chemicals), polyoxyethylene (7) cetyl ether (manufactured by Nippon Emulsion Co., Ltd.), sodium alginate (Duck Algin, Kamogawa Kasei Kogyo Co., Ltd.) Manufactured), xanthan gum (monate gum DA, manufactured by Kelco), and ethanol (manufactured by Nippon Alcohol Sales Co., Ltd.). In the table, POE represents polyoxyethylene, and the percentages shown below mean mass% unless otherwise specified.

[Experimental Example 1]
Liquid oral compositions having the compositions shown in Tables 1 to 3 were prepared by a conventional method, and the penetration sterilization effect on the model biofilm was evaluated by the following method. The results are shown in Tables 1-3.

(1) Method for producing model periodontopathic biofilm 4 hours with human unstimulated saliva obtained by filtering a hydroxyapatite (HA) plate (manufactured by Asahi Optical Co., Ltd.) having a diameter of 7 mm and a thickness of 3.5 mm with a 0.45 μm filter. The treated solution is used as a model biofilm carrier, and the culture solution is 30 mg of trypticase soy broth (Difco) dissolved in 1 L of purified water, 5 mg of hemin (Sigma), menadione (Sigma) (Product) 0.5 mg added was used. In order to produce a model biofilm, Streptococcus gordonii ATC51656 strain and Actinomyces naesrandi ATCC51655 strain were used as oral resident bacteria, and Porphyromonas gingivalis ATCC33277 strain was used as a pathogenic bacterium. These three bacterial species were inoculated into the above-mentioned culture solution so as to be 2 × 10 ⁷ cfu / mL (cfu: colony forming units), respectively, at 37 ° C. under anaerobic conditions (5% carbon dioxide gas, 95% nitrogen) was continuously cultured for 2 weeks (the replacement rate of the culture medium was set to 10 Vol%) to form a model biofilm mixed with three bacterial species on the HA surface.

(2) Osmotic sterilization effect on model biofilm The formed model biofilm was immersed in 2 mL of the sample having the composition shown in Tables 1 to 3 for 3 minutes and washed 6 times with 1 mL of sterile physiological saline. Thereafter, the model biofilm was dispersed by sonication (200 μA, 10 seconds) with 4 mL of sterilized physiological saline, a 10% cotton defibrinated blood-containing trypticase soy agar plate (manufactured by Difco) and kanamycin sulfate (200 mg / L). (Manufactured by Sigma Co., Ltd.) containing 50 μL of trypticase soy blood agar plate and cultured under anaerobic conditions. The grown colonies were counted, and the number of remaining Porphyromonas gingivalis bacteria (cfu) was determined and determined according to the following criteria.

Osmotic sterilization effect criteria:
○: Viable count is less than 10 ⁷ Δ: Viable count is 10 ⁷ or more and less than 10 ⁸ ×: Viable count is 10 ⁸ or more

[Experimental example 2]
About the liquid oral cavity composition of the composition shown to Tables 1-3, the external appearance stability was evaluated by the following method. The results are shown in Tables 1-3.
(1) Appearance stability Samples of the composition shown in Tables 1 to 3 are filled in 450 mL PET containers of 450 mL, and the appearance stability after storage for 1 month in -5 ° C and 50 ° C constant temperature baths is as follows. In accordance with

Appearance stability evaluation criteria:
A: No change is observed compared to the initial product.
○: A slight amount of orientation is recognized.
Δ: Slight turbidity is observed.
X: Considerable cloudiness or precipitate is observed.

[Experimental Example 3]
About the composition for liquid oral cavity of the composition shown to Tables 1-3, the usability | use_condition was evaluated by the following method. The results are shown in Tables 1-3.
(1) Usability evaluation A sample containing 10 mL of the composition shown in Tables 1 to 3 was included in the mouth, rinsed for 30 seconds, then evaluated for the absence of irritation after mouthwash and bitterness in the following three stages, and an average of 10 people Points were calculated.

No irritation after mouthwash:
3: No irritation was observed.
2: Slight irritation was observed.
1: Stimulation was observed.

[Experimental Example 4]
About the composition for liquid oral cavity of the composition shown in Table 3, the bactericidal effect with respect to an airborne microbe was evaluated by the following method. The results are shown in Table 3.

(1) Bactericidal effect against floating bacteria The bacterial solution used was 30 mg of Trypticase Soy Broth (Difco) dissolved in 1 L of purified water as a culture solution, and Actinomyces naeslandi ATCC 51655 as oral resident bacteria. Using a strain, physiological saline was added so that the permeability at 550 nm of a solution cultured for one day at 37 ° C. under anaerobic conditions (5% carbon dioxide gas, 95% nitrogen) was 20. Add 0.3 mL of bacterial solution to 2.7 mL of the sample shown in Table 3, and after stirring, react at 37 ° C. for 1 minute. After stirring again, prepare five test tubes containing 2.7 mL of culture solution in advance. Then, 0.3 mL was added to the first test tube and stirred. 0.3 mL of this solution was collected, added to the second test tube, and stirred. This operation was similarly performed on the third to fifth test tubes in the same manner. After stirring the culture solution in the first, third, and fifth test tubes, 50 μL was smeared on a 10% cotton sheep defibrinated blood-containing trypticase soy agar plate (manufactured by Difco) and cultured under anaerobic conditions. The grown colonies were counted, and the number of remaining Actinomyces naeslandi bacteria (cfu) was determined and determined according to the following criteria.

Criteria for bactericidal effects against airborne bacteria:
○: Viable count is less than 10 ³ △: Viable count is 10 ³ or more and less than 10 ⁴ ×: Viable count is 10 ⁴ or more

  Next, liquid oral compositions of the following examples were prepared by conventional methods and evaluated in the same manner as described above, all having excellent sterilization power to pathogenic biofilms, appearance stability, and feeling of use. It was. In addition, the fragrance | flavor of the composition shown in following Table 4 was used for the fragrance | flavor.

[Example 17] Mouthwash A isopropylmethylphenol 0.05%
B Propylene glycol 4
Glycerin (85%) 2
C polyoxyethylene (60) hydrogenated castor oil 0.4
D Carrageenan 0.5
E Triclosan 0.05
Tranexamic acid 0.04
Dipotassium glycyrrhizinate 0.06
Citric acid 0.06
Sodium citrate 0.5
Methyl paraoxybenzoate 0.1
Saccharin sodium 0.01
Fragrance A 0.2
Water remaining
Total 100.0%

[Example 18] Mouthwash A isopropylmethylphenol 0.05%
B Propylene glycol 4
Glycerin (85%) 2
C polyoxyethylene (60) hydrogenated castor oil 0.3
D Hydroxyethylcellulose 0.5
E Triclosan 0.02
Xylitol 4
ε-aminocaproic acid 0.03
Sodium benzoate 0.3
Citric acid 0.03
Sodium citrate 0.25
Fragrance B 0.2
Water remaining
Total 100.0%

Example 19 Mouthwash A Isopropylmethylphenol 0.08%
B Propylene glycol 2
Glycerin (85%) 10
C Polyoxyethylene (100) hydrogenated castor oil 0.7
D Carboxymethylcellulose sodium 0.5
Xylitol 4
Acetic acid dl-α-tocophenol 0.05
Sodium fluoride 0.1
Citric acid 0.03
Sodium citrate 0.25
Fragrance C 0.3
Water remaining
Total 100.0%

Example 20 Mouthwash A Isopropylmethylphenol 0.1%
B Propylene glycol 5
Glycerin (85%) 5
C Polyoxyethylene (80) hydrogenated castor oil 0.7
D Hydroxyethylcellulose 0.5
Xylitol 4
Aspartame 0.02
Sodium pyrophosphate 0.17
Sodium polyphosphate 0.02
Citric acid 0.1
Sodium citrate 0.8
Fragrance D 0.4
Water remaining
Total 100.0%

Example 21 Mouthwash A Isopropylmethylphenol 0.06%
B Propylene glycol 5
C polyoxyethylene (20) cetyl ether 0.4
D Carrageenan 0.5
E Triclosan 0.04
Polyethylene glycol 600 5
Saccharin 0.01
Aspartame 0.02
Copper chlorofin sodium 0.01
Dextranase 0.02
Sodium ascorbate 0.03
Citric acid 0.06
Sodium citrate 0.5
Fragrance E 0.2
Water remaining
Total 100.0%

[Example 22] Mouthwash A isopropylmethylphenol 0.6%
B Propylene glycol 3
Glycerin (85%) 7
C polyoxyethylene (40) stearyl ether 0.5
D Carboxymethylcellulose sodium 0.3
Xylitol 2
Sorbitol (70%) 1
Lauroyl sarcosine sodium 0.2
Allantoin 0.01
Citric acid 0.03
Sodium citrate 0.5
Fragrance F 0.2
Water remaining
Total 100.0%

表中、部はいずれも質量部である（以下、同様。）。

In the table, all parts are parts by mass (the same applies hereinafter).

Claims (2)

(A) isopropylmethylphenol,
(B) propylene glycol and / or glycerin,
(C) From polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100 moles and a polyoxyethylene alkyl ether having a carbon chain length of 16 to 18 and an average addition mole number of ethylene oxide of 10 to 40 moles At least one nonionic surfactant selected,
(D) An ethanol-free liquid oral composition comprising at least one water-soluble polymer compound selected from sodium carboxymethylcellulose, carrageenan, and hydroxyethylcellulose. The ethanol-free liquid oral composition according to claim 1, further comprising (E) triclosan.