JPH04128217A - Composition for oral cavity - Google Patents

Abstract

PURPOSE:To provide a composition for oral cavity containing a copper compound and an amphoteric surfactant, not discolored even after stored for long period and having an excellent halitosis-preventing activity. CONSTITUTION:The composition for oral cavity contains 0.00001-2wt.% of a copper compound (e.g. copper gluconate) and 0.001-5wt.% of an amphoteric surfactant (e.g. lauryldimethylamino acetic acid betaine), preferably in a copper/ amphoteric surfactant weight ratio of 10/1 to 1/30. The components are suitably compounded with a conventional abrasive binder humectant surfactant sweetener, perfume, antiseptic, etc., and subsequently prepared into the objective composition. The composition can be prepared in the formulations of pastes, liquids, granules, solids, etc., in response to uses, e.g. dentifrices such as paste dentifrices, wet dentifrices or liquid dentifrices, mouth washes, troches, gargling tablets, chewing gums, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an oral composition such as a toothpaste that has a halitosis preventive effect by incorporating a copper compound. The present invention relates to an oral cavity composition that suppresses discoloration due to the combination of the following.

Traditionally, copper compounds such as copper gluconate and copper citrate are known to have antibacterial effects, bad breath removal effects, and plaque formation inhibiting effects. Various compositions have also been proposed (U.S. Pat. No. 3,044,939, U.S. Pat. No. 3,565,933, U.S. Pat. -169619, 56-169620, 81-143317,
62-142109, 62-164614).

However, according to studies conducted by the present inventors, oral compositions containing copper compounds sometimes undergo discoloration when stored for a long period of time. This discoloration is thought to be due to discoloration of copper itself and discoloration due to redox reactions of fragrances and the like that occur using copper as a catalyst, but in any case, it was desired to prevent discoloration due to the addition of such a copper compound.

In view of the above circumstances, the present inventors have conducted intensive studies on means for preventing discoloration of oral compositions due to the addition of copper compounds. The present inventors have discovered that when a surfactant is added, there is no discoloration even when stored at high temperatures for a long period of time, and the halitosis suppressing effect of the copper compound is effectively exerted, and the present invention has been completed.

In this case, the reason why discoloration is prevented by the combined use of a copper compound and an amphoteric surfactant is that the copper ions and the amphoteric surfactant form a stable coordination compound that suppresses copper free radicals. This is thought to be due to the fact that the discoloration of the oral composition due to the oxidation-reduction reaction of fragrances and the like that occurs using copper as a catalyst is suppressed.

Incidentally, various oral compositions containing amphoteric surfactants have been proposed (Japanese Patent Laid-open No. 118412/1983).
No. 58-67808, No. 58-194806, JP-A No. 1-213223) discloses that an amphoteric surfactant is added to an oral composition containing a copper compound, thereby suppressing discoloration caused by the copper compound. This is a new finding by the present inventors.

The present invention will be explained in more detail below.

As mentioned above, the oral composition according to the present invention is formed by using a copper compound and an amphoteric surfactant in combination.

Here, examples of copper compounds effective in suppressing bad breath include copper gluconate, copper citrate, copper sodium citrate, copper formate, cupric chloride, copper acetate, cupric chloride, and phosphorous rust-resistant. One of these can be used alone or in combination of two or more, and among these, copper gluconate is most suitable in terms of effectiveness and influence on the swelling properties of the binder. The amount of these copper compounds is usually 0.00001 of the total composition.
~2% (wt%, same hereinafter), especially 0.001~0.5
% is preferred. On the other hand, as the amphoteric surfactant, those of carboxylic acid type (aminoacetic acid type and betaine type), sulfuric acid ester type, sulfonic acid type, phosphoric acid ester type, etc. are used. Examples of the aminoacetic acid type include N-lauryl β-alanine, N-stearyl β-alanine, N-hydroxyethyl, N-dimethylaminopropionic acid, etc.
Examples of the betaine type include lauryldimethylaminoacetic acid betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, and the like. In addition, as sulfate ester types, N-lauryl N, N-lauryl N,
- Dimethylaminopropyl sulfate, etc., as sulfonic acid type, N-lauryl-N, N-dimethylaminopropylsulfonic acid, N-lauryl-N, N-di-n-propylaminopropylsulfonic acid, etc., as phosphate ester type teeth,
P-lauryl-P, P-dimethylphosphopropylsulfonic acid, etc. are used.

Among the above amphoteric surfactants, betaine type is particularly preferred, and among the betaine type, lauryldimethylaminoacetic acid betaine and 2-alkyl-N-carboxymethyl-
N-hydroxyethylimidazolinium betaine is preferred.

The above amphoteric surfactants may be used alone or in combination of two or more.

In addition, the amount of amphoteric surfactant blended is o, 0 of the entire composition.
In this case, the copper and amphoteric surfactant in the copper compound have a weight ratio of 10/1 to 1/300, more preferably 17%.
It is suitable to use in a ratio of 1 to 1150. If this weight ratio exceeds 10/1, the effect of suppressing discoloration in the oral composition may be poor, and if the weight ratio exceeds 1/3.
When it is less than 00, the deodorizing effect may not be sufficiently exhibited.

The oral composition according to the present invention can be used in various forms such as paste, liquid, powder, granule, etc., such as toothpaste, moisturized toothpaste, liquid toothpaste, mouthwash, troche, gargling tablet, chewing gum, etc. It can be prepared in a solid dosage form, and in this case, as other components of the oral composition, appropriate components commonly used depending on the purpose etc. can be blended.

For example, in the case of toothpaste, abrasives, binders, humectants, surfactants, sweeteners, fragrances, preservatives, various active ingredients, etc. may be blended.

Since the oral composition of the present invention is formulated in combination with a copper compound and an amphoteric surfactant, it does not discolor even when stored for a long period of time, and has an excellent effect on preventing bad breath.

Next, experimental examples will be shown to specifically explain the effects of the present invention.

[Experiment example]

A toothpaste with the composition shown in Table 1 was prepared by a conventional method, filled into a tube, and stored in a constant temperature bath adjusted to 50°C for one month. A comparative evaluation was made using the following evaluation criteria. The results are also listed in Table 1.

A slight discoloration is observed compared to the product stored at 5°C. A considerable discoloration is observed compared to the product stored at 5°C. From the results in Table 1, it is clear that copper compounds alone will cause discoloration during long-term storage. In addition to this, when an amphoteric surfactant is added to this, discoloration caused by copper compounds is effectively suppressed.

The present invention will be specifically explained below with reference to examples, but the present invention is not limited to the following examples.It should be noted that the toothpaste according to the following examples exhibits an excellent deodorizing effect and prevents bad breath. Very suitable as a toothpaste.

[Example 1] Toothpaste copper gluconate 0.05% aluminum hydroxide 40 titanium oxide
0.1 propylene glycol
3.0 Glycerin 20 Carrageenan 0° Sodium saccharin 0° Sodium lauryl sulfate Sodium benzoate Methyl paraoxybenzoate Flavor Sodium monofluorophosphate Purified water meter [Example 2] Toothpaste Copper gluconate N-stearyl β-alanine Polyethylene silicate anhydride Glycol 400 Sorbitol solution (60%) 100゜0゜0゜4.

0% 02% Sodium alginate saccharin sodium sodium lauryl sulfate Jetanolamide laurate Methyl paraoxybenzoate Butyl paraoxybenzoate de fragrance tranexamic acid ice making Total [Example 3] Toothpaste copper gluconate 1.0 0, 1 100, 0% 0.1 aluminum hydroxide Propylene glycol Sorbitol liquid (60%) glycerin Sodium polyacrylate saccharin sodium sodium lauryl sulfate sodium benzoate Methyl paraoxybenzoate fragrance β-Glycyrrhetinic acid purified water 2.0 1.5 0.2 1.5 0.3 0.1 1.0 0.1 Residue Total 100° 0% [Example 4] Toothpaste citric acid network 05% Silicic anhydride Aluminum oxide Propylene glycol glycerin xanthan gum Dipotassium glycyrrhizinate sodium lauryl sulfate 1.0 3,0 1, 5 0.2 1.0 sodium benzoate Butyl paraoxybenzoate fragrance Chlorhexidine gluconate solution purified water Total [Example 5] Toothpaste 0, 5 0.1 1.0 0.05 Residue 100° 0% copper gluconate Ol % imidazolinium betaine Calcium diphosphate titanium oxide Propylene glycol Sorbitol liquid (60%) glycerin o, 05 3,0 carrageenan saccharin sodium sodium lauryl sulfate sodium benzoate Methyl paraoxybenzoate fragrance dextranase water Total [Example 6] Toothpaste copper citrate 0.3 0, 2 1.5 0.3 0.2 1.0 500tJ/g 100.0% 0° % aluminum hydroxide polyethylene glycol 400 glycerin Sodium alginate saccharin sodium Sucrose laurate Methyl paraoxybenzoate fragrance sodium fluoride purified water Total [Example 7] Toothpaste copper citrate 100° 0% 07% N-lauryl-N,N-dimethy Ruaminopropylsulfonic acid Silicic anhydride Propylene glycol Sorbitol liquid (60%) carboxymethyl cellulose sodium saccharin sodium sodium lauryl sulfate Sucrose laurate ester sodium benzoate Methyl paraoxybenzoate fragrance dQ-a-tocopherol acetate purified water Total [Example 8] Toothpaste copper gluconate 0, 2 1, 5 0, 5 0.2 0.2 1, 0 0.1 Residue 100° 0% 0° 05% aluminum hydroxide titanium oxide Propylene glycol glycerin 0.1 2, 5 carrageenan 0, 3 saccharin sodium 0, 1 Dipotassium glycyrrhizinate sodium lauryl sulfate N-lauroyl sarcosine sodium sodium benzoate Butyl paraoxybenzoate fragrance glycine

Claims (1)

[Claims] 1. An oral composition comprising a copper compound and an amphoteric surfactant.