CN102365077A - Composition for oral cavity - Google Patents
Composition for oral cavity Download PDFInfo
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- CN102365077A CN102365077A CN2010800156842A CN201080015684A CN102365077A CN 102365077 A CN102365077 A CN 102365077A CN 2010800156842 A CN2010800156842 A CN 2010800156842A CN 201080015684 A CN201080015684 A CN 201080015684A CN 102365077 A CN102365077 A CN 102365077A
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- composition
- oral cavity
- copper
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- betaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
A composition for the oral cavity which comprises: (A) at least one kind of copper compound selected from copper gluconate, copper sulfate and hydrates of the same; (B) a betaine-type amphoteric surfactant; and (C) at least one kind of sugar alcohol selected from ethythritol, xylitol and mannitol. This composition for the oral cavity gives an actual feeling of improving periodontal disease by exerting a sufficient gum-tightening effect and, at the same time, exhibits effects of relieving an unpleasant bitterness characteristic to copper compounds and reducing irritation to the oral mucosa, thereby achieving an excellent feel in using.
Description
Technical field
The present invention relates to the good composition for oral cavity that contains copper compound of a kind of use feeling; It is for the dental bed that periodontal disease is improved the effectual sensation of effect; Have to give and tighten up the sense effect fully; And, brought into play for the peculiar not well bitterness of copper compound improve effect and to the inhibition effect of oral cavity mucosa irritation.
Background technology
In the past; The effect that has antibacterial effect, antihalitosis effect and prevent to form tartar because of copper compounds such as copper gluconate, copper citrate, copper sulfate; Various motions about the composition for oral cavity that cooperates copper compound are arranged, and about various copper compounds source, for improving effect and preventing the technological motion (with reference to patent documentation 1～5: japanese patent laid-open 2-212413 communique, japanese patent laid-open 8-310928 communique, No. 2882017 communique of Japan Patent, the flat 10-505831 communique of Japanese Patent Laid table, Japanese Patent Laid are opened the 2003-231621 communique) of variable color.
Generally, copper compound plays for the dental bed that periodontal disease is improved the effectual sense of effect and tightens up effect, as having tightening up acting composition, suitably is used in the medicine etc. of toothpaste and treatment periodontal disease.
But copper compound has not well tastes such as bitterness and metallic taste, in addition; Also can stimulate oral mucosa; But to just have in composition for oral cavity, fit into the copper compound of capacity in order to bring into play gratifying effect, thereby cause reducing the problem of use feeling.So far, proposed a lot of solutions, in patent documentation 6 (Japanese Patent Laid is opened the 2003-137755 communique), the applicant is proposed in the chemical compound that can discharge metal ions such as copper and improves metallic taste through cooperating menthol derivative to wait.
Yet; Through inventor's research, if improved not well tastes such as bitterness, because can damage the reduction of feeling effect and causing the actual effect sense of tightening up of being given simultaneously from copper compound; The technology of improving use feeling for former also leaves some room for improvement in this.On the other hand,, then suppress to give the effect of tightening up sense simultaneously if suppressed the stimulation that copper compound brings to oral mucosa, if do not lose that copper compound brings gratifyingly tighten up sense, only suppress the stimulation meeting of oral mucosa very difficulty.
So, for the inhibition effect of improving effect and oral mucosa being stimulated of the not well bitterness in copper compound source, tighten up the sense effect fully with giving for dental bed, have both the exploitation of the two technology simultaneously and extremely expect.The known technology document
Patent documentation
Patent documentation 1: japanese patent laid-open 2-212413 communique
Patent documentation 2: japanese patent laid-open 8-310928 communique
Patent documentation 3: No. 2882017 communique of Japan Patent
Patent documentation 4: the Japanese Patent Laid table is put down the 10-505831 communique
Patent documentation 5: Japanese Patent Laid is opened the 2003-231621 communique
Patent documentation 6: Japanese Patent Laid is opened the 2003-137755 communique
Patent documentation 7: Japanese Patent Laid is opened the 2000-297022 communique
Patent documentation 8: Japanese Patent Laid is opened the 2008-150335 communique
Patent documentation 9: Japanese Patent Laid is opened the 2007-320894 communique
Summary of the invention
The problem that invention will solve
The purpose of this invention is to provide the composition for oral cavity that a kind of use feeling well contains copper compound; It is for the dental bed that periodontal disease is improved the effectual sense of effect; Have to give and tighten up the sense effect fully; And, brought into play for the peculiar not well bitterness of copper compound improve effect and to the inhibition effect of oral cavity mucosa irritation.
Solve the means of problem
The inventor in order to achieve the above object; The result finds through concentrating on studies; Through in composition for oral cavity, cooperating the copper compound more than a kind, (B) betaine type amphoteric surfac-tant that (A) select from copper gluconate, copper sulfate and hydrate thereof and the sugar alcohol of (C) from erithritol, xylitol and mannitol, selecting more than a kind to use together; The inhibition effect of improving effect and oral mucosa being stimulated for the not well bitterness in copper compound source; Tighten up the sense effect fully with giving, can have both these effects for dental bed.
In containing the composition for oral cavity of copper compound, the bitterness in copper compound source, to the stimulation of oral mucosa, and tighten up sense, be with the oral cavity in the mucosa result that interacts and cause.Promptly; In the aforesaid composition for oral cavity that contains copper compound; For not well taste such as the bitterness that suppresses copper compound source with to the stimulation of oral mucosa, do not damage again simultaneously and give the effect of tightening up sense, consider the interaction of mucosa in copper compound and the oral cavity is changed.To this; The present invention is in copper gluconate, copper sulfate or its hydrate; With betaine type amphoteric surfac-tant and sugar alcohol acts, the interaction of mucosa and above-mentioned different in copper compound and the oral cavity is through these variations; Thereby infer the bitterness to improve the copper compound source, suppress stimulation, can also keep simultaneously and fully tighten up the sense effect what dental bed was given to oral mucosa.
Among the present invention such action effect from after obtained confirmation the embodiment that states.It constitutes any shortcoming of essential condition the present invention; For example replacing the betaine type amphoteric surfac-tant with amino acid type amphoteric surface active agent uses; Even sugar alcohol is arranged for another example; Replace above-mentioned (C) composition and use with Sorbitol or glycerol, these all miss one's aim, and have only to have satisfied the present invention all constitute essential conditions and just can achieve the goal.
Moreover well-known, as the gradation composition of composition for oral cavity, sugar alcohol is to be used as common wetting agent etc.Further, through cooperate sugar alcohol improved the variable color of the plant extract preparation that contains polyphenyl phenol technology (patent documentation 7: Japanese Patent Laid is opened the 2000-297022 communique), obtained to show that through in the compositions that contains fluorine compounds and sodium lauryl sulfate and trimethyl glycine, cooperating erithritol to improve the technology (patent documentation 8: Japanese Patent Laid is opened the 2008-150335 communique) of long-time storage stability, combination through double-glycine acid copper and xylitol the compositions (patent documentation 4) of improving the oral disease effect etc. is disclosed.In addition; As the technology that in composition for oral cavity, cooperates amphoteric surfactant; Through in containing the dentifrice composition of fluorine compounds, cooperating sodium lauryl sulfate and cation property copolymer and betaine type amphoteric surfac-tant, improved fluorine compounds and also be suggested in the technology (patent documentation 9: Japanese Patent Laid is opened the 2007-320894 communique) of intraoral anelasticity and use feeling etc. etc.Further, the applicant has proposed in containing the composition for oral cavity of copper compound as wetting agent, cooperates the technology (patent documentation 1) of the sugar alcohol of content of reducing sugar below 0.2 quality %, also has, and cooperates the technology (patent documentation 3) of amphoteric surfactant.These technology; Can prevent long-time variable color that causes because of copper compound and the effect that keeps antihalitosis; But different with problem to be solved by this invention, though any one all belongs to formation of the present invention, but do not show technological thought of the present invention and action effect.
Such as about the composition for oral cavity that contains copper compound various motions being arranged like this, and sugar alcohol and amphoteric surfactant are also known by the people as the gradation composition of composition for oral cavity.But; In the composition for oral cavity that contains copper gluconate, copper sulfate or its hydrate; Through cooperating betaine type amphoteric surfac-tant and combination as erithritol, xylitol or the mannitol of sugar alcohol; Do not damage copper compound source excellence give the effect of tightening up sense, improved the not well bitterness in copper compound source simultaneously satisfactorily and to the stimulation of oral mucosa, this is the inventor's new discovery.
Therefore, the present invention aims to provide a kind of composition for oral cavity, it is characterized in that,
The copper compound more than a kind that contains that (A) choose from copper gluconate, copper sulfate and hydrate thereof,
(B) betaine type amphoteric surfac-tant,
The sugar alcohol of (C) from erithritol, xylitol and mannitol, selecting more than a kind.
The effect of invention
The composition for oral cavity that contains copper compound of the present invention; For being given, the dental bed that improves the effectual sense of periodontal disease effect tightens up the sense effect fully; And brought into play to the distinctive not well bitterness of copper compound improve effect and to the inhibition effect of the stimulation of oral mucosa, use feeling is excellent.
The specific embodiment
Below, the present invention is carried out detailed explanation.Composition for oral cavity of the present invention is characterised in that and contains, the copper compound of (A) from copper gluconate, copper sulfate and hydrate thereof, choosing, (B) betaine type amphoteric surfac-tant and the sugar alcohol of (C) from erithritol, xylitol and mannitol, selecting more than a kind.
As the copper compound of (A) composition, use copper gluconate, copper sulfate, can a kind independent use also can 2 kinds and use.Copper gluconate and copper sulfate can be respectively acid anhydride or hydrate.As hydrate, can use as: copper sulfate 5 hydrates, 3 hydrates, 1 hydrate etc. contain the hydrate of water of crystallization.
The combined amount of copper compound, preferably copper accounts for 0.0026～0.51% overall (quality %, together following) of compositions, preferred especially 0.013～0.26%, especially preferred 0.026～0.26% in the chemical compound.If combined amount is less than 0.0026%, and giving the effect of tightening up sense and possibly being not in full use of copper compound source is difficult to give full play to the effect of improving bitterness if surpass 0.51%, also can improve use feeling unsatisfactorily sometimes.
As the betaine type amphoteric surfac-tant of (B) composition, can enumerate: lauryl betaine, stearyl betaine, lauryl dimethyl aminoacetic acid betanin, stearic dimethylamino acetic acid betanin, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, N-lauroyl-N '-carboxymethyl-N '-hydroxyethyl sodium ethylenediamine, dodecyl acid amido propyl betaine, coco-nut oil fatty acid amido propyl betaine, lauryl hydroxyl sulfo betaine etc.Wherein, preferably from lauryl dimethyl aminoacetic acid betanin, coco-nut oil fatty acid amido propyl betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, N-lauroyl-N '-carboxymethyl-N '-hydroxyethyl sodium ethylenediamine.These betaine type amphoteric surfac-tants can also can use more than 2 kinds in the lump in a kind of independent use.
The betaine type amphoteric surfac-tant can use commercially available article, and for example: Sanyo changes into 2-alkyl-N-carboxymethyl-N hydroxyethyl imidazolinium betaine (trade name LEBON 105) that industrial commercial firm makes, N-lauroyl-N '-carboxymethyl-N '-hydroxyethyl sodium ethylenediamine (trade name LEBON 101-H), coco-nut oil fatty acid amido propyl betaine liquid (trade name LEBON2000), lauryl dimethyl aminoacetic acid aqueous solutions of betaine (trade name NIKKOL AM-301) that day photochemistry commercial firm makes etc.As 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, but the 2-Oleum Cocois alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine sodium water solution of commodity in use エ Na ジ コ one Le C-40H by name, Lion Corporation's sale.
Betaine type amphoteric surfac-tant's combined amount, be preferably compositions overall 0.01～5%, preferred especially 0.05～2%, especially preferred 0.1～1%.If combined amount then can not be given full play to the inhibition effect that oral mucosa is stimulated sometimes less than 0.01%, if surpass 5% problem that oral mucosa can take place to stimulate because of surfactant, can not give full play to the effect of improving to bitterness in addition sometimes.
(C) composition is the sugar alcohol of from erithritol, xylitol and mannitol, selecting.These sugar alcohols can a kind use separately, also can 2 kinds or 3 kinds use in the lump.2 kinds when using in the lump, preferably use erithritol and xylitol in the lump.
(C) combined amount of composition sugar alcohol be compositions overall 2～50%, preferred especially 5～30%, especially preferred 10～30%.If combined amount then can not be given full play to the effect of improving to bitterness sometimes less than 2%, if surpass 50% can hinder that copper compound gives tighten up the sense effect, in addition, can not give full play to the inhibition effect that oral mucosa is stimulated sometimes.
Composition for oral cavity of the present invention can be mixed with toothpaste such as ordinary toothpaste, wet type toothpaste, liquid tooth paste; Collutory, gel, ointment, oral cavity freshener, gargle with tablet, oral cavity with various dosage forms such as ointment, chewing gum; Be particularly suitable for preparing toothpaste and gel, especially gel.If be mixed with such dosage form, reflect more effective effect than the present invention.In these preparations,,, in the scope of not damaging effect of the present invention, also can cooperate other composition, can prepare by conventional method according to the dosage form needs except above-mentioned necessary composition.
As other composition, for example during the situation of toothpaste, can cooperate various grinding agents, wetting agent, binding agent, surfactant, and can cooperate sweeting agent as required, spice, stain, antiseptic, pH regulator agent and other effective ingredient etc.During the situation of gel, can cooperate wetting agent, binding agent, surfactant and can cooperate sweeting agent, spice, stain, antiseptic, pH regulator agent, alcohol, oiliness composition and other effective ingredient etc. as required.
Can enumerate as grinding agent: precipitability silicon dioxide, silica gel, aluminosilicate, zeolite, zirconium silicate, calcium monohydrogenphosphate 2 hydrates and acid anhydride thereof, calcium pyrophosphate, calcium carbonate, aluminium hydroxide, aluminium oxide, magnesium carbonate, magnesium phosphate, insoluble Polymeric sodium metaphosphate., insoluble potassium metaphosphate, titanium oxide, hydroxyapatite, synthetic resin grinding agent etc. (combined amount: be generally compositions overall 5～50%).
As wetting agent, material except (C) composition sugar alcohol can be enumerated like polyhydric alcohol such as Sorbitol, glycerol, propylene glycol, Polyethylene Glycol, 1,3 butylene glycols.When cooperating wetting agent, its use level is generally 10～50%.
Can enumerate as binding agent: synthetic binders (combined amount is generally 0.5～10%) such as natural gum such as alginic acid derivant, guar gum, xanthan gum, arabic gum class, carrageenin, animal glue, polyvinyl alcohol, sodium polyacrylate, carboxyl ethylene polymer, polyvinylpyrrolidone such as cellulose derivatives such as sodium carboxymethyl cellulose, hydroxy ethyl cellulose, sodium alginate, propylene glycol alginate.
As surfactant, except that the betaine type amphoteric surfac-tant of (B) composition, can cooperate like nonionic surfactant, anionic surfactant and cationic surfactant.
As nonionic surfactant, ether type or fatty acid fat alkylolamides classes such as ester type surfactant, lauric acid diethyl amide such as polyol fatty acid ester, polyoxyethylene alkyl ether, poloxalkol, polyoxyethylene alkyl phenyl ether, polyoxyethylene hardened castor oils such as sugar alcohol fatty acid esters such as sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, fatty acid glyceride, polyglyceryl fatty acid ester, polyoxyethylene fatty acid glyceride, cithrol.
Can enumerate as the anionic surfactant: sodium lauryl sulfate; Alkyl sulfates such as sodium tetradecyl sulfate; N-lauroyl sarcosine sodium; N-acyl group sarcosine sodium such as N-myristoyl sarcosine sodium; Dodecylbenzene sodium sulfonate; Hydrogenated coconut glycerine monofatty ester sulfate mono sodium; Lauryl alcohol sulfoacetic acid sodium; N-acylaminoglutaricamiderivative hydrochlorates such as N-palmityl sodium glutamate; N-methyl-N-acyl group taurine sodium; N-methyl-N-acyl amino sodium propionate; Alpha-olefin sodium sulfonate etc.As cationic surfactant alkylammonium, alkylbenzene methyl ammonium salt etc. are arranged for example.
During as these surfactants of any components matching, its combined amount is generally 0.01～2%.
Moreover anionic surfactant's among the present invention, particularly sodium lauryl sulfate etc. alkyl sulfate because of the tendency that reduces use feeling is arranged, is preferably mismatched.When cooperating the situation of anion surfactant, its combined amount is preferred below 0.5%, and is preferred especially 0～0.1%, and 0% also can.Especially preferably mismatch.
Can enumerate as sweeting agent: saccharin sodium, stevioside, Stevia rebaudiana (Bertoni) Hemsl extract, p-met hoxycinnamic aldehyde, neohesperidin base oxidation chalcone derivative, perillartine etc.
Can enumerate as stain: blue No. 1 (FD&C Blue No.1 (42090)), yellow No. 4 (FD&C Yellow No.5 (19140)), titanium dioxide etc.Can enumerate as antiseptic: benzoic acid such as p-Hydroxybenzoate, sodium benzoate or its salt etc.Can enumerate as spice: terpenoid such as l-menthol, carvone, anethole, limonene and derivant thereof, Herba Menthae wet goods.
Can enumerate as the pH regulator agent: citric acid, fumaric acid, malic acid, tartaric acid, lactic acid etc.
Can enumerate as alcohol: the lower alcohol of carbon numbers such as ethanol below 3.When cooperating alcohol, its combined amount is generally 1～20%.
The oiliness composition can be enumerated: liquid paraffin; Liquid paraffin,light; Hard paraffin; Ceresine; Microwax; Squalene; Hydrocarbon ils such as squalene; Dodecyl acid; Myristic acid; Palmic acid; Stearic acid; Lauroleic acid; Oleic acid; Eicosatetraenoic acid; Linoleic acid; Linolenic acid; Fatty acids such as ricinoleic acid; Oleum lini; Siritch; Safflower oil; Oleum Glycines; Semen Maydis oil; Oleum Brassicae campestris; Oleum Gossypii semen; Olive oil; Camellia oil; Oleum Ricini; The cocoa resin; Petiolus Trachycarpi oil; Cortex cocois radicis wet goods vegetable oil; Adeps Bovis seu Bubali; Adeps Sus domestica; House oil; Animal wet goods such as Adeps caprae seu ovis.Wherein, considering preferred hydrocarbon ils, more preferably liquid paraffin, liquid paraffin,light aspect the intraoral anelasticity from preparation.When cooperating the oiliness composition, its combined amount is generally 0.1～10%.
Effective ingredient can be enumerated; Except that (A) composition copper compound, as: inorganic salts such as antibacterial, sodium chloride, polyphosphate sodium, Polymeric sodium metaphosphate., sodium phosphate, sodium tripolyphosphate, aluctyl., chitosans such as crude drug compositions such as the enzyme of vitamins, glucanase, change dextranase, lysozyme etc. such as ascorbic acid (vitamin C) salt vitamin E (tocopherol) ester, Cortex Phellodendri extract, Radix Scutellariae extract, Flos Caryophylli extract, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, dequalinium chloride, chlorhexidine hydrochloride, gluconic acid chlorhexidine, triclosan, isopropyl methyl phenol, order cypress alcohol or organic salt etc.In addition, these mixing active ingredients amounts are sneaked into effective dose in not hindering effective scope of the present invention.
Embodiment
Below, through embodiment and comparative example, more be described in detail the present invention, but the present invention is not limited by following embodiment.Combined amount in the following example all refers to quality %.In addition, be the composition of aqueous solution about form, any combined amount of all representing to be scaled pure material that shows in the table.
(embodiment, comparative example)
The composition for oral cavity (gel) that preparation is formed shown in table 1～4 is coated on the about 0.5g of composition for oral cavity on 5 members' of expert group the gingiva with finger.The inhibition effect of tightening up the sense effect, oral mucosa being stimulated of after just having applied dental bed having been given, to the improving effect, carry out subjective appreciation by 4 grades of scoring benchmark as follows respectively of bitterness, press commentary valency benchmark afterwards and assess.The result is shown in table 1～5.In addition, the details of gradation composition is as shown in table 6.
Give the effect of tightening up sense:
Scoring
4 minutes: feel to tighten up sense
3 minutes: arrive in a little and tighten up sense
2 minutes: almost imperceptiblely tighten up sense
1 minute: imperceptiblely tighten up sense
Give and tighten up sense Evaluation on effect benchmark:
◎: give the average mark more than 3.5 minutes below 4.0 minutes that tightens up the sense effect
Zero: give tighten up the sense effect average mark more than 3.0 minutes 3.5 minutes less than
△: give tighten up the sense effect average mark more than 2.0 minutes 3.0 minutes less than
*: give the average mark 2.0 minutes that tightens up the sense effect less than
Inhibition effect to the oral mucosa stimulation:
Scoring
4 minutes: complete imperceptible stimulation
3 minutes: almost imperceptible stimulation
2 minutes: feeling a little stimulated
1 minute: feeling stimulated
Oral mucosa is stimulated inhibition Evaluation on effect benchmark:
◎: the average mark that oral mucosa stimulate is suppressed effect is more than 3.5 minutes below 4.0 minutes
Zero: the average mark that oral mucosa stimulate is suppressed effect more than 3.0 minutes 3.5 minutes less than
△: the average mark that oral mucosa stimulate is suppressed effect more than 2.0 minutes 3.0 minutes less than
*: the average mark 2.0 minutes that oral mucosa stimulate is suppressed effect less than
The effect of improving to bitterness:
Scoring
4 minutes: complete imperceptible bitterness
3 minutes: almost imperceptible bitterness
2 minutes: feel bitterness a little
1 minute: feel bitterness, or stimulate strong
Bitterness is improved the Evaluation on effect benchmark:
◎: the average mark that bitterness is improved effect is more than 3.5 minutes below 4.0 minutes
Zero: the average mark that bitterness is improved effect more than 3.0 minutes 3.5 minutes less than
△: the average mark that bitterness is improved effect more than 2.0 minutes 3.0 minutes less than
*: the average mark 2.0 minutes that bitterness is improved effect less than
[table 1]
[table 2]
[table 3]
[table 4]
[table 5]
[table 6]
| Composition | The manufacturer | Trade name |
| Copper sulfate pentahydrate | Kanto Kagaku K. K. | Copper sulfate pentahydrate |
| Copper gluconate | With the pure medicine of light Co., Ltd. | Copper gluconate |
| 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine | Sanyo Chemical Industries, Ltd. | LEBON?105 |
| N-lauroyl-N '-carboxymethyl-N '-hydroxyethyl sodium ethylenediamine | Sanyo Chemical Industries, Ltd. | LEBON?101-H |
| Coco-nut oil fatty acid amido propyl betaine liquid | Sanyo Chemical Industries, Ltd. | LEBON?2000 |
| Lauryl dimethyl aminoacetic acid aqueous solutions of betaine | Nikko Chemicals Co., Ltd | NIKKOL?AM-301 |
| β-laurylamino-propionic acid sodium | Sanyo Chemical Industries, Ltd. | LEBON?APL |
| Erithritol | Mitsubishi-kagaku Foods Corp. | Erithritol |
| Xylitol | Mitsubishi Food Technology Co., Ltd | Xylitol |
| Mannitol | ROQUETTE commercial firm | PEARITOL (registered trade mark) 50C |
| Sorbitol | MERCK commercial firm | Parteck?SI?150 |
| Glycerol | Asahi Denka Kogyo K. K | Glycerol |
Claims (4)
1. a composition for oral cavity is characterized in that, contains
The copper compound of (A) from copper gluconate, copper sulfate and hydrate thereof, choosing more than a kind,
(B) betaine type amphoteric surfac-tant and
(C) sugar alcohol of from erithritol, xylitol and mannitol, selecting more than a kind.
As in the claim 1 record composition for oral cavity; Wherein, the betaine type amphoteric surfac-tant be selected from lauryl dimethyl aminoacetic acid betanin, coco-nut oil fatty acid amido propyl betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine and N-lauroyl-N '-carboxymethyl-N '-hydroxyethyl sodium ethylenediamine more than a kind or 2 kinds.
As in claim 1 or 2 record composition for oral cavity, wherein, contain (A) composition with copper be expressed as 0.013～0.26 quality %, (B) composition is that 0.05～2 quality %, (C) composition are 5～30 quality %.
4. like the composition for oral cavity of claim 1,2 or 3 records, be formulated into gel.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009-081716 | 2009-03-30 | ||
| JP2009081716 | 2009-03-30 | ||
| PCT/JP2010/054910 WO2010113688A1 (en) | 2009-03-30 | 2010-03-23 | Composition for oral cavity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102365077A true CN102365077A (en) | 2012-02-29 |
| CN102365077B CN102365077B (en) | 2013-10-16 |
Family
ID=42827983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080015684.2A Active CN102365077B (en) | 2009-03-30 | 2010-03-23 | Composition for oral cavity |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP5930713B2 (en) |
| KR (1) | KR101649003B1 (en) |
| CN (1) | CN102365077B (en) |
| HK (1) | HK1163509A1 (en) |
| WO (1) | WO2010113688A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112770765A (en) * | 2018-07-31 | 2021-05-07 | 姆柯萨科技有限公司 | Composition for preventing and/or treating urogenital mucosa |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102497986B1 (en) | 2014-12-12 | 2023-02-09 | 라이온 가부시키가이샤 | Composition for use in oral cavity |
| JP7347416B2 (en) | 2018-05-29 | 2023-09-20 | ライオン株式会社 | Oral composition |
| JP7075489B2 (en) * | 2018-07-17 | 2022-05-25 | 日本ゼトック株式会社 | Non-aqueous oral composition |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57171909A (en) * | 1981-04-15 | 1982-10-22 | Lion Corp | Composition for oral cavity |
| JPH02212413A (en) * | 1989-02-10 | 1990-08-23 | Lion Corp | Composition for oral cavity |
| JPH04128217A (en) * | 1990-09-19 | 1992-04-28 | Lion Corp | Composition for oral cavity |
| CN1158081A (en) * | 1994-09-15 | 1997-08-27 | 普罗克特和甘保尔公司 | Oral compositions |
| EP0920857A2 (en) * | 1997-11-06 | 1999-06-09 | Dentaid, S.A. | Oral composition for the treatment of halitosis |
| CN1960696A (en) * | 2004-03-29 | 2007-05-09 | 高露洁-棕榄公司 | Improved dental whitening method |
| CN1993104A (en) * | 2004-06-02 | 2007-07-04 | 高露洁-棕榄公司 | Anti-staining antibacterial dentifrice |
| JP2009007292A (en) * | 2007-06-28 | 2009-01-15 | Lion Corp | Oral composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08310928A (en) * | 1995-05-15 | 1996-11-26 | Lion Corp | Dentifrice composition |
| JP2000297022A (en) | 1999-04-12 | 2000-10-24 | Lion Corp | Composition for oral cavity |
| JP2003137755A (en) | 2001-11-02 | 2003-05-14 | Lion Corp | Composition for oral cavity |
| RU2275946C2 (en) * | 2001-11-28 | 2006-05-10 | Дзе Проктер Энд Гэмбл Компани | Composition for cleansing teeth (variants), binding system for monophase composition for cleansing teeth |
| JP2003231621A (en) | 2002-02-06 | 2003-08-19 | Lion Corp | Composition for oral cavity for preventing foul breath |
| JP2007008824A (en) * | 2005-06-28 | 2007-01-18 | Lion Corp | Composition for oral cavity |
| JP2007320894A (en) | 2006-05-31 | 2007-12-13 | Lion Corp | Toothpaste composition |
| JP4825122B2 (en) | 2006-12-19 | 2011-11-30 | ライオン株式会社 | Dentifrice composition |
-
2010
- 2010-03-23 JP JP2011507099A patent/JP5930713B2/en active Active
- 2010-03-23 KR KR1020117022572A patent/KR101649003B1/en active IP Right Grant
- 2010-03-23 WO PCT/JP2010/054910 patent/WO2010113688A1/en active Application Filing
- 2010-03-23 CN CN201080015684.2A patent/CN102365077B/en active Active
-
2012
- 2012-04-23 HK HK12104008.8A patent/HK1163509A1/en not_active IP Right Cessation
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| JPS57171909A (en) * | 1981-04-15 | 1982-10-22 | Lion Corp | Composition for oral cavity |
| JPH02212413A (en) * | 1989-02-10 | 1990-08-23 | Lion Corp | Composition for oral cavity |
| JPH04128217A (en) * | 1990-09-19 | 1992-04-28 | Lion Corp | Composition for oral cavity |
| CN1158081A (en) * | 1994-09-15 | 1997-08-27 | 普罗克特和甘保尔公司 | Oral compositions |
| EP0920857A2 (en) * | 1997-11-06 | 1999-06-09 | Dentaid, S.A. | Oral composition for the treatment of halitosis |
| CN1960696A (en) * | 2004-03-29 | 2007-05-09 | 高露洁-棕榄公司 | Improved dental whitening method |
| CN1993104A (en) * | 2004-06-02 | 2007-07-04 | 高露洁-棕榄公司 | Anti-staining antibacterial dentifrice |
| JP2009007292A (en) * | 2007-06-28 | 2009-01-15 | Lion Corp | Oral composition |
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| 裘炳毅: "《化妆品化学与工艺技术大全（下册）》", 31 May 1997, 中国轻工业出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112770765A (en) * | 2018-07-31 | 2021-05-07 | 姆柯萨科技有限公司 | Composition for preventing and/or treating urogenital mucosa |
| CN112770765B (en) * | 2018-07-31 | 2022-12-02 | 姆柯萨科技有限公司 | Composition for preventing and/or treating urogenital mucosa |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102365077B (en) | 2013-10-16 |
| KR20110133573A (en) | 2011-12-13 |
| JPWO2010113688A1 (en) | 2012-10-11 |
| KR101649003B1 (en) | 2016-08-17 |
| HK1163509A1 (en) | 2012-09-14 |
| WO2010113688A1 (en) | 2010-10-07 |
| JP5930713B2 (en) | 2016-06-08 |
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