JP2021031426A - Polyhydric alcohol dentifrice composition - Google Patents

Abstract

To provide a polyhydric alcohol dentifrice composition that gives a real feeling of warmth just after use in a mouth, and reduces a feeling of oil loss in the mouth and has a good feeling in use.SOLUTION: A polyhydric alcohol dentifrice composition contains (A) α-olefin sulfonate, and one or more selected from (B) a betaine type amphoteric surfactant and (C) a nonionic surfactant, with a moisture content of 2 mass% or less. The polyhydric alcohol dentifrice composition further contains a specific amount of (D) a cold sensing agent.SELECTED DRAWING: None

Description

The present invention relates to a polyhydric alcohol-based dentifrice composition that gives a gentle feeling of warmth immediately after use in the oral cavity and has a good feeling of use.

In oral compositions, especially dentifrice compositions, it is effective to increase the added value by giving an appropriate warmth as a feeling of use in the oral cavity from the viewpoint of improving the effect feeling by brushing teeth and further habituating it. Is. Various warming stimulants are used as means for giving a warming effect. For example, warming stimulants such as pepper and ginger may cause unpleasant irritation depending on the composition, and the amount used may be increased. When it was reduced, it became impossible to sufficiently give a feeling of warmth, and it was difficult to give a feeling of mild warmth with low stimulation satisfactorily.

As a dentifrice composition that gives a feeling of warmth, Patent Document 1 (Japanese Unexamined Patent Publication No. 2018-145163) describes an anionic surfactant selected from a water-soluble polyvalent metal salt, an alkyl sulfate, and an α-olefin sulfonate. When a betaine-type surfactant, glycerin and water are blended in a dentifrice composition containing the above, the astringency derived from the above metal is generated when the content of glycerin is 50% by mass or more and the mass ratio of glycerin / water is within a specific range. We propose that it is suppressed and gives a feeling of warmth (the feeling of warmth felt by the toothpaste during brushing), the foam is quickly dispersed, and there is no discomfort (dryness) in the oral cavity. A dentifrice composition containing 3.3% by mass or more of metal salt, sodium lauryl sulfate, glycerin, coconut oil fatty acid amide propyl betaine, and water is described as an example, but it still gives a feeling of warmth. There was room for improvement.

By the way, for oral care, not only a general water-based dentifrice composition containing water but also a non-water-based dentifrice composition containing no water as a liquid medium is used. There was a problem that the dispersibility in the oral cavity was poor and it was difficult to quickly develop the action effect and the feeling of effect.

Patent Documents 2 to 4 (Japanese Patent Laid-Open Nos. 2006-282550, 2006-182707, 2006-8530) include a specific polyhydric alcohol as a tooth whitening component in a non-aqueous dentifrice composition. It is proposed that when it is blended, applied to teeth with an application tool, and further brushed, it has an excellent tooth whitening effect and good dispersibility in the oral cavity. Patent Document 5 (Japanese Unexamined Patent Publication No. 2014-521707) is a non-aqueous dentifrice composition containing a specific surfactant system and having good mouthfeel, foam dispersion, etc., and Patent Documents 6 to 9 (Patent No. 3640967). Japanese Patent Application Laid-Open No. 2002-302249, Japanese Patent Application Laid-Open No. 2002-255772, International Publication No. 2018/069054) describes stability using a carboxyvinyl polymer or a specific polyvinylpyrrolidone in a non-aqueous oral composition. We propose improvement, taste improvement with baking soda, stability improvement with activator and alkali metal phosphate, etc. However, Patent Documents 2 to 9 do not mention the feeling of warmth.

JP-A-2018-145163 Japanese Unexamined Patent Publication No. 2006-282550 Japanese Unexamined Patent Publication No. 2006-182707 Japanese Unexamined Patent Publication No. 2006-8530 Japanese Unexamined Patent Publication No. 2014-521707 Japanese Patent No. 3640967 Japanese Unexamined Patent Publication No. 2002-302249 JP-A-2002-255772 International Publication No. 2018/069054

The present invention has been made in view of the above circumstances, and even if a warming stimulant is not used, a gentle feeling of warmth is given immediately after use in the oral cavity, and the feeling of degreasing in the oral cavity is reduced and the feeling of use is also improved. It is an object of the present invention to provide a good polyhydric alcohol-based dentifrice composition.

As a result of diligent studies to achieve the above object, the present inventors have added (A) α-olefin sulfonate to a polyhydric alcohol-based dentifrice composition having a water content of 2% by mass or less. When B) betaine-type amphoteric surfactant and (C) one or more selected from nonionic surfactants are used in combination, the feeling of warmth in the oral cavity rises quickly and is gentle from the start of use. It has been found that the feeling of warmth can be given, and the feeling of degreasing in the oral cavity after use can be reduced and improved to maintain a good feeling of use, and the present invention has been made.

More specifically, in a dentifrice composition in which the main component of the liquid medium is polyhydric alcohol, the lower the water content, the more heat of hydration is generated when it comes into contact with water when brushing teeth, and this heat of hydration causes the oral cavity It was thought that it gave a feeling of warmth, but on the other hand, as the amount of water decreased, the dispersibility and foaming in the oral cavity deteriorated, and it was not possible to give a feeling of effect quickly.
On the other hand, in the present invention, in a polyhydric alcohol-based dentifrice composition having a substantially non-aqueous composition having a water content of 2% by mass or less, the component (A) and the components (B) and / or (C) By combining with, the above-mentioned specific surfactant system was able to give a gentle warmth sensation (a sensation that the oral mucosa has a mild warmth different from the warmth stimulus) and to give a good feeling. In this case, in the non-aqueous composition as described above, if an anionic surfactant, particularly sodium lauryl sulfate, which is an alkyl sulfate, is added to improve dispersibility and foaming in the oral cavity, degreasing in the oral cavity is performed after use. The sensation (unpleasant sensation of degreasing oil on the tongue and oral mucosa) was exacerbated, causing the problem of being unsuitable for use. However, by using the component (A) as an anionic surfactant and combining the component (B) and / or the component (C) with the component (A), the feeling of degreasing in the oral mucosa is exacerbated as described above. It was possible to satisfactorily give a gentle feeling of warmth immediately after the start of use, while maintaining a good feeling of use.
Further, when the (D) cooling sensation agent was added, in addition to the above-mentioned mild feeling of warmth, it was possible to give a remarkable cooling sensation after use.
The action and effect of the present invention is peculiar to the above-mentioned specific surfactant system, and as shown in the comparative example described later, when the component (A) is lacking or the components (B) and (C) are lacking. However, the onset of warmth at the start of use or the lack of degreasing in the oral cavity after use was inferior, and this effect could not be obtained when an inappropriate surfactant was combined and blended. On the other hand, as shown in Examples described later, a polyhydric alcohol-based toothpaste containing the component (A) and the components (B) and / or (C) of the present invention and having a water content equal to or less than a specific value. The agent composition was excellent in both the absence of degreasing in the oral cavity after use and the rise of a feeling of warmth at the start of use.

Therefore, the present invention provides the following polyhydric alcohol-based dentifrice composition.
[1]
(A) α-olefin sulfonate and
A polyhydric alcohol containing one or more selected from (B) betaine-type amphoteric surfactant and (C) nonionic surfactant, and having a water content of 2% by mass or less. System dentifrice composition.
[2]
(B) The polyhydric alcohol-based dentifrice according to [1], wherein the betaine-type amphoteric tenside is selected from fatty acid amide propyl betaine, alkyl acetate betaine and alkyl imidazolinium betaine having an alkyl group having 10 to 16 carbon atoms. Composition.
[3]
(C) The nonionic surfactant is selected from polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, alkyl glucoside, fatty acid polyglyceryl and polyoxyethylene polyoxypropylene copolymer according to [1] or [2]. Polyhydric alcohol-based dentifrice composition.
[4]
The polyhydric alcohol-based dentifrice composition according to any one of [1] to [3], which contains 0.1 to 3% by mass of the component (A).
[5]
(B) The polyhydric alcohol-based dentifrice composition according to any one of [1] to [4], wherein when the betaine-type amphoteric surfactant is contained, the content thereof is 0.1 to 3% by mass.
[6]
(C) The polyhydric alcohol-based dentifrice composition according to any one of [1] to [5], wherein when a nonionic surfactant is contained, the content thereof is 0.05 to 2% by mass.
[7]
The polyhydric alcohol-based dentifrice composition according to any one of [1] to [6], which contains 13 to 95% by mass of polyhydric alcohol.
[8]
The polyhydric alcohol-based dentifrice composition according to any one of [1] to [7], which further contains (D) a cooling sensation agent in an amount of 0.0001 to 0.3% by mass.

According to the present invention, it is possible to provide a polyhydric alcohol-based dentifrice composition that gives a gentle feeling of warmth in the oral cavity immediately after use, reduces the feeling of degreasing in the oral cavity, and has a good taste. The polyhydric alcohol-based dentifrice composition of the present invention does not require the addition of irritating warming components such as pepper and ginger, which are relatively irritating as warming agents, and provides a mild warming sensation with low irritation. It can be imparted, and by further adding (D) a cooling sensation agent, a gentle feeling of warmth rises at the start of use, and it is also possible to impart a unique feeling of use in which the feeling of cooling gradually becomes conspicuous. Is.

Hereinafter, the present invention will be described in more detail. The polyhydric alcohol-based dentifrice composition of the present invention comprises one or more selected from (A) α-olefin sulfonate, (B) betaine-type amphoteric surfactant and (C) nonionic surfactant. And the water content is 2% by mass or less.
Further, in the present invention, the "defatting sensation" is an unpleasant sensation that the oil on the tongue and the oral mucosa has been deprived, and the "warm sensation" is a sensation that the oral mucosa is warm.

In the present invention, the "polyhydric alcohol-based dentifrice composition" is a dentifrice composition containing a polyhydric alcohol as a main component of a liquid medium serving as a base. The dentifrice composition in which the main component of a general liquid medium is water is "water-based".
As the polyhydric alcohol, a polyhydric alcohol that is liquid at 25 ° C., which generates heat of hydration when in contact with water, can be used. Specific examples thereof include glycerin, polyethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, polypropylene glycol and the like having an average molecular weight of 190 to 630 (average molecular weight described in the Pharmaceutical Non-medicinal Product Raw Material Standard 2006, the same applies hereinafter). Among these, glycerin, polyethylene glycol having an average molecular weight of 190 to 630, and butylene glycol are preferable from the viewpoint of raising a feeling of warmth and improving the feeling of degreasing in the oral cavity.
As the polyethylene glycol having the specific average molecular weight, for example, polyethylene glycol 200 (average molecular weight 190 to 210), polyethylene glycol 400 (average molecular weight 380 to 420), and polyethylene glycol 600 (average molecular weight 570 to 630) can be used. it can.
Polyhydric alcohols have their own bitterness, but glycerin is a polyhydric alcohol with relatively little bitterness. Therefore, from the viewpoint of reducing bitterness derived from the liquid medium, it contains at least glycerin, and the content of glycerin is 20 to 100% (mass%, the same applies hereinafter), particularly 50 to 85%, and further 50 to 80% of the total polyhydric alcohol. Is more preferable.
In addition, among polyhydric alcohols, polyethylene glycol having the specific average molecular weight contributes relatively strongly to the feeling of warmth. Therefore, from the viewpoint of the strength of the feeling of warmth, it is preferable to contain at least the polyethylene glycol, and the content of the polyethylene glycol is more preferably 10% or more, particularly 15 to 30% of the whole composition. If it exceeds 30%, the bitterness derived from polyethylene glycol may affect the usability, but if it is 30% or less, a good usability can be maintained.
In the present invention, the polyhydric alcohol is a combination system of glycerin and polyethylene glycol and / butylene glycol having an average molecular weight of 190 to 630, particularly a combination system of glycerin and polyethylene glycol having an average molecular weight of 190 to 630, and further, of glycerin. When the content is 50% or more, particularly 50 to 85% of the total polyhydric alcohol, it is particularly preferable from the viewpoint of exerting the effect of the present invention.

The larger the amount of the polyhydric alcohol, the higher the feeling of warmth, but from the viewpoint of the rise of the feeling of warmth and the improvement of the feeling of degreasing in the oral cavity, 13 to 95% of the whole composition is preferable, and more preferably 20 to 90. %, Especially preferably 25 to 85%, still more preferably 30 to 80%, and may be 50% or more.

Further, the polyhydric alcohol-based dentifrice composition of the present invention has a water content of 2% or less, may be less than 2%, and is preferably 1% or less, particularly 0.5% or less. The lower the water content, the more preferable, and water may not be added and the addition amount may be 0%. This polyhydric alcohol-based dentifrice composition preferably has a non-water composition that does not contain water, but even if water is not added to the composition, for example, water is contained in the raw materials of other compounding components. If so, this water is brought in, and water may be brought in due to pH adjustment or moisture absorption of raw materials, etc. Therefore, in consideration of these waters, the allowable upper limit of water is specified as described above. is there. Therefore, the "substantially non-aqueous composition" described here means that the amount of water in the composition is equal to or less than the above value.
In the present invention, by using a substantially non-water (including a low water content) base mainly composed of a polyhydric alcohol as described above, this substantially non-water composition dentifrice composition can be obtained in the oral cavity. Heat of hydration is generated by contact with water during use, and a gentle warmth can be given to the oral cavity, and even if a stimulating warmth component such as toothpaste is not blended, the above-mentioned warmth feeling is felt. Can be given.

(A) The α-olefin sulfonate has an effect of improving the rise of the feeling of warmth.
As the α-olefin sulfonic acid salt, an alkali metal salt such as sodium or potassium of α-olefin sulfonic acid having 14 to 16 carbon atoms can be used, and an α-olefin sulfonic acid salt having 14 carbon atoms is particularly preferable. It is a sodium salt (generic name; sodium tetradecene sulfonate). For these, commercially available products that can be used for oral preparations can be obtained, and for example, the trade name "K Liporan PJ-400CJ" manufactured by Lion Specialty Chemicals Co., Ltd. can be used.

The blending amount of the α-olefin sulfonate (A) is preferably 0.1 to 3%, more preferably 0.5 to 2% of the total composition. When the blending amount is 0.1% or more, the dispersibility of the preparation in the oral cavity at the time of use is improved, and a sufficient rise of a feeling of warmth can be obtained. When it is 3% or less, the feeling of degreasing in the oral cavity after use is sufficiently reduced.

In addition, (B) betaine-type amphoteric surfactant and (C) nonionic surfactant each have an effect of reducing and improving the feeling of degreasing in the oral cavity due to the component (A), and in particular, the component (B) , (A) also has the effect of accelerating the rise of the feeling of warmth.
In the present invention, any one of the components (B) and (C) may be blended, but when the components (B) and (C) are blended in particular, the feeling of degreasing in the oral cavity is improved and the feeling of warmth is felt. It is more preferable from the viewpoint of rising.

The betaine-type amphoteric surfactant preferably has an alkyl group having 10 to 16 carbon atoms, and is preferably a fatty acid amide propyl betaine having the alkyl group, an alkyl acetate betaine having the alkyl group, and an alkyl having the alkyl group. Imidazolinium betaine can be used.
Specifically, the fatty acid amide propyl betaine includes coconut oil fatty acid amide propyl betaine and the like, the alkyl acetate betaine includes lauryl dimethylamino acetate betaine and the like, and the alkyl imidazolinium betaine includes alkylcarboxymethyl hydroxyethyl imidazolinium betaine and the like. Can be mentioned. Among these, fatty acid amide propyl betaine and alkyl acetate betaine, particularly fatty acid amide propyl betaine coconut oil fatty acid amide propyl betaine are preferable. In the present invention, since the water content in the dentifrice composition is defined as 2% or less, it is preferable to use a solution or powder having a pure content (betaine pure content) of 65% or more as the betaine-type surfactant. ..
These can be used alone or in combination of two or more. Moreover, a commercially available product can be used.

Examples of the (C) nonionic surfactant include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, alkyl glucoside, fatty acid polyglyceryl, and polyoxyethylene polyoxypropylene (EOPO) copolymer. Further, the polyoxyethylene hydrogenated castor oil preferably has an average addition mole number of ethylene oxide of 5 to 100, particularly 5 to 60. The polyoxyethylene alkyl ether preferably has an average number of moles of ethylene oxide added of 5 to 30, and an alkyl group having 12 to 18 carbon atoms. Specifically, the above E.I. O. Examples thereof include polyoxyethylene lauryl ether and polyoxyethylene stearyl ether. The polyoxyethylene polyoxypropylene (EOPO) copolymer preferably has an average addition mole number of ethylene oxide of 20 to 210 and an average addition mole number of propylene oxide of 15 to 60, and may be a block copolymer or a random copolymer.
Among these, polyoxyethylene hydrogenated castor oil and polyoxyethylene alkyl ether are preferable, and polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 5 to 60 is particularly preferable.
These may be used alone or in combination of two or more. Moreover, a commercially available product can be used.

When the component (B) is blended, the blending amount thereof is preferably 0.1 to 3%, more preferably 0.3 to 2% of the entire composition. When the blending amount is 0.1% or more, the degreasing feeling in the oral cavity is sufficiently improved, and the rise of the feeling of warmth is improved. When it is 3% or less, the bitterness due to itself is suppressed and a good feeling of use can be sufficiently maintained.

When the component (C) is blended, the blending amount thereof is preferably 0.05 to 2%, more preferably 0.5 to 1% of the total composition. When the blending amount is 0.05% or more, the feeling of degreasing in the oral cavity is sufficiently improved. When it is 2% or less, the bitterness due to itself is suppressed and a good feeling of use can be sufficiently maintained.

In the present invention, in addition to the component (A) and the components (B) and / or (C), surfactants other than these may be blended within a range that does not interfere with the effects of the present invention.
Examples of the optional surfactant include anionic surfactants other than the component (A), for example, an acyl amino acid salt, an acyl taurine or a salt thereof, and an alkyl sulfate such as sodium lauryl sulfate. The blending amount of these arbitrary anionic surfactants is preferably 0 to 0.3% of the total composition from the viewpoint of the onset of warmth and the absence of degreasing in the oral cavity.

In the present invention, when (D) a cooling sensation agent is further added, it is possible to impart a moderately strong and outstanding cooling sensation to the oral cavity after use. In this case, by blending the component (A) and the component (B) and / or the component (C) and the component (D), a gentle warm sensation rises at the start of use and is sufficiently felt, and this warm sensation is felt. However, as time goes by, it gradually changes to a cool feeling, and after use, the cool feeling stands out, which can give a unique feeling of use that changes the sensation.

The cold sensitizer is, for example, N-ethyl-p-mentane-3-carboxamide, menthyl lactate, menthyl monosuccinate, isopulegol, menthone glycerol ketal, N- (4-cyanomethylphenyl) -p-menthan carboxamide. , 3-l-mentoxypropane-1,2-diol and the like. Among them, N-ethyl-p-menthane-3-carboxamide and N- (4-cyanomethylphenyl) -p-menthane carboxamide are cool. It is preferable from the viewpoint of giving a feeling.
These may be used alone or in combination of two or more. Moreover, a commercially available product can be used.

The blending amount of the component (D) is preferably 0.0001 to 0.3%, more preferably 0.001 to 0.2%, still more preferably 0.01 to 0.1% of the entire composition. Within this range, a feeling of coolness can be sufficiently obtained, and irritation and bitterness due to itself can be sufficiently suppressed, and a feeling of use can be sufficiently maintained.

The polyhydric alcohol-based dentifrice composition of the present invention can be in the form of a paste, gel, or the like, and can be particularly prepared as a dentifrice. Further, in addition to the above components, other known components according to the dosage form and the like can be blended as needed, and these can be used within a range that does not interfere with the effects of the present invention. For example, abrasives, binders, oily ingredients, flavors, sweeteners, preservatives, colorants, active ingredients and the like can be mentioned.

Examples of the abrasive include silica-based abrasives such as precipitated silica, silica gel, aluminosilicate and zirconosilicate, calcium carbonate, calcium phosphate, aluminum silicate and aluminum hydroxide. The blending amount of the abrasive is usually 0 to 70%, particularly 2 to 30% of the total composition.

As the binder, an organic binder such as a water-soluble polymer or an inorganic binder can be used.
Examples of the organic binder include cellulose derivatives such as sodium carboxymethyl cellulose, gums such as xanthan gum, tragant gum, karaya gum and arabiya gum, carboxyvinyl polymers, polyvinyl alcohol, crosslinked sodium polyacrylate, carrageenan, sodium alginate and polyvinylpyrrolidone. Be done. Examples of the inorganic binder include thickening silica such as precipitated silica, igneable silica, gelling silica and gelling aluminum silica, and clay minerals such as bee gum, laponite and bentonite. The blending amount of the binder is usually 0.1 to 10% of the whole composition, particularly 0.2 to 5%.
The binder is preferably an organic binder, particularly a carboxyvinyl polymer, and the blending amount thereof is preferably 0.1 to 3%, particularly 0.3 to 2% of the entire composition.

Oily components include hydrocarbons (squalane, liquid paraffin, vaseline, microcrystallin wax, etc.), higher alcohols with 8 to 22 carbon atoms (lauric alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, isostearyl alcohol, etc.), carbon. Examples of the number 8 to 22 are higher fatty acids (lauric acid, myristic acid, oleic acid, isostearic acid, etc.), vegetable oils (olive oil, castor oil, palm oil, etc.), fatty acid esters (isopropyl myristate, etc.).

Fragrances are peppermint oil, sparemint oil, anis oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamon oil, coriander oil, mandarin oil, lime. Oil, lavender oil, rosemary oil, laurel oil, camomill oil, caraway oil, majorum oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute peppermint , Absolute rose, orange flower, and other natural fragrances, and processed fragrances (pre-reservoir cut, rear-reservoir cut, distilling, liquid extraction, essence, powder fragrance, etc.), and menthol. , Carvone, Anetol, Cineol, Methyl salicylate, Synamic aldehyde, Eugenol, 3-l-mentoxypropane-1.2-diol, Timor, Linarol, Linaryl acetate, Limonen, Menton, Menthyl acetate, N-substituted-Peppermint -3-Carboxamide, Peppermint, Octylaldehyde, Citral, Pregon, Calvier Acetate, Anisaldehyde, Ethylacetate, Ethylbutyrate, Allylcyclohexanepropionate, Methylanthranilate, Ethylmethylphenylglycidate, Vanillin, Undecalactone , Hexanal, propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethylsulfide, cycloten, furfural, trimethylpyrazine, ethyllactate, methyllactate, ethylthioacetate and other single flavors, as well as strawberry flavor, apple flavor, banana flavor, pineapple flavor. , Grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor and other blended flavors, and known flavor materials used in dentifrice compositions can be used.
The above fragrance material is preferably used in an amount of 0.000001 to 1% in the composition, and the fragrance for perfume using the above fragrance material is preferably used in an amount of 0.1 to 2.0% in the composition. Good.

Examples of the sweetener include sodium saccharin, stebioside, stevia extract, neohesperidyl dihydrochalcone, glycyrrhizin, perillartine, p-methoxycinnamic aldehyde, aspartame, xylitol and the like.
Examples of the preservative include paraoxybenzoic acid esters such as butylparaben, propylparaben and ethylparaben, and sodium benzoate.
Examples of the colorant include blue No. 1, blue No. 4, green No. 3 and the like.

The active ingredients are fluorine-containing compounds such as sodium monofluorophosphate and sodium fluoride; water-soluble phosphoric acid compounds such as potassium salt and sodium salt of orthophosphate; allantin such as allantin and allantinchlorohydroxyaluminum or derivatives thereof; Enzymes such as stranase, mutanase, protease; copper compounds such as copper gluconate; chelating phosphate compounds such as glycerophosphate; cationic bactericides such as cetylpyridium chloride, benzethonium chloride, benzalkonium chloride; isopropylmethylphenol Non-ionic bactericides such as; Touki soft extract; Extracts such as Oubaku extract, chamomile, chowji, rosemary, Ogon, Benibana, tranexamic acid, hinokithiol, sodium chloride, dl-α-tocopherol acetate, coenzyme Q10, dihydro Cholesterol, α-bisabolol, chlorhexidine salts, triclosan, sanginaline extract, azulene, glycyrrhizin, glycyrrhetinic acid, sodium copper chlorophyllin, chlorophyll, strontium chloride, velverin, hydroxamic acid and its derivatives, pyrophosphate, tripolyphosphate, zeolite, methoxy Examples include ethylene anhydride maleic acid copolymer, epidihydrocholesterin, trichlorocarbanilide, and zinc citrate. These can be blended in an effective amount within a range that does not interfere with the effects of the present invention.

Hereinafter, the present invention will be specifically described with reference to Examples, Comparative Examples, and Formulation Examples, but the present invention is not limited to the following Examples. In the following examples,% indicates mass% unless otherwise specified.

[Examples, comparative examples]
Polyhydric alcohol-based dentifrice compositions (dentifrices) having the compositions shown in Tables 1 to 5 were prepared by a conventional method, and the evaluations shown in each table were performed by the following methods. The results are also shown in the table. In the table, the numerical value indicating the blending amount of each component is the net amount.
The dentifrice compositions shown in Tables 1 to 5 are substantially non-aqueous compositions having a water content of 2% or less.

<Evaluation method>
(1) Evaluation method for the lack of degreasing in the oral cavity after use Ten testers placed 1 g of the dentifrice composition on a toothbrush, brushed it for 3 minutes in the usual way, and rinsed it with water in the oral cavity. The lack of degreasing feeling was judged on a 5-point scale according to the scoring criteria shown below.
The average score of 10 testers was calculated, evaluated according to the evaluation criteria shown below, and shown in the table with ☆, ◎, ○, Δ, and ×.
Here, the "solvent degreasing sensation" is an unpleasant sensation that the oil on the tongue and oral mucosa has been deprived.
Rating criteria 5 points: No feeling of degreasing in the oral cavity 4 points: Almost no feeling of degreasing in the oral cavity 3 points: Slightly feeling of degreasing in the oral cavity, but not noticeable 2 points: Oral Feeling degreasing inside 1 point: Feeling degreasing in the oral cavity strongly Evaluation criteria ☆: Average 4.5 points or more and 5.0 points or less ◎: Average 4.0 points or more and less than 4.5 points ○: Average 3. 0 points or more and less than 4.0 points Δ: Average 2.0 points or more and less than 3.0 points ×: Average 1.0 points or more and less than 2.0 points

(2) Evaluation method for the rise of warmth at the start of use Ten testers placed 1 g of the dentifrice composition on a toothbrush and started brushing with the usual method to evaluate the rise of warmth in the oral cavity. , Judgment was made in 5 stages according to the scoring criteria shown below.
The average score of 10 testers was calculated, evaluated according to the evaluation criteria shown below, and shown in the table with ⊚, ◯, Δ, and ×.
Here, the "feeling of warmth" is the feeling that the oral mucosa has a gentle warmth different from the stimulus of warmth, and the "rise of feeling of warmth" is the above-mentioned temperature after the start of brushing. It means the speed at which you can feel the feeling.
Rating criteria 5 points: Very fast rise of warmth sensation 4 points: Fast rise of warmth sensation 3 points: Slightly fast rise of warmth sensation 2 points: Slow rise of warmth sensation 1 point: Warm sensation Evaluation criteria for a very slow start of actual feeling ◎: Average 4.0 points or more and 5.0 points or less ○: Average 3.0 points or more and less than 4.0 points △: Average 2.5 points or more and less than 3.0 points ×: Average 1.0 points or more and less than 2.5 points

(3) Evaluation method of no bitterness during use 10 testers put 1 g of the dentifrice composition on a toothbrush and brushed it by a normal method, and the bitterness felt in the oral cavity (betaine-type amphoteric surfactant, which is a compounding ingredient). The activator, the nonionic surfactant, and the unique bitterness derived from the cooling sensitizer) were judged on a 5-point scale according to the scoring criteria shown below.
The average score of 10 testers was calculated, evaluated according to the evaluation criteria shown below, and shown in the table with ⊚, ◯, Δ, and ×.
Rating criteria 5 points: No bitterness 4 points: Almost no bitterness 3 points: Slightly bitter but not noticeable 2 points: Bitterness 1 point: Strong bitterness Evaluation criteria ◎: Average score 4.0 points or more and 5.0 points or less ○: Average points 3.0 points or more and less than 4.0 points Δ: Average points 2.0 points or more and less than 3.0 points ×: Average points 1.0 points or more and 2.0 points Less than a point

(4) Evaluation method of the cool feeling in the oral cavity after use Ten testers put 1 g of the dentifrice composition on a toothbrush, brushed it for 3 minutes by the usual method, rinsed it with water, and then cooled the oral cavity. The feeling was compared with the control dentifrice composition and judged on a 5-point scale according to the scoring criteria shown below. The control dentifrice composition is a water-based dentifrice composition (dentifrice) having the same composition except that water is added instead of the concentrated glycerin of each composition.
The average score of 10 testers was calculated, evaluated according to the evaluation criteria shown below, and shown in the table with ⊚, ◯, Δ, and ×.
Here, the "cool feeling" indicates an appropriate cool feeling that is felt after rinsing the mouth.
Rating criteria 5 points: Very strong feeling of coolness 4 points: Strong feeling of coolness 3 points: Slightly strong feeling of coolness 2 points: Equivalent feeling of coolness 1 point: Weak feeling of coolness Evaluation criteria ◎: Average 4.0 points 5.0 points or less ○: Average 2.5 points or more and less than 4.0 points Δ: Average 2.0 points or more and less than 2.5 points ×: Average 1.0 points or more and less than 2.0 points

The following were used as the component (A), the component (B), the component (C), and the component (D).
(A) component;
Sodium tetradecene sulfonate (manufactured by Lion Specialty Chemicals Co., Ltd., trade name: K lipolan PJ-400CJ)
(B) component;
Coconut oil fatty acid amide propyl betaine (manufactured by Evonik, trade name: TEGO BETAIN CK D, composition in the product (coconut oil fatty acid amide propyl betaine: sodium chloride: water = 85: 14.5: 0.5, pure betaine 85%) )))
Betaine lauryldimethylaminoacetate (manufactured by Sigma-Aldrich, trade name: (Lauryldimethylamino) acetate, pure betaine ≥ 95%)
Ingredient (C);
Polyoxyethylene (20) hardened castor oil (manufactured by Nippon Surfant Industry Co., Ltd., trade name: NIKKOL HCO-20)
Polyoxyethylene (5) Stearyl ether (manufactured by Aoki Yushi Kogyo Co., Ltd .: trade name: Blaunon SR-705)
Ingredient (D);
N-Ethyl-p-Menthane-3-carboxamide (manufactured by Givaudan, trade name: WS-3)
N- (4-Cyanomethylphenyl) -p-menthanecarboxamide (manufactured by Givaudan, trade name: Evercool (registered trademark) G-180)
Further, as the carboxyvinyl polymer, a trade name: Carbopol (registered trademark) 980 manufactured by Lubrizol was used.
In polyoxyethylene hydrogenated castor oil and polyoxyethylene stearyl ether, the values in parentheses are the average number of moles of ethylene oxide added.
The fragrance used in each composition does not contain the component (C).

＊；口腔内の脱脂感が悪化することもなく、ほとんど感じられなかった。

*; The feeling of degreasing in the oral cavity did not worsen and was hardly felt.

As shown in Table 5, a polyhydric alcohol-based dentifrice composition having a water content of a specific value or less is blended with the component (A) and the components (B) and / or (C), and further (D) a cooling sensitizer. When was blended, the cooling sensation after brushing was stronger than that of the water-based dentifrice composition (control dentifrice composition), and the result was that it was noticeably felt. In addition, in these, a gentle feeling of warmth was felt at the beginning of brushing, and the feeling of warmth gradually changed to a feeling of coolness, and a unique feeling of use was recognized that the feeling of coolness became conspicuous after use. ..

Next, a prescription example (dentifrice) of the polyhydric alcohol-based dentifrice composition is shown. Each dentifrice composition was prepared in the same manner using the same raw materials as described above. The numerical value indicating the blending amount of each component is the pure amount.

[Prescription example 1]
(A) Sodium tetradecene sulfonate 1.0
(Product name: K Liporan PJ-400CJ)
(B) Coconut oil fatty acid amide propyl betaine 1.0
(Product name: TEGO BETAIN CK D)
(C) Polyoxyethylene (20) Hardened castor oil 1.0
(Product name: NIKKOL HCO-20)
Concentrated glycerin (99.5%) 75.1
Carboxyvinyl polymer (trade name: Carbopol 980)
0.5
Dl-α-tocopherol acetate 0.2
Allantoin 0.1
Saccharin sodium 0.1
Viscous silica 3.0
Abrasive silica 17.0
Fragrance 1.0
Total 100.0%
Moisture content in composition 0.4%

[Prescription example 2]
(A) Sodium tetradecene sulfonate 1.0
(Product name: K Liporan PJ-400CJ)
(B) Coconut oil fatty acid amide propyl betaine 1.0
(Product name: TEGO BETAIN CK D)
1,3-butylene glycol 30.0
Concentrated glycerin (99.5%) 46.2
Carboxyvinyl polymer (trade name: Carbopol 980)
0.5
Isopropylmethylphenol 0.1
Dipotassium glycyrrhizinate 0.1
Saccharin sodium 0.1
Viscous silica 3.0
Abrasive silica 17.0
Fragrance 1.0
Total 100.0%
Moisture content in composition 0.2%

[Prescription example 3]
(A) Sodium tetradecene sulfonate 1.0
(Product name: K Liporan PJ-400CJ)
(B) Coconut oil fatty acid amide propyl betaine 1.0
(Product name: TEGO BETAIN CK D)
1,3-butylene glycol 30.0
Concentrated glycerin (99.5%) 46.25
Carboxyvinyl polymer (trade name: Carbopol 980)
0.5
Isopropylmethylphenol 0.1
Tranexamic acid 0.05
Saccharin sodium 0.1
Viscous silica 3.0
Abrasive silica 17.0
Fragrance 1.0
Total 100.0%
Moisture content in composition 0.2%

[Prescription example 4]
(A) Sodium tetradecene sulfonate 1.0
(Product name: K Liporan PJ-400CJ)
(B) Coconut oil fatty acid amide propyl betaine 1.0
(Product name: TEGO BETAIN CK D)
Polyethylene glycol 400 30.0
Concentrated glycerin (99.5%) 46.5
Sodium Carboxymethyl Cellulose 0.1
Xanthan gum 0.1
Carrageenan 0.1
Isopropylmethylphenol 0.1
Saccharin sodium 0.1
Viscous silica 3.0
Abrasive silica 17.0
Fragrance 1.0
Total 100.0%
Moisture content in composition 0.2%

[Prescription example 5]
(A) Sodium tetradecene sulfonate 1.0
(Product name: K Liporan PJ-400CJ)
(B) Coconut oil fatty acid amide propyl betaine 1.0
(Product name: TEGO BETAIN CK D)
(C) Polyoxyethylene (20) Hardened castor oil 1.0
(Product name: NIKKOL HCO-20)
Polyethylene glycol 600 15.0
Concentrated glycerin (99.5%) 60.5
Sodium Carboxymethyl Cellulose 0.1
Xanthan gum 0.1
Carrageenan 0.1
Isopropylmethylphenol 0.1
Saccharin sodium 0.1
Viscous silica 3.0
Abrasive silica 17.0
Fragrance 1.0
Total 100.0%
Moisture content in composition 0.3%

Claims (8)

(A) α-olefin sulfonate and
A polyhydric alcohol containing one or more selected from (B) betaine-type amphoteric surfactant and (C) nonionic surfactant, and having a water content of 2% by mass or less. System dentifrice composition. (B) The polyhydric alcohol-based dentifrice composition according to claim 1, wherein the betaine-type amphoteric tenside is selected from fatty acid amide propyl betaine, alkyl acetate betaine and alkyl imidazolinium betaine having an alkyl group having 10 to 16 carbon atoms. Stuff. (C) The polyhydric alcohol according to claim 1 or 2, wherein the nonionic surfactant is selected from polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, alkyl glucoside, fatty acid polyglyceryl and polyoxyethylene polyoxypropylene copolymer. System dentifrice composition. The polyhydric alcohol-based dentifrice composition according to any one of claims 1 to 3, which contains 0.1 to 3% by mass of the component (A). (B) The polyhydric alcohol-based dentifrice composition according to any one of claims 1 to 4, wherein when the betaine-type amphoteric surfactant is contained, the content thereof is 0.1 to 3% by mass. (C) The polyhydric alcohol-based dentifrice composition according to any one of claims 1 to 5, wherein when the nonionic surfactant is contained, the content thereof is 0.05 to 2% by mass. The polyhydric alcohol-based dentifrice composition according to any one of claims 1 to 6, which contains 13 to 95% by mass of a polyhydric alcohol. The polyhydric alcohol-based dentifrice composition according to any one of claims 1 to 7, further comprising (D) a cooling sensation agent in an amount of 0.0001 to 0.3% by mass.