WO2022064598A1

WO2022064598A1 - Polyhydric alcohol-based dentifrice composition

Info

Publication number: WO2022064598A1
Application number: PCT/JP2020/036035
Authority: WO
Inventors: 麻衣小幡; 健太鈴木; 敬二石黒
Original assignee: ライオン株式会社
Priority date: 2020-09-24
Filing date: 2020-09-24
Publication date: 2022-03-31
Also published as: CN116249512A; JPWO2022064598A1

Abstract

Provided is a polyhydric alcohol-based dentifrice composition that provides a mild actual sensation of warmth immediately after being used in the mouth and that has a fine use feeling through reduction in the feel of in-mouth delipidation.　This polyhydric alcohol-based dentifrice composition contains one or more selected from (A) an α-olefin sulfonate, (B) a betaine-type amphoteric surfactant, and (C) a nonionic surfactant, and has a water content of 2 mass% or less. The polyhydric alcohol-based dentifrice composition further contains a specific amount of (D) a cooling sensation agent.

Description

Multivalent alcohol dentifrice composition

The present invention relates to a polyhydric alcohol-based dentifrice composition that gives a gentle warmth feeling immediately after use in the oral cavity and has a good feeling of use.

In oral compositions, especially dentifrice compositions, it is effective to increase the added value by giving an appropriate warmth as a feeling of use in the oral cavity from the viewpoint of improving the effect feeling by brushing teeth and further habituating it. Is. Various warming stimulants are used as means for giving a warming effect. For example, warming stimulants such as capsicum and ginger may cause unpleasant irritation depending on the composition, and the amount used may be increased. When it was reduced, it became impossible to sufficiently give a feeling of warmth, and it was difficult to give a feeling of mild warmth with low irritation satisfactorily.

As a toothpaste composition that gives a feeling of warmth, Patent Document 1 (Japanese Unexamined Patent Publication No. 2018-145163) describes an anionic surfactant selected from a water-soluble polyvalent metal salt, an alkyl sulfate, and an α-olefin sulfonate. When a betaine-type surfactant, glycerin and water are blended in a dentifrice composition containing the above-mentioned metal, the astringency derived from the above metal is generated when the content of glycerin is 50% by mass or more and the mass ratio of glycerin / water is within a specific range. It is proposed that it is suppressed and a warm feeling (warm feeling felt by the toothpaste during brushing) is obtained, the foam is quickly dispersed and there is no discomfort (dry feeling) in the oral cavity, and water-soluble multivalent such as aluminum lactate. An dentifrice composition containing 3.3% by mass or more of a metal salt, sodium lauryl sulfate, glycerin, coconut oil fatty acid amide propylbetaine, and water is described as an example, but it still gives a feeling of warmth. There was room for improvement.

By the way, for oral care, not only a general water-based dentifrice composition containing water but also a non-water-based dentifrice composition containing no water as a liquid medium is used, but the non-water-based dentifrice composition is used. There was a problem that the dispersibility in the oral cavity was poor and it was difficult to quickly develop the action effect and the feeling of effect.

Patent Documents 2 to 4 (Japanese Patent Laid-Open Nos. 2006-282550, 2006-182707, 2006-8530) contain a specific polyhydric alcohol as a tooth whitening component in a non-aqueous dentifrice composition. It is proposed that when it is blended, applied to teeth with an application tool, and further brushed, it has an excellent tooth whitening effect and good dispersibility in the oral cavity. Patent Document 5 (Japanese Unexamined Patent Publication No. 2014-521007) is a non-aqueous dentifrice composition containing a specific surfactant system and having good mouthfeel, dispersion of bubbles, etc., Patent Documents 6 to 9 (Patent No. 3640967). Japanese Patent Application Laid-Open No. 2002-302249, Japanese Patent Application Laid-Open No. 2002-255772, International Publication No. 2018/069054) describes the stability of a non-aqueous oral composition using a carboxyvinyl polymer or a specific polyvinylpyrrolidone. We propose improvement, taste improvement with baking soda, stability improvement with activator and alkali metal phosphate, etc. However, Patent Documents 2 to 9 do not mention the feeling of warmth.

Japanese Unexamined Patent Publication No. 2018-145163 Japanese Unexamined Patent Publication No. 2006-282550 Japanese Unexamined Patent Publication No. 2006-182707 Japanese Unexamined Patent Publication No. 2006-8530 Japanese Unexamined Patent Publication No. 2014-521707 Japanese Patent No. 3640967 Japanese Unexamined Patent Publication No. 2002-302249 Japanese Unexamined Patent Publication No. 2002-255772 International Publication No. 2018/069054

The present invention has been made in view of the above circumstances, and even if a warmth stimulant is not used, a gentle warmth feeling is given immediately after use in the oral cavity, and the degreasing feeling in the oral cavity is reduced and the feeling of use is also improved. It is an object of the present invention to provide a good polyhydric alcohol-based dentifrice composition.

As a result of diligent studies to achieve the above object, the present inventors have added (A) α-olefin sulfonate to a polyhydric alcohol-based dentifrice composition having a water content of 2% by mass or less. When B) betaine-type amphoteric surfactant and (C) one or more selected from nonionic surfactants are used in combination, the feeling of warmth in the oral cavity rises quickly and is gentle from the start of use. It has been found that a feeling of warmth can be given, a feeling of degreasing in the oral cavity after use is reduced and improved, and a good feeling of use can be maintained, and the present invention has been made.

More specifically, in a dentifrice composition in which the main component of the liquid medium is polyhydric alcohol, the lower the water content, the more heat of hydration is generated when it comes into contact with water when brushing teeth, and the heat of hydration causes the heat of hydration into the oral cavity. It was thought to give a feeling of warmth, but on the other hand, as the amount of water decreased, the dispersibility and foaming in the oral cavity became worse, and it was not possible to give a feeling of effect quickly.
On the other hand, in the present invention, in a polyhydric alcohol-based dentifrice composition having a substantially non-aqueous composition having a water content of 2% by mass or less, the component (A) and the components (B) and / or (C) By combining with, the above-mentioned specific surfactant system was able to give a gentle warmth sensation (a sensation that the oral mucosa takes on a gentle warmth different from the warmth stimulus). In this case, in the non-aqueous composition as described above, if an anionic surfactant, particularly sodium lauryl sulfate, which is an alkyl sulfate, is added to improve the dispersibility and foaming in the oral cavity, the oral cavity is degreased after use. The sensation (unpleasant sensation of degreasing oil on the tongue and oral mucosa) was exacerbated, causing the problem of unsuitability for use. However, by using the component (A) as an anionic surfactant and combining the component (B) and / or the component (C) with the component (A), the feeling of degreasing in the oral mucosa is exacerbated as described above. It was possible to satisfactorily give a gentle warmth feeling immediately after the start of use, while maintaining a good feeling of use.
Further, when (D) a cooling sensation agent was added, in addition to the above-mentioned gentle feeling of warmth, it was possible to give a remarkable cooling sensation after use.
The action and effect of the present invention are specific to the above-mentioned specific surfactant system, and as shown in the comparative example described later, when the component (A) is lacking or the components (B) and (C) are lacking. The onset of warmth at the start of use or the lack of degreasing in the oral cavity after use was inferior, and this effect was inferior when an inappropriate surfactant was combined and blended. On the other hand, as shown in Examples described later, a polyhydric alcohol-based toothpaste containing the component (A) and the components (B) and / or (C) of the present invention and having a water content of a specific value or less. The agent composition was excellent in that there was no feeling of degreasing in the oral cavity after use and that the feeling of warmth at the start of use started to rise.

Therefore, the present invention provides the following polyhydric alcohol-based dentifrice composition.
[1]
(A) α-olefin sulfonate and
A polyhydric alcohol-based dentifrice composition containing one or more selected from (B) betaine-type amphoteric surfactant and (C) nonionic surfactant, and having a water content of 2% by mass or less. ..
[2]
(B) The polyhydric alcohol-based dentifrice according to [1], wherein the betaine-type amphoteric tenside agent is selected from fatty acid amide propyl betaine having an alkyl group having 10 to 16 carbon atoms, alkyl acetate betaine and alkyl imidazolinium betaine. Composition.
[3]
(C) The nonionic surfactant is selected from polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, alkyl glucoside, fatty acid polyglyceryl and polyoxyethylene polyoxypropylene copolymer according to [1] or [2]. Polyhydric alcohol-based dentifrice composition.
[4]
(A) The polyhydric alcohol-based dentifrice composition according to any one of [1] to [3], which contains 0.1 to 3% by mass of the component.
[5]
(B) The polyhydric alcohol-based dentifrice composition according to any one of [1] to [4], wherein when the betaine-type amphoteric surfactant is contained, the content thereof is 0.1 to 3% by mass.
[6]
(C) The polyhydric alcohol-based dentifrice composition according to any one of [1] to [5], wherein when the nonionic surfactant is contained, the content thereof is 0.05 to 2% by mass.
[7]
The polyhydric alcohol-based dentifrice composition according to any one of [1] to [6], which contains 13 to 95% by mass of polyhydric alcohol.
[8]
The polyhydric alcohol-based dentifrice composition according to [7], wherein the polyhydric alcohol is glycerin or a combination system of glycerin and polyethylene glycol having an average molecular weight of 190 to 630.
[9]
The polyhydric alcohol-based dentifrice composition according to any one of [1] to [8], which further contains (D) a cooling sensation agent in an amount of 0.0001 to 0.3% by mass.
[10]
The polyhydric alcohol-based dentifrice composition according to any one of [1] to [9], which is a dentifrice or a gel dentifrice.

According to the present invention, it is possible to provide a polyhydric alcohol-based dentifrice composition that gives a gentle feeling of warmth in the oral cavity immediately after use, reduces the feeling of degreasing in the oral cavity, and has a good taste. The polyhydric alcohol-based dentifrice composition of the present invention does not require the addition of stimulating warming components such as capsicum and ginger, which are relatively irritating as warming agents, and provides a mild warming sensation with low irritation. It can be imparted, and by further adding (D) a cooling sensation agent, a gentle warming sensation rises at the start of use, and it is also possible to impart a unique feeling of use in which the cooling sensation gradually becomes conspicuous. Is.

Hereinafter, the present invention will be described in more detail.
The polyhydric alcohol-based dentifrice composition of the present invention comprises one or more selected from (A) α-olefin sulfonate, (B) betaine-type amphoteric surfactant and (C) nonionic surfactant. And the water content is 2% by mass or less.
Further, in the present invention, the "defatting sensation" is an unpleasant sensation that the oil on the tongue and the oral mucosa has been deprived, and the "warm sensation" is a sensation that the oral mucosa is warm.

In the present invention, the "polyhydric alcohol-based dentifrice composition" is a dentifrice composition containing a polyhydric alcohol as a main component of a liquid medium as a base. The dentifrice composition in which the main component of a general liquid medium is water is "water-based".
As the polyhydric alcohol, a polyhydric alcohol that is liquid at 25 ° C., which generates heat of hydration when in contact with water, can be used. Specific examples thereof include glycerin, polyethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, polypropylene glycol and the like having an average molecular weight of 190 to 630 (average molecular weight described in the non-medicinal product raw material standard 2006, the same applies hereinafter). Among these, glycerin, polyethylene glycol having an average molecular weight of 190 to 630, and butylene glycol are preferable from the viewpoint of raising a feeling of warmth and improving the feeling of degreasing in the oral cavity.
As the polyethylene glycol having the specific average molecular weight, for example, polyethylene glycol 200 (average molecular weight 190 to 210), polyethylene glycol 400 (average molecular weight 380 to 420), and polyethylene glycol 600 (average molecular weight 570 to 630) can be used. can.
Polyhydric alcohols have their own bitterness, but glycerin is a polyhydric alcohol with relatively little bitterness. Therefore, from the viewpoint of reducing the bitterness derived from the liquid medium, it contains at least glycerin, and the content of glycerin is 20 to 100% (mass%, the same applies hereinafter), particularly 50 to 85%, and further 50 to 80% of the total polyhydric alcohol. Is more preferable.
In addition, among polyhydric alcohols, polyethylene glycol having the specific average molecular weight contributes relatively strongly to the feeling of warmth. Therefore, from the viewpoint of the strength of the feeling of warmth, it is preferable to contain at least the polyethylene glycol, and it is more preferable that the content of the polyethylene glycol is 10% or more, particularly 15 to 30% of the whole composition. If it exceeds 30%, the bitterness derived from polyethylene glycol may affect the usability, but if it is 30% or less, a good usability can be maintained.
In the present invention, the polyhydric alcohol is a combination system of glycerin and polyethylene glycol and / or butylene glycol having an average molecular weight of 190 to 630, particularly a combination system of glycerin and polyethylene glycol having an average molecular weight of 190 to 630, and further, glycerin. When the content of the polyhydric alcohol is 50% or more, particularly 50 to 85% of the total polyhydric alcohol, it is particularly preferable from the viewpoint of exhibiting the effect of the present invention.

The larger the amount of the polyhydric alcohol, the higher the feeling of warmth, but from the viewpoint of the rise of the feeling of warmth and the improvement of the degreasing feeling in the oral cavity, 13 to 95% of the whole composition is preferable, and more preferably 20 to 90. %, Especially preferably 25 to 85%, still more preferably 30 to 80%, and even 50 to 80%.

Further, the polyhydric alcohol-based dentifrice composition of the present invention has a water content of 2% or less, may be less than 2%, preferably 1% or less, particularly 0, from the viewpoint of expressing a feeling of warmth. It is less than 5.5%. The lower the water content, the more preferable, and water may not be added and the addition amount may be 0%. This polyhydric alcohol-based dentifrice composition is preferably a non-water composition that does not contain water, but even if water is not added to the composition, for example, water is contained in the raw materials of other compounding components. If so, this water will be brought in, and water may be brought in due to pH adjustment or moisture absorption of raw materials, etc., so in consideration of these waters, the allowable upper limit of water is specified as described above. be. Therefore, the "substantially non-aqueous composition" described here means that the amount of water in the composition is equal to or less than the above value.
In the present invention, by using a substantially non-water base mainly composed of the polyhydric alcohol as described above, this substantially non-aqueous composition of the polyhydric alcohol-based dentifrice composition is watered when used in the oral cavity. The heat of hydration is generated by contact with, and a gentle warmth can be given to the oral cavity, and the above-mentioned warmth feeling can be given even if a stimulating warmth component such as toothpaste is not blended. Can be done.

(A) The α-olefin sulfonate has an effect of improving the rise of the feeling of warmth.
As the α-olefin sulfonic acid salt, an alkali metal salt such as sodium or potassium of α-olefin sulfonic acid having 14 to 16 carbon atoms can be used, and an α-olefin sulfonic acid salt having 14 carbon atoms is particularly preferable. It is a sodium salt (generic name; sodium tetradecene sulfonate). For these, commercially available products that can be used for oral preparations can be obtained, and for example, the trade name "K Liporan PJ-400CJ" manufactured by Lion Specialty Chemicals Co., Ltd. can be used.

The blending amount of the (A) α-olefin sulfonate is preferably 0.1 to 3%, more preferably 0.5 to 2% of the entire composition. When the blending amount is 0.1% or more, the dispersibility of the pharmaceutical product in the oral cavity at the time of use is improved, and a sufficient rise in a feeling of warmth can be obtained. When it is 3% or less, the feeling of degreasing in the oral cavity after use is sufficiently reduced.

In addition, (B) betaine-type amphoteric surfactant and (C) nonionic surfactant each have an effect of reducing and improving the feeling of degreasing in the oral cavity due to the component (A), and in particular, the component (B) is , (A) also has the effect of accelerating the rise of the feeling of warmth.
In the present invention, any one of the components (B) and (C) may be blended, but it is preferable to blend the component (B) from the viewpoint of the rise of the feeling of warmth, and in particular (B). And (C) are more preferable from the viewpoint of improving the feeling of degreasing in the oral cavity and raising the feeling of warmth.

(B) The betaine-type amphoteric tenside agent preferably has an alkyl group having 10 to 16 carbon atoms, and is a fatty acid amide propyl betaine having the alkyl group, an alkyl acetate betaine having the alkyl group, and an alkyl having the alkyl group. Imidazolinium betaine can be used.
Specifically, the fatty acid amide propyl betaine includes coconut oil fatty acid amide propyl betaine and the like, the alkyl acetate betaine includes lauryldimethylamino acetate betaine and the like, and the alkylimidazolinium betaine includes alkylcarboxymethyl hydroxyethyl imidazolinium betaine and the like. Can be mentioned. Among these, fatty acid amide propyl betaine and alkyl acetate betaine, particularly fatty acid amide propyl betaine coconut oil fatty acid amide propyl betaine are preferable. In the present invention, since the water content in the dentifrice composition is defined as 2% or less, it is preferable to use a solution or powder having a pure content (betaine pure content) of 65% or more as the betaine-type surfactant. ..
These can be used alone or in combination of two or more. Moreover, a commercially available product can be used.

Examples of the (C) nonionic surfactant include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, alkyl glucoside, fatty acid polyglyceryl, and polyoxyethylene polyoxypropylene (EOPO) copolymer. Further, the polyoxyethylene hydrogenated castor oil preferably has an average number of moles of ethylene oxide added of 5 to 100, particularly 5 to 60. The polyoxyethylene alkyl ether has an average number of moles of ethylene oxide added of 5 to 30, and preferably an alkyl group having 12 to 18 carbon atoms. Specific examples thereof include polyoxyethylene lauryl ether and polyoxyethylene stearyl ether in which the average number of moles of ethylene oxide added is in the above range. The polyoxyethylene polyoxypropylene (EOPO) copolymer preferably has an average added mole number of ethylene oxide of 20 to 210 and an average added mole number of propylene oxide of 15 to 60, and may be a block copolymer or a random copolymer.
Among these, polyoxyethylene hydrogenated castor oil and polyoxyethylene alkyl ether are preferable, and polyoxyethylene hydrogenated castor oil having an average addition molar number of 5 to 60 of ethylene oxide is particularly preferable.
These may be used alone or in combination of two or more. Moreover, a commercially available product can be used.

When the component (B) is blended, the blending amount thereof is preferably 0.1 to 3%, more preferably 0.3 to 2% of the entire composition. When the blending amount is 0.1% or more, the degreasing feeling in the oral cavity is sufficiently improved, and the rise of the feeling of warmth is improved. When it is 3% or less, the bitterness due to itself is suppressed and a good feeling of use can be sufficiently maintained.

When the component (C) is blended, the blending amount thereof is preferably 0.05 to 2%, more preferably 0.5 to 1% of the total composition. When the blending amount is 0.05% or more, the feeling of degreasing in the oral cavity is sufficiently improved. When it is 2% or less, the bitterness due to itself is suppressed and a good feeling of use can be sufficiently maintained.
When the component (B) and the component (C) are used in combination, each can be blended within the above range.

In the present invention, in addition to the component (A) and the components (B) and / or (C), a surfactant other than these may be blended as long as the effect of the present invention is not impaired.
Examples of the optional surfactant include anionic surfactants other than the component (A), for example, an acyl amino acid salt, an acyl taurine or a salt thereof, and an alkyl sulfate such as sodium lauryl sulfate. The blending amount of these arbitrary anionic surfactants is preferably 0 to 0.3% of the total composition from the viewpoint of the rise of a feeling of warmth and the absence of a feeling of degreasing in the oral cavity. It is preferable not to add an alkyl sulfate such as sodium lauryl sulfate from the viewpoint of no feeling of degreasing in the oral cavity, and when it is added, the amount thereof is preferably 0.3% or less of the whole composition.

In the present invention, when (D) a cooling sensation agent is further added, it is possible to give a moderately strong and outstanding cooling sensation to the oral cavity after use. In this case, by blending the component (A) and the component (B) and / or the component (C) and the component (D), a gentle feeling of warmth rises and is sufficiently felt at the start of use, and this feeling of warmth is felt sufficiently. However, as time goes by, it gradually changes to a cool feeling, and after use, the cool feeling stands out, which can give a unique feeling of use that changes the sensation.

(D) Examples of the cooling sensitizer include menthol derivatives such as carboxamide, alcohols, esters, and menthol derivatives having an ether structure. Specifically, N-ethyl-p-mentane-3-carboxamide, ethyl-3- (p-mentane-carboxamide) acetate, mentyl lactate, mentyl monosuccinate, isopregol, mentonglycerol ketal, N- (4-cyano). Methylphenyl) -p-menthanecarboxamide, 2-isopropyl-5-methyl-N- (2- (pyridine-4-yl) ethyl) cyclohexanecarboxamide, 3-l-mentoxypropane-1,2-diol and the like. However, among them, N-ethyl-p-menthane-3-carboxamide and N- (4-cyanomethylphenyl) -p-menthanecarboxamide are preferable from the viewpoint of imparting a cooling sensation.
These may be used alone or in combination of two or more. Moreover, a commercially available product can be used.

The blending amount of the component (D) is preferably 0.0001 to 0.3%, more preferably 0.001 to 0.2%, still more preferably 0.01 to 0.1% of the entire composition. Within this range, a feeling of coolness can be sufficiently obtained, and irritation and bitterness due to itself can be sufficiently suppressed, and a feeling of use can be sufficiently maintained.

The polyhydric alcohol-based dentifrice composition of the present invention can be formed into a paste-like or gel-like shape, and can be particularly prepared as a dentifrice or a gel dentifrice. Further, in addition to the above-mentioned components, other known components according to the dosage form and the like can be blended as needed, and these can be used as long as the effects of the present invention are not impaired. For example, abrasives, binders, oily ingredients, flavors, sweeteners, preservatives, colorants, active ingredients and the like can be mentioned.

Examples of the abrasive include silica-based abrasives such as precipitated silica, silica gel, aluminosilicate, and zirconosilicate, calcium carbonate, calcium phosphate, aluminum silicate, and aluminum hydroxide. The blending amount of the abrasive is usually 0 to 70%, particularly 2 to 30% of the whole composition.

As the binder, an organic binder such as a water-soluble polymer or an inorganic binder can be used.
Examples of the organic binder include cellulose derivatives such as sodium carboxymethyl cellulose, gums such as xanthan gum, tragant gum, karaya gum and arabia gum, carboxyvinyl polymers, polyvinyl alcohol, crosslinked sodium polyacrylate, carrageenan, sodium alginate and polyvinylpyrrolidone. Be done. Examples of the inorganic binder include thickening silica such as precipitate silica, igneable silica, gelling silica and gelling aluminum silica, and clay minerals such as bee gum, laponite and bentonite. The blending amount of the binder is usually 0.1 to 10%, particularly 0.2 to 5% of the whole composition.
The binder is preferably an organic binder, particularly a carboxyvinyl polymer, and the blending amount thereof is preferably 0.1 to 3%, particularly 0.3 to 2% of the entire composition.

Oily components include hydrocarbons (squalane, liquid paraffin, vaseline, microcrystallin wax, etc.), higher alcohols with 8 to 22 carbon atoms (lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, isostearyl alcohol, etc.), carbon. Examples thereof include higher fatty acids (lauric acid, myristic acid, oleic acid, isostearic acid, etc.), vegetable oils (olive oil, castor oil, palm oil, etc.), fatty acid esters (isopropyl myristate, etc.) having a number of 8 to 22.

The fragrances are peppermint oil, sparemint oil, anis oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamon oil, coriander oil, mandarin oil, lime. Oil, lavender oil, rosemary oil, laurel oil, camomill oil, caraway oil, majorum oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute peppermint , Absolute rose, orange flower and other natural fragrances, and processed fragrances (pre-reservoir cut, rear-reservoir cut, distilling, liquid extraction, essence, powder fragrance, etc.) and menthol. , Carvone, Anetol, Cineol, Methyl salicylate, Synamic aldehyde, Eugenol, 3-l-Mentoxypropane-1.2-diol, Timor, Linarol, Linalyl acetate, Limonen, Menton, Menthyl acetate, N-substituted-Peppermint -3-Carboxamide, Peppermint, Octylaldehyde, Citral, Pregon, Calvia Acetate, Anisaldehyde, Ethylacetate, Ethylbutyrate, Allylcyclohexanepropionate, Methylanthranilate, Ethylmethylphenylglycidate, Vanillin, Undecalactone , Hexanal, propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethylsulfide, cycloten, furfural, trimethylpyrazine, ethyllactate, methyllactate, ethylthioacetate and other single fragrances, as well as strawberry flavor, apple flavor, banana flavor and pineapple flavor. , Grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor and other compounded fragrances, and known fragrance materials used in dentifrice compositions can be used.
It is preferable to use 0.000001 to 1% of the above fragrance material in the composition, and 0.1 to 2.0% of the fragrance for perfume using the above fragrance material is used in the composition. good.

Examples of the sweetener include saccharin sodium, stebioside, stevia extract, neohesperidyl dihydrochalcone, glycyrrhizin, perillartine, p-methoxycinnamic aldehyde, aspartame, xylitol and the like.
Examples of the preservative include paraoxybenzoic acid esters such as butylparaben, propylparaben and ethylparaben, and sodium benzoate.
Examples of the colorant include Blue No. 1, Blue No. 4, Green No. 3 and the like.

The active ingredient is a fluorine-containing compound such as sodium monofluorophosphate and sodium fluoride; a water-soluble phosphoric acid compound such as a potassium salt of orthophosphoric acid and a sodium salt; Enzymes such as stranase, mutanase, protease; copper compounds such as copper gluconate; chelate phosphate compounds such as glycerophosphate; cationic bactericides such as cetylpyridium chloride, benzethonium chloride, benzalkonium chloride; isopropylmethylphenol Non-ionic bactericides such as; Touki soft extract; Oubaku extract; Extracts such as chamomile, chowji, rosemary, ginger, benibana, tranexamic acid, hinokithiol, sodium chloride, dl-α-tocopherol acetate, coenzyme Q10, dihydro Cholesterol, α-bisabolol, chlorhexidine salts, triclosan, sanginaline extract, azulene, glycyrrhizin, glycyrrhetinic acid, copper chlorophyllin sodium, chlorophyll, strontium chloride, velverin, hydroxamic acid or its derivatives, pyrophosphate, tripolyphosphate, zeolite, methoxy Examples thereof include ethylene anhydride maleic acid copolymer, epidihydrocholesterin, trichlorocarbanilide, and zinc citrate. These can be blended in an effective amount within a range that does not interfere with the effects of the present invention.

Hereinafter, the present invention will be specifically described with reference to Examples, Comparative Examples, and Prescription Examples, but the present invention is not limited to the following Examples. In the following examples,% indicates mass% unless otherwise specified.

[Examples, comparative examples]
Polyhydric alcohol-based dentifrice compositions (dentifrices) having the compositions shown in Tables 1 to 5 were prepared by a conventional method, and the evaluations shown in each table were performed by the following methods. The results are also shown in the table. In the table, the numerical value indicating the blending amount of each component is the pure content.
The dentifrice compositions shown in Tables 1 to 5 are substantially non-aqueous compositions having a water content of 2% or less.

<Evaluation method>
(1) Evaluation method for the lack of degreasing in the oral cavity after use Ten testers placed 1 g of the dentifrice composition on a toothbrush, brushed it for 3 minutes using a normal method, and rinsed it with water in the oral cavity. The lack of degreasing feeling was judged on a 5-point scale according to the scoring criteria shown below.
The average score of 10 testers was calculated, evaluated according to the evaluation criteria shown below, and shown in the table with ☆, ◎, ○, Δ, and ×.
Here, the "defatting sensation" is an unpleasant sensation that the oil on the tongue and oral mucosa has been deprived.
Score criteria 5 points: No feeling of degreasing in the oral cavity 4 points: Almost no feeling of degreasing in the oral cavity 3 points: Slightly feeling of degreasing in the oral cavity, but not noticeable 2 points: Oral cavity Feel the degreasing feeling in the inside 1 point: Feel the degreasing feeling in the oral cavity strongly Evaluation criteria ☆: Average 4.5 points or more and 5.0 points or less ◎: Average 4.0 points or more and less than 4.5 points ○: Average 3. 0 points or more and less than 4.0 points Δ: Average 2.0 points or more and less than 3.0 points ×: Average 1.0 points or more and less than 2.0 points

(2) Evaluation method of the rise of the feeling of warmth at the start of use When 10 testers put 1 g of the dentifrice composition on the toothbrush and started brushing by the usual method, the rise of the feeling of warmth in the oral cavity was measured. , Judgment was made in 5 stages according to the scoring criteria shown below.
The average score of 10 testers was calculated, evaluated according to the evaluation criteria shown below, and indicated by ⊚, ◯, Δ, and × in the table.
Here, the "feeling of warmth" is the feeling that the oral mucosa has a gentle warmth different from the stimulation of warmth, and the "rise of feeling of warmth" is the above-mentioned temperature after the start of brushing. It means the speed until you can feel the feeling.
Score criteria 5 points: Very fast rise of warmth feeling 4 points: Fast rise of warmth feeling 3 points: Slightly fast rise of warmth feeling 2 points: Slow rise of warmth feeling 1 point: Warm feeling Evaluation criteria with a very slow rise in actual feeling ◎: Average 4.0 points or more and 5.0 points or less ○: Average 3.0 points or more and less than 4.0 points △: Average 2.5 points or more and less than 3.0 points ×: Average 1.0 points or more and less than 2.5 points

(3) Evaluation method of no bitterness during use Ten testers put 1 g of the dentifrice composition on a toothbrush and brushed it with a normal method, and the bitterness felt in the oral cavity (betaine-type amphoteric interface, which is a compounding ingredient). The active agent, the nonionic surfactant, and the unique bitterness derived from the cooling sensitizer) were judged on a 5-point scale according to the scoring criteria shown below.
The average score of 10 testers was calculated, evaluated according to the evaluation criteria shown below, and indicated by ⊚, ◯, Δ, and × in the table.
Score criteria 5 points: No bitterness 4 points: Almost no bitterness 3 points: Slightly bitter but not noticeable 2 points: Bitterness 1 point: Strong bitterness Evaluation criteria ◎: Average score 4.0 points or more and 5.0 points or less ○: Average points 3.0 points or more and less than 4.0 points Δ: Average points 2.0 points or more and less than 3.0 points ×: Average points 1.0 points or more and 2.0 points Less than a point

(4) Evaluation method of the cool feeling in the oral cavity after use Ten testers put 1 g of the dentifrice composition on a toothbrush, brushed it for 3 minutes by the usual method, and rinsed it with water to cool the oral cavity. The feeling was compared with the control dentifrice composition and judged on a 5-point scale according to the scoring criteria shown below. The control dentifrice composition is a water-based dentifrice composition (dentifrice) having the same composition except that water is added instead of the concentrated glycerin of each composition.
The average score of 10 testers was calculated, evaluated according to the evaluation criteria shown below, and indicated by ⊚, ◯, Δ, and × in the table.
Here, the "cool feeling" indicates an appropriate cool feeling that is felt after gargle the mouth.
Score criteria 5 points: Very strong cool feeling 4 points: Strong cool feeling 3 points: Slightly strong cool feeling 2 points: Equivalent cool feeling 1 point: Weak cool feeling Evaluation criteria ◎: Average 4.0 points 5.0 points or less ○: Average 2.5 points or more and less than 4.0 points △: Average 2.0 points or more and less than 2.5 points ×: Average 1.0 points or more and less than 2.0 points

The following were used as the component (A), the component (B), the component (C), and the component (D).
(A) component;
Sodium tetradecene sulfonate (manufactured by Lion Specialty Chemicals Co., Ltd., trade name: K Liporan PJ-400CJ)
(B) component;
Palm oil fatty acid amide propyl betaine (manufactured by Evonik, trade name: TEGO BETAIN CK D, composition in the product (palm oil fatty acid amide propyl betaine: sodium chloride: water = 85: 14.5: 0.5, betaine pure content 85%) )))
Betaine lauryldimethylaminoacetate (manufactured by Sigma-Aldrich, trade name: (Lauryldimethyllaminio) acetate, betaine pure content ≥95%)
(C) component;
Polyoxyethylene (20) hardened castor oil (manufactured by Nippon Surfactant Industry Co., Ltd., trade name: NIKKOL HCO-20)
Polyoxyethylene (5) Stearyl Ether (manufactured by Aoki Oil & Fat Industry Co., Ltd., trade name: Blaunon SR-705)
(D) component;
N-Ethyl-p-Menthane-3-carboxamide (manufactured by Givaudan, trade name: WS-3)
N- (4-cyanomethylphenyl) -p-menthanecarboxamide (manufactured by Givaudan, trade name: Evercool (registered trademark) G-180)
As the carboxyvinyl polymer, a trade name: Carbopol (registered trademark) 980 manufactured by Lubrizol was used.
In polyoxyethylene hydrogenated castor oil and polyoxyethylene stearyl ether, the values in parentheses are the average number of moles of ethylene oxide added.
The fragrance used in each composition does not contain the component (C).

*; The feeling of degreasing in the oral cavity did not worsen and was hardly felt.

As shown in Table 5, a polyhydric alcohol-based dentifrice composition having a water content of a specific value or less is blended with a component (A) and a component (B) and / or a component (C), and further (D) a cooling sensitizer. When was blended, the cooling sensation after dentifrice was stronger than that of the water-based dentifrice composition (control dentifrice composition), and the result was that it was noticeably felt. In addition, in these, a gentle feeling of warmth was felt at the beginning of brushing, and the feeling of warmth gradually changed to a feeling of coolness, and a unique feeling of use was recognized that the feeling of coolness became conspicuous after use. ..

Next, a prescription example (dentifrice) of the polyhydric alcohol-based dentifrice composition is shown. In addition, each dentifrice composition was prepared in the same manner using the same raw materials as above. The numerical value indicating the blending amount of each component is the pure amount.

[Prescription example 1]
(A) Sodium tetradecene sulfonate 1.0
(Product name: K Liporan PJ-400CJ)
(B) Coconut oil fatty acid amide propyl betaine 1.0
(Product name: TEGO BETAIN CK D)
(C) Polyoxyethylene (20) Hardened castor oil 1.0
(Product name: NIKKOL HCO-20)
Concentrated glycerin (99.5%) 75.1
Carboxyvinyl polymer (trade name: Carbopol 980)
0.5
Acetic acid dl-α-tocopherol 0.2
Allantoin 0.1
Saccharin sodium 0.1
Viscous silica 3.0
Abrasive silica 17.0
Fragrance 1.0
Total 100.0%
Moisture content in composition 0.4%

[Prescription example 2]
(A) Sodium tetradecene sulfonate 1.0
(Product name: K Liporan PJ-400CJ)
(B) Coconut oil fatty acid amide propyl betaine 1.0
(Product name: TEGO BETAIN CK D)
1,3-butylene glycol 30.0
Concentrated glycerin (99.5%) 46.2
Carboxyvinyl polymer (trade name: Carbopol 980)
0.5
Isopropylmethylphenol 0.1
Dipotassium glycyrrhizinate 0.1
Saccharin sodium 0.1
Viscous silica 3.0
Abrasive silica 17.0
Fragrance 1.0
Total 100.0%
Moisture content in composition 0.2%

[Prescription example 3]
(A) Sodium tetradecene sulfonate 1.0
(Product name: K Liporan PJ-400CJ)
(B) Coconut oil fatty acid amide propyl betaine 1.0
(Product name: TEGO BETAIN CK D)
1,3-butylene glycol 30.0
Concentrated glycerin (99.5%) 46.25
Carboxyvinyl polymer (trade name: Carbopol 980)
0.5
Isopropylmethylphenol 0.1
Tranexamic acid 0.05
Saccharin sodium 0.1
Viscous silica 3.0
Abrasive silica 17.0
Fragrance 1.0
Total 100.0%
Moisture content in composition 0.2%

[Prescription example 4]
(A) Sodium tetradecene sulfonate 1.0
(Product name: K Liporan PJ-400CJ)
(B) Coconut oil fatty acid amide propyl betaine 1.0
(Product name: TEGO BETAIN CK D)
Polyethylene glycol 400 30.0
Concentrated glycerin (99.5%) 46.4
Sodium Carboxymethyl Cellulose 0.4
Isopropylmethylphenol 0.1
Saccharin sodium 0.1
Viscous silica 3.0
Abrasive silica 17.0
Fragrance 1.0
Total 100.0%
Moisture content in composition 0.2%

[Prescription Example 5]
(A) Sodium tetradecene sulfonate 1.0
(Product name: K Liporan PJ-400CJ)
(B) Coconut oil fatty acid amide propyl betaine 1.0
(Product name: TEGO BETAIN CK D)
(C) Polyoxyethylene (20) Hardened castor oil 1.0
(Product name: NIKKOL HCO-20)
Polyethylene glycol 600 15.0
Concentrated glycerin (99.5%) 60.4
Sodium Carboxymethyl Cellulose 0.4
Isopropylmethylphenol 0.1
Saccharin sodium 0.1
Viscous silica 3.0
Abrasive silica 17.0
Fragrance 1.0
Total 100.0%
Moisture content in composition 0.3%

Claims

(A) α-olefin sulfonate and
A polyhydric alcohol-based dentifrice composition containing one or more selected from (B) betaine-type amphoteric surfactant and (C) nonionic surfactant, and having a water content of 2% by mass or less. ..
(B) The polyhydric alcohol-based dentifrice composition according to claim 1, wherein the betaine-type amphoteric surfactant is selected from fatty acid amide propyl betaine having an alkyl group having 10 to 16 carbon atoms, alkyl acetate betaine and alkyl imidazolinium betaine. thing.
(C) The polyhydric alcohol according to claim 1 or 2, wherein the nonionic surfactant is selected from polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, alkyl glucoside, fatty acid polyglyceryl and polyoxyethylene polyoxypropylene copolymer. System of dentifrice composition.
The polyhydric alcohol-based dentifrice composition according to any one of claims 1 to 3, which contains 0.1 to 3% by mass of the component (A).
(B) The polyhydric alcohol-based dentifrice composition according to any one of claims 1 to 4, wherein the betaine-type amphoteric surfactant is contained in an amount of 0.1 to 3% by mass.
(C) The polyhydric alcohol-based dentifrice composition according to any one of claims 1 to 5, wherein when the nonionic surfactant is contained, the content thereof is 0.05 to 2% by mass.
The polyhydric alcohol-based dentifrice composition according to any one of claims 1 to 6, which contains 13 to 95% by mass of polyhydric alcohol.
The polyhydric alcohol-based dentifrice composition according to claim 7, wherein the polyhydric alcohol is glycerin or a combination system of glycerin and polyethylene glycol having an average molecular weight of 190 to 630.
The polyhydric alcohol-based dentifrice composition according to any one of claims 1 to 8, further comprising (D) a cooling sensation agent in an amount of 0.0001 to 0.3% by mass.
The polyhydric alcohol-based dentifrice composition according to any one of claims 1 to 9, which is a dentifrice or a gel dentifrice.