WO2022064598A1 - Composition de dentifrice à base d'alcool polyhydrique - Google Patents

Composition de dentifrice à base d'alcool polyhydrique Download PDF

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Publication number
WO2022064598A1
WO2022064598A1 PCT/JP2020/036035 JP2020036035W WO2022064598A1 WO 2022064598 A1 WO2022064598 A1 WO 2022064598A1 JP 2020036035 W JP2020036035 W JP 2020036035W WO 2022064598 A1 WO2022064598 A1 WO 2022064598A1
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Prior art keywords
polyhydric alcohol
dentifrice composition
feeling
betaine
based dentifrice
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PCT/JP2020/036035
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English (en)
Japanese (ja)
Inventor
麻衣 小幡
健太 鈴木
敬二 石黒
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ライオン株式会社
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Priority to JP2022551493A priority Critical patent/JPWO2022064598A1/ja
Priority to PCT/JP2020/036035 priority patent/WO2022064598A1/fr
Priority to CN202080105495.8A priority patent/CN116249512A/zh
Publication of WO2022064598A1 publication Critical patent/WO2022064598A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a polyhydric alcohol-based dentifrice composition that gives a gentle warmth feeling immediately after use in the oral cavity and has a good feeling of use.
  • compositions especially dentifrice compositions
  • it is effective to increase the added value by giving an appropriate warmth as a feeling of use in the oral cavity from the viewpoint of improving the effect feeling by brushing teeth and further habituating it.
  • Various warming stimulants are used as means for giving a warming effect.
  • warming stimulants such as capsicum and ginger may cause unpleasant irritation depending on the composition, and the amount used may be increased. When it was reduced, it became impossible to sufficiently give a feeling of warmth, and it was difficult to give a feeling of mild warmth with low irritation satisfactorily.
  • Patent Document 1 Japanese Unexamined Patent Publication No. 2018-145163 describes an anionic surfactant selected from a water-soluble polyvalent metal salt, an alkyl sulfate, and an ⁇ -olefin sulfonate.
  • a betaine-type surfactant, glycerin and water are blended in a dentifrice composition containing the above-mentioned metal, the astringency derived from the above metal is generated when the content of glycerin is 50% by mass or more and the mass ratio of glycerin / water is within a specific range.
  • Patent Documents 2 to 4 Japanese Patent Laid-Open Nos. 2006-282550, 2006-182707, 2006-8530 contain a specific polyhydric alcohol as a tooth whitening component in a non-aqueous dentifrice composition. It is proposed that when it is blended, applied to teeth with an application tool, and further brushed, it has an excellent tooth whitening effect and good dispersibility in the oral cavity.
  • Patent Document 5 Japanese Unexamined Patent Publication No. 2014-521007 is a non-aqueous dentifrice composition containing a specific surfactant system and having good mouthfeel, dispersion of bubbles, etc.
  • Patent Documents 6 to 9 Patent No. 3640967.
  • Patent Documents 2 to 9 do not mention the feeling of warmth.
  • the present invention has been made in view of the above circumstances, and even if a warmth stimulant is not used, a gentle warmth feeling is given immediately after use in the oral cavity, and the degreasing feeling in the oral cavity is reduced and the feeling of use is also improved. It is an object of the present invention to provide a good polyhydric alcohol-based dentifrice composition.
  • the present inventors have added (A) ⁇ -olefin sulfonate to a polyhydric alcohol-based dentifrice composition having a water content of 2% by mass or less.
  • B) betaine-type amphoteric surfactant and (C) one or more selected from nonionic surfactants are used in combination, the feeling of warmth in the oral cavity rises quickly and is gentle from the start of use. It has been found that a feeling of warmth can be given, a feeling of degreasing in the oral cavity after use is reduced and improved, and a good feeling of use can be maintained, and the present invention has been made.
  • the lower the water content the more heat of hydration is generated when it comes into contact with water when brushing teeth, and the heat of hydration causes the heat of hydration into the oral cavity. It was thought to give a feeling of warmth, but on the other hand, as the amount of water decreased, the dispersibility and foaming in the oral cavity became worse, and it was not possible to give a feeling of effect quickly.
  • a polyhydric alcohol-based dentifrice composition having a substantially non-aqueous composition having a water content of 2% by mass or less the component (A) and the components (B) and / or (C)
  • the component (A) and the components (B) and / or (C) By combining with, the above-mentioned specific surfactant system was able to give a gentle warmth sensation (a sensation that the oral mucosa takes on a gentle warmth different from the warmth stimulus).
  • an anionic surfactant particularly sodium lauryl sulfate, which is an alkyl sulfate, is added to improve the dispersibility and foaming in the oral cavity, the oral cavity is degreased after use.
  • the sensation (unpleasant sensation of degreasing oil on the tongue and oral mucosa) was exacerbated, causing the problem of unsuitability for use.
  • the component (A) as an anionic surfactant and combining the component (B) and / or the component (C) with the component (A)
  • the feeling of degreasing in the oral mucosa is exacerbated as described above. It was possible to satisfactorily give a gentle warmth feeling immediately after the start of use, while maintaining a good feeling of use.
  • (D) a cooling sensation agent was added, in addition to the above-mentioned gentle feeling of warmth, it was possible to give a remarkable cooling sensation after use.
  • the action and effect of the present invention are specific to the above-mentioned specific surfactant system, and as shown in the comparative example described later, when the component (A) is lacking or the components (B) and (C) are lacking.
  • the onset of warmth at the start of use or the lack of degreasing in the oral cavity after use was inferior, and this effect was inferior when an inappropriate surfactant was combined and blended.
  • a polyhydric alcohol-based toothpaste containing the component (A) and the components (B) and / or (C) of the present invention and having a water content of a specific value or less.
  • the agent composition was excellent in that there was no feeling of degreasing in the oral cavity after use and that the feeling of warmth at the start of use started to rise.
  • the present invention provides the following polyhydric alcohol-based dentifrice composition.
  • A ⁇ -olefin sulfonate and A polyhydric alcohol-based dentifrice composition containing one or more selected from (B) betaine-type amphoteric surfactant and (C) nonionic surfactant, and having a water content of 2% by mass or less. ..
  • B The polyhydric alcohol-based dentifrice according to [1], wherein the betaine-type amphoteric tenside agent is selected from fatty acid amide propyl betaine having an alkyl group having 10 to 16 carbon atoms, alkyl acetate betaine and alkyl imidazolinium betaine. Composition.
  • the nonionic surfactant is selected from polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, alkyl glucoside, fatty acid polyglyceryl and polyoxyethylene polyoxypropylene copolymer according to [1] or [2].
  • Polyhydric alcohol-based dentifrice composition [4] (A) The polyhydric alcohol-based dentifrice composition according to any one of [1] to [3], which contains 0.1 to 3% by mass of the component. [5] (B) The polyhydric alcohol-based dentifrice composition according to any one of [1] to [4], wherein when the betaine-type amphoteric surfactant is contained, the content thereof is 0.1 to 3% by mass.
  • the present invention it is possible to provide a polyhydric alcohol-based dentifrice composition that gives a gentle feeling of warmth in the oral cavity immediately after use, reduces the feeling of degreasing in the oral cavity, and has a good taste.
  • the polyhydric alcohol-based dentifrice composition of the present invention does not require the addition of stimulating warming components such as capsicum and ginger, which are relatively irritating as warming agents, and provides a mild warming sensation with low irritation. It can be imparted, and by further adding (D) a cooling sensation agent, a gentle warming sensation rises at the start of use, and it is also possible to impart a unique feeling of use in which the cooling sensation gradually becomes conspicuous. Is.
  • the polyhydric alcohol-based dentifrice composition of the present invention comprises one or more selected from (A) ⁇ -olefin sulfonate, (B) betaine-type amphoteric surfactant and (C) nonionic surfactant. And the water content is 2% by mass or less. Further, in the present invention, the "defatting sensation” is an unpleasant sensation that the oil on the tongue and the oral mucosa has been deprived, and the "warm sensation” is a sensation that the oral mucosa is warm.
  • the "polyhydric alcohol-based dentifrice composition” is a dentifrice composition containing a polyhydric alcohol as a main component of a liquid medium as a base.
  • the dentifrice composition in which the main component of a general liquid medium is water is "water-based".
  • the polyhydric alcohol a polyhydric alcohol that is liquid at 25 ° C., which generates heat of hydration when in contact with water, can be used.
  • glycerin examples thereof include glycerin, polyethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, polypropylene glycol and the like having an average molecular weight of 190 to 630 (average molecular weight described in the non-medicinal product raw material standard 2006, the same applies hereinafter).
  • glycerin, polyethylene glycol having an average molecular weight of 190 to 630, and butylene glycol are preferable from the viewpoint of raising a feeling of warmth and improving the feeling of degreasing in the oral cavity.
  • polyethylene glycol having the specific average molecular weight for example, polyethylene glycol 200 (average molecular weight 190 to 210), polyethylene glycol 400 (average molecular weight 380 to 420), and polyethylene glycol 600 (average molecular weight 570 to 630) can be used.
  • polyhydric alcohols have their own bitterness, but glycerin is a polyhydric alcohol with relatively little bitterness. Therefore, from the viewpoint of reducing the bitterness derived from the liquid medium, it contains at least glycerin, and the content of glycerin is 20 to 100% (mass%, the same applies hereinafter), particularly 50 to 85%, and further 50 to 80% of the total polyhydric alcohol. Is more preferable.
  • polyethylene glycol having the specific average molecular weight contributes relatively strongly to the feeling of warmth. Therefore, from the viewpoint of the strength of the feeling of warmth, it is preferable to contain at least the polyethylene glycol, and it is more preferable that the content of the polyethylene glycol is 10% or more, particularly 15 to 30% of the whole composition. If it exceeds 30%, the bitterness derived from polyethylene glycol may affect the usability, but if it is 30% or less, a good usability can be maintained.
  • the polyhydric alcohol is a combination system of glycerin and polyethylene glycol and / or butylene glycol having an average molecular weight of 190 to 630, particularly a combination system of glycerin and polyethylene glycol having an average molecular weight of 190 to 630, and further, glycerin.
  • the content of the polyhydric alcohol is 50% or more, particularly 50 to 85% of the total polyhydric alcohol, it is particularly preferable from the viewpoint of exhibiting the effect of the present invention.
  • 13 to 95% of the whole composition is preferable, and more preferably 20 to 90. %, Especially preferably 25 to 85%, still more preferably 30 to 80%, and even 50 to 80%.
  • the polyhydric alcohol-based dentifrice composition of the present invention has a water content of 2% or less, may be less than 2%, preferably 1% or less, particularly 0, from the viewpoint of expressing a feeling of warmth. It is less than 5.5%.
  • This polyhydric alcohol-based dentifrice composition is preferably a non-water composition that does not contain water, but even if water is not added to the composition, for example, water is contained in the raw materials of other compounding components.
  • the "substantially non-aqueous composition” described here means that the amount of water in the composition is equal to or less than the above value.
  • this substantially non-aqueous composition of the polyhydric alcohol-based dentifrice composition is watered when used in the oral cavity.
  • the heat of hydration is generated by contact with, and a gentle warmth can be given to the oral cavity, and the above-mentioned warmth feeling can be given even if a stimulating warmth component such as toothpaste is not blended. Can be done.
  • the ⁇ -olefin sulfonate has an effect of improving the rise of the feeling of warmth.
  • an alkali metal salt such as sodium or potassium of ⁇ -olefin sulfonic acid having 14 to 16 carbon atoms can be used, and an ⁇ -olefin sulfonic acid salt having 14 carbon atoms is particularly preferable.
  • It is a sodium salt (generic name; sodium tetradecene sulfonate).
  • commercially available products that can be used for oral preparations can be obtained, and for example, the trade name "K Liporan PJ-400CJ" manufactured by Lion Specialty Chemicals Co., Ltd. can be used.
  • the blending amount of the (A) ⁇ -olefin sulfonate is preferably 0.1 to 3%, more preferably 0.5 to 2% of the entire composition.
  • the blending amount is 0.1% or more, the dispersibility of the pharmaceutical product in the oral cavity at the time of use is improved, and a sufficient rise in a feeling of warmth can be obtained.
  • it is 3% or less, the feeling of degreasing in the oral cavity after use is sufficiently reduced.
  • (B) betaine-type amphoteric surfactant and (C) nonionic surfactant each have an effect of reducing and improving the feeling of degreasing in the oral cavity due to the component (A), and in particular, the component (B) is , (A) also has the effect of accelerating the rise of the feeling of warmth.
  • any one of the components (B) and (C) may be blended, but it is preferable to blend the component (B) from the viewpoint of the rise of the feeling of warmth, and in particular (B). And (C) are more preferable from the viewpoint of improving the feeling of degreasing in the oral cavity and raising the feeling of warmth.
  • the betaine-type amphoteric tenside agent preferably has an alkyl group having 10 to 16 carbon atoms, and is a fatty acid amide propyl betaine having the alkyl group, an alkyl acetate betaine having the alkyl group, and an alkyl having the alkyl group.
  • Imidazolinium betaine can be used.
  • the fatty acid amide propyl betaine includes coconut oil fatty acid amide propyl betaine and the like
  • the alkyl acetate betaine includes lauryldimethylamino acetate betaine and the like
  • the alkylimidazolinium betaine includes alkylcarboxymethyl hydroxyethyl imidazolinium betaine and the like.
  • fatty acid amide propyl betaine and alkyl acetate betaine are preferable.
  • fatty acid amide propyl betaine coconut oil fatty acid amide propyl betaine are preferable.
  • the water content in the dentifrice composition is defined as 2% or less, it is preferable to use a solution or powder having a pure content (betaine pure content) of 65% or more as the betaine-type surfactant. .. These can be used alone or in combination of two or more. Moreover, a commercially available product can be used.
  • Examples of the (C) nonionic surfactant include polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, alkyl glucoside, fatty acid polyglyceryl, and polyoxyethylene polyoxypropylene (EOPO) copolymer.
  • the polyoxyethylene hydrogenated castor oil preferably has an average number of moles of ethylene oxide added of 5 to 100, particularly 5 to 60.
  • the polyoxyethylene alkyl ether has an average number of moles of ethylene oxide added of 5 to 30, and preferably an alkyl group having 12 to 18 carbon atoms. Specific examples thereof include polyoxyethylene lauryl ether and polyoxyethylene stearyl ether in which the average number of moles of ethylene oxide added is in the above range.
  • the polyoxyethylene polyoxypropylene (EOPO) copolymer preferably has an average added mole number of ethylene oxide of 20 to 210 and an average added mole number of propylene oxide of 15 to 60, and may be a block copolymer or a random copolymer.
  • polyoxyethylene hydrogenated castor oil and polyoxyethylene alkyl ether are preferable, and polyoxyethylene hydrogenated castor oil having an average addition molar number of 5 to 60 of ethylene oxide is particularly preferable. These may be used alone or in combination of two or more. Moreover, a commercially available product can be used.
  • the blending amount thereof is preferably 0.1 to 3%, more preferably 0.3 to 2% of the entire composition.
  • the blending amount is 0.1% or more, the degreasing feeling in the oral cavity is sufficiently improved, and the rise of the feeling of warmth is improved.
  • it is 3% or less, the bitterness due to itself is suppressed and a good feeling of use can be sufficiently maintained.
  • the blending amount thereof is preferably 0.05 to 2%, more preferably 0.5 to 1% of the total composition.
  • the blending amount is 0.05% or more, the feeling of degreasing in the oral cavity is sufficiently improved.
  • it is 2% or less, the bitterness due to itself is suppressed and a good feeling of use can be sufficiently maintained.
  • a surfactant other than these may be blended as long as the effect of the present invention is not impaired.
  • the optional surfactant include anionic surfactants other than the component (A), for example, an acyl amino acid salt, an acyl taurine or a salt thereof, and an alkyl sulfate such as sodium lauryl sulfate.
  • the blending amount of these arbitrary anionic surfactants is preferably 0 to 0.3% of the total composition from the viewpoint of the rise of a feeling of warmth and the absence of a feeling of degreasing in the oral cavity.
  • an alkyl sulfate such as sodium lauryl sulfate from the viewpoint of no feeling of degreasing in the oral cavity, and when it is added, the amount thereof is preferably 0.3% or less of the whole composition.
  • a cooling sensation agent when (D) a cooling sensation agent is further added, it is possible to give a moderately strong and outstanding cooling sensation to the oral cavity after use.
  • a gentle feeling of warmth rises and is sufficiently felt at the start of use, and this feeling of warmth is felt sufficiently.
  • the cool feeling stands out, which can give a unique feeling of use that changes the sensation.
  • cooling sensitizer examples include menthol derivatives such as carboxamide, alcohols, esters, and menthol derivatives having an ether structure. Specifically, N-ethyl-p-mentane-3-carboxamide, ethyl-3- (p-mentane-carboxamide) acetate, mentyl lactate, mentyl monosuccinate, isopregol, mentonglycerol ketal, N- (4-cyano).
  • Methylphenyl) -p-menthanecarboxamide 2-isopropyl-5-methyl-N- (2- (pyridine-4-yl) ethyl) cyclohexanecarboxamide, 3-l-mentoxypropane-1,2-diol and the like.
  • N-ethyl-p-menthane-3-carboxamide and N- (4-cyanomethylphenyl) -p-menthanecarboxamide are preferable from the viewpoint of imparting a cooling sensation.
  • These may be used alone or in combination of two or more.
  • a commercially available product can be used.
  • the blending amount of the component (D) is preferably 0.0001 to 0.3%, more preferably 0.001 to 0.2%, still more preferably 0.01 to 0.1% of the entire composition. Within this range, a feeling of coolness can be sufficiently obtained, and irritation and bitterness due to itself can be sufficiently suppressed, and a feeling of use can be sufficiently maintained.
  • the polyhydric alcohol-based dentifrice composition of the present invention can be formed into a paste-like or gel-like shape, and can be particularly prepared as a dentifrice or a gel dentifrice. Further, in addition to the above-mentioned components, other known components according to the dosage form and the like can be blended as needed, and these can be used as long as the effects of the present invention are not impaired. For example, abrasives, binders, oily ingredients, flavors, sweeteners, preservatives, colorants, active ingredients and the like can be mentioned.
  • abrasive examples include silica-based abrasives such as precipitated silica, silica gel, aluminosilicate, and zirconosilicate, calcium carbonate, calcium phosphate, aluminum silicate, and aluminum hydroxide.
  • the blending amount of the abrasive is usually 0 to 70%, particularly 2 to 30% of the whole composition.
  • an organic binder such as a water-soluble polymer or an inorganic binder
  • examples of the organic binder include cellulose derivatives such as sodium carboxymethyl cellulose, gums such as xanthan gum, tragant gum, karaya gum and arabia gum, carboxyvinyl polymers, polyvinyl alcohol, crosslinked sodium polyacrylate, carrageenan, sodium alginate and polyvinylpyrrolidone. Be done.
  • the inorganic binder include thickening silica such as precipitate silica, igneable silica, gelling silica and gelling aluminum silica, and clay minerals such as bee gum, laponite and bentonite.
  • the blending amount of the binder is usually 0.1 to 10%, particularly 0.2 to 5% of the whole composition.
  • the binder is preferably an organic binder, particularly a carboxyvinyl polymer, and the blending amount thereof is preferably 0.1 to 3%, particularly 0.3 to 2% of the entire composition.
  • Oily components include hydrocarbons (squalane, liquid paraffin, vaseline, microcrystallin wax, etc.), higher alcohols with 8 to 22 carbon atoms (lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, isostearyl alcohol, etc.), carbon. Examples thereof include higher fatty acids (lauric acid, myristic acid, oleic acid, isostearic acid, etc.), vegetable oils (olive oil, castor oil, palm oil, etc.), fatty acid esters (isopropyl myristate, etc.) having a number of 8 to 22.
  • hydrocarbons squalane, liquid paraffin, vaseline, microcrystallin wax, etc.
  • higher alcohols with 8 to 22 carbon atoms laauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, isostearyl alcohol, etc.
  • carbon examples thereof include higher fatty acids (lauric acid, myristic acid, oleic acid, is
  • the fragrances are peppermint oil, sparemint oil, anis oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamon oil, coriander oil, mandarin oil, lime.
  • Oil lavender oil, rosemary oil, laurel oil, camomill oil, caraway oil, majorum oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute peppermint , Absolute rose, orange flower and other natural fragrances, and processed fragrances (pre-reservoir cut, rear-reservoir cut, distilling, liquid extraction, essence, powder fragrance, etc.) and menthol.
  • Grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor and other compounded fragrances, and known fragrance materials used in dentifrice compositions can be used. It is preferable to use 0.000001 to 1% of the above fragrance material in the composition, and 0.1 to 2.0% of the fragrance for perfume using the above fragrance material is used in the composition. good.
  • sweetener examples include saccharin sodium, stebioside, stevia extract, neohesperidyl dihydrochalcone, glycyrrhizin, perillartine, p-methoxycinnamic aldehyde, aspartame, xylitol and the like.
  • preservative examples include paraoxybenzoic acid esters such as butylparaben, propylparaben and ethylparaben, and sodium benzoate.
  • colorant examples include Blue No. 1, Blue No. 4, Green No. 3 and the like.
  • the active ingredient is a fluorine-containing compound such as sodium monofluorophosphate and sodium fluoride; a water-soluble phosphoric acid compound such as a potassium salt of orthophosphoric acid and a sodium salt; Enzymes such as stranase, mutanase, protease; copper compounds such as copper gluconate; chelate phosphate compounds such as glycerophosphate; cationic bactericides such as cetylpyridium chloride, benzethonium chloride, benzalkonium chloride; isopropylmethylphenol Non-ionic bactericides such as; Touki soft extract; Oubaku extract; Extracts such as chamomile, chowji, rosemary, ginger, benibana, tranexamic acid, hinokithiol, sodium chloride, dl- ⁇ -tocopherol acetate, coenzyme Q10, dihydro Cholesterol, ⁇ -bisabolol, chlorhexidine
  • Examples, comparative examples Polyhydric alcohol-based dentifrice compositions (dentifrices) having the compositions shown in Tables 1 to 5 were prepared by a conventional method, and the evaluations shown in each table were performed by the following methods. The results are also shown in the table. In the table, the numerical value indicating the blending amount of each component is the pure content.
  • the dentifrice compositions shown in Tables 1 to 5 are substantially non-aqueous compositions having a water content of 2% or less.
  • ⁇ Evaluation method> Evaluation method for the lack of degreasing in the oral cavity after use
  • the lack of degreasing feeling was judged on a 5-point scale according to the scoring criteria shown below.
  • the average score of 10 testers was calculated, evaluated according to the evaluation criteria shown below, and shown in the table with ⁇ , ⁇ , ⁇ , ⁇ , and ⁇ .
  • the "defatting sensation” is an unpleasant sensation that the oil on the tongue and oral mucosa has been deprived.
  • the control dentifrice composition is a water-based dentifrice composition (dentifrice) having the same composition except that water is added instead of the concentrated glycerin of each composition.
  • the average score of 10 testers was calculated, evaluated according to the evaluation criteria shown below, and indicated by ⁇ , ⁇ , ⁇ , and ⁇ in the table.
  • the "cool feeling" indicates an appropriate cool feeling that is felt after gargle the mouth.
  • (A) component Sodium tetradecene sulfonate (manufactured by Lion Specialty Chemicals Co., Ltd., trade name: K Liporan PJ-400CJ)
  • Betaine lauryldimethylaminoacetate manufactured by Sigma-Aldrich, trade name: (Lauryldimethyllaminio) acetate, betaine pure content ⁇ 95%)
  • C) component Polyoxyethylene (20) hardened castor oil (manufactured by Nippon Surfactant Industry Co., Ltd., trade name:
  • a polyhydric alcohol-based dentifrice composition having a water content of a specific value or less is blended with a component (A) and a component (B) and / or a component (C), and further (D) a cooling sensitizer.
  • the cooling sensation after dentifrice was stronger than that of the water-based dentifrice composition (control dentifrice composition), and the result was that it was noticeably felt.
  • a gentle feeling of warmth was felt at the beginning of brushing, and the feeling of warmth gradually changed to a feeling of coolness, and a unique feeling of use was recognized that the feeling of coolness became conspicuous after use. ..
  • each dentifrice composition was prepared in the same manner using the same raw materials as above.
  • the numerical value indicating the blending amount of each component is the pure amount.

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  • Animal Behavior & Ethology (AREA)
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Abstract

L'invention concerne une composition de dentifrice à base d'alcool polyhydrique offrant une légère sensation réelle de chaleur immédiatement après avoir été utilisée dans la bouche et présentant une sensation d'utilisation agréable par réduction de la sensation de délipidation dans la bouche.　La présente composition de dentifrice à base d'alcool polyhydrique contient un ou plusieurs éléments choisis parmi (A) un sulfonate d'α-oléfine, (B) un tensioactif amphotère de type bétaïne, et (C) un tensioactif non ionique, et présente une teneur en eau de 2 % en masse ou moins. La composition de dentifrice à base d'alcool polyhydrique contient en outre une quantité spécifique de (D) un agent de sensation de fraîcheur.
PCT/JP2020/036035 2020-09-24 2020-09-24 Composition de dentifrice à base d'alcool polyhydrique WO2022064598A1 (fr)

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JP2022551493A JPWO2022064598A1 (fr) 2020-09-24 2020-09-24
PCT/JP2020/036035 WO2022064598A1 (fr) 2020-09-24 2020-09-24 Composition de dentifrice à base d'alcool polyhydrique
CN202080105495.8A CN116249512A (zh) 2020-09-24 2020-09-24 多元醇系洁齿剂组合物

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JP2014521707A (ja) * 2011-08-09 2014-08-28 グラクソ グループ リミテッド 新規組成物
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