CN116806140A - 口腔用组合物 - Google Patents
口腔用组合物 Download PDFInfo
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- CN116806140A CN116806140A CN202180087598.0A CN202180087598A CN116806140A CN 116806140 A CN116806140 A CN 116806140A CN 202180087598 A CN202180087598 A CN 202180087598A CN 116806140 A CN116806140 A CN 116806140A
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- oral composition
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- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 110
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 52
- 239000003899 bactericide agent Substances 0.000 claims abstract description 52
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- GWRCTWAPTXBPHW-UHFFFAOYSA-N N-[(Ethoxycarbonyl)methyl)-p-menthane-3-carboxamide Chemical compound CCOC(=O)CNC(=O)C1CC(C)CCC1C(C)C GWRCTWAPTXBPHW-UHFFFAOYSA-N 0.000 claims abstract description 5
- -1 acyl sarcosinate Chemical compound 0.000 claims description 63
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- 239000000194 fatty acid Substances 0.000 claims description 27
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- 229930195729 fatty acid Natural products 0.000 claims description 26
- 210000000214 mouth Anatomy 0.000 claims description 21
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 20
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 20
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- 239000000341 volatile oil Substances 0.000 claims description 14
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- 125000002091 cationic group Chemical group 0.000 claims description 8
- 125000000129 anionic group Chemical group 0.000 claims description 7
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- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims description 6
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- 239000011248 coating agent Substances 0.000 claims description 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 4
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims description 3
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- 125000004432 carbon atom Chemical group C* 0.000 description 9
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- 125000002252 acyl group Chemical group 0.000 description 7
- 125000000217 alkyl group Chemical group 0.000 description 7
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- 239000000377 silicon dioxide Substances 0.000 description 7
- 239000000606 toothpaste Substances 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 6
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- 229940034610 toothpaste Drugs 0.000 description 6
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 5
- 239000002202 Polyethylene glycol Substances 0.000 description 5
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 5
- 229940024606 amino acid Drugs 0.000 description 5
- 235000001014 amino acid Nutrition 0.000 description 5
- 239000002280 amphoteric surfactant Substances 0.000 description 5
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- 159000000000 sodium salts Chemical class 0.000 description 5
- 150000005846 sugar alcohols Chemical class 0.000 description 5
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- HFDVRLIODXPAHB-UHFFFAOYSA-N 1-tetradecene Chemical compound CCCCCCCCCCCCC=C HFDVRLIODXPAHB-UHFFFAOYSA-N 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- FFDGPVCHZBVARC-UHFFFAOYSA-N N,N-dimethylglycine Chemical compound CN(C)CC(O)=O FFDGPVCHZBVARC-UHFFFAOYSA-N 0.000 description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 4
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 4
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 4
- 235000010449 maltitol Nutrition 0.000 description 4
- 239000000845 maltitol Substances 0.000 description 4
- 229940035436 maltitol Drugs 0.000 description 4
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
- 230000002335 preservative effect Effects 0.000 description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 4
- 229940104261 taurate Drugs 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 108010011485 Aspartame Proteins 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- VUNOFAIHSALQQH-UHFFFAOYSA-N Ethyl menthane carboxamide Chemical compound CCNC(=O)C1CC(C)CCC1C(C)C VUNOFAIHSALQQH-UHFFFAOYSA-N 0.000 description 3
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 150000008051 alkyl sulfates Chemical class 0.000 description 3
- 150000003863 ammonium salts Chemical class 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 3
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 3
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000003086 colorant Substances 0.000 description 3
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- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 3
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 3
- 238000005498 polishing Methods 0.000 description 3
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
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- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 3
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 3
- 239000004711 α-olefin Substances 0.000 description 3
- XHXUANMFYXWVNG-ADEWGFFLSA-N (-)-Menthyl acetate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(C)=O XHXUANMFYXWVNG-ADEWGFFLSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 2
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Abstract
本发明的课题在于提供一种口腔用组合物,其在使用开始时具有清凉感,能够在从使用开始到使用后经过一定时间后抑制来自杀菌剂的苦味,进而能够使抑制作用持续。一种口腔用组合物,其含有(A)杀菌剂,以及(B)选自N‑(乙氧羰基甲基)‑对薄荷烷‑3‑甲酰胺和N‑(2‑羟基‑2‑苯基乙基)‑2‑异丙基‑5,5‑二甲基环己烷‑1‑甲酰胺中的1种以上。
Description
技术领域
本发明涉及一种口腔用组合物。
背景技术
洁齿剂等口腔用组合物所包含的杀菌剂是对降低口腔内的病原性细菌数、抑制口臭、预防龋齿、预防牙周病等有效果的重要成分。然而,杀菌剂具有杀菌剂特有的苦味。由于该苦味,即使配合薄荷醇等清凉剂,在开始使用口腔用组合物时也不会感觉到清凉感,从使用开始到使用后经过一定时间后苦味持续,因此使用感明显受损。因此,迄今为止也进行了掩蔽来自杀菌剂的苦味的各种研究。
专利文献1涉及含有杀菌剂(异丙基甲基苯酚)、聚乙烯吡咯烷酮、香料成分(选自3-辛醇、3-辛基乙酸酯和3-辛酮中的至少1种)和表面活性剂的口腔组合物。专利文献1公开了通过以特定的比例含有聚乙烯吡咯烷酮,能够掩蔽刷牙中来自杀菌剂的异味。专利文献2涉及包含对预防牙周病有效的成分(葡聚糖酶、氨甲环酸和异丙基甲基苯酚)、烷基硫酸盐和香料成分(薄荷醇、茴香脑和丁香酚和/或百里香油)的洁齿剂组合物。专利文献2公开了通过以特定的比例含有香料成分,能够掩蔽刷牙后的复合异味。专利文献3涉及含有杀菌剂(阳离子型杀菌剂)、保湿·抗菌剂(烷二醇)和冷感剂(3-1-甲氧基丙烷-1,2-二醇和/或N-取代-对薄荷烷-3-甲酰胺)的口腔用组合物。专利文献3公开了通过并用保湿·抗菌剂和冷感剂,能够掩蔽在口腔内应用口腔组合物之后不久来自杀菌剂的异味。专利文献4涉及含有杀菌剂、香料(日本薄荷油和N-(2-(2-吡啶基)乙基)-2-异丙基-5-甲基环己烷甲酰胺)的口腔用组合物。专利文献4公开了通过并用薄荷油和N-(2-(2-吡啶基)乙基)-2-异丙基-5-甲基环己烷甲酰胺,能够掩蔽在漱口之后来自杀菌剂的苦味。
[现有技术文献]
[专利文献]
专利文献1:日本专利第5493732号公报
专利文献2:日本特开2019-167297号公报
专利文献3:日本专利第6740901号公报
专利文献4:日本特开2018-203645号公报
发明内容
[发明所要解决的课题]
在口腔用组合物中,如果不仅苦味被抑制,而且能够持续体会到使用开始时也能感觉到由清凉剂引起的清凉感那样的适当的使用感,则导致口腔用组合物的持续利用,结果也能够期待口腔内的杀菌效果的提高。但是,专利文献1~4并没有从使用开始时的清凉感和苦味的抑制效果的持续性的观点出发来公开口腔用组合物。
本发明是鉴于上述情况而完成的,其课题在于提供一种口腔用组合物,其在使用开始时具有清凉感,从使用开始到使用后(例如,在洁齿剂的情况下,从刷牙开始到刷牙后)经过一定时间后能够抑制来自杀菌剂的苦味。
[用于解决课题的手段]
即,本发明提供以下〔1〕~〔12〕。
〔1〕一种口腔用组合物,其特征在于,所述口腔用组合物含有(A)杀菌剂和(B)选自由N-(乙氧羰基甲基)-对薄荷烷-3-甲酰胺(日文原文:エチル-3-(p-メンタン-3-カルボキサミド)アセテート)和N-(2-羟基-2-苯基乙基)-2-异丙基-5,5-二甲基环己烷-1-甲酰胺组成的组中的1种以上。
〔2〕根据〔1〕记载的口腔用组合物,其中,(A)成分为选自由阳离子型杀菌剂、非离子型杀菌剂及阴离子型杀菌剂组成的组中的1种以上的杀菌剂。
〔3〕根据〔1〕或〔2〕记载的口腔用组合物,其中,(A)成分为选自由季铵盐、双胍系杀菌剂、酚系杀菌剂、桉树脑和酰基肌氨酸盐组成的组中的1种以上的杀菌剂。
〔4〕根据〔1〕~〔3〕中任一项记载的口腔用组合物,其中,相对于口腔用组合物100质量%,(A)成分的含量为0.001质量%~0.5质量%。
〔5〕如〔1〕~〔4〕中任一项记载的口腔用组合物,其中,相对于口腔用组合物100质量%,(B)成分的含量为0.00001质量%~0.1质量%。
〔6〕根据〔1〕~〔5〕中任一项记载的口腔用组合物,其中,所述口腔用组合物还含有(C)非离子表面活性剂。
〔7〕根据〔6〕记载的口腔用组合物,其中,(C)成分为选自由聚氧乙烯氢化蓖麻油、聚氧乙烯烷基醚、聚甘油脂肪酸酯和聚氧乙烯聚氧丙烯共聚物组成的组中的1种以上的非离子表面活性剂。
〔8〕根据〔6〕或〔7〕记载的口腔用组合物,其中,相对于口腔用组合物100质量%,(C)成分的含量为0.1质量%~2质量%。
〔9〕根据〔1〕~〔8〕中任一项记载的口腔用组合物,其中,所述口腔用组合物还含有(D)清凉剂。
〔10〕根据〔9〕记载的口腔用组合物,其中,(D)成分为薄荷醇和香芹酮中的任一者或两者,或者为包含薄荷醇和香芹酮中的任一者或两者的精油。
〔11〕根据〔9〕或〔10〕记载的口腔用组合物,其中,相对于口腔用组合物100质量%,(D)成分的含量以薄荷醇和香芹酮中的任一者或两者的含量计,为0.001质量%~1.5质量%。
〔12〕根据〔1〕~〔11〕中任一项记载的口腔用组合物,其中,所述口腔用组合物为洁齿剂、漱口剂、喷雾剂、涂布剂、贴附剂或口腔内溶解剂。
[发明效果]
根据本发明,能够提供一种口腔用组合物,其在使用开始时具有清凉感,从使用开始到使用后经后一定时间后,能够抑制来自杀菌剂的苦味。
具体实施方式
以下,对本发明详细进行说明。
本发明的口腔用组合物含有下述(A)成分和(B)成分,优选进一步含有(C)成分和(D)成分中的任一者或两者。应予说明,在本说明书中,各成分的含量以制造组合物时的各成分的投入量为基准。
[(A)成分]
(A)成分为杀菌剂。通过使口腔用组合物含有(A)成分,能够发挥杀菌效果。
作为(A)成分,例如可举出阳离子型杀菌剂、非离子型杀菌剂及阴离子型杀菌剂。(A)成分优选为选自阳离子型杀菌剂、非离子型杀菌剂及阴离子型杀菌剂中的1种以上的杀菌剂。作为阳离子型杀菌剂,优选季铵盐、双胍系杀菌剂,例如可举出烷基吡啶鎓盐、苄基长链烷基短链二烷基铵盐、长链烷基短链三烷基铵盐等季铵盐;氯己定盐等双胍系杀菌剂。作为(A)成分,更具体而言,例如可举出苄索氯铵、苯扎氯铵、地喹氯铵(DequaliniumChloride)、氯化十六烷基吡啶鎓、硬脂基二甲基苄基氯化铵、月桂基三甲基氯化铵、肉豆蔻基三甲基氯化铵、鲸蜡基三甲基氯化铵、硬脂基三甲基氯化铵、氯己定(chlorhexidine)、盐酸氯己定、葡萄糖酸氯己定、乙酸氯己定。其中,特别优选苄索氯铵、苯扎氯铵和氯化十六烷基吡啶鎓。作为非离子型杀菌剂,优选酚系杀菌剂、桉树脑,例如可举出异丙基甲基苯酚、扁柏酚、三氯生、百里酚、百里香油、1,8-桉树脑、桉树油。其中,作为非离子型杀菌剂,优选异丙基甲基苯酚、扁柏酚。作为阴离子型杀菌剂,优选具有酰基(例如,碳原子数为10~18的酰基)的酰基肌氨酸盐(例如,钠盐等碱金属盐),其中优选月桂酰肌氨酸钠。因此,(A)成分优选为选自季铵盐、双胍系杀菌剂、酚系杀菌剂、桉树脑和酰基肌氨酸盐中的1种以上的杀菌剂。这些可以单独使用1种,也可以组合使用2种以上。
从不强烈表现来自杀菌剂的苦味(以下,简称为苦味)而发挥杀菌效果的观点出发,相对于口腔用组合物整体(100质量%),(A)成分的含量的下限优选为0.001质量%以上,更优选为0.005质量%以上。由此,能够得到良好的杀菌效果。上限优选为0.5质量%以下。由此,能够抑制苦味的表现。因此,(A)成分的含量优选为0.001质量%~0.5质量%,更优选为0.005质量%~0.5质量%。在上述范围内,在(A)成分含有阳离子型杀菌剂的情况下,相对于口腔用组合物整体(100质量%),阳离子型杀菌剂的含量优选为0.001质量%~0.5质量%,更优选为0.005质量%~0.2质量%。在(A)成分含有非离子型杀菌剂的情况下,相对于口腔用组合物整体(100质量%),非离子型杀菌剂的含量优选为0.005质量%~0.2质量%。在(A)成分含有阴离子型杀菌剂的情况下,相对于口腔用组合物整体(100质量%),阴离子型杀菌剂的含量优选为0.05质量%~0.5质量%。
[(B)成分]
(B)成分为选自N-(乙氧羰基甲基)-对薄荷烷-3-甲酰胺和N-(2-羟基-2-苯基乙基)-2-异丙基-5,5-二甲基环己烷-1-甲酰胺中的1种以上。通过使口腔用组合物含有(B)成分,即使口腔用组合物中含有杀菌剂,使用时也能感觉到清凉感,能够在从使用开始到使用后经过一定时间后持续抑制苦味。在本说明书中,“清凉感”是指对口腔用组合物良好发挥作用的感觉,不仅是指清凉感,也指包括清爽感、舒适感的复合的感觉。
(B)成分可以为单独1种也可以组合2种以上,优选含有N-(2-羟基-2-苯基乙基)-2-异丙基-5,5-二甲基环己烷-1-甲酰胺。由此,能够在从使用开始到使用后经过一定时间后进一步提高苦味的抑制持续效果。
相对于口腔用组合物整体(100质量%),(B)成分的含量的下限优选为0.00001质量%以上,更优选为0.00005质量%以上。由此,能够在从使用开始到使用后经过一定时间后发挥苦味的抑制持续效果。相对于口腔用组合物整体(100质量%),(B)成分的含量的上限优选为0.1质量%以下,更优选为0.01质量%以下,特别优选为0.005质量%以下。由此,能够抑制对口腔内的刺激表现、香料(冷感剂以外的香料)的香味显现性降低。即,相对于口腔用组合物整体(100质量%),(B)成分的含量优选为0.00001质量%~0.1质量%,更优选为0.00005质量%~0.005质量%。
[(C)成分]
(C)成分为非离子表面活性剂。通过使口腔用组合物含有(C)成分,能够抑制使用开始时的清凉感的降低,从使用开始到使用后经过一定时间后赋予苦味的抑制持续效果。
作为(C)成分,例如可举出聚氧乙烯烷基醚、聚氧乙烯氢化蓖麻油、山梨糖醇酐脂肪酸酯、聚氧乙烯山梨糖醇酐脂肪酸酯(例如,聚氧乙烯山梨糖醇酐单硬脂酸酯)、烷醇酰胺、聚氧乙烯脂肪酸酯、聚氧乙烯烯基醚、聚甘油脂肪酸酯、蔗糖脂肪酸酯(例如,麦芽糖脂肪酸酯)、糖醇脂肪酸酯(例如,麦芽糖醇脂肪酸酯、乳糖醇脂肪酸酯)、脂肪酸二乙醇酰胺(例如,月桂酸单或二乙醇酰胺)、聚氧乙烯聚氧丙烯共聚物、聚氧乙烯聚氧丙烯脂肪酸酯。聚氧乙烯烷基醚的烷基链的碳原子数通常为14~18,环氧乙烷平均加成摩尔数通常为5摩尔~30摩尔。聚氧乙烯氢化蓖麻油的环氧乙烷平均加成摩尔数通常为20摩尔~100摩尔,优选为20摩尔~60摩尔。山梨糖醇酐脂肪酸酯的脂肪酸的碳原子数通常为12~18。聚氧乙烯山梨糖醇酐脂肪酸酯的脂肪酸的碳原子数通常为16~18,环氧乙烷平均加成摩尔数通常为10摩尔~40摩尔。烷醇酰胺的烷基链的碳原子数通常为12~14。作为非离子表面活性剂,优选为选自聚氧乙烯氢化蓖麻油、聚氧乙烯烷基醚、聚甘油脂肪酸酯和聚氧乙烯聚氧丙烯共聚物中的1种以上的非离子表面活性剂。这些可以单独使用1种,也可以组合使用2种以上。
相对于口腔用组合物整体(100质量%),(C)成分的含量的下限优选为0.1质量%以上,更优选为0.3质量%以上。由此,能够良好表现出苦味的抑制效果。相对于口腔用组合物整体(100质量%),上限优选为2质量%以下,更优选为1质量%以下,特别优选为0.8质量%以下。由此,能够抑制使用开始时的清凉感的降低,从使用开始到使用后经过一定时间后赋予苦味的抑制持续效果。因此,相对于口腔用组合物整体(100质量%),(C)成分的含量优选为0.1质量%~2质量%,更优选为0.3质量%~1质量%,进一步优选为0.3质量%~0.8质量%。
[(D)成分]
(D)成分为清凉剂。通过使口腔用组合物含有(D)成分,能够赋予清凉感,能够改善使用时的使用感。
作为(D)成分即清凉剂的例子,具体可举出薄荷醇和香芹酮。薄荷醇和香芹酮均能够作为化合物配合。另外,也能够使用包含薄荷醇和香芹酮中的任一者或两者的精油。作为精油,例如可举出薄荷油、日本薄荷油和留兰香油。(D)成分可以为单独1种,也可以组合2种以上。其中,从更能够赋予清爽感的观点出发,优选包含薄荷醇和含薄荷醇的精油中的任一者或两者。
相对于口腔用组合物整体(100质量%),以薄荷醇和香芹酮中的任一者或两者的含量(在使用精油的情况下,也包含精油中的薄荷醇、香芹酮的量)计,(D)成分的含量优选为0.001质量%以上,更优选为0.01质量%以上。上限通常为1.5质量%以下,优选为1.2质量%以下,更优选为0.8质量%以下。因此,优选为0.001质量%~1.5质量%,更优选为0.001质量%~1.2量,进一步优选为0.01质量%~0.8质量%。
[任意成分]
本实施方式的口腔用组合物在不损害本发明的效果的范围内,除了已经说明的(A)~(D)成分以外,也可以含有任意成分。
作为任意成分,例如可举出研磨剂、药用成分、(C)成分以外的表面活性剂、湿润剂、粘结剂、甜味剂、防腐剂、pH调节剂、溶剂、油性成分、着色剂(色素)、(D)成分以外的香料。以下,具体进行说明。
-研磨剂-
研磨剂可以是无机研磨剂和有机研磨剂中的任一种。作为无机研磨剂,例如可举出沉淀二氧化硅、硅酸铝、硅酸锆、结晶性硅酸锆、钛结合性二氧化硅等研磨性二氧化硅;磷酸氢钙·2水合盐或非水合物、磷酸二氢钙、磷酸三钙、焦磷酸钙等磷酸钙系化合物;碳酸钙等碳酸钙系研磨剂;氢氧化钙、硫酸钙等碳酸/磷酸以外的钙系研磨剂;氧化铝(aluminiumoxide)、氢氧化铝、氧化铝(alumina)等铝系材料;无水硅酸(日文原文:無水ケイ酸)、沸石、硅酸锆等硅酸系材料;碳酸镁、磷酸三镁等镁系材料;羟基磷灰石、氟磷灰石、钙缺损磷灰石等磷灰石系材料;二氧化钛、云母钛、氧化钛等钛系材料;膨润土等矿物。作为有机研磨剂,例如可举出聚甲基丙烯酸甲酯、合成树脂系研磨剂。其中,优选二氧化硅系研磨剂。
相对于口腔用组合物整体(100质量%),研磨剂的含量通常为70质量%以下,优选为50质量%以下,更优选为8质量%~50质量%。
-药用成分-
作为药用成分,例如可举出葡聚糖酶、变聚糖酶、淀粉酶、蛋白酶、LeTech酶(日文原文:リテックエンザイム)等酶;氟化钠、单氟磷酸钠、氟化锡等氟化物;ε-氨基己酸、尿囊素、氨甲环酸、甘草酸盐(例如,甘草酸二钾盐)、甘草次酸、甘草次酸衍生物(例如,甘草次酸硬脂酯)、尿囊素氯羟基铝、薁、二氢胆固醇等抗炎剂;锌盐、铜盐、锡盐等金属盐;缩聚磷酸盐、乙烷羟基二膦酸酯等牙石预防剂;维生素E(例如,乙酸生育酚)等血流促进剂;硝酸钾、乳酸铝、氯化锶等知觉过敏抑制剂;羟乙基纤维素二甲基二烯丙基氯化铵等涂布剂;维生素C(例如,抗坏血酸或其盐)、氯化溶菌酶、氯化钠等收敛剂;叶绿素铜、葡萄糖酸铜等水溶性铜化合物;牙结石预防剂;丙氨酸、甘氨酸、脯氨酸等氨基酸类;百里香、黄芩、丁香、北美金缕梅等植物提取物;海狗肽;聚乙烯吡咯烷酮等。它们可以单独使用1种,也可以组合使用2种以上。上述药效成分的含量能够根据常规方法适当设定有效量。
-表面活性剂-
任意的表面活性剂是(C)成分以外的表面活性剂,是阴离子性表面活性剂和两性表面活性剂。
作为阴离子性表面活性剂,例如可举出烷基硫酸盐、酰基氨基酸盐、酰基牛磺酸盐、α-烯烃磺酸盐、氢化椰油脂肪酸单甘油酯单硫酸盐、月桂基磺基乙酸盐。烷基、酰基可以是直链和支链中的任意一种,可以是饱和和不饱和中的任一种,其碳原子数通常为10~20,优选为12~18,更优选为12~14。盐能够从药理学上允许的盐中选择。作为药理学上允许的盐,例如可举出碱加成盐和氨基酸盐。作为其具体例,可举出钠盐、钾盐、钙盐、镁盐、铵盐等无机碱盐;三乙基铵盐、三乙醇铵盐、吡啶鎓盐、二异丙基铵盐等有机碱盐;精氨酸盐等碱性氨基酸盐。其中,优选无机碱盐,更优选碱金属盐(例如,钠盐、钾盐)或铵盐,进一步优选钠盐。
作为烷基硫酸盐,例如可举出月桂基硫酸盐(月桂基硫酸钠)和肉豆蔻酰基硫酸盐。作为酰基氨基酸盐,例如可举出月桂酰基谷氨酸盐、肉豆蔻酰基谷氨酸盐、棕榈酰基谷氨酸盐等酰基谷氨酸盐;N-月桂酰基-N-甲基甘氨酸盐、椰油酰基甘氨酸盐等酰基甘氨酸盐;N-月桂酰基-β-丙氨酸盐、N-肉豆蔻基-β-丙氨酸盐、N-椰油酰基-β-丙氨酸盐、N-月桂酰基-N-甲基-β-丙氨酸盐、N-肉豆蔻酰基-N-甲基-β-丙氨酸盐、N-甲基-N-酰基丙氨酸盐等酰基丙氨酸盐;月桂酰基天冬氨酸盐等酰基天冬氨酸盐。作为酰基牛磺酸盐,例如可举出月桂酰基甲基牛磺酸盐、N-甲基-N-酰基牛磺酸盐、N-椰油酰基甲基牛磺酸盐。作为α-烯烃磺酸盐,例如可举出十四烯磺酸盐等碳原子数为12~18的α-烯烃磺酸盐。作为阴离子性表面活性剂的其它例子,例如可举出氢化椰油脂肪酸单甘油酯单硫酸钠、月桂醇磺基乙酸酯钠。
从起泡、泡质的良好性的观点出发,阴离子性表面活性剂优选含有磺酸基,更优选月桂基硫酸盐和十四烯磺酸盐。阴离子性表面活性剂的含量优选为口腔用组合物整体的0.1质量%~2.5质量%,更优选为0.6质量%~2.5质量%,进一步优选为1质量%~2.5质量%。
作为两性表面活性剂,例如可举出烷基二甲基氨基乙酸甜菜碱(例如,月桂基二甲基氨基乙酸甜菜碱)、脂肪酸酰胺丙基二甲基氨基乙酸甜菜碱(例如,椰油酰胺丙基甜菜碱)等甜菜碱型两性表面活性剂;N-脂肪酸酰基-N-羧甲基-N-羟基乙基乙二胺盐(例如,N-椰油脂肪酸酰基-N-羧甲基-N-羟乙基咪唑啉甜菜碱)、椰油脂肪酸咪唑啉甜菜碱、2-烷基-N-羧甲基-N-羟乙基咪唑啉甜菜碱等咪唑啉型两性表面活性剂;月桂基二甲基氨基乙酸甜菜碱等烷基甜菜碱。作为阳离子性表面活性剂,例如可举出烷基铵盐、烷基苄基铵盐。两性表面活性剂的含量优选为口腔用组合物整体的0.1质量%~2质量%,更优选为0.2质量%~1.5质量%,进一步优选为0.3质量%~1质量%。
相对于口腔用组合物整体(100质量%),表面活性剂(除(C)成分以外)的含量优选为3质量%以下,更优选为2质量%以下,优选为0.1质量%~3质量%,特别优选为0.3质量%~2质量%。
-湿润剂-
通过使口腔用组合物含有湿润剂,能够进一步提高使用时的使用感。
作为湿润剂,例如可举出糖醇、糖醇以外的多元醇。作为糖醇,例如可举出山梨糖醇(山梨醇)、赤藓糖醇、麦芽糖醇、乳糖醇、木糖醇。作为糖醇以外的多元醇,可举出甘油;乙二醇、丙二醇、二丙二醇、丁二醇、聚乙二醇(PEG)等二醇;还原淀粉糖化物。作为聚乙二醇,例如优选平均分子量为150~6000的聚乙二醇,优选平均分子量为190~630的聚乙二醇(PEG200、PEG300、PEG400、PEG600)。平均分子量是准医药品原料规格2006记载的平均分子量。
相对于口腔用组合物整体(100质量%),湿润剂的含量通常为40质量%以下,优选为1质量%~30质量%。
-粘结剂-
通过使口腔用组合物含有粘结剂,能够使口腔用组合物的粘度最优化,进一步提高保形性和使用感。
作为粘结剂,可举出以往公知的任意适当的有机粘结剂,例如多糖类、纤维素系粘结剂(例如,羧甲基纤维素(CMC)、羟乙基纤维素、羟丙基纤维素、羟丙基甲基纤维素、甲基纤维素、阳离子化纤维素等)、其他多糖系增粘剂(例如,黄原胶、瓜尔豆胶、结冷胶、黄蓍胶、刺梧桐胶、阿拉伯胶、刺槐豆胶、卡拉胶、海藻酸钠)、合成水溶性高分子(例如,聚丙烯酸钠、羧基乙烯基聚合物、聚乙烯吡咯烷酮、聚乙烯醇、海藻酸丙二醇酯)。进而,也能够使口腔用组合物含有增稠性二氧化硅、硅酸铝等无机粘结剂。
相对于口腔用组合物整体(100质量%),有机粘结剂的含量优选为0质量%~3质量%,更优选为0.1质量%~2质量%。无机粘结剂的含量优选为0质量%~10质量%,更优选为1质量%~8质量%。
-甜味剂-
通过使口腔用组合物含有甜味剂,能够进一步提高使用感。作为甜味剂,例如可举出木糖醇、赤藓糖醇、麦芽糖醇、糖精、糖精钠、阿斯巴甜、甜菊糖、甜叶菊提取物、对甲氧基肉桂醛、新橙皮苷二氢查耳酮、紫苏葶、甘草酸苷(glycyrrhizin)、甜味蛋白(Thaumatin)、天冬氨酰苯基丙氨酸甲酯(aspartyl-phenylalanine methyl ester)。作为甜味剂,可以单独使用1种上述例示的甜味剂,也可以组合使用2种以上。
-防腐剂-
通过使口腔用组合物含有防腐剂,能够确保制剂的防腐力。
作为防腐剂,例如可举出对羟基苯甲酸酯(例如,对羟基苯甲酸甲酯、对羟基苯甲酸乙酯、对羟基苯甲酸丁酯)、苯甲酸钠等。防腐剂可以单独使用1种,也可以组合使用2种以上。
-pH调节剂-
通过使口腔用组合物含有pH调节剂,能够确保制剂的pH稳定性。
作为pH调节剂,例如可举出邻苯二甲酸、柠檬酸、琥珀酸、乙酸、富马酸、苹果酸及乳酸等有机酸或它们的盐(柠檬酸钠)、磷酸(正磷酸)等无机酸或它们的盐(例如,钾盐、钠盐及铵盐)、氢氧化钠、氢氧化钾等氢氧化物。作为无机酸盐,例如可举出磷酸氢二钠、磷酸二氢钠。
pH调节剂的含量通常设为能够使添加后的口腔用组合物的pH值为5~9,优选为6~8.5的量。
在本说明书中,pH值通常是指从测定开始起在25℃下3分钟后的值。pH值,例如,能够使用东亚电波工业株式会社制造的pH计(型号Hm-30S)进行测定。
-溶剂-
作为溶剂,例如可举出水(纯化水)、乙醇等,优选水。溶剂可以单独使用1种,也可以组合使用2种以上。
-油性成分-
作为油性成分,例如可举出角鲨烷、液体石蜡、凡士林、微晶蜡等烃类;高级醇(例如,月桂醇、鲸蜡醇、鲸蜡硬脂醇(Cetostearyl alcohol)、油醇、异硬脂醇等碳原子数为8~22的醇);高级脂肪酸(例如,月桂酸、肉豆蔻酸、油酸、异硬脂酸等碳原子数为8~22的脂肪酸)、橄榄油、蓖麻油、椰子油等植物油;肉豆蔻酸异丙酯等脂肪酸酯。
-着色剂-
作为着色剂,例如可举出红花红色素、栀子黄色素、栀子蓝色素、紫苏色素、红曲色素、红甘蓝色素、胡萝卜色素、木槿(Hibiscus)色素、可可色素、螺旋藻蓝色素、罗望子色素等天然色素、或红色2号、红色3号、红色104号、红色105号、红色106号、红色227号、黄色4号、黄色5号、绿色3号、蓝色1号等法定色素、核黄素、铜叶绿素钠、二氧化钛等。在口腔用组合物包含着色剂的情况下,其含量相对于口腔用组合物整体优选为0.00001质量%~3质量%。
-(D)成分以外的香料-
通过使口腔用组合物含有(D)成分以外的香料,能够进一步提高使用感。
作为除(D)成分以外的香料,例如,可举出茴香油、肉桂油、冬青(winter green)油、乳香油(mastic oil)、橙花油(neroli oil)(橙花油(orange flower oil))、柠檬草油、茉莉花油、玫瑰油、鸢尾油、丁香油、鼠尾草油、小豆蔻油、迷迭香油、月桂油、春黄菊油、罗勒油、马郁兰(marjoram)油、柠檬油、橙油、酸橙油、柚子油、肉豆蔻油、薰衣草油、金纽扣(paracress)油、香草油、肉桂油、甘椒油、桂叶油、紫苏油、冬青油等天然精油;肉桂醛、茴香脑、水杨酸甲酯、丁香酚、芳樟醇、柠檬烯、薄荷酮、乙酸薄荷酯、柠檬醛、癸醛、樟脑、冰片(Borneol)、蒎烯、千日菊酰胺、正癸醇、香茅醇、α-松油醇、乙酸香茅酯、乙基芳樟醇、香草醛(vanillin)等上述天然精油中含有的香料成分;乙酸乙酯、丁酸乙酯、乙酸异戊酯、己醛、己烯醛、氨茴酸甲酯(methyl anthranilate)、甲基苯基缩水甘油酸乙酯(ethylmethylphenylglycidate)、苯甲醛、香草醛、乙基香草醛、呋喃酮等香料成分;以及将几个香料成分、天然精油组合而成的薄荷系、水果系、草药系等各种调合香精。作为香料,可以单独使用1种上述例示的香料,也可以组合使用2种以上。
-其他任意成分-
作为上述以外的任意成分的例子,可举出聚异丁烯、聚丁二烯、氨基甲酸酯、硅、天然橡胶。这些其他任意成分的含量能够在不妨碍本发明的效果的范围内适当设定。
[口腔用组合物的剂型和用途]
本发明的口腔用组合物能够制成洁齿剂、漱口剂、喷雾剂、涂布剂、贴附剂、或口腔内溶解剂等口腔用制剂。口腔用组合物的剂型能够根据利用方式适当选择,没有特别限定。作为剂型,例如,能够以糊状、液状等形式,如果是洁齿剂,则能够制成膏状洁齿剂、凝胶状洁齿剂、液体洁齿剂、液状洁齿剂、湿润洁齿剂。
口腔用组合物的制造方法
口腔用组合物的制造方法没有特别限定,能够根据剂型通过各种通常的方法制造得到。例如,作为牙膏使用时,可举出在制备溶解于溶剂中的成分后,混合除此以外的不溶性成分,根据需要进行脱泡(例如,减压等)的方法。所得到的牙膏可以容纳于容器中而制成产品。容器的形状、材质没有特别限制,能够使用通常的洁齿剂组合物(牙膏)中使用的容器,例如可举出聚乙烯、聚丙烯、聚对苯二甲酸乙二醇酯、尼龙等塑料制层压管等容器等。
实施例
以下,示出实施例、比较例及参考例来具体说明本发明。本发明不限于下述实施例。应予说明,下述表中的数值只要没有特别说明则为纯分量,表示质量%。
[实施例、比较例及参考例中使用的成分]
-(A)成分-
氯化十六烷基吡啶鎓:(富士胶片和光纯药株式会社制造)
异丙基甲基苯酚:(大阪化成株式会社制造)
月桂酰肌氨酸钠:(日光化学株式会社制造)
1,8-桉树脑:(株式会社永广堂本店制造)
-(B)成分-
N-(2-羟基-2-苯基乙基)-2-异丙基-5,5-二甲基环己烷-1-甲酰胺:(高砂香料工业株式会社制造,商品名:Coolact(注册商标)370)
N-(乙氧羰基甲基)-对薄荷烷-3-甲酰胺:(WS-5,丰玉香料株式会社制造)
-比较例中代替(B)成分使用的香料成分-
N-乙基-对薄荷烷-3-甲酰胺:(WS-3、德之馨(Symrise)日本公司制造)
-(C)成分-
聚氧乙烯(20)氢化蓖麻油:(日本乳液株式会社制造)
-(D)成分-
薄荷醇:(高砂香料工业株式会社制造)
香芹酮:(盐野香料株式会社制造)
薄荷油(高砂香料工业株式会社制造)
日本薄荷油(V.MANE FILS香料公司制造)
留兰香油(V.MANE FILS香料公司制造)
-任意成分-
研磨性二氧化硅:(Solvay制造Tixosil(注册商标)73)
氟化钠:(Stella Chemifa株式会社制造)
月桂基硫酸钠:(BASFJapan株式会社制造)
山梨醇液(70%):(三菱商事生命科学株式会社制造)
丙二醇:(株式会社ADEKA制造)
增稠性二氧化硅:Carplex(注册商标)#67(DSL日本株式会社制造)
糖精钠:(爱三化学工业株式会社制造)
水(纯化水)
关于上述以外的成分,均使用符合准医药品原料规格2006的原料。
实施例1~30、比较例1~4
通过常规方法使含有上述成分,制备具有下述表1~4所示组成的牙膏组合物(牙膏),将其收纳于层压管中。
[评价方法]
通过4名受试者小组成员,评价牙膏组合物的使用感。将1g牙膏组合物样品放置于牙刷(Clinica Advantage牙刷,4排紧凑普通型,狮王株式会社制造)上,刷牙3分钟,按照下述所示的评分基准,分别判定开始刷牙时的清凉感、刷牙中无苦味、刷牙后无苦味的持续性。求出4人的分数的平均值,并根据以下评价基准进行评价。
<开始刷牙时的清凉感>
关于开始刷牙时的清凉感,对开始刷牙时的清凉感进行评价。
评价基准
4分:感觉到非常有清凉感
3分:感觉到清凉感
2分:几乎感觉不到清凉感
1分:没有感觉到清凉感
判定基准
优:平均分为3.5分以上且小于4.0分
良:平均分为3.0分以上且小于3.5分
合格:平均分为2.0分以上且小于3.0分
不合格:平均分小于2.0分
<开始刷牙时无苦味>
关于无苦味,根据开始刷牙时的苦味强度进行评价。
评分基准
4分:未感觉到苦味
3分:几乎感觉不到苦味
2分:感觉到苦味
1分:非常强烈地感觉到苦味
判定基准
优:平均分为3.5分以上且4.0分以下
良:平均分为3.0分以上且小于3.5分
合格:平均分为2.0分以上且小于3.0分
不合格:平均分小于2.0分
<刷牙中无苦味>
关于刷牙中无苦味,根据刷牙3分钟的期间的苦味强度进行评价。
评价基准
4分:未感觉到苦味
3分:几乎感觉不到苦味
2分:感觉到苦味
1分:非常强烈地感觉到苦味
判定基准
优秀:平均分为3.8分以上且4.0分以下
优:平均分为3.5分以上且小于3.8分
良:平均分为3.0分以上且小于3.5分
合格:平均分为2.0分以上且小于3.0分
不合格:平均分小于2.0分
<刷牙后无苦味的持续性>
关于刷牙后无苦味的持续性,刷牙3分钟,关于冲洗后未感到苦味的时间进行评价。
评价基准
4分:25分钟以上(未感觉到苦味)
3分:15分钟以上且小于25分钟
2分:5分钟以上且小于15分钟
1分:小于5分钟
判定基准
优秀:平均分为3.8分以上且4.0分以下
优:平均分为3.5分以上且小于3.8分良:平均分为3.0分以上且小于3.5分合格:平均分为2.0分以上且小于3.0分不合格:平均分小于2.0分
[表1]
*香料:不包括薄荷醇、香芹酮、含有它们的精油。
[表2]
*香料:不包括薄荷醇、香芹酮、含有它们的精油
[表3]
*香料:不包括薄荷醇、香芹酮、含有它们的精油。
[表4]
*香料:不包括薄荷醇、香芹酮、含有它们的精油。
在不含有(B)成分的比较例1~3中,开始刷牙时几乎没有感觉到清凉感,而非常强烈地感觉到苦味,进而在刷牙中也感觉到苦味,因此使用感不佳。刷牙后无苦味的持续时间小于5分钟,未能得到令人满意的结果。另外,在使用N-乙基-对薄荷烷-3-甲酰胺代替(B)成分的比较例4情况下也得到了相同的结果。与此相对,含有(A)成分和(B)成分的实施例1~30在全部的评价项目中均得到了平均分3.0以上的令人满意的结果。其中,在除了(A)成分和(B)成分之外还含有(C)成分的实施例21~30中,刷牙中无苦味和刷牙后无苦味的持续性的评价提高到平均分3.8以上,得到了优异的结果。这些结果表明,本发明涉及的口腔用组合物在使用开始时赋予清凉感,从使用开始到使用后经过一定时间后,能够抑制来自杀菌剂的苦味,进而能够使抑制作用持续。
Claims (12)
1.一种口腔用组合物,其特征在于,所述口腔用组合物含有:
(A)杀菌剂,以及
(B)选自由N-(乙氧羰基甲基)-对薄荷烷-3-甲酰胺和N-(2-羟基-2-苯基乙基)-2-异丙基-5,5-二甲基环己烷-1-甲酰胺组成的组中的1种以上。
2.根据权利要求1所述的口腔用组合物,其中,
(A)成分为选自由阳离子型杀菌剂、非离子型杀菌剂和阴离子型杀菌剂组成的组中的1种以上的杀菌剂。
3.根据权利要求1或2所述的口腔用组合物,其中,
(A)成分为选自由季铵盐、双胍系杀菌剂、酚系杀菌剂、桉树脑和酰基肌氨酸盐组成的组中的1种以上的杀菌剂。
4.根据权利要求1~3中任一项所述的口腔用组合物,其中,
相对于口腔用组合物100质量%,(A)成分的含量为0.001质量%~0.5质量%。
5.根据权利要求1~4中任一项所述的口腔用组合物,其中,
相对于口腔用组合物100质量%,(B)成分的含量为0.00001质量%~0.1质量%。
6.根据权利要求1~5中任一项所述口腔用组合物,其中,
所述口腔用组合物还含有(C)非离子表面活性剂。
7.根据权利要求6所述的口腔用组合物,其中,
(C)成分为选自由聚氧乙烯氢化蓖麻油、聚氧乙烯烷基醚、聚甘油脂肪酸酯和聚氧乙烯聚氧丙烯共聚物组成的组中的1种以上的非离子表面活性剂。
8.根据权利要求6或7所述的口腔用组合物,其中,
相对于口腔用组合物100质量%,(C)成分的含量为0.1质量%~2质量%。
9.根据权利要求1~8中任一项所述的口腔用组合物,其中,
所述口腔用组合物还含有(D)清凉剂。
10.根据权利要求9所述的口腔用组合物,其中,
(D)成分为薄荷醇和香芹酮中的任一者或两者,或者为包含薄荷醇和香芹酮中的任一者或两者的精油。
11.根据权利要求9或10所述的口腔用组合物,其中,
相对于口腔用组合物100质量%,(D)成分的含量以薄荷醇和香芹酮中的任一者或两者的含量计,为0.001质量%~1.5质量%。
12.根据权利要求1~11中任一项所述的口腔用组合物,其中,
所述口腔用组合物为洁齿剂、漱口剂、喷雾剂、涂布剂、贴附剂或口腔内溶解剂。
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