CN102727407A - Health-care toothpaste containing Chinese prickly ash extracts - Google Patents
Health-care toothpaste containing Chinese prickly ash extracts Download PDFInfo
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- CN102727407A CN102727407A CN2012100926896A CN201210092689A CN102727407A CN 102727407 A CN102727407 A CN 102727407A CN 2012100926896 A CN2012100926896 A CN 2012100926896A CN 201210092689 A CN201210092689 A CN 201210092689A CN 102727407 A CN102727407 A CN 102727407A
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Abstract
The invention, relating to the field of chemicals for daily use, especially relates to an application of Chinese prickly ash extracts in toothpaste. The invention further discloses health-care toothpaste and a health-care toothpaste additive. The health-care toothpaste comprises 0.1-3.5 wt% of Chinese prickly ash extracts containing no less than 30 wt% of extracts of volatile oil from Chinese prickly ash. The toothpaste additive comprises 0.1-3.5 weight parts of Chinese prickly ash extracts, and 0.1-2.5 weight parts of eugenol. According to the invention, the health-care toothpaste containing Chinese prickly ash extracts of the invention adopts Chinese prickly ash extracts and eugenol which have antibacterial action and analgesia action, thus the toothpaste has no toxicity and no side effect to human's bodies, and the safety of the toothpaste is greatly better than synthetic antibacterial agents; the synergistic effect of Chinese prickly ash extracts and eugenol can enhance the antimicrobial antibacterial functions, and the purposes of diminishing inflammation, easing pain, removing halitosis, improving gingivitis and oral ulcer, cleaning oral cavity and carrying out oral health are achieved.
Description
Technical field
The present invention relates to filed of daily-use chemical industry, relate in particular to a kind of pepper Healthy toothpaste.
Background technology
Toothpaste is dental care products essential in the daily life.Its major function is a cleaning oral cavity, gives salubrious comfortable implication after the use.In recent years, along with improving constantly of consumer oral cavity health consciousness, and natural, green, the enhancing of safe consumption theory, people proposed more requirement to toothpaste, and various medicated toothpaste with health care emerge in large numbers on market.Though existing Chinese herbal toothpaste has certain inhibition oral cavity noxious bacteria, fresh breath, take care of one's teeth, prevent and treat function such as oral disease, because the medicinal herb components that uses is more single, the tooth protection health-care effect is not ideal enough.Though and the medicated toothpaste effect of adding chemicals is obvious, there is the safety issue to human body in life-time service.At present, on the market also rarely seen employing natural plant extracts at the health-care toothpaste that reaches produce effects aspect the curative effect health care of oral cavity.
Pericarpium Zanthoxyli is the spice of using always, also is the very high Chinese medicine of a kind of medical value, and it is warm in nature, and acrid in the mouth has warming spleen and stomach for dispelling cold, the effect of antibiotic, dehumidifying, analgesia, parasite killing etc.The traditional Chinese medical science is used for treatment vomiting, anemofrigid-damp arthralgia, diseases such as toothache.Compendium of Material Medica record: " Pericarpium Zanthoxyli hard tooth, black hair, make eye bright, clothes for a long time, good color, anti-old, increase year, strong refreshing." Pericarpium Zanthoxyli mainly contains number of chemical compositions such as volatile oil, alkaloid, modern medicine proves, Pericarpium Zanthoxyli can the enhances human body immunocompetence, can strengthen the sterilizing power of neutrophilic leukocyte, and can strengthen the phagocytic function of macrophage; Fructus Zanthoxyli extract has pharmacological actions such as anesthesia, pain relieving, antibiotic, antitumor, anthelmintic.Experiment shows that Fructus Zanthoxyli extract all has various pathogenic bacterium significantly to be killed and inhibitory action.The spicy component of Pericarpium Zanthoxyli also has very strong persistence analgesic activity.Utilize the antibiotic and analgesic properties of Fructus Zanthoxyli extract, assistant is joined the eugenol natural antibacterial agent that derives from plant of clove, and the exploitation health-care toothpaste is expected to reach ideal effect, and it is efficient, the demand of the characteristic conforms modern consumer of natural and safe.This type of research at present and product all do not appear in the newspapers in all kinds of documents.
Summary of the invention
The object of the present invention is to provide a kind of new application of Fructus Zanthoxyli extract, this preparation that is applied as toothpaste provides new approaches.
For realizing above-mentioned purpose, technical scheme of the present invention is:
The application of Fructus Zanthoxyli extract in the preparation health-care toothpaste, said Fructus Zanthoxyli extract is meant the extract that contains Pericarpium Zanthoxyli volatile oil that from Pericarpium Zanthoxyli, extracts.
Further, said Fructus Zanthoxyli extract is meant the extract that contains Pericarpium Zanthoxyli volatile oil and fiber crops element that from Pericarpium Zanthoxyli, extracts.
Further, said Fructus Zanthoxyli extract is meant Pericarpium Zanthoxyli removal cellulose and lignin residue afterwards.
Two of the object of the invention is to provide a kind of health-care toothpaste and toothpaste additive, and it has significant analgesic activity; Said toothpaste additive has anti-inflammatory analgesic, antihalitosis, improves the effect of gingivitis and oral ulcer.
For realizing above-mentioned purpose, technical scheme of the present invention is:
The health-care toothpaste that contains Fructus Zanthoxyli extract contains the Fructus Zanthoxyli extract that mass fraction is 0.1-3.5% in the said health-care toothpaste, said Fructus Zanthoxyli extract is to contain the extract that mass fraction is no less than 30% Pericarpium Zanthoxyli volatile oil.
Further, contain the Fructus Zanthoxyli extract of mass fraction 1.0% in the said health-care toothpaste, it is that 36% Pericarpium Zanthoxyli volatile oil and mass fraction are that 6% fiber crops are plain that said Fructus Zanthoxyli extract contains mass fraction.
Further; Said Fructus Zanthoxyli extract obtains through following method: Pericarpium Zanthoxyli is pulverized, inserted extraction kettle, feed supercritical carbon dioxide with the 350-450L/h flow velocity; In temperature is that 35-50 ℃, pressure are to extract under the 25-30MPa condition; 1.5-2.5 hour extraction time, emit extract from knockout drum, said extract is a Fructus Zanthoxyli extract.
Further, described health-care toothpaste is composed of the following components by mass parts: Fructus Zanthoxyli extract 0.1-3.5 part, eugenol 0.1-2.5 part, calcium carbonate 40-50 part; Sorbitol 15-25 part, silicon dioxide 3-7 part, glycerol 3-6 part, sodium carboxymethyl cellulose 0.2-1.5 part; Xanthan gum 0.2-0.5 part, sodium laurylsulfate 1.5-2.5 part, polyoxyethylene (20) sorbitan mono-oleic acid ester 0.5-1.5 part; Essence 0.3-1.0 part, saccharin sodium 0.1-0.2 part, deionized water 15-30 part.
Further; Described health-care toothpaste; Composed of the following components by mass parts: 1.5 parts of 1.5 parts, eugenol, 40 parts of calcium carbonate, 15 parts of sorbitol, 4 parts of silicon dioxide, 3 parts of glycerol, 1.0 parts of sodium carboxymethyl cellulose, 0.3 part of xanthan gum, 2.5 parts of sodium laurylsulfates, 1.0 parts of polyoxyethylene (20) sorbitan mono-oleic acid esters, 0.3 part in essence, 0.15 part of saccharin sodium, 30 parts of deionized waters.
Contain the toothpaste additive of Fructus Zanthoxyli extract, composed of the following components by mass parts:
Fructus Zanthoxyli extract 0.1-3.5 part; Eugenol 0.1-2.5 part; Said Fructus Zanthoxyli extract be meant from Pericarpium Zanthoxyli, extract contain Pericarpium Zanthoxyli volatile oil and the plain extract of fiber crops, contain mass fraction in the said Fructus Zanthoxyli extract and be no less than 30% Pericarpium Zanthoxyli volatile oil and be no less than 5% fiber crops element with mass fraction.
Further, toothpaste additive is composed of the following components by mass parts:
1.0 parts of Fructus Zanthoxyli extracts, 0.5 part of eugenol; Said Fructus Zanthoxyli extract obtains through following steps: said Fructus Zanthoxyli extract is to obtain through following method: Pericarpium Zanthoxyli is pulverized; Insert extraction kettle; Feeding supercritical carbon dioxide with the 350-450L/h flow velocity, is that 35-50 ℃, pressure are to extract under the 25-30MPa condition in temperature, extracts time 1.5-2.5 hour; Emit extract from knockout drum, said extract is a Fructus Zanthoxyli extract.
Beneficial effect of the present invention is: used antibiotic in the pepper Healthy toothpaste of the present invention and Fructus Zanthoxyli extract and eugenol analgesic activity.Modern study proves, Fructus Zanthoxyli extract has pharmacological actions such as anesthesia, pain relieving, antibiotic, antitumor, anthelmintic.As natural antibacterial agent anthrax bacillus, Hemolytic streptococcus, diphtheria corynebacterium, Diplococcus pneumoniae, staphylococcus aureus, Staphylococcus albus, bacillus subtilis, escherichia coli, dysentery bar flute, Bacillus proteus, bacillus pyocyaneus, vibrio cholera etc. are all had and significantly to kill and inhibitory action.The spicy component of Fructus Zanthoxyli extract has very strong persistence analgesic activity, aspect treatment toothache, the dental caries good synergism is being arranged.Eugenol is the natural antibacterial agent that derives from plant of clove, has very strong sterilizing power, and is safe and harmless to human body.Eugenol has effects such as analgesia anesthesia, antibacterial bacteriostatic, antioxidation, analgesic, antitumor, promotion Transdermal absorption.Experiment shows that various pathogens such as the anaerobe of eugenol boil on the nape opposite the mouth intracavity growth, escherichia coli, staphylococcus aureus, streptococcus, dysentery bacterium, tubercule bacillus all have antibacterial preferably and fungistatic effect.These two kinds of antibacterial all be edible, human body is had no the pure natural antibacterial agent of toxic and side effects, safety is superior to synthetic antibacterial agents greatly.Toothpaste of the present invention is with two kinds of composite uses of natural agents, and its cooperative effect can strengthen the antibacterial bacteriostatic ability of toothpaste, reaches anti-inflammatory analgesic, antihalitosis, improves gingivitis, oral ulcer, the purpose of cleaning and health care that the oral cavity carried out.This method for preparing technology is simple, produces easy to controlly, is suitable for suitability for industrialized production.
The specific embodiment
In order to make the object of the invention, technical scheme and advantage clearer, carry out detailed description in the face of the preferred embodiments of the present invention down.
The extraction of embodiment 1 Fructus Zanthoxyli extract
The 12000g dry Pericarpium Zanthoxyli being pulverized, inserted extraction kettle, feed supercritical carbon dioxide with the 430L/h flow velocity, is that 50 ℃, pressure are to extract under the 25MPa condition in temperature, and extraction time 2h emits extract from knockout drum, promptly gets the 996g Fructus Zanthoxyli extract.It is that 36% Pericarpium Zanthoxyli volatile oil and mass fraction are that 6% fiber crops are plain that said Fructus Zanthoxyli extract contains mass fraction.
Except extracting with said method, steam distillation, vegetable oil extraction, edible ethanol extraction method, dehydrated alcohol extraction method or the supercritical carbon dioxide extraction method acquisition Fructus Zanthoxyli extract that also can adopt people such as monarch Meng Qing in " Different Extraction Method is to the influence of Fructus Zanthoxyli extract extraction ratio and quality ", to mention; Adopt diverse ways, in the Fructus Zanthoxyli extract of acquisition, the yield of Pericarpium Zanthoxyli volatile oil is different.Among the present invention, no matter adopt which kind of method, purpose all is to obtain Fructus Zanthoxyli extract.Wide in range understanding, said Fructus Zanthoxyli extract are meant the extract that contains Pericarpium Zanthoxyli volatile oil that from Pericarpium Zanthoxyli, extracts.Further limit, said Fructus Zanthoxyli extract is meant the extract that contains Pericarpium Zanthoxyli volatile oil and fiber crops element that from Pericarpium Zanthoxyli, extracts.Further limit, said Fructus Zanthoxyli extract is meant the residue after Pericarpium Zanthoxyli removal cellulose and the lignin again.The quality of the Pericarpium Zanthoxyli volatile oil that contains in the said Fructus Zanthoxyli extract is at least 30% of said Fructus Zanthoxyli extract.Contain linalool, limonene, sabinene, ocimene, myrcene, β-phellandrene, 1 in the Pericarpium Zanthoxyli volatile oil, any one or more material in 8-cineole, ethyl dimethyl, linalyl butyrate, β-caryophyllene, 3 Methylbutanoic acid ethyl ester, germacrene, γ-Song Youxi, β-thujone, alpha-terpineol, the nerolidol.
Through evidence, the Fructus Zanthoxyli extract that present embodiment obtains has pharmacological actions such as anesthesia, pain relieving, antibiotic, anthelmintic.As natural antibacterial agent anthrax bacillus, Hemolytic streptococcus, diphtheria corynebacterium, Diplococcus pneumoniae, staphylococcus aureus, Staphylococcus albus, bacillus subtilis, escherichia coli, dysentery bar flute, Bacillus proteus, bacillus pyocyaneus, vibrio cholera etc. are all had and significantly to kill and inhibitory action.The spicy component of Fructus Zanthoxyli extract (fiber crops are plain) has very strong persistence analgesic activity, aspect treatment toothache, the dental caries good synergism is being arranged.So Fructus Zanthoxyli extract can be used for preparing health-care toothpaste, this health-care toothpaste possesses pain relieving and antimicrobial effect.The fiber crops element is an amides compound; Be the spicy component that from Pericarpium Zanthoxyli, extracts, be one or more materials in α-sanshool, hydroxyl-α-sanshool, hydroxy-beta-sanshool, γ-sanshool, hydroxyl γ-sanshool, different-hydroxyl-γ-sanshool, dehydrogenation-γ-sanshool, xanthoxlin, different xanthoxlin, two hydrogen xanthoxlin or the tetrahydrochysene xanthoxlin with intense stimulus property.In Meng Yijuan " method for distilling of Pericarpium Zanthoxyli fiber crops flavor material and the industrialization of a Pericarpium Zanthoxyli " literary composition, the method for distilling of fiber crops plain (being Pericarpium Zanthoxyli fiber crops flavor material) comprises steam distillation, organic solvent extraction method and supercritical carbon dioxide extraction method.
The preparation of embodiment 2 health-care toothpastes
Take by weighing 3.5 parts of Fructus Zanthoxyli extracts (it is 36% Pericarpium Zanthoxyli volatile oil that said Fructus Zanthoxyli extract contains mass fraction and mass fraction is 6% fiber crops element), eugenol 0.1, calcium carbonate 45, sorbitol 20, silicon dioxide 7, glycerol 6, sodium carboxymethyl cellulose 0.2, xanthan gum 0.5, sodium laurylsulfate 2.0, polyoxyethylene (20) sorbitan mono-oleic acid ester 0.5, essence 1.0, saccharin sodium 0.1, the deionized water 15 of embodiment 1 preparation by mass parts.Deionized water, sorbitol, glycerol, polyoxyethylene (20) sorbitan mono-oleic acid ester, saccharin sodium, sodium carboxymethyl cellulose, xanthan gum, sodium laurylsulfate are added in the Manufacturing medicine extract machine stirring and evenly mixing by said formula ratio; Add calcium carbonate, silicon dioxide and said toothpaste additive (Fructus Zanthoxyli extract and eugenol), high-speed stirred, homogenizing; Add essence then, carry out high-speed stirred once more, homogenizing promptly makes lotion of toothpaste.
The preparation of embodiment 3 health-care toothpastes
Take by weighing 0.1 part of Fructus Zanthoxyli extract (it is 36% Pericarpium Zanthoxyli volatile oil that said Fructus Zanthoxyli extract contains mass fraction and mass fraction is 6% fiber crops element), 2.5 parts of eugenol, 50 parts of calcium carbonate, 25 parts of sorbitol, 3 parts of silicon dioxide, 5 parts of glycerol, 1.5 parts of sodium carboxymethyl cellulose, 0.2 part of xanthan gum, 1.5 parts of sodium laurylsulfates, 1.5 parts of polyoxyethylene (20) sorbitan mono-oleic acid esters, 0.5 part in essence, 0.2 part of saccharin sodium, 20 parts of the deionized waters of embodiment 1 preparation by mass parts.Deionized water, sorbitol, glycerol, polyoxyethylene (20) sorbitan mono-oleic acid ester, saccharin sodium, sodium carboxymethyl cellulose, xanthan gum, sodium laurylsulfate are added in the Manufacturing medicine extract machine stirring and evenly mixing by said formula ratio; Add calcium carbonate, silicon dioxide and said toothpaste additive, high-speed stirred, homogenizing; Add essence then, carry out high-speed stirred once more, homogenizing promptly makes lotion of toothpaste.
The preparation of embodiment 4 health-care toothpastes
Take by weighing 1.0 parts of Fructus Zanthoxyli extracts (it is 36% Pericarpium Zanthoxyli volatile oil that said Fructus Zanthoxyli extract contains mass fraction and mass fraction is 6% fiber crops element), 0.5 part of eugenol, 42 parts of calcium carbonate, 16 parts of sorbitol, 4 parts of silicon dioxide, 4 parts of glycerol, 1.2 parts of sodium carboxymethyl cellulose, 0.3 part of xanthan gum, 2.4 parts of sodium laurylsulfates, 1.0 parts of polyoxyethylene (20) sorbitan mono-oleic acid esters, 0.4 part in essence, 0.15 part of saccharin sodium, 28 parts of the deionized waters of embodiment 1 preparation by mass parts.Deionized water, sorbitol, glycerol, polyoxyethylene (20) sorbitan mono-oleic acid ester, saccharin sodium, sodium carboxymethyl cellulose, xanthan gum, sodium laurylsulfate are added in the Manufacturing medicine extract machine stirring and evenly mixing by said formula ratio; Add calcium carbonate, silicon dioxide and said toothpaste additive, high-speed stirred, homogenizing; Add essence then, carry out high-speed stirred once more, homogenizing promptly makes lotion of toothpaste.
The preparation of embodiment 5 health-care toothpastes
Take by weighing 1.5 parts of Fructus Zanthoxyli extracts (it is 36% Pericarpium Zanthoxyli volatile oil that said Fructus Zanthoxyli extract contains mass fraction and mass fraction is 6% fiber crops element), 1.5 parts of eugenol, 40 parts of calcium carbonate, 15 parts of sorbitol, 5 parts of silicon dioxide, 3 parts of glycerol, 1.0 parts of sodium carboxymethyl cellulose, 0.3 part of xanthan gum, 2.5 parts of sodium laurylsulfates, 1.0 parts of polyoxyethylene (20) sorbitan mono-oleic acid esters, 0.3 part in essence, 0.15 part of saccharin sodium, 30 parts of the deionized waters of embodiment 1 preparation by mass parts.Deionized water, sorbitol, glycerol, polyoxyethylene (20) sorbitan mono-oleic acid ester, saccharin sodium, sodium carboxymethyl cellulose, xanthan gum, sodium laurylsulfate are added in the Manufacturing medicine extract machine stirring and evenly mixing by said formula ratio; Add calcium carbonate, silicon dioxide and said toothpaste additive, high-speed stirred, homogenizing; Add essence then, carry out high-speed stirred once more, homogenizing promptly makes lotion of toothpaste.
The antibacterial tests of embodiment 6 pepper Healthy toothpaste
1. BA
Test organisms is staphylococcus aureus ATCC6538 strain, escherichia coli 8099 strains. white beads ATCC10231 strain.Adopt carrier quantitative germicidal test, test carrier is 10mm * 10mm slide, behind pressuresteam sterilization, dyes the method microbiological contamination with dripping.Every of bacterium drop dosage is 0.01ml, and every microbiological contamination amount is 5 * 10
5Cfu/ml-5 * 10
6Cfu/ml is behind the microbiological contamination liquid. and place 37 ℃ of incubator inner drying 30min. to be used for test.During test. bacterium sheet microbiological contamination face is covered in the health-care toothpaste of embodiment 5 preparations; After waiting to affact the scheduled time; Take out the bacterium sheet; Immigration contains in the conical flask of bead and 10ml nertralizer. and put and shake 2min (365 times/minute) on the Kang Shi oscillator. get its stock solution or different dilution diluent 0.5ml, make count plate with tilt-pour process.All test samples all place cultivates 48h in 37 ℃ of incubators, observe final result.
2. result of the test
The killing action of toothpaste that adopted the carrier test method determination, toothpaste to staphylococcus aureus ATCC6538 strain, escherichia coli 8099 strains and Candida albicans ATCC10231 strain in 1min to the killing rate of staphylococcus aureus, escherichia coli and Candida albicans respectively 99.99%, 99.98% and 99.97%.3min all reaches 100%.
The test of embodiment 7 pepper Healthy toothpaste results of use
Select 80 experimenters to test.Choice criteria: select case by the conventional diagnostic criteria of assert of medical treatment.Subject age: 20-60 year; Sex: 40 of men, 40 of woman;
Method for using: the health-care toothpaste every day of each use sooner or later with embodiment 4 preparations once each 3-5 minute, between the operating period, does not add and uses other drug.Criterion of therapeutical effect: a, effect are remarkable: symptom disappears basically; B, effective: symptom takes a turn for the better; C, invalid: no positive effect.The observation of curative effect result: observed 5-14 days, the result sees table 1.
Table 1 toothpaste result on trial of the present invention
| Disease | Experimenter's number | Produce effects | Effectively | Invalid | Effective percentage % |
| Toothache | 20 | 17 | 1 | 2 | 90 |
| Halitosis | 20 | 17 | 2 | 1 | 95 |
| Gingivitis | 20 | 14 | 3 | 3 | 85 |
| Oral ulcer | 20 | 15 | 3 | 2 | 90 |
Explanation is at last; Above embodiment is only unrestricted in order to technical scheme of the present invention to be described; Although with reference to preferred embodiment the present invention is specified, those of ordinary skill in the art should be appreciated that and can make amendment or be equal to replacement technical scheme of the present invention; And not breaking away from the aim and the scope of technical scheme of the present invention, it all should be encompassed in the middle of the claim scope of the present invention.
Claims (10)
1. the application of Fructus Zanthoxyli extract in the preparation health-care toothpaste, it is characterized in that: said Fructus Zanthoxyli extract is meant the extract that contains Pericarpium Zanthoxyli volatile oil that from Pericarpium Zanthoxyli, extracts.
2. application according to claim 1, said Fructus Zanthoxyli extract are meant the extract that contains Pericarpium Zanthoxyli volatile oil and fiber crops element that from Pericarpium Zanthoxyli, extracts.
3. application according to claim 1 is characterized in that, said Fructus Zanthoxyli extract is meant the residue after Pericarpium Zanthoxyli removal cellulose and the lignin.
4. contain the health-care toothpaste of Fructus Zanthoxyli extract, it is characterized in that: contain the Fructus Zanthoxyli extract that mass fraction is 0.1-3.5% in the said health-care toothpaste, said Fructus Zanthoxyli extract is to contain the extract that mass fraction is no less than 30% Pericarpium Zanthoxyli volatile oil.
5. health-care toothpaste according to claim 4 is characterized in that: contain the Fructus Zanthoxyli extract of mass fraction 1.0% in the said health-care toothpaste, it is plain to contain mass fraction in the said Fructus Zanthoxyli extract and be 36% Pericarpium Zanthoxyli volatile oil and mass fraction and be 6% fiber crops.
6. health-care toothpaste according to claim 4; It is characterized in that: said Fructus Zanthoxyli extract obtains through following method: Pericarpium Zanthoxyli is pulverized, inserted extraction kettle, feed supercritical carbon dioxide with the 350-450L/h flow velocity; In temperature is that 35-50 ℃, pressure are to extract under the 25-30MPa condition; 1.5-2.5 hour extraction time, emit extract from knockout drum, said extract is a Fructus Zanthoxyli extract.
7. health-care toothpaste according to claim 6 is characterized in that, and is composed of the following components by mass parts: Fructus Zanthoxyli extract 0.1-3.5 part; Eugenol 0.1-2.5 part, calcium carbonate 40-50 part, sorbitol 15-25 part; Silicon dioxide 3-7 part, glycerol 3-6 part, sodium carboxymethyl cellulose 0.2-1.5 part; Xanthan gum 0.2-0.5 part, sodium laurylsulfate 1.5-2.5 part, polyoxyethylene (20) sorbitan mono-oleic acid ester 0.5-1.5 part; Essence 0.3-1.0 part, saccharin sodium 0.1-0.2 part, deionized water 15-30 part.
8. health-care toothpaste according to claim 7; It is characterized in that; Composed of the following components by mass parts: 1.5 parts of 1.5 parts, eugenol, 40 parts of calcium carbonate, 15 parts of sorbitol, 4 parts of silicon dioxide, 3 parts of glycerol, 1.0 parts of sodium carboxymethyl cellulose, 0.3 part of xanthan gum, 2.5 parts of sodium laurylsulfates, 1.0 parts of polyoxyethylene (20) sorbitan mono-oleic acid esters, 0.3 part in essence, 0.15 part of saccharin sodium, 30 parts of deionized waters.
9. contain the toothpaste additive of Fructus Zanthoxyli extract, it is characterized in that, composed of the following components by mass parts:
Fructus Zanthoxyli extract 0.1-3.5 part; Eugenol 0.1-2.5 part; Said Fructus Zanthoxyli extract be meant from Pericarpium Zanthoxyli, extract contain Pericarpium Zanthoxyli volatile oil and the plain extract of fiber crops, contain mass fraction in the said Fructus Zanthoxyli extract and be no less than 30% Pericarpium Zanthoxyli volatile oil and be no less than 5% fiber crops element with mass fraction.
10. toothpaste additive according to claim 9 is characterized in that, and is composed of the following components by mass parts:
1.0 parts of Fructus Zanthoxyli extracts, 0.5 part of eugenol; Said Fructus Zanthoxyli extract obtains through following steps: said Fructus Zanthoxyli extract is to obtain through following method: Pericarpium Zanthoxyli is pulverized; Insert extraction kettle; Feeding supercritical carbon dioxide with the 350-450L/h flow velocity, is that 35-50 ℃, pressure are to extract under the 25-30MPa condition in temperature, extracts time 1.5-2.5 hour; Emit extract from knockout drum, said extract is a Fructus Zanthoxyli extract.
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| CN107320402A (en) * | 2017-08-24 | 2017-11-07 | 何家平 | A kind of antiodontalgic toothpaste technique |
| CN108635310A (en) * | 2018-08-14 | 2018-10-12 | 海南金香远药业科技有限公司 | Inflammation-diminishing toothpaste and preparation method thereof |
| CN109157424A (en) * | 2018-10-12 | 2019-01-08 | 赵孔发 | A kind of preparation method and applications of Japan pepper essential oil microcapsules |
| JP2020011951A (en) * | 2018-07-06 | 2020-01-23 | ライオン株式会社 | Oral composition |
| CN110731935A (en) * | 2019-12-13 | 2020-01-31 | 汉源县昊业花椒产业研究院 | toothpaste for diminishing inflammation and relieving pain |
| CN111434329A (en) * | 2019-01-11 | 2020-07-21 | 薪火炙药(北京)科技有限公司 | Antibacterial anti-inflammatory health-care toothpaste containing pepper extract |
| WO2021015091A1 (en) * | 2019-07-23 | 2021-01-28 | ライオン株式会社 | Oral composition and agent for imparting massage sensation to gums |
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| CN113491647A (en) * | 2020-04-03 | 2021-10-12 | 中国热带农业科学院农产品加工研究所 | Zanthoxylum bungeanum pain-relieving and inflammation-diminishing toothpaste and preparation method thereof |
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| CN107320402A (en) * | 2017-08-24 | 2017-11-07 | 何家平 | A kind of antiodontalgic toothpaste technique |
| JP2020011951A (en) * | 2018-07-06 | 2020-01-23 | ライオン株式会社 | Oral composition |
| JP7310357B2 (en) | 2018-07-06 | 2023-07-19 | ライオン株式会社 | oral composition |
| CN108635310A (en) * | 2018-08-14 | 2018-10-12 | 海南金香远药业科技有限公司 | Inflammation-diminishing toothpaste and preparation method thereof |
| CN109157424A (en) * | 2018-10-12 | 2019-01-08 | 赵孔发 | A kind of preparation method and applications of Japan pepper essential oil microcapsules |
| CN111434329A (en) * | 2019-01-11 | 2020-07-21 | 薪火炙药(北京)科技有限公司 | Antibacterial anti-inflammatory health-care toothpaste containing pepper extract |
| WO2021015091A1 (en) * | 2019-07-23 | 2021-01-28 | ライオン株式会社 | Oral composition and agent for imparting massage sensation to gums |
| CN110731935A (en) * | 2019-12-13 | 2020-01-31 | 汉源县昊业花椒产业研究院 | toothpaste for diminishing inflammation and relieving pain |
| CN113491647A (en) * | 2020-04-03 | 2021-10-12 | 中国热带农业科学院农产品加工研究所 | Zanthoxylum bungeanum pain-relieving and inflammation-diminishing toothpaste and preparation method thereof |
| CN112402509A (en) * | 2020-12-10 | 2021-02-26 | 王书校 | Composition for treating skin diseases, preparation method and application |
| CN112889990A (en) * | 2021-03-01 | 2021-06-04 | 中国热带农业科学院农产品加工研究所 | Composition tablet candy for relieving swelling and aching of gum and preparation method thereof |
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