KR101790034B1 - Oral composition for preventing cavity and halitosis - Google Patents

Abstract

The present invention relates to an oral composition for prevention of tooth decay and bad breath improving, comprising a mixture of cinnamon, fennel, and fennel, which is then pulverized and extracted as an active ingredient to inhibit the growth of oral cavity bacteria and improve the development of bad breath ≪ / RTI >

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to an oral composition for preventing cavities,

The present invention relates to an oral composition for prevention of tooth decay and bad breath improving, comprising a mixture of cinnamon, fennel, and fennel, which is then pulverized and extracted as an active ingredient to inhibit the growth of oral cavity bacteria and improve the development of bad breath ≪ / RTI >

As modern society becomes industrialized and westernized, the causes and symptoms of oral-related diseases are becoming diverse due to lifestyle and dietary changes, and they are reported as serious social problems. WHO recognizes oral diseases such as dental caries, periodontal disease, bad breath and oral pain as one of the major health problems to be solved in the future. According to WHO's report on dental diseases, 60-90% of adolescents worldwide and 60% of adults are suffering from dental caries and periodontal disease, and 15-20% of middle-aged adults (35-44 years) have severe periodontal disease have. These oral-related diseases are not only a major cause of tooth loss, but are also reported to be potential risk factors for diseases such as cardiovascular disease, bacterial pneumonia, low birth weight infants, diabetic complications and osteoporosis.

The human oral environment is highly humid and the body temperature is stable, so food is easy to decay and it is good for bacteria to reproduce. More than 700 different kinds of bacteria reside in human oral cavity, and oral bacteria consist of resident bacteria and pathogens. It is known that Bacillus subtilis maintains oral health by preventing propagation of pathogens, while bacteria that cause oral diseases are known to be present in plaque (plaque), a bacterial membrane formed between teeth and gums. Pathogens produce toxins and acids in the plaque (plaque), and the toxins they produce enter the periodontal tissue, causing inflammation of the gingiva, destruction of the alveolar bone, and infection. The resulting acid dissolves the tooth surface and causes dental caries, It also acts as a cause of bad breath induction.

The cause of bad breath is largely classified into internal or external cause of oral cavity. Examples of oral causes include oral microorganisms in mouth, untreated dental caries and periodontal disease, and external oral causes include respiratory Diseases, gastrointestinal disorders, and various causes such as fasting, menstruation, smoking, and drinking. Among the above-mentioned causes, bad breath is often caused by volatile sulfur compounds generated by decomposition of food waste precipitated between the teeth by microorganisms.

In general, as a method for preventing oral diseases, antibiotics such as penicillin and tetracycline, cetylpyridinium chloride, organic or inorganic fluorine-containing agents, and chlorhexidine are used to inhibit the activity of pathogens. However, the chemical agent has problems such as the appearance of resistant bacteria in the oral cavity and the adverse effects of fluorine and chlorhexidine on the human body against antibiotics.

Chlorhexidine, which is well known as an oral cleanser, has the effect of reducing the number of bacteria and inhibiting the formation of a bacterial membrane at the tooth surface. However, when used continuously, there is a side effect such as causing a burning sensation in the dental pigmented mucosa and causing coloring in the tongue and teeth. In addition, research has been reported to be ineffective for bacteria that cause dental caries.

Excessive use of such chemical agents can lead to confusion in the oral microbial gun as well as in the intestinal microbial gun, resulting in side effects such as infection by other bacteria, vomiting or diarrhea. Due to these problems, studies on natural products for prevention of dental caries and periodontal disease related to dental floss have progressed actively while preventing side effects of chemical agents. There are studies on natural materials related to oral cavity, such as pale blue cabbage (non-patent document 1), post-peeling (non-patent document 2), joan (non-patent document 3), and goat mac (non-patent document 4).

 M.K. Shin et al. Cytotoxicity and Antimicrobial Effect of the Extract of Salvia plebeia. 2001, The Korean Society for the Study of the Fauna, Vol. 32, No. 1, 55-60.  Y.S. Lee et al. Isolation of an Anticariogenic Compound from Magnoliae Bark, Korean Journal of Food Science and Technology, 30 권 1 호 230-236.  S.G. Min et al. Original Articles: Inhibitory effects of Caesalpinia sappan on growth and invasion of methicillin-resistant Staphylococcus aureus, Korean Journal of Maxillofacial Plastic and Reconstructive Surgery, Vol. 25, No. 3, 206-213.  H.H. Yu et al. Effects of Dianthus Superbus on Activity of Streptococcus Mutans, Physiology of Pathology, Vol. 24, No. 5, 854-858. Various natural extracts have been developed and applied to oral products. However, in most cases, it is difficult to prevent oral diseases such as tooth decay and bad breath due to poor antimicrobial effect. Therefore, a next generation antibacterial material having a selective effect on oral bacteria Development is required.

In order to solve the above problems, it is an object of the present invention to provide an oral composition for preventing tooth decay and bad breath, which comprises a mixed extract of cinnamon, fennel, and acacia as an active ingredient.

It is another object of the present invention to provide a method for producing a mixed extract of cinnamon, fennel and acacia.

In order to achieve the above object, the present invention provides an oral composition for prevention of tooth decay and bad breath improvement comprising a mixed extract of cinnamon, fennel and acacia as an active ingredient.

In addition, the present invention provides a method for producing a mixed extract of cinnamon, fennel and acacia.

The oral composition for prevention of tooth decay and bad breath improvement of the present invention has an effect of inhibiting the activity of the causative bacteria of cariogenic bacteria, improving halitosis, and inhibiting acid production of teeth by including mixed extracts of cinnamon, fennel, .

Hereinafter, the present invention will be described in detail.

The oral composition for prevention of tooth decay and bad breath improvement of the present invention contains mixed extracts of cinnamon, fennel, and acacia as an active ingredient.

The cinnamon is a bark of a bamboo tree, which is an evergreen tree belonging to the genus Camphoraceae. The cinnamon is sweet and sweet, and its fever is feeble. In oriental medicine, it is widely used for treating painful neuralgia and arthritic diseases, such as back and knees. Cinnamon contains ingredients such as cinnamic aldehyde, linalool, eugenol, camphene cineol, carbohydrate, fat, phosphorus, iron, vitamins A, B1 and B2 have. Cinnamon stimulates the gastrointestinal mucosa, suppresses the gastrointestinal pain of the stomach, promotes the movement of the gastrointestinal tract and improves gastric emptying and digestion and absorption. It also stimulates the nerves to promote blood circulation, warms the body, and suppresses abnormal fermentation of the intestines. Cinnamon extracts are known to have antimicrobial activity such as inhibition of food decay, food preservation effect, and anticancer effects.

The fennel is a dried seed of Aegopodium podagraria, which is spicy, warm in nature, and free from poison. According to Dong-bo-gyung, fennel acts on the liver, the spleen, the kidney, and the stomach, warming the stomach and bladder, controlling the uncomfortable stomach, and eliminating the coldness of the vagina to stop the pain . Also, it stimulates the peristalsis of the intestines, and makes the sluggishness subsided. Recently, the efficacy of fennel for oral inflammation has been reported.

It is a perennial plant belonging to the genus Porphyra, and contains a large amount of active ingredients in roots and leaves. Leaves, roots and stems of jullein contain protein, essential oil, ash organic germanium, and trace elements. It is known that phloem components can improve blood circulation, prevent hair loss and improve hair growth effect, and bathe in water with long hair or improve long-term drinking to improve rheumatoid arthritis. It is known that when human body fluids come into contact with boiled water, unusual microorganisms do not die at 180 ℃. When the water is boiled with this water, the water is boiled, and the skin gets rid of the germs and toxins inside the skin, and the skin becomes stronger, and the skin such as eczema, The disease gets better. Folk remedies have been known to have the effect of alleviating stomatitis in the mouth of the gills.

The cinnamon of the present invention refers to a medicinal substance prepared by drying the bark of bamboo trees, and it is preferable to use roots and leaves of the plant of the present invention.

In addition, the fennel of the present invention was obtained by cultivating and drying the fennel seeds in Yeongcheon City, Gyeongbuk Province.

Hereinafter, a method for preparing a mixed extract of cinnamon, fennel, and fennel according to the present invention will be described in detail.

The method for preparing a mixed extract of cinnamon, fennel and acacia according to the present invention is characterized in that the step (A1) of washing the cinnamon, the fennel and the papaya and air drying for 12 hours and the mixing of the cinnamon, (A3) of preparing a mixed extract by adding an extraction solvent to the mixed powder of the step (A2) and the step (A2) of preparing a mixed powder by grinding, and then extracting with a vacuum extractor and concentrating the mixture with a rotary evaporator .

First, the step (A1) of washing the cinnamon, fennel and gypsum with water and naturally drying for 12 hours is carried out.

Next, the step (A2) of mixing the cinnamon, the fennel and the gypsum of the step (A1) and pulverizing them to prepare a mixed powder is carried out.

Preferably, the cinnamon, fennel, and fennel are contained in an amount of 20 to 40 wt% of cinnamon, 20 to 40 wt% of fennel, and 30 to 60 wt% of fennel, based on the total weight of the mixed powder.

When the content of the cinnamon is less than 20% by weight based on the total weight of the mixed powder, the effect of inhibiting the activity of the causative agent of the causative agent is insignificant because the content is relatively low. When the content exceeds 40% by weight, The feeling of use of the oral composition may be impaired.

When the content of the fennel is less than 20% by weight based on the total weight of the mixed powder, the effect of suppressing and improving the bad breath of the fennel is insignificant because the content is relatively low. When the content is higher than 40% by weight, the content of the fennel is relatively high, The feeling of use of the oral composition may be impaired.

When the content of the phyllotaxin is less than 30% by weight based on the total weight of the mixed powder, the effect of neutralizing the spicy taste of cinnamon and fennel is insignificant and the effect of inhibiting the oral microorganism activity of the phytopathic fungus is insignificant. The content of fennel is relatively lowered, so that the effect of preventing tooth decay and improving bad breath of the oral composition may be deteriorated.

The extraction solvent is added to the mixed powder of the step (A2), extracted with a vacuum extractor, and concentrated to produce a mixed extract (A3).

The extraction solvent may be water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof. Preferably, water and ethanol may be mixed at a weight ratio of 2: 8 and used as an extraction solvent.

The extraction of the step (A2) is carried out using a vacuum extractor at a temperature of 40 to 60 DEG C for 2 to 3 hours. When the extraction temperature is higher than 60 ° C, the fragrance component of the mixed powder can be volatilized. If the extraction temperature is lower than 40 ° C, components of the mixed powder can not be sufficiently extracted, It is preferable to extract at 40 to 60 캜.

It is preferable to extract the mixed powder of cinnamon, fennel, and fructus with an extraction solvent, but it is also possible to use a method of pulverizing, extracting, and then mixing cinnamon, fennel, and fennel.

According to the present invention, the mixed extract may be used in an amount of 0.1 to 10% by weight based on the total weight of the oral composition for preventing tooth decay and improving bad breath. If the content of the mixed extract in the oral composition for preventing tooth decay and bad breath is less than 0.1% by weight, the effect of preventing bad breath and preventing tooth decay is insignificant. If the content is more than 10% by weight, It is insignificant.

The ingredients contained in the oral composition of the present invention may contain, as an active ingredient, an abrasive, a foaming agent, a binder, a humectant, a sweetener, or a pH adjusting agent in addition to a mixed extract of cinnamon, fennel and ginger.

The oral composition comprising the mixed extract of cinnamon, fennel and acacia of the present invention as an active ingredient may be used in the form of dentifrices, oral cleansers, oral cleansers and oral sprays, but is not limited thereto.

As an example, when the oral composition containing the mixed extract of cinnamon, fennel and acacia of the present invention as an active ingredient is a formulation of oral detergent, it may contain ethanol, a wetting agent, a sweetener, and water.

If the content of ethanol is less than 1% by weight based on the total weight of the oral composition of the present invention, the degree of solubilization is significantly lowered. If the amount of ethanol is more than 10% by weight, ethanol content is high and stimulates the oral mucosa, 10% by weight.

The wetting agent may be selected from the group consisting of sorbitol, glycerin, ethylene glycol, propylene glycol, polyether glycol and polypropylene glycol, and may be used in an amount of 1 to 10% by weight based on the total weight of the oral composition.

The sweetener may be selected from the group consisting of sodium saccharin, stevioside, aspartame, xylitol and licorice acid, and may be used in an amount of 0.1 to 5% by weight based on the total weight of the oral composition.

The water may be used in an amount of 65 to 95% by weight based on the total weight of the oral composition.

Hereinafter, the present invention will be described in more detail by way of examples. However, the following examples are provided for illustrative purposes only in order to facilitate understanding of the present invention, and the scope of the present invention is not limited by these examples.

< Example > Cinnamon, fennel and Juliet  Preparation of mixed extracts

(A1) 300g of cinnamon, 300g of fennel, 400g of leaf and root of julienne and dried naturally for 12 hours.

(A2) The cinnamon, fennel, fennel, and roots of step (A1) were mixed and pulverized by a pulverizer to obtain a mixed powder.

(A3) 2000 mL of an extraction solvent in which water and ethanol were mixed at a weight ratio of 2: 8 was added to the mixed powder of the step (A2), and the mixture was extracted with a vacuum extractor at 50 DEG C for 2 to 3 hours, Mixed extracts were prepared.

< Comparative Example  1> Preparation of Cinnamon Extract

(A1) 300 g of cinnamon was washed and dried naturally for 12 hours.

(A2) The cinnamon of the step (A1) was pulverized by a pulverizer to obtain a cinnamon powder.

(A3) 600 mL of an extraction solvent in which water and ethanol were mixed at a weight ratio of 2: 8 was added to the cinnamon powder of the step (A2), and the mixture was extracted with a vacuum extractor at 50 DEG C for 2 to 3 hours, Cinnamon extracts were prepared.

< Comparative Example  2> Fennel extract  Produce

A fennel extract was prepared using 300 g of fennel instead of 300 g of cinnamon of Comparative Example 1.

< Comparative Example  3> Julium extract  Produce

The extract was prepared by using 300 g of leaves and 300 g of roots instead of 300 g of cinnamon of Comparative Example 1.

< Test Example  1> Confirmation of antimicrobial activity

The antimicrobial susceptibility test was conducted to measure the effect of the extracts of the cinnamon, fennel, and fennel extracts of the above examples and the extracts of Comparative Examples 1 to 3 in inhibiting the growth of the causative bacteria of the cucumber, and the MIC and MBC of each bacterium were measured.

Antimicrobial susceptibility tests are used to test the extent to which the causative organism accepts the antimicrobial stimuli and to predict the therapeutic effect of antimicrobial agents on the causative organism. The greater the degree of susceptibility of the antimicrobial agent, the greater the effect of inhibiting the generation of the causative agent. The MIC (Minimum Inhibitory Concentration) refers to the lowest concentration of antimicrobial agent that can inhibit the gross proliferation of cultured bacteria. MBC (Minimal Bactericidal Concentration) refers to the minimum concentration of antimicrobial agent that reduces the amount of pathogenic bacteria (pathogens) by at least 99.9%.

Streptococcus mutans KCTC 3065 (S. mutans), Streptococcus sanguis KCTC 3284 (S. sanguis), and Streptococcus sanguinis KACC 11301 (S. sanguinis) were used as the causative bacteria in Test Example 1 of the present invention. The lyophilized strains were cultured for 24 hours under the culture conditions shown in Table 1 and activated, and then cultured in the same conditions (medium, temperature, time).

Strain Culture conditions Temperature badge Streptococcus mutans KCTC 3065 37 ℃ BHI (Brain Heart Infusion) agar Streptococcus sanguis KCTC 3284 37 ℃ TSB (Tryptic Soy Broth) agar Streptococcus sanguinis KACC 11301 37 ℃ TSB (Tryptic Soy Broth) agar

After the extracts of the examples and comparative examples 1 to 3 were treated for each concentration in a fresh medium, the culture solution of the microorganisms cultured in the above was inoculated and cultured at a temperature of 37 ° C for 24 hours, At 600 nm. The measured values were compared with the absorbance values of the control group (no extract treated group) to determine the MIC.

The culture medium without proliferation on the basis of MIC concentration was diluted in 0.9% NaCl, uniformly plated on the optimal medium, cultured at 37 ° C for 24 hours, and then MBC was measured at a concentration of 99.9% sterilization.

The results of MIC and MBC of the mixed extracts, cinnamon extracts, fennel extracts and gypsum extracts prepared in Examples and Comparative Examples 1 to 3 are shown in Table 2 below.

Example Comparative Example 1 Comparative Example 2 Comparative Example 3 MIC
(Mg / ml) MBC
(Mg / ml) MIC
(Mg / ml) MBC
(Mg / ml) MIC
(Mg / ml) MBC
(Mg / ml) MIC
(Mg / ml) MBC
(Mg / ml) S.mutans 2 4 8 10 15 18 26 30 S.sanguis 2 4 8 11 15 19 25 30 S.sanguinis 2 4 8 11 16 20 28 33

MIC and MBC were measured and the growth of S. mutans, S. sanguis and S. sanguinis was inhibited at 2 mg / ㎖ of the mixed extract of the examples and the bactericidal activity was 99.99% at 4 mg / ㎖. The growth of S. mutans, S. sanguis, and S. sanguinis was suppressed at 8 mg / ml of the cinnamon extract of Comparative Example 1, and 99.99% of S. mutans, S. sanguis, and S. sanguinis at 11 mg / It was sterilized. In the fennel extract of Comparative Example 2, the growth of S. mutans, S. sanguis and S. sanguinis was inhibited at 16 mg / ml, and the concentration of S. mutans, S. sanguis, and S. sanguinis was 99.99% Mg / ml. The growth of S. mutans, S. sanguis, and S. sanguinis was suppressed at 28 mg / ml of the ginseng extract of Comparative Example 3. The concentration of 99.99% of S. mutans, S. sanguis, and S. sanguinis was inhibited by 33 Mg / ml.

Therefore, it can be seen that the mixed extracts of the examples inhibit the growth of S. mutans, S. sanguis, and S. sanguinis at a lower concentration than the cinnamon extract of Comparative Example 1, the fennel extract of Comparative Example 2, . Also, it can be seen that cinnamon, fennel and rosewax enhance the growth inhibition and sterilization effect of S. mutans, S. sanguis, and S. sanguinis by mixing with cinnamon, fennel and rosewort.

< Test Example  2> Inhibition of acid production

In the oral cavity, S. mutans, S. sanguis, and S. sanguinis form the plaque, and then decompose the sugar to lower the pH while producing organic acids. As the pH in the oral cavity is lowered, the enamel of the tooth is deagglomerated and cavities are induced. Therefore, it is necessary to inhibit acid production to prevent tooth decay.

The effect of the mixed extracts of cinnamon, fennel and pine needle on the acid production of S. mutans, S. sanguis and S. sanguinis was investigated. The acid production inhibitory effect was determined by measuring the pH of the culture medium of S. mutans, S. sanguis, and S. sanguinis, respectively.

The strain used in Test Example 2 was the same as the strain used in Test Example 1, and Streptococcus mutans KCTC 3065 (S. mutans), Streptococcus sanguis KCTC 3284 (S. sanguis) and Streptococcus sanguinis KACC 11301 (S. sanguinis) Respectively. The lyophilized strains were cultured for 24 hours under the culture conditions shown in Table 1, activated, and then cultured in the same conditions (medium, temperature, and time).

Each of the cultured S. mutans, S. sanguis, and S. sanguinis cultures was put into a test tube in an amount of 2 ml each, and 1 ml of the mixed extract of the above example prepared by concentration (2, 4, 8 mg / ml) , And the pH was measured after incubation for 4 hours. As a control, 1 ml of a 2% glucose solution was added to 2 ml of each of the S. mutans, S. sanguis, and S. sanguinis cultures, and the pH was measured after incubation for 4 hours. Respectively.

Pre-incubation pH After 4 hours incubation, pH Control group Example By concentration 2 mg / ml 4 mg / ml 8 mg / ml S. mutans 7.20 5.25 7.34 7.41 7.53 S. sanguis 7.05 5.26 7.25 7.38 7.46 S. sanguinis 7.15 5.34 7.53 7.65 7.71

The preincubation pH was 7.20, 7.05, and 7.15, respectively, for the inhibition of acid production of S.mutans, S.sanguis, and S.sanguinis. After 4 hours of incubation, the pH of the control group with the 2% glucose solution was 5.25, 5.26 and 5.34, respectively.

The pH of the S. mutans, S. Sanguis and S. Sanguinis cultured with the mixed extract of the above examples was 7.34, 7.25 and 7.53 when the mixed extract was 2 mg / 7.41, 7.38, and 7.65, respectively, when the concentration was 8 mg / ml, and 7.58, 7.46 and 7.71 when the concentration of the mixed extract was 8 mg / ml.

Therefore, the effect of inhibiting the acid production of the mixed extract of the examples was remarkably higher than that of the control group, and it was found that the effect of inhibiting the acid production of S. mutans, S.sanguis, and S.sanguinis was higher as the concentration of the mixed extract increased .

< Manufacturing example Preparation of oral compositions containing mixed extracts

According to the following Table 3, oral compositions containing different amounts of the mixed extracts of Examples in Production Examples 1 to 5 were prepared, and the extracts of Comparative Examples 1 to 3 or cetylpyridinium chloride in Production Comparative Examples 1 to 4 &Lt; / RTI &gt;

ingredient
(weight%) Production Example 1 Production Example 2 Production Example 3 Production Example 4 Production Example 5 Produce
Comparative Example 1 Produce
Comparative Example 2 Produce
Comparative Example 3 Produce
Comparative Example 4 Example
Mixed extract 0.1 One 5 10 20 Comparative Example 1
Cinnamon extract 10 Comparative Example 2
Fennel extract 10 Comparative Example 3
Julium extract 10 Cetylpyridinium chloride 0.08 ethanol 2 2 2 2 2 2 2 2 2 glycerin 5 5 5 5 5 5 5 5 5 Sackarin
salt 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Purified water 92.8 91.9 87.9 82.9 72.9 82.9 82.9 82.9 82.9 Sum 100 100 100 100 100 100 100 100 100

< Test Example  3> Cinnamon and Creep  Removal of bad breath in oral compositions containing mixed extracts

To determine the effect of the oral compositions prepared in Preparation Examples 1 to 5 on halitosis, 45 adults without oral diseases or other diseases that could affect the experiment were selected. After all the mouthwashes were stopped for 24 hours, the degree of halitosis was measured with a Halimeter, and then the degree of halitosis was measured with a group of five persons having average values similar to each other. The results are shown in Tables 1 to 5 and Comparative Examples 1 to 4 The oral composition was rinsed three times a day for 14 days total. The degree of bad breath was measured with a Harley meter immediately after the experiment, at 7 days, and 14 days, and the reduction effect of the bad breath according to the use period of each oral composition is shown in Table 5 below.

Production Example 1 Production Example 2 Production Example 3 Production Example 4 Production Example 5 Produce
Comparative Example 1 Produce
Comparative Example 2 Produce
Comparative Example 3 Produce
Comparative Example 4 Immediately after the experiment 218 216 219 217 221 222 213 214 214 After 7 days 199 189 178 164 170 194 200 207 178 After 14 days 175 158 146 125 131 178 184 195 142

As shown in Table 5, using the oral compositions of Preparation Examples 1 to 5 and Comparative Preparation Examples 1 to 4, it can be seen that the score of halitosis of the subject significantly decreased as compared with immediately after the experiment.

The oral compositions of Preparation Examples 1 to 4 were found to have a large effect of removing the bad breath as the content of the mixed extract of the examples was increased. On the other hand, in the oral compositions of Production Examples 4 and 5, when the difference in the score of the halitosis was small, and the mixed extract of cinnamon, fennel, and fructus was more than 10% by weight based on the total weight of the oral composition, Is small.

In addition, when the preparation example 4 and the production comparative examples 1 to 3 having the same contents of the extracts were compared, it was found that the oral composition of preparation example 4 had a greater effect of removing the bad breath, and the extract of cinnamon or fennel extract, It can be seen that the oral composition containing the mixed extracts of cinnamon, fennel and paprika is more effective in removing bad breath than the composition.

Comparing the oral composition of Comparative Example 3 containing cetylpyridinium chloride as an active ingredient for removing bad breath to the oral composition of Preparative Examples 3 and 4, it was found that the preparation compositions containing 5% by weight of mixed extracts of cinnamon, 3, and the oral composition containing more than 5% by weight of the mixed extract of cinnamon, fennel, and fructus has a greater effect of removing the bad breath.

Claims (5)

A mixture of cinnamon, fennel and acacia as an active ingredient. The method according to claim 1,
Wherein the mixed extract is contained in an amount of 0.1 to 10% by weight based on the total weight of the oral composition. The method according to claim 1,
Wherein the mixed extract is obtained by extracting a mixed powder of cinnamon, fennel and acacia with an extraction solvent and then concentrating the concentrate. The method of claim 3,
Wherein the extraction solvent is a mixture of water and ethanol at a weight ratio of 2: 8. The method of claim 3,
Wherein the mixed powder contains 20 to 40% by weight of cinnamon, 50 to 40% by weight of cinnamon, 30 to 60% by weight of fennel, and 30 to 60% by weight of a mixture of cinnamon, Composition.