KR20130001989A

KR20130001989A - Mouthwash composition

Info

Publication number: KR20130001989A
Application number: KR1020110062952A
Authority: KR
Inventors: 임성기
Original assignee: (주) 본느
Priority date: 2011-06-28
Filing date: 2011-06-28
Publication date: 2013-01-07

Abstract

The present invention relates to a liquid composition product for oral cavity, and relates to a product of a liquid composition for oral cavity comprising green tea extract, red ginseng extract, red ginseng extract, licorice extract, sugar extract.
Oral composition of the present invention through the role of green tea extract, red ginseng extract, red ginseng extract, licorice extract, the effect of inhibiting the oral bacterial growth of the sugar extracts, bringing the effect of inhibiting bad breath as a product and inhibiting oral bacteria growth more, Unlike the liquid composition for oral cavity has a characteristic that can visually confirm that the coagulation is formed after the gargle.

Description

Mouthwashing agent composition {MOUTHWASH COMPOSITION}

The present invention relates to a liquid composition product for oral cavity, comprising a mixture of green tea extract, red ginseng extract, red ginseng extract, licorice extract, medicinal extract and liquid composition for oral cavity which can visually confirm that the coagulum is formed after goggle It's about the product.

In general, oral odor is generated by the production of malodor-causing substances by decomposing the amino acid generated by microbial decomposition of food or saliva by demineralized enzyme or amino enzyme. The main components of bad breath cause are volatile hydrogen sulfide, methyl mercaptan, amine compound and ammonia.

To date, as a composition showing the bactericidal effect of oral microorganisms, natural ingredients such as extracts of the skin and milky skin are known.

Green Tea is a tea made without fermenting the leaves of tea trees, and the young leaves from the newly sprouted branches are used to make tea, and the leaves are dried and dried three times in May, July, and August. In order to make green tea, the other leaves are immediately heated to destroy oxidase to keep the green color as it is, while the water is evaporated to dry the leaves in a light and dry condition. Tannins in green tea help to soothe and sterilize the skin, and saponin helps to prevent dandruff. In addition, the catechin component is bactericidal.

Red ginseng (Red Ginseng) washes fresh ginseng with water, and steams it for a certain period of time according to its size by using heated steam in a predetermined container. After the first hot air drying, it is dried by using solar heat or by other means until moisture is 12.5 ~ 13.5%. The important components of red ginseng, like white ginseng, contain glycosides, ginseng fragrance (Panacen), polyacetylene compounds, nitrogen-containing components, flavonoids, vitamins, and the like. In addition, red ginseng has sedation and excitability, hematopoietic and anti-inflammatory and anti-tumor action.

Gophora (Sophora Flavescens) is a perennial herb of the dicotyledonous plant Rosaceae, with roots barely peeled. Pharmacological effects have antitumor, antibacterial and immune function inhibitory effects.

Licorice (Glycyrrhiza uralensis fisher) harmonizes the toxicity of all drugs to make the drug appear well, pharmacological action is effective in detoxification, hepatitis, urticaria, dermatitis, eczema.

Glycosides (japanese bitter grass, edamacho, suhwangyeonyeon. Swertia pseudo-chinensis) has the effect of detoxification as an outpost.

Although there have been cases of development in relation to green tea, this is only a report on the antibacterial action through the catechin component of green tea. For the purpose of action and protective action.

The inventors of the present invention are more effective in suppressing oral bad breath and suppressing oral bacterial growth when using green tea extract, red ginseng extract, red ginseng extract, licorice extract, and sugar extract as a component of the oral composition. It has been found that the coagulum is formed and visible confirmation is possible.

Oral liquid composition of the present invention to achieve the above object, green tea extract 0.001 to 0.1% by weight, red ginseng extract 0.001 to 0.1% by weight, high ginseng extract 0.001 to 0.1% by weight, licorice extract 0.001 to 0.1% by weight, sugar extract It contains 0.001 to 0.1% by weight and comprises glycerin and various organic compounds, the remaining amount of purified water.

The composition can expect a more desirable effect when the pH is adjusted to 3.5 to 4.5 range.

Hereinafter, the liquid composition for oral cavity of the present invention will be described in detail.

The liquid composition for oral cavity of the present invention uses green tea extract, red ginseng extract, red ginseng extract, licorice extract, sugar extract as main components.

The liquid composition for oral cavity of the present invention uses green tea extract, red ginseng extract, red ginseng extract, licorice extract, and sugar extract within the range of 0.001 to 0.1 wt%, respectively, if less than this range, the desired cleanliness power is insufficient, If it exceeds this range, it is not preferable because there is a problem such as deposits in the product, irritation of the skin, or coloring of the teeth in the oral cavity.

In addition, in order to suppress bacterial growth and remove bad breath elements at pH, the pH is maintained in a weak acidity range of 3.5 to 4.5. For this, pH regulators such as citric acid and sodium citrate are used. .

In addition, as an oral cleanser, the use of xanthan gum, magnesium aluminum silicate, carbomer, and the like increased the excipient through the chemical polymer to suppress the side effects of skin irritation and intake potential.

For the user's preference of the present invention, a sweetener such as xylitol or polysaccharide may be used, and a visual effect through natural pigment may be possible. In addition, the use of a liquid composition for oral cavity pH is adjusted using a natural pigment that allows the coagulant to be colored and visually confirmed. In consideration of the possibility of fasting and stimulation in the human body, a small amount of natural pigments such as cacao pigment is used.

Since green tea extract, red ginseng extract, red ginseng extract, licorice extract, and sugar extract generally contain natural ingredients that show anti-inflammatory and antibacterial properties, they do not use any single ingredients but have mutual synergistic effects. Was measured.

According to the liquid composition for oral cavity of the present invention as described above, the effect of green tea extract, red ginseng extract, red ginseng extract, licorice extract, sugar extract can be expected to inhibit bad breath and oral bacterial growth, and also according to the composition of the present invention Unlike the liquid composition for oral cavity can be obtained the effect of visually confirm that the coagulation is formed after the gargle.

1 is a photograph showing that the initial bacterial count of the strain cultured in Experimental Example 2 is about 3.7 × 10 ⁵ CFU / ml.
Figure 2 is a photograph showing that the number of bacteria using the composition of the present invention in Experimental Example 2.

Hereinafter, the present invention will be described in detail with reference to Examples, but the present invention is not limited by the following Examples.

Examples 1-4: Preparation of Oral Liquid Composition

Next, a liquid composition for oral cavity was prepared by mixing the compositions shown in Table 1, and green tea extract, red ginseng extract, red ginseng extract, licorice extract, and sugar extract were 5 to 10 wt% of glycerin and 80 to 90 wt% of purified water, respectively. 5-10 wt% of the material (green tea, red ginseng, red ginseng, licorice, medicinal herb) was added and stirred for 1 day at 35 to 40 ° C, and the filtrate was filtered and concentrated under reduced pressure.

division Content (% by weight) Example 1 Example 2 Example 3 Example 4 Green tea extract - 0.001 0.010 0.050 0.100 Red Ginseng Extract - 0.001 0.010 0.050 0.100 Gosam extract - 0.001 0.010 0.050 0.100 Licorice extract - 0.001 0.010 0.050 0.100 Sugar extract - 0.001 0.010 0.050 0.100 Natural pigment Cacao 0.100 0.100 0.100 0.100 Sweetener glycerin 5.000 10.000 15.000 20.000 pH adjusting agent Citric acid 0.300 0.350 0.400 0.450 Purified water - TO 100 TO 100 TO 100 TO 100 synthesis 100 100 100 100 pH 3.70 3.35 3.15 2.98

Experimental Example 1: Clinical comparison experiment on the effects of bad breath

Comparative experiments were performed using the liquid composition for oral cavity prepared with the composition of Table 1 shown in the above example.

1) Subject

Twenty men and women in their twenties and fifties with no dental caries were selected and five subjects were treated per liquid composition for oral cavity.

2) Experiment Method

Refreshment after use was performed according to the preference of the test subjects, and the higher the score, the better the score was.

After use, bad breath is removed from the oral environment by 3 hours after giving the subjects a meal of the same diet. The degree of odor removal was performed according to the subjects' preference by spitting it in the mouth for as long as it was in the mouth, and the higher the score was, the higher the score was. In addition, the amount of coagulant produced after use was measured by visual observation of the resultant spit after 30 minutes to goggle with the liquid composition for the oral cavity 30 minutes after the subject was given a meal of the same diet. The higher the score, the higher the score was.

3) Experiment result

The results of clinical comparison experiments on the bad breath inhibitory effect are shown in Table 2 below.

division Example 1 Example 2 Example 3 Example 4 Sensory test Refreshing after use 4.20 4.00 4.15 3.50 Amount of coagulant produced after use 4.10 4.00 4.15 3.50 Bad breath after use 3.80 3.65 3.70 3.45 synthesis 8.00 7.65 7.85 6.95

As shown in Table 2, the compositions of Examples 1 to 4 were found to be excellent in the freshness and the amount of coagulum produced after use, bad breath removal effect. In particular, as shown in the compositions of Examples 1 and 3, it is confirmed that there is a bad breath removing effect by containing a certain amount of green tea extract, red ginseng extract, red ginseng extract, licorice extract, sugar extract, and the use of pH adjusting agent and sweetener in the composition According to the adjustment according to the change of use, the sensory test showed a difference.

Experimental Example 2: Experiment on Antimicrobial Effects

(1) Antibacterial activity of the liquid composition for oral cavity

Using the liquid composition for oral cavity prepared in the composition of Example 1, the experiment was carried out in the following manner, Streptococcus mutans (Steptococcus mutans) was used as the standard bacteria.

1) Experiment Method

Streptococcus mutans was used as a standard culture, and the method of measuring the bactericidal reduction rate by adding the composition of Example 1 was used, and the initial bacterial count was about 10 ⁵ CFU after culturing the strain at 35 ° C. for 18 hours. / Ml was adjusted to use for the test. After adding the test bacteria solution to 20 ml of the test solution and mixing, the mixture was allowed to stand at room temperature for 30 seconds, 1 minute, and 2 minutes. The reduction rate of sterilization was examined.

Calculation for the sterilization reduction rate was determined according to the equation (1).

[Equation 1]

Sterilization Reduction = [(X-Y) / X] × 100

X: initial bacterial count

Y: Number of bacteria after a certain period

2) Experimental results

Results according to this experiment can be seen according to the culture results for each time after passing as shown in Figures 1 and 2, as shown in Table 3 it can be seen that it has a 99.9% sterilization effect even if left for 30 seconds. there was.

Bacteria Sterilization Reduction Rate Early bacterial count 3.7 × 10 ⁵ CFU / mL - 30 seconds later <10 CFU / mL 99.9% 1 minute later <10 CFU / mL 99.9% 2 minutes later <10 CFU / mL 99.9%

Claims

Oral cleanser composition containing at least one component selected from the group consisting of green tea extract, red ginseng extract, ginseng extract, licorice extract and sugar extract

The method according to claim 1,
The composition is a mouthwash composition further contains an additive.

The method according to claim 2,
The additive is at least one oral cleanser composition selected from the group consisting of sweeteners, pH adjusting agents and natural pigments.

The method according to any one of claims 1 to 3,
The composition contains 0.001 to 0.1% by weight of green tea extract, 0.001 to 0.1% by weight of red ginseng extract, 0.001 to 0.1% by weight of red ginseng extract, 0.001 to 0.1% by weight of licorice extract, 0.001 to 0.1% by weight of sugar extract, and additives 5 to 5. Mouthwash composition comprising 10% by weight and the residual amount of purified water.

The method according to any one of claims 1 to 3,
The composition of claim 1 wherein the pH of the composition ranges from 3.5 to 4.5.