CN108158913B - Sterilizing and deodorizing traditional Chinese medicine toothpaste and preparation method thereof - Google Patents
Sterilizing and deodorizing traditional Chinese medicine toothpaste and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Abstract
The invention relates to a sterilizing and deodorizing traditional Chinese medicine toothpaste and a preparation method thereof, wherein the traditional Chinese medicine toothpaste comprises the following components: 1-2 parts of compound traditional Chinese medicine extract, 0.02-0.05 part of active additive, 20-30 parts of abrasive, 15-20 parts of wetting agent, 7-10 parts of surfactant, 2-3 parts of adhesive and 3-5 parts of spice; the compound traditional Chinese medicine extract comprises 3-5 parts of radix sophorae flavescentis, 0.5-1 part of dried orange peel and 2-3 parts of ash bark according to the weight part of the compound traditional Chinese medicine.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicine daily chemicals, and particularly relates to a sterilizing and deodorizing traditional Chinese medicine toothpaste and a preparation method thereof.
Background
The sophora flavescens is a plant of sophora of leguminosae, and the dried root of the sophora flavescens serves as a traditional Chinese medicine sophora flavescens, is loaded in Shennong Ben Cao Jing of Han Dynasty, is listed as a Chinese medicament, is bitter in taste and cold in nature, has the effects of clearing heat and drying dampness, and killing parasites and promoting urination, has good effects on heat dysentery, hematochezia, anuresis, leucorrhea with reddish discharge, vulva swelling and pruritus, eczema and eczema, and also has good curative effects on external skin pruritus and trichomonas vaginitis. Pericarpium Citri Reticulatae (i.e., pericarpium Citri Reticulatae) derived from mature pericarp of Citrus reticulata and its cultivar of Rutaceae, recorded in Shennong Ben Cao Jing: chen Pi is pungent and warm in flavor. Mainly induce the addiction to heat in the chest, reverse qi, induce diuresis. The ash bark is a commonly used traditional Chinese medicine and is listed as a middle product from Shennong Bencao Jing, and the ash bark is the dry branch bark or dry bark of Fraxinus rhynchophylla Hance, Fraxinus chinensis Roxb, Fraxinus pinnatifida Fraxinus Lingelsh, Fraxinus pinnatifida Lingelsh and Fraxinus chinensis Bengal Lingelsh which are plants of Oleaceae, and is the clinically commonly used traditional Chinese medicine. The traditional Chinese medicine composition has the main effects of clearing heat and drying dampness, relieving asthma and cough and improving eyesight, and is clinically used for treating enteritis, leukorrhagia, chronic bronchitis, bacillary dysentery, conjunctival congestion and swelling pain, epiphora induced by wind, psoriasis and the like. The invention provides a compound traditional Chinese medicine extract of radix sophorae flavescentis, dried orange peel and ash bark, activity of the extract in the aspects of sterilization and deodorization, and application of the extract in the development of preparing oral care products (such as toothpaste).
Disclosure of Invention
The invention provides a compound traditional Chinese medicine extract which is characterized in that the formula of the compound traditional Chinese medicine comprises 3-5 parts of radix sophorae flavescentis, 0.5-1 part of dried orange peel and 2-3 parts of ash bark in parts by weight.
The compound traditional Chinese medicine extract is characterized in that the formula of the compound traditional Chinese medicine is preferably 3 parts by weight of radix sophorae flavescentis, 0.5 part by weight of dried orange peel and 2 parts by weight of ash bark.
Another embodiment of the present invention provides the above compound herbal extract, characterized in that the preparation method of the compound herbal extract comprises the following steps:
(1) weighing dried radix Sophorae Flavescentis, pericarpium Citri Tangerinae and cortex Fraxini according to formula, pulverizing, adding water, appropriate amount of cellulase and papain, mixing, adjusting pH to 5.5-6.5, fermenting at 30-40 deg.C for 2-3 days, filtering to obtain fermentation broth, and concentrating the fermentation broth to obtain fermented product;
(2) adsorbing the fermentation product obtained in the step (1) by using macroporous resin, eluting by using 30-40% ethanol solution in volume fraction, collecting eluent with 3-5 times of column volume, decoloring by using active carbon, concentrating and drying to obtain the compound traditional Chinese medicine extract.
Preferably, distilled water or deionized water is selected as water in the step (1), the mass amount of the water is 5-8 times of the mass sum of the sophora flavescens, the pericarpium citri reticulatae and the ash bark, the mass amount of the cellulase is 0.5-1.0% of the mass sum of the sophora flavescens, the pericarpium citri reticulatae and the ash bark, and the mass ratio of the papain to the cellulase is 1: 1;
the model of the macroporous resin in the step (2) is selected from one of AB-8, D101, HZ818 and HPD 100.
Another embodiment of the present invention provides a method for preparing the compound traditional Chinese medicine extract, which is characterized by comprising the following steps:
(1) weighing dried radix Sophorae Flavescentis, pericarpium Citri Tangerinae and cortex Fraxini according to formula, pulverizing, adding water, appropriate amount of cellulase and papain, mixing, adjusting pH to 5.5-6.5, fermenting at 30-40 deg.C for 2-3 days, filtering to obtain fermentation broth, and concentrating the fermentation broth to obtain fermented product;
(2) adsorbing the fermentation product obtained in the step (1) by using macroporous resin, eluting by using 30-40% ethanol solution in volume fraction, collecting eluent with 3-5 times of column volume, decoloring by using active carbon, concentrating and drying to obtain the compound traditional Chinese medicine extract.
Preferably, distilled water or deionized water is selected as water in the step (1), the mass amount of the water is 5-8 times of the mass sum of the sophora flavescens, the pericarpium citri reticulatae and the ash bark, the mass amount of the cellulase is 0.5-1.0% of the mass sum of the sophora flavescens, the pericarpium citri reticulatae and the ash bark, and the mass ratio of the papain to the cellulase is 1: 1;
the model of the macroporous resin in the step (2) is selected from one of AB-8, D101, HZ818 and HPD 100.
The other embodiment of the invention provides application of the compound traditional Chinese medicine extract as an antibacterial agent.
The other embodiment of the invention provides application of the compound traditional Chinese medicine extract in preparing a medicine for preventing and/or treating diseases caused by bacterial infection. The bacterium is preferably Escherichia coli or Staphylococcus aureus.
Another embodiment of the invention provides an application of the compound traditional Chinese medicine extract in preparing an oral care product. The oral care product is preferably a breath freshener, toothpaste, lipstick, mouthwash, or the like.
Another embodiment of the invention provides application of the compound traditional Chinese medicine extract in removing volatile sulfides. The volatile sulfide is preferably one or more of dimethyl sulfide, hydrogen sulfide and methyl mercaptan.
Another embodiment of the invention provides an oral care product, which is characterized in that the oral care product comprises the compound traditional Chinese medicine extract. The oral care product is preferably a breath freshener, toothpaste, lipstick, mouthwash, or the like.
Another embodiment of the present invention provides a bactericidal and deodorant traditional Chinese medicine toothpaste, which is characterized in that the traditional Chinese medicine toothpaste comprises the following components:
1-2 parts of the compound traditional Chinese medicine extract, 0.02-0.05 part of active additive, 20-30 parts of abrasive, 15-20 parts of wetting agent, 7-10 parts of surfactant, 2-3 parts of adhesive and 3-5 parts of spice.
The active additive is selected from chlorophyll or sodium fluoride, the abrasive is selected from one or more of calcium carbonate, calcium hydrophosphate, silicon dioxide and alumina trihydrate, the wetting agent is selected from one or more of water, glycerin and sorbitol, the surfactant is selected from one or more of sodium dodecyl sulfate, sodium lauroyl sarcosinate, sodium phenolglutamate and cocamidopropyl betaine, the adhesive is selected from one or more of xanthan gum, sodium alginate, hydroxyethyl cellulose, guar gum, sodium carboxymethylcellulose and carrageenan, and the perfume is selected from one or more of peppermint oil, menthol and mugwort leaf essence.
Another embodiment of the present invention provides a method for preparing the above bactericidal and deodorant traditional Chinese medicine toothpaste, which is characterized by comprising the following steps:
weighing 1-2 parts of the compound traditional Chinese medicine extract, 0.02-0.05 part of active additive, 7-10 parts of surfactant and 15-20 parts of wetting agent according to parts by weight, stirring to form a mixed solution, adding 20-30 parts of abrasive, 2-3 parts of adhesive and 3-5 parts of spice according to parts by weight, stirring and grinding for 0.5-1 hour, degassing in vacuum to prepare paste, and packaging to obtain the sterilizing and deodorizing traditional Chinese medicine toothpaste.
The active additive is selected from chlorophyll or sodium fluoride, the abrasive is selected from one or more of calcium carbonate, calcium hydrophosphate, silicon dioxide and alumina trihydrate, the wetting agent is selected from one or more of water, glycerin and sorbitol, the surfactant is selected from one or more of sodium dodecyl sulfate, sodium lauroyl sarcosinate, sodium phenolglutamate and cocamidopropyl betaine, the adhesive is selected from one or more of xanthan gum, sodium alginate, hydroxyethyl cellulose, guar gum, sodium carboxymethylcellulose and carrageenan, and the perfume is selected from one or more of peppermint oil, menthol and mugwort leaf essence.
The preparation method of the compound traditional Chinese medicine extract comprises the following steps:
(1) weighing dried radix Sophorae Flavescentis, pericarpium Citri Tangerinae and cortex Fraxini according to formula, pulverizing, adding water, appropriate amount of cellulase and papain, mixing, adjusting pH to 5.5-6.5, fermenting at 30-40 deg.C for 2-3 days, filtering to obtain fermentation broth, and concentrating the fermentation broth to obtain fermented product;
(2) adsorbing the fermentation product obtained in the step (1) by using macroporous resin, eluting by using 30-40% ethanol solution in volume fraction, collecting eluent with 3-5 times of column volume, decoloring by using active carbon, concentrating and drying to obtain the compound traditional Chinese medicine extract.
Preferably, distilled water or deionized water is selected as water in the step (1), the mass amount of the water is 5-8 times of the mass sum of the sophora flavescens, the pericarpium citri reticulatae and the ash bark, the mass amount of the cellulase is 0.5-1.0% of the mass sum of the sophora flavescens, the pericarpium citri reticulatae and the ash bark, and the mass ratio of the papain to the cellulase is 1: 1;
the model of the macroporous resin in the step (2) is selected from one of AB-8, D101, HZ818 and HPD 100.
The sterilizing and deodorizing traditional Chinese medicine toothpaste is applied to removing volatile sulfides. The volatile sulfide is preferably one or more of dimethyl sulfide, hydrogen sulfide and methyl mercaptan.
The kuh-seng, the dried orange peel and the ash bark can be Chinese medicinal materials or Chinese medicinal decoction pieces.
Compared with the prior art, the invention has the advantages that: (1) the invention provides a fermented extract of three compound traditional Chinese medicines of radix sophorae flavescentis, pericarpium citri reticulatae and ash bark, which has excellent characteristics in the aspects of resisting bacteria and removing volatile sulfides; (2) the invention relates to a sterilization and deodorization toothpaste prepared by using a compound traditional Chinese medicine fermentation extract.
Detailed Description
In order to facilitate a further understanding of the invention, the following examples are provided to illustrate it in more detail. However, these examples are only for better understanding of the present invention and are not intended to limit the scope or the principle of the present invention, and the embodiments of the present invention are not limited to the following.
Example 1
(1) Pulverizing dried radix Sophorae Flavescentis 300g, pericarpium Citri Tangerinae 50g, and cortex Fraxini 200g, adding distilled water (2.75kg), cellulase 2.75g and papain 2.75g, mixing, adjusting pH to 5.5-6.0, fermenting at 30 deg.C for 3 days, filtering to obtain fermentation liquid, and concentrating to obtain fermented product;
(2) adsorbing the fermentation product obtained in the step (1) by AB-8 type macroporous resin, eluting by using 40% ethanol solution in volume fraction, collecting eluent with 3 times of column volume, decoloring by using active carbon, concentrating and drying to obtain the compound traditional Chinese medicine extract (7.6g, hereinafter referred to as product A).
Example 2
(1) Pulverizing dried radix Sophorae Flavescentis 500g, pericarpium Citri Tangerinae 100g, and cortex Fraxini 300g, adding deionized water (7.2kg), cellulase 9g and papain 9g, mixing, adjusting pH to 6.0-6.5, fermenting at 40 deg.C for 2 days, filtering to obtain fermentation broth, and concentrating the fermentation broth to obtain fermented product;
(2) adsorbing the fermentation product obtained in the step (1) by using D101 type macroporous resin, eluting by using 30% ethanol solution in volume fraction, collecting eluent with 5 times of column volume, decoloring by using active carbon, concentrating and drying to obtain the compound traditional Chinese medicine extract (12.8g, hereinafter referred to as a product B).
Example 3
(1) Pulverizing dried radix Sophorae Flavescentis 500g, pericarpium Citri Tangerinae 50g, and cortex Fraxini 200g, adding distilled water (4.5kg), cellulase 4.5g and papain 4.5g, mixing, adjusting pH to 5.5-6.0, fermenting at 35 deg.C for 2.5 days, filtering to obtain fermentation liquid, and concentrating the fermentation liquid to obtain fermented product;
(2) adsorbing the fermentation product obtained in the step (1) by using HPD100 type macroporous resin, eluting by using 35% ethanol solution in volume fraction, collecting eluent with 4 times of column volume, decoloring by using active carbon, concentrating and drying to obtain the compound traditional Chinese medicine extract (10.4g, hereinafter referred to as product C).
Example 4
(1) Pulverizing dried radix Sophorae Flavescentis 300g and pericarpium Citri Tangerinae 50g, adding distilled water (2.75kg), cellulase 2.75g and papain 2.75g, mixing, adjusting pH to 5.5-6.0, fermenting at 30 deg.C for 3 days, filtering to obtain fermentation broth, and concentrating the fermentation broth to obtain fermented product;
(2) adsorbing the fermentation product obtained in the step (1) by AB-8 type macroporous resin, eluting by using 40% ethanol solution in volume fraction, collecting eluent with 3 times of column volume, decoloring by using active carbon, concentrating and drying to obtain the compound traditional Chinese medicine extract (3.2g, hereinafter referred to as product D).
Example 5
(1) Pulverizing dried pericarpium Citri Tangerinae 50g and cortex Fraxini 200g, adding distilled water (2.75kg), cellulase 2.75g and papain 2.75g, mixing, adjusting pH to 5.5-6.0, fermenting at 30 deg.C for 3 days, filtering to obtain fermentation broth, and concentrating the fermentation broth to obtain fermented product;
(2) adsorbing the fermentation product obtained in the step (1) by AB-8 type macroporous resin, eluting by using 40% ethanol solution in volume fraction, collecting eluent with 3 times of column volume, decoloring by using active carbon, concentrating and drying to obtain the compound traditional Chinese medicine extract (2.1g, hereinafter referred to as a product E).
Example 6
(1) Pulverizing dried radix Sophorae Flavescentis 300g and cortex Fraxini 200g, adding distilled water (2.75kg), cellulase 2.75g and papain 2.75g, mixing, adjusting pH to 5.5-6.0, fermenting at 30 deg.C for 3 days, filtering to obtain fermentation broth, and concentrating the fermentation broth to obtain fermented product;
(2) adsorbing the fermentation product obtained in the step (1) by AB-8 type macroporous resin, eluting by using 40% ethanol solution in volume fraction, collecting eluent with 3 times of column volume, decoloring by using active carbon, concentrating and drying to obtain the compound traditional Chinese medicine extract (5.4g, hereinafter referred to as product F).
Example 7
(1) Pulverizing dried radix Sophorae Flavescentis 300g, pericarpium Citri Tangerinae 10g, and cortex Fraxini 200g, adding distilled water (2.75kg), cellulase 2.75g and papain 2.75g, mixing, adjusting pH to 5.5-6.0, fermenting at 30 deg.C for 3 days, filtering to obtain fermentation liquid, and concentrating to obtain fermented product;
(2) adsorbing the fermentation product obtained in the step (1) by AB-8 type macroporous resin, eluting by using 40% ethanol solution in volume fraction, collecting eluent with 3 times of column volume, decoloring by using active carbon, concentrating, and drying to obtain the compound traditional Chinese medicine extract (6.2G, hereinafter referred to as product G).
Example 8
Taking 300g of dried radix sophorae flavescentis, 50g of dried tangerine peel and 200g of ash bark, crushing the dried radix sophorae flavescentis, 50g of dried tangerine peel and 200g of ash bark, adding distilled water (2.75kg) into the mixture, uniformly mixing the mixture, adjusting the pH value to 5.5-6.0, soaking the mixture for 3 days at the temperature of 30 ℃, filtering the mixture to obtain filtrate, concentrating the filtrate, adsorbing the concentrated filtrate by AB-8 type macroporous resin, eluting the filtrate by using 40 volume percent ethanol solution, collecting eluent with the volume of 3 times of the column volume, decoloring, concentrating and drying the eluent by using active carbon to obtain the compound traditional Chinese medicine extract (4.6g, hereinafter.
Example 9 antimicrobial Activity test
Products A-H are respectively prepared into 50 mu g/mL solutions, and the bacteriostatic activity of the solutions on Escherichia coli E.coli ATCCC 25922 and Staphylococcus aureus S.aureus ATCC25923 is tested by a bacteriostatic circle method. The results are shown in Table 1.
TABLE 1
| Test sample | E.coli ATCC25922(mm) | S.aureus ATCC25923(mm) |
| Product A | 20.2 | 23.5 |
| Product B | 19.3 | 22.6 |
| Product C | 19.5 | 23.0 |
| Product D | 16.8 | 17.2 |
| Product E | 13.6 | 13.5 |
| Product F | 17.0 | 17.2 |
| Product G | 17.7 | 19.3 |
| Product H | 16.3 | 16.9 |
Note: the data in the table show the diameter of the zone of inhibition (diameter of the filter paper sheet 12.80mm)
EXAMPLE 10 products A-H p-dimethyl sulfide (Me)2S) cleaning experiment
450mL of 1% dimethyl sulfide solution was prepared with absolute ethanol, 9 parts (50 mL each) were divided, 3mg of each of the products A to H was added to 8 parts of the solution, the 9 th part of the solution was reacted at 37 ℃ for 1 hour without any sample as a control, and the content of dimethyl sulfide was measured by gas chromatography-mass spectrometry (GC-MS), and the results are shown in Table 2.
TABLE 2
| Numbering | Adding the sample | Content of dimethyl sulfide |
| 1 | Product A | 0.26％ |
| 2 | Product B | 0.30％ |
| 3 | Product C | 0.29％ |
| 4 | Product D | 0.76％ |
| 5 | Product E | 0.80％ |
| 6 | Product F | 0.92％ |
| 7 | Product G | 0.62％ |
| 8 | Product H | 0.82％ |
| 9 | Is free of | 0.96％ |
Example 11
Weighing 1 part of product A, 0.02 part of sodium fluoride, 7 parts of sodium dodecyl sulfate, 5 parts of sorbitol and 10 parts of water according to the parts by weight, stirring to form a mixed solution, adding 20 parts of calcium carbonate, 2 parts of sodium carboxymethyl cellulose and 3 parts of peppermint oil according to the parts by weight, stirring and grinding for 0.5 hour, vacuum degassing to prepare paste, storing the paste, and packaging to obtain the sterilizing and deodorizing traditional Chinese medicine toothpaste.
Example 12
Weighing 2 parts of product B, 0.05 part of chlorophyll, 10 parts of sodium lauroyl sarcosinate, 5 parts of sorbitol and 15 parts of water according to the parts by weight, stirring to form a mixed solution, adding 20 parts of calcium carbonate, 10 parts of silicon dioxide, 1 part of xanthan gum, 1 part of sodium alginate, 2 parts of menthol and 3 parts of folium artemisiae argyi essence according to the parts by weight, stirring and grinding for 1.0 hour, vacuum degassing to prepare paste, storing the paste, and packaging to obtain the sterilizing and deodorizing traditional Chinese medicine toothpaste.
Example 13
Weighing 1 part of product C, 0.03 part of sodium fluoride, 8 parts of sodium phenolglutamate, 8 parts of glycerol and 10 parts of water according to the parts by weight, stirring to form a mixed solution, adding 20 parts of calcium carbonate, 2 parts of alumina trihydrate, 2.5 parts of carrageenan, 2 parts of peppermint oil and 2 parts of menthol according to the parts by weight, stirring and grinding for 45 minutes, vacuum degassing to prepare paste, (storing the paste, filling) and packaging to obtain the sterilizing and deodorizing traditional Chinese medicine toothpaste.
The parts by weight in examples 11 to 13 represent 10g each.
Claims (3)
1. The application of the sterilizing and deodorizing traditional Chinese medicine toothpaste in removing dimethyl sulfide is characterized in that the traditional Chinese medicine toothpaste comprises the following components:
1-2 parts of compound traditional Chinese medicine extract, 0.02-0.05 part of active additive, 20-30 parts of abrasive, 15-20 parts of wetting agent, 7-10 parts of surfactant, 2-3 parts of adhesive and 3-5 parts of spice;
the compound traditional Chinese medicine extract comprises 3-5 parts of radix sophorae flavescentis, 0.5-1 part of dried orange peel and 2-3 parts of ash bark by weight;
the preparation method of the compound traditional Chinese medicine extract comprises the following steps:
(1) weighing dried radix Sophorae Flavescentis, pericarpium Citri Tangerinae and cortex Fraxini according to formula, pulverizing, adding water, appropriate amount of cellulase and papain, mixing, adjusting pH to 5.5-6.5, fermenting at 30-40 deg.C for 2-3 days, filtering to obtain fermentation broth, and concentrating the fermentation broth to obtain fermented product;
(2) adsorbing the fermentation product obtained in the step (1) by using macroporous resin, eluting by using 30-40% ethanol solution in volume fraction, collecting eluent with the volume of 3-5 times of that of the column, decoloring by using active carbon, concentrating and drying to obtain the compound traditional Chinese medicine extract;
the water in the step (1) is selected from distilled water or deionized water, the mass amount of the water is 5-8 times of the mass sum of the sophora flavescens, the pericarpium citri reticulatae and the ash bark, the mass amount of the cellulase is 0.5-1.0% of the mass sum of the sophora flavescens, the pericarpium citri reticulatae and the ash bark, and the mass ratio of the papain to the cellulase is 1: 1.
2. The use according to claim 1, characterized in that the active additive is selected from chlorophyll or sodium fluoride, the abrasive is selected from one or more of calcium carbonate, calcium hydrogen phosphate, silicon dioxide, alumina trihydrate, the humectant is selected from one or more of water, glycerol, and sorbitol, the surfactant is selected from one or more of sodium dodecyl sulfate, sodium lauroyl sarcosinate, and cocamidopropyl betaine, the binder is selected from one or more of xanthan gum, sodium alginate, hydroxyethyl cellulose, guar gum, sodium carboxymethyl cellulose, and carrageenan, and the flavor is selected from one or more of peppermint oil, menthol, and mugwort leaf essence.
3. The use of claim 1, characterized in that the preparation method of the sterilizing and deodorizing traditional Chinese medicine toothpaste comprises the following steps:
weighing 1-2 parts of the compound traditional Chinese medicine extract, 0.02-0.05 part of active additive, 7-10 parts of surfactant and 15-20 parts of wetting agent according to parts by weight, stirring to form a mixed solution, adding 20-30 parts of abrasive, 2-3 parts of adhesive and 3-5 parts of spice according to parts by weight, stirring and grinding for 0.5-1 hour, degassing in vacuum to prepare paste, and packaging to obtain the sterilizing and deodorizing traditional Chinese medicine toothpaste.
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| CN109381385A (en) * | 2018-09-07 | 2019-02-26 | 南京医科大学附属口腔医院 | A kind of auxiliary ultrasonic, which cleans one's teeth, dispels tartar oral care composition, preparation method and application |
| CN108852953A (en) * | 2018-09-28 | 2018-11-23 | 广东温和堂健康科学有限公司 | A kind of formula and technique of Xinhui citrus reticulata unshiu peel extract production toothpaste |
| CN110368327A (en) * | 2019-08-14 | 2019-10-25 | 广州益凡医疗器械有限公司 | A kind of plaque removes gel and preparation method thereof |
| CN113384487A (en) * | 2021-06-30 | 2021-09-14 | 广州名大实业有限公司 | Formula of toothpaste capable of efficiently removing smoke spots |
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|---|---|---|---|---|
| KR20130001989A (en) * | 2011-06-28 | 2013-01-07 | (주) 본느 | Mouthwash composition |
| CN105748385A (en) * | 2016-02-25 | 2016-07-13 | 安徽万春日化有限公司 | Toothpaste for improving gingival blood circulation, and maintaining periodontal and oral mucosa health |
| CN107007502A (en) * | 2017-04-18 | 2017-08-04 | 新疆中草堂医药科技有限公司 | The oral care composition of noresidue sense |
-
2018
- 2018-03-20 CN CN201810233480.4A patent/CN108158913B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130001989A (en) * | 2011-06-28 | 2013-01-07 | (주) 본느 | Mouthwash composition |
| CN105748385A (en) * | 2016-02-25 | 2016-07-13 | 安徽万春日化有限公司 | Toothpaste for improving gingival blood circulation, and maintaining periodontal and oral mucosa health |
| CN107007502A (en) * | 2017-04-18 | 2017-08-04 | 新疆中草堂医药科技有限公司 | The oral care composition of noresidue sense |
Non-Patent Citations (2)
| Title |
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| "16种中药及其组方对临床常见致病菌的抑菌作用探讨";袁心红;《中国中医药咨讯》;20120228;第4卷(第2期);第235页表1 * |
| "秦皮提取物抑菌活性及稳定性研究";张霞 等;《安徽农业科学》;20100531;第38卷(第5期);第2358页摘要 * |
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| CN108158913A (en) | 2018-06-15 |
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