CN108158913A - A kind of deodorization and sterilization Chinese medicinal toothpaste and preparation method thereof - Google Patents
A kind of deodorization and sterilization Chinese medicinal toothpaste and preparation method thereof Download PDFInfo
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- CN108158913A CN108158913A CN201810233480.4A CN201810233480A CN108158913A CN 108158913 A CN108158913 A CN 108158913A CN 201810233480 A CN201810233480 A CN 201810233480A CN 108158913 A CN108158913 A CN 108158913A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Abstract
The present invention relates to a kind of deodorization and sterilization Chinese medicinal toothpaste and preparation method thereof, the Chinese medicinal toothpaste includes following ingredient：12 parts of compound Chinese medicine extract, active 0.02 0.05 parts of additive, 20 30 parts of rubbing agent, 15 20 parts of wetting agent, 7 10 parts of surfactant, 23 parts of adhesive, 35 parts of fragrance；The formula of the compound Chinese medicine extract, by weight herbal mixture is 35 parts of kuh-seng, 0.5 1 parts of dried orange peel, 23 parts of the bark of ash.
Description
Technical field
The invention belongs to Chinese medicine chemical product fields, and in particular to a kind of deodorization and sterilization Chinese medicinal toothpaste and preparation method thereof.
Background technology
Kuh-seng is cassia leguminous plant, and dry root is used as medicine as traditional Chinese medicine kuh-seng, first recorded in Han dynasty《Legendary god of farming's book on Chinese herbal medicine
Through》, be classified as middle product, bitter is cold in nature, has heat-clearing and damp-drying drug, the effect of desinsection diuresis, to hot dysentery, have blood in stool, renal shutdown, leukorrhea with reddish discharge,
Swelling of vulva pruritus vulvae, eczema, wet sore have good action, and external skin itch, trichomonas vaginitis also have the effect of fine.Dried orange peel is (i.e.
Orange peel), from rutaceae orange and its ripe pericarp of variety,《Sheng Nong's herbal classic》It says：Dried orange peel, acrid flavour, temperature.It is main
Addiction heat in the heart, inverse gas, sharp trough.The bark of ash is conventional Chinese medicine, first recorded in《Sheng Nong's herbal classic》, middle product are classified as,《Chinese Pharmacopoeia》
The version regulation bark of ash in 2015 is Oleaceae plants fraxinus rhynchophylla Hance Fraxinus rhynchophylla Hance, Chinese ash
Fraxinus chinensis Roxb., sharp leaf Chinese ash Fraxinusszaboana Lingelsh., place column Chinese ash
The drying branch skin or dry hide of Fraxinus stylosaLingelsh. is clinical conventional Chinese medicine.Its primary efficacy is dry for heat-clearing
Wet, antiasthmatic-antitussive, improving eyesight are clinically swollen for treating enteritis, leukorrhea, chronic bronchitis, bacillary dysentery, hot eyes
Bitterly, tearing against wind, psoriasis etc..The present invention provides that a kind of kuh-seng, dried orange peel, bark of ash compound Chinese medicine extract, it is in sterilization, deodorization
The activity of aspect and exploitation are used to prepare the purposes of oral care product (such as toothpaste).
Invention content
The present invention provides a kind of compound Chinese medicine extract, it is characterised in that the formula of herbal mixture described by weight is
3-5 parts of kuh-seng, 0.5-1 parts of dried orange peel, 2-3 parts of the bark of ash.
Above-mentioned compound Chinese medicine extract, it is characterised in that the formula of herbal mixture described by weight is preferably kuh-seng 3
Part, 0.5 part of dried orange peel, 2 parts of the bark of ash.
Another embodiment of the present invention provides above-mentioned compound Chinese medicine extract, it is characterised in that the herbal mixture extraction
The preparation method of object, includes the following steps：
(1) dry kuh-seng, dried orange peel, the bark of ash are measured by formula, after being crushed, add in water, suitable cellulase and
Papain mixing adjusts pH5.5-6.5, at 30-40 DEG C, ferments 2-3 days, filters to obtain zymotic fluid, zymotic fluid is concentrated to give hair
Ferment object；
(2) fermentate that step (1) obtains passes through macroporous resin adsorption, the ethanol solution for being 30-40% with volume fraction
Elution collects 3-5 times of column volume eluent, then through activated carbon decolorizing, concentration, dry the compound Chinese medicine extract.
The preferred distilled water of water or deionized water in step (1), the quality dosage of water is kuh-seng, dried orange peel, bark of ash quality sum
5-8 times, the quality dosage of cellulase is kuh-seng, the 0.5-1.0% of dried orange peel, bark of ash quality sum, papain with it is fine
The mass ratio of the plain enzyme of dimension is 1:1；
The one kind of the model of step (2) described macroreticular resin in AB-8, D101, HZ818, HPD100.
Another embodiment of the present invention provides the preparation method of above-mentioned compound Chinese medicine extract, it is characterised in that including such as
Lower step：
(1) dry kuh-seng, dried orange peel, the bark of ash are measured by formula, after being crushed, add in water, suitable cellulase and
Papain mixing adjusts pH5.5-6.5, at 30-40 DEG C, ferments 2-3 days, filters to obtain zymotic fluid, zymotic fluid is concentrated to give hair
Ferment object；
(2) fermentate that step (1) obtains passes through macroporous resin adsorption, the ethanol solution for being 30-40% with volume fraction
Elution collects 3-5 times of column volume eluent, then through activated carbon decolorizing, concentration, dry the compound Chinese medicine extract.
The preferred distilled water of water or deionized water in step (1), the quality dosage of water is kuh-seng, dried orange peel, bark of ash quality sum
5-8 times, the quality dosage of cellulase is kuh-seng, the 0.5-1.0% of dried orange peel, bark of ash quality sum, papain with it is fine
The mass ratio of the plain enzyme of dimension is 1:1；
The one kind of the model of step (2) described macroreticular resin in AB-8, D101, HZ818, HPD100.
Another embodiment of the present invention provides application of the above-mentioned compound Chinese medicine extract as antiseptic.
Another embodiment of the present invention provides above-mentioned compound Chinese medicine extract and is preparing prevention and/or treatment bacterium infection
Cause the application in the drug of disease.The preferred Escherichia coli of the bacterium or staphylococcus aureus.
Another embodiment of the present invention provides application of the above-mentioned compound Chinese medicine extract in oral care product is prepared.
The preferred flavorants of the oral care product, toothpaste, lipstick, mouthwash etc..
Another embodiment of the present invention provides application of the above-mentioned compound Chinese medicine extract in volatile sulfur compounds are removed.
One or more of the preferred dimethyl sulfide of the volatile sulfur compounds, hydrogen sulfide, methyl mercaptan.
Another embodiment of the present invention provides a kind of oral care product, it is characterised in that the oral care product includes
Above-mentioned compound Chinese medicine extract.The preferred flavorants of the oral care product, toothpaste, lipstick, mouthwash etc..
Another embodiment of the present invention provides a kind of deodorization and sterilization Chinese medicinal toothpaste, it is characterised in that the Chinese medicinal toothpaste packet
Containing following ingredient：
Above-mentioned compound Chinese medicine extract 1-2 parts, active 0.02-0.05 parts of additive, 20-30 parts of rubbing agent, wetting agent 15-
20 parts, 7-10 parts of surfactant, 2-3 parts of adhesive, 3-5 parts of fragrance.
It is described activity additive be selected from chlorophyll or sodium fluoride, rubbing agent be selected from calcium carbonate, calcium monohydrogen phosphate, silica,
One or more of hibbsite, wetting agent are selected from one or more of water, glycerine, sorbierite, surfactant
One kind or several in lauryl sodium sulfate, sodium lauroyl sarcosine, phenolic group sodium glutamate, Cocoamidopropyl betaine
Kind, adhesive in xanthans, extra large bath acid sodium, hydroxyethyl cellulose, guar gum, sodium carboxymethylcellulose, carragheen one
Kind is several, and fragrance is selected from one or more of peppermint oil, menthol, folium artemisiae argyi essence.
Another embodiment of the present invention provides the preparation method of above-mentioned deodorization and sterilization Chinese medicinal toothpaste, it is characterised in that including
Following steps：
According to parts by weight weigh above-mentioned compound Chinese medicine extract 1-2 parts, active 0.02-0.05 parts of additive, surface-active
15-20 parts of 7-10 parts of agent, wetting agent stirrings form mixed solution, and 20-30 parts of rubbing agent, adhesive 2- are added in according still further to parts by weight
3 parts, 3-5 parts of fragrance, agitation grinding 0.5-1 hours, vacuum outgas cream are packed up to the deodorization and sterilization Chinese medicinal toothpaste.
It is described activity additive be selected from chlorophyll or sodium fluoride, rubbing agent be selected from calcium carbonate, calcium monohydrogen phosphate, silica,
One or more of hibbsite, wetting agent are selected from one or more of water, glycerine, sorbierite, surfactant
One kind or several in lauryl sodium sulfate, sodium lauroyl sarcosine, phenolic group sodium glutamate, Cocoamidopropyl betaine
Kind, adhesive in xanthans, extra large bath acid sodium, hydroxyethyl cellulose, guar gum, sodium carboxymethylcellulose, carragheen one
Kind is several, and fragrance is selected from one or more of peppermint oil, menthol, folium artemisiae argyi essence.
The preparation method of the compound Chinese medicine extract, includes the following steps：
(1) dry kuh-seng, dried orange peel, the bark of ash are measured by formula, after being crushed, add in water, suitable cellulase and
Papain mixing adjusts pH5.5-6.5, at 30-40 DEG C, ferments 2-3 days, filters to obtain zymotic fluid, zymotic fluid is concentrated to give hair
Ferment object；
(2) fermentate that step (1) obtains passes through macroporous resin adsorption, the ethanol solution for being 30-40% with volume fraction
Elution collects 3-5 times of column volume eluent, then through activated carbon decolorizing, concentration, dry the compound Chinese medicine extract.
The preferred distilled water of water or deionized water in step (1), the quality dosage of water is kuh-seng, dried orange peel, bark of ash quality sum
5-8 times, the quality dosage of cellulase is kuh-seng, the 0.5-1.0% of dried orange peel, bark of ash quality sum, papain with it is fine
The mass ratio of the plain enzyme of dimension is 1:1；
The one kind of the model of step (2) described macroreticular resin in AB-8, D101, HZ818, HPD100.
Application of the deodorization and sterilization Chinese medicinal toothpaste in volatile sulfur compounds are removed.The volatile sulfur compounds preferably two
One or more of Dimethyl sulfide, hydrogen sulfide, methyl mercaptan.
Kuh-seng of the present invention, dried orange peel, the bark of ash can be Chinese medicine or the prepared slices of Chinese crude drugs.
Compared with prior art, the advantage of the invention is that：(1) present invention provides a kind of kuh-seng, dried orange peel, three taste of the bark of ash and answers
Square herb fermenting extract, the extract show excellent characteristic in terms of antibacterial, removing volatile sulfur compounds；(2) this hair
It is bright to prepare a kind of deodorization and sterilization toothpaste using herbal mixture extractive from fermentative.
Specific embodiment
For the ease of a further understanding of the present invention, examples provided below has done more detailed description to it.But
It is that these embodiments only are not used for limiting the scope of the present invention or implementation principle, reality of the invention for being better understood from inventing
The mode of applying is not limited to the following contents.
Embodiment 1
(1) dry kuh-seng 300g, dried orange peel 50g, bark of ash 200g are taken, after being crushed, adds in distilled water (2.75kg), fibre
Element enzyme 2.75g and papain 2.75g mixings are tieed up, adjusts pH5.5-6.0, at 30 DEG C, ferments 3 days, filters to obtain zymotic fluid, send out
Zymotic fluid is concentrated to give fermentate；
(2) fermentate that step (1) obtains is molten with the ethyl alcohol that volume fraction is 40% by AB-8 type macroporous resin adsorptions
Liquid elutes, and collects 3 times of column volume eluents, then through activated carbon decolorizing, concentration, dry the compound Chinese medicine extract (7.6g,
Hereinafter referred to as product A).
Embodiment 2
(1) dry kuh-seng 500g, dried orange peel 100g, bark of ash 300g are taken, after being crushed, addition deionized water (7.2kg),
Cellulase 9g and papain 9g mixings adjust pH6.0-6.5, at 40 DEG C, ferment 2 days, filter to obtain zymotic fluid, zymotic fluid
It is concentrated to give fermentate；
(2) fermentate that step (1) obtains is molten with the ethyl alcohol that volume fraction is 30% by D101 type macroporous resin adsorptions
Liquid elutes, and collects 5 times of column volume eluents, then through activated carbon decolorizing, concentration, dry the compound Chinese medicine extract
(12.8g, hereinafter referred to as product B).
Embodiment 3
(1) dry kuh-seng 500g, dried orange peel 50g, bark of ash 200g are taken, after being crushed, adds in distilled water (4.5kg), fibre
Element enzyme 4.5g and papain 4.5g mixings are tieed up, adjusts pH5.5-6.0, at 35 DEG C, ferments 2.5 days, filters to obtain zymotic fluid, send out
Zymotic fluid is concentrated to give fermentate；
(2) fermentate that step (1) obtains is by HPD100 type macroporous resin adsorptions, with the ethyl alcohol that volume fraction is 35%
Solution elutes, and collects 4 times of column volume eluents, then through activated carbon decolorizing, concentration, dry the compound Chinese medicine extract
(10.4g, hereinafter referred to as products C).
Embodiment 4
(1) dry kuh-seng 300g, dried orange peel 50g are taken, after being crushed, adds in distilled water (2.75kg), cellulase
2.75g and papain 2.75g mixings adjust pH5.5-6.0, at 30 DEG C, ferment 3 days, filter to obtain zymotic fluid, zymotic fluid is dense
Contract to obtain fermentate；
(2) fermentate that step (1) obtains is molten with the ethyl alcohol that volume fraction is 40% by AB-8 type macroporous resin adsorptions
Liquid elutes, and collects 3 times of column volume eluents, then through activated carbon decolorizing, concentration, dry the compound Chinese medicine extract (3.2g,
Hereinafter referred to as product D).
Embodiment 5
(1) dry dried orange peel 50g, bark of ash 200g are taken, after being crushed, adds in distilled water (2.75kg), cellulase
2.75g and papain 2.75g mixings adjust pH5.5-6.0, at 30 DEG C, ferment 3 days, filter to obtain zymotic fluid, zymotic fluid is dense
Contract to obtain fermentate；
(2) fermentate that step (1) obtains is molten with the ethyl alcohol that volume fraction is 40% by AB-8 type macroporous resin adsorptions
Liquid elutes, and collects 3 times of column volume eluents, then through activated carbon decolorizing, concentration, dry the compound Chinese medicine extract (2.1g,
Hereinafter referred to as product E).
Embodiment 6
(1) dry kuh-seng 300g, bark of ash 200g are taken, after being crushed, adds in distilled water (2.75kg), cellulase
2.75g and papain 2.75g mixings adjust pH5.5-6.0, at 30 DEG C, ferment 3 days, filter to obtain zymotic fluid, zymotic fluid is dense
Contract to obtain fermentate；
(2) fermentate that step (1) obtains is molten with the ethyl alcohol that volume fraction is 40% by AB-8 type macroporous resin adsorptions
Liquid elutes, and collects 3 times of column volume eluents, then through activated carbon decolorizing, concentration, dry the compound Chinese medicine extract (5.4g,
Hereinafter referred to as product F).
Embodiment 7
(1) dry kuh-seng 300g, dried orange peel 10g, bark of ash 200g are taken, after being crushed, adds in distilled water (2.75kg), fibre
Element enzyme 2.75g and papain 2.75g mixings are tieed up, adjusts pH5.5-6.0, at 30 DEG C, ferments 3 days, filters to obtain zymotic fluid, send out
Zymotic fluid is concentrated to give fermentate；
(2) fermentate that step (1) obtains is molten with the ethyl alcohol that volume fraction is 40% by AB-8 type macroporous resin adsorptions
Liquid elutes, and collects 3 times of column volume eluents, then through activated carbon decolorizing, concentration, dry the compound Chinese medicine extract (6.2g,
Hereinafter referred to as product G).
Embodiment 8
Dry kuh-seng 300g, dried orange peel 50g, bark of ash 200g are taken, after being crushed, adds in distilled water (2.75kg) mixing,
PH5.5-6.0 is adjusted, at 30 DEG C, impregnates 3 days, filters to get filtrate, by AB-8 type macroporous resin adsorptions after filtrate concentration, uses body
The ethanol solution that fraction is 40% elutes, and collects 3 times of column volume eluents, then through activated carbon decolorizing, concentration, dry described
Compound Chinese medicine extract (4.6g, hereinafter referred to as product H).
9 antibacterial activity of embodiment is tested
Product A-H is configured to the solution of 50 μ g/mL respectively, it is tested to E. coli with inhibition zone method
The bacteriostatic activity of ATCC25922, staphylococcus aureus S.aureus ATCC25923.It the results are shown in Table 1.
Table 1
| Test sample | E.coli ATCC25922(mm) | S.aureus ATCC25923(mm) |
| Product A | 20.2 | 23.5 |
| Product B | 19.3 | 22.6 |
| Products C | 19.5 | 23.0 |
| Product D | 16.8 | 17.2 |
| Product E | 13.6 | 13.5 |
| Product F | 17.0 | 17.2 |
| Product G | 17.7 | 19.3 |
| Product H | 16.3 | 16.9 |
Note：Data represent the diameter (a diameter of 12.80mm containing filter paper) of inhibition zone in table
10 product A-H of embodiment is to dimethyl sulfide (Me2S removing experiment)
The dimethyl disulfide ethereal solution for being 1% with absolute ethyl alcohol configuration 450mL mass fractions, is divided into 9 parts (every part of 50mL),
8 parts of addition each 3mg of product A-H thereto respectively, the 9th part of dimethyl disulfide ethereal solution is not added with any sample as control, containing A-H
8 parts of solution at 37 DEG C, react 1 hour, with gas chromatography-mass spectrography (GC-MS) detection dimethyl sulfide content, knot
Fruit is shown in Table 2.
Table 2
| Number | Add in sample | Dimethyl disulfide ether content |
| 1 | Product A | 0.26% |
| 2 | Product B | 0.30% |
| 3 | Products C | 0.29% |
| 4 | Product D | 0.76% |
| 5 | Product E | 0.80% |
| 6 | Product F | 0.92% |
| 7 | Product G | 0.62% |
| 8 | Product H | 0.82% |
| 9 | Nothing | 0.96% |
Embodiment 11
1 part of product A, 0.02 part of sodium fluoride, 7 parts of lauryl sodium sulfate, 5 parts of sorbierite, water 10 are weighed according to parts by weight
Part stirring forms mixed solution, adds in 20 parts of calcium carbonate, 2 parts of sodium carboxymethylcellulose, 3 parts of peppermint oil according still further to parts by weight, stirs
Grinding 0.5 hour is mixed, vacuum outgas cream, (deposit cream, filling) are packed up to the deodorization and sterilization Chinese medicinal toothpaste.
Embodiment 12
2 parts of product B, 0.05 part of chlorophyll, 10 parts of sodium lauroyl sarcosine, 5 parts of sorbierite, water are weighed according to parts by weight
15 parts of stirrings form mixed solution, and 20 parts of calcium carbonate, 0 part of silica 1,1 part of xanthans, extra large bath acid are added in according still further to parts by weight
1 part of sodium, 2 parts of menthol, 3 parts of folium artemisiae argyi essence, agitation grinding 1.0 hours, vacuum outgas cream, (deposit cream, filling) are packed to obtain the final product
The deodorization and sterilization Chinese medicinal toothpaste.
Embodiment 13
1 part of products C, 0.03 part of sodium fluoride, 8 parts of phenolic group sodium glutamate, 8 parts of glycerine, 10 parts of water are weighed according to parts by weight to stir
It mixes to form mixed solution, 20 parts of calcium carbonate, 2 parts of hibbsite, 2.5 parts of carragheen, peppermint oil 2 is added in according still further to parts by weight
Part, 2 parts of menthol, agitation grinding 45 minutes, vacuum outgas cream, (deposit cream, filling) are packed up to the deodorization and sterilization Chinese medicine
Toothpaste.
Parts by weight in embodiment 11-13, every part of expression 10g.
Claims (7)
1. a kind of deodorization and sterilization Chinese medicinal toothpaste, it is characterised in that the Chinese medicinal toothpaste includes following ingredient：
1-2 parts of compound Chinese medicine extract, active 0.02-0.05 parts of additive, 20-30 parts of rubbing agent, 15-20 parts of wetting agent, table
Activating agent 7-10 parts of face, 2-3 parts of adhesive, 3-5 parts of fragrance；
The formula of the compound Chinese medicine extract, by weight herbal mixture is 3-5 parts of kuh-seng, 0.5-1 parts of dried orange peel, bark of ash 2-
3 parts.
2. deodorization and sterilization Chinese medicinal toothpaste described in claim 1, it is characterised in that the preparation method of the compound Chinese medicine extract,
Include the following steps：
(1) dry kuh-seng, dried orange peel, the bark of ash are measured by formula, after being crushed, adds in water, suitable cellulase and pawpaw
Protease mixing adjusts pH5.5-6.5, at 30-40 DEG C, ferments 2-3 days, filters to obtain zymotic fluid, zymotic fluid is concentrated to give fermentate；
(2) fermentate that step (1) obtains is eluted by macroporous resin adsorption, the ethanol solution for being 30-40% with volume fraction,
3-5 times of column volume eluent is collected, then through activated carbon decolorizing, concentration, dry the compound Chinese medicine extract.
3. the deodorization and sterilization Chinese medicinal toothpaste described in claim 2, it is characterised in that the preferred distilled water of water or deionization in step (1)
Water, the quality dosage of water is kuh-seng, 5-8 times of dried orange peel, bark of ash quality sum, the quality dosage of cellulase be kuh-seng, dried orange peel,
The mass ratio of the 0.5-1.0% of bark of ash quality sum, papain and cellulase is 1:1.
4. claim 1-3 any one of them deodorization and sterilization Chinese medicinal toothpastes, it is characterised in that the activity additive is selected from leaf
Green element or sodium fluoride, rubbing agent is selected from one or more of calcium carbonate, calcium monohydrogen phosphate, silica, hibbsite, wet
Moisten agent and be selected from one or more of water, glycerine, sorbierite, surfactant is selected from lauryl sodium sulfate, lauroyl flesh ammonia
One or more of sour sodium, phenolic group sodium glutamate, Cocoamidopropyl betaine, adhesive be selected from xanthans, extra large bath acid sodium,
One or more of hydroxyethyl cellulose, guar gum, sodium carboxymethylcellulose, carragheen, fragrance are selected from peppermint oil, peppermint
One or more of alcohol, folium artemisiae argyi essence.
5. the preparation method of claim 1-4 any one of them deodorization and sterilization Chinese medicinal toothpastes, it is characterised in that including walking as follows
Suddenly：
According to parts by weight weigh described compound Chinese medicine extract 1-2 parts, active 0.02-0.05 parts of additive, surfactant 7-
10 parts, 15-20 parts of stirrings of wetting agent form mixed solution, according still further to parts by weight add in 20-30 parts of rubbing agent, 2-3 parts of adhesive,
3-5 parts of fragrance, agitation grinding 0.5-1 hours, vacuum outgas cream are packed up to the deodorization and sterilization Chinese medicinal toothpaste.
6. application of the claim 1-4 any one of them deodorization and sterilization Chinese medicinal toothpastes in volatile sulfur compounds are removed.
7. the application described in claim 6, it is characterised in that the preferred dimethyl sulfide of the volatile sulfur compounds, hydrogen sulfide, first
One or more of mercaptan.
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| CN201810233480.4A CN108158913B (en) | 2018-03-20 | 2018-03-20 | Sterilizing and deodorizing traditional Chinese medicine toothpaste and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109381385A (en) * | 2018-09-07 | 2019-02-26 | 南京医科大学附属口腔医院 | A kind of auxiliary ultrasonic, which cleans one's teeth, dispels tartar oral care composition, preparation method and application |
| CN110368327A (en) * | 2019-08-14 | 2019-10-25 | 广州益凡医疗器械有限公司 | A kind of plaque removes gel and preparation method thereof |
| WO2020062389A1 (en) * | 2018-09-28 | 2020-04-02 | 温伟成 | Formulation and process for preparing toothpaste from xinhui tangerine peel extract liquid |
| CN113384487A (en) * | 2021-06-30 | 2021-09-14 | 广州名大实业有限公司 | Formula of toothpaste capable of efficiently removing smoke spots |
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| CN110368327A (en) * | 2019-08-14 | 2019-10-25 | 广州益凡医疗器械有限公司 | A kind of plaque removes gel and preparation method thereof |
| CN113384487A (en) * | 2021-06-30 | 2021-09-14 | 广州名大实业有限公司 | Formula of toothpaste capable of efficiently removing smoke spots |
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| CN108158913B (en) | 2020-10-27 |
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