KR102051521B1 - Preparation method of composition for preventing hair loss or promoting hair growth - Google Patents

Abstract

The present invention relates to a method for preparing a hair loss prevention and hair growth promotion composition, which comprises: a step (a) of inserting Eclipta prostrata L., Prunella vulgaris L, Houttuynia cordata Thunb., Chrysanthemum morifolium Ramat., and mugwort into water, heating the mixture, and stopping heating when reaching a first heating temperature of 100 to 120°C, to naturally cool the mixture at room temperature and perform extraction, thereby acquiring a first extract; a step (b) of inserting Xanthium strumarium L., Portulaca oleracea L., Fallopia multiflora Haraldson, mint, Angelica gigas Nakai, Dictamnus dasycarpus Turcz., Acorus gramineus Soland, Cnidium officinale Makino, and Saururus chinensis Baill into water, heating the mixture, and performing extraction while maintaining a second heating temperature when reaching the second heating temperature of 70 to 90°C to acquire a second extract; a step (c) of mixing and heating the first extract, from which solid contents are removed, of the step (a) and the second extract including solid contents of the step (b) and performing extraction while maintaining a third heating temperature when reaching the third heating temperature of 70 to 90°C to acquire a third extract; a step (d) of removing solid contents from the third extract, naturally cooling the third extract at room temperature, and adding extracts of Urtica dioica, red ginseng, and espinogilia to the third extract to acquire a medicinal herb extract; and a step (e) of adding a pH adjuster to the medicinal herb extract to adjust the pH by 5 to 7. Accordingly, provided is a composition for hair loss prevention and hair growth promotion, which is not harmful to a human body, activates scalp tissues to prevent hair loss and promote hair growth, and supplies nutrition to a grown hair to thicken the hair.

Description

Preparation method of composition for preventing hair loss or promoting hair growth

The present invention relates to a composition for preventing hair loss or promoting hair loss, and more particularly, nasturtium, changja, machihyeon, sesao, hagocho, tangui, baekseonpi, Seokchangpo, gamguk, cheongung, wormwood, peppermint, eoseongcho and three hundred candles The present invention relates to a method for preparing a composition for preventing hair loss or promoting hair growth that is effective in regenerating hair and not harmful to the human body.

Human hair is about 100,000 to 150,000 pieces and is formed in "hair follicles". The hair follicle contains the papilla, which contains a small blood vessel that distributes the nutrients needed to grow the hair and the seborrheic glands that supply oil to the hair on the side of the teat. Hair follicles consist of several different epithelial cells and dermal papilla cells (DPCs). DPCs are mesenchymally-derived fibroblasts located at the base of hair follicles and play an important role in hair growth. In particular, minoxidil has been reported to have proliferative and anti-apoptotic effects on DPCs. Similarly, several reports have shown an increase in hair growth through the proliferation of DPCs. Each hair has a different cycle and grows and falls through the anagen, catagen and telogen phases. This cycle is repeated over three to six years, with an average of 50 to 100 hairs falling out daily. In general, alopecia refers to an abnormally large number of hairs falling out due to shortening of the growth phase hair and more degenerative or resting hairs during these cycles.

Currently, the prevention and treatment of alopecia are divided into medical and oriental approaches. Medical approaches include drug therapy, surgical methods, nutrition and diet. Drugs that promote hair growth include minoxidil (MXD) and finasteride, which are certified by the Food and Drug Administration (FDA). However, the minoxidil and finasteride are reported to have a problem that the hair loss proceeds as usual when the treatment is stopped, and that side effects such as dermatitis occur when used for a long time.

Therefore, to overcome the problems of the hair loss prevention and treatment as described above, there is no need for research on the prevention and treatment of hair loss prevention and therapeutic food or pharmaceutical products containing natural products with high stability.

Patent Documents 1. Korean Registered Patent Publication No. 10-1440061 Patent Document 2. Korean Patent Publication No. 10-1830864

The present invention has been devised in view of the above problems, the object of the present invention is the nasturtium, Changja, Machihyeon, Shouao, Hagocho, Angelica, Baeksunpi, Seokchangpo, Gamguk, Cheonggung, Mugwort, Mint, Eoseongcho and Three hundred candles There is no harm to the human body, it is possible to prevent hair loss and promote hair growth by activating the scalp tissue, and furthermore to nourish the grown hair hair loss thickening and hair growth promoting composition for producing a composition for promoting hair growth To provide.

One aspect of the present invention for achieving the object as described above (a) by heating the nasturtium vinegar, haegocho, eoseongcho, gamguk and wormwood in water to reach the first heating temperature between 100 to 120 ℃ stops heating Thereafter, extracting the mixture by natural cooling to room temperature to obtain a first extract; (b) Changchang, Machihyeon, Sewao, Peppermint, Angelica, Baeksunpi, Seokchangpo, Cheongungpo, and Three hundred seconds in water, when heated to reach the second heating temperature between 70 ~ 90 ℃ by extracting while maintaining the second heating temperature Obtaining a second extract; (c) mixing the first extract from which the solid is removed in step (a) and the second extract comprising the solid in step (b) and heating to reach a third heating temperature between 70 and 90 ° C .; Obtaining a third extract by extracting while maintaining the heating temperature; (d) removing the solids from the third extract and naturally cooling to room temperature, and then adding a nettle extract, red ginseng extract, and espinolithia extract to obtain an herbal extract, and (e) adding a pH adjuster to the herbal extract. It relates to a method for producing a composition for preventing hair loss or hair growth comprising adjusting to pH 5 to 7.

According to one embodiment, the extraction time of step (a) is 3 to 10 hours, the extraction time of step (b) may be 1 to 60 minutes.

According to another embodiment, the extraction time of step (c) may be 1 to 10 minutes.

According to another embodiment, the step (a) uses 20 to 30 parts by weight of nasturtium, 10 to 15 parts by weight of haechocho, 1 to 5 parts by weight of edible vinegar, 1 to 5 parts by weight of persimmon soup and 1 to 5 parts by weight of wormwood ; The step (b) is Changja 20 to 30 parts by weight, gusset 10 to 15 parts by weight, sewage 10 to 15 parts by weight, mint 1 to 5 parts by weight, Angelica 1 to 5 parts by weight, ringworm skin 1 to 5 parts by weight, Seokchangpo 1 to 5 parts by weight, 1 to 5 parts by weight, and 1 to 5 parts by weight of 300 seconds may be used.

According to another embodiment, the step (d) may be used 10 to 15 parts by weight of the nettle extract, 10 to 15 parts by weight of red ginseng extract and 10 to 15 parts by weight of the episnozilia extract.

According to another embodiment, the extraction time of step (a) is 6 to 7 hours; The extraction time of step (b) is 25 to 35 minutes; The extraction time of step (c) is 5 to 6 minutes; The step (a) uses 18 to 22 parts by weight of Hannyeoncho, 10 to 12 parts by weight of Hagocho, 1 to 3 parts by weight of Echo, 1 to 3 parts by weight of persimmon soup and 1 to 3 parts by weight of wormwood; The step (b) is Changja 18 to 22 parts by weight, gusset 10 to 12 parts by weight, sewage 10 to 12 parts by weight, mint 1 to 3 parts by weight, Angelica 1 to 3 parts by weight, ringworm skin 1 to 3 parts by weight, Seokchangpo 1 to 3 parts by weight, 1 to 3 parts by weight of uterus and 1 to 3 parts by weight of 300 seconds are used; The step (d) uses 10 to 12 parts by weight of the nettle extract, 10 to 12 parts by weight of red ginseng extract and 10 to 12 parts by weight of episnozilia extract; The pH adjuster may be natural citric acid.

Another aspect of the present invention relates to a hair loss preventing or hair growth promoting composition prepared according to the production method of the present invention.

According to one embodiment, the composition may be in any one form selected from hair shampoo, hair conditioner, hair essence, hair oil, hair spray, hair aerosol, hair gel, cream, toner and soap.

According to the present invention, the nasturtium, Changja, Machihyeon, sewage, haegocho, donkey, Baeksunpi, Seokchangpo, Gamkook, Cheongung, wormwood, peppermint, eoseongcho and three hundreds constituents are not harmful to the human body, activate the scalp tissue hair loss To prevent and promote hair growth, it can further provide a method for producing a composition for preventing hair loss and hair growth to nourish the grown hair to thicken the hair.

As used herein, "hair loss" refers to a phenomenon in which hair falls off from the scalp or a condition in which the hair is coarse or thin, and "hair loss prevention" means preventing and inhibiting hair loss as described above, and "hair growth". "Promoting" means promoting the production of new hair as well as allowing existing hair to grow healthy. In general, "hair growth" occurs in the growth phase and is promoted by induction from the resting phase to the growth phase and the delay from the growth phase to the regression phase. The hair cycle can be divided into three main stages, known as the growing phase, the catenary phase and the resting phase. In the growth phase, hair growth occurs as hair follicles grow deep into the skin with rapid proliferation of cells. The next phenomenon is the degenerative phase, which is a transitional period in which the disruption of cell division is prominent, during which hair follicles gradually degenerate and hair growth ceases. In the next phase, the resting phase, the degenerative hair follicles contain germs with densely packed dermal papilla cells. The onset of new growth phase phenomena at rest is induced by rapid cell proliferation in the embryo, swelling of the dermal papilla and the synthesis of basement membrane elements.

Therefore, it is necessary to prevent hair loss, that is, to prevent hair loss or to induce hair regrowth, i.e., to promote hair growth by promoting or extending the growth phase, and the composition according to the present invention has the effect of preventing the existing hair from falling out. At least one of the effects of thickening already existing hair and the like, and creating new hair. Dermal papilla cells are mesodermal-derived fibroblasts located at the base of hair follicles and are thought to play an important role in hair growth by interacting with hair follicle matrix cells (Jahoda CA, et al., 1984; Oliver RF, et al., 1986). Minoxidil, which is used as a hair loss treatment, is a KATP-channel opener and has been shown to increase growth in NIH3T3 fibroblasts (Sanders, et al., 1996). In addition, the composition according to the present invention can induce hair growth by activating dermal papilla cells (DPCs) and fibroblasts.

In addition, "Alopecia" herein may include any hair loss classified in the art as hair loss except for scar (rebound) alopecia. For example, it may mean one or more of alopecia areata, masculine alopecia, hair loss, female alopecia, pediatric alopecia, alopecia, alopecia, drug hair loss, and seborrheic alopecia with scalp skin diseases such as seborrheic dermatitis or psoriasis. .

Hereinafter, various aspects and various embodiments of the present invention will be described in more detail.

One aspect of the present invention (a) by putting the nasturtium, Hagocho, Echoseong, gamguk and wormwood in the water to reach the first heating temperature between 100 to 120 ℃ after stopping the heating, natural cooling to room temperature extraction Thereby obtaining a first extract; (b) Changchang, Machihyeon, Sewao, Peppermint, Angelica, Baeksunpi, Seokchangpo, Cheongungpo, and Three hundred seconds in water, when heated to reach the second heating temperature between 70 ~ 90 ℃ by extracting while maintaining the second heating temperature Obtaining a second extract; (c) mixing the first extract from which the solid is removed in step (a) and the second extract comprising the solid in step (b) and heating to reach a third heating temperature between 70 and 90 ° C .; Obtaining a third extract by extracting while maintaining the heating temperature; (d) removing the solids from the third extract and naturally cooling to room temperature, and then adding a nettle extract, red ginseng extract, and espinolithia extract to obtain an herbal extract, and (e) adding a pH adjuster to the herbal extract. It relates to a method for producing a composition for preventing hair loss or hair growth comprising adjusting to pH 5 to 7.

As a specific example, the step (a) is 20 to 30 parts by weight of Hannyeoncho, 10 to 15 parts by weight of Hagocho, 1 to 5 parts by weight of Echo vinegar, 1 to 5 parts by weight of persimmon soup and 1 to 5 parts by weight of wormwood in water and 100 to 120 Upon reaching the first heating temperature between < RTI ID = 0.0 > C, < / RTI > the first extract can be obtained by stopping the heating and extracting by natural cooling to room temperature for 3 to 10 hours, preferably 5 to 8 hours, more preferably 6 to 7 hours. Can be.

Next, the step (b) is 20 to 30 parts by weight, 10 to 15 parts by weight, 10 to 15 parts by weight of sewage, 10 to 15 parts by weight of sewage, 1 to 5 parts by weight of mint, 1 to 5 parts by weight of angelica, 1 to 5 weights of ringworm skin. Part 1, 5 parts by weight of Seokchangpo, 1-5 parts by weight of Cheongung and 1-5 parts by weight of three hundred seconds in water to reach a second heating temperature between 70 to 90 ℃ 1 to 1 while maintaining the second heating temperature The second extract can be obtained by extraction for 60 minutes, preferably 10 to 50 minutes, more preferably 25 to 35 minutes.

Next, the step (c) is a third heating temperature between 70 to 90 ℃ by mixing and heating the first extract from which the solid of step (a) and the second extract containing the solid in step (b) When reaching the third extract can be obtained by extracting for 1 to 10 minutes, preferably 3 to 8 minutes, more preferably 5 to 6 minutes while maintaining the third heating temperature.

Next, the step (d) is to remove the solids from the third extract and then naturally cooled to room temperature, 10 to 15 parts by weight of the nettle extract, 10 to 15 parts by weight of red ginseng extract and 10 to 15 parts by weight of Espinoglia extract It can be added to obtain a herbal extract.

The extraction solvent used in the extraction of the extract wool is water, lower alcohol having 1 to 4 carbon atoms, mixed solvent of the lower alcohol and water, acetone, ethyl acetate, chloroform, butyl acetate, 1,3-butylene glycol, hexane, Diethyl ether and the like can be used, more preferably water and ethanol can be used. More preferably, the extraction may be hydrothermal extraction for 3 to 6 hours to put the nettle, red ginseng and Espinoglia each in boiling water.

As used herein, the term 'extract' has a meaning commonly used as a crude extract in the art, but may broadly include a fraction additionally fractionating the extract.

Finally, step (e) is carried out in citric acid, acetic acid, ascorbic acid, gamma linolenic acid, lactobio acid, lactic acid, phosphoric acid, tartaric acid, triethanolamine, sodium silicate, sodium hydroxide, sodium citrate, sodium carbonate and sodium borate Through the addition of one or more pH adjusters selected, the acidity can be adjusted to pH 5-7, in which irritation of the scalp is alleviated. It is not limited only to the said pH adjuster kind, Preferably natural citric acid can be used.

In particular, (iv) the extraction time of step (a) is 6 to 7 hours; (Ii) the extraction time of step (b) is from 25 to 35 minutes; (Iii) the extraction time of step (c) is from 5 to 6 minutes; (Iii) the step (a) uses 18 to 22 parts by weight of nasturtium, 10 to 12 parts by weight of haechocho, 1 to 3 parts by weight, 1 to 3 parts by weight of persimmon soup, and 1 to 3 parts by weight of wormwood; (Iii) step (b) is Chang-za 18 to 22 parts by weight, 10 to 12 parts by weight of machi, 10 to 12 parts by weight, 1 to 3 parts by weight of mint, 1 to 3 parts by weight, donkey 1 to 3 parts by weight Parts, 1 to 3 parts by weight of Seokchangpo, 1 to 3 parts by weight of Cheongung and 1 to 3 parts by weight of three hundred seconds; (Iii) the step (d) uses 10 to 12 parts by weight of the nettle extract, 10 to 12 parts by weight of red ginseng extract and 10 to 12 parts by weight of the episnozilia extract; (Iii) When the pH adjuster is satisfied with all the conditions of natural citric acid, it showed remarkably excellent all-cell proliferation promoting ability and capillary expansion ability, and as a result, it was confirmed that the hair loss improvement and hair growth effect are very excellent.

Hereinafter, each natural product component contained in the composition of the present invention will be described in detail.

Hanryoncho is an annual herb that grows on rice fields, and uses the ground part as a medicinal part. It is cold in nature, sweet in taste, and suitable for hair loss due to upper heat in young people, lowers heat and has excellent hemostatic effect, has antibacterial, anti-inflammatory, anti-fungal effect, clears blood and strengthens immune function, boils Good for the treatment of and itching. In particular, it is known that nasturtium blackens beard and gray hair, and is effective in preventing hair loss and promoting hair growth.

Changsha is the fruit of the Asteraceae's Xanthium strumarium L. It has no smell, tastes spicy, bitter, warm and toxic. Changzaza contains xanthostromarine, resin, and iodine salts.Changjaza is a medicinal herb that eliminates winds, which causes sinusitis, rhinitis, headaches, fever, cough, pain in the limbs, inability to swell, and skin itching and otitis media. Write Pharmacological actions have been reported on toxic reactions to essential oils and alkaloids, hypoglycemia, prevention of leukocyte reduction, cough, and heart suppression.

March is the outpost of purslane and uses the ground as a medicinal part. It has been widely used as a skin ointment raw material because of its excellent healing effect. It prevents dryness of the skin and has excellent anti-inflammatory action. It is very effective in calming skin irritation and allergic reactions. It has antibacterial action and excellent skin moisturizing power. It also has the same effect on the scalp and is known to be good for hair loss and dandruff.

Sewage sludge is in a tuberous root belonging to polygonaceae (polygonaceae), medicated portion uses the root. Along with ginseng and goji berry, it is called the three major energetic vines and has a high name as a medicinal herb for long-lived nourishment. It is also known to protect energy and energy, to blacken the head, to improve the function of the liver, to get rid of tiredness, to strengthen the brain, to replenish blood, and to reduce the effects of nervous breakdown and insomnia.

Prunella is a plant in the genus Prunella , and medicinal parts use flower beds. Pharmacological studies are known to have effects such as blood pressure lowering, antiviral, anti-inflammatory, vibration, and lowering blood sugar.

Angelica is a perennial aromatic herb belonging to the Apiaceae, and its root is used as a medicinal part. The main ingredients are coumarin derivatives such as decursin, decursinol, and nodakenin, and essential oils such as α-pinene, limonene, β-eudesmol and elemol are known for their scalp health and anti-inflammatory effects.

Ringworm skin is the root bark of Dictamnus dasycarpus Turcz. Its function is to remove wind, to dry wet, to reduce heat and to detoxify. It is effective in treating wind, wind, skin eczema and jaundice. In particular, the function of inhibiting fungi has been reported.

Seokchangpo is a perennial herb belonging to the genus Araceae. The medicinal part uses root stem. In addition to regulating breathing and smoothing blood circulation, it also helps to distract air, and it has the effects of dryness, humidity, and swelling. Applied diseases are used to treat the very stuffy symptoms, confused mental symptoms, forgetfulness and epilepsy. It is also known to be used for indigestion, stomach pain, abdominal pain, malignant boils, bruises from bruises and redness of the eyes.

Gamkook is a perennial herb of the dicotyledon plant Lantern Asteraceae, also known as yellow kingdom, uses flowers as medicinal parts. It has a peculiar fragrance and the weakness is a bit sweet and cold. Flowers contain essential oils, dl-camphor, tetracoic acid, hexacoic acid, terpenetone, α-tuyon, 3- (10) kalen, cristenone, luteolin, chrysanthane, and the seeds include essential oils, tannins, etc. It is contained. Cools eyes and head, stops tears and fevers down. Fever in the chest, frustrating symptoms, pneumonia, bronchitis, headache, stiff shoulders, high blood pressure is effective. It is known to be used for skin functions such as liver function, hyperemia, menstrual irregularities and acne or swelling.

Cheongung is a buttercupaceae perennial plant that uses stalks as medicinal parts. The nature is warm, spicy and aromatic. Pharmacological actions include sedation of the central nervous system, effects on the cardiovascular system, blood pressure control, and blood vessel dilation, thereby increasing blood flow, thereby enhancing blood circulation, antibacterial activity, anti-vitamin E deficiency, and anti-inflammatory effects. In particular, it acts as an anti vitamin E deficiency to protect against trophic brain diseases caused by vitamin E deficiency. It contains ferulic acid, which is rich in plant cell walls. And cholesterol lowering effect. Due to blood pressure control and blood vessel expansion, blood flow is increased to enhance blood circulation, thereby promoting hair loss and hair growth.

The wormwood is a nickname of wormwood, which is a perennial plant of the dicotyledon plant Lantern Asteraceae, uses leaves as medicinal parts. It is warm in nature and tastes very good. It has the effect of anticancer, antiseptic, toxin decomposition, blood circulation, relaxation of blood vessels, and improves immune function. Vitamin A, B ₁ , B ₂ , C, calcium, potassium, Phosphorus, protein, minerals, etc. are rich in alkaline medicine to clear the blood. In particular, the herbaceous tree 15 is said to be effective in treating fever and skin diseases such as swelling. In particular, it is known that the scalp is in an unclean state or is accumulating by dandruff and is effective in treating tumors caused by propagated bacteria.

Peppermint is a perennial herb with nectar and uses the ground part as a medicinal part. Peppermint stem and leaves contain volatile essential oils, containing 77% of menthol, the main ingredient, and have a strong divergence, which helps to control the symptoms of fever, headache and sweating due to colds, and headache and eye redness. It is used for itching and itching of the skin. It is used to mix abdominal pain, diarrhea and vomiting caused by invasion of moisture and pathogens in summer.

Eoseongcho is a perennial herbaceous wild herb belonging to the Saururaceae , and is native to China, Japan, and Korea, and uses the ground part as a medicinal part. Eochocho is a traditional medicinal plant and has been reported to have a wide range of therapeutic effects such as species, syphilis, cystitis, uterus, pneumonia, and stroke. To date, Echochochoe research has been conducted on antimicrobial activity, antioxidant, anti-tumor, anti-leukemia and hyperlipidemia Inhibitory effects have been reported and have been reported to have a variety of biologically active functions.

Sambaekcho is a perennial herb from Jeju and some parts of Jirisan. It is called Sambaekcho because its roots, leaves, and flowers are white, and the medicinal part uses ground and root stems. It contains quercetin and quercitrin, which releases harmful cholesterol in blood vessels and improves blood circulation. It is effective for hair loss when used as a pack, and ginseng has the effect of treating the affected area by washing the affected area such as eczema and itching. Machi Prefecture is known for its excellent anti-inflammatory, antibacterial, allergic, astringent and moisturizing effects.

Another aspect of the present invention relates to a hair loss preventing or hair growth promoting composition prepared according to the production method of the present invention.

According to one embodiment, the composition for preventing hair loss or promoting hair growth according to the present invention may be prepared as a cosmetic composition that can be applied to the scalp and hair, such as liquid, cream, paste or solid.

The cosmetic composition may be any one type selected from hair shampoo, hair conditioner, hair essence, hair oil, hair spray, hair aerosol, hair gel, cream, toner and soap, but is not limited thereto. Various types of cosmetics that can be contacted can be used.

According to another embodiment, the components included in the cosmetic composition of the present invention include components conventionally used in cosmetic compositions in addition to the above components, for example, such as antioxidants, stabilizers, solubilizers, vitamins, fragrances Phosphorus supplements, and diluents. Cosmetic compositions of the present invention may be prepared in any formulation conventionally prepared in the art, for example solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing, oils It may be formulated, such as, but not limited to. More specifically, it may be prepared in the form of facial cleansing, lotion, cream, massage cream, eye cream, essence, gel, pack, spray, powder, sun cream and the like.

 When the formulation of the present invention is a paste, cream or gel, vegetable oil, wax, starch, cellulose, silicone, bentonite, silica, zinc oxide, etc. may be used as a carrier component, and when the formulation is powder, lactose, silica as a carrier component. Powders such as aluminum hydroxide, calcium silicate and the like can be used. When the formulation of the present invention is a solution or emulsion, a solvent, solubilizing agent or emulsifying agent is used as the carrier component, such as water, ethanol, glycerin, ethyl carbonate, ethyl acetate, propylene glycol, butylene glycol, 1 , 2-hexanediol, glycerol aliphatic ester, sorbitan fatty acid ester.

When the dosage form of the present invention is a suspension, as a carrier component, water, ethanol, liquid diluents such as propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Microcrystalline cellulose, aluminum metahydroxide, bentonite, agar and the like can be used. In addition, when the formulation is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, isethionate, methyltaurate, sarcosinate, an alkylamidobetaine, an aliphatic alcohol, a fatty acid glycerol. Ride, vegetable oil or ethoxylated glycerol fatty acid ester and the like can be used.

According to another embodiment, the hair loss preventing or hair growth promoting composition according to the present invention may be in the form of a pharmaceutical composition.

The pharmaceutical composition of the present invention may be prepared using a pharmaceutically acceptable and physiologically acceptable adjuvant in addition to the above components, and the adjuvant may include excipients, disintegrants, sweeteners, binders, coatings, swelling agents, lubricants, lubricants. Or a flavoring agent can be used.

The pharmaceutical composition may be preferably formulated into a pharmaceutical composition comprising one or more pharmaceutically acceptable carriers in addition to the active ingredient described above for administration.

Formulation forms of the pharmaceutical composition may be granules, powders, tablets, coated tablets, capsules, suppositories, solutions, syrups, juices, suspensions, emulsions, drops or injectable solutions. For example, for formulation in the form of tablets or capsules, the active ingredient may be combined with an oral, nontoxic, pharmaceutically acceptable inert carrier such as ethanol, glycerol, water and the like. In addition, if desired or necessary, suitable binders, lubricants, disintegrants and coloring agents may also be included in the mixture. Suitable binders include, but are not limited to, natural and synthetic gums such as starch, gelatin, glucose or beta-lactose, corn sweeteners, acacia, trackercance or sodium oleate, sodium stearate, magnesium stearate, sodium Benzoate, sodium acetate, sodium chloride and the like. Disintegrants include, but are not limited to, starch, methyl cellulose, agar, bentonite, xanthan gum, and the like.

Acceptable pharmaceutical carriers in compositions formulated as liquid solutions are sterile and biocompatible, which include saline, sterile water, Ringer's solution, buffered saline, albumin injectable solutions, dextrose solution, maltodextrin solution, glycerol, ethanol and these One or more components may be mixed and used, and other conventional additives such as antioxidants, buffers and bacteriostatic agents may be added as necessary. Diluents, dispersants, surfactants, binders and lubricants may also be added in addition to formulate into injectable formulations, pills, capsules, granules or tablets such as aqueous solutions, suspensions, emulsions and the like.

The pharmaceutical compositions of the present invention may be prepared in unit dosage form by formulating with a pharmaceutically acceptable carrier and / or excipient, according to methods which can be easily carried out by those skilled in the art. It can be prepared by incorporation into a multi-dose container. In this case, the formulation may be in the form of a solution, suspension or emulsion in an oil or an aqueous medium, or may be in the form of extracts, powders, granules, tablets or capsules, and may further include a dispersant or stabilizer.

Hereinafter, the production examples and embodiments according to the present invention will be described in detail with the accompanying drawings.

EXAMPLE

Example 1

20 g of Hannyeoncho, 10 g of Hagocho, 2 g of Eoseongcho, 2 g of Ngamguk and 2 g of Mugwort are added to water and heated to reach 100 ℃ (first heating temperature). The first extract was obtained by extraction for 6 hours (step (a)).

Next, add 20 g of Changzaza, 10 g of machi, 10 g of sewage, 2 g of peppermint, 2 g of Angelica, 2 g of white pine, 2 g of Seokchangpo, 2 g of Cheongung, and 2 g of Triticale into 80 ° C (second heating temperature). ), A second extract was obtained by extraction for 30 minutes while maintaining 80 ° C. (step (b)).

Next, when the first extract from which the solid is removed in step (a) and the second extract including the solid in step (b) are mixed and heated to reach 80 ° C. (third heating temperature), 80 ° C. is maintained. A third extract was obtained by extracting for 5 minutes while (step (c)).

Next, after removing all the solids from the third extract and naturally cooled to room temperature, 11 g of nettle extract, 11 g of red ginseng extract and 11 g of espinoglia extract were added to obtain a herbal extract (step (d)). .

Finally, by adjusting the pH to 5.5 by adding natural citric acid to the herbal extract, to prepare a composition for preventing hair loss or hair growth ((e) step).

Example 2

In the same manner as in Example 1, the extraction time of the steps (a) and (b) was all 6 hours, to prepare a composition.

Example 3

In the same manner as in Example 1, the extraction time of the steps (a) and (b) was all 30 minutes, to prepare a composition.

Example 4

In the same manner as in Example 1, the extraction time of the step (c) was 10 minutes to prepare a composition.

Example 5

The same procedure as in Example 1 was carried out except that the extraction time of step (c) was 30 minutes to prepare a composition.

Example 6

In the same manner as in Example 1, the extraction time of the step (c) was set to 1 hour, to prepare a composition.

[Comparative Example]

Comparative Example 1

In the same manner as in Example 1, in the steps (a) and (b), all the materials are put in the water at once and heated to reach 100 ℃ (first heating temperature) to stop the heating, and then naturally cooled to room temperature When the extract extracted for 6 hours (including solids) is heated in the step (c) to reach 80 ℃ (third heating temperature), to obtain a third extract by extracting for 5 minutes while maintaining 80 ℃, then ( By performing steps d) to (e), a composition was prepared.

Comparative Example 2

In the same manner as in Comparative Example 1, in the step (a) and (b) using only nasturtium, Changja, machi, sewage and hachicho, the composition was prepared.

Comparative Example 3

In the same manner as in Example 1, the step (c) is omitted, the mixture of the extract (including solids) of the steps (a) and (b) is naturally cooled to room temperature, and then (d) to By performing step (e), a composition was prepared.

Comparative Example 4

In the same manner as in Example 1, all the ingredients in the steps (a) and (b) and the three extracts of the step (d) are put in water all at once from the beginning and heated to 100 ℃ (first heating temperature) When reaching, the heating was stopped, and then cooled naturally to room temperature, and the extract (including solids) extracted for 6 hours was heated in step (c) to reach 80 ° C. (3rd heating temperature), while maintaining 80 ° C. for 5 minutes A third extract was obtained by extraction during which the composition was then prepared by performing steps (d) to (e).

Comparative Example 5

In the same manner as in Example 1, in the step (a) using 6.3 g of nasturtium, 6.3 g of hachocho, 6.3 g of eoseongcho, 6.3 g of persimmon soup and 6.3 g of wormwood;

In the step (b), the composition was prepared by using chang g 6.3 g, gusset 6.3 g, sewage 6.3 g, mint 6.3 g, Angelica 6.3 g, ringworm 6.3 g, Seokchangpo 6.3 g, Cheongung 6.3 g, and 6.3 g of 300 seconds. .

Comparative Example 6

In the same manner as in Example 1, but did not add the nettle extract, red ginseng extract and Espinoglia extract in the step (d), to prepare a composition.

Experimental Example

Experimental Example 1: Cytotoxicity Test

(1) Human keratinocyte cell culture

In order to examine the cytotoxicity of the composition according to the present invention, the human keratinocyte HaCaT cell line (Cell Lines Service, Germany) was incubated in 37 ℃, 5%, CO ₂ incubator. When the degree of culture as much as 85 to 90% of the culture vessel was shown, the cells were detached by trypsin treatment, counted, and then subcultured at 5 × 10 ³ cells / cm ² . The culture of the cells was performed with DMEM (Dubelcco'S Modified Eagle) supplemented with 10% Fetal Bovine Serum (FBS, GIBCO, Cat.No. 26140-079, USA) and 100 U / ml penicillin and 100 / ml streptomycin. Medium, GIBCO, Cat. No. 11995-065, USA). 75 T-flask (NUNC, Cat No. 156499, Danmark) was used for subculture, and 24 well plate (NUNC, Cat. No. 142475, Danmark) was used for cytotoxicity test.

(2) cytotoxicity test

MTT assay is a method of measuring the cytotoxicity of a test substance by finally forming a pigment product called formazan by using the dehydrogenase action of mitochondria, which is active only in living cells. In order to confirm that each of the compositions prepared in Comparative Examples and Examples can exhibit an improvement effect without skin irritation even during long-term use, the presence or absence of cytotoxicity against human keratinocytes was tested.

Human keratinocytes cultured in the above were counted using a heamacytometer at 5 × 10 ³ cells / well in 24 well plates and then aliquoted. After 48 hours of incubation in DMEM containing 10% FBS and 25-30% of the surface of the culture vessel, the composition of Comparative Examples and Examples of the present invention was replaced with 10% of FBS-free DMEM, which was further incubated for 24 hours. .

After incubation, 50 μl of 3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyl tetrazolium bromide (MTT, Sigma M5655, USA) solution (2.5 mg / ml) was added and incubated for an additional 3 hours. Subsequently, discard all the cell cultures, treat 200 μl of dimethyl sulfoxide (DMSO, Sigma D2650, USA) with 200 μl of each well, stir, and take 100 μl of 96 wells with Enzyme-Linked Immunosorbent Assay (ELISA). Absorbance was measured at 570 nm. The degree of cytotoxicity was expressed as a percentage based on the absorbance intensity of the control group using pure water. The results were as shown in Table 1.

Proliferation Effect (%) Control 100 Example 1 109.1 Example 2 103.1 Example 3 102.5 Example 4 101.4 Example 5 104.1 Example 6 102.4 Comparative Example 1 103.2 Comparative Example 2 99.8 Comparative Example 3 108.4 Comparative Example 4 105.3 Comparative Example 5 101.4 Comparative Example 6 102.6

Referring to Table 1, it can be seen that the composition for preventing hair loss and promoting hair growth according to the present invention does not cause scalp stimulation due to cytotoxicity even after long-term use.

Experimental Example 2: Evaluation of the dermal papilla cell proliferation promoting effect

PVGDPLTt sa produced by transfecting a polyomavirus large T gene encoding a temperature sensitive T antigen to a PVG vibrissa dermal papilla cell 6. Hereinafter, the effect of promoting dermal papilla cell proliferation of the composition according to the present invention was evaluated.

First, DP cells were prepared in 96-well plates at a concentration of about 10 ⁴ cells / well per well. The compositions of Comparative Examples and Examples of the present invention were dissolved in dimethyl sulfoxide (DMSO) or ethanol, respectively, and then serially diluted with DMEM medium having a 5% FBS serum concentration to obtain a final concentration of 10 ppm. As a control, a soybean extract extracted with 20% ethanol was used. 200 μl of the medium to which the compositions of Comparative Examples and Examples of the present invention were added were added per well, and then cultured in a 37 ° C., 5% CO ₂ incubator for about 3 days. 50 μl of each MTT solution, prepared at a concentration of 2 mg / ml, was added and then left for 4 hours in the same incubator. When it was determined that the MTT reagent was absorbed into the intracellular mitochondria, the supernatant was removed, 150 μl of DMSO was added, and stirred for 10 minutes to uniformly dissolve promazan dye. Then, the OD value was measured at 515 nm using an ELISA reader, and the number of cells was measured according to a standard curve prepared in advance. Based on the measured cell number, the dermal papilla cell proliferation promoting ability (%) of the Comparative Examples and Examples of the present invention was calculated, and the results are shown in Table 2 below.

Hair papilla cell proliferation promoting ability (%) Control 40.5 ± 0.9 Example 1 81.5 ± 1.5 Example 2 54.1 ± 1.2 Example 3 57.3 ± 0.9 Example 4 75.0 ± 1.2 Example 5 61.1 ± 1.5 Example 6 58.2 ± 0.7 Comparative Example 1 46.1 ± 1.2 Comparative Example 2 35.3 ± 0.8 Comparative Example 3 48.4 ± 1.3 Comparative Example 4 41.9 ± 1.1 Comparative Example 5 37.6 ± 0.9 Comparative Example 6 33.6 ± 0.9

Referring to Table 2, Comparative Example 1, which did not separate the material was extracted, Comparative Example 1, Nasturtium, Changja, Machihyeon, Sewao, and Hagocho using only five materials, Comparative Example 3, and (c) did not perform the step (4) Comparative Example 4, in which the extracts of step (d) were mixed together from the beginning, Comparative Example 5 using all the materials in the same weight, and Comparative Example 6 without the addition of the nettle, red ginseng and Espinoglia extract It can be seen that exhibiting significantly lower all milk cell proliferation capacity than the examples.

In addition, Examples 4 to 6, which performed the extraction time of the steps 2 to 3 and (c) for 5 minutes or more, which all performed the same extraction time of the material, all improved the ability to promote the proliferation of milk cells compared to the comparative examples. However, as compared with Example 1 it can be seen that exhibiting significantly lower all milk cell proliferation promoting ability.

Therefore, since the composition prepared from Example 1 of the present invention has a remarkably excellent hair papilla cell growth promoting effect, it can be confirmed that the hair health promotion effect through hair loss prevention and hair growth promotion is excellent.

Experimental Example  3: evaluation of capillary dilatation effect

Opening the K ⁺ channel activates mitogenesis and relaxes the vascular smooth muscles, causing blood vessels to expand. On the other hand, blocking the K ⁺ channel is known to inhibit the proliferation of NIH3T3 fibroblasts. Therefore, when the growth of NIH3T3 fibroblasts by sample processing is promoted, it can be said that the K ⁺ channel is opened, and further expansion of blood vessels is promoted.

First, NIH3T3 fibroblasts were seeded in a 24-well culture plate at a concentration of 10 ⁴ cells / well, and in DMEM medium containing 10% fetal calf serum (FCS) and 2 mM L-glutamine and no antibiotics. Incubated for 24 hours. After that, the culture medium was replaced with the medium to which the compositions of Comparative Examples and Examples of the present invention were added, and cultured for 72 hours. The method of preparing a medium to which the compositions of Comparative Examples and Examples of the present invention were added was the same as Experimental Example 1, and a soybean extract extracted with 20% ethanol was used as a control. After removing the medium, washed with PBS (without Ca ²⁺ / Mg ²⁺ ), treated with 0.5ml TE (trypsin-ethylenediamine tetraacetic acid) and incubated. DMEM containing 10% FCS was added, cells were taken and then centrifuged at 6000 rpm in EP tubes. The supernatant was removed and the remaining cell solution was suspended in 100 µl of PBS, and then the number of cells was measured using a hemocytometer. Based on this, capillary dilatation capacity of the Comparative Examples and Examples of the present invention was calculated and shown in Table 3 below.

Capillary dilatation capacity (%) Control 28.9 ± 1.2 Example 1 72.4 ± 0.8 Example 2 43.1 ± 1.2 Example 3 48.0 ± 1.4 Example 4 64.1 ± 1.0 Example 5 50.5 ± 1.5 Example 6 44.2 ± 0.7 Comparative Example 1 33.1 ± 1.1 Comparative Example 2 27.1 ± 1.0 Comparative Example 3 36.3 ± 0.8 Comparative Example 4 31.1 ± 1.2 Comparative Example 5 30.5 ± 0.8 Comparative Example 6 25.3 ± 1.1

Referring to Table 3 above, Comparative Example 1, which did not separate the material was extracted, Comparative Example 1, Nayeoncho, Changja, Comparative Examples 2, (c) using only five materials, Machihyeon, Sewao and Hagocho, did not perform the step (c) (4) Comparative Example 4, in which the extracts of step (d) were mixed together from the beginning, Comparative Example 5 using all the materials in the same weight, and Comparative Example 6 without the addition of the nettle, red ginseng and Espinoglia extract It can be seen that it shows a significantly lower capillary expansion capacity than the examples.

In addition, Examples 4 to 6, which performed the extraction time of Steps 2 to 3 and (c) for 5 minutes or more, which performed the same extraction time of the materials, have improved capillary dilatability compared to the comparative examples. It can be seen that it shows a significantly lower capillary expansion capacity compared to Example 1.

Therefore, since the composition prepared in Example 1 of the present invention shows a remarkably excellent blood improvement effect of the capillary capillaries, it can be confirmed that the hair health promotion effect is suppressed by inhibiting the progression of hair loss and promoting hair growth.

Experimental Example 4: Evaluation of Hair Growth Effect

20 adult males and 30 females aged 30 to 60 years old were selected and divided into several groups.The first group is a minoxidil 5% product marketed at a pharmacy each morning and evening. 3 months was applied to the hair loss site, and the rest of the groups were allowed to apply the composition prepared according to the comparative example and the embodiment of the present invention to the hair loss site each morning and evening for 3 months and then observed changes for 3 months. The results are summarized in Table 5 below. Table 4 below shows the score scale used in clinical trials.

score Visual judgment Subjective symptoms Hair loss at tricycle One worse worse increase 2 immutability immutability immutability 3 Little improvement Little improvement Little decrease 4 Medium improvement Medium improvement Medium reduction 5 Much improvement Much improvement Much reduced

Visual judgment Subjective symptoms Hair loss at tricycle Overall improvement (average) Minoxidil 5% group 2.8 3.2 2.9 3.0 Example 1 4.5 4.2 3.9 4.2 Example 2 3.0 2.8 3.1 2.9 Example 3 3.2 2.9 3.0 3.0 Example 4 3.4 3.5 3.6 3.5 Example 5 2.8 2.6 2.3 2.6 Example 6 2.4 2.1 2.3 2.3 Comparative Example 1 2.1 1.8 1.7 1.9 Comparative Example 2 2.0 2.1 1.6 1.9 Comparative Example 3 2.2 1.8 2.0 2.0 Comparative Example 4 1.9 1.8 1.9 1.9 Comparative Example 5 1.5 1.7 1.4 1.5 Comparative Example 6 1.6 1.9 1.7 1.7

Referring to Table 5, it can be seen that Example 1 shows a markedly improved hair loss improvement effect in the naked eye determination, subjective symptoms and hair loss during trituration compared to the minoxidil 5% group and the remaining examples and comparative examples.

Therefore, according to the present invention, the composition according to the present invention is not harmful to the human body with nasturtium, changja, machihyeon, sewage, hagocho, donkey, baekseonpi, Seokchangpo, gamguk, cheongung, wormwood, peppermint, eoseongcho and trichoco In addition, by activating the scalp tissue to prevent hair loss and promote hair growth, it can also nourish the grown hair to make the hair thicker.

Formulation Example 1 Preparation of Cosmetics in Emulsion Formulation

Cosmetics of emulsion formulations such as nutrient cosmetics, creams and essences, and cosmetics of solubilized formulations such as softening cosmetics were prepared.

To the cosmetic composition was prepared in the composition shown in Table 6. The manufacturing method is as follows.

1) The mixture which mixed the raw materials of 1-9 was heated at 65-70 degreeC.

2) 10 was added to the mixture of step 1).

3) The mixture of the raw materials of 11-13 was heated to 65-70 degreeC, and completely dissolved.

4) Through step 3), the mixture of 2) was slowly added to emulsify for 2 to 3 minutes at 8,000 rpm.

5) The raw material of 14 was dissolved in a small amount of water and then added to the mixture of step 4) and emulsified for 2 more minutes.

6) The raw materials of 15 to 17 were weighed, and then put into the mixture of step 5) and emulsified for 30 seconds.

7) After the emulsification of the mixture of step 6) through a degassing process to cool to 25 ~ 35 ℃ to prepare an emulsion cosmetic.

Furtherance Emulsifier 1 Emulsifier 2 Emulsifier 3 One Stearic acid 0.3 0.3 0.3 2 Stealy alcohol 0.2 0.2 0.2 3 Glyceryl Monostearate 1.2 1.2 1.2 4 Beeswax 0.4 0.4 0.4 5 Polyoxyethylene sorbitan
Monolauric acid ester 2.2 2.2 2.2 6 Methyl paraoxybenzoate 0.1 0.1 0.1 7 Paraoxybenzoic Acid Profiles 0.05 0.05 0.05 8 Cetylethylhexanoate 5 5 5 9 Triglycerides 2 2 2 10 Cyclomethicone 3 3 3 11 Distilled water To 100 To 100 To 100 12 Concentrated glycerin 5 5 5 13 Triethanolamine 0.15 0.15 0.15 14 Polyacrylic acid polymer 0.12 0.12 0.12 15 Pigment 0.0001 0.0001 0.0001 16 incense 0.10 0.10 0.10 17 Composition of Example 1 0.0001 One 10

Formulation Example 2 Preparation of Cosmetics in Solubilized Formulations

To the cosmetic composition of the solubilizing agent type was prepared in the composition shown in Table 7. The manufacturing method is as follows.

1) Raw materials 2 to 6 were placed in raw material 1 (purified water) and dissolved using a still mixer.

2) The raw materials of 8 to 11 were put into seven raw materials (alcohol) and completely dissolved.

3) The mixture of step 2) was solubilized with slow addition to the mixture of step 1).

Furtherance Solubilized Formulation 1 Solubilized Formulation 2 Solubilized Formulation 3 One Purified water To 100 To 100 To 100 2 Concentrated glycerin 3 3 3 3 1,3-butylene glycol 2 2 2 4 EDTA-2Na 0.01 0.01 0.01 5 Pigment 0.0001 0.0002 0.0002 6 Composition of Example 1 0.1 5 5 7 Alcohol (95%) 8 8 8 8 Methyl paraoxybenzoate 0.1 0.1 0.1 9 Polyoxyethylene
Hydrogenated Ester 0.3 0.3 0.3 10 incense 0.15 0.15 0.15 11 Cyclomethicone - - 2

Formulation example  3: Powder  Produce

500 mg of the composition of Example 1

Lactose 100 mg

Talc 10 mg

The above ingredients are mixed and filled in an airtight cloth to prepare a powder.

Formulation Example 4 Preparation of Tablet

300 mg of the composition of Example 1

Corn starch 100 mg

Lactose 100 mg

2 mg magnesium stearate

After mixing the above components, tablets are prepared by tableting according to a conventional method for preparing tablets.

Formulation Example 5 Preparation of Capsule

200 mg of the composition of Example 1

3 mg of crystalline cellulose

Lactose 14.8 mg

Magnesium Stearate 0.2 mg

According to a conventional capsule preparation method, the above ingredients are mixed and filled into gelatin capsules to prepare capsules.

Formulation Example 6 Preparation of Injection

600 mg of the composition of Example 1

Mannitol 180 mg

Sterile distilled water for injection 2974 mg

Na ₂ HPO _4, 12H ₂ O 26 mg

According to the conventional method for preparing an injection, the amount of the above ingredient is prepared per ampoule.

Formulation Example 7 Preparation of Liquid

4 g of the composition of Example 1

10 g of isomerized sugar

5 g of mannitol

Purified water

According to the conventional method of preparing a liquid solution, each component is added to the purified water to dissolve it, the lemon flavor is added appropriately, the above ingredients are mixed, the purified water is added, the whole is adjusted to 100 g by adding purified water, and then filled in a brown bottle. The solution is prepared by sterilization.

Formulation Example 8: Preparation of Granules

1,000 mg of the composition of Example 1

Vitamin mixture proper amount

70 μg of Vitamin A Acetate

Vitamin E 1.0 mg

Vitamin B1 0.13 mg

Vitamin B2 0.15 mg

Vitamin B6 0.5 mg

0.2 μg of vitamin B12

Vitamin C 10 mg

10 μg biotin

Nicotinamide 1.7 mg

Folate 50 ㎍

Calcium Pantothenate 0.5 mg

Mineral mixture

Ferrous Sulfate 1.75 mg

Zinc Oxide 0.82 mg

Magnesium carbonate 25.3 mg

15 mg potassium monophosphate

Dicalcium Phosphate 55 mg

Potassium Citrate 90 mg

Calcium Carbonate 100 mg

Magnesium chloride 24.8 mg

Although the composition ratio of the above-mentioned vitamin and mineral mixtures is a composition which is relatively suitable for granules in a preferred embodiment, the composition ratio may be arbitrarily modified, and the above components are mixed according to a conventional granulation method and then granulated. It can be prepared and used in the manufacture of health functional food composition according to a conventional method.

Formulation Example 9 Preparation of Functional Drink

1,000 mg of the composition of Example 1

Citric Acid 1,000 mg

100 g oligosaccharides

Plum concentrate 2 g

1 g of taurine

Add 900 mL of purified water

After mixing the above components in accordance with the conventional healthy beverage production method, and stirred and heated at 85 ℃ for about 1 hour, the resulting solution is filtered and obtained in a sterilized 2 L container, sealed sterilization and refrigerated Used to prepare functional beverage compositions of the invention.

Although the composition ratio is a composition that is relatively suitable for the preferred beverage in a preferred embodiment, the compounding ratio may be arbitrarily modified according to regional and ethnic preferences such as demand hierarchy, demand country, and usage.

As described above, embodiments of the present invention have been described, but those skilled in the art may add, change, delete, or add elements within the scope not departing from the spirit of the present invention described in the claims. The present invention may be modified and changed in various ways, etc., which will also be included within the scope of the present invention.

Claims (8)

(a) When the first heating temperature between 100 and 120 ℃ by heating the nasturtium vinegar, Hagocho, Eungseongcho, and wormwood in water to stop the heating, the heating is stopped, and then extracted by cooling to room temperature to obtain a first extract Doing;
(b) Changchang, Machihyeon, Sewao, Peppermint, Angelica, Baeksunpi, Seokchangpo, Cheongungpo, and Three hundred seconds in water, when heated to reach the second heating temperature between 70 ~ 90 ℃ by extracting while maintaining the second heating temperature Obtaining a second extract;
(c) mixing the first extract from which the solid is removed in step (a) and the second extract comprising the solid in step (b) and heating to reach a third heating temperature between 70 and 90 ° C .; Obtaining a third extract by extracting while maintaining the heating temperature;
(d) removing solids from the third extract and naturally cooling to room temperature, and then adding a nettle extract, red ginseng extract, and espinoglia extract to obtain a herbal extract; and
(e) adding a pH adjusting agent to the herbal extract to adjust the pH to 5 to 7 method for producing a composition for preventing hair loss or promoting hair growth. The method of claim 1,
Extraction time of step (a) is 3 to 10 hours,
Extraction time of the step (b) is a method for producing a composition for preventing hair loss or hair growth, characterized in that 1 to 60 minutes. The method of claim 1,
Extraction time of the step (c) is a method for producing a composition for preventing hair loss or hair growth, characterized in that 1 to 10 minutes. The method of claim 1,
The step (a) uses 20 to 30 parts by weight of Hannyeoncho, 10 to 15 parts by weight of Hagocho, 1 to 5 parts by weight of Echoseong, 1 to 5 parts by weight of persimmon soup and 1 to 5 parts by weight of wormwood;
The step (b) is Changja 20 to 30 parts by weight, gusset 10 to 15 parts by weight, sewage 10 to 15 parts by weight, mint 1 to 5 parts by weight, Angelica 1 to 5 parts by weight, ringworm skin 1 to 5 parts by weight, Seokchangpo 1 to 5 parts by weight, 1 to 5 parts by weight of cheongung and 1 to 5 parts by weight of 300 seconds, the method for producing a composition for preventing hair loss or promoting hair growth. The method of claim 1,
The step (d) is 10 to 15 parts by weight of the nettle extract, 10 to 15 parts by weight of red ginseng extract and 10 to 15 parts by weight of the episnozilia extract, the method for producing a composition for preventing hair loss or promoting hair growth. The method of claim 1,
The extraction time of step (a) is 6 to 7 hours;
The extraction time of step (b) is 25 to 35 minutes;
The extraction time of step (c) is 5 to 6 minutes;
The step (a) uses 18 to 22 parts by weight of Hannyeoncho, 10 to 12 parts by weight of Hagocho, 1 to 3 parts by weight of Echo, 1 to 3 parts by weight of persimmon soup and 1 to 3 parts by weight of wormwood;
The step (b) is Changja 18 to 22 parts by weight, gusset 10 to 12 parts by weight, sewage 10 to 12 parts by weight, mint 1 to 3 parts by weight, Angelica 1 to 3 parts by weight, ringworm skin 1 to 3 parts by weight, Seokchangpo 1 to 3 parts by weight, 1 to 3 parts by weight of uterus and 1 to 3 parts by weight of 300 seconds are used;
Step (d) uses 10 to 12 parts by weight of the nettle extract, 10 to 12 parts by weight of red ginseng extract, and 10 to 12 parts by weight of episnozilia extract;
The pH adjusting agent is a method for producing a composition for preventing hair loss or promoting hair growth, characterized in that citric acid. A composition for preventing hair loss or promoting hair growth prepared according to any one of claims 1 to 6. The method of claim 7, wherein
The composition is hair shampoo, hair conditioner, hair essence, hair oil, hair spray, hair aerosol, hair gel, cream, toner and soap any one of the form selected from the composition for preventing hair loss or promoting hair growth.