KR20120093607A - Oral liquid-type composition - Google Patents

Abstract

PURPOSE: A liquid composition containing Houttuynia cordata thunb (poly cordata Bueck) and green tea extract is provided to ensure excellent mouth cleansing and antibacterial functions. CONSTITUTION: A liquid composition for oral administration contains anti-caries agent which suppresses bacteria in oral cavity and cleanses mouth. The composition contains 0.35-0.75 wt% of thymol as an antibacterial agent, 0.5-2 wt% of eucalyptol as a sweetening agent, 0.1-0.6 wt% of benzoic acid as antiseptic, 0.5-2 wt% of citric acid as pH adjusting agent, 10-30 wt% of glycerin as a wetting agent, plant extract, and purified water. The plant extract includes green tea, Houttuynia cordata thunb (poly cordata Bueck), Houttuynia cordata Thunb, or Cnidium officinale extract.

Description

Oral liquid composition {Oral liquid-type composition}

The present invention relates to a liquid composition for oral cavity, and more specifically, oral liquid composition comprising three hundred seconds and green tea extract through oral cleaning in the mouth through the tangling reaction of the tannin component and saliva of the three hundred seconds and green tea extract It relates to providing a liquid composition for the oral cavity excellent in mouthwash and antibacterial power.

In general, bad breath is caused by decomposing enzymes or amino acids in the oral cavity of proteins, food residues, and the like, which are produced by decomposition of deodorizing enzymes or amino enzymes to produce odor-inducing substances. The main components that cause bad breath are volatile sulfides, and these volatile compounds include hydrogen sulfide, methyl mercaptan, dimethyl mercaptan, and the like. In addition to these volatile sulfides, volatile amine compounds such as triethylamine, aldehydes, fatty acids, ammonia and the like.

Therefore, recently, commercially available gargles are manufactured and provided for frequent use for cleanliness after eating or in the mouth, and recently, in order to increase the antiseptic power for preventing the antibacterial and inflammation in the oral cavity, for example, benzenetonium chloride and zinc chloride. Or goggle products containing various herbs, anti-plasmin agents, allantoin derivatives, etc. have been developed and partially produced, but the situation is not getting the effect as expected.

Accordingly, the present invention has an object of the present invention to provide a liquid composition for oral cavity containing tannin component which is convenient and practical, but not abrasive, and has high antibacterial and antifungal properties against oral microorganisms in view of the problems of the prior art.

More specifically, the present application is to provide a liquid composition for oral cavity, a fluorine compound as a caries preventive agent, a vegetable extract containing tannin component as a bacterial inhibitor, and a liquid composition for oral cavity based on pure water as a diluent. Has a purpose.

The composition of the present invention is to suppress the bacteria in the oral cavity, in the liquid composition for oral cavity containing caries preventive agent, antimicrobial agent, sweetening agent, flavoring agent, preservative, pH adjusting agent, wetting agent, vegetable extract and purified water contained to perform the cleaning action,

The vegetable extract provides a liquid composition for oral cavity, characterized in that containing at least one selected from green tea extract, three hundred vine extract, fish vinegar extract, cheongung extract.

On the other hand, the caries preventive agent contains 0.5 to 2% by weight of sodium fluoride, 0.05 to 0.2% by weight of sodium chloride, respectively

The antimicrobial agent contains 0.35 to 0.75 wt% of thymol,

The sweetener contains 0.5-2% by weight of eucapititol,

The fragrance is selected and contained one or more of 0.3 to 0.9% by weight of methyl silicic acid, 0.05 to 0.2% by weight of menthol, 0.05 to 0.3% by weight of xylitol and 0.05 to 0.3% by weight of spearmint,

The preservative contains 0.1 to 0.6% by weight of benzoic acid,

The pH adjuster contains 0.5 to 2% by weight citric acid,

The wetting agent contains 10 to 30% by weight of glycerin,

The vegetable extract contains 5 ~ 20% by weight of green tea extract, 0.1 ~ 0.5% by weight of three hundred seconds extract, 0.1 ~ 0.5% by weight fish extract and 0.05 ~ 0.2% by weight of uterine extract,

The purified water provides a liquid composition for household use, characterized in that made by containing the remaining weight% of each component.

On the other hand, persimmon leaf extract 0.1 to 0.5% by weight, the mulberry leaf extract 0.1 to 0.5% by weight to the vegetable extract provides a liquid composition for oral cavity, characterized in that it further comprises.

On the other hand, the liquid composition for oral cavity provides a liquid composition for oral cavity, characterized in that it is commercialized to be any one of toothpaste, oral spray, mouthwash, mouthwash, and chewing gum.

The liquid composition for oral cavity of the present invention described above contains green tea extract, triticale extract, fish vinegar extract, and celery extract, which are vegetable extracts containing tannin, which inhibits bacteria in the oral cavity and is excellent in removing bad breath. As a liquid composition for oral administration, it contains a sweetening agent and an antimicrobial agent, which not only reduces the irritation in the oral cavity and enhances the refreshing feeling. There is.

1 is a diagram of the strain stained with Streptococcus mutans strain according to the present invention.
Figure 2 is a diagram inoculated Streptococcus mutans strain in the provided saliva according to the present invention.
Figure 3 is an initial inoculation of Streptococcus mutans strain after mixing Composition D in a provided saliva according to the present invention.
Figure 4 is a foreign material is produced after inoculating the Streptococcus mutans strain after mixing the composition D in the provided saliva according to the present invention.
5 is a view showing that foreign substances are produced after inoculating a Streptococcus mutans strain after mixing Composition D with a provided saliva according to the present invention.
Figure 6 is a test report showing the antimicrobial test composition D according to the present invention.

In order to achieve the above object will be described in detail through the following detailed description.

The composition of the present invention is to suppress the bacteria in the oral cavity, and in the liquid composition for oral cavity containing caries preventive agent, antibacterial agent, sweetener, flavoring agent, preservative, pH adjuster, wetting agent, vegetable extract and purified water contained to perform the cleaning action, Vegetable extract provides a liquid composition for oral cavity, characterized in that it contains at least one selected from green tea extract, three hundred vine extract, fish vinegar extract, cheongung extract.

The green tea extract is a natural compound extracted from the leaves of green tea (epigallocatechin gallate), epigallocatechin (epigallocatechin), epicatechin gallate (epicatechin gallate), epicatechin (epicatechin), and It is composed of five main ingredients, tannins, such as catechin. This tannin component is known as a compound having various and beneficial functions for the human body such as antioxidant activity, ultraviolet absorption effect, antihistamine action, harmful oxygen removal, whitening effect, anti-aging, anticancer effect.

The manufacturing method of the green tea extract from the tannin component contained in the green tea may be prepared according to a conventional method of extracting an active ingredient from a plant. For example, a finely cut tea leaf may be water or a polar organic solvent alone or these. It can be prepared by adding a mixture of and dipping or heating at a suitable temperature for a certain time to obtain a green tea extract, then filtered and the filtrate is concentrated under reduced pressure.

To explain this in detail, to prepare green tea extract, put 10-15 times the amount of water in 1 kg of dried green tea leaves, heated at 80 to 100 ℃ for 2 to 3 hours and then filtered with a nylon filter of 10 ㎛, this filtration The liquid was concentrated under reduced pressure with a vacuum thin layer plate evaporator at 60 to 70 ° C. to obtain about 250 g of green tea extract.

The trichophytium extract is extracted from a plant called Houttuynia cordata thunb (poly cordata Bueck), and the trichophytium is a perennial herb with a plant height of 15 to 30 cm, with egg or heart-shaped leaves alternately attached, and flower spikes on the stem. Four white weaves are in the shape of ten crosses under the spikelets of small yellow flowers, growing mainly in the low mountains, fields, and wetlands of the central and southern regions. It is this grass that grows well, and the stem and leaves of the plant are used.

Main components are methylnonylkenone CH3 (CH2) 8COCH3 (oxidation product of decanoyl acetaldehyde), myrcene (C10H16), laurin aldehyde (C11H23CHO), caprinaldehyde (C 9H19CHO), capric acid and water-soluble tannins There are a large number of ingredients, and the leaves contain quercitrin and minerals that are released in water. Cuercitrin has urinary action (100,000 times concentration) and cardiac action, and Escherichia coli, typhoid, paratyphoid, lycobacteria, It has antibacterial and capillary potentiating effects against gonococci, staphylococcus aureus and filamentous fungi.Decanoyl acetaldehyde has antibacterial action against non-pathogenic fungi, as well as ringworm and athlete's foot fungi. The antimicrobial activity against 1: 40,000 is stronger than sulfa, and the water-soluble tannins act to release toxic substances in the body.

In order to extract the three hundred seconds, the three hundred seconds extract using the active ingredient in the same way as the green tea extract.

The trichophytium extract of the present invention reacts with the oral saliva due to the water-soluble tannin component, causing entanglement, and dispersing up to a small space in the oral cavity to remove bacteria including toxic substances in the oral cavity and to suppress bacterial propagation.

In addition, the Echochocho extract is extracted by using a plant called Echochocho (Houttuynia cordata Thunb) contains the active ingredient in the entire leaf, stem, root, bioactive substances including a unique unique smell to help metabolism blood It clears and promotes kidney function, inflammatory symptoms and excretion of body toxins, and has been widely used as a folk medicine in China and Japan since the past 3000 years ago. It is used for boils, detoxification, arthritis, inflammatory diseases and skin diseases. The main ingredients are essential oils such as decanoyl acetaldehyde, melon and myrsen. Of these, "decanoyl acetaldehyde" has a titer of 40,000 times that of "sulfamine" antibiotics. .

Thus, in order to extract the eochochocho to use the eochochocho extract extracted the active ingredient in the same manner as the green tea extract.

Echochocho extract of the present invention by inhibiting the melanin production of gums in the oral cavity provides a whitening effect to prevent pigmentation and excellent effect in removing tartar of teeth.

Cnidium officinale is a perennial herb, 40-70 cm in height, and has a characteristic scent of plants. The root of the uterus is an irregular nodular lump, 2-7 cm in diameter, yellowish brown with coarse wrinkles, several parallel raised bumps, and a top of the concave circular stem trace. Its cross section is yellowish white or greyish yellow with scattered yellowish brown oil and the formation layer is wavy yellowish gate. The root of Cheongung is used for various gynecological diseases such as cold syndrome, anemia and dysmenorrhea disorder with the aim of blood, tonic, soothing and pain relief in oriental medicine.

The uterine extract used in the present invention can be obtained by using various organs, tissues (for example, roots, leaves, flowers, stems, fruits and seeds, etc.) of the uterus. use.

The uterine extract of the present invention inhibits the activity of melanocyte stimulating hormone of the gums in the oral cavity, and this property results in a whitening effect of preventing pigmentation by inhibiting the production of tyrosinase and inhibiting melanin production.

On the other hand, the caries preventive agent contains 0.5 to 2% by weight of sodium fluoride, 0.05 to 0.2% by weight of sodium chloride, the antimicrobial agent contains 0.35 to 0.75% by weight of thymol, the sweetener contains 0.5 to 2% by weight of eucapitol The fragrance is selected from 0.3 to 0.9% by weight of methyl silicic acid, 0.05 to 0.2% by weight of menthol, 0.05 to 0.3% by weight of xylitol and 0.05 to 0.3% by weight of spearmint, and the preservative is 0.1 to Benzoic acid. 0.6 wt%, the pH adjuster contains 0.5 to 2% by weight citric acid, the wetting agent contains 10 to 30% by weight of glycerin, the vegetable extract is 5 to 20% by weight of green tea extract, 0.1 to 300 seconds extract It contains 0.5% by weight, fish extract 0.1-0.5% by weight and the cheongung extract 0.05-0.2% by weight, respectively, the purified water provides a liquid composition for the old house containing the remaining weight% of the respective components.

Next, the composition shown in Table 1 was mixed to prepare a liquid composition for oral cavity, and each of the vegetable extracts used the concentrate obtained through the same process as the green tea extract described above.

division Content (% by weight) A B C D Tooth decay prevention Sodium fluoride 1.0 1.0 1.0 1.0 Sodium chloride 0.1 0.1 0.1 0.1 Antibacterial agents Thymol 0.64 0.64 0.64 0.64 Sweetener Eucapititol 1.0 1.0 1.0 1.0 Spices Methylsilic acid 0.6 0.6 0.6 0.6 menthol 0.1 0.1 0.1 0.1 Xylitol 0.15 0.15 0.15 0.15 Spearmint 0.15 0.15 0.15 0.15 antiseptic Benzoic acid 0.3 0.3 0.3 0.3 pH regulator Citric acid 1.0 1.0 1.0 1.0 Wetting agent glycerin 20 20 20 20 Vegetable extract Green tea extract 10 10 10 10 Three hundred sec extract - 0.2 0.2 0.2 Eoseongcho Extract - - 0.2 0.2 Cheonung Extract - - - 0.1 Purified water - to 100 to 100 to 100 to 100 synthesis 100 100 100 100 pH 4.02 3.87 3.61 3.53

Experimental Example 1: Clinical comparison experiment on the effect of bad breath

Comparative experiments were performed using the liquid composition for oral cavity prepared with the composition of Table 1 shown in the above example.

1) Subject

Fifty men and women in their twenties with no dental caries were selected and five subjects were treated per liquid composition for oral cavity.

2) Experiment Method

Taste was used according to the test subjects' preferences, and the higher the score was, the better the score was.

Refreshing after using the subject was given a meal of the same diet 30 minutes after the subject was allowed to gargle for 30 seconds with the liquid composition for oral subjects, and then was performed by the preference of the refreshing feeling remaining in the mouth. The higher the score, the better the freshness of the mouth.

The amount of coagulant produced after use was measured by visual observation of the resultant spit after giving the subject a meal of the same diet for 30 minutes and then gargled for 30 seconds with the liquid composition for oral treatment. It was determined that the higher the score, the higher the score was, the higher the amount of coagulant produced.

After use, bad breath is removed from the oral environment management for 24 hours after giving the subjects a meal of the same diet, and then paired with 5 persons each for 30 seconds before the following of the oral liquid composition and the target oral liquid composition 1 The odor removal was performed according to the subjects' preference after the gargles twice and twice, and it was determined that the higher the score, the higher the score, the higher the bad breath removal effect.

3) Experiment result

The results of clinical comparative experiments on the effects of bad breath are shown in Table 2 below.

division A B C D tube
Twill
sword
four flavor 2.10 2.70 3.10 4.10 Refreshing 2.30 2.80 3.50 4.50 Bad breath 2.15 3.10 3.10 4.60 Tooth stimulation 2.70 3.30 3.60 4.10 Sum 9.25 11.9 13.3 17.3

As shown in Table 2, in the case of C, D, preference, bad breath removal, and the like were excellent. In particular, the green tea extract, three hundred vine extract, fish vinegar extract and cheonung extract of the plant product used in combination with D can be seen that the effect is better.

In case of A, the scores of the preference and bad breath removal were low after goggle, and these results showed that the tannin component contained in the green tea extract showed less stringency against the saliva, which was a small amount of tannin component contained in the green tea extract. It seems to be due to. In case of B, bad breath removal and tooth stimulation were excellent, but the preference was not good due to the strong taste of green tea extract and three hundred sec extract, which is attributed to the high content of tannin.

In view of the above results, it can be seen that the liquid composition for the oral cavity of the present invention combines the effects of preference, bad breath removal, etc., and the effect is excellent.

Experimental Example 2 Experiment for Antibacterial Effect

(1) Antibacterial activity measurement of liquid composition (liquid type) for oral cavity

Comparative experiments were performed using the liquid composition for oral cavity prepared with the composition of Table 1 shown in the above example. Streptococcus mutans was used as oral bacteria, and cultured by liquid culture and paper disk methods.

1) Liquid Culture

The oral bacterium Streptococcus mutans KCTC 3298 was distributed by the Korea Food Research Institute to measure the inhibitory effect on oral bacteria. The cultured strains were subjected to anaerobic culture at 35 ° C. for 24 hours by liquid culture, followed by activation to tertiary culture, and used in experiments. Antimicrobial activity evaluation was performed by investigating the inhibitory power by the liquid culture method. S. mutans were grown using a brain heart infusion (BHI) solid medium.

Strains were inoculated with the provided saliva and the compositions A, B, C, D shown in Table 1 in a ratio of 1: 3. Subsequently, inoculation of the strain without addition of the above composition to the saliva provided for comparison was performed by shaking for 1 minute (vortexing) as a control.

After incubation at 35 ° C. for 24 hours, the absorbance of the liquid culture solution was measured at 660 nm, and the inhibitory power was calculated by Equation 1 below.

[Equation 1]

% Inhibition = [(control O.D.-treatment O.D.) / (Control O.D.)] × 100

2) Paper Disc Act

The oral bacterium Streptococcus mutans KCTC 3298 was distributed by the Korea Food Research Institute to measure the inhibitory effect on oral bacteria. The cultured strains were activated by anaerobic culture in a liquid culture method and then used in experiments.

Antibacterial activity was performed by measuring the inhibitory power by the paper disk method. Specifically, by using a BHI (brain heartinfusion) solid medium, the cultured cells were diluted to a final cell number of 1 × 10 ⁶ cells / ml and inoculated in a solid medium by 100 μl to observe the growth results by , The antimicrobial activity of the liquid composition for oral cavity according to the present invention was measured.

After incubation at 35 ° C. for 24 hours, the diameter of the transparent disk of the paper disk (including 8 mm of the diameter of the paper disk) was expressed. The results are shown in Table 3 below.

division A B C D Concentration (μl) 0 100 0 100 0 100 0 100 Liquid culture method % Inhibition - 40.2 - 71.8 - 78.6 - 88.6 Paper Disc Method Transparent band (mm) - - - 3 - 4 - 5

As shown in Table 3, when the composition contains only green tea extract [composition A] antibacterial activity, it can be confirmed that the antimicrobial activity increases when the green tea extract, three hundred vine extract, fish vinegar extract and cheongak extract.

1 is a diagram showing the staining of the stock solution of Streptococcus mutans strain and the stock solution, Figure 2 is a diagram showing the inoculation of the Streptococcus mutans strain in the saliva provided, Figure 3 is mixed with the provided saliva and composition D Inoculation of Streptococcus mutans strains showing bacterial infections (coagulants) around oral epithelial cells, FIG. 4 is inoculated with Streptococcus mutans strains of FIG. 3 to coagulate around oral epithelial cells over time. FIG. 5 is a view in which water is formed, and FIG. 5 shows a diagram in which coagulum is formed and solidified around oral epithelial cells over time by inoculating the Streptococcus mutans strain of FIG. 3.

(2) Antibacterial activity measurement of liquid composition (liquid type) for oral cavity

The bactericidal effect of the stock solution of the sample shown in Example 1 (D) was tested using Streptococcus mutans as a positive bacterium. The test strain was inoculated into 20 mL of the stock solution of the sample, and left at room temperature for 30 seconds for 1 minute.

Under these test conditions, the test results of the requested sample showed a bactericidal effect of at least 99.9% after 30 seconds and at least 99.9% after 1 minute.

The strain used for the test was Streptococcus mutans ATCC 25175, and the medium was Nutrient Broth (DIFCO, USA), Nutrientagar (DIFCO, USA), Tryptic Soy Agar (DIFCO, USA), D / E Neutralizing Broth (DIFCO, USA) and physiology. Saline solution.

After culturing the strain in a liquid medium, the cultured bacteria were diluted and adjusted to an initial bacterial count of 1 to 9 X 10 ⁵ CFU / mL. The test bacteria were added to 20 mL of the test solution (stock solution), mixed, and allowed to stand at room temperature for 30 seconds and 1 minute, followed by measuring the number of live bacteria. The number of viable cells was measured with the saline solution as a control, and the number of initial bacteria was expressed.

In this case, the initial dilution of all experiments was performed by neutralizing with D / E Neutralizing Broth (DIFCO). When bacteria were grown in the medium, the number of bacteria on the medium was multiplied by the dilution factor. In the case of the growth of bacteria in the multiplied by the dilution factor made in the neutralization step was expressed as "less than 10 (<10)". The bacterial counts at all stages were measured using TSA, and the viable cell count was determined according to Equation 2 below, and the sterilization reduction rate was determined according to Equation 3 below.

&Quot; (2) &quot;

N = C X D

N is the number of viable cells, C is the number of colonies (mean number of two colonies), and D is the dilution factor (dilution factor of diluent).

&Quot; (3) &quot;

R (%) = [(A-B) / A] X 100

R is a sterilization reduction rate, A is the initial bacterial count, and B represents the bacterial count after a certain time.

Sterilization Result Early 30 seconds later 1 minute later Number of bacteria (CFU / mL) 3.4 X 10 ⁵ <10 <10 Sterilization Reduction (%) > 99.9 > 99.9

The results for the S. mutants showed that the initial inoculum was reduced from 3.4 × 10 ⁵ CFU / mL to <10 CFU / mL after 30 seconds and to <10 CFU / mL after 1 minute.

As a result of the sterilization test on the stock solution of the liquid composition sample for oral cavity of the present invention, the bactericidal effect of the Gram-positive bacterium S. mutance was 99.9% after 30 seconds, and after 1 minute, it showed a 99.9% or more bactericidal effect. This test result analysis was proved through a test report certified in FIG.

And the remaining part in the state containing each of the above components is filled with purified water, preferably contains 10 to 50% by weight of purified water, such as mineral distilled water or pure bottled water.

On the other hand, persimmon leaf extract 0.1 to 0.5% by weight, the mulberry leaf extract 0.1 to 0.5% by weight to the vegetable extract provides a liquid composition for oral cavity, characterized in that it further comprises.

Persimmon leaves are mainly composed of tannins, tannins are heat-stable and have very high hydrophilic phenolic hydroxyl groups, making them easily gelled at high concentrations, and polymers such as hydrogen bonds and non-covalent bonds. It has various reactivity such as forming a bond or complex. Persimmon leaf tannin is a typical condensed tannin mixture and consists of 1: 1: 2: 2 catechin, catechin-3-gallate, gallocatechin, and gallocatechin-3-gallate, respectively. However, in addition to these components, it is reported that a large amount of substances having various structures and various terminal residues belonging to the proanthocyanidin group are reported.

When the persimmon leaf extract phosphorus is mixed to increase the intracellular transmission and residual effect provides excellent plaque formation inhibitory effect and gingival inflammation relieving effect.

In addition, mulberry leaves contain about 50 kinds of minerals, 21 kinds of amino acids, and 59 kinds of organic ingredients through material analysis of mulberry leaves in Korea, Japan and China, and prevent and cure adult diseases and modern diseases. It is found that the functional food ingredients, among the components of the mulberry leaves (Gamma-Amino Butyric Acid), alanine (alanine), asparagine (asparagine), tyronsin (tyronsin), serine (serine), rutin (rutin), water-soluble tannin, It contains components such as calcium, iron and potassium.

In the present invention, by using the water-soluble tannin component contained in the mulberry leaves will be used to have the same effect as the green tea extract.

On the other hand, the seaweed extract further comprises 0.1 to 0.5% by weight of the seaweed extract is extracted only sodium alginate (Na-Alginate), in the case of such sodium alginate, brown algae, Echinacea, rhubarb, seaweed, It is a compound having alginic acid contained in kelp and the like.

In the case of the sodium alginate (Na-Alginate), it is a component contained in brown seaweed, E. coli, E. coli, Rhubarb, Seaweed, kelp, etc., alginic acid. The nature of the acid appears in. It can be rectified in acidic solution, Na + ionized in alkaline solution, evaporated, dried and differentiated into powder. The polymer unit molecule carboxyl group (-COO-) of the alginate salt is ion-polymerized with a divalent cation material such as Ca ++, Cu ++, Mn ++, Co ++, Fe ++, Zn ++ to form a new polymer that has changed to a gel shape.

By including sodium alginate, which is a natural material, in the liquid composition for oral cavity, it is possible to further exhibit caries prevention and sterilization effect.

On the other hand, the liquid composition for oral cavity provides a liquid composition for oral cavity, characterized in that it is commercialized to be any one of toothpaste, oral spray, mouthwash, mouthwash, and chewing gum.

In addition, the present invention described above is not limited to the above-described embodiments, and various substitutions, modifications, and changes can be made without departing from the technical spirit of the present invention. It will be apparent to those who have knowledge.

Claims (5)

In the liquid composition for oral cavity containing the tooth decay prevention agent, antibacterial agent, sweetener, fragrance, preservative, pH adjusting agent, wetting agent, vegetable extract and purified water which contain bacteria in the oral cavity and perform the cleaning action,
The vegetable extract is a liquid composition for oral cavity, characterized in that containing at least one selected from green tea extract, three hundred vine extract, fish vinegar extract, cheongung extract. According to claim 1, The caries preventive agent contains 0.5 to 2% by weight sodium fluoride, 0.05 to 0.2% by weight sodium chloride, respectively
The antimicrobial agent contains 0.35 to 0.75 wt% of thymol,
The sweetener contains 0.5-2% by weight of eucapititol,
The fragrance is selected and contained one or more of 0.3 to 0.9% by weight of methyl silicic acid, 0.05 to 0.2% by weight of menthol, 0.05 to 0.3% by weight of xylitol and 0.05 to 0.3% by weight of spearmint,
The preservative contains 0.1 to 0.6% by weight of benzoic acid,
The pH adjuster contains 0.5 to 2% by weight citric acid,
The wetting agent contains 10 to 30% by weight of glycerin,
The vegetable extract contains 5 ~ 20% by weight of green tea extract, 0.1 ~ 0.5% by weight of three hundred seconds extract, 0.1 ~ 0.5% by weight fish extract and 0.05 ~ 0.2% by weight of uterine extract,
The purified water composition of claim 1, wherein the purified water is contained by the remaining weight% of each component. The liquid composition for oral cavity according to claim 1, wherein the vegetable extract further comprises one or more selected from 0.1 to 0.5% by weight of persimmon leaf extract and 0.1 to 0.5% by weight of mulberry leaf extract. The liquid composition for oral cavity according to claim 1, further comprising 0.1 to 0.5% by weight of seaweed extract in the vegetable extract. The liquid composition for oral cavity according to any one of claims 1 to 4, wherein the liquid composition for oral cavity is commercialized as one of toothpaste, oral spray, mouthwash, mouthwash, and chewing gum.

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