CN106924162A - A kind of application of plant additive, bacteriostatic agent, oral care product and plant additive in oral care product is prepared - Google Patents
A kind of application of plant additive, bacteriostatic agent, oral care product and plant additive in oral care product is prepared Download PDFInfo
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- CN106924162A CN106924162A CN201710188477.0A CN201710188477A CN106924162A CN 106924162 A CN106924162 A CN 106924162A CN 201710188477 A CN201710188477 A CN 201710188477A CN 106924162 A CN106924162 A CN 106924162A
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- 230000000996 additive effect Effects 0.000 title claims abstract description 60
- 239000000654 additive Substances 0.000 title claims abstract description 59
- 239000000022 bacteriostatic agent Substances 0.000 title claims abstract description 29
- 241000196324 Embryophyta Species 0.000 claims abstract description 63
- 239000000284 extract Substances 0.000 claims abstract description 43
- 239000000419 plant extract Substances 0.000 claims abstract description 36
- 244000119298 Emblica officinalis Species 0.000 claims abstract description 22
- 235000015489 Emblica officinalis Nutrition 0.000 claims abstract description 22
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims abstract description 21
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 21
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims abstract description 21
- 241000241413 Propolis Species 0.000 claims abstract description 21
- 229940094952 green tea extract Drugs 0.000 claims abstract description 21
- 235000020688 green tea extract Nutrition 0.000 claims abstract description 21
- 229940010454 licorice Drugs 0.000 claims abstract description 21
- 229940069949 propolis Drugs 0.000 claims abstract description 21
- 239000002994 raw material Substances 0.000 claims abstract description 20
- 229940105902 mint extract Drugs 0.000 claims abstract description 18
- 241000202807 Glycyrrhiza Species 0.000 claims description 20
- 229940034610 toothpaste Drugs 0.000 claims description 18
- 239000000606 toothpaste Substances 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 14
- 239000002324 mouth wash Substances 0.000 claims description 13
- 229940051866 mouthwash Drugs 0.000 claims description 13
- 238000009472 formulation Methods 0.000 claims description 8
- 244000246386 Mentha pulegium Species 0.000 claims description 4
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 4
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 4
- 235000001050 hortel pimenta Nutrition 0.000 claims description 4
- 241000256844 Apis mellifera Species 0.000 claims 1
- 239000003292 glue Substances 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 abstract description 12
- 230000000740 bleeding effect Effects 0.000 abstract description 11
- 210000002200 mouth mucosa Anatomy 0.000 abstract description 9
- 241000894006 Bacteria Species 0.000 abstract description 8
- 230000001954 sterilising effect Effects 0.000 abstract description 8
- 230000008439 repair process Effects 0.000 abstract description 7
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 2
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- 230000000694 effects Effects 0.000 description 25
- 238000002360 preparation method Methods 0.000 description 10
- 208000025157 Oral disease Diseases 0.000 description 8
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- 238000002474 experimental method Methods 0.000 description 8
- 230000036541 health Effects 0.000 description 8
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- 241000588724 Escherichia coli Species 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 230000006872 improvement Effects 0.000 description 5
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- 230000000452 restraining effect Effects 0.000 description 4
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- 230000009286 beneficial effect Effects 0.000 description 3
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- 241000238631 Hexapoda Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
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- 239000004480 active ingredient Substances 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
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- 239000003995 emulsifying agent Substances 0.000 description 2
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- 241001478240 Coccus Species 0.000 description 1
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- 241000191940 Staphylococcus Species 0.000 description 1
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- 230000000202 analgesic effect Effects 0.000 description 1
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- 230000008901 benefit Effects 0.000 description 1
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- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000013499 data model Methods 0.000 description 1
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- 230000008030 elimination Effects 0.000 description 1
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- 239000004088 foaming agent Substances 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to oral care product technical field, there is provided a kind of application of plant additive, bacteriostatic agent, oral care product and plant additive in oral care product is prepared.Plant additive, including at least three kinds separable plant extracts each other, plant extracts are selected from green-tea extract, mint extract, emblic extract, licorice and propolis extract.The additive effect is comprehensive.Bacteriostatic agent, is made up of above-mentioned plant additive.The bacteriostatic agent has good sterilized sterilization functions.The plant additive can be applicable in preparing oral care product.Oral care product, is made up of raw material, and raw material includes above-mentioned plant additive, and plant additive mass percent in the feed is 5.2%~42%.The oral care product can not only prevent bleeding gums, repair oral mucosa, eliminates oral peculiar smell, but also can kill the various bacteriums in oral cavity.
Description
Technical field
The present invention relates to oral care product technical field, in particular to a kind of plant additive, bacteriostatic agent, mouth
The application of chamber care product and plant additive in oral care product is prepared.
Background technology
With the improvement of people's living standards, increasing people's concern oral health, it is understood that oral health is very
Important, oral health care products the more commonly used at present mainly have following a few classes：Toothpaste：Toothpaste is commonly used in daily life
Cleaning supplies, with continuing to develop for science and technology, technological equipment is updated and perfect, and various types of toothpaste ask in succession
Generation, the quality and class of product are improved constantly, and present toothpaste variety by single clean type toothpaste, develops into kind neat
Entirely, it is vdiverse in function, the up to a hundred Mobyneb toothpaste of brand, the need for meeting the different levels level of consumption.Mouthwash：It is more next
More people promote oral health, water energy of gargling cleaning oral cavity, pre- anti-caries and periodontitis etc. using mouthwash.Mouthspray：
With clearing heat and detoxicating, effect of anti-inflammatory analgetic.
However, at present, effect of these oral care products is all relatively simple, goes out in particular for general prevention and treatment gum
Blood, repairs oral mucosa, eliminates oral peculiar smell, and kill the aspects such as oral bacteria.Therefore, a kind of full-featured mouth is developed
Chamber care product becomes current problem demanding prompt solution.
The content of the invention
The first object of the present invention is to provide a kind of plant additive, and the additive effect is comprehensive.
The second object of the present invention is to provide a kind of bacteriostatic agent, and the bacteriostatic agent has good sterilized sterilization functions.
The third object of the present invention is the application for providing a kind of plant additive in oral care product is prepared.
The fourth object of the present invention is to provide a kind of oral care product, and the oral care product can not only prevent tooth
Oulorrhagia, reparation oral mucosa, elimination oral peculiar smell, but also the various bacteriums in oral cavity can be killed.
The present invention is solved its technical problem and is realized using following technical scheme：
A kind of plant additive, including at least three kinds separable plant extracts each other, plant extracts are selected from green tea
Extract, mint extract, emblic extract, licorice and propolis extract.
A kind of bacteriostatic agent, is made up of above-mentioned plant additive.
A kind of application of above-mentioned plant additive in oral care product is prepared.
A kind of oral care product, is made up of raw material, and raw material includes above-mentioned plant additive, and plant additive is in the feed
Mass percent be 5.2%~42%.
A kind of plant additive, bacteriostatic agent, oral care product and the plant additive that the present invention is provided are preparing mouth
The beneficial effect of the application in the care product of chamber is：
The plant additive that the present invention is provided includes at least three kinds separable plant extracts each other, plant extracts tool
There is pure natural function, it is harmless；At least three kinds be set with is beneficial to promote the function of obtained plant additive more complete
Face；Separable being set with can be added in other products beneficial to obtained plant additive in wider form each other,
Extend its range of application；Plant extracts is selected from green-tea extract, mint extract, emblic extract, licorice
And propolis extract, above several plant extract is respectively provided with natural restraining and sterilizing bacteria ability, and each plant extracts mutually it
Between can play coordinated effect, play more fully hereinafter protection and health care effect.
The bacteriostatic agent that the present invention is provided, is made up of above-mentioned plant additive, because the plant additive tool that the present invention is provided
There is good restraining and sterilizing bacteria function, therefore can based on this be made the bacteriostatic agent with good restraining and sterilizing bacteria function.
Application of the plant additive that the present invention is provided in oral care product is prepared, the plant addition that the present invention is provided
Agent is pure natural, harmless, and with the comprehensive function of multiple-effect, therefore can apply in oral care product is prepared.
The oral care product that the present invention is provided, is made up of raw material, and raw material includes above-mentioned plant additive, plant additive
Mass percent in the feed is 5.2%~42%.Plant additive is tried in the content of oral care product by creative
Test and obtain, in the range of the mass percent, obtained oral care product prevent bleeding gums, repair oral mucosa, disappear
Removing abnormal flavor in oral cavity, and restraining and sterilizing bacteria best results.
Specific embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below will be in the embodiment of the present invention
Technical scheme be clearly and completely described.Unreceipted actual conditions person, builds according to normal condition or manufacturer in embodiment
The condition of view is carried out.Agents useful for same or the unreceipted production firm person of instrument, are the conventional product that can be obtained by commercially available purchase
Product.
Plant additive following to the embodiment of the present invention, bacteriostatic agent, oral care product and plant additive are in system
Application in standby oral care product is specifically described.
Plant additive provided in an embodiment of the present invention, including plant extracts.Plant extracts be with plant as raw material,
The need for purposes according to the final products to extracting, separation process is extracted by physical chemistry, orientation is obtained and concentration plant
In a certain kind or plurality of active ingredients, the product formed without changing its active ingredient structure, plant extracts is natural, right
Human body is harmless, is particularly suitable for playing health-care assistance effect as additive.
It should be noted that the species of plant extracts is not particularly limited, it is contemplated that in order that obtained plant is added
The function of agent is more comprehensive, in this embodiment, it is preferred that, plant extracts is at least three kinds.
Combination between various plants extract is not particularly limited, in the present embodiment, it is contemplated that, plant additive was both
Direct effect can be carried out to human body as entirety, have to be added in other products as additive human body is made indirectly
With, it is preferable that be can be separated between various plant additives.
The selection of plant extracts is not particularly limited, and every plant extracts that can play antibacterial and bacteriostasis all should
It is included, in the present embodiment, preferably, plant extracts is selected from green-tea extract, mint extract, emblic and carries
Take thing, licorice and propolis extract.
Green-tea extract is the active component extracted from green tea blade, mainly including Tea Polyphenols (catechin) etc..Have
The effects such as disinfecting detoxifying, anti-oxidant, removing free radical, detoxicating and raising immunity of organisms；Mint extract has fragrant pure and fresh
Pleasant fragrance；Emblic extract has removes free radical and oxidation resistant effect；Licorice has anti-inflammatory and resists exempts from
Epidemic disease, it is clearing heat and detoxicating, and skin whitening effect；Propolis extract has various functions such as antibacterial, anti-inflammatory, antipruritic, anti-oxidant.
Above several plant extract can play coordinated effect each other, can more fully hereinafter play protection
With effect of health care.
It should be noted that the formulation of any of the above plant extracts is not specifically limited, including pulvis, tablet, paste
Deng in the present embodiment, it is contemplated that be easy to easily be measured when easily packing or be added separately during unified sale, therefore its formulation
It is identical.Compared to other formulations, pulvis is easier to carry, and addition is also easier to as additive, therefore in the present embodiment, it is excellent
Selection of land, using pulvis.
Bacteriostatic agent provided in an embodiment of the present invention, is made up of plant additive provided in an embodiment of the present invention.
In embodiments of the present invention, bacteriostatic agent can in plant additive various plants extract be combined together it is laggard
Sold together after row sale, or various plants extract independent packaging.
In embodiments of the present invention, in order to improve antibacterial effect, in the present embodiment, preferably, bacteriostatic agent bag
Include green-tea extract, mint extract, emblic extract, licorice and propolis extract.
It should be noted that green-tea extract, mint extract, emblic extract, licorice and propolis are carried
The proportioning consumption for taking thing is not particularly limited, in the present embodiment, in order to reach optimal antibacterial bacteriostatic effect, by inventor
Creativeness experiment draws, counts by weight, green-tea extract 0.5-5.5 parts, mint extract 6.5-8.5 parts, emblic carries
Take thing 0.5-1.5 parts, licorice 1.5-2.5 parts and propolis extract 0.5-5.5 parts.
Inventor is by creative experiment discovery, this plant additive provided in an embodiment of the present invention, not only with good
Good antibacterial and bacteriostasis, and have significantly to preventing and treating bleeding gums, repairing oral mucosa and eliminating oral peculiar smell etc.
Effect, therefore, the plant additive can be applied in oral care product is prepared.
A kind of oral care product provided in an embodiment of the present invention, the product is made up of raw material, in order to obtain good controlling
Bleeding gums are treated, the oral health benefits such as oral mucosa, antibacterial bacteriostatic are repaired, raw material includes plant provided in an embodiment of the present invention
Additive.
The addition of plant additive is not particularly limited, and in embodiments of the present invention, the creative experiment of inventor draws,
When plant additive mass percent in the feed is 5.2%~42%, preferably above-mentioned oral health effect can be obtained
Really, when the mass percent especially when plant additive in the feed is 6.5%~42%, the above-mentioned oral health effect of acquirement
It is really best.
Plant additive adds the mode of raw material to be not particularly limited, it is contemplated that is easy to precise and calculates consumption, excellent
Selection of land, sequentially adds after the plant extracts in plant additive is weighed.
In the present embodiment, the species of oral care product is not particularly limited, it is contemplated that the product of preparation needs utilization rate
It is higher, preferably by toothpaste, mouthwash and mouthspray.
When oral care product is toothpaste, the creative experiment of inventor show that by mass percentage, raw material includes：
0.5%~5% green-tea extract, 2.5%~5% mint extract, 1.2%~2% emblic extract, 0.5%
~5% licorice, during 0.5%~5% propolis extract, the oral health benefits that it mitigates bleeding gums etc. are most
It is good.
When oral care product is mouthwash, the creative experiment of inventor draws, by mass percentage, raw material bag
Include：1.5%~3.5% green-tea extract, 0.5%~5% mint extract, 2.5%~3% emblic extract,
1.5%~5% licorice, during 0.5%~5% propolis extract, the effect of the oral health of its fresh breath etc.
It is best.
When oral care product is mouthspray, the creative experiment of inventor draws, by mass percentage, raw material bag
Include：0.5%~5% green-tea extract, 2.5%~5% mint extract, 1.2%~2% emblic extract,
0.5%~5% licorice, during 0.5%~5% propolis extract, its oral health for repairing oral mucosa etc.
Effect is best.
Feature of the invention and performance are described in further detail with reference to embodiments.
Embodiment 1-8
Embodiment 1-8 each provides a kind of bacteriostatic agent and preparation method thereof.
The part formulation of the bacteriostatic agent that embodiment 1-8 is provided is as shown in table 1 below：
Table 1
The preparation method of the bacteriostatic agent that embodiment 1-8 is provided is as follows：
Green tea, peppermint, emblic, Radix Glycyrrhizae and propolis are extracted respectively using water, ethanol by ultrasonic extraction technology,
Sound wave extraction design temperature is 15 DEG C, green-tea extract, the mint extract that will be obtained, emblic extract, licorice
Mix by above-mentioned weight portion with propolis extract, bacteriostatic agent is obtained.
Embodiment 9-16
Embodiment 9-16 each provides a kind of toothpaste and preparation method thereof.
The part formulation of the toothpaste that embodiment 9-16 is provided is as shown in table 2 below：
Table 2
The preparation method of the toothpaste that embodiment 9-16 is provided is as follows：
By load weighted green-tea extract, mint extract, emblic extract, licorice and propolis extract with
Appropriate grinding agent, NMF, adhesion agent, foaming agent, sweetener, essence and other compositions (preservative, pigment, water, work(
Effect additive etc.) conventionally it is made toothpaste.
Embodiment 17-24
Embodiment 17-24 each provides a kind of mouthwash and preparation method thereof.
The part formulation of the mouthwash that embodiment 17-24 is provided is as shown in table 3 below：
Table 3
The preparation method of the mouthwash that embodiment 17-24 is provided is as follows：
By load weighted green-tea extract, mint extract, emblic extract, licorice and propolis extract with
Appropriate NMF, emulsifying agent, sweetener, essence and other compositions (preservative, pigment, water, functional additive etc.) according to
Conventional method is made mouthwash.
Embodiment 25-32
Embodiment 25-32 each provides a kind of mouthspray and preparation method thereof.
The part formulation of the mouthspray that embodiment 25-32 is provided is as shown in table 4 below：
Table 4
The preparation method of the mouthspray that embodiment 25-32 is provided is as follows：
By load weighted green-tea extract, mint extract, emblic extract, licorice and propolis extract with
Appropriate NMF, emulsifying agent, flavor enhancement, ethanol, sweetener, essence and other compositions (preservative, pigment, water, effect
Additive etc.) conventionally it is made mouthspray.
Experimental example 1
(1) bacteriostatic agent kills effect to Escherichia coli
16 LB culture mediums are taken, the bacteriostatic agent that the embodiment 1-8 of equivalent prepares are taken and is put into wherein 8 culture mediums,
Experimental group 1-8 is provided accordingly to, remaining 8 culture mediums are set to control group 1-8 as a control group；Respectively to experimental group 1-
Escherichia coli are added in 8 and control group 1-8, total plate count situation in each culture medium is observed after 8 hours, be shown in Table 5.
(2) bacteriostatic agent kills effect to staphylococcus aureus
16 LB culture mediums are taken, the bacteriostatic agent that the embodiment 1-8 of equivalent prepares are taken and is put into wherein 3 culture mediums,
Experimental group 1-8 is provided accordingly to, remaining 8 culture mediums are set to control group 1-8 as a control group；Respectively to experimental group 1-
Staphylococcus aureus is added in 8 and control group 1-8, total plate count situation in each culture medium is observed after 8 hours, be shown in Table 5.
Table 5
From data in table 5, the bacteriostatic agent that embodiment 1-8 is prepared shows to Escherichia coli and staphylococcus
Significant killing effect, this shows, at least more than three kinds of plant extracts mutual cooperation energy provided in an embodiment of the present invention
Enough play a part of Synergistic and kill bacterium jointly.Wherein, wherein, to Escherichia coli and staphylococcic in embodiment 4-6
Insect killing effect is better than embodiment 1-3, and this shows, five Plant Extracts cooperate and can play optimal Synergistic biocidal
Effect, its sterilizing ability is better than only three kinds or Four Plants extract collective effect；To Escherichia coli and Portugal in embodiment 4-6
The insect killing effect of grape coccus is better than EXAMPLE Example 7-8, and this shows, in the data model that embodiment of the present invention creativeness is obtained
The bactericidal effect for enclosing the bacteriostatic agent of interior preparation is best.
Experimental example 2
Effect of the toothpaste provided in an embodiment of the present invention to improvement bleeding gums
From the similar subject of 90 dental healths, it is divided into 9 groups, every group of 10 people；Embodiment 9-16 is provided
Toothpaste (as experimental group 1-8), is carried out with the toothpaste (as a control group 1) without any functional component as together with reference substance
Clinical verification；Compare using 9 groups of average bleeding gums index BOP% of subject after same time, be shown in Table 6.
Table 6
| Sample | BOP baseline values (%) | After one month | After three months |
| Experimental group 1 | 4.02 | 2.86 | 1.72 |
| Experimental group 2 | 4.03 | 2.78 | 1.65 |
| Experimental group 3 | 4.02 | 2.72 | 1.58 |
| Experimental group 4 | 4.01 | 2.56 | 1.09 |
| Experimental group 5 | 4.05 | 2.61 | 1.10 |
| Experimental group 6 | 4.03 | 2.31 | 1.03 |
| Experimental group 7 | 4.05 | 2.88 | 1.36 |
| Experimental group 8 | 4.01 | 2.91 | 1.42 |
| Control group 1 | 4.02 | 3.36 | 2.65 |
From data in table 6, the BOP% values of the subject of experimental group 1-8 behind one month and three months have compared with
Be it is obvious decline, and be significantly better than that control group 1, this shows, due to the addition of at least more than three kinds of the present invention in toothpaste
The plant extracts that embodiment is provided can improve the improvement efficiency of bleeding gums.Wherein, the subject of experimental group 4-6 is at one
The moon and the BOP% after three months are worth down ratio to be more than experimental group 1-3, and this shows compared to addition three kinds and four kinds of present invention
The plant extracts that embodiment is improved, five Plant Extracts of addition are better able to comprehensively improve bleeding gums symptom；Experiment
BOP% of the subject of group 5 behind one month and three months is worth down ratio to be more than experimental group 4 and experimental group 6, and this shows,
When the effect of the improvement bleeding gums that the total addition level of five Plant Extracts is 6.5%~42% is best；Experimental group 4-6's receives
BOP% of the examination person behind one month and three months is worth down ratio to be more than experimental group 7-8, and this shows, implements according to the present invention
The ratio range of the creative plant extracts for obtaining of example is added in toothpaste, and the effect that it improves bleeding gums is best.
Experimental example 3
Mouthwash provided in an embodiment of the present invention offsets the effect of removing abnormal flavor in oral cavity
There is same degree implication patient from 90, be divided into 9 groups, every group of 10 people；By gargling that embodiment 17-24 is provided
Water (as experimental group 1-8), is carried out with the mouthwash (as a control group 1) without any functional component as together with reference substance
Experiment；Compare improves situation using 9 groups of implications of patient after same time, is shown in Table 7.
Table 7
| Sample | Suffer from implication degree | After two weeks | After one month |
| Experimental group 1 | Seriously | Be improved significantly | Without implication |
| Experimental group 2 | Seriously | Be improved significantly | Without implication |
| Experimental group 3 | Seriously | Be improved significantly | Without implication |
| Experimental group 4 | Seriously | Be improved significantly, almost without implication | Breath freshening |
| Experimental group 5 | Seriously | Be improved significantly, almost without implication | Breath freshening |
| Experimental group 6 | Seriously | Be improved significantly, almost without implication | Breath freshening |
| Experimental group 7 | Seriously | Be improved significantly | Without implication |
| Experimental group 8 | Seriously | Be improved significantly | Without implication |
| Control group 1 | Seriously | Slightly improved | Implication is lighter |
From data in table 6, the implication patient of experimental group 1-8 implication degree after two weeks has obtained significantly changing
Kind, implication disappears after one month, and control group 1 implication does not still disappear after one month, this shows, due to adding in mouthwash
Having added at least more than three kinds of plant extracts provided in an embodiment of the present invention can be obviously improved oral environment, eliminate peculiar smell.
Wherein, the patient of experimental group 4-6 after one month compared with experimental group 1-3 implication disappearance on the basis of, implication is apparent from, this table
The bright plant extracts improved compared to three kinds and four kinds embodiment of the present invention of addition, five Plant Extracts of addition improve oral cavity
Environment, eliminate peculiar smell effect it is more preferable；The implication patient of experimental group 4-6 implication after one month is compared with experimental group 7-8 in implication
On the basis of disappearance, implication is apparent from, and this shows, the proportioning of the plant extracts obtained according to embodiment of the present invention creativeness
Scope is added in mouthwash, its improve oral environment, eliminate peculiar smell effect it is more preferable.
Experimental example 4
Mouthspray provided in an embodiment of the present invention offsets the effect for repairing oral mucosa
From 90 patients that there is same degree mucous membrane of mouth to fester, it is divided into 9 groups, every group of 10 people；By embodiment 25-32
The mouthspray (as experimental group 1-8) of offer, with mouthspray (as a control group 1) conduct without any functional component
Reference substance is tested together；Compare and repair situation using 9 groups of mucous membrane of mouth of patient after same time, be shown in Table 8.
Table 8
From data in table 8, the oral lesions patient of experimental group 1-8 oral lesions degree after two weeks has obtained bright
Aobvious improvement even disappears, and control group 1 oral lesions degree still will more be planted after two weeks, this shows, in mouthspray
The part festered can have substantially been repaired due to the addition of at least more than three kinds of plant extracts provided in an embodiment of the present invention.
Wherein, the patient of experimental group 4-6 after two weeks oral lesions repair degree be better than experimental group 1-3, this show compared to addition three
Plant and four kinds of plant extracts of embodiment of the present invention raising, add the synergy of five Plant Extracts more, Neng Gouxian
Write and repair oral lesions；Oral lesions repair degree better than experimental group 7-8 to the oral lesions patient of experimental group 4-6 after two weeks,
This shows that the ratio range of the plant extracts obtained according to embodiment of the present invention creativeness is added in mouthspray, and it is repaiied
The effect of multiple oral lesions is more preferable.
In sum, the bacteriostatic agent as obtained in plant composition provided in an embodiment of the present invention has good antibacterial sterilizing
Ability；Oral care product is obtained as additive by plant composition provided in an embodiment of the present invention has excellent mitigation tooth
Oulorrhagia, oral mucosa, fresh breath are repaired, eliminate effect of peculiar smell etc., be both adapted to occurring being used when oral cavity goes wrong,
It also is adapted for preventing to use in daily life.
Embodiments described above is a part of embodiment of the invention, rather than whole embodiments.Reality of the invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of selected implementation of the invention
Example.Based on the embodiment in the present invention, what those of ordinary skill in the art were obtained under the premise of creative work is not made
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
1. a kind of plant additive, it is characterised in that including at least three kinds separable plant extracts each other, the plant carries
Take thing and be selected from green-tea extract, mint extract, emblic extract, licorice and propolis extract.
2. plant additive according to claim 1, it is characterised in that the green-tea extract, the mint extract,
The emblic extract, the licorice are identical with the formulation of the propolis extract.
3. a kind of bacteriostatic agent, it is characterised in that be made up of the plant additive described in claim 1.
4. bacteriostatic agent according to claim 3, it is characterised in that count by weight, including the green-tea extract
0.5-5.5 parts, described mint extract 6.5-8.5 parts, described emblic extract 0.5-1.5 parts, the licorice
1.5-2.5 parts and described propolis extract 0.5-5.5 parts.
5. application of a kind of plant additive as claimed in claim 1 in oral care product is prepared.
6. a kind of oral care product, it is characterised in that be made up of raw material, the raw material includes the plant described in claim 1
Additive, mass percent of the plant additive in the raw material is 5.2%~42%.
7. oral care product according to claim 6, it is characterised in that the plant additive is in the raw material
Mass percent is 6.5%~42%.
8. oral care product according to claim 6, it is characterised in that the oral care product is toothpaste, by matter
Amount percentages, the raw material includes：0.5%~5% green-tea extract, 2.5%~5% peppermint is extracted
Thing, 1.2%~2% emblic extract, 0.5%~5% licorice, 0.5%~5% honeybee
Glue extract.
9. oral care product according to claim 6, it is characterised in that the oral care product is mouthwash, is pressed
Mass percent meter, the raw material includes：1.5%~3.5% green-tea extract, 0.5%~5% peppermint carries
Take thing, 2.5%~3% emblic extract, 1.5%~5% licorice, 0.5%~5% it is described
Propolis extract.
10. oral care product according to claim 6, it is characterised in that the oral care product is mouthspray,
By mass percentage, the raw material includes：0.5%~5% green-tea extract, 2.5%~5% peppermint carries
Take thing, 1.2%~2% emblic extract, 0.5%~5% licorice, 0.5%~5% it is described
Propolis extract.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108498400A (en) * | 2018-05-23 | 2018-09-07 | 安徽广生堂生物科技有限公司 | The formula of one Plant Extracts mix preparation and its method for making cleaning agent for mouth cavity |
| CN110237241A (en) * | 2019-07-05 | 2019-09-17 | 广州康云生物科技有限公司 | A kind of compositions of additives containing lysozyme and plant extracts |
| CN112618451A (en) * | 2020-11-24 | 2021-04-09 | 云南云药医药研究有限公司 | Composition containing natural antibacterial ingredients and application |
| CN113197803A (en) * | 2021-04-29 | 2021-08-03 | 浙江吉叶生物科技有限公司 | Antibacterial mouth wash and preparation method thereof |
| CN113244155A (en) * | 2021-05-19 | 2021-08-13 | 广州冰泉化妆品科技有限公司 | Compound antibacterial mothproof mouthwash and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108498400A (en) * | 2018-05-23 | 2018-09-07 | 安徽广生堂生物科技有限公司 | The formula of one Plant Extracts mix preparation and its method for making cleaning agent for mouth cavity |
| CN110237241A (en) * | 2019-07-05 | 2019-09-17 | 广州康云生物科技有限公司 | A kind of compositions of additives containing lysozyme and plant extracts |
| CN112618451A (en) * | 2020-11-24 | 2021-04-09 | 云南云药医药研究有限公司 | Composition containing natural antibacterial ingredients and application |
| CN113197803A (en) * | 2021-04-29 | 2021-08-03 | 浙江吉叶生物科技有限公司 | Antibacterial mouth wash and preparation method thereof |
| CN113244155A (en) * | 2021-05-19 | 2021-08-13 | 广州冰泉化妆品科技有限公司 | Compound antibacterial mothproof mouthwash and preparation method thereof |
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| CN106924162B (en) | 2019-12-06 |
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Denomination of invention: A plant additive, antibacterial agent, oral care product, and the application of plant additives in the preparation of oral care products Effective date of registration: 20231225 Granted publication date: 20191206 Pledgee: Hua Xia Bank Co.,Ltd. Kunming Branch Pledgor: YUNNAN WEST GRASS RESOURCES DEVELOPMENT CO.,LTD. Registration number: Y2023980073832 |