CN107595750A - A kind of active inflammation-diminishing toothpaste - Google Patents
A kind of active inflammation-diminishing toothpaste Download PDFInfo
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- CN107595750A CN107595750A CN201710635935.0A CN201710635935A CN107595750A CN 107595750 A CN107595750 A CN 107595750A CN 201710635935 A CN201710635935 A CN 201710635935A CN 107595750 A CN107595750 A CN 107595750A
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Abstract
The invention discloses the invention provides a kind of active inflammation-diminishing toothpaste, Cordyceps militaris elite, propolis extract, Manuka honey, the alcohol of O cymenes 5, potassium nitrate, lemon tea oil and fragrant Chinese holly leaf oil are included.Contain a variety of natural extracts in active inflammation-diminishing toothpaste of the present invention, under the collective effect of the active component of a variety of natural extracts, so that there is active inflammation-diminishing toothpaste of the present invention significant antiphlogistic antibacterial to act on, various oral cavity pathogens can efficiently be resisted, the generation of the mouth diseases such as pre- preventing parodontitis, gingivitis, it is overall to improve oral environment, long-term use of oral problem such as toothpaste, canker sore, gingivitis, hemodia can be improved significantly.
Description
Technical field
The present invention relates to a kind of toothpaste, and in particular to a kind of active inflammation-diminishing toothpaste.
Background technology
Gingivitis, periodontitis, sensitivity of tooth and canker sore etc. are all current most commonly seen mouth diseases, oral health
Importance also recognized therewith by crowd.Gingivitis shows as bleeding gums, red and swollen, distending pain, continues development and invades sclerous tissues,
Periodontitis, including the inflammation of gingiva tissue and general disease are produced in the performance of gum.Bleeding gums majority is because on facing
The soft dirt of bacterial plaque (bacterium) do not remove in time, bacterial plaque calcification is formed dental calculus, corresponding portion by the calcium ion in saliva at leisure
The gum of position is stimulated by dental calculus for a long time, telangiectasis, permeability enhancing, CBF increase, causes gum to be changed into fresh
Red or kermesinus, gingival papilla swelling, stippling disappear, edge is thickening, and gum is no longer close to facing, cause gum it is soft it is fragile,
Gingival sulcus is deepened.When brushing teeth or feeding, due to mechanical irritation, the gum under this inflammatory conditions is just easy to bleeding.
Relatively effective sterilization component in present formulation of tooth-paste is mainly antibiotic, but long-term use of antibiosis is known as
Flora imbalance may be caused, produce the adverse consequences such as drug resistance, therefore people expect that one kind both has antiinflammatory and bacteriostatic functions, and nothing
The toothpaste of side effect.
The content of the invention
A kind of active inflammation-diminishing toothpaste is provided it is an object of the invention to overcome the shortcomings of the prior art part.
To achieve the above object, the technical scheme taken of the present invention is：A kind of active inflammation-diminishing toothpaste, include Cordyceps militaris essence
China, propolis extract, Manuka honey, O- cymene -5- alcohol, potassium nitrate, lemon tea oil and fragrant Chinese holly leaf oil.
Cordyceps militaris, be the edible mushroom of food and medicament dual-purpose, Cordyceps militaris extract of the present invention, can by commercially available,
It can be the refined extract of fruiting bodies of cordyceps militaris gained after water extract-alcohol precipitation.Fruiting bodies of cordyceps militaris is to pass through Cordyceps militaris spawn
It is inoculated on solid medium, after the regular hour cultivates, the stroma of crocus is differentiated to form from hyphostoma development
(fructification), and this new fresh sporophore is gathered into laggard sector-style again and dry grinded obtained by the processing of powder；Fructification powder passes through water extracting alcohol
After refined processing after heavy, cordycepin, adenosine, cordycepic acid, polysaccharide, SOD enzymes and other functional ingredient are efficiently concentrated, especially
It is cordycepin functional component.
Fruiting bodies of cordyceps militaris in the present invention, it is made up of materials such as moisture, ash content, protein, fat, wherein containing more
Kind volatile compound, it is in the majority with aromatic aldehydes material, there is certain antibacterial and anti-inflammatory effect, but aromatic volatile composition is equal
More than one hour can not be retained under 50 DEG C of extraction temperature.Therefore, the active ingredient in fruiting bodies of cordyceps militaris is difficult in essence
Remained in system heating purification process, therefore the present invention can allow fruiting bodies of cordyceps militaris certainly by the addition of fruiting bodies of cordyceps militaris
The volatile ingredient of body completely enters toothpaste system.
Cordycepin, is first nucleosides separated from fungi antibiotics, molecular structure 3 ,-desoxyadenossine,
There is broad-spectrum antiseptic, research is found, it can suppress the growth of the pathogens such as streptococcus, staphylococcus, and cordycepin
Also there is stronger antiviral activity, thus play in formulation of tooth-paste natural antibacterial, anti-inflammatory, it is antiviral the effect of.Due to worm
Careless element is the main antipathogenic composition in Cordyceps militaris elite, and Cordyceps militaris elite addition directly affects cordycepin in formulation of tooth-paste
Content.
The present invention uses fruiting bodies of cordyceps militaris collocation Cordyceps militaris extract, can make in system containing cordycepin, cordyceps sinensis
Outside the multiple efficacies compositions such as acid, polysaccharide, SOD enzymes, the also volatile ingredient containing fruiting bodies of cordyceps militaris itself, so as to allow shield gum
The effect of protecting tooth is played to optimal.
Propolis, it is a kind of wax-like resin of honeybee production, is the antibacterial material that honeybee is used to maintain whole colony, propolis
Complicated component, mainly contain beeswax, resin, fragrant volatile oil, flavone compound etc..Propolis extract of the present invention,
It is a kind of water-soluble bee glue extract as obtained by alcohols extraction, there is the original bioactivity of propolis, plays antibacterium, resists
The multiple efficacies such as microorganism, anti-inflammatory, anti-oxidant, the toothpaste of long-term use of propolis-containing, the infection in oral cavity and throat and pre- can be treated
Anti-caries.
Manuka honey in the present invention, it is a kind of medical grade honey for originating from New Zealand and Australia, there is antibacterium, resist
The multiple efficacies such as fungi, antiviral activity.Manuka honey, compared with common honey, wherein containing dense methyl second
Dialdehyde (MGO), in the Manuka honey grade classification system approved in the world, it can be divided with MGO contents, when MGO contents are got over
Height, the effect of antibiotic health care are then better.Toothpaste is added in the present invention using Manuka honey of the MGO values not less than 263mg/kg to match somebody with somebody
Fang Dangzhong, long-term use of toothpaste containing this honey, there is certain opsonic action to canker sore, throat and stomach.
O- cymene -5- alcohol, it is a kind of bactericide of wide spectrum, there is potent infiltration bactericidal action, to golden yellow grape
Also oral cavity pathogen all has good antibacterial effect for coccus, porphyromonas gingivalis, can penetrate into bacterial plaque inner sterilization,
Suitable for inflammatory patients such as gingivitis, periodontitis, optional commercially available prod, such as Nanjing Si Baike biochemistry Industrial Co., Ltd.
Isopropyl Methylphenol etc..
Potassium nitrate, desensitization activity in the monograph of the desensitizing dental product of food and medicine Surveillance Authority of the U.S. (FDA) into
Point, the release of potassium ion, the nerve endings of dentinal tubule can be prevented to be activated, can be with enough potassium concentrations
Avoid pressing Intradental nerve to be upset, the permeability of dentine is reduced, so as to slow down the situation of dentine hypersensitivity.
Lemon tea tree, Lemon scented tea tree, the east coast in original Australia, the exclusive plant in Australia, peach gold
Ma section, belong to one kind of tea oil.Heretofore described lemon tea oil, it is a kind of light yellow essence with pure and fresh citris aromas
Oil, so that obtained by the extracting process of steam distillation, its main functional component is geranial and neral, and its sterilizing ability compares conventional tea
Tree oil is stronger, is natural antiphlogistic, and smell is different from traditional bitter pungent tea oil, with more calmness, antiallergic, resists
The ability of infection.
Fragrant Chinese holly, Agonis fragrans, Australia western part is mainly grown in, belongs to Myrtaceae.Heretofore described fragrant Chinese holly leaf
Oil, it is the pure and sweet essential oil that a kind of micro-strip has Chinese cassia tree acrid odors, obtained by fragrant Chinese holly blade steam distillation.Fragrant Chinese holly leaf oil, its is special
Part in essential oil three kinds of main active components (cineole, firpene, alcohols) a perfect Golden Triangle ratio be present, because
For three kinds of active component perfect adaptations, fragrant Chinese holly leaf oil has the multiple efficacies such as antibacterial, anti-inflammatory, analgesia and resolving sputum.
Cordyceps militaris elite, propolis extract, Manuka honey, O- cymenes -5- in active inflammation-diminishing toothpaste of the present invention
The multiple active skull cap components such as alcohol, lemon tea oil and fragrant Chinese holly leaf oil, in addition to effects of antiinflammation and bacteriostasis, also there is calmness
With the effect of antiallergic, the generation of the mouth disease such as various oral cavity pathogens, pre- preventing parodontitis, gingivitis can be efficiently resisted, it is overall
Improve oral environment.Multiple active skull cap components are combined with antiallergic factor sylvite is applied to active anti-inflammatory of the present invention jointly
Toothpaste, energy compound synergic, there is significant antiphlogistic antibacterial and antiallergic to act on, long-term use of toothpaste, canker sore, gingivitis
The oral problems such as disease, hemodia can be improved significantly.
Preferably, the active inflammation-diminishing toothpaste includes the preparing raw material of following weight percentage：Cordyceps militaris elite 0.1~
5%th, propolis extract 0.05~1%, Manuka honey 0.05~1%, O- cymene -5- alcohol 0.01~0.1%, potassium nitrate 3
~10%, lemon tea oil 0.02~1% and fragrant Chinese holly leaf oil 0.02~1%.
To study and draw repeatedly through inventor, when the content of Cordyceps militaris elite is less than 0.1%, bacteriostasis is not notable, with
The increase of the content of Cordyceps militaris elite, bacteriostasis enhancing, but when the content of Cordyceps militaris elite is more than 5%, with pupa worm
The addition increase of careless elite, fungistatic effect increase is not notable, when the content of Cordyceps militaris elite is 0.1~5%, has preferable
Bactericidal action；When each component cooperates under the ratio, the antibacterial and anti-sensitization of anti-inflammatory significantly increases, and can effectively subtract
Light gum redness bleeding problems and sensitivity of tooth problem.
Preferably, the active inflammation-diminishing toothpaste includes the preparing raw material of following weight percentage：Cordyceps militaris elite 0.5~
3%th, propolis extract 0.2~0.8%, Manuka honey 0.1~1%, O- cymene -5- alcohol 0.05~0.08%, potassium nitrate 3
~5%, lemon tea oil 0.1~0.5% and fragrant Chinese holly leaf oil 0.1~0.5%.
Study and draw repeatedly through inventor, comprehensive anti-inflammatory fungistatic effect and antiallergic effect, when each group is divided into above-mentioned content
Reach optimal, gum redness bleeding problems, sensitivity of tooth problem can significantly improve.
Preferably, the weight ratio of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Cordyceps militaris
Entity=80~99.9：0.01~20.
When Cordyceps militaris extract and fruiting bodies of cordyceps militaris use above-mentioned weight ratio, both can give full play to respective effect,
System is set to contain cordycepin, cordycepic acid, polysaccharide, SOD enzymes and a variety of volatile compounds, so as to reach the work(of antiphlogistic and bactericidal
Effect.
It is highly preferred that the weight ratio of the Cordyceps militaris extract and fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Cordyceps militaris
Fructification=85~92：8~15.
When Cordyceps militaris extract and fruiting bodies of cordyceps militaris use above-mentioned weight ratio, the bactericidal effect that toothpaste reaches is optimal.
Preferably, the preparing raw material of the active inflammation-diminishing toothpaste also includes NMF, rubbing agent, thickener and foaming agent.
Preferably, in the preparing raw material of the active inflammation-diminishing toothpaste, the weight percentage of the NMF for 35~
60%, the weight percentage of the rubbing agent is 14~30%, and the weight percentage of the thickener is 0.5~3%, institute
The weight percentage for stating foaming agent is 1.8~3%.
Preferably, the foaming agent is at least one of amino acid surfactant and amphoteric surfactant and 12
The mixture of sodium alkyl sulfate.
It is highly preferred that the foaming agent is sodium lauroyl sarcosine, sodium lauroylmethyl taurate and cocamidopropyl propyl amide
At least one of glycine betaine and the mixture of lauryl sodium sulfate.
It is highly preferred that the foaming agent is sodium lauroyl sarcosine, sodium lauroylmethyl taurate and cocamidopropyl propyl amide
At least one of glycine betaine and the mixture of lauryl sodium sulfate.
When foaming agent of the present invention only uses lauryl sodium sulfate, foam is few and thin, and mouthfeel of brushing teeth is slightly poor, ammonia of arranging in pairs or groups
When at least one of base acid surfaces activating agent, amphoteric surfactant, lather quickness can be accelerated, foam is fine and smooth abundant, solution
Certainly dry and astringent still sensory issues.The foaming agent is selected from commercially available prod, for example, Shanghai Austria can be selected in sodium lauroyl sarcosine
The OLI-4901 of Shanghai profit difficult to understand, Cocoamidopropyl betaine can be selected in the OLI-4208 of profit, lauroyl N-methyltaurine sodium
Galaxy Surfactants CAPB DC, the Lenotain C30 that Shanghai profit is contained can be selected, wherein CAPB DC are specially for suitable.
Preferably, the rubbing agent be precipitated silica, superfine silicon dioxide, calcium monohydrogen phosphate and calcium carbonate at least
It is a kind of.
It is highly preferred that the rubbing agent be at least one of precipitated silica, calcium monohydrogen phosphate and calcium carbonate with it is ultra-fine
The mixture of silica, wherein, in the preparing raw material of the active inflammation-diminishing toothpaste, the weight percentage of superfine silicon dioxide
For 2~6%.
Weight percentage of the superfine silicon dioxide in the preparing raw material of the toothpaste is 2~6%.When ultra-fine two
When silica dosage is less than 2%, lotion surface is more rough, and mouthfeel of brushing teeth can be poor, when superfine silicon dioxide dosage is more than 6%
When, be easily hardened under lotion high temperature water outlet, influences stability.The liquid absorption of superfine silicon dioxide is 30~44ml/20g, preferably
30~38ml/20g superfine silicon dioxide, commercially available prod, such as comprehensive silica of snow company etc. can be used.It is heavy
The liquid absorption of shallow lake type silica is 15~25ml/20g, preferably 18~22ml/20g Precipitated silicon dioxide, can be used
Commercially available prod, such as Zeodent115 of HUBER companies etc..The liquid absorption of calcium bicarbonate is 5.0~6.5ml/20g, apparent close
Spend and tend to maximum, while apparent density trend minimum value for 0.80~1.00g/mL, preferably liquid absorption, commercially available production can be used
Product, such as toothpaste grade calcium hydrophosphate of De Bang companies etc..The liquid absorption of calcium carbonate is 3.8~5.0ml/20g, preferably 3.8~
4.2ml/20g calcium carbonate, commercially available prod, such as calcite in powder of Man Tingfang companies etc. can be used.
Preferably, the thickener is at least one of sodium carboxymethylcellulose, carbomer and xanthans；The moisturizing
Agent is at least one of D-sorbite, glycerine, polyethylene glycol and propane diols.
Commercially available prod can be selected in sodium carboxymethylcellulose, such as the TH10 (toothpaste level) of ASHLAND companies, its substitution value are
0.75~1.02, preferably 0.95~1.02,2% solution viscosity are 600~3000mPas, preferably 1200~
2500mPas cellulose.Commercially available prod, such as the CARBOPOL956 of Lubrizol companies can be selected in carbomer(toothpaste level), pH value is adjusted in 7 or so (in 6.5-7.5 interval ranges) with 25%NaOH solution,
Its viscosity, 0.6% neutralization solution viscosity are surveyed under 20rpm with Brookfield RV6 rotors：15000~40000mPa
S, preferably in 20000~30000mPas.Xanthans, also known as xanthan gum, optional commercially available prod, such as CPKelco companiesXanthan Gum (oral cavity level), its 1% xanthans is in 1%KCl solution, with Brookfield RV6
Rotor surveys its viscosity under 20rpm, and viscosity is 1200~1600mPas.
The active inflammation-diminishing toothpaste of the present invention, in addition to said components clearly require, in the model of lossless effect of the invention
In enclosing, other adjunct ingredients can be added or used to, auxiliary material can be sweetener, pH adjusting agent, spices, colouring agent and fluoride
Conventional content can be selected according to conventional criteria Deng, those skilled in the art.
Preferably, the active inflammation-diminishing toothpaste also includes the composition of following mass percent：Sweetener 0.1~2%, pH are adjusted
Save agent 0.1~3% and spices 0.1~2%.
Preferably, the sweetener is at least one of saccharin sodium, Sucralose and STEVIA REBAUDIANA；The spices is peppermint
At least one of brain, peppermint oil, spearmint oil, wintergreen, American mint, orange oil, lemon oil, fennel oil, eucalyptus oil；Institute
PH adjusting agent is stated as at least one in sodium hydroxide, ATSP, sodium tripolyphosphate, alkaline phosphate and sodium dihydrogen phosphate
Kind.
The preparation method of above-mentioned active inflammation-diminishing toothpaste, comprises the following steps：
(1), potassium nitrate and auxiliary material are pre-dissolved；
(2), rubbing agent, thickener are premixed；
(3), the material in NMF and step (1) is added in cream tank processed；
(4) vacuum system of cream tank processed, is opened, is vacuumized, mixture, Cordyceps militaris elite, propolis obtained by step (2) are carried
Take thing, Manuka honey, O- cymene -5- alcohol, potassium nitrate, lemon tea oil and fragrant Chinese holly leaf oil to add, keep vacuum -
Homogeneous is stirred between 0.05Mpa~-0.085Mpa；
(5) foaming agent, is added in cream tank processed, keeps vacuum to continue stirring between -0.05Mpa~-0.085Mpa equal
Matter；
(6), will cream tank processed to deaerate to vacuum be -0.092Mpa~-0.098Mpa, go out cream, produce the active anti-inflammatory
Toothpaste.
The beneficial effects of the present invention are：The invention provides a kind of active inflammation-diminishing toothpaste, active anti-inflammatory of the present invention
Contain a variety of natural extracts in toothpaste, under the collective effect of the active component of a variety of natural extracts so that institute of the present invention
Stating active inflammation-diminishing toothpaste, there is significant antiphlogistic antibacterial to act on, and can efficiently resist various oral cavity pathogens, pre- preventing parodontitis, gum
The generation of the mouth diseases such as inflammation, it is overall to improve oral environment, long-term use of toothpaste, canker sore, gingivitis, hemodia
Etc. oral problem can be improved significantly.
Brief description of the drawings
Fig. 1 is antibacterial test comparison figure of the embodiment 5 with 1~7 toothpaste of comparative example to staphylococcus aureus；
Fig. 2 is antibacterial test comparison figure of the embodiment 5 with 1~7 toothpaste of comparative example to streptococcus mutans；
Fig. 3 is antibacterial test comparison figure of the embodiment 5 with 1~7 toothpaste of comparative example to porphyromonas monococcus.
Embodiment
To better illustrate the object, technical solutions and advantages of the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Embodiment 1
A kind of embodiment of active inflammation-diminishing toothpaste of the present invention, include the preparing raw material of following weight percentage：Pupa
Lungfit 0.1%, propolis extract 0.05%, Manuka honey 0.05%, O- cymene -5- alcohol 0.01%, potassium nitrate
3%th, lemon tea oil 0.02%, fragrant Chinese holly leaf oil 0.02%, NMF 60%, rubbing agent 14%, thickener 0.5%, foaming agent
1.8%th, the deionized water of sweetener 0.1%, pH adjusting agent 0.1%, spices 0.1% and surplus；
Wherein, the Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, and the Cordyceps militaris carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=99.9：0.01；The NMF
For D-sorbite；The thickener is sodium carboxymethylcellulose；The foaming agent is sodium lauroyl sarcosine and dodecyl sulphur
The mixture of sour sodium；The mixture of the rubbing agent precipitated silica and superfine silicon dioxide, superfine silicon dioxide is described
Weight percentage in the preparing raw material of active inflammation-diminishing toothpaste is 2%；The sweetener is saccharin sodium；The spices is peppermint
Brain；The pH adjusting agent is alkaline phosphate and sodium dihydrogen phosphate.
Embodiment 2
A kind of embodiment of active inflammation-diminishing toothpaste of the present invention, include the preparing raw material of following weight percentage：Pupa
Lungfit 5%, propolis extract 1%, Manuka honey 1%, O- cymene -5- alcohol 0.05~0.1%, potassium nitrate 10%,
Lemon tea oil 1%, fragrant Chinese holly leaf oil 1%, NMF 35%, rubbing agent 20%, thickener 3%, foaming agent 3%, sweetener
2%th, the deionized water of pH adjusting agent 3%, spices 2% and surplus；
Wherein, the Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, and the Cordyceps militaris carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=80：20；The NMF is mountain
The mixture of pears sugar alcohol and glycerine；The thickener is the mixture of sodium carboxymethylcellulose and carbomer；The foaming agent is
The mixture of sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is calcium monohydrogen phosphate and superfine silicon dioxide
Mixture, weight percentage of the superfine silicon dioxide in the preparing raw material of the active inflammation-diminishing toothpaste be 6%；The sweet tea
Taste agent is Sucralose；The spices is spearmint oil；The pH adjusting agent is sodium hydroxide.
Embodiment 3
A kind of embodiment of active inflammation-diminishing toothpaste of the present invention, include the preparing raw material of following weight percentage：Pupa
Lungfit 0.5%, propolis extract 0.2%, Manuka honey 0.1%, O- cymene -5- alcohol 0.05%, potassium nitrate 3%,
Lemon tea oil 0.1%, fragrant Chinese holly leaf oil 0.1~1%, NMF 40%, rubbing agent 30%, thickener 0.5%, foaming agent
1.8%th, sweetener 0.1%, pH adjusting agent 0.1%, spices 0.1%, the deionized water of surplus；
Wherein, the Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, and the Cordyceps militaris carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=92：8；The NMF is sorb
The mixture of sugar alcohol and propane diols；The thickener is the mixture in sodium carboxymethylcellulose and xanthans；The foaming agent
For Cocoamidopropyl betaine and the mixture of lauryl sodium sulfate；The rubbing agent is calcium carbonate and superfine silicon dioxide
Mixture, weight percentage of the superfine silicon dioxide in the preparing raw material of the active inflammation-diminishing toothpaste be 4%；The sweet tea
Taste agent is STEVIA REBAUDIANA；The spices is lemon oil；The pH adjusting agent is ATSP.
Embodiment 4
A kind of embodiment of active inflammation-diminishing toothpaste of the present invention, include the preparing raw material of following weight percentage：Pupa
Lungfit 3%, propolis extract 0.8%, Manuka honey 0.5%, O- cymene -5- alcohol 0.08%, potassium nitrate 5%, lemon
Lemon tea oil 0.5%, fragrant Chinese holly leaf oil 0.5%, NMF 45%, rubbing agent 20%, thickener 2%, foaming agent 2%, sweetener
1%th, the deionized water of pH adjusting agent 2%, spices 1% and surplus；
Wherein, the Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, and the Cordyceps militaris carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=85：15；NMF is sorbose
The mixture of alcohol and glycerine；The thickener is carbomer；The foaming agent is sodium lauroyl sarcosine, lauroyl methyl ox sulphur
The mixture of sour sodium and lauryl sodium sulfate；The rubbing agent is the mixture of precipitated silica and superfine silicon dioxide,
Weight percentage of the superfine silicon dioxide in the preparing raw material of the active inflammation-diminishing toothpaste is 6%；The sweetener is sugar
Smart sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Embodiment 5
A kind of embodiment of active inflammation-diminishing toothpaste of the present invention, include the preparing raw material of following weight percentage：Pupa
Lungfit 2.5%, propolis extract 0.5%, Manuka honey 0.5%, O- cymene -5- alcohol 0.08%, potassium nitrate 5%,
Lemon tea oil 0.5%, fragrant Chinese holly leaf oil 0.5%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweet taste
Agent 1%, pH adjusting agent 2%, the deionized water of spices 1% and surplus；
Wherein, the Cordyceps militaris elite is the mixture of Cordyceps militaris extract and fruiting bodies of cordyceps militaris, and the Cordyceps militaris carries
The weight of the thing and fruiting bodies of cordyceps militaris ratio is taken to be：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=90：10；NMF is sorbose
The mixture of alcohol and glycerine；The thickener is carbomer；The foaming agent is sodium lauroyl sarcosine, lauroyl methyl ox sulphur
The mixture of sour sodium and lauryl sodium sulfate；The rubbing agent is the mixture of precipitated silica and superfine silicon dioxide,
Weight percentage of the superfine silicon dioxide in the preparing raw material of the active inflammation-diminishing toothpaste is 4%；The sweetener is sugar
Smart sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Embodiment 6
A kind of embodiment of active inflammation-diminishing toothpaste of the present invention, the present embodiment activity inflammation-diminishing toothpaste and the activity of embodiment 5
The difference of the content that the difference is that only Cordyceps militaris elite of inflammation-diminishing toothpaste, the pupa worm of active inflammation-diminishing toothpaste described in the present embodiment
Weight percentage of the careless elite in the preparing raw material of toothpaste is 5%.
Embodiment 7
A kind of embodiment of active inflammation-diminishing toothpaste of the present invention, the present embodiment activity inflammation-diminishing toothpaste and the activity of embodiment 5
The difference of the content that the difference is that only Cordyceps militaris elite of inflammation-diminishing toothpaste, the pupa worm of active inflammation-diminishing toothpaste described in the present embodiment
Weight percentage of the careless elite in the preparing raw material of toothpaste is 4%.
Embodiment 8
A kind of embodiment of active inflammation-diminishing toothpaste of the present invention, the present embodiment activity inflammation-diminishing toothpaste and the activity of embodiment 5
The difference of the content that the difference is that only Cordyceps militaris elite of inflammation-diminishing toothpaste, the pupa worm of active inflammation-diminishing toothpaste described in the present embodiment
Weight percentage of the careless elite in the preparing raw material of toothpaste is 2%.
Embodiment 9
A kind of embodiment of active inflammation-diminishing toothpaste of the present invention, the present embodiment activity inflammation-diminishing toothpaste and the activity of embodiment 5
The difference of the content that the difference is that only Cordyceps militaris elite of inflammation-diminishing toothpaste, the pupa worm of active inflammation-diminishing toothpaste described in the present embodiment
Weight percentage of the careless elite in the preparing raw material of toothpaste is 1%.
Embodiment 10
A kind of embodiment of active inflammation-diminishing toothpaste of the present invention, the present embodiment activity inflammation-diminishing toothpaste and the activity of embodiment 5
The difference of the content that the difference is that only Cordyceps militaris elite of inflammation-diminishing toothpaste, the pupa worm of active inflammation-diminishing toothpaste described in the present embodiment
Weight percentage of the careless elite in the preparing raw material of toothpaste is 0.1%.
Embodiment 11
A kind of embodiment of active inflammation-diminishing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in the present embodiment
5 weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in the present embodiment
The weight of extract and fruiting bodies of cordyceps militaris ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=99.9：0.01.
Embodiment 12
A kind of embodiment of active inflammation-diminishing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in the present embodiment
5 weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in the present embodiment
The weight of extract and fruiting bodies of cordyceps militaris ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=95：5.
Embodiment 13
A kind of embodiment of active inflammation-diminishing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in the present embodiment
5 weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in the present embodiment
The weight of extract and fruiting bodies of cordyceps militaris ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=92：8.
Embodiment 14
A kind of embodiment of active inflammation-diminishing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in the present embodiment
5 weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in the present embodiment
The weight of extract and fruiting bodies of cordyceps militaris ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=85：15.
Embodiment 15
A kind of embodiment of active inflammation-diminishing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in the present embodiment
5 weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in the present embodiment
The weight of extract and fruiting bodies of cordyceps militaris ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=80：20.
Comparative example 1
A kind of comparative example of active inflammation-diminishing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in this comparative example
5 difference is, without Cordyceps militaris elite, propolis extract, Mai Luka honeybees in the preparing raw material of toothpaste described in this comparative example
Honey, O- cymene -5- alcohol, lemon tea oil and fragrant Chinese holly leaf oil, i.e. toothpaste described in this comparative example include following weight percentage
Preparing raw material：Potassium nitrate 5%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%, pH are adjusted
Save the deionized water of agent 2%, spices 1% and surplus；
Wherein, NMF is the mixture of D-sorbite and glycerine；The thickener is carbomer；The foaming agent is the moon
The mixture of osmanthus acylsarcosine sodium, sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is precipitation dioxy
The mixture of SiClx and superfine silicon dioxide, weight hundred of the superfine silicon dioxide in the preparing raw material of the active inflammation-diminishing toothpaste
It is 4% to divide content；The sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Comparative example 2
A kind of comparative example of active inflammation-diminishing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in this comparative example
5 difference is, in the preparing raw material of toothpaste described in this comparative example without propolis extract, Manuka honey, O- cymenes-
5- alcohol, lemon tea oil and fragrant Chinese holly leaf oil, i.e. toothpaste described in this comparative example include the preparing raw material of following weight percentage：Pupa
Lungfit 2.5%, potassium nitrate 5%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%,
The deionized water of pH adjusting agent 2%, spices 1% and surplus；
Wherein, NMF is the mixture of D-sorbite and glycerine；The thickener is carbomer；The foaming agent is the moon
The mixture of osmanthus acylsarcosine sodium, sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is precipitation dioxy
The mixture of SiClx and superfine silicon dioxide, weight hundred of the superfine silicon dioxide in the preparing raw material of the active inflammation-diminishing toothpaste
It is 4% to divide content；The sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Comparative example 3
A kind of comparative example of active inflammation-diminishing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in this comparative example
5 difference is, in the preparing raw material of toothpaste described in this comparative example without Cordyceps militaris elite, Manuka honey, O- cymenes-
5- alcohol, lemon tea oil and fragrant Chinese holly leaf oil, i.e. toothpaste described in this comparative example include the preparing raw material of following weight percentage：Honeybee
Glue extract 0.5%, potassium nitrate 5%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%,
The deionized water of pH adjusting agent 2%, spices 1% and surplus；
Wherein, NMF is the mixture of D-sorbite and glycerine；The thickener is carbomer；The foaming agent is the moon
The mixture of osmanthus acylsarcosine sodium, sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is precipitation dioxy
The mixture of SiClx and superfine silicon dioxide, weight hundred of the superfine silicon dioxide in the preparing raw material of the active inflammation-diminishing toothpaste
It is 4% to divide content；The sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Comparative example 4
A kind of comparative example of active inflammation-diminishing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in this comparative example
5 difference is, without Cordyceps militaris elite, propolis extract, Mai Luka honeybees in the preparing raw material of toothpaste described in this comparative example
Honey, lemon tea oil and fragrant Chinese holly leaf oil, i.e. toothpaste described in this comparative example include the preparing raw material of following weight percentage：O- umbrellas
Flower hydrocarbon -5- alcohol 0.08%, potassium nitrate 5%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener
1%th, the deionized water of pH adjusting agent 2%, spices 1% and surplus；
Wherein, NMF is the mixture of D-sorbite and glycerine；The thickener is carbomer；The foaming agent is the moon
The mixture of osmanthus acylsarcosine sodium, sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is precipitation dioxy
The mixture of SiClx and superfine silicon dioxide, weight hundred of the superfine silicon dioxide in the preparing raw material of the active inflammation-diminishing toothpaste
It is 4% to divide content；The sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Comparative example 5
A kind of comparative example of active inflammation-diminishing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in this comparative example
5 difference is, without Cordyceps militaris elite, propolis extract, Mai Luka honeybees in the preparing raw material of toothpaste described in this comparative example
Honey, O- cymene -5- alcohol and fragrant Chinese holly leaf oil, i.e. toothpaste described in this comparative example include the preparing raw material of following weight percentage：
Lemon tea oil 0.5%, potassium nitrate 5%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener
1%th, the deionized water of pH adjusting agent 2%, spices 1% and surplus；
Wherein, NMF is the mixture of D-sorbite and glycerine；The thickener is carbomer；The foaming agent is the moon
The mixture of osmanthus acylsarcosine sodium, sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is precipitation dioxy
The mixture of SiClx and superfine silicon dioxide, weight hundred of the superfine silicon dioxide in the preparing raw material of the active inflammation-diminishing toothpaste
It is 4% to divide content；The sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Comparative example 6
A kind of comparative example of active inflammation-diminishing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in this comparative example
5 difference is, in the preparing raw material of toothpaste described in this comparative example without Cordyceps militaris elite, propolis extract, O- cymenes-
5- alcohol, lemon tea oil and fragrant Chinese holly leaf oil, i.e. toothpaste described in this comparative example include the preparing raw material of following weight percentage：Wheat
Lu's card honey 0.5%, potassium nitrate 5%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener 1%,
The deionized water of pH adjusting agent 2%, spices 1% and surplus；
Wherein, NMF is the mixture of D-sorbite and glycerine；The thickener is carbomer；The foaming agent is the moon
The mixture of osmanthus acylsarcosine sodium, sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is precipitation dioxy
The mixture of SiClx and superfine silicon dioxide, weight hundred of the superfine silicon dioxide in the preparing raw material of the active inflammation-diminishing toothpaste
It is 4% to divide content；The sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Comparative example 7
A kind of comparative example of active inflammation-diminishing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in this comparative example
5 difference is, without Cordyceps militaris elite, propolis extract, Mai Luka honeybees in the preparing raw material of toothpaste described in this comparative example
The preparation that honey, O- cymene -5- alcohol and lemon tea oil, i.e. toothpaste described in this comparative example include following weight percentage is former
Material：Fragrant Chinese holly leaf oil 0.5%, potassium nitrate 5%, NMF 50%, rubbing agent 22%, thickener 2%, foaming agent 2%, sweetener
1%th, the deionized water of pH adjusting agent 2%, spices 1% and surplus；
Wherein, NMF is the mixture of D-sorbite and glycerine；The thickener is carbomer；The foaming agent is the moon
The mixture of osmanthus acylsarcosine sodium, sodium lauroylmethyl taurate and lauryl sodium sulfate；The rubbing agent is precipitation dioxy
The mixture of SiClx and superfine silicon dioxide, weight hundred of the superfine silicon dioxide in the preparing raw material of the active inflammation-diminishing toothpaste
It is 4% to divide content；The sweetener is saccharin sodium；The spices is orange oil；The pH adjusting agent is ATSP.
Comparative example 8
A kind of comparative example of active inflammation-diminishing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in this comparative example
The difference of 5 content that the difference is that only Cordyceps militaris elite, the Cordyceps militaris elite of active inflammation-diminishing toothpaste described in this comparative example
Weight percentage in the preparing raw material of toothpaste is 6%.
Comparative example 9
A kind of comparative example of shield gum healing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in this comparative example
5 weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in this comparative example
The weight of extract and fruiting bodies of cordyceps militaris ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=100:0.
Comparative example 10
A kind of comparative example of shield gum healing toothpaste of the present invention, the preparing raw material and embodiment of toothpaste described in this comparative example
5 weight that the difference is that only Cordyceps militaris extract and fruiting bodies of cordyceps militaris than difference, Cordyceps militaris described in this comparative example
The weight of extract and fruiting bodies of cordyceps militaris ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=75:25.
Embodiment 16
Active inflammation-diminishing toothpaste described to embodiment 1~15 and 1~10 toothpaste of comparative example are for common several in oral cavity
Bacterium carries out antibacterial test.
Antibacterial method of testing：According to《Disinfection technology standard》2.1.8. anti-(suppression) equal test method, passes through third party's machine
Structure is tested.
The preparation of bacteria inhibition tablet：In the sterilized petri dishes of cleaning, a diameter of 5mm is made, thickness is no more than the suppression of 4mm disks (block)
Microbial inoculum original cream piece, one group of every 4 (blocks).
The preparation of negative control piece：Take sterile dry filter paper piece, every be added dropwise it is standby after sterile distilled water.
The inoculation of test organisms：Concentration is dipped as 5 × 10 with sterile cotton swab5Cfu/ml~5 × 106Cfu/ml test organisms hangs
Liquid, nutrient agar planar surface uniformly smear 3 times, often smear 1 time, flat board should rotate 60 °, finally by cotton swab around
Plate edge is smeared one week, is covered plate, is put drying at room temperature 5min.
Bacteriostatic agent print is placed with：Experiment is placed with 1 microbiological contamination flat board every time, and each flat board is placed with the examination of 4 same test groups
Test print, 1 negative control piece, totally 5.It is placed with aseptic nipper coupongs in planar surface.Between each print center apart
More than 25mm, the periphery with flat board is at a distance of more than 15mm.After being placed with, with the light pressure-like piece of aseptic nipper, it is set to be close to flat board
Surface.Plate is covered, puts 37 DEG C of incubators, culture 16h~18h observation results.With the direct of vernier caliper measurement antibacterial ring size and remember
Record, experiment are repeated 3 times.
The bacterial strain of this test has selected common oral cavity pathogen：Staphylococcus aureus, streptococcus mutans and gum
Porphyrin monococcus.
Antibacterial test evaluation standard：Inhibition zone diameter is more than 7mm person, has been judged to bacteriostasis；Inhibition zone diameter be less than or
Equal to 7mm person, no bacteriostasis is judged to.The antibacterial test result of 1~8 toothpaste of embodiment 1~10 and comparative example is shown in Table 1,
The antibacterial test comparison of embodiment 5 and 1~7 toothpaste of comparative example is shown in accompanying drawing 1~3, embodiment 5,11~15 and comparative example 9,
The antibacterial test result of 10 toothpaste is shown in Table 2.
The antibacterial test result of 1~8 toothpaste of the embodiment 1~10 of table 1 and comparative example
As it can be seen from table 1 the fungistatic effect of the active inflammation-diminishing toothpaste of embodiment 1~10 is better than described in comparative example 1~8
The fungistatic effect of toothpaste, the fungistatic effect contrast of embodiment 5 and comparative example 1~7 can be drawn especially from accompanying drawing 1~3, be implemented
The fungistatic effect of example 5 be more than only add a Cordyceps militaris elite, propolis extract, Manuka honey, O- cymene -5- alcohol, potassium nitrate,
Lemon tea oil and fragrant Chinese holly leaf oil one or more therein, illustrate Cordyceps militaris elite, propolis extract, Manuka honey, O-
Cymene -5- alcohol, potassium nitrate, lemon tea oil and fragrant Chinese holly leaf oil compound in certain proportion can play Synergistic
Effect.It can draw from the fungistatic effect comparative example of embodiment 5~10 and comparative example 8, with the addition of Cordyceps militaris elite
Increase, fungistatic effect increase, but comparative example 8 is compared with Example 6, addition adds 1%, but fungistatic effect increase is not
Substantially.
The embodiment 5,11~15 of table 2 and comparative example 9, the antibacterial test result of 10 toothpaste
From table 2 it can be seen that in the case where Cordyceps militaris elite content is certain, with the increasing of fruiting bodies of cordyceps militaris content
Greatly, the fungistatic effect of made toothpaste is in the trend for first increasing and reducing afterwards, and real in Cordyceps militaris extract and Cordyceps militaris
The weight ratio of body is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=85~92：Effect reaches optimal when 8~15.
Embodiment 16
Clinical test, specific testing program are carried out to active inflammation-diminishing toothpaste of the present invention and 1~7 toothpaste of comparative example
It is as follows：
First, testing program
Double-blind randomized clinical trial designs, aspirations of the collection 200 with different degrees of gum redness bleeding problems by
Examination person, trial volunteer's age distribution is randomly divided into test group, control group I~VII at 18~60 years old, by subject, wherein testing
29 people of group, the people of control group I 23, the people of control group II 25, the people of control group III 24, the people of control group IV 25, the people of control group V 24, control group
VI 26, the people of control group VII 25, test group and control group I, II, III, IV, V, VI, VII are respectively using using activity of the present invention
1~7 toothpaste of inflammation-diminishing toothpaste and comparative example, check that trial volunteer is using tooth using the method for Oral epidemiological investigation
The index of correlation of tooth and gum during cream 4 weeks and 8 weeks.
2nd, application method
Toothbrush：Soft wire type toothbrush；
Dosage：Test group, the subject of control group I~V are brushed teeth 2 times sooner or later daily, use 2 grams of toothpaste every time.
3rd, observation item and index
1st, gingival index (GI)
Check gingival margin near, it is remote in, cheek side, the situation in 4 regions of tongue side, be divided into 0~3 grade of standard, 0 point of (gum
Normally)；1 point (not bleeding is examined in gum mild inflammation, color mild change, Mild edema, spy)；2 points of (gum moderate inflammation, colors
Bleeding is examined in red, oedema, light, spy)；3 points (gingivitis is obvious, red and swollen, there is ulcer, automatic hemorrhagic tendency).
2nd, gingival sulcus bleeding index (SBI)
Check gingival margin near, it is remote in, cheek side, the situation in 4 regions of tongue side, be divided into 4 grades, 1 point (not bleeding)；2 points
(bleeding during light spy gingival sulcus, gum outward appearance are normal)；3 points (bleeding when visiting gingival sulcus, gum redden, no swelling)；4 points (gum has ulcer
Or other symptoms).
3rd, plaque index (PLI)
It is divided into 4 grades according to bacterial plaque amount, 0 point (Yin Yuan areas are without bacterial plaque)；1 point (visual examination without bacterial plaque, but can be in free gum with probe
And proximity scrapes thin layer bacterial plaque)；2 points (in gingival pocket, dissociate gum area or the soft deposit adjacent to the visible moderate bulk amount of facing
Thing)；3 points (in gingival pocket or free gum area and neighbouring facing have a large amount of soft deposit things).
4th, test result
GI, SBI, PLI value take the average value of trial volunteer's situation in every group, and result of the test is shown in Table 3~5.
The test group of table 3 and the GI values of control group compare
The test group of table 4 and the SBI values of control group compare
| Test group | Before experiment | After 4 weeks | After 8 weeks |
| Test group | 3.45±0.49 | 2.06±0.39 | 1.21±0.50 |
| Control group I | 3.40±0.61 | 3.30±0.51 | 3.13±0.42 |
| Control group II | 3.69±0.40 | 3.01±0.42 | 2.64±0.36 |
| Control group III | 3.23±0.65 | 2.60±0.55 | 2.36±0.45 |
| Control group IV | 3.69±0.50 | 2.93±0.58 | 2.62±0.46 |
| Control group V | 3.21±0.51 | 2.50±0.61 | 2.29±0.40 |
| Control group VI | 3.33±0.50 | 2.69±0.43 | 2.25±0.44 |
| Control group VII | 3.12±0.66 | 2.41±0.39 | 2.22±0.40 |
The test group of table 5 and the PLI values of control group compare
From table 3~5 as can be seen that with comparative example 1~7 add Cordyceps militaris elite, propolis extract, Manuka honey,
O- cymene -5- alcohol, potassium nitrate, lemon tea oil are compared with fragrant Chinese holly leaf oil one or more of toothpaste therein, use this hair
The bright active inflammation-diminishing toothpaste can effectively treat gingivitis, more effectively treat bleeding gums, anti-inflammatory analgetic, and test group and
Control group is compared, and has significant difference (P ＜ 0.05).
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than the present invention is protected
The limitation of scope is protected, although being explained in detail with reference to preferred embodiment to the present invention, one of ordinary skill in the art should
Understand, technical scheme can be modified or equivalent substitution, without departing from the essence of technical solution of the present invention
And scope.
Claims (10)
1. a kind of active inflammation-diminishing toothpaste, it is characterised in that include Cordyceps militaris elite, propolis extract, Manuka honey, O- umbrellas flower
Hydrocarbon -5- alcohol, potassium nitrate, lemon tea oil and fragrant Chinese holly leaf oil；The Cordyceps militaris elite is that Cordyceps militaris extract and Cordyceps militaris are real
The mixture of body.
2. active inflammation-diminishing toothpaste as claimed in claim 1, it is characterised in that the active inflammation-diminishing toothpaste includes following weight percent
The preparing raw material of content：Cordyceps militaris elite 0.1~5%, propolis extract 0.05~1%, Manuka honey 0.05~1%, O-
Cymene -5- alcohol 0.01~0.1%, potassium nitrate 3~10%, lemon tea oil 0.02~1% and fragrant Chinese holly leaf oil 0.02~1%.
3. active inflammation-diminishing toothpaste as claimed in claim 1, it is characterised in that the active inflammation-diminishing toothpaste includes following weight percent
The preparing raw material of content：Cordyceps militaris elite 0.5~3%, propolis extract 0.2~0.8%, Manuka honey 0.1~1%, O-
Cymene -5- alcohol 0.05~0.08%, potassium nitrate 3~5%, lemon tea oil 0.1~0.5% and fragrant Chinese holly leaf oil 0.1~
0.5%.
4. active inflammation-diminishing toothpaste as claimed in claim 1, it is characterised in that the Cordyceps militaris extract and fruiting bodies of cordyceps militaris
Weight ratio is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=80~99.9：0.01~20；Preferably, the Cordyceps militaris extract
Weight ratio with fruiting bodies of cordyceps militaris is：Cordyceps militaris extract：Fruiting bodies of cordyceps militaris=85~92：8~15.
5. active inflammation-diminishing toothpaste as claimed in claim 1, it is characterised in that the preparing raw material of the active inflammation-diminishing toothpaste also includes
NMF, rubbing agent, thickener and foaming agent.
6. active inflammation-diminishing toothpaste as claimed in claim 5, it is characterised in that in the preparing raw material of the active inflammation-diminishing toothpaste, institute
The weight percentage for stating NMF is 35~60%, and the weight percentage of the rubbing agent is 14~30%, the thickening
The weight percentage of agent is 0.5~3%, and the weight percentage of the foaming agent is 1.8~3%.
7. active inflammation-diminishing toothpaste as claimed in claim 5, it is characterised in that the foaming agent is amino acid surfactant and two
Mixture of at least one of the property surfactant with lauryl sodium sulfate.
8. active inflammation-diminishing toothpaste as claimed in claim 5, it is characterised in that the foaming agent is sodium lauroyl sarcosine, bay
At least one of acyl methyl taurine sodium and Cocoamidopropyl betaine and the mixture of lauryl sodium sulfate.
9. active inflammation-diminishing toothpaste as claimed in claim 5, it is characterised in that the rubbing agent is precipitated silica, ultra-fine two
At least one of silica, calcium monohydrogen phosphate and calcium carbonate；Preferably, the rubbing agent is precipitated silica, calcium monohydrogen phosphate
With the mixture of at least one of calcium carbonate with superfine silicon dioxide, wherein, in the preparing raw material of the active inflammation-diminishing toothpaste,
The weight percentage of superfine silicon dioxide is 2~6%.
10. active inflammation-diminishing toothpaste as claimed in claim 4, it is characterised in that the thickener is sodium carboxymethylcellulose, card ripple
At least one of nurse and xanthans；The NMF is at least one in D-sorbite, glycerine, polyethylene glycol and propane diols
Kind.
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| CN110772475A (en) * | 2019-12-10 | 2020-02-11 | 广州瑞誉化工科技有限公司 | Probiotic toothpaste |
| CN111617021A (en) * | 2020-07-07 | 2020-09-04 | 上海格芒商贸有限责任公司 | Toothpaste for resisting oral helicobacter pylori |
| CN113069405A (en) * | 2021-04-27 | 2021-07-06 | 广州优妥生物科技有限公司 | Antibacterial toothpaste for relieving oral ulcer and preparation method thereof |
| CN115025022A (en) * | 2022-07-13 | 2022-09-09 | 博雅(广州)生物科技研究院有限公司 | Efficient antibacterial toothpaste and preparation method thereof |
| CN115025022B (en) * | 2022-07-13 | 2023-09-05 | 湖南互美电子商务有限公司 | Antibacterial toothpaste and preparation method thereof |
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