CN107595750B - Active anti-inflammation toothpaste - Google Patents
Active anti-inflammation toothpaste Download PDFInfo
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- CN107595750B CN107595750B CN201710635935.0A CN201710635935A CN107595750B CN 107595750 B CN107595750 B CN 107595750B CN 201710635935 A CN201710635935 A CN 201710635935A CN 107595750 B CN107595750 B CN 107595750B
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Abstract
The invention discloses an active anti-inflammatory toothpaste, which comprises cordyceps militaris essence, propolis extract, manuka honey, O-cymene-5-ol, potassium nitrate, lemon tea tree oil and aromatic holly leaf oil. The active anti-inflammatory toothpaste contains multiple natural extracts, and under the combined action of the active ingredients of the multiple natural extracts, the active anti-inflammatory toothpaste has remarkable anti-inflammatory and antibacterial effects, can efficiently resist various oral pathogenic bacteria, prevent oral diseases such as periodontitis and gingivitis, integrally improve the oral environment, and obviously improve oral problems such as oral ulcer, gingival inflammation and tooth allergy after long-term use.
Description
Technical Field
The invention relates to toothpaste, in particular to active anti-inflammation toothpaste.
Background
Gingivitis, periodontitis, tooth sensitivity, oral ulcer and the like are the most common oral diseases at present, and the importance of oral health care is also recognized by people. Gingivitis is characterized by bleeding, redness and swelling of the gums, swelling and pain, which continues to invade the hard tissues and produce periodontitis, including inflammation of the gum tissues and manifestations of systemic diseases in the gums. Most of the bleeding of gum is because the soft scale of the bacterial plaque (bacteria) on the tooth surface is not removed in time, calcium ions in saliva calcify the bacterial plaque to slowly form tartar, the gum of the corresponding part is stimulated by the tartar for a long time, the capillary vessel expands, the permeability is enhanced, the blood flow is increased, so that the gum becomes bright red or dark red, the gum nipple swells, the point color disappears, the edge becomes thick, the gum is not attached to the tooth surface any more, the gum is soft and fragile, and the gingival sulcus deepens. When brushing teeth or eating food, the gum in such an inflammatory state is easily bleedings due to mechanical stimulation.
The relatively effective bactericidal component in the existing toothpaste formula is mainly antibiotic, but the long-term use of the antibiotic can cause dysbacteriosis and generate drug resistance and other adverse effects, so people expect the toothpaste which has the functions of resisting inflammation and inhibiting bacteria and has no side effect.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide the active anti-inflammation toothpaste.
In order to achieve the purpose, the invention adopts the technical scheme that: an active anti-inflammatory toothpaste comprises Cordyceps militaris essence, propolis extract, manuka honey, O-cymene-5-ol, potassium nitrate, lemon tea tree oil and aromatic folium Ilicis Cornutae oil.
The cordyceps militaris is edible fungus for both food and medicine, and the cordyceps militaris extract can be purchased in the market and can also be a refined extract obtained by carrying out water extraction and alcohol precipitation on cordyceps militaris fruiting bodies. The Cordyceps militaris fruiting body is obtained by inoculating Cordyceps militaris strain on solid culture medium, culturing for a certain period of time, developing and differentiating mycelium to form orange rod-shaped stroma (fruiting body), collecting fresh fruiting body, air drying, and grinding; the fruiting body powder is refined after water extraction and alcohol precipitation, and effective components such as cordycepin, adenosine, cordycepic acid, polysaccharide, SOD enzyme and the like are efficiently concentrated, especially the effective components of cordycepin.
The cordyceps militaris sporocarp provided by the invention is composed of substances such as water, ash, protein and fat, contains various volatile compounds, contains more aromatic aldehyde substances, and has certain antibacterial and anti-inflammatory effects, but the aromatic volatile components cannot be retained for more than one hour at the extraction temperature of 50 ℃. Therefore, the effective components in the cordyceps militaris sporocarp are difficult to keep in the refining, heating and purifying processes, so that the volatile components of the cordyceps militaris sporocarp can completely enter a toothpaste system by adding the cordyceps militaris sporocarp.
Cordycepin, the first nucleoside antibiotic separated from fungi, has a molecular structure of 3-deoxyadenosine, has a broad-spectrum antibacterial effect, and is found to be capable of inhibiting the growth of pathogenic bacteria such as streptococcus, staphylococcus and the like, and has strong antiviral activity, so that the cordycepin has natural antibacterial, anti-inflammatory and antiviral effects in a toothpaste formula. Because the cordycepin is the main antibacterial component in the cordyceps militaris essence, the content of the cordycepin in the toothpaste formula is directly influenced by the addition amount of the cordyceps militaris essence.
The invention uses the cordyceps militaris sporocarp and the cordyceps militaris extract, so that the system contains various functional components such as cordycepin, cordycepic acid, polysaccharide, SOD enzyme and the like, and also contains the volatile components of the cordyceps militaris sporocarp per se, thereby the gum and tooth protecting effects are exerted to the best.
Propolis is a waxy resin produced by bees and is an antibacterial substance used by the bees to maintain the whole colony, and the propolis is complex in component and mainly contains beeswax, resin, aromatic volatile oil, flavonoid compounds and the like. The propolis extract is a water-soluble propolis extract obtained by alcohol extraction, has the original biological activity of propolis, plays various effects of resisting bacteria, resisting microorganisms, diminishing inflammation, resisting oxidation and the like, can treat infection of oral cavity and throat and prevent decayed teeth by using the toothpaste containing the propolis for a long time.
The manuka honey is medical honey produced from New Zealand and Australia, and has antibacterial, antifungal and antiviral activities. Compared with common honey, the manuka honey contains Methylglyoxal (MGO) with high concentration, and is divided by MGO content in a internationally accepted manuka honey grading system, and when the MGO content is higher, the antibacterial and health-care effects are better. In the invention, Manuka honey with MGO value not less than 263mg/kg is added into the toothpaste formula, and the toothpaste containing the honey has certain conditioning effect on oral ulcer, throat and intestines and stomach after long-term use.
O-cymene-5-alcohol is a broad-spectrum bactericide, has strong penetration sterilization effect, has good antibacterial effect on staphylococcus aureus, porphyromonas gingivalis and oral pathogenic bacteria, can penetrate into dental plaque to sterilize, is suitable for inflammation patients of gingivitis, periodontitis and the like, and can select commercially available products, such as Isopropyl methyl phenol of Nanjing Sbyaceae Biochemical industry Limited company.
Potassium nitrate, a desensitizing active ingredient in the United states Food and Drug Administration (FDA) monograph for tooth desensitization products, releases potassium ions, prevents the nerve endings of the dentinal tubules from being activated, and at sufficient potassium ion concentrations, prevents the nerve from being stimulated by the compressed dentin, reduces the permeability of the dentin, and thereby slows down dentin hypersensitivity.
The lemon tea tree oil is light yellow essential oil with fresh lemon fragrance, is obtained by a steam distillation extraction method, has main functional components of geranial and neral, has stronger bactericidal capability than the traditional tea tree oil, is a natural anti-inflammatory agent, has a smell different from the traditional bitter and spicy tea tree oil, and has the capabilities of calming, anti-allergy and anti-infection.
Aromatic holly, Agonis fragrans, mainly grows in the west region of Australia and belongs to the family Myrtaceae. The aromatic Chinese wolfberry leaf oil is an alcohol-sweet essential oil with slight spicy smell of cinnamon and is obtained by steam distillation of aromatic Chinese wolfberry leaves. The aromatic Chinese holly leaf oil is characterized in that three main active components (eucalyptol, pinene and alcohols) in the essential oil have a perfect golden triangle proportion, and because the three active components are perfectly combined, the aromatic Chinese holly leaf oil has multiple effects of resisting bacteria, diminishing inflammation, relieving pain, reducing phlegm and the like.
In the active anti-inflammatory toothpaste, multiple natural active ingredients such as cordyceps militaris essence, propolis extract, manuka honey, O-cymene-5-ol, lemon tea tree oil, aromatic Chinese holly leaf oil and the like have anti-inflammatory and bacteriostatic effects, and also have sedative and anti-allergy effects, so that various oral pathogenic bacteria can be efficiently resisted, oral diseases such as periodontitis, gingivitis and the like can be prevented, and the oral environment can be integrally improved. Multiple natural active ingredients and anti-allergy factor potassium salt are combined and jointly applied to the active anti-inflammation toothpaste, the active anti-inflammation toothpaste can be compounded and synergized, has remarkable anti-inflammation, antibacterial and anti-allergy effects, and can obviously improve oral problems such as oral ulcer, gingival inflammation, tooth allergy and the like after long-term use.
Preferably, the active anti-inflammatory toothpaste comprises the following preparation raw materials in percentage by weight: 0.1-5% of cordyceps militaris essence, 0.05-1% of propolis extract, 0.05-1% of manuka honey, 0.01-0.1% of O-cymene-5-ol, 3-10% of potassium nitrate, 0.02-1% of lemon tea tree oil and 0.02-1% of aromatic holly leaf oil.
Repeated research by the inventor shows that when the content of the cordyceps militaris essence is lower than 0.1%, the antibacterial effect is not obvious, and the antibacterial effect is enhanced along with the increase of the content of the cordyceps militaris essence, but when the content of the cordyceps militaris essence is higher than 5%, the antibacterial effect is not obviously increased along with the increase of the addition amount of the cordyceps militaris essence, and when the content of the cordyceps militaris essence is 0.1-5%, the cordyceps militaris essence has a good antibacterial effect; when the components are matched with each other at the ratio, the functions of diminishing inflammation, inhibiting bacteria and resisting sensitivity are obviously enhanced, and the problems of redness and swelling and bleeding of gum and sensitivity of teeth can be effectively reduced.
Preferably, the active anti-inflammatory toothpaste comprises the following preparation raw materials in percentage by weight: 0.5-3% of cordyceps militaris essence, 0.2-0.8% of propolis extract, 0.1-1% of manuka honey, 0.05-0.08% of O-cymene-5-ol, 3-5% of potassium nitrate, 0.1-0.5% of lemon tea tree oil and 0.1-0.5% of aromatic holly leaf oil.
The inventor repeatedly researches to obtain the compound anti-inflammatory and anti-allergic effects, and when the content of each component is the above content, the best anti-inflammatory and anti-allergic effects are achieved, and the problems of redness, swelling and bleeding of gum and sensitivity of teeth can be obviously improved.
Preferably, the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp is as follows: cordyceps militaris extract: and (3) cordyceps militaris fruit body 80-99.9: 0.01 to 20.
When the cordyceps militaris extract and the cordyceps militaris sporocarp are in the weight ratio, the cordyceps militaris extract and the cordyceps militaris sporocarp can fully play respective effects, so that a system contains cordycepin, cordycepic acid, polysaccharide, SOD enzyme and various volatile compounds, thereby achieving the effects of diminishing inflammation and sterilizing.
More preferably, the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp is as follows: cordyceps militaris extract: and (3) cordyceps militaris fruit body of 85-92: 8-15.
When the cordyceps militaris extract and the cordyceps militaris sporocarp are in the weight ratio, the toothpaste achieves the best sterilization effect.
Preferably, the preparation raw materials of the active anti-inflammatory toothpaste further comprise a humectant, an abrasive, a thickening agent and a foaming agent.
Preferably, in the preparation raw materials of the active anti-inflammatory toothpaste, the weight percentage of the humectant is 35-60%, the weight percentage of the abrasive is 14-30%, the weight percentage of the thickening agent is 0.5-3%, and the weight percentage of the foaming agent is 1.8-3%.
Preferably, the foaming agent is a mixture of sodium lauryl sulfate and at least one of an amino acid surfactant and an amphoteric surfactant.
More preferably, the foaming agent is a mixture of sodium lauryl sarcosinate, sodium lauroyl methyltaurate and cocamidopropyl betaine with sodium lauryl sulfate.
More preferably, the foaming agent is a mixture of sodium lauryl sarcosinate, sodium lauroyl methyltaurate and cocamidopropyl betaine with sodium lauryl sulfate.
The foaming agent is selected from commercial products, for example, sodium lauroyl sarcosinate can be selected from O L I-4208 of Shanghai Oroli, sodium lauroyl methyltaurate can be selected from O L I-4901 of Shanghai Oroli, cocamidopropyl betaine can be selected from CAPB DC of Galaxy Surfactants and L enotain C30 of Shanghai Li, wherein CAPB DC is particularly suitable.
Preferably, the abrasive is at least one of precipitated silica, ultrafine silica, calcium hydrogen phosphate, and calcium carbonate.
More preferably, the abrasive is a mixture of at least one of precipitated silica, calcium hydrogen phosphate and calcium carbonate and ultrafine silica, wherein the ultrafine silica accounts for 2-6 wt% of the raw materials for preparing the active anti-inflammatory toothpaste.
The weight percentage of the ultrafine silica in the raw materials for preparing the toothpaste is 2-6%, when the amount of the ultrafine silica is less than 2%, the surface of the paste is not smooth, the tooth brushing taste is poor, when the amount of the ultrafine silica is more than 6%, the paste is easy to harden out water at high temperature, and the stability is affected, the liquid absorption amount of the ultrafine silica is 30-44 ml/20g, preferably 30-38 ml/20g, and commercially available products, such as synthetic silica of the flying snow company, can be used, the liquid absorption amount of the precipitated silica is 15-25 ml/20g, preferably 18-22 ml/20g, precipitated calcite silica of the precipitated silica can be used, such as Zeodent115 of the BER company, the liquid absorption amount of calcium bicarbonate is 5.0-6.5 ml/20g, the apparent density is 0.80-1.00 g/m L, preferably the maximum value, and the apparent density tends to the minimum value, and commercially available products, such as calcium carbonate of the DEBONDA toothpaste, the liquid absorption amount of the calcium carbonate is 3.8.8 g, preferably 0.8.20 g/20 g, and the calcium carbonate powder of the commercially available from the DoPA company can be used.
Preferably, the thickener is at least one of sodium carboxymethylcellulose, carbomer and xanthan gum; the humectant is at least one of sorbitol, glycerol, polyethylene glycol and propylene glycol.
The sodium carboxymethylcellulose can be selected from commercially available products such as TH10 (toothpaste grade) from ASH L AND, with a degree of substitution of 0.75-1.02, preferably 0.95-1.02, AND cellulose with a 2% aqueous viscosity of 600-3000 mPa.s, preferably 1200-2500 mPa.s.Carboxymethylene can be selected from commercially available products such as L ubizol
PO L YMER (toothpaste grade), adjusting pH to about 7 (within the range of 6.5-7.5) with 25% NaOH solution, measuring viscosity with Brookfield RV6 rotor at 20rpm, and neutralizing water solution with viscosity of 0.6% of 15000-40000 mPa.s, preferably 20000-30000 mPa.s. xanthan gum, also called xanthan gum, and commercially available products such as CPKelco
Xanthan Gum (oral grade) with a viscosity of 1200-1600 mPas measured in a 1% KCl solution at 20rpm with a Brookfield RV6 rotor.
The active anti-inflammatory toothpaste of the invention can be added or used with other auxiliary materials, such as sweetening agents, pH regulators, spices, coloring agents, fluoride and the like, in addition to the specific requirements of the components, within the range of not damaging the effect of the invention, and the technicians in the field can select the common content according to the conventional standard.
Preferably, the active anti-inflammatory toothpaste further comprises the following components in percentage by mass: 0.1-2% of sweetening agent, 0.1-3% of pH regulator and 0.1-2% of spice.
Preferably, the sweetener is at least one of sodium saccharin, sucralose, and stevia; the spice is at least one of menthol, peppermint oil, spearmint oil, wintergreen oil, peppermint, sweet orange oil, lemon oil, anise oil and eucalyptus oil; the pH regulator is at least one of sodium hydroxide, anhydrous trisodium phosphate, sodium tripolyphosphate, alkaline phosphate and sodium dihydrogen phosphate.
The preparation method of the active anti-inflammatory toothpaste comprises the following steps:
(1) pre-dissolving potassium nitrate and auxiliary materials;
(2) premixing the friction agent and the thickening agent;
(3) adding the humectant and the materials in the step (1) into a paste preparation tank;
(4) opening a vacuum system of the cream making tank, vacuumizing, adding the mixture obtained in the step (2), cordyceps militaris essence, propolis extract, manuka honey, O-cymene-5-alcohol, potassium nitrate, lemon tea tree oil and aromatic holly leaf oil, and stirring and homogenizing under the condition of keeping the vacuum between-0.05 Mpa and-0.085 Mpa;
(5) adding foaming agent into the paste preparation tank, keeping the vacuum between-0.05 Mpa and-0.085 Mpa, and continuously stirring and homogenizing;
(6) degassing the paste preparation tank until the vacuum degree is-0.092 Mpa to-0.098 Mpa, and discharging paste to obtain the active anti-inflammatory toothpaste.
The invention has the beneficial effects that: the active anti-inflammatory toothpaste provided by the invention contains multiple natural extracts, and under the combined action of active ingredients of the multiple natural extracts, the active anti-inflammatory toothpaste has a remarkable anti-inflammatory and antibacterial effect, can efficiently resist various oral pathogenic bacteria, prevent oral diseases such as periodontitis and gingivitis, integrally improve the oral environment, and obviously improve oral problems such as oral ulcer, gingival inflammation and tooth allergy after long-term use.
Drawings
FIG. 1 is a comparison graph of the bacteriostasis test of the toothpastes of example 5 and comparative examples 1-7 on Staphylococcus aureus;
FIG. 2 is a comparison graph of the bacteriostatic tests of the toothpastes of example 5 and comparative examples 1 to 7 on Streptococcus mutans;
FIG. 3 is a comparison chart of the bacteriostasis test of the toothpastes of example 5 and comparative examples 1-7 on the porphyromonas gingivalis.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Example 1
One embodiment of the active anti-inflammatory toothpaste comprises the following preparation raw materials in percentage by weight: 0.1% of cordyceps militaris essence, 0.05% of propolis extract, 0.05% of manuka honey, 0.01% of O-cymene-5-ol, 3% of potassium nitrate, 0.02% of lemon tea tree oil, 0.02% of aromatic holly leaf oil, 60% of humectant, 14% of abrasive, 0.5% of thickener, 1.8% of foaming agent, 0.1% of sweetener, 0.1% of pH regulator, 0.1% of perfume and the balance of deionized water;
the cordyceps militaris essence is a mixture of cordyceps militaris extract and cordyceps militaris fruiting body, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris fruiting body is as follows: cordyceps militaris extract: cordyceps militaris fruit body 99.9: 0.01; the humectant is sorbitol; the thickening agent is sodium carboxymethyl cellulose; the foaming agent is a mixture of sodium lauroyl sarcosinate and sodium dodecyl sulfate; the mixture of the abrasive precipitated silica and the superfine silica accounts for 2 percent of the weight of the superfine silica in the raw materials for preparing the active anti-inflammatory toothpaste; the sweetener is saccharin sodium; the spice is menthol; the pH regulator is alkaline phosphate and sodium dihydrogen phosphate.
Example 2
One embodiment of the active anti-inflammatory toothpaste comprises the following preparation raw materials in percentage by weight: 5% of cordyceps militaris essence, 1% of propolis extract, 1% of manuka honey, 0.05-0.1% of O-cymene-5-ol, 10% of potassium nitrate, 1% of lemon tea tree oil, 1% of aromatic holly leaf oil, 35% of humectant, 20% of abrasive, 3% of thickener, 3% of foaming agent, 2% of sweetener, 3% of pH regulator, 2% of perfume and the balance of deionized water;
the cordyceps militaris essence is a mixture of cordyceps militaris extract and cordyceps militaris fruiting body, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris fruiting body is as follows: cordyceps militaris extract: cordyceps militaris fruit body 80: 20; the humectant is a mixture of sorbitol and glycerol; the thickening agent is a mixture of sodium carboxymethylcellulose and carbomer; the foaming agent is a mixture of sodium lauroyl methyl taurate and sodium dodecyl sulfate; the abrasive is a mixture of calcium hydrophosphate and superfine silicon dioxide, and the weight percentage of the superfine silicon dioxide in the preparation raw materials of the active anti-inflammatory toothpaste is 6%; the sweetener is sucralose; the spice is spearmint oil; the pH regulator is sodium hydroxide.
Example 3
One embodiment of the active anti-inflammatory toothpaste comprises the following preparation raw materials in percentage by weight: 0.5% of cordyceps militaris essence, 0.2% of propolis extract, 0.1% of manuka honey, 0.05% of O-cymene-5-ol, 3% of potassium nitrate, 0.1% of lemon tea tree oil, 0.1-1% of aromatic holly leaf oil, 40% of humectant, 30% of friction agent, 0.5% of thickening agent, 1.8% of foaming agent, 0.1% of sweetening agent, 0.1% of pH regulator, 0.1% of perfume and the balance of deionized water;
the cordyceps militaris essence is a mixture of cordyceps militaris extract and cordyceps militaris fruiting body, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris fruiting body is as follows: cordyceps militaris extract: cordyceps militaris fruit body 92: 8; the humectant is a mixture of sorbitol and propylene glycol; the thickening agent is a mixture of sodium carboxymethylcellulose and xanthan gum; the foaming agent is a mixture of cocamidopropyl betaine and sodium lauryl sulfate; the abrasive is a mixture of calcium carbonate and superfine silicon dioxide, and the weight percentage of the superfine silicon dioxide in the raw materials for preparing the active anti-inflammatory toothpaste is 4%; the sweetener is stevia rebaudiana; the spice is lemon oil; the pH regulator is anhydrous trisodium phosphate.
Example 4
One embodiment of the active anti-inflammatory toothpaste comprises the following preparation raw materials in percentage by weight: 3% of cordyceps militaris essence, 0.8% of propolis extract, 0.5% of manuka honey, 0.08% of O-cymene-5-ol, 5% of potassium nitrate, 0.5% of lemon tea tree oil, 0.5% of aromatic holly leaf oil, 45% of humectant, 20% of abrasive, 2% of thickening agent, 2% of foaming agent, 1% of sweetener, 2% of pH regulator, 1% of perfume and the balance of deionized water;
the cordyceps militaris essence is a mixture of cordyceps militaris extract and cordyceps militaris fruiting body, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris fruiting body is as follows: cordyceps militaris extract: cordyceps militaris fruit body 85: 15; the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and superfine silica, and the weight percentage of the superfine silica in the raw materials for preparing the active anti-inflammatory toothpaste is 6%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Example 5
One embodiment of the active anti-inflammatory toothpaste comprises the following preparation raw materials in percentage by weight: 2.5% of cordyceps militaris essence, 0.5% of propolis extract, 0.5% of manuka honey, 0.08% of O-cymene-5-ol, 5% of potassium nitrate, 0.5% of lemon tea tree oil, 0.5% of aromatic holly leaf oil, 50% of humectant, 22% of abrasive, 2% of thickening agent, 2% of foaming agent, 1% of sweetener, 2% of pH regulator, 1% of perfume and the balance of deionized water;
the cordyceps militaris essence is a mixture of cordyceps militaris extract and cordyceps militaris fruiting body, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris fruiting body is as follows: cordyceps militaris extract: cordyceps militaris fruit body 90: 10; the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the raw materials for preparing the active anti-inflammatory toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Example 6
According to an embodiment of the active anti-inflammatory toothpaste, the active anti-inflammatory toothpaste is different from the active anti-inflammatory toothpaste in the embodiment 5 only in the content of cordyceps militaris essence, and the cordyceps militaris essence of the active anti-inflammatory toothpaste in the embodiment accounts for 5% by weight of the raw materials for preparing the toothpaste.
Example 7
According to an embodiment of the active anti-inflammatory toothpaste, the active anti-inflammatory toothpaste in the embodiment is different from the active anti-inflammatory toothpaste in the embodiment 5 only in content of cordyceps militaris essence, and the cordyceps militaris essence of the active anti-inflammatory toothpaste in the embodiment accounts for 4% by weight of raw materials for preparing the toothpaste.
Example 8
According to an embodiment of the active anti-inflammatory toothpaste, the active anti-inflammatory toothpaste in the embodiment is different from the active anti-inflammatory toothpaste in the embodiment 5 only in content of cordyceps militaris essence, and the cordyceps militaris essence of the active anti-inflammatory toothpaste in the embodiment accounts for 2% by weight of raw materials for preparing the toothpaste.
Example 9
According to an embodiment of the active anti-inflammatory toothpaste, the active anti-inflammatory toothpaste in the embodiment is different from the active anti-inflammatory toothpaste in the embodiment 5 only in content of cordyceps militaris essence, and the cordyceps militaris essence of the active anti-inflammatory toothpaste in the embodiment accounts for 1% by weight of raw materials for preparing the toothpaste.
Example 10
According to an embodiment of the active anti-inflammatory toothpaste, the active anti-inflammatory toothpaste in the embodiment is different from the active anti-inflammatory toothpaste in the embodiment 5 only in content of cordyceps militaris essence, and the cordyceps militaris essence of the active anti-inflammatory toothpaste in the embodiment accounts for 0.1% of the weight of the raw materials for preparing the toothpaste.
Example 11
According to an embodiment of the active anti-inflammatory toothpaste, the preparation raw materials of the toothpaste are different from those of the toothpaste of embodiment 5 only in the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp is as follows: cordyceps militaris extract: cordyceps militaris fruit body 99.9: 0.01.
example 12
According to an embodiment of the active anti-inflammatory toothpaste, the preparation raw materials of the toothpaste are different from those of the toothpaste of embodiment 5 only in the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp is as follows: cordyceps militaris extract: cordyceps militaris fruit body 95: 5.
example 13
According to an embodiment of the active anti-inflammatory toothpaste, the preparation raw materials of the toothpaste are different from those of the toothpaste of embodiment 5 only in the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp is as follows: cordyceps militaris extract: cordyceps militaris fruit body 92: 8.
example 14
According to an embodiment of the active anti-inflammatory toothpaste, the preparation raw materials of the toothpaste are different from those of the toothpaste of embodiment 5 only in the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp is as follows: cordyceps militaris extract: cordyceps militaris fruit body 85: 15.
example 15
According to an embodiment of the active anti-inflammatory toothpaste, the preparation raw materials of the toothpaste are different from those of the toothpaste of embodiment 5 only in the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp is as follows: cordyceps militaris extract: cordyceps militaris fruit body 80: 20.
comparative example 1
The preparation raw materials of the toothpaste comprise no cordyceps militaris essence, no propolis extract, manuka honey, O-cymene-5-ol, lemon tea tree oil and aromatic holly leaf oil, namely the toothpaste comprises the following preparation raw materials in percentage by weight: 5% of potassium nitrate, 50% of a humectant, 22% of an abrasive, 2% of a thickening agent, 2% of a foaming agent, 1% of a sweetening agent, 2% of a pH regulator, 1% of a perfume and the balance of deionized water;
wherein the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the raw materials for preparing the active anti-inflammatory toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Comparative example 2
The preparation raw materials of the toothpaste of the invention are different from those of the toothpaste of the embodiment 5 in that the preparation raw materials of the toothpaste of the invention do not contain propolis extract, manuka honey, O-cymene-5-ol, lemon tea tree oil and aromatic holly leaf oil, namely the toothpaste of the invention comprises the following preparation raw materials in percentage by weight: 2.5% of cordyceps militaris essence, 5% of potassium nitrate, 50% of humectant, 22% of abrasive, 2% of thickener, 2% of foaming agent, 1% of sweetener, 2% of pH regulator, 1% of perfume and the balance of deionized water;
wherein the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the raw materials for preparing the active anti-inflammatory toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Comparative example 3
The preparation raw materials of the toothpaste of the invention are different from those of the toothpaste of the embodiment 5 in that the preparation raw materials of the toothpaste of the invention do not contain cordyceps militaris essence, manuka honey, O-cymene-5-ol, lemon tea tree oil and aromatic holly leaf oil, namely the toothpaste of the invention comprises the following preparation raw materials in percentage by weight: 0.5% of propolis extract, 5% of potassium nitrate, 50% of humectant, 22% of abrasive, 2% of thickener, 2% of foaming agent, 1% of sweetener, 2% of pH regulator, 1% of perfume and the balance of deionized water;
wherein the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the raw materials for preparing the active anti-inflammatory toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Comparative example 4
The preparation raw materials of the toothpaste of the invention are different from those of the toothpaste of the embodiment 5 in that the preparation raw materials of the toothpaste of the invention do not contain cordyceps militaris essence, propolis extract, manuka honey, lemon tea tree oil and aromatic holly leaf oil, namely the toothpaste of the invention comprises the following preparation raw materials in percentage by weight: 0.08% of O-cymene-5-alcohol, 5% of potassium nitrate, 50% of humectant, 22% of abrasive, 2% of thickening agent, 2% of foaming agent, 1% of sweetener, 2% of pH regulator, 1% of perfume and the balance of deionized water;
wherein the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the raw materials for preparing the active anti-inflammatory toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Comparative example 5
The invention relates to a comparative example of active anti-inflammation toothpaste, which is different from the toothpaste prepared in example 5 in that the raw materials for preparing the toothpaste do not contain cordyceps militaris essence, propolis extract, manuka honey, O-cymene-5-alcohol and aromatic holly leaf oil, namely the toothpaste comprises the following raw materials in percentage by weight: 0.5% of lemon tea tree oil, 5% of potassium nitrate, 50% of humectant, 22% of abrasive, 2% of thickening agent, 2% of foaming agent, 1% of sweetening agent, 2% of pH regulator, 1% of perfume and the balance of deionized water;
wherein the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the raw materials for preparing the active anti-inflammatory toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Comparative example 6
The preparation raw materials of the toothpaste comprise no cordyceps militaris essence, no propolis extract, no O-cymene-5-ol, no lemon tea tree oil and no aromatic Chinese holly leaf oil, namely the toothpaste comprises the following preparation raw materials in percentage by weight: 0.5% of manuka honey, 5% of potassium nitrate, 50% of humectant, 22% of abrasive, 2% of thickener, 2% of foaming agent, 1% of sweetener, 2% of pH regulator, 1% of perfume and the balance of deionized water;
wherein the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the raw materials for preparing the active anti-inflammatory toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Comparative example 7
The preparation raw materials of the toothpaste comprise no cordyceps militaris essence, no propolis extract, manuka honey, O-cymene-5-alcohol and lemon tea tree oil, namely the toothpaste comprises the following preparation raw materials in percentage by weight: 0.5% of aronia leaf oil, 5% of potassium nitrate, 50% of humectant, 22% of abrasive, 2% of thickening agent, 2% of foaming agent, 1% of sweetening agent, 2% of pH regulator, 1% of perfume and the balance of deionized water;
wherein the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the raw materials for preparing the active anti-inflammatory toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Comparative example 8
The preparation raw materials of the active anti-inflammatory toothpaste disclosed by the invention are different from those of the toothpaste in example 5 only in the content of cordyceps militaris essence, and the cordyceps militaris essence of the active anti-inflammatory toothpaste disclosed by the invention accounts for 6 wt% of the preparation raw materials of the toothpaste.
Comparative example 9
The preparation raw materials of the toothpaste of the comparative example are different from those of the toothpaste of the example 5 only in the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp of the comparative example is as follows: cordyceps militaris extract: the ratio of cordyceps militaris fruit body is 100: 0.
Comparative example 10
The preparation raw materials of the toothpaste of the comparative example are different from those of the toothpaste of the example 5 only in the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp of the comparative example is as follows: cordyceps militaris extract: the ratio of cordyceps militaris fruit body is 75: 25.
Example 16
Bacteriostatic tests are carried out on the active anti-inflammatory toothpaste disclosed in examples 1-15 and the toothpaste disclosed in comparative examples 1-10 against several common bacteria in the oral cavity.
The bacteriostasis test method comprises the following steps: the test was carried out by a third party agency according to the test method for resistance (inhibition) of Disinfection Specification 2.1.8.
Preparing the bacteriostatic tablets: preparing bacteriostatic agent raw paste sheets with the diameter of 5mm and the thickness of no more than 4mm in a clean sterile plate, and grouping every 4 sheets (blocks).
Preparation of negative pair photographs: taking a sterile dry filter paper sheet, and dripping sterile distilled water into each sheet for later use.
Inoculation of test bacteria by dipping with sterile cotton swab at 5 × 10 concentration5cfu/ml～5×106The cfu/ml test bacterial suspension is evenly smeared on the surface of a nutrient agar medium flat plate for 3 times, the flat plate should rotate 60 degrees every time the smearing is carried out for 1 time, finally, a cotton swab is smeared for a circle around the edge of the flat plate, the flat plate is covered, and the room temperature is kept for drying for 5 min.
Sticking bacteriostatic agent sample pieces: each test is stuck with 1 infectious bacterium plate, each plate is stuck with 4 test sample plates of the same test group, 1 negative pair photo, and 5 negative pair photos. A sample was taken with sterile forceps and placed on the surface of the plate. The distance between the centers of the various pieces is more than 25mm, and the distance between the centers of the various pieces and the periphery of the flat plate is more than 15 mm. After the sample is placed, the sample is lightly pressed by using sterile tweezers to be tightly attached to the surface of the flat plate. The plate is covered, the plate is placed in an incubator at 37 ℃, and the result is observed after the plate is cultured for 16 to 18 hours. The direct measurement of the zone of inhibition was measured with a vernier caliper and recorded, and the test was repeated 3 times.
The strains tested at this time selected common oral pathogens: staphylococcus aureus, streptococcus mutans, and porphyromonas gingivalis.
And (3) bacteriostatic test evaluation standard: if the diameter of the bacteriostatic ring is larger than 7mm, the bacteriostatic ring is judged to have bacteriostatic action; if the diameter of the antibacterial ring is less than or equal to 7mm, the product is judged to have no antibacterial effect. The results of the bacteriostatic tests of the toothpastes in the examples 1 to 10 and the comparative examples 1 to 8 are shown in table 1, the results of the bacteriostatic tests of the toothpastes in the example 5 and the comparative examples 1 to 7 are shown in attached figures 1 to 3, and the results of the bacteriostatic tests of the toothpastes in the examples 5, 11 to 15 and the comparative examples 9 and 10 are shown in table 2.
TABLE 1 results of bacteriostatic tests on toothpastes described in examples 1 to 10 and comparative examples 1 to 8
As can be seen from table 1, the antibacterial effect of the active anti-inflammatory toothpaste described in examples 1 to 10 is superior to that of the toothpaste described in comparative examples 1 to 8, and especially, as can be seen from comparison of the antibacterial effect of example 5 and that of comparative examples 1 to 7 in fig. 1 to 3, the antibacterial effect of example 5 is greater than that of the toothpaste prepared by adding only one or more of cordyceps militaris essence, propolis extract, manuka honey, O-cymene-5-ol, potassium nitrate, lemon tea tree oil and aromatic holly leaf oil, which indicates that the compounding of cordyceps militaris essence, propolis extract, manuka honey, O-cymene-5-ol, potassium nitrate, lemon tea tree oil and aromatic holly leaf oil in a certain proportion range can play a synergistic role. From the antibacterial effect comparative examples of the embodiments 5-10 and the comparative example 8, it can be obtained that the antibacterial effect is increased along with the increase of the addition amount of the cordyceps militaris essence, but compared with the embodiment 6, the addition amount of the comparative example 8 is increased by 1%, but the antibacterial effect is not obviously increased.
TABLE 2 results of bacteriostatic tests on toothpastes according to examples 5, 11-15 and comparative examples 9, 10
As can be seen from table 2, under the condition of a certain content of the essence of cordyceps militaris, the antibacterial effect of the prepared toothpaste tends to increase and decrease with the increase of the content of the fruiting body of cordyceps militaris, and the weight ratio of the extract of cordyceps militaris to the fruiting body of cordyceps militaris is as follows: cordyceps militaris extract: and (3) cordyceps militaris fruit body of 85-92: the best effect is achieved when the temperature is 8-15 ℃.
Example 16
Clinical tests are carried out on the active anti-inflammatory toothpaste disclosed by the invention and the toothpastes disclosed in comparative examples 1-7, and the specific test scheme is as follows:
first, test scheme
The design of a random double-blind control test is characterized in that 201 volunteer subjects suffering from gingival red swelling and bleeding problems of different degrees are collected, the ages of the volunteer subjects are 18-60 years old, the volunteer subjects are randomly divided into a test group I-VII, a control group II-25 volunteer, a control group III-24 volunteer, a control group IV-25 volunteer, a control group V-24 volunteer, a control group VI 26 and a control group VII-25 volunteer, the test group and the control groups I, II, III, IV, V, VI and VII respectively use the toothpaste with the activity and the inflammation diminishing function and the toothpastes of the comparative examples 1-7, and the related indexes of teeth and gingiva of the volunteer subjects using the toothpastes are checked by adopting a method of oral epidemiological investigation.
Second, use method
Toothbrush: a soft-filament toothbrush;
dosage: the test subjects and the control subjects I-V in the test group and the control group brush teeth 2 times in the morning and at the evening every day, and 2 g of toothpaste is used each time.
Third, observe the item and index
1. Gingival Index (GI)
The conditions of 4 areas of the gingival margin at the mesial, distal, buccal and lingual sides are inspected, and the standard is 0-3 grade, and the standard is 0 grade (the gingiva is normal); 1 point (slight inflammation of gingiva, slight change of color, mild edema, no bleeding in probing); 2 points (moderate inflammation of gingiva, red, edema, brightness, probing bleeding); and 3 points (obvious gingival inflammation, red swelling, ulcer and tendency of automatic bleeding).
2. Gingival Sulcus Bleeding Index (SBI)
The gingival margin is inspected in 4 areas of the mesial, distal, buccal and lingual sides and classified into 4 grades and 1 (no bleeding); 2 points (bleeding when the gingival sulcus is slightly explored, the appearance of the gingiva is normal); 3 points (bleeding when probing gingival sulcus, reddened gingiva and no swelling); and 4 points (gum ulcerated or otherwise).
3. Plaque index (P L I)
Grading 4 according to the amount of bacterial plaque, 0 (no bacterial plaque in the gingival margin); 1 point (no plaque is detected by visual inspection, but a thin layer of plaque can be scraped in a free gum and the adjacent area by a probe); 2 points (moderate accumulation of soft deposits can be seen in the pocket, free gum area or adjacent tooth surface); 3 points (large soft deposits in the gingival pocket or free gingival area and adjacent tooth surface).
Fourth, test results
GI. The values of SBI and P L I are the average value of the conditions of the volunteer subjects in each group, and the test results are shown in tables 3-5.
TABLE 3 comparison of GI values of test and control groups
TABLE 4 comparison of SBI values of test and control groups
| Test set | Before the experiment | After 4 weeks | After 8 weeks |
| Test group | 3.45±0.49 | 2.06±0.39 | 1.21±0.50 |
| Control group I | 3.40±0.61 | 3.30±0.51 | 3.13±0.42 |
| Control group II | 3.69±0.40 | 3.01±0.42 | 2.64±0.36 |
| Control group III | 3.23±0.65 | 2.60±0.55 | 2.36±0.45 |
| Control group IV | 3.69±0.50 | 2.93±0.58 | 2.62±0.46 |
| Control group V | 3.21±0.51 | 2.50±0.61 | 2.29±0.40 |
| Control group VI | 3.33±0.50 | 2.69±0.43 | 2.25±0.44 |
| Control group VII | 3.12±0.66 | 2.41±0.39 | 2.22±0.40 |
TABLE 5 comparison of P L I values for test and control groups
As can be seen from tables 3 to 5, compared with the toothpaste prepared by adding one or more of cordyceps militaris essence, propolis extract, manuka honey, O-cymene-5-ol, potassium nitrate, lemon tea tree oil and aromatic holly leaf oil in comparative examples 1 to 7, the active anti-inflammatory toothpaste disclosed by the invention can be used for effectively treating gingivitis, treating gingival bleeding more effectively, diminishing inflammation and relieving pain, and compared with a control group, the active anti-inflammatory toothpaste has a significant difference (P is less than 0.05).
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (9)
1. The active anti-inflammation toothpaste is characterized by comprising the following preparation raw materials in percentage by weight: 0.1-5% of cordyceps militaris essence, 0.05-1% of propolis extract, 0.05-1% of manuka honey, 0.01-0.1% of O-cymene-5-ol, 3-10% of potassium nitrate, 0.02-1% of lemon tea tree oil and 0.02-1% of aromatic holly leaf oil; the cordyceps militaris essence is a mixture of cordyceps militaris extract and cordyceps militaris sporocarp; the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp is as follows: cordyceps militaris extract: and (3) cordyceps militaris fruit body of 85-92: 8-15.
2. The active anti-inflammatory toothpaste according to claim 1, wherein the active anti-inflammatory toothpaste comprises the following preparation raw materials in percentage by weight: 0.5-3% of cordyceps militaris essence, 0.2-0.8% of propolis extract, 0.1-1% of manuka honey, 0.05-0.08% of O-cymene-5-ol, 3-5% of potassium nitrate, 0.1-0.5% of lemon tea tree oil and 0.1-0.5% of aromatic holly leaf oil.
3. The active anti-inflammatory toothpaste according to claim 1 wherein said active anti-inflammatory toothpaste is prepared from ingredients further comprising a humectant, an abrasive, a thickener, and a foaming agent.
4. The active anti-inflammatory toothpaste according to claim 3, wherein the active anti-inflammatory toothpaste is prepared from 35 to 60 weight percent of the humectant, 14 to 30 weight percent of the abrasive, 0.5 to 3 weight percent of the thickener and 1.8 to 3 weight percent of the foaming agent.
5. The active anti-inflammatory dentifrice of claim 3 wherein said foaming agent is a mixture of sodium lauryl sulfate and at least one of an amino acid surfactant and an amphoteric surfactant.
6. The active anti-inflammatory dentifrice of claim 3 wherein said foaming agent is a mixture of sodium lauryl sulfate and at least one of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and cocamidopropyl betaine.
7. The active anti-inflammatory dentifrice of claim 3 wherein said abrasive agent is at least one of precipitated silica, ultra fine silica, calcium hydrogen phosphate and calcium carbonate.
8. The active anti-inflammatory toothpaste according to claim 7, wherein the abrasive is a mixture of at least one of precipitated silica, calcium hydrogen phosphate and calcium carbonate and ultrafine silica, wherein the active anti-inflammatory toothpaste is prepared from the raw materials in an amount of 2-6% by weight of the ultrafine silica.
9. The active anti-inflammatory dentifrice of claim 3 wherein said thickening agent is at least one of sodium carboxymethylcellulose, carbomer and xanthan gum; the humectant is at least one of sorbitol, glycerol, polyethylene glycol and propylene glycol.
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| CN108125897A (en) * | 2018-02-11 | 2018-06-08 | 陕西杨凌陕特农业发展有限公司 | A kind of hypo-allergenic promoting and tooth-building toothpaste of children |
| CN108836888A (en) * | 2018-04-25 | 2018-11-20 | 佛山科学技术学院 | A kind of tooth antiallergic composition |
| CN109287676A (en) * | 2018-11-13 | 2019-02-01 | 沈阳秉弘环保科技有限公司 | A kind of antibacterial mite-removing removes the aqueous solution of peculiar smell |
| CN110772475A (en) * | 2019-12-10 | 2020-02-11 | 广州瑞誉化工科技有限公司 | Probiotic toothpaste |
| CN111617021B (en) * | 2020-07-07 | 2022-07-22 | 上海芒歌科技有限公司 | Toothpaste for resisting oral helicobacter pylori |
| CN113069405A (en) * | 2021-04-27 | 2021-07-06 | 广州优妥生物科技有限公司 | Antibacterial toothpaste for relieving oral ulcer and preparation method thereof |
| CN115025022B (en) * | 2022-07-13 | 2023-09-05 | 湖南互美电子商务有限公司 | Antibacterial toothpaste and preparation method thereof |
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