CN107468553B - Dental caries prevention toothpaste - Google Patents
Dental caries prevention toothpaste Download PDFInfo
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- CN107468553B CN107468553B CN201710635737.4A CN201710635737A CN107468553B CN 107468553 B CN107468553 B CN 107468553B CN 201710635737 A CN201710635737 A CN 201710635737A CN 107468553 B CN107468553 B CN 107468553B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The invention discloses a dental caries prevention toothpaste, which comprises cordyceps militaris essence, sodium monofluorophosphate, calcium glycerophosphate, O-cymene-5-alcohol, potassium nitrate and natural sugar alcohol. In the anti-caries toothpaste, the cordyceps militaris essence and a plurality of substances with anti-caries efficacy are compounded and cooperated together, so that the anti-caries toothpaste has remarkable anti-inflammation, anti-bacteria and anti-caries effects.
Description
Technical Field
The invention relates to toothpaste, in particular to toothpaste for preventing dental caries.
Background
Caries is always a common and primary oral problem, caries protection must be done for people of all ages, otherwise, caries can affect the problem of daily food chewing, meanwhile, tissues such as tooth roots and the like are easy to generate inflammation and swelling, and oral diseases such as pulpitis, periodontitis and the like occur in succession. Dental caries is a disease caused by four-linked factors, including four linked factors of bacteria, oral environment, host and time. Wherein bacteria are a necessary condition for the development of caries. Cariogenic bacteria are of two types, one is acidogenic bacteria, mainly including streptococcus mutans (s.mutans), lactobacillus and other acidogenic bacteria, and can decompose carbohydrate to produce acid, resulting in progressive tissue loss, tooth demineralization and finally formation of caries. The other is gram-positive cocci which can destroy organic matters and cause the tooth to form a cavity after long-term action. Therefore, killing bacteria adhering to the tooth surface is critical for caries prevention.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide the toothpaste for preventing dental caries.
In order to achieve the purpose, the invention adopts the technical scheme that: a toothpaste for preventing dental caries comprises scarlet caterpiller fungus essence, sodium monofluorophosphate, calcium glycerophosphate, O-cymene-5-ol, potassium nitrate and natural sugar alcohol; the Cordyceps militaris essence is a mixture of Cordyceps militaris extract and Cordyceps militaris fruiting body.
The cordyceps militaris is edible fungus used as both medicine and food, and the cordyceps militaris extract can be purchased in the market and also can be a refined extract obtained by carrying out water extraction and alcohol precipitation on cordyceps militaris fruiting bodies. The Cordyceps militaris fruiting body is obtained by inoculating Cordyceps militaris strain on solid culture medium, culturing for a certain period of time, developing and differentiating mycelium to form orange rod-shaped stroma (fruiting body), collecting fresh fruiting body, air drying, and grinding; the mixture of the two is the cordyceps militaris essence, and the active ingredient, cordycepin, contained in the cordyceps militaris essence can effectively kill cariogenic bacteria adhered to tooth surfaces, so that the effects of sterilization and caries prevention are achieved. Because cordycepin is the main antibacterial component in the cordyceps militaris extract, the content of cordycepin in the toothpaste formula is directly influenced by the addition amount of cordyceps militaris essence.
The cordyceps militaris sporocarp provided by the invention is composed of substances such as water, ash, protein and fat, contains various volatile compounds, contains more aromatic aldehyde substances, and has certain antibacterial and anti-inflammatory effects, but the aromatic volatile components cannot be retained for more than one hour at the extraction temperature of 50 ℃. Therefore, the volatile components of the cordyceps militaris sporocarp can completely enter a toothpaste system by adding the cordyceps militaris sporocarp.
Cordycepin, the first nucleoside antibiotic separated from fungi, has a molecular structure of 3-deoxyadenosine, has a broad-spectrum antibacterial effect, and is found to be capable of inhibiting the growth of pathogenic bacteria such as streptococcus, staphylococcus and the like, and has strong antiviral activity, so that the cordycepin has natural antibacterial, anti-inflammatory and antiviral effects in a toothpaste formula. Because the cordycepin is the main antibacterial component in the cordyceps militaris extract, the content of the cordycepin in the toothpaste formula is directly influenced by the addition amount of the cordyceps militaris essence.
The invention uses the cordyceps militaris sporocarp and the cordyceps militaris extract, so that the system contains various functional components such as cordycepin, cordycepic acid, polysaccharide, SOD enzyme and the like, and also contains the volatile components of the cordyceps militaris sporocarp per se, thereby the efficacy of preventing caries and protecting teeth is exerted to the best.
The fluorine-containing toothpaste is used, and the fluoride ions of the toothpaste can exchange with hydroxide ions in hydroxyapatite of enamel to form more acid-resistant fluorapatite, so that the acid resistance of the whole enamel is improved.
Calcium glycerophosphate is used in medicine to promote the calcification of bone and teeth, to replenish calcium for teeth and to strengthen teeth. Aiming at the oral cavity formula, the calcium glycerophosphate also has the effects of resisting bacteria and preventing caries, can improve the contents of calcium and phosphorus in tooth enamel, inhibit the demineralization of the tooth enamel and improve the remineralization of the tooth enamel.
O-cymene-5-ol is a broad-spectrum bacteriostatic agent, has strong bactericidal action, has good antibacterial effect on oral pathogenic bacteria such as staphylococcus aureus, porphyromonas gingivalis and the like, can permeate into dental plaque to sterilize, is suitable for inflammation patients such as gingivitis, periodontitis and the like, and can be selected from commercially available products, such as Isopropyl methyl phenol of Nanjing Spaikagaceae Biochemical industry Limited company.
Potassium nitrate, a desensitizing active ingredient in the United states Food and Drug Administration (FDA) monograph for tooth desensitization products, releases potassium ions, prevents the nerve endings of the dentinal tubules from being activated, and at sufficient potassium ion concentrations, prevents the nerve from being stimulated by the compressed dentin, reduces the permeability of the dentin, and thereby slows down dentin hypersensitivity.
According to the anti-caries toothpaste, the cordyceps militaris essence and various substances with the anti-caries effect are matched for use, so that the anti-caries toothpaste has a remarkable anti-inflammation and anti-bacteria effect, a strong anti-caries effect is achieved, the anti-inflammation and anti-caries effects are remarkably enhanced, caries is comprehensively prevented under the synergistic effect of the cordyceps militaris essence and multiple anti-caries components, teeth are strengthened, and the anti-caries toothpaste is suitable for sensitive teeth patients.
Preferably, in the preparation raw materials of the anti-caries toothpaste, the cordyceps militaris essence is 0.1-5 wt%, the calcium glycerophosphate is 0.1-0.8 wt%, the O-cymene-5-ol is 0.01-0.1 wt%, the potassium nitrate is 3-10 wt%, and the natural sugar alcohol is 0.5-10 wt%.
Repeated research by the inventor shows that when the content of the cordyceps militaris essence is lower than 0.1%, the antibacterial effect of the toothpaste is not obvious, the antibacterial effect is enhanced along with the increase of the content of the cordyceps militaris essence, but when the content of the cordyceps militaris essence is higher than 5%, the antibacterial effect is not obviously increased along with the increase of the addition amount of the cordyceps militaris essence, and when the content of the cordyceps militaris essence is 0.1-5%, the toothpaste has a good antibacterial effect; when the components are matched with each other in the proportion, the anti-inflammatory and antibacterial effects and the anti-caries effect are obviously enhanced, under the synergistic effect of cordyceps militaris essence and multiple anti-caries components, the dental caries can be effectively prevented from being continuously diseased, and the anti-inflammatory and antibacterial effects and the strengthening of teeth are achieved, and meanwhile, the tooth-strengthening toothpaste is suitable for being used by sensitive teeth patients.
More preferably, in the preparation raw materials of the caries-prevention toothpaste, the cordyceps militaris essence accounts for 0.5-3 wt%, the calcium glycerophosphate accounts for 0.1-0.5 wt%, the O-cymene-5-ol accounts for 0.05-0.08 wt%, the potassium nitrate accounts for 3-5 wt%, and the natural sugar alcohol accounts for 0.5-5 wt%.
Through repeated research of the inventor, when the components are in the content, the toothpaste has the best anti-inflammatory and bactericidal effect and the best anti-caries effect.
Preferably, the fluoride concentration provided by the dental caries prevention toothpaste is 850-1500 mg/kg.
When the concentration of the fluorine-containing ions in the toothpaste for preventing dental caries is within the range, the toothpaste can play a better role in preventing dental caries.
Preferably, the fluoride is at least one of sodium fluoride, sodium monofluorophosphate and stannous fluoride; the natural sugar alcohol is erythritol and/or xylitol.
The fluoride provided by the invention can be at least one of sodium fluoride, sodium monofluorophosphate and stannous fluoride, which are safe and ideal fluorides. For example, when the sodium fluoride is used in the dental caries prevention toothpaste independently, the weight percentage of the sodium fluoride in the dental caries prevention toothpaste is 0.18-0.33%, when the sodium monofluorophosphate is used in the dental caries prevention toothpaste independently, the weight percentage of the sodium monofluorophosphate in the dental caries prevention toothpaste is 0.654-1.153%, when the stannous fluoride is used in the dental caries prevention toothpaste independently, the weight percentage of the stannous fluoride in the dental caries prevention toothpaste is 0.35-0.62%, and multiple fluorides can be used in a compounding manner according to requirements.
The xylitol and the erythritol belong to natural sugar alcohols, can be used as functional sweeteners, and are suitable for diabetes patients. The two natural sugar alcohols also have the functions of preventing and treating dental caries, and compared with pure sorbitol, erythritol and/or xylitol are added in the environment containing streptococcus mutans (dental caries pathogenic bacteria), the pH value can be well prevented from being reduced, so that the tooth is prevented from being damaged by the acid environment, and the dental caries is avoided.
Preferably, the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp is as follows: cordyceps militaris extract: and (3) cordyceps militaris fruit body 80-99.9: 0.01 to 20.
When the cordyceps militaris extract and the cordyceps militaris sporocarp are in the weight ratio, the cordyceps militaris extract and the cordyceps militaris sporocarp can fully play respective effects, so that a system contains cordycepin, cordycepic acid, polysaccharide, SOD enzyme and various volatile compounds, thereby achieving the effects of inhibiting bacteria and preventing decayed teeth.
More preferably, the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp is as follows: cordyceps militaris extract: and (3) cordyceps militaris fruit body of 85-92: 8-15.
When the cordyceps militaris extract and the cordyceps militaris sporocarp are in the weight ratio, the toothpaste achieves the best sterilization effect.
Preferably, the preparation raw materials of the dental caries prevention toothpaste also comprise a humectant, an abrasive, a thickening agent and a foaming agent; in the preparation raw materials of the dental caries prevention toothpaste, the humectant accounts for 35-50 wt%, the abrasive accounts for 14-30 wt%, the thickener accounts for 0.5-3 wt%, and the foaming agent accounts for 1.8-3 wt%.
Preferably, the foaming agent is a mixture of sodium lauryl sulfate and at least one of an amino acid surfactant and an amphoteric surfactant.
More preferably, the foaming agent is a mixture of sodium lauryl sarcosinate, sodium lauroyl methyltaurate and cocamidopropyl betaine with sodium lauryl sulfate.
The foaming agent is selected from commercial products, for example, sodium lauroyl sarcosinate can be selected from O L I-4208 of Shanghai Oroli, sodium lauroyl methyltaurate can be selected from O L I-4901 of Shanghai Oroli, cocamidopropyl betaine can be selected from CAPB DC of Galaxy Surfactants and L enotain C30 of Shanghai Li, wherein CAPB DC is particularly suitable.
Preferably, the abrasive is at least one of precipitated silica, ultrafine silica, calcium hydrogen phosphate, and calcium carbonate.
More preferably, the abrasive is a mixture of at least one of precipitated silica, calcium hydrogen phosphate and calcium carbonate and ultrafine silica, wherein the ultrafine silica accounts for 2-6 wt% of the preparation raw materials of the dental caries prevention toothpaste.
The weight percentage of the ultrafine silica in the raw materials for preparing the toothpaste is 2-6%, when the amount of the ultrafine silica is less than 2%, the surface of the paste is not smooth, the tooth brushing taste is poor, when the amount of the ultrafine silica is more than 6%, the paste is easy to harden out water at high temperature, and the stability is affected, the liquid absorption amount of the ultrafine silica is 30-44 ml/20g, preferably 30-38 ml/20g, and commercially available products, such as synthetic silica of the flying snow company, can be used, the liquid absorption amount of the precipitated silica is 15-25 ml/20g, preferably 18-22 ml/20g, precipitated calcite silica of the precipitated silica can be used, such as Zeodent115 of the BER company, the liquid absorption amount of calcium bicarbonate is 5.0-6.5 ml/20g, the apparent density is 0.80-1.00 g/m L, preferably the maximum value, and the apparent density tends to the minimum value, and commercially available products, such as calcium carbonate of the DEBONDA toothpaste, the liquid absorption amount of the calcium carbonate is 3.8.8 g, preferably 0.8.20 g/20 g, and the calcium carbonate powder of the commercially available from the DoPA company can be used.
Preferably, the thickener is at least one of sodium carboxymethylcellulose, carbomer and xanthan gum; the humectant is at least one of sorbitol, glycerol, polyethylene glycol and propylene glycol.
The sodium carboxymethylcellulose can be selected from commercially available products such as TH10 (toothpaste grade) from ASH L AND, with a degree of substitution of 0.75-1.02, preferably 0.95-1.02, AND cellulose with a 2% aqueous viscosity of 600-3000 mPa.s, preferably 1200-2500 mPa.s.Carboxymethylene can be selected from commercially available products such as L ubizol
PO L YMER (toothpaste grade), adjusting pH to about 7 (within the range of 6.5-7.5) with 25% NaOH solution, measuring viscosity with Brookfield RV6 rotor at 20rpm, and neutralizing water solution with viscosity of 0.6% of 15000-40000 mPa.s, preferably 20000-30000 mPa.s. xanthan gum, also called xanthan gum, and commercially available products such as CPKelco
Xanthan Gum (oral grade), 1 thereof% xanthan gum in 1% KCl solution with a viscosity of 1200-1600 mPas measured with Brookfield RV6 rotor at 20 rpm.
The caries preventing toothpaste of the invention can be added or used with other auxiliary materials, such as sweetening agents, pH regulators, spices, coloring agents and the like, in addition to the specific requirements of the components, within the range of not damaging the effect of the invention, and the technicians in the field can select the common content according to the conventional standard.
Preferably, the dental caries prevention toothpaste also comprises the following components in percentage by mass: 0.1-2% of sweetening agent, 0.1-3% of pH regulator and 0.1-2% of spice.
Preferably, the sweetener is at least one of sodium saccharin, sucralose, and stevia; the spice is at least one of menthol, peppermint oil, spearmint oil, wintergreen oil, peppermint, sweet orange oil, lemon oil, anise oil and eucalyptus oil; the pH regulator is at least one of sodium hydroxide, anhydrous trisodium phosphate, sodium tripolyphosphate, alkaline phosphate and sodium dihydrogen phosphate.
The preparation method of the dental caries prevention toothpaste comprises the following steps:
(1) pre-dissolving potassium nitrate and auxiliary materials;
(2) premixing the friction agent and the thickening agent;
(3) adding the humectant and the materials in the step (1) into a paste preparation tank;
(4) opening a vacuum system of the paste making tank, vacuumizing, adding the mixture obtained in the step (2), cordyceps militaris essence, O-cymene-5-ol, potassium nitrate, sodium phytate, zinc citrate and polyvinylpyrrolidone, and stirring and homogenizing under the condition of keeping the vacuum between-0.05 Mpa and-0.085 Mpa;
(5) adding foaming agent into the paste preparation tank, keeping the vacuum between-0.05 Mpa and-0.085 Mpa, and continuously stirring and homogenizing;
(6) degassing a paste preparation tank until the vacuum degree is-0.092 Mpa to-0.098 Mpa, and discharging paste to obtain the toothpaste for preventing dental caries.
The invention has the beneficial effects that: the invention provides a decayed tooth preventing toothpaste, which has remarkable anti-inflammatory and antibacterial effects under the condition that cordyceps militaris essence and various substances with decayed tooth preventing effects are matched for use, has stronger decayed tooth preventing effects, remarkably enhances the anti-inflammatory and antibacterial effects and the decayed tooth preventing effects, comprehensively prevents decayed teeth and strengthens teeth under the synergistic effect of the cordyceps militaris essence and multiple decayed tooth preventing components, and is suitable for sensitive teeth patients to use.
Drawings
FIG. 1 is a comparison graph of the bacteriostasis test of the toothpastes of example 5 and comparative examples 1-6 on staphylococcus aureus;
FIG. 2 is a comparison graph of the bacteriostatic tests of the toothpastes of example 5 and comparative examples 1-6 on Streptococcus mutans;
FIG. 3 is a comparison chart of the bacteriostasis test of the toothpastes of example 5 and comparative examples 1-6 on the porphyromonas gingivalis.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Example 1
One embodiment of the dental caries prevention toothpaste comprises the following preparation raw materials in percentage by weight: 0.1% of cordyceps militaris essence, 0.654% of sodium monofluorophosphate, 0.1% of calcium glycerophosphate, 0.01% of O-cymene-5-alcohol, 3% of potassium nitrate, 0.5% of xylitol, 50% of humectant, 14% of abrasive, 0.5% of thickening agent, 1.8% of foaming agent, 0.1% of sweetening agent, 0.1% of pH regulator, 0.1% of spice and the balance of deionized water;
the cordyceps militaris essence is a mixture of cordyceps militaris extract and cordyceps militaris fruiting body, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris fruiting body is as follows: cordyceps militaris extract: cordyceps militaris fruit body 99.9: 0.01; the humectant is sorbitol; the thickening agent is sodium carboxymethyl cellulose; the foaming agent is a mixture of sodium lauroyl sarcosinate and sodium dodecyl sulfate; the mixture of the abrasive precipitated silica and the superfine silica accounts for 2 percent of the weight of the superfine silica in the preparation raw materials of the anti-caries toothpaste; the sweetener is saccharin sodium; the spice is menthol; the pH regulator is alkaline phosphate and sodium dihydrogen phosphate.
Example 2
One embodiment of the dental caries prevention toothpaste comprises the following preparation raw materials in percentage by weight: 5% of cordyceps militaris essence, 0.62% of stannous fluoride, 0.8% of calcium glycerophosphate, 0.1% of O-cymene-5-alcohol, 10% of potassium nitrate, 10% of xylitol, 35% of humectant, 20% of abrasive, 3% of thickening agent, 3% of foaming agent, 2% of sweetener, 3% of pH regulator, 2% of perfume and the balance of deionized water;
the cordyceps militaris essence is a mixture of cordyceps militaris extract and cordyceps militaris fruiting body, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris fruiting body is as follows: cordyceps militaris extract: cordyceps militaris fruit body 80: 20; the humectant is a mixture of sorbitol and glycerol; the thickening agent is a mixture of sodium carboxymethylcellulose and carbomer; the foaming agent is a mixture of sodium lauroyl methyl taurate and sodium dodecyl sulfate; the abrasive is a mixture of calcium hydrophosphate and superfine silicon dioxide, and the weight percentage of the superfine silicon dioxide in the preparation raw materials of the anti-caries toothpaste is 6%; the sweetener is sucralose; the spice is spearmint oil; the pH regulator is sodium hydroxide.
Example 3
One embodiment of the dental caries prevention toothpaste comprises the following preparation raw materials in percentage by weight: 0.5% of cordyceps militaris essence, 0.33% of sodium fluoride, 0.1% of calcium glycerophosphate, 0.05% of O-cymene-5-ol, 3% of potassium nitrate, 0.5% of erythritol, 40% of humectant, 30% of abrasive, 0.5% of thickening agent, 1.8% of foaming agent, 0.1% of sweetening agent, 0.1% of pH regulator, 0.1% of perfume and the balance of deionized water;
the cordyceps militaris essence is a mixture of cordyceps militaris extract and cordyceps militaris fruiting body, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris fruiting body is as follows: cordyceps militaris extract: cordyceps militaris fruit body 92: 8; the humectant is a mixture of sorbitol and propylene glycol; the thickening agent is a mixture of sodium carboxymethylcellulose and xanthan gum; the foaming agent is a mixture of cocamidopropyl betaine and sodium lauryl sulfate; the abrasive is a mixture of calcium carbonate and superfine silicon dioxide, and the weight percentage of the superfine silicon dioxide in the preparation raw materials of the anti-caries toothpaste is 4%; the sweetener is stevia rebaudiana; the spice is lemon oil; the pH regulator is anhydrous trisodium phosphate.
Example 4
One embodiment of the dental caries prevention toothpaste comprises the following preparation raw materials in percentage by weight: 3% of cordyceps militaris essence, 0.18% of sodium fluoride, 0.5% of calcium glycerophosphate, 0.08% of O-cymene-5-alcohol, 5% of potassium nitrate, 5% of erythritol, 45% of humectant, 20% of abrasive, 2% of thickener, 2% of foaming agent, 1% of sweetener, 2% of pH regulator, 1% of perfume and the balance of deionized water;
the cordyceps militaris essence is a mixture of cordyceps militaris extract and cordyceps militaris fruiting body, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris fruiting body is as follows: cordyceps militaris extract: cordyceps militaris fruit body 85: 15; the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and superfine silica, and the weight percentage of the superfine silica in the preparation raw materials of the anti-caries toothpaste is 6%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Example 5
One embodiment of the dental caries prevention toothpaste comprises the following preparation raw materials in percentage by weight: 2.5% of cordyceps militaris essence, 0.3% of sodium fluoride, 0.3% of calcium glycerophosphate, 0.05% of O-cymene-5-alcohol, 4% of potassium nitrate, 3% of erythritol, 30% of humectant, 22% of abrasive, 2% of thickener, 2% of foaming agent, 1% of sweetener, 2% of pH regulator, 1% of perfume and the balance of deionized water;
the cordyceps militaris essence is a mixture of cordyceps militaris extract and cordyceps militaris fruiting body, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris fruiting body is as follows: cordyceps militaris extract: cordyceps militaris fruit body 90: 10; the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the preparation raw materials of the anti-caries toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Example 6
According to an embodiment of the caries prevention toothpaste, the caries prevention toothpaste is different from the caries prevention toothpaste in the embodiment 5 only in content of cordyceps militaris essence, and the cordyceps militaris essence of the caries prevention toothpaste accounts for 5 wt% of a preparation raw material of the toothpaste.
Example 7
According to an embodiment of the caries prevention toothpaste, the caries prevention toothpaste is different from the caries prevention toothpaste in the embodiment 5 only in content of cordyceps militaris essence, and the cordyceps militaris essence of the caries prevention toothpaste is 4 wt% in the preparation raw materials of the toothpaste.
Example 8
According to an embodiment of the caries prevention toothpaste, the caries prevention toothpaste is different from the caries prevention toothpaste in the embodiment 5 only in content of cordyceps militaris essence, and the cordyceps militaris essence of the caries prevention toothpaste accounts for 2% of the preparation raw materials of the toothpaste in percentage by weight.
Example 9
According to an embodiment of the caries prevention toothpaste, the caries prevention toothpaste is different from the caries prevention toothpaste of embodiment 5 only in content of cordyceps militaris essence, and the cordyceps militaris essence of the caries prevention toothpaste accounts for 1% of the preparation raw materials of the toothpaste.
Example 10
According to an embodiment of the caries prevention toothpaste, the caries prevention toothpaste is different from the caries prevention toothpaste of embodiment 5 only in content of cordyceps militaris essence, and the cordyceps militaris essence of the caries prevention toothpaste is 0.1% by weight of a preparation raw material of the toothpaste.
Example 11
In an embodiment of the toothpaste for preventing dental caries, the preparation raw materials of the toothpaste in the embodiment are different from those of the toothpaste in the embodiment 5 only in the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp is as follows: cordyceps militaris extract: cordyceps militaris fruit body 99.9: 0.01.
example 12
In an embodiment of the toothpaste for preventing dental caries, the preparation raw materials of the toothpaste in the embodiment are different from those of the toothpaste in the embodiment 5 only in the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp is as follows: cordyceps militaris extract: cordyceps militaris fruit body 95: 5.
example 13
In an embodiment of the toothpaste for preventing dental caries, the preparation raw materials of the toothpaste in the embodiment are different from those of the toothpaste in the embodiment 5 only in the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp is as follows: cordyceps militaris extract: cordyceps militaris fruit body 92: 8.
example 14
In an embodiment of the toothpaste for preventing dental caries, the preparation raw materials of the toothpaste in the embodiment are different from those of the toothpaste in the embodiment 5 only in the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp is as follows: cordyceps militaris extract: cordyceps militaris fruit body 85: 15.
example 15
In an embodiment of the toothpaste for preventing dental caries, the preparation raw materials of the toothpaste in the embodiment are different from those of the toothpaste in the embodiment 5 only in the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp is as follows: cordyceps militaris extract: cordyceps militaris fruit body 80: 20.
comparative example 1
The preparation raw materials of the toothpaste of the invention for preventing dental caries are different from those of the toothpaste of the embodiment 5 in that the preparation raw materials of the toothpaste of the invention for the comparison do not contain cordyceps militaris essence, sodium monofluorophosphate, calcium glycerophosphate, O-cymene-5-alcohol and erythritol, namely the toothpaste of the comparison comprises the following preparation raw materials in percentage by weight: 4% of potassium nitrate, 50% of a humectant, 22% of an abrasive, 2% of a thickening agent, 2% of a foaming agent, 1% of a sweetening agent, 2% of a pH regulator, 1% of a perfume and the balance of deionized water;
wherein the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the preparation raw materials of the anti-caries toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Comparative example 2
The preparation raw materials of the toothpaste of the invention for preventing dental caries are different from those of the toothpaste of the embodiment 5 in that the preparation raw materials of the toothpaste of the invention for the comparison do not contain sodium monofluorophosphate, calcium glycerophosphate, O-cymene-5-ol, potassium nitrate and erythritol, namely the toothpaste of the comparison comprises the following preparation raw materials in percentage by weight: 2.5% of cordyceps militaris essence, 4% of potassium nitrate, 50% of humectant, 22% of abrasive, 2% of thickener, 2% of foaming agent, 1% of sweetener, 2% of pH regulator, 1% of perfume and the balance of deionized water;
wherein the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the preparation raw materials of the anti-caries toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Comparative example 3
The preparation raw materials of the toothpaste of the comparative example are different from those of the toothpaste of the example 5 in that the preparation raw materials of the toothpaste of the comparative example do not contain cordyceps militaris essence, calcium glycerophosphate, O-cymene-5-ol and erythritol, namely the toothpaste of the comparative example comprises the following preparation raw materials in percentage by weight: 0.8% of sodium monofluorophosphate, 4% of potassium nitrate, 50% of humectant, 22% of abrasive, 2% of thickening agent, 2% of foaming agent, 1% of sweetening agent, 2% of pH regulator, 1% of perfume and the balance of deionized water;
wherein the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the preparation raw materials of the anti-caries toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Comparative example 4
The preparation raw materials of the toothpaste of the invention for preventing dental caries are different from those of the toothpaste of the embodiment 5 in that the preparation raw materials of the toothpaste of the invention for the comparison do not contain cordyceps militaris essence, sodium monofluorophosphate, O-cymene-5-alcohol and erythritol, namely the toothpaste of the comparison comprises the following preparation raw materials in percentage by weight: 0.3% of calcium glycerophosphate, 4% of potassium nitrate, 50% of humectant, 22% of abrasive, 2% of thickening agent, 2% of foaming agent, 1% of sweetening agent, 2% of pH regulator, 1% of perfume and the balance of deionized water;
wherein the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the preparation raw materials of the anti-caries toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Comparative example 5
The preparation raw materials of the toothpaste of the invention for preventing dental caries are different from those of the toothpaste of the embodiment 5 in that the preparation raw materials of the toothpaste of the invention for the comparison do not contain cordyceps militaris essence, sodium monofluorophosphate, calcium glycerophosphate and erythritol, namely the toothpaste of the comparison comprises the following preparation raw materials in percentage by weight: 0.05% of O-cymene-5-alcohol, 4% of potassium nitrate, 50% of a humectant, 22% of an abrasive, 2% of a thickening agent, 2% of a foaming agent, 1% of a sweetener, 2% of a pH regulator, 1% of a perfume and the balance of deionized water;
wherein the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the preparation raw materials of the anti-caries toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Comparative example 6
The preparation raw materials of the toothpaste of the comparative example are different from those of the toothpaste of the example 5 in that the preparation raw materials of the toothpaste of the comparative example do not contain cordyceps militaris essence, sodium monofluorophosphate, calcium glycerophosphate and O-cymene-5-alcohol, namely the toothpaste of the comparative example comprises the following preparation raw materials in percentage by weight: 4% of potassium nitrate, 3% of erythritol, 50% of a humectant, 22% of an abrasive, 2% of a thickener, 2% of a foaming agent, 1% of a sweetener, 2% of a pH regulator, 1% of a perfume and the balance of deionized water;
wherein the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the preparation raw materials of the anti-caries toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Comparative example 7
The preparation raw materials of the toothpaste of the invention are different from those of the toothpaste of the embodiment 5 only in the content of cordyceps militaris essence, and the content of the cordyceps militaris essence in the preparation raw materials of the toothpaste of the invention is 6% by weight.
Comparative example 8
The invention relates to a comparative example of toothpaste for preventing dental caries, which is prepared from raw materials different from those in example 5 only in the weight ratio of cordyceps militaris extract to cordyceps militaris fruit body, wherein the weight ratio of cordyceps militaris extract to cordyceps militaris fruit body is as follows: cordyceps militaris extract: the ratio of cordyceps militaris fruit body is 100: 0.
Comparative example 9
The invention relates to a comparative example of toothpaste for preventing dental caries, which is prepared from raw materials different from those in example 5 only in the weight ratio of cordyceps militaris extract to cordyceps militaris fruit body, wherein the weight ratio of cordyceps militaris extract to cordyceps militaris fruit body is as follows: cordyceps militaris extract: the ratio of cordyceps militaris fruit body is 75: 25.
Example 16
The toothpaste for preventing dental caries in the embodiments 1-15 and the toothpaste for comparing examples 1-9 are subjected to bacteriostasis tests on several common bacteria in the oral cavity.
The bacteriostasis test method comprises the following steps: the test was carried out by a third party agency according to the test method for resistance (inhibition) of Disinfection Specification 2.1.8.
Preparing the bacteriostatic tablets: preparing bacteriostatic agent raw paste sheets with the diameter of 5mm and the thickness of no more than 4mm in a clean sterile plate, and grouping every 4 sheets (blocks).
Preparation of negative pair photographs: taking a sterile dry filter paper sheet, and dripping sterile distilled water into each sheet for later use.
Inoculation of test bacteria by dipping with sterile cotton swab at 5 × 10 concentration5cfu/ml～5×106The cfu/ml test bacterial suspension is evenly smeared on the surface of a nutrient agar medium flat plate for 3 times, the flat plate should rotate 60 degrees every time the smearing is carried out for 1 time, finally, a cotton swab is smeared for a circle around the edge of the flat plate, the flat plate is covered, and the room temperature is kept for drying for 5 min.
Sticking bacteriostatic agent sample pieces: each test is stuck with 1 infectious bacterium plate, each plate is stuck with 4 test sample plates of the same test group, 1 negative pair photo, and 5 negative pair photos. A sample was taken with sterile forceps and placed on the surface of the plate. The distance between the centers of the various pieces is more than 25mm, and the distance between the centers of the various pieces and the periphery of the flat plate is more than 15 mm. After the adhesive tape is well stuck and placed,
the sample wafer is lightly pressed with sterile forceps to be tightly attached to the surface of the flat plate. The plate is covered, the plate is placed in an incubator at 37 ℃, and the result is observed after the plate is cultured for 16 to 18 hours. The direct measurement of the zone of inhibition was measured with a vernier caliper and recorded, and the test was repeated 3 times.
The strains tested at this time selected common oral pathogens: staphylococcus aureus, streptococcus mutans, and porphyromonas gingivalis.
And (3) bacteriostatic test evaluation standard: if the diameter of the bacteriostatic ring is larger than 7mm, the bacteriostatic ring is judged to have bacteriostatic action; if the diameter of the antibacterial ring is less than or equal to 7mm, the product is judged to have no antibacterial effect. The results of the bacteriostatic tests of the toothpastes in the examples 1 to 10 and the comparative examples 1 to 7 are shown in table 1, the results of the bacteriostatic tests of the toothpastes in the example 5 and the comparative examples 1 to 6 are shown in attached figures 1 to 3, and the results of the bacteriostatic tests of the toothpastes in the examples 5, 11 to 15 and the comparative examples 7 and 8 are shown in table 2.
TABLE 1 results of bacteriostatic tests on toothpastes described in examples 1 to 10 and comparative examples 1 to 7
As can be seen from table 1, the antibacterial effect of the toothpaste for preventing dental caries in examples 1 to 10 is superior to that of the toothpaste in comparative examples 1 to 7, and particularly, as can be seen from comparison of the antibacterial effect of example 5 and comparative examples 1 to 6 in the attached drawings 1 to 3, the antibacterial effect of example 5 is greater than one or more of cordyceps militaris essence, sodium monofluorophosphate, calcium glycerophosphate, O-cymene-5-ol, potassium nitrate and natural sugar alcohol, which indicates that the compounding of cordyceps militaris essence, sodium monofluorophosphate, calcium glycerophosphate, O-cymene-5-ol, potassium nitrate and natural sugar alcohol in a certain proportion range can play a synergistic role. From the bacteriostatic effect comparative examples of examples 5-10 and comparative example 7, it can be seen that the bacteriostatic effect increases with the increase of the addition amount of the cordyceps militaris essence, but the addition amount of comparative example 7 increases by 1% compared with example 6, but the bacteriostatic effect is not increased significantly.
TABLE 2 results of bacteriostatic tests on the toothpastes of examples 5, 11-15 and comparative examples 7, 8
As can be seen from table 2, under the condition of a certain content of the essence of cordyceps militaris, the antibacterial effect of the prepared toothpaste tends to increase and decrease with the increase of the content of the fruiting body of cordyceps militaris, and the weight ratio of the extract of cordyceps militaris to the fruiting body of cordyceps militaris is as follows: cordyceps militaris extract: and (3) cordyceps militaris fruit body of 85-92: the best effect is achieved when the temperature is 8-15 ℃.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (11)
1. A dental caries preventing toothpaste is characterized by comprising cordyceps militaris essence, fluoride, calcium glycerophosphate, O-cymene-5-alcohol, potassium nitrate and natural sugar alcohol; the cordyceps militaris essence is a mixture of cordyceps militaris extract and cordyceps militaris sporocarp; in the preparation raw materials of the anti-caries toothpaste, the cordyceps militaris essence accounts for 0.1-5 wt%, and the cordyceps militaris extract and the cordyceps militaris sporocarp account for the following weight ratios: cordyceps militaris extract: and (3) cordyceps militaris fruit body of 85-92: 8-15.
2. The toothpaste for preventing dental caries according to claim 1, wherein the raw materials for preparing the toothpaste for preventing dental caries comprise 0.1 to 0.8 wt% of calcium glycerophosphate, 0.01 to 0.1 wt% of O-cymene-5-ol, 3 to 10 wt% of potassium nitrate and 0.5 to 10 wt% of natural sugar alcohol.
3. The toothpaste for preventing dental caries as claimed in claim 1, wherein in the raw materials for preparing the toothpaste for preventing dental caries, the cordyceps militaris essence is 0.5-3 wt%, the calcium glycerophosphate is 0.1-0.5 wt%, the O-cymene-5-ol is 0.05-0.08 wt%, the potassium nitrate is 3-5 wt%, and the natural sugar alcohol is 0.5-5 wt%.
4. The toothpaste according to claim 1, wherein the fluoride provides the fluoride ion at a concentration of 850 to 1500mg/kg in the toothpaste.
5. The caries resistant toothpaste of claim 1 wherein said fluoride is at least one of sodium fluoride, sodium monofluorophosphate, and stannous fluoride; the natural sugar alcohol is erythritol and/or xylitol.
6. The caries prevention toothpaste of claim 1 wherein the caries prevention toothpaste is prepared from materials further comprising a humectant, an abrasive, a thickener, and a foaming agent; in the preparation raw materials of the dental caries prevention toothpaste, the humectant accounts for 35-50 wt%, the abrasive accounts for 14-30 wt%, the thickener accounts for 0.5-3 wt%, and the foaming agent accounts for 1.8-3 wt%.
7. The caries prevention toothpaste of claim 6 wherein said foaming agent is a mixture of sodium lauryl sulfate and at least one of an amino acid surfactant and an amphoteric surfactant.
8. The caries prevention toothpaste of claim 6 wherein said foaming agent is a mixture of sodium lauryl sulfate and at least one of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and cocamidopropyl betaine.
9. The caries prevention toothpaste of claim 6 wherein said abrasive is at least one of precipitated silica, ultra fine silica, calcium hydrogen phosphate and calcium carbonate.
10. The toothpaste for preventing dental caries according to claim 6, wherein the abrasive is a mixture of at least one of precipitated silica, calcium hydrogen phosphate and calcium carbonate and ultrafine silica, wherein the raw materials for preparing the toothpaste for preventing dental caries comprise 2-6 wt% of the ultrafine silica.
11. The caries resistant toothpaste of claim 6 wherein said thickening agent is at least one of sodium carboxymethylcellulose, carbomer, and xanthan gum; the humectant is at least one of sorbitol, glycerol, polyethylene glycol and propylene glycol.
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| CN109350556A (en) * | 2018-09-21 | 2019-02-19 | 广州市玖贰零生物科技有限公司 | A kind of anti-caries toothpaste and preparation method thereof |
| CN109481069A (en) * | 2018-12-21 | 2019-03-19 | 南京奇迪康生物科技有限公司 | A kind of method of bleaching tooth based on whitening cleansing gel |
| EP3982913A1 (en) | 2019-06-14 | 2022-04-20 | The Procter & Gamble Company | Leave-on oral care compositions |
| EP3982912A1 (en) | 2019-06-14 | 2022-04-20 | The Procter & Gamble Company | Leave-on oral care compositions |
| EP3982917A1 (en) | 2019-06-14 | 2022-04-20 | The Procter & Gamble Company | Leave-on oral care compositions |
| WO2020248239A1 (en) * | 2019-06-14 | 2020-12-17 | The Procter & Gamble Company | Leave-on oral care compositions |
| CN115844765A (en) * | 2022-11-25 | 2023-03-28 | 重庆医科大学附属口腔医院 | Antibacterial and anti-caries oral care composition and preparation method thereof |
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