CN105832614B - A kind of edible natural children's toothpaste and preparation method - Google Patents
A kind of edible natural children's toothpaste and preparation method Download PDFInfo
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- CN105832614B CN105832614B CN201610322713.9A CN201610322713A CN105832614B CN 105832614 B CN105832614 B CN 105832614B CN 201610322713 A CN201610322713 A CN 201610322713A CN 105832614 B CN105832614 B CN 105832614B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The present invention relates to a kind of edible natural children's toothpaste and preparation methods, percentage, group become composition, rubbing agent, moisturizer, thickener, sweetener, nutritional ingredient, natural essence and the water of grapefruit seed extract and natural soap tree extractive;The effect of raw material of edible toothpaste for children of the present invention is all made of natural material, nontoxic, without side-effects, has cleaning oral cavity, inhibits plaque to produce, pre- anti-caries, healthy gum;During the use of children, even if having swallowed toothpaste, toxic side effect will not be caused.
Description
Technical field
The present invention relates to Pediatric Oral Emergency care product fields, more particularly to a kind of edible natural children's toothpaste and preparation
Method.
Background technology
People has two secondary natural teeths all one's life, can be divided into deciduous teeth and permanent teeth according to eruption time and form.Deciduous teeth normally have 20,
The eruption 6~8 months generally after birth, deciduous teeth whole eruption in 2 years old or so;Permanent teeth is 28-32 shared, generally from 6 years old left side
Right beginning eruption, before this in second deciduous molar rear eruption sixth-year molar (being commonly called as six-year teeth), and meanwhile permanent central incisor eruption, breast
Central incisor starts shedding off.The replacement of deciduous teeth and permanent teeth is generally completed between 6 years old to 12 years old.
After infant's deciduous teeth eruption, the feeding bottle of sweet tea milk or sweet drink be housed since child contains for a long time, especially containing milk
Bottle sleep, it is easy to cause caries.
If preschool children's eating habit is improper, often eats a piece, sweet food or flour and rice, be unfavorable for the self-cleaning work of tooth
With, it is easy to suffer from dental caries.It is within 3~6 years old the peak period that children suffer from dental caries.Variation takes place in the stage dental arch, diastema occurs, is
It grows permanent teeth and prepares, but easily cause food impaction, cause Proximal caries.Simultaneously as people's mouth motion during sleep is few, saliva point
The amount of secreting is low, and the self-cleaning action in oral cavity is poor, is fed again before being slept after brushing teeth and is susceptible to suffer from dental caries and gingivitis.
The maximum oral cavity variation of school-ager is to grow permanent teeth, " six-year teeth " (sixth-year molar) of new eruption, masticatory function
It is most powerful, it is also easiest to that saprodontia occurs.In addition, due to the variation of precocious hormonal readiness and the accumulation of plaque, blueness is few
It is easy in year cause gingivitis, is mainly shown as bleeding gums, gum swelling, oral peculiar smell etc. when brushing teeth and sting hard object.
For the physilogical characteristics of teenager teeth and oral cavity, if not focusing on Pediatric Oral Emergency health, it is more likely that lead to children's mistake
Early there are the mouth diseases such as tooth decay, pain, directly influences children's study, life and whole body health.
Children, which brush teeth, is preferred children special-purpose toothpaste, and should not use adult's toothpaste.Because being grown up dentifrice abrasives hardness
Height, friction are big, are easy to damage children and are in the lower dental surface of calcification degree in growth and development;Essence irritation is strong,
Taste weight, can influence the sense of taste of children, and easily causes child and detest and refuse to brush teeth;Formula components do not have specific aim, certain
Ingredient may destroy the delicate oral cavity ecological environment of children, and the fluorine dosage of most of toothpaste with fluoride is explained relative to children
Aobvious higher, to child's health, there are security risks.
Children on the market are often added to fluoride at present, and mothproof effect is reached such as sodium fluoride or sodium monofluorophosphate
Fruit, but since the function of deglutition of 6 years old or less children is not developed completely, excessive intake fluorine element can lead to den tal fluorosis, even
It will appear fluorosis of bone, seriously affect the health of children.Therefore develop that a free-floride be mothproof, edible natural children's toothpaste is as city
The needs of field.
Patent application publication CN 104306297 disclose it is a kind of using propolis tincture, wild sesame seed extract as primary efficacy at
The children's mothproof toothpaste divided;
103800259 A of patent application publication CN disclose one kind with propolis tincture, wild sesame seed extract, Papain
Enzyme is children's mothproof toothpaste of main active
Patent application publication CN105125417A discloses a free-floride, non-pigment, without saccharin sodium microvesicle edibility youngster
Virgin toothpaste and preparation method thereof, the toothpaste have cleaning oral cavity, pre- anti-caries and enhancing dental calcium using organic active calcium as abrasive material
The effect of matter.
Patent application publication CN101889970A discloses a with Vitwas E, xylitol, pearl powder, breast
Calcium, zinc gluconate and the coefficient not fluorine-containing edible natural child health care toothpaste of calisanin;
Patent application publication CN101889969A discloses a with Vitwas E, xylitol, pearl hydrolysis
The not fluorine-containing edible natural child nutrition toothpaste of liquid, milk calcium, zinc gluconate and the calciferol style of work;
Patent application publication CN105078782A discloses a edible children's alkalescent without saccharin sodium and fluorine and mends
Calcium toothpaste and preparation method thereof.
Grapefruit seed extract (hereinafter referred to as GSE) is the extracted form natural plant extracted from grape fruit seed and pulp
Object is a kind of very potential high-efficiency broad spectrum bacteriostatic compound, in extremely low concentration, you can obtains apparent sterilization effect
Fruit, it can inhibit Gram-negative and gram-positive bacterium, inhibit virus and parasite.As antibacterial material, GSE is most notable
Advantage to be it more safer than the chemical antiseptic of other synthesis.Show GSE pairs in detection in 1980 according to United States Department of Agriculture
Animal does not have toxicity, and the production that gets the Green Light.Heggers et al. experiments have shown that, GSE ties up archaeocyte to human skin cell
There is no toxicity, while there is very high bacteriostatic activity under this dosage conditions.
Patent application publication CN105411923A discloses a kind of natural broad spectrum preservation group extracted containing grapefruit seed
Close object.Mainly contain grapefruit seed extract, a kind of hydroximic acid, a kind of aromatic alcohol and one or more polyalcohols.
Existing children's toothpaste is primarily present following disadvantage:
In order to pursue effect, it is added to the chemical compositions such as fluoride.Due to the function of deglutition ateliosis of children,
Long-time service has a certain impact to children
In order to pursue safety, the chemical active ingredients such as fluoride are not added, using the ingredient of edible natural, but
The effect of product, cannot ensure, cannot get effectively preventing to the oral problem of children, especially saprodontia.
GSE is a kind of natural antibacterial ingredient of wide spectrum, and antibacterial activity is good, but solubility is low.This affects GSE in natural youngster
Application in virgin toothpaste.Although common chemical surfactant in toothpaste, such as laruyl alcohol sodium sulfovinate energy solubilising GSE,
Since the irritation of the surfactant of chemistry is big, there is damage to the mucous membrane of mouth of children, which also limits GSE in edible natural
Application in property children's toothpaste.
Invention content
Based on this, a kind of edible natural children's toothpaste of present invention offer and preparation method can reach both mothproof effects
Safety is without side-effects good edible natural again is used, children are after swallowing.
One aspect of the present invention provides a kind of edible natural children's toothpaste, percentage, and group becomes:
The composition 0.5~5% of grapefruit seed extract and natural soap tree extractive, optimum amount are 1~3%;
Rubbing agent 15~25%;
Moisturizer 50~75%;
Thickener 0.6~0.9%;
Sweetener 0.1~0.3%;
Nutritional ingredient 0.1~1%;
Natural essence 0.5~1%;
Water surplus, total amount 100%.
The composition of grapefruit seed extract of the present invention and natural soap tree extractive, in the composition, grape fruit
The weight ratio of seed extract and natural soap tree extractive is 1:1~1:10, best proportion 1:5.
This technology has invented a kind of compound of GSE/ natural soaps tree extractive by a large amount of scientific research, this is multiple
Closing object, dissolubility is good in water, and antibacterial effect is better than single GSE.
The composition is applied in edible natural children's toothpaste simultaneously, reaches i.e. safe, and has mothproof, prevention oral cavity
The effect of problem.
GSE has the ability of the inhibition bacterium cooperateed with natural soap tree extractive, therefore the composition of the two significantly carries
The antibacterial effect of GSE is risen, the emulsification of another aspect natural soap trees also enhances the dissolubility of GSE, and then GSE's is anti-
Bacterium effect is greatly improved, therefore reduces the additive amount of GSE.
The composition of GSE/ natural soap tree extractives is applied to edible natural by the present invention according to the hobby of children
Children's toothpaste verifies a not fluorine-containing edible natural children's toothpaste.The raw material of this toothpaste is all made of natural
Material, it is nontoxic, it is without side-effects, there is the effect of cleaning oral cavity, the production of inhibition plaque, pre- anti-caries, healthy gum.In children
Use during, even if having swallowed toothpaste, toxic side effect will not be caused.
Grapefruit seed extract in the present invention is the seed by grape fruit, is extracted and is obtained by ethyl alcohol.
Natural soap tree extractive in the present invention is to crush the branch of Quillaia saponaria, is obtained by the method that water carries.
The moisturizer is one or more of sorbierite, glycerine.
The rubbing agent is one or more of silica, calcite in powder, calcium phosphate dibasic dihydrate, calcium carbonate;
The thickener is one or more of sodium carboxymethylcellulose, xanthans, aluminum magnesium silicate, carrageenan.
The nutritional ingredient is vitamin C, vitamin E, oligofructose, zinc gluconate, calcium lactate, calcium glycerophosphate
More than one;
The sweetener is one or more of xylitol, tri-chloro galactose type sugar, steviol glycoside, Sucralose, saccharin sodium;
The water is deionized water.
Another aspect of the present invention provides a kind of preparation method of edible natural children's toothpaste, includes the following steps:
(1) under the conditions of vacuum degree is -0.4MPa~-0.7MPa, sweetener, nutritional ingredient, water and guarantor is added by formula
Humectant is that -0.75MPa~-0.9MPa is stirred 5~10 minutes in vacuum degree;
(2) it keeps vacuum degree in -0.5~-0.7MPa, rubbing agent and thickener is added by formula, is evacuated to -0.96
~-0.10MPa is stirred 10~15 minutes;
(3) by formula addition natural essence, the mixture of grapefruit seed extract and natural soap tree extractive, stirring 1
~5 minutes;It is evacuated to -0.96~-0.10MPa, is stirred 10~15 minutes.
Percentage, the formula are:
The composition 0.5~5% of grapefruit seed extract and natural soap tree extractive, optimum amount are 1~3%;
Rubbing agent 15~25%;
Moisturizer 50~75%;
Thickener 0.6~0.9%;
Sweetener 0.1~0.3%;
Nutritional ingredient 0.1~1%;
Natural essence 0.5~1%;
Water surplus, total amount 100%.
The composition of grapefruit seed extract of the present invention and natural soap tree extractive, in the composition, grape fruit
The weight ratio of seed extract and natural soap tree extractive is 1:10~1:1, best proportion 1:5.
The present invention compared with the existing technology possessed by advantage and advantageous effect:
(1) a kind of edible natural children's toothpaste ensures safety when children use.Children are swallowing without poison
Side effect.
(2) toothpaste of the present invention is added to the mixture of GSE and natural soap tree extractive, and there is the two collaboration to make
With, to the inhibiting effect of bacterium, far superior to single substance, there is good broad-spectrum antimicrobial effect, product have cleaning oral cavity,
The effect of inhibiting plaque generation, pre- anti-caries, healthy gum.
(3) present invention is to improve the bioavilability of GSE, it is proposed that combines GSE with natural soap tree extractive
Object improves the dissolubility of GSE and to the rejection ability of bacterium using natural soap tree extractive.
(4) formulation of tooth-paste simple production process of the present invention is feasible.
Specific implementation mode
In order to make the purpose , technical scheme and advantage of the present invention be clearer, the present invention is carried out below further
It is described in detail.It should be appreciated that described herein, specific examples are only used to explain the present invention, is not intended to limit the present invention.
Embodiment 1:
Containing GSE and natural soap tree extractive composition (1:5) edible natural children toothpaste prescription, such as the following table 1:
GSE extracts in the present embodiment are the seeds by grape fruit, are extracted and are obtained by ethyl alcohol:Grape fruit seed is taken,
After crushing, 80% ethanol water of 10 times of amounts (weight) is added, is impregnated 12 hours under conditions of 60 DEG C, uses filtered through gauze
Afterwards, filtrate chooses to install evaporimeter through 60 DEG C and is evaporated.
Natural soap tree extractive in the present embodiment is to crush the branch of Quillaia saponaria, is obtained by the method that water carries:Take soap
The distilled water of 12 times of amounts (weight) is added in the branch crushed material of tree, is heated to 80 DEG C and is kept for 2 hours, pours out filtrate, after filtering, spray
Mist is dried.
Containing GSE and natural soap tree extractive composition (1:5) edible natural children toothpaste prescription is shown in Table 1, uses
Preparation process it is as follows:
1) powdered rubbing agent, thickener are weighed up by formula, until being stirred evenly in powder material tank for use
2) it weighs up, is mixed evenly in deionized water for use by sweetener, nutritional ingredient and by formula;
3) it by moisturizer, weighs up by formula and is mixed for use in liquid tank;
4) GSE is mixed with natural soap tree extractive, is weighed up by formula, for use;
5) it by essence, is weighed up by formula, for use.
6) vacuum system for opening Manufacturing medicine extract machine, -0.5MPa is evacuated to by vacuum degree;Step 2 and 3 material are sucked, is opened simultaneously
Dynamic blender, into complete step 2 and 3 material after vacuum degree is evacuated to -0.85MPa, pumping is stirred 10 minutes.
7) material in steps for importing 1, and keep vacuum degree in -0.5MPa into complete, is taken out until by the material in step 1
Vacuum stirs 15 minutes to -0.10MPa.
8) mixture for adding natural essence, GSE and natural soap tree extractive, is stirred 3 minutes;Be evacuated to-
0.10MPa stirs 15 minutes, obtains edible natural children's toothpaste.
Using the method for inhibition zone, the effect for evaluating the toothpaste obtained by embodiment 1 is as follows:
1) after taking human mouth saliva 5ml, 4500rpm centrifugation, with medium culture bacterium, them is allowed to simulate in our oral cavities
Bacterial growth take appropriate bacterium solution to be spread evenly across on culture medium after number of bacteria reaches appropriate amount.
2) toothpaste of Example 1 dilutes 2 times, with nothing with without each 3g of ordinary toothpaste of antiseptic with sterile water respectively
Bacterium filter paper dips toothpaste dilution, is then laid on tablet, for comparing ability antibacterial.
3) culture dish is placed in 37 DEG C of constant temperature incubator and is cultivated for 24 hours, in order to simulated true in our oral cavities
Real environment.
4) diameter for observing transparent region around toothpaste illustrates the anti-of the toothpaste with the diameter of transparent region around toothpaste
Bacterium ability, transparent bigger its antibacterial ability of explanation of loop diameter are stronger.
5) experiment measures, and the toothpaste inhibition zone size obtained by embodiment 1 is 7.2mm, and it is preferable anti-to show that toothpaste has
Bacterium effect.
Embodiment 2
Containing GSE and natural soap tree extractive composition (1:1) edible natural children toothpaste prescription is shown in Table 1, utilizes
The method of embodiment 1 is made edible natural toothpaste and measures the inhibition zone size of the toothpaste of embodiment 2 by Bactericidal test
For 8mm, show that toothpaste has good antibacterial effect.
Embodiment 3
Containing GSE and natural soap tree extractive composition (1:10) edible natural children toothpaste prescription is shown in Table 1, utilizes
The method of embodiment 1 is made edible natural toothpaste and measures the inhibition zone size of the toothpaste of embodiment 2 by Bactericidal test
For 9mm, show that toothpaste has good antibacterial effect.
Embodiment 4
The bacteriostatic experiment of GSE and the mixture of natural soap tree extractive.
Using the method for minimum inhibitory concentration, the antibacterial effect of the composition of the invention obtained test as follows.
It is streptococcus mutans and Bacillus acidi lactici to test strain.Both bacteriums are the most important pathogenic bacteria of saprodontia.
From the results, it was seen that GSE is formed by composition with natural soap tree extractive, it is obviously improved the anti-of GSE
On the one hand bacterium effect is since the collaboration bacteriostasis of the two is, on the other hand due to the emulsification of natural soap trees, enhancing
The dissolubility of GSE improves its bioavilability, therefore the bacteriostasis of the two composition has unexpected technology effect
Fruit.
The composition of GSE/ natural soap tree extractives is applied to edible natural by the present invention according to the hobby of children
Children's toothpaste verifies a not fluorine-containing edible natural children's toothpaste.The raw material of this toothpaste is all made of natural
Material, it is nontoxic, it is without side-effects, there is the effect of cleaning oral cavity, the production of inhibition plaque, pre- anti-caries, healthy gum.In children
Use during, even if having swallowed toothpaste, toxic side effect will not be caused.
Claims (7)
1. a kind of edible natural children's toothpaste, which is characterized in that percentage, group become:
The composition 0.5~5% of grapefruit seed extract and natural soap tree extractive;
Rubbing agent 15~25%;
Moisturizer 50~75%;
Thickener 0.6~0.9%;
Sweetener 0.1~0.3%;
Nutritional ingredient 0.1~1%;
Natural essence 0.5~1%;
Water surplus, total amount 100%;
The grapefruit seed extract and grapefruit seed extract in the composition of natural soap tree extractive and natural soap trees
The weight ratio of extract is 1:5.
2. a kind of edible natural children's toothpaste according to claim 1, which is characterized in that the grapefruit seed extract
It is the seed by grape fruit, is extracted and obtained by ethyl alcohol.
3. a kind of edible natural children's toothpaste according to claim 1, which is characterized in that the natural soap trees extraction
Object is to crush the branch of Quillaia saponaria, is obtained by the method that water carries.
4. a kind of edible natural children's toothpaste according to claim 1, which is characterized in that the moisturizer is sorb
One or more of alcohol, glycerine.
5. a kind of edible natural children's toothpaste according to claim 1, which is characterized in that the rubbing agent is titanium dioxide
One or more of silicon, calcite in powder, calcium phosphate dibasic dihydrate, calcium carbonate;
The thickener is one or more of sodium carboxymethylcellulose, xanthans, aluminum magnesium silicate, carrageenan.
6. a kind of edible natural children's toothpaste according to claim 1, which is characterized in that the nutritional ingredient is dimension life
Plain C, vitamin E, oligofructose, zinc gluconate, calcium lactate, calcium glycerophosphate more than one;
The sweetener is one or more of xylitol, tri-chloro galactose type sugar, steviol glycoside, Sucralose, saccharin sodium;
The water is deionized water.
7. a kind of preparation method of edible natural children's toothpaste described in one of claim 1-6, which is characterized in that including with
Lower step:
(1) under the conditions of vacuum degree is -0.4MPa~-0.7MPa, sweetener, nutritional ingredient, water and moisturizer is added by formula,
It is that -0.75MPa~-0.9MPa is stirred 5~10 minutes in vacuum degree;
(2) it keeps vacuum degree in -0.5~-0.7MPa, rubbing agent and thickener is added by formula, it is evacuated to -0.96~-
0.10MPa is stirred 10~15 minutes;
(3) by formula addition natural essence, the mixture of grapefruit seed extract and natural soap tree extractive, 1~5 point is stirred
Clock;It is evacuated to -0.96~-0.10MPa, is stirred 10~15 minutes.
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CN107625662A (en) * | 2017-08-24 | 2018-01-26 | 林福运 | A kind of children's toothpaste |
CN107714611A (en) * | 2017-11-13 | 2018-02-23 | 常州麒通国际贸易有限公司 | A kind of edible toothpaste for children |
CN107998010A (en) * | 2017-11-14 | 2018-05-08 | 名臣健康用品股份有限公司 | A kind of virgin growth toothpaste of benefit |
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KR20070081613A (en) * | 2006-02-13 | 2007-08-17 | 금호덴탈제약 주식회사 | Toothpaste with grapefruit seed extract |
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CN103385805B (en) * | 2013-07-18 | 2016-06-29 | 广州薇美姿实业有限公司 | A kind of benefit is benefit combination children's toothpaste in evening and one benefit children's toothpaste in evening early |
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US6485711B1 (en) * | 2002-03-21 | 2002-11-26 | Michael J. Olmstead | Organic toothpaste containing saponin |
KR20070081613A (en) * | 2006-02-13 | 2007-08-17 | 금호덴탈제약 주식회사 | Toothpaste with grapefruit seed extract |
CN101889970A (en) * | 2009-05-20 | 2010-11-24 | 广州薇美姿个人护理用品有限公司 | Natural floride-free edible transparent health-care toothpaste for children |
CN105078782A (en) * | 2015-08-18 | 2015-11-25 | 福建爱洁丽日化有限公司 | Edible weakly-alkaline calcium supplement toothpaste free of saccharin sodium and fluorine for children and preparation method of toothpaste |
CN105125417A (en) * | 2015-08-18 | 2015-12-09 | 纳诺神蜂(福建)个人护理用品有限公司 | Fluoride-free, non-pigment and saccharin-sodium-free micro-foam type edible children toothpaste and preparation method thereof |
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