CN105997615B - A kind of edible natural liquid gargle for children and preparation method thereof - Google Patents
A kind of edible natural liquid gargle for children and preparation method thereof Download PDFInfo
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- CN105997615B CN105997615B CN201610325382.4A CN201610325382A CN105997615B CN 105997615 B CN105997615 B CN 105997615B CN 201610325382 A CN201610325382 A CN 201610325382A CN 105997615 B CN105997615 B CN 105997615B
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- natural
- children
- gargle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/85—Polyesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention discloses a kind of edible natural liquid gargle for children and preparation method thereof.It is made of moisturizer, sweetener, natural essence, natural solubilizer, grapefruit seed extract, nutritional ingredient and water, the ingredient of the mouthwash not spirituosity, preservative, petroleum resources, it is safe and non-toxic, even if children swallow, also without toxic side effect, inhibit plaque, pre- anti-caries, cleaning oral cavity simultaneously, the effect of healthy gum.
Description
Technical field
The present invention relates to oral care implement field, more particularly to a kind of edible natural liquid gargle for children and its preparation side
Method.
Background technology
The health care basis of tooth will be played from children, and children's odontopathy usually influences children's health, aobvious according to latest data
Show, 8 one-tenth of children are eurodonticus, wherein 7 one-tenth have multinomial mouth disease.Pediatric Oral Emergency disease is so occurred frequently, is parent couple
It is to cause Chinese children oral cavity disease that the shortage of oral health care of children consciousness and children, which do not form good oral health custom,
A disease basic reason occurred frequently.
3~6 years old children often eat a piece, sweet food or flour and rice since eating habit is improper, are unfavorable for the self-cleaning work of tooth
With being the peak period that children suffer from dental caries.The stage is to grow permanent teeth to prepare, and diastema occurs, easily causes food impaction, causes proximal surface
Dental caries.The maximum oral cavity variation of 6-12 Sui children is to grow permanent teeth, and " six-year teeth " (sixth-year molar) of new eruption, masticatory function is most strong
Greatly, it is also easiest to that saprodontia occurs.In addition, due to the variation of precocious hormonal readiness and the accumulation of plaque, teenager is very
It is easy to cause gingivitis, is mainly shown as bleeding gums, gum swelling, oral peculiar smell etc. when brushing teeth and sting hard object.
Chinese children oral health is mainly brushed teeth at present, but is brushed teeth and can only be cleaned 45% or so of oral cavity area, also
Many mouth area such as teeth space, tongue fur, the oral cavity regions Nei Hedeng cannot all be cleaned well.Therefore, children are after after brushing,
Using oral cavity cleaning and nursing liquid, is conducive to further clean oral cavity, reduces oral bacteria, prevent oral problem.
Liquid gargle for children on the market is less at present, it is most of be all be prepared using chemically synthesized raw material, and
It is often added to fluoride, mothproof, but swallowing due to 6 years old or less children is achieved the effect that such as sodium fluoride or sodium monofluorophosphate
Function is not developed completely, and excessive intake fluorine element can lead to den tal fluorosis, or even will appear fluorosis of bone, seriously affect children's
Health.Therefore it is healthy to develop that a free-floride be mothproof, edible natural liquid gargle for children may advantageously facilitate Pediatric Oral Emergency.
Patent application publication CN 103330673A disclose a kind of edible children's mouthwash, it is characterised in that：It
It is to be formed by peppermint, propolis, mango extracting solution, vine polyphenol, sodium chloride, vitamin C and fossil water mixed preparing.
Patent application publication CN 104940052A disclose the present invention and disclose a kind of children special-purpose mouthwash, this is gargled
Water is formed by STEVIA REBAUDIANA, Siraitia grosvenorii, lotus, the mixed preparings such as honeysuckle, sodium chloride.By being carried from each middle medicinal herbs of natural material
Active constituent is taken, and combination collocation uses, there is cleaning, mothproof, hemostasis, whitening work(to make mouthwash obtained not only
Effect, due also to what it used is natural plant material, therefore without containing alcohol, chemicals, to the body of children without wound
Evil.
Grapefruit seed extract (hereinafter referred to as GSE) is the natural plant extracts extracted from grape fruit seed, is a kind of
Very potential high-efficiency broad spectrum bacteriostatic compound, in extremely low concentration, you can obtain apparent bactericidal effect, it can inhibit
Gram-negative and gram-positive bacterium inhibit virus and parasite.As antibacterial material, the most significant advantages of GSE are them
Chemical antiseptic than other synthesis is safer.
Stroke etc. studies antibacterial activity of the grape fruit gargle to Streptococcus mutans, the result shows that grape fruit gargle is to becoming
Different streptococcic MIC is 46.875mg/L, MBC 93.75mg/L.Scanning electron microscopic observation is shown, after the processing of grape fruit gargle
Streptococcus mutans there is cell wall rupture, content overflows.This illustrates variation hammer of the grape fruit gargle in vitro culture
Bacterium has apparent inhibition and killing effect, the integrality that suppression mechanism may destroy cell wall structure with grape fruit extract have
It closes.
Liu Jiandang passes through the research to grapefruit seed extract to Streptococcus mutans and actinobacillus actinomycetem comitans inhibiting effect
Mutans streptococcus is inhibited to stick in smooth glass surface it was found that certain density GSE solution (>=1/128 gargle original liquid concentration) has
Effect.GSE solution has apparent inhibition and killing effect, suppression mechanism may be with it the Aa and mutans streptococcus of in vitro culture
In GSE destroy cell wall structure integrality it is related.Two kinds of gargles of grapefruit seed extract and Cetylpyridinium Chloride are to mutans streptococcus
The function and effect of biomembrane are similar, have lethal effect to the outer layer bacterium of day part biomembrane, but are only capable of influencing early stage (3h)
The deep layer bacteria live of mutans streptococcus biomembrane.
Existing liquid gargle for children is primarily present following disadvantage：
In order to pursue effect, it is added to the chemical syntheses ingredient such as fluoride.Since the function of deglutition of children is developed not
Completely, it is used for a long time and has a certain impact to children
In order to pursue safety, the chemical active ingredients such as fluoride are not added, using the ingredient of edible natural, but
The effect of product, cannot ensure, cannot get effectively preventing to the oral problem of children, especially saprodontia.
GSE is a kind of natural antibacterial ingredient of wide spectrum, and antibacterial activity is good, but solubility is low.Due to edible natural children
Mouthwash does not add chemically synthesized surfactant and alcohol, and the solubilizing effect of formula is weaker, this affects GSE natural
Application in liquid gargle for children.
Invention content
Based on this, a kind of edible natural liquid gargle for children of present invention offer and preparation method thereof, which is free of wine
The ingredient of essence, preservative, petroleum resources, it is safe and non-toxic, even if without toxic side effect if children swallow, while inhibit plaque,
The effect of pre- anti-caries, cleaning oral cavity, healthy gum.
One aspect of the present invention provides a kind of edible natural liquid gargle for children, and the gargle is by moisturizer, sweetener, natural
Essence, natural solubilizer, grapefruit seed extract, nutritional ingredient and water composition；
The weight percent of each ingredient is:Moisturizer 10~30%, sweetener 0.05~0.3%, natural essence 0.1~
0.5%, natural solubilizer 0.5~3%, grapefruit seed extract 0.1~1.0%, nutritional ingredient 0.1~1%, water surplus, always
Amount is 100%.
Further, the moisturizer is one or more of sorbierite, glycerine.
Further, the sweetener is one in Sucralose, xylitol, tri-chloro galactose type sugar, steviol glycoside, saccharin sodium
Kind or more.
Further, the nutritional ingredient is vitamin C, vitamin C phosphoric ester, vitamin E, oligofructose, glucose
One or more of sour zinc, calcium lactate, calcium glycerophosphate.
Further, the natural essence is one or more of Mint Essence, orange flavor, strawberry essence；
Further, the natural solubilizer mixed by both natural soap tree extractive and -2 stearate of polyglycereol and
At the weight ratio of the two is 2:1~4:1.
The water is deionized water.
Another aspect of the present invention provides a kind of preparation method of edible natural liquid gargle for children, includes the following steps：
(1) natural solubilizer is dissolved in the water of part according to formula, under stirring condition, grapefruit seed extract and perfume is added
Essence, adds moisturizer, and stirring obtains aqueous solution in 5~10 minutes；
(2) sweetener and nutritional ingredient are dissolved in remaining water according to formula, stir evenly, is added to step (1) and obtains
In the aqueous solution obtained, stir 10~20 minutes；
The formula is:Moisturizer 10~30%, sweetener 0.05~0.3%, natural essence 0.1~0.5%, natural increasing
Solvent 0.5~3%, grapefruit seed extract 0.1~1.0%, nutritional ingredient 0.1~1%, water surplus, total amount 100%, with
Weight percent meter.
The present invention compared with the existing technology possessed by advantage and advantageous effect.
(1) the component Nantural non-toxic of gargle of the present invention ensures that safety when children use, children do not have swallowing yet
Toxic side effect.
(2) present invention is to improve the bioavilability of GSE, it is proposed that by -2 stearate of polyglycereol and natural soap trees group
At composition, the dissolubility of GSE is improved, to improve the bioactivity of GSE；On the other hand, natural soap trees send out with GSE
Synergistic effect is waved so that bacteriostasis property is greatly improved, to inhibit plaque, pre- anti-caries, cleaning mouth well
Chamber.
(3) formulation of tooth-paste simple production process of the present invention is feasible.
Specific implementation mode
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
Edible natural liquid gargle for children formula such as table 1 containing GSE：
GSE extracts in the present embodiment are the seeds by grape fruit, are extracted and are obtained by ethyl alcohol:Grape fruit seed is taken,
After crushing, the ethanol water of 80% (v/v) of 10 times of amounts (weight) is added, is impregnated 12 hours under conditions of 60 DEG C, uses yarn
Cloth filtering after, filtrate through 60 DEG C choose to install evaporimeter be evaporated to get).
Natural soap tree extractive in the present embodiment is to crush the branch of Quillaia saponaria, is obtained by the method that water carries:Take soap
The distilled water of 12 times of amounts (weight) is added in the branch crushed material of tree, is heated to 80 DEG C and is kept for 2 hours, pours out filtrate, after filtering, spray
Mist is drying to obtain).
Embodiment 1
The preparation method of gargle, it is such as following.
1) it is formulated according to table 1 and natural solubilizer is dissolved in the water of 50% (the 50% of the amount of water in formula), stirring condition
Under, grapefruit seed extract and essence is added, stirs evenly for use
2) sweetener, nutritional ingredient are weighed up by formula, is mixed evenly in remaining deionized water for use；
3) moisturizer is added in step 1 by formula, is stirred 10 minutes.
4) step (2) is added by the aqueous solution of sweetener and nutritional ingredient, is stirred 20 minutes, you can
Using the method for inhibition zone, the inhibition zone size for measuring the mouthwash obtained by embodiment 1 is 7.5mm, shows to produce
Product have preferable bactericidal effect.
Embodiment 2
The preparation method of gargle, it is such as following.
1) it is formulated according to table 1 and natural solubilizer is dissolved in 50% formula water, under stirring condition, grapefruit seed is added and carries
Object and essence are taken, is stirred evenly for use
2) sweetener, nutritional ingredient are weighed up by formula, is mixed evenly in remaining deionized water for use；
3) moisturizer is added in step 1 by formula, is stirred 10 minutes.
4) step (2) is added by the aqueous solution of sweetener and nutritional ingredient, is stirred 20 minutes, you can
Using the method for inhibition zone, the inhibition zone size for measuring the mouthwash obtained by embodiment 1 is 9.2mm, shows to produce
Product have good bactericidal effect.
Embodiment 3
The preparation method of gargle, it is such as following.
1) it is formulated according to table 1 and natural solubilizer is dissolved in 50% formula water, under stirring condition, grapefruit seed is added and carries
Object and essence are taken, is stirred evenly for use
2) sweetener, nutritional ingredient are weighed up by formula, is mixed evenly in remaining deionized water for use；
3) moisturizer is added in step 1 by formula, is stirred 10 minutes.
4) step (2) is added by the aqueous solution of sweetener and nutritional ingredient, is stirred 20 minutes, you can
Using the method for inhibition zone, the inhibition zone size for measuring the mouthwash obtained by embodiment 1 is 10.5mm, shows to produce
Product have good bactericidal effect.
Embodiment 4
The bacteriostatic experiment of GSE and the mixture of natural soap tree extractive.
Using the method for inhibition zone, the antibacterial effect of the composition of the invention obtained test as follows.Test bacterium
Kind is streptococcus mutans and Bacillus acidi lactici.Both bacteriums are the most important pathogenic bacteria of saprodontia.
From the results, it was seen that GSE is formed by composition with natural soap tree extractive, it is obviously improved the anti-of GSE
On the one hand bacterium effect is since the collaboration bacteriostasis of the two is enhanced on the other hand due to the emulsification of natural soap trees
The dissolubility of GSE improves its bioavilability, therefore the two composition has unexpected technology effect in terms of biocidal property
Fruit.
Embodiment 5
GSE and natural soap tree extractive, the bacteriostatic experiment of the mixture of -2 stearate of polyglycereol.
Using the method for inhibition zone, the antibacterial effect of the composition of the invention obtained test as follows.Test bacterium
Kind is streptococcus mutans and Bacillus acidi lactici.Both bacteriums are the most important pathogenic bacteria of saprodontia.
From the results, it was seen that the natural solubilizer of natural soap tree extractive and -2 stearate of polyglycereol composition, shows
The antibacterial effect for improving GSE is write, is on the one hand the collaboration bacteriostasis due to three, on the other hand due to natural solubilizer
Emulsification enhances the dissolubility of GSE, improves its bioavilability, therefore achieves in terms of biocidal property unexpected
Technique effect, especially to the bacteriostasis property of Bacillus acidi lactici.
Several embodiments of the invention above described embodiment only expresses, should not be understood as to the scope of the claims of the present invention
Limitation.It should be pointed out that for those of ordinary skill in the art, without departing from the inventive concept of the premise,
Various modifications and improvements can be made, these are all within the scope of protection of the present invention.Therefore, the protection domain of patent of the present invention
It should be determined by the appended claims.
Claims (6)
1. a kind of edible natural liquid gargle for children, which is characterized in that by moisturizer, sweetener, natural essence, natural solubilising
Agent, grapefruit seed extract, nutritional ingredient and water composition；The weight percent of each ingredient is:
The natural solubilizer is made of both natural soap tree extractive and -2 stearate of polyglycereol, and the weight ratio of the two is
2:1~4:1.
2. a kind of edible natural liquid gargle for children according to claim 1, which is characterized in that the moisturizer is sorb
One or more of alcohol, glycerine.
3. a kind of edible natural liquid gargle for children according to claim 1, which is characterized in that the sweetener is trichlorine
One or more of sucrose, xylitol, tri-chloro galactose type sugar, steviol glycoside, saccharin sodium.
4. a kind of edible natural liquid gargle for children according to claim 1, which is characterized in that the nutritional ingredient is dimension
One kind in raw element C, vitamin C phosphoric ester, vitamin E, oligofructose, zinc gluconate, calcium lactate, calcium glycerophosphate with
On.
5. a kind of edible natural liquid gargle for children according to claim 1, which is characterized in that the natural essence is thin
One or more of lotus essence, orange flavor, strawberry essence；The water is deionized water.
6. a kind of preparation method of edible natural liquid gargle for children described in one of claim 1-5, includes the following steps：
(1) natural solubilizer is dissolved in the water of part according to formula, under stirring condition, grapefruit seed extract and essence is added,
Moisturizer is added, stirring obtains aqueous solution in 5~10 minutes；
(2) sweetener and nutritional ingredient are dissolved in remaining water according to formula, are stirred evenly, be added to step (1) acquisition
In aqueous solution, stir 10~20 minutes.
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106821950A (en) * | 2017-01-23 | 2017-06-13 | 衡阳美娇七商贸有限公司 | The oral care composition and its application of a kind of antibacterial and whitening |
| CN106580836B (en) * | 2017-01-24 | 2019-06-25 | 广州薇美姿实业有限公司 | A kind of oral care composition and its application containing plant factor |
| CN106691944B (en) * | 2017-01-25 | 2018-02-23 | 江苏诺兴生物科技有限公司 | A kind of antibacterial antiviral composition and its application |
| CN108743473A (en) * | 2018-06-28 | 2018-11-06 | 吉林省登泰克牙科材料有限公司 | A kind of mouthrinse composition, preparation method and application |
| CN111265580A (en) * | 2020-03-17 | 2020-06-12 | 浙江亲水园生物科技有限公司 | Composition containing grapefruit seed extract, preparation method and application thereof |
| CN111603418A (en) * | 2020-04-23 | 2020-09-01 | 广州宏康医药科技有限公司 | Oral care product capable of lasting freshness and bacteriostasis and preparation method thereof |
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| CN101416926A (en) * | 2008-11-21 | 2009-04-29 | 福建福泽医药器械科技有限公司 | Grapefruit mouth spraying agent and preparation method thereof |
| CN102512345A (en) * | 2011-12-28 | 2012-06-27 | 美晨集团股份有限公司 | Natural antibacterial gargle and preparation method thereof |
| CN103330673A (en) * | 2013-07-09 | 2013-10-02 | 孙佳丽 | Edible mouthwash for childeren |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030133883A1 (en) * | 2001-06-14 | 2003-07-17 | Finnegan Mary Beth | Oral care compositions containing grapefruit seed extract |
| CN101181208B (en) * | 2007-11-20 | 2010-06-09 | 美晨集团股份有限公司 | Gargle containing natural antibiotics and preparation method thereof |
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2016
- 2016-05-16 CN CN201610325382.4A patent/CN105997615B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101416926A (en) * | 2008-11-21 | 2009-04-29 | 福建福泽医药器械科技有限公司 | Grapefruit mouth spraying agent and preparation method thereof |
| CN102512345A (en) * | 2011-12-28 | 2012-06-27 | 美晨集团股份有限公司 | Natural antibacterial gargle and preparation method thereof |
| CN103330673A (en) * | 2013-07-09 | 2013-10-02 | 孙佳丽 | Edible mouthwash for childeren |
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