CN105997615A - Natural and edible children's mouthwash and preparation method thereof - Google Patents
Natural and edible children's mouthwash and preparation method thereof Download PDFInfo
- Publication number
- CN105997615A CN105997615A CN201610325382.4A CN201610325382A CN105997615A CN 105997615 A CN105997615 A CN 105997615A CN 201610325382 A CN201610325382 A CN 201610325382A CN 105997615 A CN105997615 A CN 105997615A
- Authority
- CN
- China
- Prior art keywords
- natural
- children
- agent
- edible
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/85—Polyesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention discloses natural and edible children's mouthwash and a preparation method thereof. The natural and edible children's mouthwash comprises a moisturizer, a sweetening agent, natural essence, a natural solubilizing agent, a grapefruit seed extract, nutritional ingredients and water. The mouthwash does not contain alcohol, a preservative or ingredients made from petroleum, is safe and non-toxic, does not have toxic or side effects even if the mouthwash is eaten by a child and has the efficacy of inhibiting dental plaque, preventing dental decay, cleaning the oral cavity and keeping gingivae healthy.
Description
Technical field
The present invention relates to oral care implement field, particularly to a kind of edible natural liquid gargle for children and system thereof
Preparation Method.
Background technology
The health care basis of tooth to be played from child, and child's odontopathy usually affects children's health, according to latest data
Display, the child having 8 one-tenth is eurodonticus, and wherein 7 one-tenth have multinomial oral disease.Pediatric Oral Emergency disease is such as
This is occurred frequently, is father and mother's shortage of realizing oral health care of children and child does not form good oral cavity health
Custom is the basic reason causing Chinese children oral disease occurred frequently.
3～6 years old child, owing to dietary habit is improper, often eat a piece, sweet food or flour and rice, be unfavorable for tooth
Self-cleaning action, is the child peak period of suffering from dental caries.This stage prepares for growing permanent teeth, and diastema occurs, easily causes
Food impaction, causes Proximal caries.6-12 year the maximum oral cavity change of child be to grow permanent teeth, " six ages of new eruption
Tooth " (sixth-year molar), its masticatory function is the most powerful, is also easiest to dental caries.Further, since the youth
The change of phase sex hormone level, and the accumulation of dental plaque, teenager is easy to cause gingivitis, main table
Gingival hemorrhage, swelling and aching of gum, halitosis etc. time now for brushing teeth and stinging hard thing.
Chinese children oral cavity health is mainly brushed teeth at present, but brushes teeth and can only clean about the 45% of oral cavity area,
A lot of mouth area such as teeth space, tongue fur, Nei Hedeng region, oral cavity is also had all to can not get well cleaning.Therefore,
Child, after after brushing, uses oral cavity cleaning and nursing liquid, is conducive to cleaning oral cavity, minimizing oral cavity further thin
Bacterium, prevents oral problem.
Liquid gargle for children the most on the market is less, and major part is all that the raw material using chemosynthesis is prepared from,
And often with the addition of fluoride, as sodium fluoride or sodium monofluorophosphate reach mothproof effect, but due to 6
Year, the function of deglutition of following child was not grown completely, and the absorption fluorine element of excess can cause dental fluorosis, even
There will be skeletal fluorosis, have a strong impact on the health of child.Therefore develop that a free-floride is mothproof, edible natural
It is healthy that virgin collutory may advantageously facilitate Pediatric Oral Emergency..
Public announcement of a patent application CN 103330673A discloses a kind of edible child's collutory, its feature
It is: it is by Herba Menthae, propolis, Fructus Mangifera Indicae extracting solution, grape polyphenols, sodium chloride, vitamin C and mineral
Water mixed preparing forms.
Public announcement of a patent application CN 104940052A discloses the open a kind of children special-purpose collutory of the present invention,
This collutory is formed by Folium Stevlae Rebaudianae, Fructus Momordicae, Flos Nelumbinis, the mixed preparing such as Flos Lonicerae, sodium chloride.By from
The each middle medicinal herbs of natural material are extracted active component, and combination collocation uses, so that the collutory prepared is not
Only there is cleaning, mothproof, hemostasis, whitening effect, due also to what it used is all natural plant material,
Therefore ethanol, chemicals are not contained, the health fanout free region to child.
Grapefruit seed extract (hereinafter referred to as GSE) is the natural plant extracts extracted from grapefruit seed,
It is one the most potential high-efficiency broad spectrum bacteriostatic compound, when extremely low concentration, can obtain significantly
Bactericidal effect, it can suppress Gram-negative and gram-positive bacterium, suppression virus and parasite.As
Antibiotic substance, GSE significant advantage is that it is more safer than other chemical antibacterial synthesized.
The research grapefruit collutory antibacterial activity to Streptococcus mutans such as stroke, result shows grapefruit collutory
To the MIC of Streptococcus mutans be 46.875mg/L, MBC be 93.75mg/L.Scanning electron microscopic observation shows,
There is cell wall rupture in Streptococcus mutans after grapefruit collutory processes, and content overflows.This illustrates grapefruit
Collutory has significantly suppression and killing action to the Streptococcus mutans of In vitro culture, and its suppression mechanism may be with Portugal
The integrity that grape Fructus Citri grandis extract destroys cell wall structure is relevant.
Liu Jiandang by grapefruit seed extract to Streptococcus mutans and actinobacillus actinomycetem comitans inhibitory action
Research finds, certain density GSE solution (>=1/128 collutory original liquid concentration) has suppression mutans streptococcus at light
The effect that sliding glass surface sticks.The Aa of In vitro culture and mutans streptococcus are had and significantly suppress and kill by GSE solution
The effect of going out, the integrity that its suppression mechanism may destroy cell wall structure with GSE therein is relevant.Grapefruit seed
Extract and cetylpyridinium chloride two kinds of collutory action effect biomembranous to mutans streptococcus is similar, all biological to day part
The outer layer antibacterial of film has lethal effect, but is only capable of impact (3h) mutans streptococcus biomembranous deep layer bacteria live in early days.
Existing liquid gargle for children, is primarily present following shortcoming:
In order to pursue effect, with the addition of the chemosynthesis compositions such as fluoride.Function of deglutition due to child
Ateliosis, child is had a certain impact by life-time service
In order to pursue safety, without chemical active ingredients such as fluorides, use edible natural
Composition, but effect of product can not get ensureing, and the oral problem to child, particularly dental caries can not get effectively
Preventing and treating.
GSE is the natural antibacterial ingredient of a kind of wide spectrum, and antibacterial activity is good, but dissolubility is low.Due to natural can
Feeding habits child's collutory is without the surfactant of chemosynthesis and ethanol, and the solubilizing effect of its formula is more weak,
This have impact on GSE application in natural liquid gargle for children.
Summary of the invention
Based on this, the present invention provides a kind of edible natural liquid gargle for children and preparation method thereof, this collutory
The not composition of spirituosity, preservative, petroleum resources, safety non-toxic, even if child swallows, does not has poison secondary yet
Effect, suppresses dental plaque, pre-anti-caries, cleaning oral cavity, effect of healthy gingiva simultaneously.
One aspect of the present invention provides a kind of edible natural liquid gargle for children, and this collutory is by wetting agent, sweet taste
Agent, natural essence, natural solubilizing agent, grapefruit seed extract, nutritional labeling and water composition；
The percentage by weight of each composition is: wetting agent 10～30%, sweeting agent 0.05～0.3%, natural
Essence 0.1～0.5%, natural solubilizing agent 0.5～3%, grapefruit seed extract 0.1～1.0%, nutrition
Composition 0.1～1%, water surplus, total amount is 100%.
Further, more than one during described wetting agent is sorbitol, glycerol.
Further, described sweeting agent is sucralose, xylitol, tri-chloro galactose type sugar, stevioside, sugar
Essence sodium in more than one.
Further, described nutritional labeling is vitamin C, vitamin C phosphoric ester, vitamin E, oligomeric
More than one in fructose, zinc gluconate, calcium lactate, calcium glycerophosphate.
Further, more than one during described natural essence is Herba Menthae, Fructus Citri sinensis, Fructus Fragariae Ananssae；
Further, described natural solubilizing agent is by natural soap tree extractive and polyglycereol-2 stearate
Mixing, both weight ratios are 2:1～4:1.
Described water is deionized water.
Another aspect of the present invention provides the preparation method of a kind of edible natural liquid gargle for children, including following step
Rapid:
(1) according to formula, natural solubilizing agent is dissolved in part water, under stirring condition, adds grapefruit seed and carry
Take thing and essence, add wetting agent, stir and obtain aqueous solution in 5～10 minutes；
(2) according to formula, sweeting agent and nutritional labeling are dissolved in remaining water, stir, join step
Suddenly, in the aqueous solution that (1) obtains, stir 10～20 minutes；
Described formula is: wetting agent 10～30%, sweeting agent 0.05～0.3%, natural essence 0.1～
0.5%, natural solubilizing agent 0.5～3%, grapefruit seed extract 0.1～1.0%, nutritional labeling 0.1～
1%, water surplus, total amount is 100%, by weight percentage.
The present invention is relative to prior art have the advantage that and beneficial effect.
(1) the component Nantural non-toxic of collutory of the present invention, it is ensured that safety when child uses, though child
Swallow and also there is no toxic and side effects.
(2) present invention is to improve the bioavailability of GSE, it is proposed that by polyglycereol-2 stearate and sky
So Quillaia saponaria wood is grouped compound, improves the dissolubility of GSE, thus improves the biological activity of GSE；Separately
On the one hand, natural soap trees and GSE have played synergism so that bacteriostasis property is greatly improved,
Thus well suppress dental plaque, pre-anti-caries, cleaning oral cavity.
(3) the formulation of tooth-paste production technology simple possible that the present invention relates to.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment,
The present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to
Explain the present invention, be not intended to limit the present invention.
Edible natural liquid gargle for children formula such as table 1 containing GSE:
GSE extract in the present embodiment is by the seed of grapefruit, is obtained by ethanol extraction: take grapefruit
Seed, after pulverizing, adds the ethanol water of 80% (v/v) of 10 times amount (weight), at 60 DEG C
Under the conditions of soak 12 hours, after filtered through gauze, filtrate chooses to install evaporimeter through 60 DEG C and is evaporated, and to obtain final product).
Natural soap tree extractive in the present embodiment is to be pulverized by the branch of Quillaia saponaria, and the method carried by water is obtained:
Take the branch ground product of Quillaia saponaria, add the distilled water of 12 times amount (weight), be heated to 80 DEG C and keep 2 hours,
Pour out filtrate, after filtration, be spray-dried and get final product).
Embodiment 1
The preparation method of collutory, as following.
1) according to table 1 formula, natural solubilizing agent is dissolved in the water of 50% (in formula the 50% of the amount of water),
Under stirring condition, add grapefruit seed extract and essence, stir stand-by
2) sweeting agent, nutritional labeling being weighed up by formula, in remaining deionized water, mixing and stirring is treated
With；
3) by formula, wetting agent is joined in step 1, stir 10 minutes.
4) add step (2) by the aqueous solution of sweeting agent Yu nutritional labeling, stir 20 minutes.
The method using inhibition zone, the inhibition zone size recording the collutory obtained by embodiment 1 is 7.5mm,
Show that product has preferable bactericidal effect.
Embodiment 2
The preparation method of collutory, as following.
1) according to table 1 formula, natural solubilizing agent is dissolved in the formula water of 50%, under stirring condition, adds Portugal
Grape Fructus Citri grandis seed extract and essence, stir stand-by
2) sweeting agent, nutritional labeling being weighed up by formula, in remaining deionized water, mixing and stirring is treated
With；
3) by formula, wetting agent is joined in step 1, stir 10 minutes.
4) add step (2) by the aqueous solution of sweeting agent Yu nutritional labeling, stir 20 minutes.
The method using inhibition zone, the inhibition zone size recording the collutory obtained by embodiment 1 is 9.2mm,
Show that product has good bactericidal effect.
Embodiment 3
The preparation method of collutory, as following.
1) according to table 1 formula, natural solubilizing agent is dissolved in the formula water of 50%, under stirring condition, adds Portugal
Grape Fructus Citri grandis seed extract and essence, stir stand-by
2) sweeting agent, nutritional labeling being weighed up by formula, in remaining deionized water, mixing and stirring is treated
With；
3) by formula, wetting agent is joined in step 1, stir 10 minutes.
4) add step (2) by the aqueous solution of sweeting agent Yu nutritional labeling, stir 20 minutes.
The method using inhibition zone, the inhibition zone size recording the collutory obtained by embodiment 1 is 10.5mm,
Show that product has good bactericidal effect.
Embodiment 4
The bacteriostatic experiment of the mixture of GSE and natural soap tree extractive.
The method using inhibition zone, it is as follows that the antibacterial effect of the compositions being obtained the present invention carries out test.
Test strain is Streptococcus mutans and lactobacillus.Both antibacterials are the topmost pathogenic bacterium of dental caries.
From the results, it was seen that the compositions that GSE and natural soap tree extractive are formed, it is obviously improved
The antibacterial effect of GSE, is on the one hand the collaborative bacteriostasis due to both, on the other hand due to natural Quillaia saponaria
The emulsification of wood, enhances the dissolubility of GSE, improves its bioavailability, therefore the two compositions
Unforeseeable technique effect is had in terms of biocidal property.
Embodiment 5
GSE and natural soap tree extractive, the bacteriostatic experiment of the mixture of polyglycereol-2 stearate.
The method using inhibition zone, it is as follows that the antibacterial effect of the compositions being obtained the present invention carries out test.
Test strain is Streptococcus mutans and lactobacillus.Both antibacterials are the topmost pathogenic bacterium of dental caries.
From the results, it was seen that natural soap tree extractive and the natural solubilising of polyglycereol-2 stearate composition
Agent, has been obviously improved the antibacterial effect of GSE, is on the one hand the collaborative bacteriostasis due to three, the opposing party
Face, due to the emulsification of natural solubilizing agent, enhances the dissolubility of GSE, improves its bioavailability,
Therefore in terms of biocidal property, achieve unforeseeable technique effect, the especially bacteriostasis property to lactobacillus.
Embodiment described above only have expressed the several embodiments of the present invention, it is impossible to is interpreted as the present invention special
The restriction of profit scope.It should be pointed out that, for the person of ordinary skill of the art, without departing from this
On the premise of inventive concept, it is also possible to make some deformation and improvement, these broadly fall into the protection model of the present invention
Enclose.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. an edible natural liquid gargle for children, it is characterised in that be made up of wetting agent, sweeting agent, natural essence, natural solubilizing agent, grapefruit seed extract, nutritional labeling and water；The percentage by weight of each composition is:
A kind of edible natural liquid gargle for children the most according to claim 1, it is characterised in that described natural solubilizing agent is made up of with polyglycereol-2 stearate natural soap tree extractive, and both weight ratios are 2:1～4:1.
A kind of edible natural liquid gargle for children the most according to claim 1, it is characterised in that described wetting agent is more than one in sorbitol, glycerol.
A kind of edible natural liquid gargle for children the most according to claim 1, it is characterised in that described sweeting agent is more than one in sucralose, xylitol, tri-chloro galactose type sugar, stevioside, saccharin sodium.
A kind of edible natural liquid gargle for children the most according to claim 1, it is characterised in that described nutritional labeling is more than one in vitamin C, vitamin C phosphoric ester, vitamin E, oligofructose, zinc gluconate, calcium lactate, calcium glycerophosphate.
A kind of edible natural liquid gargle for children the most according to claim 1, it is characterised in that described natural essence is more than one in Herba Menthae, Fructus Citri sinensis, Fructus Fragariae Ananssae；Described water is deionized water.
7. the preparation method of a kind of edible natural liquid gargle for children that one of claim 1-6 is described, comprises the following steps:
(1) according to formula, natural solubilizing agent is dissolved in part water, under stirring condition, adds grapefruit seed extract and essence, add wetting agent, stir and obtain aqueous solution in 5～10 minutes；
(2) according to formula, sweeting agent and nutritional labeling are dissolved in remaining water, stir, join in the aqueous solution that step (1) obtains, stir 10～20 minutes.
Preparation method the most according to claim 7, it is characterized in that, described formula is: wetting agent 10～30%, sweeting agent 0.05～0.3%, natural essence 0.1～0.5%, natural solubilizing agent 0.5～3%, grapefruit seed extract 0.1-1.0%, nutritional labeling 0.1～1%, water surplus, total amount is 100%, by weight percentage.
Preparation method the most according to claim 8, it is characterised in that described natural solubilizing agent is made up of with polyglycereol-2 stearate natural soap tree extractive.
Preparation method the most according to claim 9, it is characterised in that described natural soap tree extractive is 2:1～4:1 with the weight ratio of polyglycereol-2 stearate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610325382.4A CN105997615B (en) | 2016-05-16 | 2016-05-16 | A kind of edible natural liquid gargle for children and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610325382.4A CN105997615B (en) | 2016-05-16 | 2016-05-16 | A kind of edible natural liquid gargle for children and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105997615A true CN105997615A (en) | 2016-10-12 |
| CN105997615B CN105997615B (en) | 2018-10-30 |
Family
ID=57098130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610325382.4A Active CN105997615B (en) | 2016-05-16 | 2016-05-16 | A kind of edible natural liquid gargle for children and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105997615B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106580836A (en) * | 2017-01-24 | 2017-04-26 | 广州薇美姿实业有限公司 | Oral care composition containing plant factor and application thereof |
| CN106691944A (en) * | 2017-01-25 | 2017-05-24 | 江苏诺兴生物科技有限公司 | Antibacterial and antiviral composition and application thereof |
| CN106821950A (en) * | 2017-01-23 | 2017-06-13 | 衡阳美娇七商贸有限公司 | The oral care composition and its application of a kind of antibacterial and whitening |
| CN108743473A (en) * | 2018-06-28 | 2018-11-06 | 吉林省登泰克牙科材料有限公司 | A kind of mouthrinse composition, preparation method and application |
| CN111265580A (en) * | 2020-03-17 | 2020-06-12 | 浙江亲水园生物科技有限公司 | Composition containing grapefruit seed extract, preparation method and application thereof |
| CN111603418A (en) * | 2020-04-23 | 2020-09-01 | 广州宏康医药科技有限公司 | Oral care product capable of lasting freshness and bacteriostasis and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030133883A1 (en) * | 2001-06-14 | 2003-07-17 | Finnegan Mary Beth | Oral care compositions containing grapefruit seed extract |
| CN101181208A (en) * | 2007-11-20 | 2008-05-21 | 美晨集团股份有限公司 | Gargle containing natural antibiotics and preparation method thereof |
| CN101416926A (en) * | 2008-11-21 | 2009-04-29 | 福建福泽医药器械科技有限公司 | Grapefruit mouth spraying agent and preparation method thereof |
| CN102512345A (en) * | 2011-12-28 | 2012-06-27 | 美晨集团股份有限公司 | Natural antibacterial gargle and preparation method thereof |
| CN103330673A (en) * | 2013-07-09 | 2013-10-02 | 孙佳丽 | Edible mouthwash for childeren |
-
2016
- 2016-05-16 CN CN201610325382.4A patent/CN105997615B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030133883A1 (en) * | 2001-06-14 | 2003-07-17 | Finnegan Mary Beth | Oral care compositions containing grapefruit seed extract |
| CN101181208A (en) * | 2007-11-20 | 2008-05-21 | 美晨集团股份有限公司 | Gargle containing natural antibiotics and preparation method thereof |
| CN101416926A (en) * | 2008-11-21 | 2009-04-29 | 福建福泽医药器械科技有限公司 | Grapefruit mouth spraying agent and preparation method thereof |
| CN102512345A (en) * | 2011-12-28 | 2012-06-27 | 美晨集团股份有限公司 | Natural antibacterial gargle and preparation method thereof |
| CN103330673A (en) * | 2013-07-09 | 2013-10-02 | 孙佳丽 | Edible mouthwash for childeren |
Non-Patent Citations (2)
| Title |
|---|
| 王建新: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
| 王建新: "《天然活性化妆品》", 31 August 1997, 中国轻工业出版社 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106821950A (en) * | 2017-01-23 | 2017-06-13 | 衡阳美娇七商贸有限公司 | The oral care composition and its application of a kind of antibacterial and whitening |
| CN106580836A (en) * | 2017-01-24 | 2017-04-26 | 广州薇美姿实业有限公司 | Oral care composition containing plant factor and application thereof |
| CN106580836B (en) * | 2017-01-24 | 2019-06-25 | 广州薇美姿实业有限公司 | A kind of oral care composition and its application containing plant factor |
| CN106691944A (en) * | 2017-01-25 | 2017-05-24 | 江苏诺兴生物科技有限公司 | Antibacterial and antiviral composition and application thereof |
| CN108743473A (en) * | 2018-06-28 | 2018-11-06 | 吉林省登泰克牙科材料有限公司 | A kind of mouthrinse composition, preparation method and application |
| CN111265580A (en) * | 2020-03-17 | 2020-06-12 | 浙江亲水园生物科技有限公司 | Composition containing grapefruit seed extract, preparation method and application thereof |
| CN111603418A (en) * | 2020-04-23 | 2020-09-01 | 广州宏康医药科技有限公司 | Oral care product capable of lasting freshness and bacteriostasis and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105997615B (en) | 2018-10-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105997615A (en) | Natural and edible children's mouthwash and preparation method thereof | |
| CN102548526B (en) | Dentifrice composition | |
| US20090269288A1 (en) | Black pearl toothpaste | |
| CN102573770A (en) | Isopropyl methyl phenol-containing liquid composition for oral cavity | |
| CN103536497B (en) | A kind of Traditional Chinese medicinal compound collutory and preparation method thereof | |
| WO2004084852A1 (en) | Nontoxic dental care herbal formulation for preventing dental plaque and gingivitis | |
| CN108938501A (en) | Chinese medicine composition and oral care product applied to oral care product | |
| CN102512345A (en) | Natural antibacterial gargle and preparation method thereof | |
| CN105832614B (en) | A kind of edible natural children's toothpaste and preparation method | |
| KR101778058B1 (en) | Composition for sanitation promotion of oral cavity comprising natural medicinal ingredient extract as effective component for halitosis inducing microoranism and infectious disease of mucous membrane | |
| KR20200012181A (en) | Toothpaste composition comprising herbal extract mixture as effective component | |
| KR20180081032A (en) | Composition for prevention or treatment of oral disease comprising Pueraria Extract | |
| CN103599182A (en) | Traditional Chinese medicine composition and preparation method thereof, and oral cavity cleaning and nursing product and preparation method thereof | |
| KR101664810B1 (en) | Oral composition and manufacturing method thereof | |
| KR101202302B1 (en) | Composition for treating and preventing periodontal disease and caries comprising bee venom | |
| KR20170103476A (en) | Composition for prevention or treatment of oral disease comprising ROSAE LAEVIGATAE Extract | |
| CN110200824A (en) | A kind of sugar-free toothpaste and its production method containing resveratrol | |
| CN104983610B (en) | A kind of product formula for anti-caries removing abnormal flavor in oral cavity | |
| EP1641537A1 (en) | Nontoxic dental care herbal formulation for preventing dental plaque and gingivitis | |
| KR20170103482A (en) | Composition for prevention or treatment of oral disease comprising Glechoma hederacea extract | |
| KR20170103494A (en) | Composition for prevention or treatment of oral disease comprising Melonis Pedicellus Extract | |
| KR101818211B1 (en) | Composition for prevention or treatment of oral disease comprising Arctill fructus Extract | |
| KR102115575B1 (en) | Composition for prevention or treatment of oral disease comprising extracts of Artemisiae Annuae and Bamboo salts | |
| KR20170141057A (en) | Composition for prevention or treatment of dental disease comprising an extract of Daphne genkwa | |
| KR20170142975A (en) | Composition for prevention or treatment of oral disease comprising Leonurus sibiricus extract |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |