CN101181208A - Gargle containing natural antibiotics and preparation method thereof - Google Patents
Gargle containing natural antibiotics and preparation method thereof Download PDFInfo
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- CN101181208A CN101181208A CNA2007100315266A CN200710031526A CN101181208A CN 101181208 A CN101181208 A CN 101181208A CN A2007100315266 A CNA2007100315266 A CN A2007100315266A CN 200710031526 A CN200710031526 A CN 200710031526A CN 101181208 A CN101181208 A CN 101181208A
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Abstract
The invention provides a mouthwash containing natural antibiotics, including 0.01 to 10 weight percent antibacterial agent, 0.01 to 10 weight percent chrysanthemum extract liquid and appropriate amount of water, and the antibacterial agent is the extract which is extracted form citrus plants. The mouthwash of the invention has lasting and effective antibacterial effect, no toxicity or side effects on human body and comfortable taste, which is in line with the requirements of green environmental protection. At the same time, the invention further provides a preparation method of the mouthwash containing natural antibiotics.
Description
Technical field
The present invention relates to a kind of household chemicals, particularly a kind of collutory and preparation method thereof.
Background technology
Existing antibiotic collutory mainly adopts chemical antibacterial of interpolation or Chinese medicine antibacterial to reach antimicrobial effect.
The common chemical antibacterial has triclosan (2,4,4-three chloro-2 dihydroxy diphenyl ethers), hibitane (chlorhexidine), PVP-iodine (polyvidone-iodine) etc.Triclosan has the effect of killing and inhibitory action for general common antibacterial, fungus, and pathogen such as yeast.Under quite low concentration multiple gram positive bacteria and gram negative bacteria are all had good the killing property that presses down, triclosan all has efficient inhibitory or killing effect to multiple fungus and virus, and effect is rapid.Hibitane has great broad-spectrum antibacterial, bactericidal action, is a kind of medicine of sterilizing preferably, and is stronger than disinfectants such as bromo geramines to the antibacterial action of Gram-positive and negative bacterium, even still effective when having serum, blood etc. to exist.PVP-iodine all can use at human and veterinary medicine, is used for killing various antibacterials, pathogenic bacteria, fungus, protozoa and yeast, and some insecticide is effective too for suppressing.
But also there are some shortcomings in chemical antibacterial.At first chemical antibacterial still is confined to the antimicrobial mechanism of slow release, and action time is short, under the situation of slow-releasing agent quantity not sufficient, can cause the drug-fast problem of microorganism.Secondly, chemical antibacterial has toxicity to the mankind itself.The 3rd, chemical antibacterial all is a kind of chemical mixture basically, and the oral cavity short-term is used can eliminate oral cavity bacterium, but life-time service can make tooth discoloration, and the oral cavity becomes dry.The 4th, the biodegradability of chemical antibacterial is poor, and is bigger to the pollution of environment.The 5th, the influence of other material produced antagonistic effect in chemical antibacterial was subject to fill a prescription.
The antimicrobial fluid that Chinese medicine antibacterial commonly used has Herba Senecionis Scandentis, Rhizoma Smilacis Glabrae, Cacumen Securinegae Suffruticosae, Folium pterocaryae stenopterae, hops etc. to make, non-stimulated to the human body skin mucosa, have no side effect, soluble in water, instant effect, applied widely.But its color is darker, and is bigger to the influence of product opaque products; Simultaneously Chinese medicine self contains multiple tannin, and the pained and convergence sense that tannin causes makes the mouthfeel variation.
Summary of the invention
Based on the deficiencies in the prior art, one of purpose of the present invention is to provide a kind of collutory that contains natural antibiotics, and antibacterial effect is effective lastingly, and human body is had no side effect, and comfortable taste meets environment protection requirement.The present invention simultaneously also provides a kind of preparation to contain the method for the collutory of natural antibiotics.
The present invention is for realizing above-mentioned technical purpose, and the method that provides a kind of preparation to contain the collutory of natural antibiotics may further comprise the steps:
(1) the citrus plant fruit is cleaned, removed moisture, be crushed to Emulsion with grinder;
(2) with centrifugal drying equipment Emulsion is dried to 1/8th of former weight;
(3) glycerol of adding 30wt% in emulsifiable concentrates, mix homogeneously left standstill 72 hours, shook at random during leaving standstill 10 minutes;
(4) with 120 order centrifugal filtration emulsifiable concentratess, remove filtering residue;
(5) add enough lactic acid in the clean solution after filtration, regulate pH value to 2.2～3.2, obtain natural antibacterial agent;
(6) adopt supercritical CO
2Extraction and separation technology extracts Flos Chrysanthemi Indici, obtains chrysanthemum extract liquid;
(7) with natural antibacterial agent, chrysanthemum extract liquid and an amount of water mix homogeneously;
(8) mixture that step (7) is obtained filter, fill, obtain product.
Preferably, also can add wetting agent, ethanol, sweeting agent, caries preventive agent, essence, Mentholum in the step (7).
Wetting agent described in the step (1) is a kind of or combination in sorbitol, glycerol or the propylene glycol, described sweetener is a kind of or combination in Sucralose, aspartame or the acesulfame potassium, and described caries preventive agent is a kind of or combination in sodium fluoride, sodium monofluorophosphate or the stannous fluoride.
Citrus plant described in the step (1) is a kind of of Citrus, Fructus Citri Limoniae, grapefruit or Fructus Citri grandis or combination.
The preparation method that the present invention contains the collutory of natural antibiotics adopts the raw material Environmental Safety, and is simple for process, is fit to the large-scale production of industry.
The present invention also provides the collutory that contains natural antibiotics a kind of as that above-mentioned preparation method obtains, comprises natural antibacterial agent 0.01～10wt%, and chrysanthemum extract liquid 0.01～10wt% and water are an amount of, and described natural antibacterial agent is the extract that extracts from citrus plant; Described chrysanthemum extract liquid is for adopting supercritical CO
2The extracting solution that the extract and separate Flos Chrysanthemi Indici obtains.
Preferably, described citrus plant is a kind of of Citrus, Fructus Citri Limoniae, grapefruit or Fructus Citri grandis or combination.
Preferably, described collutory also comprises wetting agent 10～15wt%, edible ethanol 10～20wt%, and sweetener 0～1.0wt%, caries preventive agent 0～0.1wt%, essence, Mentholum and pigment are an amount of.
Described wetting agent is a kind of or combination in sorbitol, glycerol or the propylene glycol, and described sweetener is a kind of or combination in Sucralose, aspartame or the acesulfame potassium, and described caries preventive agent is a kind of or combination in sodium fluoride, sodium monofluorophosphate or the stannous fluoride.
More preferably, described collutory comprises natural antibacterial agent 0.05～5wt%, chrysanthemum extract liquid 0.05～5wt%, wetting agent 10～12wt%, edible ethanol 10～15wt%, sweetener 0～0.5wt%, caries preventive agent 0～0.05wt%, essence, Mentholum and pigment are an amount of, and water is an amount of.
Compared with prior art, its antimicrobial component of collutory that contains natural antibiotics provided by the invention mainly is natural antibacterial agent and the chrysanthemum extract liquid that extracts from citrus plant.Natural antibacterial agent utilizes the natural plants raw bactericidal material, and is nontoxic to human body and animal, can be not carcinogenic or the induced gene sudden change, have the persistent characteristics of antibacterial action simultaneously.
Chrysanthemum extract liquid is extracted by Flos Chrysanthemi Indici, and the medicinal part of Flos Chrysanthemi Indici mainly is a head inflorescence, and it mainly contains effective constituent for waving branch oil, flavone and lactone three major types.Effective chemical analysis of chrysanthemum extract liquid is mainly Borneolum Syntheticum, Borneolum Syntheticum, carvone, cineole, caryophyllene etc., it is reported that these materials have detoxifcation, antibiotic, antiinflammatory, antiviral and promote function such as leukocytes phagocytic.The function of Flos Chrysanthemi Indici heat-clearing and toxic substances removing, anti-inflammation is widely used in clinical medicine, to be decocted in water for oral dose or to make modes such as extractum, suppository, injection, tablet, the clean injection of pyretic toxicity, be used for the treatment of furuncle, all positive disease abscess in ear,nose ﹠ throat oral cavity, pyretic toxicity eczema, summertime furuncle, hot conjunctival congestion with ophthalmalgia, anti-curing cold, influenza, meningitis and treat acute urinary system infection, acute mastitis, liver-heat type hypertension etc.Application medically is for Flos Chrysanthemi Indici provides scientific basis in the daily chemical products application.The Flos Chrysanthemi Indici extracting solution has further promoted the function of oral-cavity article on mouth care, to the cleaning in oral cavity, pure and fresh, diminish inflammation, dispel implication and offer help.
Chrysanthemum extract liquid can suppress general pathogenic bacterium such as golden Portugal bacterium, escherichia coli, dysentery bacterium, also can suppress the growth of streptococcus, lactobacillus etc.Add chrysanthemum extract liquid in the present invention contains the collutory of natural antibiotics, produce synergism with natural antibiotics, antibacterial effect is better, and mouthfeel is more comfortable, and has biodegradability.
Contain in the collutory of natural antibiotics in the present invention, also can add wetting agent, edible ethanol, sweetener, caries preventive agent etc.Wetting agent is given product " body constitution sense ", is suppressed on the bottle cap and separates out crystallization because of water evaporates.Sorbitol and glycerol mouthfeel are little sweet, are fit to the needs of mouthfeel, and cost performance is also better.Edible ethanol has to be stimulated and pure and fresh sense, strengthens the effect of spice, helps to make the dissolving of some spice, and cleaning action and bactericidal action are had contribution.Sweeting agent adopts some novel sweeting agents, replace traditional sucrose and saccharin sodium as acesulfame-K, aspartame etc., make it have sugariness height, consumption is few, heat is low characteristics, these sweeting agents therefore can fine opposing and caries prevention owing to be not the suitable substrates of oral cavity bacterium simultaneously.The mechanism of action of caries preventive agent: after fluoride and the enamel effect, form fluor-apatite at enamel surface, thereby improved adamantine hardness, improved antacid ability; On the other hand, can suppress the breeding of oral cavity bacterium, reduce the formation of bacterial plaque.
For making the present invention easier to understand, further set forth the specific embodiment that the present invention contains the collutory and preparation method thereof of natural antibiotics below in conjunction with accompanying drawing.
Description of drawings
Fig. 1 contains the supercritical CO of the collutory preparation method ZHONGJUHUA extracting solution of natural antibiotics for the present invention
2Extract and separate preparation technology's flow chart;
Fig. 2 is the gas chromatogram of the chrysanthemum extract liquid that adopts preparation technology shown in Figure 1 and make.
The specific embodiment
Below the disclosed preferred embodiment that only contains the collutory and preparation method thereof of natural antibiotics for the present invention, certainly can not limit the present invention's interest field with this, therefore the equivalent variations of being done according to the present patent application claim still belongs to the scope that the present invention is contained.
Embodiment 1
Contain in the specific embodiment of collutory preparation method of natural antibiotics in the present invention, may further comprise the steps:
(1) double centner Citrus fruit is cleaned, removed moisture, be crushed to Emulsion with grinder;
(2) with centrifugal drying equipment Emulsion is dried to 1/8th of former weight;
(3) glycerol of adding 30% weight in emulsifiable concentrates, mix homogeneously left standstill 72 hours, was leaving standstill
Shook at random during this time 10 minutes;
(4) with 120 order centrifugal filtration emulsifiable concentratess, remove filtering residue;
(5) add enough lactic acid in the clean solution after filtration, regulate pH value to 2.2～3.2, obtain natural antibacterial agent;
(6) adopt supercritical CO
2Extraction and separation technology extracts Flos Chrysanthemi Indici, obtains chrysanthemum extract liquid;
(7) sorbitol 10wt%, part ethanol 10wt%, aspartame 1.0wt%, sodium fluoride 0.1wt%, chrysanthemum extract liquid 0.01wt%, essence, Mentholum is an amount of, natural antibacterial agent 0.01wt% and pigment mixing and stirring;
(8) mixture that step 7 is obtained filter, fill, obtain product.
Product contains the collutory of natural antibiotics, comprise natural antibacterial agent 0.01wt%, chrysanthemum extract liquid 0.01wt%, sorbitol 10wt%, ethanol 10wt%, aspartame 1.0wt%, sodium fluoride 0.1wt%, essence, Mentholum, pigment is an amount of and water is an amount of, described natural antibacterial agent is the extract that extracts from Citrus, and chrysanthemum extract liquid is for adopting supercritical CO
2The extracting solution that the extract and separate Flos Chrysanthemi Indici obtains.
Contain in another specific embodiment of collutory preparation method of natural antibiotics in the present invention, may further comprise the steps:
Step (1) to (6) is identical with embodiment 1, and its difference only is to adopt in the present embodiment step (1) the Fructus Citri Limoniae fruit as raw material;
(7) glycerol 15%, part ethanol 20wt%, acesulfame potassium 0.1%, sodium monofluorophosphate 0.01%, chrysanthemum extract liquid 10wt%, essence and Mentholum is an amount of, natural antibacterial agent 10wt%, an amount of mixing and stirring of pigment, described antibacterial be the extract from the Fructus Citri Limoniae extraction;
(8) mixture that step 7 is obtained filter, fill, obtain product.
Product contains the collutory of natural antibiotics, comprise antibacterial 10wt%, chrysanthemum extract liquid 10wt%, glycerol 15%, ethanol 20wt%, acesulfame potassium 0.1%, sodium monofluorophosphate 0.01%, essence, Mentholum, pigment is an amount of and water is an amount of, described antibacterial is the extract that extracts from Fructus Citri Limoniae, and chrysanthemum extract liquid is for adopting supercritical CO
2The extracting solution that the extract and separate Flos Chrysanthemi Indici obtains.
Embodiment 3
Contain in another specific embodiment of collutory preparation method of natural antibiotics in the present invention, may further comprise the steps:
Step (1) to (6) is identical with embodiment 1, and its difference only is to adopt in the present embodiment step (1) 50 kilograms of Fructus Citri Limoniaes and 50 kilograms of citrusfruits as raw material;
(7) propylene glycol 12wt%, ethanol 15%, Sucralose 0.5wt%, stannous fluoride 0.05wt%, chrysanthemum extract liquid 1%, essence and Mentholum is an amount of, natural antibacterial agent 0.05wt%, an amount of mixing and stirring of pigment, described natural antibacterial agent is the extract from Fructus Citri Limoniae and Citrus extraction
(8) mixture that step 7 is obtained filter, fill, obtain product.
Product contains the collutory of natural antibiotics, comprise antibacterial 0.05wt%, chrysanthemum extract liquid 1wt%, propylene glycol 12wt%, part ethanol 15%, Sucralose 0.5wt%, stannous fluoride 0.05wt%, essence, Mentholum, pigment is an amount of and water is an amount of, described antibacterial is that chrysanthemum extract liquid is for adopting supercritical CO from the extract of Fructus Citri Limoniae and Citrus extraction
2The extracting solution that the extract and separate Flos Chrysanthemi Indici obtains.
In above embodiment, wetting agent can be a kind of or combination in sorbitol, glycerol or the propylene glycol, sweetener can be a kind of or combination in Sucralose, aspartame or the acesulfame potassium, and described caries preventive agent is a kind of or combination in sodium fluoride, sodium monofluorophosphate or the stannous fluoride.Antibacterial can be from the extract of a kind of of Citrus, Fructus Citri Limoniae, grapefruit or Fructus Citri grandis or combination extraction.Preferably, the composition of collutory comprises antibacterial 0.05～5wt%, chrysanthemum extract liquid 0.05～5wt%, wetting agent 10～12wt%, edible ethanol 10～15wt%, sweetener 0～0.5wt%, caries preventive agent 0～0.05wt%, essence, Mentholum and pigment are an amount of, and water is an amount of.
The preparation method that the present invention contains the collutory of natural antibiotics adopts the raw material Environmental Safety, and is simple for process, is fit to the large-scale production of industry.It is effective lastingly that the present invention contains the collutory antibacterial effect of natural antibiotics, and human body is had no side effect, and comfortable taste meets environment protection requirement.
Embodiment 4
The extracting method of chrysanthemum extract liquid
Flos Chrysanthemi Indici is the head inflorescence of feverfew Herba Dendranthematis indici Dendranthema indicum (L.) Des Moul., belongs to perennial herb, is born in by patana, shrubbery, river bank meadow bog, beach salt lick and the field wing.Be widely distributed in northeast, North China and southwest.Flos Chrysanthemi Indici bitter in the mouth, cold nature are gone into lung, Liver Channel.The tool heat-clearing and toxic substances removing, the effect of dispelling wind suppressing the hyperactive liver.
For the merit of the wind and heat dispersing of Flos Chrysanthemi Indici, how on the books China's this agrostology monograph at all times is.Put down in writing in the Compendium of Material Medica: Flos Chrysanthemi Indici " bitter, hot, warm, it is swollen to control pain, treats poison, scrofula, eye Xi ".Record in " book on Chinese herbal medicine converge with speech ": Flos Chrysanthemi Indici " the gas cold, removing blood stasis is soothing the liver, separate treat the poison that looses medicine also, stagnated blood in housewife people's abdomen, the capable fire-toxin pellet of Xie Tian furuncle is smash juice and living wine is obeyed it; Or get Zi Fu An and also imitate.Boil soup and wash the skin ulcer scabies, can remove the wind parasite killing again." " book on Chinese herbal medicine just " claim that also Flos Chrysanthemi Indici can " fire that looses loose gas, eliminating carbuncle poison, swollen, the scrofula of furuncle, eyes burning pain "." Sichuan Chinese medicinal herbal " nineteen eighty-two version is also carried: Flos Chrysanthemi Indici " dispelling wind, heat clearing away, detoxifcation.Be used for flu, skin ulcer pain toxic swelling, laryngopharynx swelling and pain, wind-fire acute conjunctivitis, jaundice due to damp-heat, liver-heat type hypertension ".The Pharmacopoeia of the People's Republic of China is stated its heat-clearing and toxic substances removing also with its income, returns the effect of liver, heart channel.
The effects for removing toxic heat of Flos Chrysanthemi Indici excellence, by wide clinical application in section's diseases such as inside and outside, the woman of medical science, youngsters.Utilize these drug effects of Flos Chrysanthemi Indici to be applied to other field, as the daily-use chemical industry industry, especially oral cavity health nursing aspect has positive effect.The utilization supercritical CO
2Extracting process extracts the Flos Chrysanthemi Indici elite, explores the modern extraction method of traditional Chinese herbal medicine, and Flos Chrysanthemi Indici extract is applied to oral care product---on the collutory,, traditional Chinese herbal medicine provides scientific basis for being applied to modern oral health-care product.
1. the medicinal part of Flos Chrysanthemi Indici mainly is a head inflorescence, and its main active ingredient is for waving branch oil, flavone and lactone three major types.The extracting method of traditional Flos Chrysanthemi Indici working substance is water alcohol extraction and alcohol extraction crystallization process, and these two kinds of methods are low to the working substance extraction ratio of Flos Chrysanthemi Indici, and color and luster is dark, and making an addition to influences outward appearance on the tooth paste product.We are with supercritical CO
2Extraction and separation technology is applied under condition of high voltage, utilize CO in the extraction of Flos Chrysanthemi Indici working substance
2Physical property conversion of energy under critical shape circle of low temperature promptly has good extraction ability, and the working substance of Flos Chrysanthemi Indici is carried out extract and separate, obtains the Flos Chrysanthemi Indici working substance volatile oil of high-load, lighter color, for next step product testing is laid a good foundation.The Flos Chrysanthemi Indici supercritical CO
2Extraction and separation technology such as Fig. 1.
2. to utilizing supercritical CO
2The Flos Chrysanthemi Indici extracting solution that extraction and separation technology extracts carries out gas chromatographic analysis, its gas chromatogram such as Fig. 2.Its effective chemical analysis is mainly Borneolum Syntheticum, Borneolum Syntheticum, carvone, cineole, caryophyllene etc., it is reported that these materials have functions such as detoxifcation, antibiotic, antiinflammatory, antiviral and promotion leukocytes phagocytic thereof.
Embodiment 5
The bacteriostatic test that contains the collutory of natural antibiotics
Adopt 2002 editions antibacterial ring tests of " disinfection technology standard " 2.1.8.2 of Ministry of Health of the People's Republic of China.
| The sample title | The test strain | Parallel test | Antibacterial ring size (mm) |
| The collutory (containing chrysanthemum extract liquid 1.0 wt% and natural antibacterial agent 0.1wt%) that contains natural antibiotics | Escherichia coli 8099 (Escherichia coli) | For the first time | 7.1 |
| For the second time | 7.2 | ||
| For the third time | 7.1 | ||
| Staphylococcus aureus (Staphylococcusaureus) ATCC 6538 | For the first time | 10.3 | |
| For the second time | 10.0 | ||
| For the third time | 10.1 | ||
| Candida albicans (Candida albicans) ATCC 10231 | For the first time | 10.2 | |
| For the second time | 9.9 | ||
| For the third time | 10.1 | ||
| Chrysanthemum extract liquid 1.0 wt% | Escherichia coli 8099 (Escherichia coli) | For the first time | 1.0 |
| For the second time | 1.1 | ||
| For the third time | 0.9 | ||
| Staphylococcus aureus Staphylococcusaureus) ATCC 6538 | For the first time | 1.5 | |
| For the second time | 1.4 | ||
| For the third time | 1.4 | ||
| Candida albicans (Candida albicans) ATCC 10231 | For the first time | 1.3 | |
| For the second time | 1.2 | ||
| For the third time | 1.3 |
| Natural antibacterial agent 0.1 wt% | Escherichia coli 8099 (Escherichia coli) | For the first time | 3.5 |
| For the second time | 3.3 | ||
| For the third time | 3.4 | ||
| Staphylococcus aureus (Staphylococcusaureus) ATCC 6538 | For the first time | 5.2 | |
| For the second time | 5.1 | ||
| For the third time | 5.1 | ||
| Candida albicans (Candida albicans) ATCC 10231 | For the first time | 4.9 | |
| For the second time | 4.9 | ||
| For the third time | 5.0 |
The result shows, adds chrysanthemum extract liquid and natural antibacterial agent in collutory, has significant synergetic antibacterial effect.
Claims (9)
1. method for preparing the collutory that contains natural antibiotics may further comprise the steps:
(1) the citrus plant fruit is cleaned, removed moisture, be crushed to Emulsion with grinder;
(2) with centrifugal drying equipment Emulsion is dried to 1/8th of former weight;
(3) glycerol of adding 30wt% in emulsifiable concentrates, mix homogeneously left standstill 72 hours, shook at random during leaving standstill 10 minutes;
(4) with 120 order centrifugal filtration emulsifiable concentratess, remove filtering residue;
(5) add enough lactic acid in the clean solution after filtration, regulate pH value to 2.2～3.2, obtain natural antibacterial agent;
(6) adopt supercritical CO
2Extraction and separation technology extracts Flos Chrysanthemi Indici, obtains chrysanthemum extract liquid;
(7) with natural antibacterial agent, chrysanthemum extract liquid and an amount of water mix homogeneously;
(8) mixture that step (7) is obtained filter, fill, obtain product.
2. preparation as claimed in claim 1 contains the method for the collutory of natural antibiotics, it is characterized in that step
(7) also can add wetting agent, ethanol, sweeting agent, caries preventive agent, essence, Mentholum in.
3. preparation as claimed in claim 2 contains the method for the collutory of natural antibiotics, it is characterized in that step
(1) wetting agent described in is a kind of or combination in sorbitol, glycerol or the propylene glycol, and described sweetener is a kind of or combination in Sucralose, aspartame or the acesulfame potassium, and described caries preventive agent is a kind of or combination in sodium fluoride, sodium monofluorophosphate or the stannous fluoride.
4. preparation as claimed in claim 1 contains the method for the collutory of natural antibiotics, it is characterized in that step
(1) citrus plant described in is a kind of of Citrus, Fructus Citri Limoniae, grapefruit or Fructus Citri grandis or combination.
5. the product as claim 1 preparation method contains the collutory of natural antibiotics, comprises
Natural antibacterial agent 0.01～10wt%,
Chrysanthemum extract liquid 0.01～10wt%,
Water is an amount of,
Described natural antibacterial agent is the extract that extracts from citrus plant, and described chrysanthemum extract liquid is for adopting supercritical CO
2The extracting solution that the extract and separate Flos Chrysanthemi Indici obtains.
6. the collutory that contains natural antibiotics as claimed in claim 5 is characterized in that, described citrus plant is a kind of of Citrus, Fructus Citri Limoniae, grapefruit or Fructus Citri grandis or combination.
7. the collutory that contains natural antibiotics as claimed in claim 5 is characterized in that described collutory also comprises
Wetting agent 10～15wt%,
Edible ethanol 10～20wt%,
Sweetener 0～1.0wt%,
Caries preventive agent 0～0.1wt%,
Essence, Mentholum and pigment are an amount of.
8. the collutory that contains natural antibiotics as claimed in claim 7, it is characterized in that, described wetting agent is a kind of or combination in sorbitol, glycerol or the propylene glycol, described sweetener is a kind of or combination in Sucralose, aspartame or the acesulfame potassium, and described caries preventive agent is a kind of or combination in sodium fluoride, sodium monofluorophosphate or the stannous fluoride.
9. the collutory that contains natural antibiotics as claimed in claim 7 is characterized in that described collutory comprises
Natural antibacterial agent 0.05～5wt%,
Chrysanthemum extract liquid 0.05～5wt%,
Wetting agent 10～12wt%,
Edible ethanol 10～15wt%,
Sweetener 0～0.5wt%,
Caries preventive agent 0～0.05wt%,
Essence, Mentholum and pigment are an amount of,
Water is an amount of.
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| CN102512345A (en) * | 2011-12-28 | 2012-06-27 | 美晨集团股份有限公司 | Natural antibacterial gargle and preparation method thereof |
| CN104027913A (en) * | 2014-06-06 | 2014-09-10 | 中国矿业大学(北京) | Composite oxidation inhibitor for preventing spontaneous combustion of coal gangue and application amount thereof |
| CN105997615A (en) * | 2016-05-16 | 2016-10-12 | 上海儿童营养中心有限公司 | Natural and edible children's mouthwash and preparation method thereof |
| CN108743473A (en) * | 2018-06-28 | 2018-11-06 | 吉林省登泰克牙科材料有限公司 | A kind of mouthrinse composition, preparation method and application |
| CN112353831A (en) * | 2020-11-23 | 2021-02-12 | 象鼻山香(杭州)生物科技有限公司 | Effective part of chrysanthemum indicum leaf for relieving blood pressure and application |
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Family Cites Families (3)
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| WO2000065911A1 (en) * | 1999-04-30 | 2000-11-09 | Sintal International, Inc. | Anti-bacterial composition and use thereof for skin care and fabric treatment |
| CN1093398C (en) * | 1999-07-22 | 2002-10-30 | 刘思强 | Shaddock radish face-washing milk |
| CN1242762C (en) * | 2003-09-18 | 2006-02-22 | 江苏扬子江药业集团有限公司 | Chinese medicine compound spraying agent for treating acute, chronic nasitis and its preparation method |
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| CN102512345A (en) * | 2011-12-28 | 2012-06-27 | 美晨集团股份有限公司 | Natural antibacterial gargle and preparation method thereof |
| CN102512345B (en) * | 2011-12-28 | 2013-09-11 | 美晨集团股份有限公司 | Natural antibacterial gargle and preparation method thereof |
| CN104027913A (en) * | 2014-06-06 | 2014-09-10 | 中国矿业大学(北京) | Composite oxidation inhibitor for preventing spontaneous combustion of coal gangue and application amount thereof |
| CN105997615A (en) * | 2016-05-16 | 2016-10-12 | 上海儿童营养中心有限公司 | Natural and edible children's mouthwash and preparation method thereof |
| CN108743473A (en) * | 2018-06-28 | 2018-11-06 | 吉林省登泰克牙科材料有限公司 | A kind of mouthrinse composition, preparation method and application |
| CN112353831A (en) * | 2020-11-23 | 2021-02-12 | 象鼻山香(杭州)生物科技有限公司 | Effective part of chrysanthemum indicum leaf for relieving blood pressure and application |
| CN115400069A (en) * | 2021-05-28 | 2022-11-29 | 刘宗平 | Oral fresh preparation capable of efficiently inhibiting and inactivating helicobacter pylori in oral cavity |
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