CN102512345B - Natural antibacterial gargle and preparation method thereof - Google Patents
Natural antibacterial gargle and preparation method thereof Download PDFInfo
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- CN102512345B CN102512345B CN 201110446807 CN201110446807A CN102512345B CN 102512345 B CN102512345 B CN 102512345B CN 201110446807 CN201110446807 CN 201110446807 CN 201110446807 A CN201110446807 A CN 201110446807A CN 102512345 B CN102512345 B CN 102512345B
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- essential oil
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- mixed liquor
- rhizoma curcumae
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Abstract
The invention discloses a natural antibacterial gargle. The gargle contains an acceptable additive in the gargle, turmeric essential oil and a wild chrysanthemum flower extract. The turmeric essential oil and the wild chrysanthemum flower extract are added into the gargle, and a good antibacterial effect is achieved by using better antibacterial activities of the turmeric essential oil and the wild chrysanthemum flower extract and a synergistic bacterial inhibition effect obtained after the turmeric essential oil and the wild chrysanthemum flower extract are compounded; moreover, the unique aroma of Chinese herbal medicines is formed to serve as the aroma of the gargle by taking the aroma of the turmeric essential oil as main aroma and the chrysanthemum aroma of the wild chrysanthemum flower extract as auxiliary aroma, so synthetic essences are not added, and the gargle is safer and healthier. Meanwhile, the invention also provides a preparation method for the natural antibacterial gargle. The preparation method is easy to operate and realize.
Description
Technical field
The present invention relates to a kind of collutory and preparation method thereof, especially a kind of collutory that contains the composite natral bateriostatics and preparation method thereof.
Background technology
Oral disease is by the various microbial common frdquently encountered diseases that cause a disease in the oral cavity, directly influences the healthy of people.People also prevent the generation of oral disease for a long time by various oral care products.At present, major product in the detergents and cosmetic mouth care can be divided into toothpaste, collutory and flavorants, these products mainly play cleaning teeth, tooth-whitening, removal dental plaque, kill effects such as oral cavity noxious bacteria, caries prevention, fresh breath, simultaneously certain positive role are also played in the treatment as some oral diseases such as various focusing depths represented.Also have some other chewing gum as foodstuff, edible implication cleaning sheet etc. also to have more than the above-mentioned work or few effect.
Collutory is by ethanol, water, wetting agent, spice, solubilizing agent and comprise that the additive of various antipathogenic compositions dissolves the liquid of forming.Along with the raising of people's quality of life, collutory also gos deep into people's life gradually.Its major function is pure and fresh oral cavity, kills or suppress the noxious bacteria in oral cavity.
Existing collutory is by having added chemical antibacterial or extracts of Chinese herbal medicine, and the ethanol of composite high level reaches the effect of anti-inflammation simultaneously.Wherein the ethanol consumption is excessive will cause intense stimulus to oral mucosa, and existing product has all added compound essence and adjusted mouthfeel, and the use compound essence too much in the product kind of entrance type may have potential threat to health.
The common chemical antibacterial has triclosan (2,4,4-, three chloro-2-dihydroxy diphenyl ethers), hibitane (chlorhexidine), metronidazole etc. in the existing collutory.They all have with general common pathogen such as antibacterial, fungus and yeast basically kills effect and inhibitory action fast than wide spectrum.Under low concentration, multiple gram positive bacteria and gram negative bacteria are all had good pressing down and kill property.But also there are a lot of shortcomings in chemical antibacterial, need work by the slow release of medicament as chemical antibacterial; Because action time is short, under the situation of slow-releasing agent quantity not sufficient, life-time service causes the drug-fast problem of microorganism easily.The chemistry antibacterial has certain toxicity to the mankind itself, the safety deficiency usually; The chemical antibacterial life-time service of a part can make tooth discoloration, and the oral cavity becomes dry.The biodegradability of chemistry antibacterial is relatively poor, and is bigger to the pollution of environment; The chemistry antibacterial belongs to cationic compound mostly, the influence of other material in being subject to fill a prescription, thus antibacterial effect weakens.
The antimicrobial fluid that Chinese medicine antibacterial commonly used has Herba Senecionis Scandentis, Rhizoma Smilacis Glabrae, Cacumen Securinegae Suffruticosae, Folium pterocaryae stenopterae, hops etc. to make in the existing collutory, non-stimulated to the human body skin mucosa, have no side effect, soluble in water, instant effect, the scope of application is wider.But active matter content is low, content is difficult to determine because the Chinese herbal medicine extract that makes of traditional method (as water extraction method, solvent extraction method etc.) inevitably can exist, solvent composition is difficult to remove, gained composition problem such as complexity too, is very easy to influence the use mouthfeel of collutory.If add the mouthfeel that more essence improves product, too much use essence may have potential threat to the health of human body again.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, provide a kind of and contain the natural antibacterial composition, do not contain compound essence, antibacterial effect is collutory preferably; Simultaneously, the present invention also provides a kind of preparation method of described collutory.
For achieving the above object, the technical scheme that the present invention takes is: a kind of natural antibacterial collutory, comprise acceptable additive in the collutory, and described natural antibacterial collutory also comprises Rhizoma Curcumae Longae essential oil and Flos Chrysanthemi Indici extract.
In the natural antibacterial collutory of the present invention, Rhizoma Curcumae Longae essential oil and Flos Chrysanthemi Indici extract have been added, utilize they self better antibacterial activity and composite after synergism reach good antibacterial effect, gained natural antibacterial collutory has no side effect environmental protection to human body.And, wherein only utilize self fragrance of Rhizoma Curcumae Longae essential oil to be the master, the Scent of Chrysanthemum of Flos Chrysanthemi Indici extract is auxilliary, forms a kind of very unique Chinese herbal medicine fragrance, is used as the fragrance of collutory, uses back lips and teeth lasting.Because do not add any compound essence, safety and environmental-protecting performance are more excellent.
As the preferred implementation of natural antibacterial collutory of the present invention, acceptable additive comprises edible ethanol in the described collutory, wetting agent, solubilizing agent, sweeting agent, water and other additives.
As the preferred implementation of natural antibacterial collutory of the present invention, described other additives comprise caries preventive agent, freshener and acid-base modifier.
Preferred implementation as natural antibacterial collutory of the present invention, described collutory comprises the component of following weight portion: 0.1 ~ 2 part of Rhizoma Curcumae Longae essential oil, 0.1 ~ 2 part of Flos Chrysanthemi Indici extract, 0 ~ 25 part of ethanol, 5 ~ 35 parts of wetting agents, 0.1 ~ 5 part of solubilizing agent, 0 ~ 0.5 part of sweeting agent, 0.1 ~ 0.5 part of acid-base modifier, 0.1 ~ 1 part of freshener, 28 ~ 94.6 parts in water.Add Rhizoma Curcumae Longae essential oil, Flos Chrysanthemi Indici extract and the additive of described mass fraction in described natural antibacterial collutory respectively, fungistatic effect and use mouthfeel are better, can be to alleviating various focusing depths represented, alleviate pharyngalgia, promoting the oral ulcer healing that better action is arranged.
As the preferred implementation of natural antibacterial collutory of the present invention, the mass ratio of described Rhizoma Curcumae Longae essential oil and Flos Chrysanthemi Indici extract is 5:1 ~ 2:1.When the mass ratio of described Rhizoma Curcumae Longae essential oil and Flos Chrysanthemi Indici extract is 5:1 ~ 2:1, reach better fungistatic effect and use mouthfeel, the gained collutory is to alleviating various focusing depths represented, alleviate pharyngalgia, promoting the oral ulcer healing that better effect is arranged.
As the preferred implementation of natural antibacterial collutory of the present invention, described wetting agent is at least a in glycerol, propylene glycol, Polyethylene Glycol, the sorbitol; Described solubilizing agent be in polyoxyethylene polyols fatty acid ester (as tween 20, tween 80), the polyoxyethylene hydrogenated Oleum Ricini one or both; Described sweeting agent is at least a in aspartame, acesulfame potassium, steviol glycosides, the sucralose; Described acid-base modifier is one or both in sodium hexameta phosphate, the tetrasodium pyrophosphate; Described freshener is at least a in Mentholum, menthyl lactate, the amide of mint; Described caries preventive agent is at least a in sodium fluoride, sodium monofluorophosphate, xylitol, the stannous fluoride; Described water is deionized water.
As the preferred implementation of natural antibacterial collutory of the present invention, described Rhizoma Curcumae Longae essential oil and Flos Chrysanthemi Indici extract all adopt the supercritical carbon dioxide extraction gained.Supercritical carbon dioxide extraction method is a kind of novel green isolation technics, the temperature of its extraction is not high, isolated with oxygen, be specially adapted to extract the material that is subjected to thermally labile, oxidation easily, pungent fragrance etc. is arranged, there not be the dissolvent residual that is harmful in the extract that adopts the method to obtain.The Rhizoma Curcumae Longae essential oil that adopts the supercritical carbon dioxide extraction method extraction to obtain, outward appearance is as clear as crystal, and fragrance is strong, and it is strong that antibacterial ability extracts the Rhizoma Curcumae Longae essential oil that obtains than additive method.The Flos Chrysanthemi Indici extract that adopts the supercritical carbon dioxide extraction method extraction to obtain obtains content height, lighter color, the Flos Chrysanthemi Indici working substance of specific Scent of Chrysanthemum is arranged, and has effects such as detoxifcation preferably, antibiotic, antiinflammatory, antiviral.Certainly, the Rhizoma Curcumae Longae essential oil and the Flos Chrysanthemi Indici extract that adopt additive method to obtain also can be realized purpose of the present invention, and just color and luster, content and the antibacterial ability of products obtained therefrom do not adopt the good of supercritical carbon dioxide extraction method.
Preferred implementation as natural antibacterial collutory of the present invention, described Rhizoma Curcumae Longae essential oil by the condition of supercritical carbon dioxide extraction is: extracting pressure 15-18MPa, 45 ℃ of extraction temperature, resolve pressure 4.5MPa, 40 ℃ of resolution temperatures, carbon dioxide flow are 20kg/h, time 60min, molecular distillation pressure is 30Pa, 110 ℃ of temperature.When adopting described supercritical carbon dioxide extraction condition, the outward appearance of gained Rhizoma Curcumae Longae essential oil is more as clear as crystal, and fragrance is stronger, and antibacterial ability is stronger.
Preferred implementation as natural antibacterial collutory of the present invention, described Flos Chrysanthemi Indici extract by the condition of supercritical carbon dioxide extraction is: earlier at extracting pressure 15-18MPa, 45 ℃ of extraction temperature, resolve pressure 4.5MPa, carbon dioxide flow is 20kg/h, extract under the condition of time 150min crude extract, be cooled to 3 ~ 8 ℃ of refining purifications after 50 ~ 60 ℃ of dissolvings by being warming up to again.When adopting described supercritical carbon dioxide extraction condition, the composition of the Flos Chrysanthemi Indici working substance with specific Scent of Chrysanthemum that contains in the gained Flos Chrysanthemi Indici extract is higher, has effects such as better detoxifcation, antibiotic, antiinflammatory, antiviral.
The preparation method of natural antibacterial collutory described above provided by the present invention comprises following steps:
(1) with the dissolving fully in water of wetting agent, sweeting agent, caries preventive agent and acid-base modifier, gets the mixed liquor I;
(2) freshener is dissolved in the edible ethanol, will dissolves good solution then and join under stirring condition in the mixed liquor I that step (1) obtains, mix homogeneously gets the mixed liquor II;
(3) Rhizoma Curcumae Longae essential oil, Flos Chrysanthemi Indici extract and solubilizing agent stirring under 40 ~ 45 ℃ is dissolved each other, become transparent oily liquid, slowly join under stirring condition then in the mixed liquor II of step (2) gained, stirring mixes it fully, gets the mixed liquor III;
(4) the mixed liquor III that step (3) is obtained is filtered, and packing namely gets the natural antibacterial collutory.
Natural antibacterial collutory of the present invention, product appearance are yellow or light yellow transparent supernatant liquid, have tangible natural plants medical herbs fragrance, and cool taste is comfortable.During use, an amount of collutory is contained in the entrance, contain a bite clear water then, gargle according to the normal method of gargling, finish liquid is spued after gargling.
Rhizoma Curcumae Longae is a kind of perennial herbaceous plant, widely cultivates in the torrid areas in Asia.In India, Rhizoma Curcumae Longae is applied to treat multiple commonly encountered diseases as a kind of traditional herbal medicines, as body burden promoter, antiseptic, removing human body waste, detoxifcation, removing pruritus, treatment refractory skin (comprising leprosy) etc.Treatment wind dental caries is painful also to have traditional Chinese medical science ancient prescription to put down in writing: pulvis curcumae uses Rhizoma Curcumae Longae, Herba Asari, the Radix Angelicae Dahuricae to be raw material, goes up to be the end, wipes tooth, and the moment spues, and salt soup is gargled; Rhizoma Curcumae Longae pain relieving in the side is monarch drug.People are contained volatile oil (4.2% ~ 14%), fatty oil (4.4% ~ 12.7%) and moisture (10% ~ 12%) by to the discovering of the chemical active ingredient of turmeric powder in the Rhizoma Curcumae Longae.Rhizoma Curcumae Longae is clinical conventional Chinese medicine, in modern pharmacology, has proved multiple effects such as analgesia, antiinflammatory, antifungal, and wherein the Rhizoma Curcumae Longae volatile oil antifungic action is the most obvious.
Flos Chrysanthemi Indici is the head inflorescence of Compositae fabric Herba Dendranthematis indici, belongs to perennial herb.Flos Chrysanthemi Indici bitter in the mouth, cold nature are gone into lung, Liver Channel, have heat-clearing and toxic substances removing, the effect of dispelling wind suppressing the hyperactive liver.As putting down in writing in China's this agrostology monograph Compendium of Material Medica at all times: Flos Chrysanthemi Indici " bitter, hot, warm, it is swollen to control pain, treats poison, and scrofula, eye are flat ".And utilize modernized extracting method, and extract the elite composition of Chinese medicine Flos Chrysanthemi Indici, be applied in mouth care, in collutory, to improving its result of use, increase its using value and have big meaning.
The medicinal part of Flos Chrysanthemi Indici mainly is head inflorescence, and its main effective ingredient is volatile oil, flavone and lactone three major types.The extracting method of traditional Flos Chrysanthemi Indici working substance is water alcohol extraction and alcohol extraction crystallization process, and these two kinds of methods are low to the working substance extraction ratio of Flos Chrysanthemi Indici, and color and luster is dark.We are applied to the supercritical carbon dioxide extraction isolation technics in the extraction of working substance of Flos Chrysanthemi Indici, utilize the critical physical property conversion of energy down of carbon dioxide low temperature, active substance to Flos Chrysanthemi Indici carries out extract and separate, obtain high-load, lighter color, the Flos Chrysanthemi Indici working substance that specific Scent of Chrysanthemum is arranged, its active chemical is mainly Borneolum Syntheticum, Borneolum Syntheticum, carvone, cineole, caryophyllene etc., and these materials have effects such as detoxifcation, antibiotic, antiinflammatory, antiviral and promotion leukocytes phagocytic thereof.
Natural antibacterial collutory of the present invention, Rhizoma Curcumae Longae essential oil and Flos Chrysanthemi Indici extract have been added, utilize they self better antibacterial activity and composite after synergism reach good antibacterial effect, gained collutory fungistatic effect is effective lastingly, can have no side effect to alleviating various focusing depths represented, alleviate pharyngalgia, promoting the oral ulcer healing that better action is arranged, and, because do not add any compound essence, more healthy, environmental protection.The preparation method of natural antibacterial collutory of the present invention, simple to operate, the convenient realization.
Description of drawings
Fig. 1 is preparation technology's flow chart of natural antibacterial collutory of the present invention.
Fig. 2 is the extraction process flow chart of Rhizoma Curcumae Longae essential oil described in the natural antibacterial collutory of the present invention.
Fig. 3 is the extraction process flow chart of Flos Chrysanthemi Indici extract described in the natural antibacterial collutory of the present invention.
The specific embodiment
The purpose, technical solutions and advantages of the present invention the present invention is further described below in conjunction with the drawings and specific embodiments for better illustrating.
Embodiment 1
A kind of natural antibacterial collutory, component by following weight portion is formed: 1 part of Rhizoma Curcumae Longae essential oil, 0.5 part of Flos Chrysanthemi Indici extract, 15 parts of edible ethanols, 10 parts of sorbitol, 5 parts of glycerol, 2 parts of tween 80s, 0.1 part of aspartame, 0.1 part of sodium hexameta phosphate, 0.5 part of Mentholum, 0.1 part of sodium monofluorophosphate, 65.7 parts of deionized waters.
Above-mentioned natural antibacterial collutory is prepared from accordance with the following methods:
(1) with the dissolving fully in deionized water of sorbitol, glycerol, aspartame, sodium monofluorophosphate and sodium hexameta phosphate, gets the mixed liquor I;
(2) Mentholum is dissolved in the edible ethanol, will dissolves good solution then and join under stirring condition in the mixed liquor I that step (1) obtains, mix homogeneously gets the mixed liquor II;
(3) stirring under 40 ~ 45 ℃ of Rhizoma Curcumae Longae essential oil, Flos Chrysanthemi Indici extract and tween 80 is dissolved each other, become transparent oily liquid, slowly join under stirring condition then in the mixed liquor II of step (2) gained, stirring mixes it fully, gets the mixed liquor III;
(4) the mixed liquor III that step (3) is obtained is filtered, and packing namely gets the natural antibacterial collutory.
Described Rhizoma Curcumae Longae essential oil adopts the supercritical carbon dioxide extraction gained, extraction process flow figure as shown in Figure 2, extraction conditions is: extracting pressure 15-18MPa, 45 ℃ of extraction temperature are resolved pressure 4.5MPa, 40 ℃ of resolution temperatures, carbon dioxide flow is 20kg/h, time 60min, molecular distillation pressure are 30Pa, 110 ℃ of temperature.
Described Wild chrysanthemum extract adopts the supercritical carbon dioxide extraction gained, extraction process flow figure as shown in Figure 3, earlier at extracting pressure 15-18MPa, 45 ℃ of extraction temperature, resolve pressure 4.5MPa, carbon dioxide flow is 20kg/h, extract under the condition of time 150min crude extract, be cooled to 3 ~ 8 ℃ of refining purifications after 50 ~ 60 ℃ of dissolvings by being warming up to again.
Embodiment 2
A kind of natural antibacterial collutory, component by following weight portion is formed: 1.5 parts of Rhizoma Curcumae Longae essential oil, 0.5 part of Flos Chrysanthemi Indici extract, 10 parts of edible ethanols, 15 parts of sorbitol, 2.5 parts of tween 80s, 0.1 part of acesulfame potassium, 0.1 part of sodium hexameta phosphate, 0.2 part of menthyl lactate, 0.05 part of sodium fluoride, 70.05 parts of deionized waters.
Above-mentioned natural antibacterial collutory is prepared from accordance with the following methods:
(1) with the dissolving fully in deionized water of sorbitol, acesulfame potassium, sodium fluoride and sodium hexameta phosphate, gets the mixed liquor I;
(2) menthyl lactate is dissolved in the edible ethanol, will dissolves good solution then and join under stirring condition in the mixed liquor I that step (1) obtains, mix homogeneously gets the mixed liquor II;
(3) stirring under 40 ~ 45 ℃ of Rhizoma Curcumae Longae essential oil, Flos Chrysanthemi Indici extract and tween 80 is dissolved each other, become transparent oily liquid, slowly join under stirring condition then in the mixed liquor II of step (2) gained, stirring mixes it fully, gets the mixed liquor III;
(4) the mixed liquor III that step (3) is obtained is filtered, and packing namely gets the natural antibacterial collutory.
Described Rhizoma Curcumae Longae essential oil adopts the supercritical carbon dioxide extraction gained, extraction process flow figure as shown in Figure 2, extraction conditions is: extracting pressure 15-18MPa, 45 ℃ of extraction temperature are resolved pressure 4.5MPa, 40 ℃ of resolution temperatures, carbon dioxide flow is 20kg/h, time 60min, molecular distillation pressure are 30Pa, 110 ℃ of temperature.
Described Wild chrysanthemum extract adopts the supercritical carbon dioxide extraction gained, extraction process flow figure as shown in Figure 3, earlier at extracting pressure 15-18MPa, 45 ℃ of extraction temperature, resolve pressure 4.5MPa, carbon dioxide flow is 20kg/h, extract under the condition of time 150min crude extract, be cooled to 3 ~ 8 ℃ of refining purifications after 50 ~ 60 ℃ of dissolvings by being warming up to again.
Embodiment 3
A kind of natural antibacterial collutory, component by following weight portion is formed: 1 part of Rhizoma Curcumae Longae essential oil, 0.2 part of Flos Chrysanthemi Indici extract, 10 parts of edible ethanols, 15 parts of sorbitol, 2 parts of propylene glycol, 1.5 parts of polyoxyethylene hydrogenated Oleum Ricini, 0.1 part of steviol glycosides, 0.1 part of tetrasodium pyrophosphate, 0.2 part of menthyl lactate, 0.05 part of sodium fluoride, 69.85 parts of deionized waters.
Above-mentioned natural antibacterial collutory is prepared from accordance with the following methods:
(1) with the dissolving fully in deionized water of sorbitol, propylene glycol, steviol glycosides, sodium fluoride and tetrasodium pyrophosphate, gets the mixed liquor I;
(2) menthyl lactate is dissolved in the edible ethanol, will dissolves good solution then and join under stirring condition in the mixed liquor I that step (1) obtains, mix homogeneously gets the mixed liquor II;
(3) stirring under 40 ~ 45 ℃ of Rhizoma Curcumae Longae essential oil, Flos Chrysanthemi Indici extract and polyoxyethylene hydrogenated Oleum Ricini is dissolved each other, become transparent oily liquid, slowly join under stirring condition then in the mixed liquor II of step (2) gained, stirring mixes it fully, gets the mixed liquor III;
(4) the mixed liquor III that step (3) is obtained is filtered, and packing namely gets the natural antibacterial collutory.
Described Rhizoma Curcumae Longae essential oil adopts the supercritical carbon dioxide extraction gained, extraction process flow figure as shown in Figure 2, extraction conditions is: extracting pressure 15-18MPa, 45 ℃ of extraction temperature are resolved pressure 4.5MPa, 40 ℃ of resolution temperatures, carbon dioxide flow is 20kg/h, time 60min, molecular distillation pressure are 30Pa, 110 ℃ of temperature.
Described Wild chrysanthemum extract adopts the supercritical carbon dioxide extraction gained, extraction process flow figure as shown in Figure 3, earlier at extracting pressure 15-18MPa, 45 ℃ of extraction temperature, resolve pressure 4.5MPa, carbon dioxide flow is 20kg/h, extract under the condition of time 150min crude extract, be cooled to 3 ~ 8 ℃ of refining purifications after 50 ~ 60 ℃ of dissolvings by being warming up to again.
Embodiment 4
A kind of natural antibacterial collutory is made up of the component of following weight portion: 0.1 part of Rhizoma Curcumae Longae essential oil, 2 parts of Flos Chrysanthemi Indici extracts, 5 parts of edible ethanols, 5 parts of glycerol, 5 parts of tween 20s, 0.2 part of tetrasodium pyrophosphate, 0.1 part of amide of mint, 82.6 parts of deionized waters.
Above-mentioned natural antibacterial collutory is prepared from accordance with the following methods:
(1) dissolving fully in deionized water with glycerol and tetrasodium pyrophosphate gets the mixed liquor I;
(2) amide of mint is dissolved in the edible ethanol, will dissolves good solution then and join under stirring condition in the mixed liquor I that step (1) obtains, mix homogeneously gets the mixed liquor II;
(3) stirring under 40 ~ 45 ℃ of Rhizoma Curcumae Longae essential oil, Flos Chrysanthemi Indici extract and tween 20 is dissolved each other, become transparent oily liquid, slowly join under stirring condition then in the mixed liquor II of step (2) gained, stirring mixes it fully, gets the mixed liquor III;
(4) the mixed liquor III that step (3) is obtained is filtered, and packing namely gets the natural antibacterial collutory.
Described Rhizoma Curcumae Longae essential oil adopts the supercritical carbon dioxide extraction gained, extraction process flow figure as shown in Figure 2, extraction conditions is: extracting pressure 15-18MPa, 45 ℃ of extraction temperature are resolved pressure 4.5MPa, 40 ℃ of resolution temperatures, carbon dioxide flow is 20kg/h, time 60min, molecular distillation pressure are 30Pa, 110 ℃ of temperature.
Described Wild chrysanthemum extract adopts the supercritical carbon dioxide extraction gained, extraction process flow figure as shown in Figure 3, earlier at extracting pressure 15-18MPa, 45 ℃ of extraction temperature, resolve pressure 4.5MPa, carbon dioxide flow is 20kg/h, extract under the condition of time 150min crude extract, be cooled to 3 ~ 8 ℃ of refining purifications after 50 ~ 60 ℃ of dissolvings by being warming up to again.
Embodiment 5
A kind of natural antibacterial collutory is made up of the component of following weight portion: 2 parts of Rhizoma Curcumae Longae essential oil, 0.1 part of Flos Chrysanthemi Indici extract, 20 parts of edible ethanols, 5 parts of glycerol, 10 parts of propylene glycol, 20 parts of sorbitol, 0.1 part of polyoxyethylene hydrogenated Oleum Ricini, 0.2 part of aspartame, 0.3 part of acesulfame potassium, 0.2 part of sodium hexameta phosphate, 0.2 part of tetrasodium pyrophosphate, 0.5 part of Mentholum, 0.1 part of amide of mint, 0.02 part of xylitol, 41.38 parts of deionized waters.
Above-mentioned natural antibacterial collutory is prepared from accordance with the following methods:
(1) with the dissolving fully in deionized water of glycerol, propylene glycol, sorbitol, aspartame, acesulfame potassium, xylitol, sodium hexameta phosphate and tetrasodium pyrophosphate, gets the mixed liquor I;
(2) Mentholum and amide of mint are dissolved in the edible ethanol, will dissolve good solution then and join under stirring condition in the mixed liquor I that step (1) obtains, mix homogeneously gets the mixed liquor II;
(3) stirring under 40 ~ 45 ℃ of Rhizoma Curcumae Longae essential oil, Flos Chrysanthemi Indici extract and polyoxyethylene hydrogenated Oleum Ricini is dissolved each other, become transparent oily liquid, slowly join under stirring condition then in the mixed liquor II of step (2) gained, stirring mixes it fully, gets the mixed liquor III;
(4) the mixed liquor III that step (3) is obtained is filtered, and packing namely gets the natural antibacterial collutory.
Described Rhizoma Curcumae Longae essential oil adopts the supercritical carbon dioxide extraction gained, extraction process flow figure as shown in Figure 2, extraction conditions is: extracting pressure 15-18MPa, 45 ℃ of extraction temperature are resolved pressure 4.5MPa, 40 ℃ of resolution temperatures, carbon dioxide flow is 20kg/h, time 60min, molecular distillation pressure are 30Pa, 110 ℃ of temperature.
Described Wild chrysanthemum extract adopts the supercritical carbon dioxide extraction gained, extraction process flow figure as shown in Figure 3, earlier at extracting pressure 15-18MPa, 45 ℃ of extraction temperature, resolve pressure 4.5MPa, carbon dioxide flow is 20kg/h, extract under the condition of time 150min crude extract, be cooled to 3 ~ 8 ℃ of refining purifications after 50 ~ 60 ℃ of dissolvings by being warming up to again.
Embodiment 6
A kind of natural antibacterial collutory, component by following weight portion is formed: 1.6 parts of Rhizoma Curcumae Longae essential oil, 0.4 part of Flos Chrysanthemi Indici extract, 25 parts of edible ethanols, 20 parts of propylene glycol, 5 parts of sorbitol, 2 parts of tween 20s, 1 part of polyoxyethylene hydrogenated Oleum Ricini, 0.2 part of aspartame, 0.1 part of steviol glycosides, 0.2 part of sodium hexameta phosphate, 0.3 part of tetrasodium pyrophosphate, 0.5 part of Mentholum, 0.2 part of amide of mint, 0.3 part of menthyl lactate, 0.02 part of sodium fluoride, 0.03 part of stannous fluoride, 0.03 part of xylitol, 43.12 parts of deionized waters.
Above-mentioned natural antibacterial collutory is prepared from accordance with the following methods:
(1) with the dissolving fully in deionized water of propylene glycol, sorbitol, aspartame, steviol glycosides, sodium fluoride, stannous fluoride, xylitol, sodium hexameta phosphate and tetrasodium pyrophosphate, gets the mixed liquor I;
(2) Mentholum, amide of mint and menthyl lactate are dissolved in the edible ethanol, will dissolve good solution then and join under stirring condition in the mixed liquor I that step (1) obtains, mix homogeneously gets the mixed liquor II;
(3) stirring under 40 ~ 45 ℃ of Rhizoma Curcumae Longae essential oil, Flos Chrysanthemi Indici extract and tween 20, polyoxyethylene hydrogenated Oleum Ricini is dissolved each other, become transparent oily liquid, slowly join under stirring condition then in the mixed liquor II of step (2) gained, stirring mixes it fully, gets the mixed liquor III;
(4) the mixed liquor III that step (3) is obtained is filtered, and packing namely gets the natural antibacterial collutory.
Described Rhizoma Curcumae Longae essential oil adopts the supercritical carbon dioxide extraction gained, extraction process flow figure as shown in Figure 2, extraction conditions is: extracting pressure 15-18MPa, 45 ℃ of extraction temperature are resolved pressure 4.5MPa, 40 ℃ of resolution temperatures, carbon dioxide flow is 20kg/h, time 60min, molecular distillation pressure are 30Pa, 110 ℃ of temperature.
Described Wild chrysanthemum extract adopts the supercritical carbon dioxide extraction gained, extraction process flow figure as shown in Figure 3, earlier at extracting pressure 15-18MPa, 45 ℃ of extraction temperature, resolve pressure 4.5MPa, carbon dioxide flow is 20kg/h, extract under the condition of time 150min crude extract, be cooled to 3 ~ 8 ℃ of refining purifications after 50 ~ 60 ℃ of dissolvings by being warming up to again.
Embodiment 7
The bacteriostatic test of natural antibacterial collutory of the present invention
Matched group contains the component of following weight portion: 1 part of Rhizoma Curcumae Longae essential oil, and 15 parts of edible ethanols, 15 parts of wetting agents, 2.5 parts of solubilizing agents, 0.1 part of sweeting agent, 0.1 part of acid-base modifier, 0.2 part of freshener, 0.05 part of caries preventive agent, deionized water add to 100 parts.
Experimental group contains the component of following weight portion: 1 part of Rhizoma Curcumae Longae essential oil, 0.5 part of Flos Chrysanthemi Indici extract, 15 parts of edible ethanols, 15 parts of wetting agents, 2.5 parts of solubilizing agents, 0.1 part of sweeting agent, 0.1 part of acid-base modifier, 0.2 part of freshener, 0.05 part of caries preventive agent, deionized water add to 100 parts.
Adopt 2002 editions antibacterial ring tests of " disinfection technology standard " 2.1.8.2 of Ministry of Health of the People's Republic of China, result of the test sees Table 1.
The contrast of table 1 fungistatic effect
As seen from Table 1, after Rhizoma Curcumae Longae essential oil and Flos Chrysanthemi Indici extract are composite, produce collaborative inhibitory effect preferably.Therefore, the present invention adds Rhizoma Curcumae Longae essential oil and Flos Chrysanthemi Indici extract simultaneously, utilize they self better antibacterial activity and composite after collaborative inhibitory effect, reach good antibacterial effect, and, utilize self fragrance of Rhizoma Curcumae Longae essential oil to be the master, the Scent of Chrysanthemum of Flos Chrysanthemi Indici extract is auxilliary, has formed a kind of very unique Chinese herbal medicine fragrance, be used as the fragrance of collutory, need not add any compound essence, human body is had no side effect, more safety and Health.
The above only is preferred implementation of the present invention but not limiting the scope of the invention; should be understood that; for those skilled in the art; under the prerequisite that does not break away from the principle of the invention; can make amendment or be equal to replacement technical solution of the present invention, these modifications or be equal to replacement and also should be considered as protection scope of the present invention.
Claims (6)
1. natural antibacterial collutory, it is characterized in that, described collutory comprises the component of following weight portion: 0.1～2 part of Rhizoma Curcumae Longae essential oil, 0.1～2 part of Flos Chrysanthemi Indici extract, 0～25 part of edible ethanol, 5～35 parts of wetting agents, 0.1～5 part of solubilizing agent, 0～0.5 part of sweeting agent, 0.1～0.5 part of acid-base modifier, 0.1～1 part of freshener, 28～94.6 parts in water; Described Rhizoma Curcumae Longae essential oil and Flos Chrysanthemi Indici extract all adopt the supercritical carbon dioxide extraction gained; Described natural antibacterial collutory also comprises caries preventive agent.
2. natural antibacterial collutory as claimed in claim 1 is characterized in that, the mass ratio of described Rhizoma Curcumae Longae essential oil and Flos Chrysanthemi Indici extract is 5:1～2:1.
3. natural antibacterial collutory as claimed in claim 1 is characterized in that, described wetting agent is at least a in glycerol, propylene glycol, Polyethylene Glycol, the sorbitol; Described solubilizing agent be in polyoxyethylene polyols fatty acid ester, the polyoxyethylene hydrogenated Oleum Ricini one or both; Described sweeting agent is at least a in aspartame, acesulfame potassium, steviol glycosides, the sucralose; Described acid-base modifier is one or both in sodium hexameta phosphate, the tetrasodium pyrophosphate; Described freshener is at least a in Mentholum, menthyl lactate, the amide of mint; Described caries preventive agent is at least a in sodium fluoride, sodium monofluorophosphate, xylitol, the stannous fluoride; Described water is deionized water.
4. natural antibacterial collutory as claimed in claim 1, it is characterized in that, described Rhizoma Curcumae Longae essential oil by the condition of supercritical carbon dioxide extraction is: extracting pressure 15-18MPa, 45 ℃ of extraction temperature are resolved pressure 4.5MPa, 40 ℃ of resolution temperatures, carbon dioxide flow is 20kg/h, time 60min, molecular distillation pressure are 30Pa, 110 ℃ of temperature.
5. natural antibacterial collutory as claimed in claim 1, it is characterized in that, described Flos Chrysanthemi Indici extract by the condition of supercritical carbon dioxide extraction is: earlier at extracting pressure 15-18MPa, 45 ℃ of extraction temperature, resolve pressure 4.5MPa, carbon dioxide flow is 20kg/h, extract under the condition of time 150min crude extract, be cooled to 3～8 ℃ of refining purifications after 50～60 ℃ of dissolvings by being warming up to again.
6. the preparation method of a natural antibacterial collutory as claimed in claim 1 is characterized in that, comprises following steps:
(1) with the dissolving fully in water of wetting agent, sweeting agent, caries preventive agent and acid-base modifier, gets the mixed liquor I;
(2) freshener is dissolved in the edible ethanol, will dissolves good solution then and join under stirring condition in the mixed liquor I that step (1) obtains, mix homogeneously gets the mixed liquor II;
(3) Rhizoma Curcumae Longae essential oil, Flos Chrysanthemi Indici extract and solubilizing agent stirring under 40～45 ℃ is dissolved each other, become transparent oily liquid, slowly join under stirring condition then in the mixed liquor II of step (2) gained, stirring mixes it fully, gets the mixed liquor III;
(4) the mixed liquor III that step (3) is obtained is filtered, and packing namely gets the natural antibacterial collutory.
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