KR102638091B1 - Toothpaste composition with whitening function - Google Patents

Abstract

The present invention has the following structure.
In whitening toothpaste using hydrogen peroxide aqueous solution (35% by weight),
It relates to a toothpaste composition with a whitening function containing at least one of sodium percarbonate, colloidal silicon oxide, glycerin, sodium carboxymethyl cellulose, citric acid, and sodium citrate hydrate as a hydrogen peroxide stabilizer to suppress the decomposition of hydrogen peroxide.

Description

Toothpaste composition with whitening function {Toothpaste composition with whitening function}

The present invention relates to a toothpaste composition containing peroxide, and specifically to a toothpaste composition that exhibits excellent whitening action while suppressing the decomposition of hydrogen peroxide.

In general, tooth discoloration factors can be classified into extrinsic discoloration and intrinsic discoloration. Among them, extrinsic tooth discoloration can be caused by food residue, nicotine, coffee, black tea, etc. deposited on the tooth surface, or by staining of tartar or soft deposits on the tooth surface with pigments, while endogenous tooth discoloration can occur when the tooth loses its nerve or is damaged by tetrahydrofury. The cause may be excessive use of cyclin antibiotics or aging phenomenon.

The most commonly encountered dental diseases at the dentist include dental caries (cavities, i.e., a condition in which teeth decay and become dented), periodontitis (rubbed teeth, gum disease), and malalignment, and these are also called the three major dental diseases.

Foods that can cause dental caries include refined foods that do not have a self-cleaning effect (e.g., cookies, cola, hamburgers made from ground meat) and foods with high sugar content (e.g., chocolate, candy, dried fruit) and foods that have high adhesion to the teeth or gums. Examples include foods (snacks) that tend to remain in the urine.

The above-mentioned caries-causing foods stick to the tooth surface and form a bacterial film (plaque), which allows bacteria to multiply, and the acid released from this causes the teeth to decay.

The dental caries rate gradually decreases in the mid-20s and beyond the 30s, and from then on, the rate of periodontitis (gingivitis) increases.

Periodontal disease is the most frequent infectious disease in adults among oral diseases and refers to tooth loss due to gingival bleeding and swelling, formation of periodontal pockets, and destruction of alveolar bone. The mechanism of occurrence of periodontal disease is as follows.

When plaque mechanically accumulates within the periodontal pocket, it becomes a habitat for bacteria existing in the surrounding area, and this habitat gradually transitions from aerobic, breathable Gram-positive bacteria to anaerobic Gram-negative bacteria, and proliferates deep into the periodontal pocket.

At this time, the toxins and all products of the proliferated anaerobic Gram-negative bacteria destroy the tissue directly or stimulate the immune system, causing inflammation and destruction of periodontal tissue through various actions from the stimulated immune system.

It is already well known that the above-mentioned peroxide is effective in whitening teeth, but it has poor compatibility with commonly used toothpaste raw materials and has the problem of reduced stability for long-term storage.

Meanwhile, commonly used toothpaste raw materials contain a large amount of transition metal ions, including iron (III) ions, as impurities, and large amounts of transition metal ions, including iron (III) ions, decompose peroxides, including hydrogen peroxide. Because it acts as a catalyst, peroxide decomposes quickly during storage and distribution, causing gas generation within the product, which has disadvantages such as expansion of the tube or separation of the formulation.

In order to improve the above problems, U.S. Patent No. 5,085,853 describes a special toothpaste container in which gel containing hydrogen peroxide and toothpaste formulation containing sodium bicarbonate are separately filled in a dual-type chamber and come out together from the discharge port when used. , This is to separate and store the active oxygen source from the metal ions that cause activation of the active oxygen source.

However, in this case, the cost of auxiliary materials and facility investment costs for the container are excessive, the volume of the container increases, making it inconvenient to use, and there is a disadvantage that the contents must be double filled when manufacturing toothpaste.

Another method is to encapsulate hydrogen peroxide and put it into toothpaste to prevent reaction with raw materials that are not compatible, and to allow the active ingredients to escape by breaking the capsule due to physical impact when brushing teeth. U.S. Patent No. 4,980,154 describes making capsules of ethylcellulose and apollen wax, known as C-10, and applying coated peroxide to toothpaste prescriptions. However, if the coated material does not decompose quickly in the oral cavity, the effectiveness of peroxide is lost. It has the drawback that it decreases, and it is very difficult to completely encapsulate hydrogen peroxide with current technology, so it cannot be said that aging stability is secured.

Therefore, the purpose of the present invention is to use only raw materials that have proven usability with hydrogen peroxide due to their low content of metal ions, or to improve toothpaste by using abrasives that have poor compatibility but must be used, but have almost no content of metal ions. Another purpose is to provide a whitening toothpaste composition with storage stability, and another purpose is to provide a whitening toothpaste composition that improves both whitening effect and storage stability by adopting peroxide in an appropriate mixing ratio.

Korea Intellectual Property Office Patent Publication No. 10-2000-0007808 (2000.02.07) Korea Intellectual Property Office Patent Registration No. 10-2246287 (2021.04.29) Korea Intellectual Property Office Patent Registration No. 10-2413711 (2022.06.27) Korea Intellectual Property Office Patent Publication No. 10-2014-0128500 (2014.11.06)

The first problem that the invention aims to solve is that the toothpaste composition of the present invention does not emit active oxygen during storage, so it has excellent long-term preservation and continuously maintains the tooth whitening effect.

The second problem that the invention seeks to solve is that peroxide has a sterilizing effect on anaerobic bacteria that cause periodontal disease and a neutralizing effect on acidic substances emitted from plaque, alleviating periodontal disease and keeping gums healthy. is to solve.

The third problem that the invention aims to solve is to solve the problem of keeping the oral cavity clean and refreshing.

The fourth problem that the invention aims to solve is to prevent gingivitis, periodontitis (pyorrhoea) and periodontal disease, and to solve the problem of plaque removal (anti-plaque).

The fifth problem that the invention aims to solve is to solve the problem of phase stability of toothpaste in a tube with a viscosity modifier and binder.

In order to solve the above problems, the following composition is provided.

In the whitening toothpaste using an aqueous hydrogen peroxide solution (35% by weight),

To suppress the decomposition of hydrogen peroxide, a toothpaste composition with a whitening function containing at least one of sodium percarbonate, colloidal silicon oxide, glycerin, sodium carboxymethyl cellulose, citric acid, and sodium citrate hydrate as a hydrogen peroxide stabilizer.

Here, it is preferable that the hydrogen peroxide aqueous solution (35% by weight) and sodium percarbonate are mixed at a weight ratio of 1:1 to 2:1.

Here, it is preferable to further contain povidone (K-29/32) and povidone (K-90) as viscosity regulators.

Here, the weight ratio of the povidone (K-29/32) and the povidone (K-90) is preferably 1:1.

Here, the hydrogen peroxide aqueous solution (35% by weight) preferably contains 0.1 to 10% by weight.

Here, the hydrogen peroxide aqueous solution (35% by weight) is preferably 2.15% by weight.

Here, it is preferable to further include one or more of polyethylene glycol, propylene glycol, and D-sorbitol as a humectant.

Here, the content of the aqueous hydrogen peroxide solution (35% by weight) is 0.1 to 10% by weight based on the total weight of the composition, the sodium percarbonate is 0.1 to 5% by weight, the colloidal silicon oxide is 5 to 25% by weight, and the glycerin is 10 to 25% by weight. By weight, it is preferable that the citric acid is 0.1 to 0.5 weight %, the sodium carboxymethyl cellulose is 0.2 to 10 weight %, and the sodium citrate hydrate is 0.25 to 2.0 weight %.

Here, it is preferable that the sodium citrate hydrate acts as a PH regulator.

Here, it is preferable to further contain sodium bicarbonate as a PH adjuster.

Here, it is preferable to further include a wetting agent, binder, foaming agent, excipient, PH regulator, viscosity regulator, flavoring agent, and herbal medicine.

The first effect of the invention is that the toothpaste composition of the present invention does not emit active oxygen during storage, so it has excellent long-term preservation and continuously maintains the tooth whitening effect.

The second effect of the invention is that peroxide has a sterilizing effect on anaerobic bacteria that cause periodontal disease and a neutralizing effect on acidic substances emitted from plaque, thereby alleviating periodontal disease and keeping gums healthy. .

The third effect of the invention is to keep the oral cavity clean and refresh the oral cavity.

The fourth effect of the invention is to prevent gingivitis, periodontitis (pyorrhoea) and periodontal disease, and also has the effect of removing plaque (anti-plaque).

The fifth effect of the invention is that the phase stability of the toothpaste in the tube is excellent due to the viscosity modifier and binder.

The components of the toothpaste of the present invention are as follows.

The present invention relates to a toothpaste composition, and more specifically, to a toothpaste composition that is significantly effective in whitening teeth, removing plaque, and suppressing periodontal disease.

For the purpose of teeth whitening effect, it contains calcium peroxide (CaO2), which is a peroxide that is easily decomposed by moisture and releases active oxygen, and sodium bicarbonate as essential ingredients for the purpose of suppressing periodontal disease. In these compositions, storage This is to solve the problem that active oxygen is released due to decomposition of peroxide by metal ions such as sodium ions released by moisture and other components in the composition, making it difficult to store for a long time and not providing the desired effect sufficiently.

For this reason, the abrasive is characterized by containing α-alumina trihydrate, which does not emit metal ions, and fumed silica and polyoxyethylene-polyoxypropylene copolymer as a stabilizer as essential ingredients. It relates to a toothpaste composition.

Since the toothpaste composition according to the present invention does not release active oxygen during storage, it has excellent long-term preservation and can continuously provide a tooth whitening effect and periodontal disease suppression effect.

They have a sterilizing effect against anaerobic bacteria that cause periodontal disease.

The toothpaste composition according to the present invention includes abrasives, humectants, foaming agents, binders, fragrances, sweeteners and other ingredients that are common components of ointment.

The humectant is an ingredient that suppresses evaporation of water in the toothpaste composition and prevents it from solidifying when exposed to the air. It is one or two or more types of polyhydric alcohols such as glycerin, sorbitol solution, non-consolidated sorbitol solution, polyethylene glycol, and propylene glycol. You can select and use

The present invention relates to a toothpaste composition having a teeth whitening effect, and more specifically, to a toothpaste composition that contains hydrogen peroxide as a peroxide that releases active oxygen for the purpose of teeth whitening effect,

The toothpaste composition of the present invention does not emit active oxygen during storage, so it has excellent long-term preservation and can continuously provide a teeth whitening effect.

The present invention relates to a toothpaste composition having a teeth whitening effect. More specifically, it contains hydrogen peroxide as a peroxide that releases active oxygen for the purpose of teeth whitening effect, and contains metal ions released by other ingredients in the composition during storage. In order to solve the problem of making it difficult to store for a long time due to the release of active oxygen due to the decomposition of peroxide, etc., and not being able to provide the desired effect sufficiently, a toothpaste composition containing a refined abrasive to suppress the content of metal ions was developed. It's about.

Since the toothpaste composition of the present invention does not emit active oxygen during storage, it has excellent long-term preservation and can continuously provide a tooth whitening effect.

The whitening principle of the present invention is that free radicals created by ionization of the oxidizing agent H ₂ O ₂ , which is hydrogen peroxide, penetrate into the organic matter of enamel, the surface component of the tooth, and dentin, the internal component, and combine with organic substances that cause tooth discoloration to form pigment substances. oxidizes and destroys colored pigments into small, non-pigmented particles, causing bleaching.

Additionally, adding hydrogen peroxide to toothpaste can create oxygen bubbles to help sterilize the inside of the mouth and the surface of the teeth.

It was found that the method using oxygen gave the most appropriate results. Therefore, it was revealed that oxygen with small particles has an excellent sterilizing effect.

The term "foaming agent" used in the present invention improves the feeling of use of the product, helps the cleaning action, speeds the dispersion and penetration of other medicinal ingredients, and reduces interfacial tension to make it easier to remove foreign substances in the oral cavity.

The term “additive” used in the present invention refers to the addition of flavoring agents, sweeteners, pH adjusters, and excipients.

Flavors are edible, and synthetic fragrances such as menthol, green tea flavor, and mint flavor, extracts extracted from plants such as peppermint oil, spearmint oil, sage oil, eucalyptol, and eugenol, and extracts extracted from fruits can be used. .

Saccharin, xylitol, and enzyme-treated stevia are used as sweeteners .

Sodium bicarbonate, etc. can be used as a pH adjuster .

Hydroxyapatite is used as a whitening and excipient .

Food coloring is mainly used as coloring .

The humectant may be one or more selected from the group consisting of glycerin, polyethylene glycol, and propylene glycol.

D-sorbitol is used as a humectant as well as a sweetener.

Green tea extract as a cleanser ,

Dandelion extract as an herbal medicine ,

Purified water

The foaming agent consists of sodium lauryl sulfate and hydrogen peroxide.

Stabilizers include colloidal silicon oxide, glycerin, citric acid, and sodium citrate hydrate .

Sodium carboxymethylcellulose is used as a binder .

As a whitening agent , the toothpaste composition contains at least one peroxide selected from 35% by weight solution of hydrogen peroxide, urea peroxide, calcium peroxide, sodium pyrophosphate, or sodium percarbonate as an aqueous solution of hydrogen peroxide (35% by weight) based on the entire toothpaste composition. ) It is characterized in that it contains 0.1 to 10% by weight based on the physical properties.

Among the peroxides that act as whitening agents in the composition of whitening toothpaste, hydrogen peroxide is strongly acidic at pH 1.8 - 3.5, and is stable when the pH is acidic, but its oxidizing effect is more dominant than whitening action. It is known that whitening action is more dominant than oxidizing action when it is basic, but water It has the disadvantage of being quickly decomposed into hydrogen and hydrogen, making long-term storage difficult. To solve this problem, a stabilizer is added.

Another method is to mix different types of peroxides in an appropriate mixing ratio and add them to the whitening toothpaste composition, which can improve whitening ability while suppressing the decomposition of hydrogen peroxide.

The weight percent of the composition and its uses are summarized in a table as follows.

The whitening toothpaste composition was mainly described as an aqueous hydrogen peroxide solution.

composition weight% Usage Hydrogen peroxide solution (35% by weight) 0.1~10 Whitening sodium percarbonate 0.1~5 stabilizer Colloidal silicon oxide 5~25 Stabilizer, thickener, abrasive glycerin 10~25 Stabilizer, wetting agent citric acid 0.1~0.5 Stabilizers, flavorings, preservatives polyethylene glycol 1.5~3.5 humectant propylene glycol 1.5~2.5 humectant Sodium Carboxymethylcellulose 0.2~10 Binding agent, stabilizer, preservative Enzyme-processed stevia 0.04~0.06 Whitening, sweetener Sodium lauryl sulfate 1.5~3 foaming agent Hydroxyapatite 0.1~18 Whitening agent, excipient Tocophenol Acetate 0.05~30 Prevents cavities, relieves gum disease symptoms Sodium citrate hydrate 0.25~2.0 Stabilizer, PH regulator sodium bicarbonate 0.1~0.5 PH regulator Povidone (K-29/32) 0.2~1.8 Viscosity regulator Povidone (K-90) 0.2~1.8 Viscosity regulator L-Menthol 0.1~2 Spices Licorice extract 0.1~1 Antibacterial, antioxidant, gum and periodontal disease prevention Lemon Extract 0.5~2.5 Fragrance, Antioxidant Vitamin C 0.05~1 Gum disease prevention, antioxidant function Sage Extract 0.1~1.5 Spices aloe extract 0.06~0.15 Plaque removal, anti-cavity, fragrance agent Eucalyptus Extract 0.06~0.1 Spices xylitol 0.05~2 Sweetener, cavity prevention, flavoring agent Chamomile (Matricaria) Extract 0.001~0.5 Antibacterial, anti-inflammatory, pain relief Propolis Extract 0.2~1.0 Fragrance, foaming agent D-Sorbitol 20~30 Sweetener, humectant green tea extract 0.1~1.5 Fragrance, detergent, tooth corrosion prevention, antibacterial, anti-aging Dandelion Extract 1.5~2.5 herbal medicine Purified water balance

Additive 5.15% by weight,

The most preferred embodiment is 2.15% by weight of hydrogen peroxide (35% by weight aqueous solution) .

The currently commercially available hydrogen peroxide aqueous solution uses a 35% by weight aqueous solution, and this solution has strong oxidizing power.

The peroxide content of the present invention may be 0.1 to 10% by weight, specifically 0.5 to 5% by weight, and more specifically 2.15% by weight based on the total weight of the toothpaste composition.

In particular, mixing hydrogen peroxide aqueous solution and sodium percarbonate in a weight ratio of 1:1 to 2:1 suppresses the decomposition of hydrogen peroxide and exhibits excellent whitening effect.

Colloidal silicon oxide (silica) is used as a hydrogen peroxide stabilizer, thickener, and abrasive .

It consists of an aqueous hydrogen peroxide solution and colloidal silicon oxide in a ratio of 1:4 to 1:6, so the long-term preservation of hydrogen peroxide is excellent and this provides a continuous teeth whitening effect.

The first function is that colloidal silicon oxide is used as an anti-caking agent to absorb moisture or prevent solidification.

Second, it is used as a thickener (resistance to liquid-like flow).

Thirdly, it acts as an abrasive.

Instead of using metal oxides, which are mainly abrasives that harm the stability of hydrogen peroxide, silica is used.

The content of the abrasive in the present invention may be 5 to 25% by weight, specifically 8 to 16% by weight, and more specifically 10 to 15% by weight based on the total weight of the toothpaste composition.

The thickener of the present invention acts as a binder in the toothpaste composition and prevents the solid powder component and liquid component from separating. In the present invention, it has excellent compatibility with hydrogen peroxide, has a swelling effect, has an excellent thickening effect even in anhydrous formulations, and has an excellent feeling of use because it is not sticky. In addition, in addition to the function of preventing the separation of toothpaste ingredients, it also affects the appearance of the toothpaste such as retention and transparency, its extrusion from the toothpaste tube, and its use properties such as loosening ability when brushing teeth, as well as efficacy such as drug delivery, etc. It also affects the effect.

Citric acid (citric acid)

In the present invention, citric acid (citric acid/10-2014-0128500 / chemical formula is C ₆ H ₈ O ₇ ) and sodium citrate hydrate are used as hydrogen peroxide stabilizing substances, and it is most preferable to use 0.1 to 0.5% by weight.

Citric acid (English: citric acid) is a weak organic acid mainly found in citrus fruits, and its chemical formula is C ₆ H ₈ O ₇ .

In the present invention, citric acid is used as a flavoring agent, acidifying agent, and preservative.

Citric acid is a natural preservative.

glycerin

Additionally, in the present invention , glycerin is used to suppress the activation of oxygen sources to stabilize hydrogen peroxide.

Glycerin is used in an amount of 10 to 25% by weight based on the total weight of toothpaste. More preferably, 17% by weight of glycerin is preferred.

The molecular formula is C ₃ H ₅ (OH) ₃ . Because it has a sweet taste, it is also classified as a sugar alcohol.

Therefore, it can be manufactured through hydrolysis of neutral fat under a base catalyst as shown in the picture above, and this is called a saponification reaction.

Glycerin is also used as a humectant.

In addition, it is preferable to contain 1.5 to 3.5% by weight and 1.5 to 2.5% by weight of polyethylene glycol and/or propylene glycol as a humectant, respectively.

More preferably, it is desirable to contain 2% by weight of polyethylene glycol and 1.8% by weight of propylene glycol.

Sodium Carboxymethylcellulose

The sodium carboxymethyl cellulose is a polymer material that stabilizes hydrogen peroxide and is used in an amount of 0.2 to 10% by weight in the present invention.

It is also used as a binder.

The use of a binder in toothpaste is essential in ointment-type toothpaste as it prevents the solid powder component and liquid component from separating, and any type of water-soluble polymer can be used. Sodium carboxymethylcellulose synthesized from tree cellulose is used.

The binder is a component that prevents phase separation over time by combining the water-insoluble inorganic powder component and the liquid component in the toothpaste composition and provides viscosity to the composition, including sodium carboxymethyl cellulose, carrageenan, xanthan gum, and polyvinyl pyrroli. Money, sodium alginate, and other gums can be used.

When dissolved in water, it becomes a sticky liquid and has properties that prevent mold and rot, so it can be stored for a long time. It is also mixed into detergents to increase cleaning effectiveness.

Sodium citrate hydrate

Sodium citrate hydrate is used as a stabilizer, solubility aid, and pH adjuster.

It is preferable to use 0.25 to 2.0% by weight.

Sodium citrate hydrate is A method for masking the salty taste of an oral composition is provided.

sodium bicarbonate

Sodium bicarbonate is used as a pH adjuster. A toothpaste composition containing sodium bicarbonate is effective in suppressing the formation of bacterial film on the teeth and showing a gingivitis alleviating effect.

Contains tocopherol acetate.

The tocopherol acetate (vitamin E) is used as an ingredient in toothpaste, and an increase of 30% was used. In particular, in the present invention, by using tocopherol acetate, there is almost no irritation in the oral cavity when using toothpaste, it does not cause dryness in the oral cavity even after use, and bad breath caused by various causes can be quickly and effectively removed, and the taste and scent are pleasant to the user. It was found that it is not unpleasant to the skin, foams sufficiently when used, and has the advantage of reducing dryness in the mouth after use.

Tocopherol acetate produces collagen in the gums to help heal wounds in the gums, and helps hemostasis by activating proteolytic enzymes that coagulate blood.

Tocopherol acetate included in the toothpaste composition of the present invention contributes to alleviating gum disease symptoms such as gum inflammation, swelling, pain, and bleeding, and further contributes to preventing cavities and gum disease.

Tocopherol acetate has an antioxidant effect on gum tissue and prevents cavities.

Tocopherol has an antioxidant effect and acts to prevent oxidation of vitamin A in vivo. It is also known to have a periodontitis prevention effect.

The content of tocopherol acetate in the toothpaste composition is based on the total weight of the toothpaste composition.

As a standard, it has a content of 0.05 to 30% by weight.

Contains flavoring agents and other additives

Propolis extract causes little oral irritation when used, does not cause oral dryness after use, can quickly and effectively remove bad breath caused by various causes, has no objection to use due to its taste and scent, and foams when used. It was found that it was sufficient and had the advantage of reducing dryness in the mouth after use.

It is preferable to add 0.2 to 1.0% by weight out of 100% by weight of the toothpaste preservative composition.

Propolis extract has gum strengthening and anti-inflammatory effects. By being included in the toothpaste composition of the present disclosure, the propolis extract contributes to the prevention of cavities, gingivitis, and periodontitis, and further contributes to additional effects such as plaque removal, whitening effect, and bad breath removal.

Sage extract has antiseptic, antibacterial, and anti-inflammatory functions.

It is preferable to add 0.1 to 1.5 weight%.

Ginseng extract, propolis extract, oyster oil, L-menthol, columbine flavor, and combined flavor (apple flavor) can be used alone or in combination.

L-menthol is used in an amount of 0.1 to 2% by weight of the toothpaste composition.

Additionally, the L-menthol is added to remove bad breath.

It not only provides a refreshing feeling in the mouth due to its unique refreshing taste, but also has an excellent function of removing bad breath. Therefore, if the amount of L-menthol added is less than 0.1% by weight, there is a risk of weakening the bad breath removal function like peppermint oil, and on the other hand, if it exceeds 2% by weight, it may cause discomfort due to strong irritation, and also weakens the efficacy of the ingredients added together. There is a risk that it will be done.

It has the chemical formula C ₁₀ H ₂₀ and is a colorless rod-shaped or needle-shaped crystal or white crystalline powder.

It has a unique and refreshing smell, and although it tastes slightly bitter at first, it has a refreshing taste.

It may be one selected from the group consisting of grapefruit seed extract, Matricaria extract, aloe extract, eucalyptus extract, sage extract, xylitol, ascorbic acid (vitamin C), sodium cocoyl glutamate, and combinations thereof.

In addition, Matricaria extract is extracted from chamomile flowers, has anti-allergic and anti-allergic properties and helps relieve irritation caused by toothpaste to the user. Additionally, aloe extract extracted from aloe leaves has antibacterial, antiviral, analgesic, wound healing, and anti-inflammatory functions.

Eucalyptus extract has the function of preventing cavities and gum disease, and is used in an amount of 0.06 to 0.1% by weight.

Additionally, xylitol contributes to preventing cavities,

Ascorbic acid, vitamin C, prevents gum disease and has antioxidant properties.

D-sorbitle solution is used as a humectant and sweetener .

Use 20-30% by weight of the total weight of toothpaste.

green tea extract

Contains 0.1 to 1.5% by weight.

It prevents tooth decay caused by caries bacteria and is effective in relieving bad breath.

Green tea extract has an excellent anti-inflammatory effect that suppresses swelling in inflamed areas and an antibacterial effect against various bacteria. It also has an excellent cell protection effect, so it has an excellent anti-aging effect on the skin.

count The tablet uses yucca or green tea extract.

The green tea extract is added to have oral cleaning, anti-plaque, and cavity prevention functions. Flavonoids, which are abundant in green tea, coat the tooth surface and protect it from acids. In addition, the catechin component of green tea inhibits the growth of cavity-causing bacteria that cause cavities and inhibits the activity of substances that cause tartar formation. In addition to this cavity prevention effect, it is also effective in removing bad breath, preventing tooth discoloration, and bad breath. Therefore, if the amount of green tea extract added is less than 0.1% by weight, there is a risk of weakening the oral cleaning function, and conversely, if it exceeds 1.5% by weight, there is a risk of weakening the effectiveness of the ingredients added together. For this reason, 0.1 to 1.5% by weight is preferable.

Enzyme-processed stevia

Use 0.04~0.06% by weight.

Enzyme-treated stevia has a teeth-whitening effect, and U.S. Patent No. 4,986,981 uses vegetable proteolytic enzymes instead of peroxide.

The present invention adds the function of enzyme-treated stevia to an aqueous hydrogen peroxide solution.

Therefore, the whitening performance was further improved.

Enzymes are used to sterilize oral bacteria and suppress and remove plaque.

In the present invention, by using enzyme-treated stevia as a sweetener, there is almost no irritation in the oral cavity when using toothpaste, it does not cause dryness in the oral cavity even after use, and bad breath caused by various causes can be quickly and effectively removed, and the taste and scent are reduced. It was discovered that there is no resistance to using it, that there is sufficient foam when used, and that it has the advantage of reducing dryness in the mouth after use.

Hydroxyapatite

In the present invention, 0.1 to 18% by weight is used in the entire toothpaste composition.

In particular, hydroxyapatite, which has been known to be effective for hypersensitive teeth by filling the crown of dentin exposed from damaged teeth, has recently been effective in whitening.

In other words, hydroxyapatite is the main component of human bones and teeth, and in particular, hydroxyapatite accounts for about 97% of the enamel layer, the outer surface of teeth.

Therefore, using this fine powder of hydroxyapatite has the characteristic of whitening the tooth surface by filling the damaged and roughened tooth surface with an adsorption effect.

In the present invention, the hardness of the tooth surface is increased and there is a whitening effect.

Hydroxyapatite is the main substance that makes up tooth enamel and dentin.

Hydroxyapatite is found in teeth and bones throughout the body. Therefore, it is commonly used as a filler to replace cut bone or as a coating agent to promote bone ingrowth toward artificial implants.

Many modern implants, such as dental implants and bone conduction implants, are coated with hydroxyapatite. This increases osseointegration.

It is also used to treat early lesions of tooth enamel .

In particular, hydroxyapatite, which has been known to be effective for hypersensitive teeth by filling the crown of exposed dentin from damaged teeth, has recently been known to be effective in whitening, and many related studies are being conducted. Using this fine powder of hydroxyapatite has the characteristic of whitening the surface of a tooth by filling it with an adsorption effect on the damaged and roughened tooth surface.

In addition, in order to improve the feeling of use of the toothpaste composition according to the present invention, flavorings, sweeteners, colorants, etc. can be used, and the use of edible flavorings is essential as a flavoring agent used for this purpose.

aloe extract

Use 0.06 to 0.1% by weight of aloe extract.

The aloe extract has antioxidant activity, antibacterial activity, anti-tumor activity, bactericidal activity, anti-inflammatory activity, tissue formation activity, etc.

Licorice extract

Licorice extract is used as a flavoring agent in toothpaste.

Use 0.1 to 1% by weight .

The licorice extract, like phytoncide, is added to prevent gum disease and periodontal disease. Glycyrrhizin, the main component of licorice, has anti-inflammatory, antibacterial, and antiviral effects, polyphenol has anticancer properties, and glabridin is an antioxidant and melanin agent. It functions to suppress production.

Therefore, if the amount of licorice extract added is less than 0.1% by weight, there is a risk of weakening the gum disease and periodontal disease prevention function such as phytoncide. Conversely, if it exceeds 1% by weight, the manufacturing cost will increase and the efficacy of other raw materials added together may be weakened. There are concerns. For this reason, 0.1 to 1% by weight is preferable.

Purified water consists of the remaining weight percent.

Purified water (or ultrapure water) is water from which all impurities such as dissolved ions, solid particles, microorganisms, organic matter, and dissolved gases contained in water have been removed.

Sodium lauryl sulfate

Sodium lauryl sulfate is used as a foaming agent and contains 1.5 to 3% by weight.

Sodium lauryl sulfate (~黃酸~). Anionic surfactant. White or light yellow crystals. Wetting agent, emulsifying aid, various beauty and skin cleansing agents. Used as an ingredient in cream toothpaste.

It has the property of generating bubbles when dissolved in water and shaken.

Used as a foaming agent.

The use of foaming agents improves the feeling of use of the product, aids the cleaning action, speeds the dispersion and penetration of other medicinal ingredients, and reduces interfacial tension, making it easier to remove foreign substances from the oral cavity. Sodium lauryl sulfate, an anionic surfactant, is mainly used as a foaming agent, and depending on the characteristics of the formulation, auxiliary nonionic surfactants such as polyoxyethylene polyoxypropylene copolymer (floxamer), polyoxyethylene hydrogenated castor oil, and polyoxyethylene are used as foaming agents. Oxyethylene sorbitan fatty acid ester, etc. are used.

The use of foaming agents improves the feeling of use of the product, aids the cleaning action, speeds the dispersion and penetration of other medicinal ingredients, and reduces interfacial tension, making it easier to remove foreign substances from the oral cavity. Sodium lauryl sulfate, an anionic surfactant, is mainly used as a foaming agent, and depending on the characteristics of the formulation, auxiliary nonionic surfactants such as polyoxyethylene polyoxypropylene copolymer (floxamer), polyoxyethylene hydrogenated castor oil, and polyoxyethylene are used as foaming agents. Oxyethylene sorbitan fatty acid ester, etc. are used.

Lemon Extract

It has 0.5 to 2.5% by weight.

If the lemon extract is contained in less than 0.5% by weight, palatability is reduced, and if it is contained in excess of 5% by weight, the lemon scent becomes too strong.

It is rich in vitamins, minerals, phosphorus, and dietary fiber. In particular, it is rich in liminoid, an antioxidant, which helps suppress free radicals and aging.

It also helps improve blood circulation and immunity. That is why it is often used as a detox product. It is also rich in vitamin C and is good for fatigue recovery and skin.

Lemon juice contains a lot of citric acid, so it is acidic, has a strong sour taste, and has a pH of about 2 to 3.

Vitamin C

As a nutritional supplement, it contains vitamin C.

Vitamin C consists of 0.05 to 1% by weight. It is harmless to the human body and has good effects on the gums.

Vitamin C, or ascorbic acid, is one of the water-soluble vitamins and is used as a coenzyme for collagen synthesis and intracellular energy metabolism, and is a powerful reducing agent with antioxidant properties. It is included in almost all animals and plant groups, but among mammals, apes such as humans and chimpanzees cannot synthesize it in the body and must ingest it from outside.

Today, it has been revealed that the reason vitamin C prevents scurvy is because it is an essential nutrient that participates in the synthesis of collagen and forms connective tissue.

The molecular formula is C ₆ H ₈ O ₆ .

Pure vitamin C is in the form of a colorless powder and has a unique, pungent, sour odor.

xylitol

A natural sweetener that does not form acids that cause cavities. For reference, xylitol, along with vitamin D and calcium, is a health functional food that has been scientifically proven to prevent diseases, and has the highest disease risk reduction grade among them.

The chemical formula is (CHOH) ₃ (CH ₂ OH) ₂ . It is one of the sugar alcohols.

Used as a sweetener.

Xylitol is an ingredient that is very helpful for oral health.

The cause of tooth decay is mutans, a caries-causing bacterium. Mutans is a bacteria found only in humans and not in animals. It causes cavities through the process of converting sugar into acid in the mouth and dissolving the surface of the teeth. Xylitol is the only natural material that has the ability to inhibit the reproduction of mutans bacteria and reduce their population.

It has a good taste and aroma and also acts as a sweetener and flavoring agent .

Chamomile Extract

Chamomile extract is also called Matricaria extract.

In the present invention, the chamomile extract has 0.001 to 0.5% by weight.

Rosemary, chamomile, and jasmine are all herbs that are excellent for removing bad breath and providing a refreshing feeling, and each has different strengths.

Rosemary helps with skin care and also has the property of relieving depression. The scent is not strong, so even people who dislike herbs can use it.

Also, the unique scent helps clear your head.

It is effective for pain and inflammation.

Povidone (K-29/32)

Povidone, also known as polyvinylpyrrolidone, is a synthetic polymer used as a binding and stabilizing agent.

Used as a viscosity modifier.

It contains a content of 0.2 to 1.8% by weight.

It is a diverse class of compounds with varying molecular weights, with Povidone K-29/32 being one specific class within the povidone family.

Povidone K-29/32 is a specific type of PVP with a relatively low average molecular weight, falling within the molecular weight range between 29,000 and 32,000 grams/mole.

This molecular weight range is suitable for a variety of applications because it has balanced properties in a variety of applications.

Povidone K-29/32 is frequently used in the pharmaceutical industry as a binder, disintegrator and solubility enhancer in the manufacture of tablets and capsules. As a binder, it helps keep the tablet intact by holding the drug and additional ingredients together.

It is used in topical formulations such as creams, gels, and ointments.

Povidone (K-90)

Povidone K-90 is another class of the povidone family and has a higher molecular weight. This grade has different properties and applications due to its higher molecular weight compared to povidone K-29/32.

Povidone K-90 has stronger binding and film forming properties due to its higher molecular weight.

Used as a viscosity modifier.

Contains a content of 0.2 to 1.8% by weight.

Povidone K-29/32:Povidone (K-90) works best as a viscosity regulator when the ratio is 1:1.

Povidone (K-29/32), Povidone (K-90): Hydrophilic colloid 0.2 to 1.8% by weight must be used to achieve the desired viscosity.

Propolis Extract

It is one of the by-products of beekeeping produced by bees, and is a mixture of resinous substances that bees collect from plants such as tree buds and sap. It is different from royal jelly. In Chinese, it is called Bongyo (蜂膠).

As a domestic standard, the Ministry of Food and Drug Safety recognizes functionality only for antioxidant activity and oral antibacterial activity.

Mainly known effects include antioxidant, antibacterial, antiviral, antifungal, herpes, antiprotozoan, antitumor, and anti-inflammatory effects. It has anti-inflammatory, hepatoprotective, and antidiabetic effects.

In general, it has an antibiotic effect, so it helps improve inflammatory symptoms.

Adding a few drops to water and gargling will help relieve soreness and reduce bad breath. Instead, it smells like propolis.

It also acts as a foaming agent.

It is preferably contained at 0.2 to 1.0% by weight.

Experimental Example 1 Measurement of stability of toothpaste

(1) Method for measuring high temperature stability of hydrogen peroxide

A titration method using iodine, an indirect method of measuring hydrogen peroxide concentration, measures the hydrogen peroxide concentration of toothpaste at the beginning of manufacture and the hydrogen peroxide concentration of toothpaste after storing it in a tube in a constant temperature water bath at 40°C for 4 weeks, and measures the remaining hydrogen peroxide compared to the initial manufacture. The concentration ratio was calculated. If no decomposition occurred at all, it was expressed as 100%.

The temperature was calculated as 40°C because it was judged that the above temperature would not normally be exceeded when stored at room temperature.

Example 1

composition weight% note Hydrogen peroxide solution (35% by weight) 2.15 sodium percarbonate 2.15 Colloidal silicon oxide 8 glycerin 10 citric acid 0.3 polyethylene glycol 2 propylene glycol 1.8 Sodium Carboxymethylcellulose 6 Enzyme-processed stevia 0.05 Sodium lauryl sulfate 2 Hydroxyapatite 5 Tocophenol Acetate 5 Sodium citrate hydrate 1.5 Povidone (K-29/32) 1.2 Povidone (K-90) 1.2 L-Menthol One Licorice extract 0.8 Lemon Extract One Vitamin C 0.5 Sage Extract One aloe extract 0.1 Eucalyptus Extract 0.08 xylitol One Chamomile (Matricaria) Extract 0.3 Propolis Extract 0.8 D-Sorbitol 20 green tea extract One Dandelion Extract 2 Purified water balance

Example 2

In Example 2, sodium bicarbonate, a PH regulator, was added, the weight percent of colloidal silicon oxide was increased, and the glycerin content was reduced.

Additionally, the ratio of hydrogen peroxide aqueous solution and sodium percarbonate was adjusted.

composition weight% note Hydrogen peroxide solution (35% by weight) 2.15 sodium percarbonate One Colloidal silicon oxide 13 glycerin 5 citric acid 0.3 polyethylene glycol 2 propylene glycol 1.8 Sodium Carboxymethylcellulose 6 Enzyme-processed stevia 0.05 Sodium lauryl sulfate 2 Hydroxyapatite 5 Tocophenol Acetate 15 Sodium citrate hydrate 1.5 sodium bicarbonate 0.3 Povidone (K-29/32) 1.2 Povidone (K-90) 1.2 L-Menthol One Licorice extract 0.8 Lemon Extract One Vitamin C 0.5 Sage Extract One aloe extract 0.1 Eucalyptus Extract 0.08 xylitol One Chamomile (Matricaria) Extract 0.3 Propolis Extract 0.8 D-Sorbitol 20 green tea extract One Dandelion Extract 2 Dandelion Extract balance

Example 3

Compared to Example 2, the ratio of aqueous hydrogen peroxide solution and sodium percarbonate was 1:1, and the weight percent of glycerin was increased.

composition weight% note Hydrogen peroxide solution (35% by weight) 2.15 sodium percarbonate 2.15 Colloidal silicon oxide 13 glycerin 10 citric acid 0.3 polyethylene glycol 2 propylene glycol 1.8 Sodium Carboxymethylcellulose 6 Enzyme-processed stevia 0.05 Sodium lauryl sulfate 2 Hydroxyapatite 5 Tocophenol Acetate 15 Sodium citrate hydrate 1.5 sodium bicarbonate 0.3 Povidone (K-29/32) 1.2 Povidone (K-90) 1.2 L-Menthol One Licorice extract 0.8 Lemon Extract One Vitamin C 0.5 Sage Extract One aloe extract 0.1 Eucalyptus Extract 0.08 xylitol One Chamomile (Matricaria) Extract 0.3 Propolis Extract 0.8 D-Sorbitol 20 green tea extract One Dandelion Extract 2 Dandelion Extract balance

(2) Method for measuring phase stability of toothpaste at high temperature

After storing the tube in a constant temperature water bath at 40°C for 4 weeks, check whether the toothpaste is separated when the toothpaste is squeezed, and check the surface condition when the toothpaste tube is cut in half to check whether the contents adhere well to the tube. was observed with the naked eye.

Toothpaste stability measurement results

The results of measuring the high-temperature stability of the hydrogen peroxide and the phase stability of the toothpaste at high temperatures for each of the toothpaste compositions of Examples 1 to 3, 7, and 8 and Comparative Examples 1 to 5 are shown in Table 3 below.

Store at 40℃ Example 1 Example 2 Example 3 Residual peroxide ratio after 4 weeks 96% 97% 96% Toothpaste stability in tube after 4 weeks stability stability stability

Phase separation did not occur, and the residual peroxide ratio was constant and good after 4 weeks.

As the specific parts of the present invention have been described in detail above, it is clear to those skilled in the art that these specific techniques are merely preferred embodiments and do not limit the scope of the present invention. will be. Accordingly, the actual scope of the present invention will be defined by the claims and their equivalents.

Claims (11)

In a toothpaste composition with whitening function using an aqueous hydrogen peroxide solution (35% by weight),
The hydrogen peroxide aqueous solution (35% by weight) contains 0.1 to 10% by weight,
The hydrogen peroxide aqueous solution (35% by weight) and sodium percarbonate are mixed in a weight ratio of 1:1 to 2:1,
In order to suppress the decomposition of hydrogen peroxide in the aqueous hydrogen peroxide solution, sodium percarbonate, colloidal silicon oxide, glycerin, sodium carboxymethyl cellulose, citric acid, and sodium citrate hydrate are included as hydrogen peroxide stabilizers,
It further contains povidone (K-29/32) and povidone (K-90) as viscosity modifiers.
A toothpaste composition with whitening function, characterized in that the weight ratio of the povidone (K-29/32) and the povidone (K-90) is 1:1. delete delete delete delete The toothpaste composition according to claim 1, wherein the aqueous hydrogen peroxide solution (35% by weight) is 2.15% by weight. The toothpaste composition according to claim 1, further comprising at least one of polyethylene glycol, propylene glycol, and D-sorbitol as a humectant. The method of claim 1, wherein the content of the aqueous hydrogen peroxide solution (35% by weight) is 0.1 to 10% by weight based on the total weight of the composition, the sodium percarbonate is 0.1 to 5% by weight, the colloidal silicon oxide is 5 to 25% by weight, and the glycerin. A toothpaste composition with a whitening function comprising 10 to 25% by weight of silver, 0.1 to 0.5% by weight of citric acid, 0.2 to 10% by weight of sodium carboxymethyl cellulose, and 0.25 to 2.0% by weight of sodium citrate hydrate. delete The toothpaste composition with whitening function according to claim 1, further comprising sodium bicarbonate as a PH regulator.



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