KR102413711B1 - A toothpaste composition comprising hydrogen peroxide and a thickener in separate form - Google Patents

Abstract

The present invention relates to a toothpaste composition comprising a peroxide, a thickening agent and a spreading agent, and in particular, the peroxide and the thickening agent are each in a separate form, and specifically, the feeling of use, stability and whitening effect even in an anhydrous state relates to an excellent toothpaste composition.

Description

A toothpaste composition comprising hydrogen peroxide and a thickener in separate form

The present invention relates to a toothpaste composition comprising a peroxide, a thickening agent and a spreading agent, and in particular, the peroxide and the thickening agent are each in a separate form. It relates to an excellent toothpaste composition.

In the case of toothpaste, since it contains foaming agents, abrasives, and active ingredients, its basic properties are to provide cleaning power and refreshing feeling when used with a toothbrush. It is known that the cause of yellowing of teeth is that the coloring material penetrates to the inner surface of the tooth and is difficult to solve other than chemical bleaching by hydrogen peroxide.

In general, consumers want to achieve a whitening effect only by brushing their teeth every day as a convenient method. The whitening toothpaste should be capable of breaking the double bond of the coloring component by penetrating the whitening component to the dentin.

However, hydrogen peroxide has high reactivity with water, so it is easily decomposed in water and has poor compatibility with other components of toothpaste such as polymers, abrasives, fluorine, and foaming agents. In particular, toothpaste containing hydrogen peroxide has a disadvantage in that it cannot create a synergistic effect of these two mechanisms for whitening effect because an abrasive cannot be added together. Therefore, toothpaste containing water as a solvent and a large amount of hydrogen peroxide and high viscosity suitable for tube toothpaste, fluorine, foaming agent, abrasive, fragrance, etc., has poor stability over high temperature of peroxide, and is difficult to commercialize due to phase separation of hydrogen peroxide there was

Accordingly, the present inventors have studied to solve the problems of the prior art. As a result, in the case of a toothpaste composition comprising a peroxide, a thickener and a spreading agent, in particular, the peroxide and the thickening agent are in a separate form, The present invention has been completed by confirming that a toothpaste composition having both excellent feeling and whitening effect can be prepared even when a foaming agent, abrasive, etc. having high compatibility with hydrogen peroxide is used in the anhydrous base.

One object of the present invention is to provide a dentifrice composition comprising a peroxide, a thickening agent and a spreading agent.

Still another object of the present invention is to provide a toothpaste composition comprising the peroxide and the thickener in separate forms.

Hereinafter, the present invention will be described in more detail.

On the other hand, each description and embodiment disclosed herein may also be applied to each other description and embodiment. That is, all combinations of the various elements disclosed herein are within the scope of the present invention. In addition, it cannot be said that the scope of the present invention is limited by the specific descriptions described below.

In addition, those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. Also, such equivalents are intended to be encompassed by the present invention.

As one aspect of the present invention for solving the above problems, the present invention includes a peroxide, a thickening agent and a spreading agent (spreading agent).

When the peroxide, thickener and spreading agent of the present invention are included, the phase stability of the toothpaste composition can be maintained even when supported in a toothpaste container made of, for example, a hydrophobic material such as PE.

Specifically, the toothpaste composition of the present invention provides a toothpaste composition in which the peroxide and the thickener are each in a separate form.

In particular, even when the peroxide and the thickener are included in the toothpaste composition in separate forms, the phase stability of the toothpaste composition is maintained, the activity of hydrogen peroxide is not reduced, and conventional PVP and hydrogen peroxide are included in the form of a complex The release rate of hydrogen peroxide is significantly higher than that of the toothpaste composition, which has a better whitening effect.

As used in the present invention, the term "spreading agent" is used to solve the problem of desorption and phase separation from polyethylene (PE) in the toothpaste tube by making the toothpaste composition appear hydrophobic, thereby improving the phase stability of the toothpaste composition. This means that it is a safe material for the human body. The toothpaste composition of the present invention using a spreading agent is in close contact with the toothpaste tube material, and the water generated by superhydrolysis does not exist between the toothpaste and the tube, thereby suppressing the phase separation phenomenon, thereby remarkably improving the stability of the toothpaste.

The spreading agent in the present invention is Span 20 (Span 20, sorbitan monolaurate), Span 40 (Span 40, sorbitan monopalmitate), Span 60 (Span 60, sorbitan monostearate), Span 80 (Span 80; sorbitan monooleate) ), span 85 (Span 85, sorbitan trioleate), and TWEEN (POE sorbitan fatty acid ester) may be at least one component selected from the group consisting of, specifically, span 80 (Span 80; sorbitan monooleate), span 60 (Span) 60, sorbitan monostearate) or a combination thereof, but is not limited thereto.

The content of the spreading agent in the present invention may be 0.1 to 10% by weight, specifically 0.2 to 5% by weight, more specifically 0.2 to 2.5% by weight based on the total weight of the toothpaste composition. %, but is not limited thereto.

The thickener of the present invention serves as a binder in the toothpaste composition, and functions to prevent the solid powder component from being separated from the liquid component. In the present invention, in particular, it has excellent compatibility with hydrogen peroxide, has a swelling effect, so it has an excellent thickening effect even in anhydrous prescription, and there is no stickiness, so it is excellent in use. In addition, in addition to the function of preventing the separation of the toothpaste components, it affects the appearance of toothpaste such as shape retention and transparency, extrudability from the toothpaste tube, and the use properties such as loosening properties during brushing. It also affects the effect.

In addition, when the thickener forms a complex with hydrogen peroxide, the hydrogen peroxide formulated in the toothpaste composition is physically separated from other toothpaste compounding components such as water, abrasives, foaming agents, and toothpaste effective ingredients, thereby preventing the decomposition of hydrogen peroxide It is known that the problem that the titer of hydrogen peroxide decreases during distribution of the toothpaste composition can be prevented. However, since the complex form of the thickener-hydrogen peroxide acts as an impeding factor in exerting the activity of hydrogen peroxide at the point of use of the actual consumer, it is necessary to pre-treat or post-treat a composition containing a separate hydrogen peroxide decomposing agent.

The thickener of the present invention is specifically polyvinylpyrrolidone (PVP), crosslinked PVP, polyvinyl alcohol (polyvinyl alcohol, PVA), carboxy methyl cellulose (CMC), polyethylene glycol ( poly ethylene glycol, PEG), carboxypolymethylene, Carboxypropyl cellulose, Poloxamer, Carrageenan, Carboxyvinyl polymers, Xanthan gum, Polyvinylpyrrolidone-vinyl acetate copolymer (polyvinyl pyrrolidone/vinyl acetate copolymer), may be one or more components selected from the group consisting of, more specifically PVP, may be crosslinked PVP, but is not limited thereto.

The content of the thickener of the present invention may be 5 to 20% by weight, specifically 7 to 17, and more specifically 10 to 15% by weight, based on the total weight of the toothpaste composition, but is limited thereto it is not

The peroxide of the present invention has a tooth whitening effect while oxygen produced during decomposition bleaches the colored material on the teeth, and has a relatively small molecular weight, so it is effective because of its high tooth whitening power at the same weight.

The peroxides of the present invention are specifically hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium percarbonate, sodium perborate, and tetrasodium pyrophosphate. peroxidate) may be one or more components selected from the group consisting of, and more specifically, hydrogen peroxide, but is not limited thereto.

The content of the peroxide of the present invention may be 0.1 to 10% by weight, specifically 0.5 to 5% by weight, and more specifically 3% by weight, based on the total weight of the toothpaste composition, but is limited thereto not.

The toothpaste composition of the present invention may further include an abrasive.

The abrasive in the present invention refers to a material that polishes the surface of teeth to wipe off plaque, and the peroxide and the abrasive have poor compatibility, so the conventional toothpaste composition could not use the peroxide and the abrasive together, The toothpaste composition of the present invention may include both a peroxide and an abrasive, thereby creating a synergistic effect to cause an excellent whitening effect.

The abrasive in the present invention may be at least one component selected from the group consisting of CPP (calcium pyrophosphate), calcium carbonate, insoluble sodium metaphosphate, zirconium silicate and hydroxyapatite, and specifically, the stable activity of peroxide in the toothpaste composition It may be a CPP in terms of maintenance, but is not limited thereto.

The content of the abrasive in the present invention may be 5 to 20% by weight, specifically 7 to 17% by weight, and more specifically 10 to 15% by weight, based on the total weight of the toothpaste composition, but It is not limited.

The toothpaste composition in the present invention may contain substantially no water. In the present specification, substantially free of water may be 0.01 to 10% by weight, or 0.01 to 8% by weight, specifically 0.01 to 6% by weight, or 0.01 to 5% by weight, based on the total weight of the composition, , more specifically 0.01 to 3% by weight, or 0.01 to 2% by weight, and most preferably means no water at all, but is not limited thereto.

The toothpaste composition of the present invention may have a viscosity of 60,000 to 150,000 cP, specifically 70,000 to 150,000 cP, or more preferably 80,000 to 150,000 cP, more specifically 90,000 to 150,000 cP, but is not limited thereto, and according to the above viscosity, the toothpaste composition of the present invention has excellent feeling of use, such as freshness, cleaning feeling, foaminess and fragrance emitting power. At this time, the viscosity of the toothpaste was measured at room temperature and the viscosity of the toothpaste itself was measured with a Brookfield viscometer at a speed of 20 rpm using an RV07 spindle.

The toothpaste composition of the present invention may be for teeth whitening.

Specifically, in the case of a toothpaste composition comprising a peroxide, a thickener and a spreading agent of the present invention, wherein the peroxide and the thickening agent are each in a separate form, in actual use, the complex (complex) by remarkably rapid decomposition of hydrogen peroxide ) in the form of a thickener and a conventional toothpaste composition containing hydrogen peroxide, it can exhibit a more excellent tooth whitening effect.

The toothpaste composition of the present invention has improved phase stability even at 30 to 60 ° C. Specifically, the phase separation of the peroxide does not occur even after 4 weeks, and the toothpaste composition is in close contact with the tube and there is no water produced by perhydrolysis therebetween. By suppressing the phase separation phenomenon, the toothpaste stability is remarkably improved even in the case of a toothpaste composition comprising the peroxide, thickener and spreading agent of the present invention, wherein the peroxide and thickener are each in a separate form do.

The toothpaste composition of the present invention may further include one or more components selected from the group consisting of surfactants, wetting agents, medicinal agents, additives and foaming agents, but is not limited thereto.

The term "surfactant" used in the present invention improves the compatibility and cleaning action of the oral composition, and facilitates the dispersion and penetration of the active ingredient to easily remove foreign substances from the oral cavity.

In the present invention, as the surfactant, an anionic surfactant and a nonionic surfactant may be used alone or in combination. Preferably, the surfactant is at least one anionic surfactant selected from the group consisting of sodium lauryl sulfate and sodium alkyl sulfate; and polyoxyethylene, polyoxypropylene copolymer, polyoxyethylene sorbitan fatty acid, alkanolamide fatty acid ester, sucrose fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene fatty acid ester, polyoxyethylene hydrogenated castor oil derivative, At least one nonionic surfactant selected from the group consisting of N-lauryl sarcosinate, sodium lauryl ether sulfate, polysorbate, decaglycerin monolaurenite, sorbitan monooleate, alkyl polyglucoside and cocoamide DA It may be at least one selected from the group consisting of.

The term "humectant" used in the present invention is a base ingredient essential for making an ointment-like formulation, and when the oral composition is exposed to air, it prevents drying and solidification and provides gloss to the surface of the toothpaste, and depending on the type, brushing teeth It refers to a substance that plays a role in giving a sweetening effect.

In the present invention, the wetting agent may be at least one selected from the group consisting of sorbitol solution, glycerin, polyethylene glycol and propylene glycol.

The term "medicinal agent" used in the present invention is a substance that can exhibit various medicinal effects for cleaning and cleaning teeth, and includes various functional ingredients and oriental medicine materials that can be included in toothpaste, specifically, fluoride in teeth. It forms a film and may contain fluorides that make acid resistant to acids (lactic acid, etc.) that are metabolites of caries bacteria.

The term "foaming agent" used in the present invention enhances the feeling of use of the product and helps the cleaning action, facilitates the dispersion and penetration of other active ingredients, and reduces the interfacial tension, thereby making it easier to remove foreign substances in the oral cavity.

The term "additive" used in the present invention may include a flavoring agent, a sweetener, a pH adjusting agent, a brightener, an excipient, a preservative, and a color, and the content is used within a conventional range.

The fragrance is edible, and synthetic fragrances such as menthol, green tea fragrance and mint fragrance, extracts extracted from plants such as peppermint oil, spearmint oil, sage oil, eucalyptol, and eugenol, and extracts extracted from fruits may be used. .

As a sweetener, sodium saccharin, xylitol, etc. are most often used, and sodium bicarbonate may be used as a pH adjusting agent, and titanium oxide may be used as a brightening agent. In addition, hydroxyapatite may be used as an excipient, and food coloring is mainly used as a colorant.

Preservatives are used to prevent contamination of microorganisms that may occur during the manufacture and use of oral compositions and to help prolong the preservation of toothpaste, and sodium benzoate or parabens may be used.

The toothpaste composition according to the present invention includes a peroxide, a thickener, and a spreading agent, and by including the peroxide and the thickener in a separate form, even if a foaming agent, abrasive, etc. having high compatibility with hydrogen peroxide is used It has an excellent whitening effect due to faster decomposition of hydrogen peroxide in anhydrous state, and is characterized by excellent feeling and stability.

1 is a comparison result of the appearance when the toothpaste tube is cut in half after being stored in a tube state in a 50 ℃ thermostat for 4 weeks.

Hereinafter, the present invention will be described in more detail by way of Examples. However, the following examples are only for illustrating the present invention, and the scope of the present invention is not limited thereto.

Preparation of Examples and Comparative Examples

(1) Preparation of Examples 1 to 6

The toothpaste compositions of Examples 1 to 8 were prepared with the components and composition ratios shown in Table 1 below.

Specifically, put all the liquid ingredients in the wetting agent (PG, PEG, glycerin) and mix well, then disperse the abrasive (CPP, silica) and thickener (PVP or crossed linked PVP) well. Other ingredients (additives, etc.) are dispersed there, stirred for about 20 minutes, a surfactant (SLS, etc.) is added thereto, stirred for about 20 minutes in a vacuum, hydrogen peroxide and fragrance are added, and about 20 minutes in a vacuum The toothpaste was prepared by stirring for a minute. The manufacturing method of the present invention is not limited thereto.

Example
One Example
2 Example
3 Example
4 Example
5 Example
6 Example
7 Example
8 PG 32.3 33.3 32.8 41.88 42.88 42.38 34.8 34.8 PEG 10 10 10 10.2 10.2 10.2 10 10 Glycerin 10 10 10 2.5 2.5 2.5 10 10 EO-PO block co-polymer 10 10 10 11.4 11.4 11.4 10 10 NaF 0 0 0 0.21 0.21 0.21 0 0 SMFP 0.68 0.68 0.68 0.68 0.68 TSPP 1.5 1.5 1.5 1.0 1.0 1.0 1.5 1.5 SAPP 0.5 0.5 0.5 1.0 1.0 1.0 0.5 0.5 silica 2 2 2 3.0 3.0 3.0 2 2 CPP 15 15 15 10 10 10 15 15 sorbitan monooleate 2 0 0.5 2 0 0.5 2 2 sorbitan monostearate 0 One 0 0 One 0 0 0 Polysorbate80 0 0 1.0 0 0 1.0 0 0 PVP 0 0 0 5.5 Crosslinked PVP 10.5 10.5 10.5 11.0 11.0 11.0 5.5 0 PVP-H ₂ O ₂ complex (H ₂ O ₂ 19%) 0 0 0 0 0 0 0 5.5 Crosslinked PVP-H ₂ O ₂ complex (H ₂ O ₂ 19%) 0 0 0 0 0 0 5.5 0 H ₂ O ₂ (35%) 3.0 3.0 3.0 3.0 3.0 3.0 0 0 SLS 2.0 2.0 2.0 2 2 2 2 2.0 sodium saccharin 0.5 0.5 0.5 0.8 0.8 0.8 0.5 0.5 sucralose 0.02 0.02 0.02 0.01 0.01 0.01 0.02 0.02 water 0 0 0 0 0 0 0 0

(2) Preparation of Comparative Examples 1 to 6

In the same manner as in the preparation of Example 1, except for whether hydrogen peroxide is included, whether or not calcium pyrophosphate (CPP) is included, a component of a thickener (Crosslinked PVP-H ₂ O ₂ complex) and a spreading agent are not included. To 5 toothpaste compositions were prepared with the components and composition ratios shown in Table 2 below, and a commercially available median dental white whitening toothpaste (containing hydrogen peroxide, no abrasives, and water) was prepared in Comparative Example 6.

Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 PG 34.3 36.81 34.31 51.81 37.3 PEG 10 10 10 10 10 Glycerin 10 10 10 10 10 EO-PO block co-polymer 10 10 10 10 10 NaF 0 0 0 0 0 SMFP 0.68 0.68 0.68 0.68 0.68 TSPP 1.5 1.5 1.5 1.5 1.5 SAPP 0.5 0.5 0.5 0.5 0.5 silica 2 2 2 2 2 CPP 15 15 15 0 15 sorbitan monooleate 0 0 0 0 0 sorbitan monostearate 0 0 0 0 0 Polysorbate80 0 0 0 0 0 PVP 0 0 10.5 0 0 Crosslinked PVP 10.5 5.5 0 5.5 10.5 PVP-H ₂ O ₂ complex 0 0 0 0 0 Crosslinked PVP-H ₂ O ₂ complex 0 5.5 0 5.5 0 H ₂ O ₂ (35%) 3.0 0 3.0 0 0 SLS 2.0 2 2 2 2.0 sodium saccharin 0.5 0.5 0.5 0.5 0.5 sucralose 0.02 0.01 0.01 0.01 0.02 water 0 0 0 0 0

Experimental Example 1. Measurement of stability of toothpaste

(1) Method for measuring the stability of hydrogen peroxide over high temperature

This is a titration method using iodine, which is an indirect measurement method of hydrogen peroxide concentration. The hydrogen peroxide concentration of the toothpaste at the initial stage of manufacture and the hydrogen peroxide concentration of the toothpaste are measured after storage in a tube in a 50 ℃ constant temperature water bath for 4 weeks. was calculated. When no decomposition occurred at all, it was expressed as 100%.

(2) Method for measuring phase stability at high temperature of toothpaste

When the toothpaste is squeezed after 4 weeks of storage in a 50 ℃ constant temperature water bath, the surface condition to check whether there is any liquid separation was visually observed.

(3) Stability measurement result of toothpaste

Table 3 below shows the results of measuring the high temperature stability of the hydrogen peroxide and the phase stability of the toothpaste at high temperature for each of the toothpaste compositions of Examples 1 to 3, 7 and 8 and Comparative Examples 1 to 5.

50 ℃ storage Example 1 Example 2 Example 3 Example 7 Example 8 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Residual peroxide ratio (%) after 4 weeks 90% 91% 90% 91% 90% 86% 88% 88% 86% additive-free In-tube toothpaste phase stability after 4 weeks 5 5 5 4 4 3 One 2 2 3

Through the results of Table 3, it was confirmed that the peroxides of the toothpaste compositions of Examples 1 to 3, 7 and 8 did not decompose more than 90% even after 4 weeks, and the toothpaste compositions of Comparative Examples 1 to 5 were separated after 4 weeks. It was confirmed that the toothpaste compositions of Examples 1 to 3 and 7 after 4 weeks were not separated in the tube and adhered well (FIG. 1). This is, by using a spreading agent, the toothpaste composition is in close contact with the tube and water generated by perhydrolysis does not exist between the toothpaste composition to suppress the phase separation phenomenon, even in the case of a toothpaste composition comprising hydrogen peroxide and a thickener in a separated form, It suggests that the stability of the toothpaste is remarkably improved.

Experimental Example 2. Measurement of feeling and whitening effect of toothpaste

(1) How to measure freshness and feeling of cleansing

Ten adults were asked to brush their teeth with the toothpaste compositions of Examples 1 to 8 and Comparative Examples 1 to 6 three times a day for at least 1 minute at a time, and after allowing them to be used for a month, questionnaire evaluation was conducted for freshness and cleansing sensation.

Survey Response Criteria

5: Refreshing and refreshing as if using conventional paste toothpaste.

4: Both the feeling of cleanliness and freshness after use are acceptable.

3: After use, one of the two feelings of cleanliness and freshness is acceptable.

2: I don't want to use a separate paste toothpaste after use, but both the cleanliness and freshness are insufficient.

1: After use, it is so steamy that I want to use a separate paste toothpaste.

(2) How to measure stickiness

Ten adults were asked to brush their teeth with the toothpaste compositions of Examples 1 to 8 and Comparative Examples 1 to 6 three times a day for at least 1 minute at a time, and after allowing them to be used for a month, questionnaire evaluation was conducted on stickiness.

Survey Response Criteria

5: Not sticky at all

4: It is a little sticky, but there is no problem to use it.

3: It is very sticky, but there is no problem in using it.

2: Too sticky to brush your teeth

1: It is too sticky, so it is inconvenient to squeeze it on the toothbrush.

(3) Method of measuring whitening effect and cleaning power

For 10 adults, the toothpaste compositions of Examples 1 to 8 and Comparative Examples 1 to 6 were used to brush their teeth 3 times a day for at least 1 minute at a time, and after allowing them to be used for a month, a questionnaire was evaluated for the whitening effect and cleaning power.

Survey Response Criteria

5: The teeth are clearly brightened.

4: The surface becomes smooth and the teeth appear brighter.

3: The teeth seem to have brightened slightly.

2: The surface seems to have become slightly cleaner.

1: I do not know the difference between the whitening effect and the feeling of cleansing before and after use.

(4) in vitro How to measure teeth whitening effect

After making artificial teeth (hydroxyapatite, which is a material that makes up most of tooth enamel and dentin) into tablet specimens, and using tea, coffee, mucin, metal salt, etc. When brushing 5,400 times at a rate of 90 times per second with a slurry of the actual concentration of toothpaste (25g/40mL) using a chroma meter, the degree of brightening of the colored artificial tooth specimen before and after cleaning was measured with a chroma meter and the amount of color change (Δ E ) was calculated.

(5) Measurement result of feeling of use and whitening effect

1) Measurement result of usability

Table 4 shows the results of measuring the in vitro tooth whitening effect of the toothpaste compositions of Examples 1 to 8 and Comparative Examples 1 to 6, respectively.

line
city
Yes
One line
city
Yes
2 line
city
Yes
3 line
city
Yes
4 line
city
Yes
5 line
city
Yes
6 line
city
Yes
7 line
city
Yes
8 rain
school
Yes
One rain
school
Yes
2 rain
school
Yes
3 rain
school
Yes
4 rain
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Yes
5 rain
school
Yes
6 Refreshing and cleansing feeling 5 5 5 5 5 5 5 2 4 4 2 2 One One stickiness 5 5 5 5 5 5 5 One 5 5 One 4 5 5 Whitening effect and cleaning power 5 5 5 5 5 5 4 4 4 4 4 3 2 3

Through the results in Table 4, the toothpaste compositions of Examples 1 to 8 were refreshing and refreshing compared to Comparative Examples 1 to 6, and had an excellent cleaning feeling, and was not sticky at all, and the teeth were remarkably brightened, resulting in excellent whitening effect. was confirmed. This suggests that by using crosslinked PVP as a thickener, there is no stickiness at all and the feeling of use is improved.

2) in vitro Teeth whitening effect measurement result

Table 5 shows the results of measuring the in vitro tooth whitening effect of the toothpaste compositions of Examples 1 to 3, 7 and 8 and Comparative Examples 2, 4 and 5, respectively.

Example
One Example
2 Example
3 Example
7 Example
8 comparative example
One comparative example
2 comparative example
4 comparative example
5 Δ E
(5400 times) 26.8±
0.44 25.9±
0.71 26.3±
0.90 21.5±
0.57 20.8±
0.29 26.0±
1.02 20.9±
0.25 11.5±
0.85 14.0±
1.20

Through the results in Table 5, compared to the toothpaste compositions of Comparative Examples 2, 4 and 5 containing complex form of hydrogen peroxide and thickener, Examples 1 to 3, 7 and 8 containing hydrogen peroxide and thickener in a separate form It was confirmed that the whitening effect of the toothpaste composition was 1.3 to 2.3 times better. This suggests that, in the case of a toothpaste composition comprising hydrogen peroxide and a thickener in a separate form, a more excellent tooth whitening effect can be exhibited by remarkably rapid decomposition of hydrogen peroxide in actual use.

Claims (17)

A dentifrice composition comprising a peroxide, a thickening agent and a spreading agent, comprising:
The peroxide and the thickener are each in a separate form,
The content of the spreading agent (spreading agent) is 0.1 to 10% by weight based on the total weight of the toothpaste composition, toothpaste composition.
delete According to claim 1, wherein the spreading agent (spreading agent) Span 20 (Span 20, sorbitan monolaurate), Span 40 (Span 40, sorbitan monopalmitate), Span 60 (Span 60, sorbitan monostearate), Span 80 (Span 80) ; sorbitan monooleate), span 85 (Span 85, sorbitan trioleate), and TWEEN (POE sorbitan fatty acid ester) is at least one component selected from the group consisting of, a toothpaste composition.
delete According to claim 1, wherein the thickener is polyvinyl pyrrolidone (poly vinyl pyrrolidone, PVP), crosslinked PVP, polyvinyl alcohol (poly vinyl alcohol, PVA), carboxy methyl cellulose (carboxy methyl cellulose, CMC), polyethylene glycol (polyethylene glycol, PEG), carboxypolymethylene, carboxypropyl cellulose, poloxamer, carrageenan, carboxyvinyl polymers, xanthan gum , polyvinylpyrrolidone-vinyl acetate copolymer (polyvinyl pyrrolidone/vinyl acetate copolymer), at least one component selected from the group consisting of, a toothpaste composition.
The toothpaste composition according to claim 1, wherein the content of the thickener is 5 to 20% by weight based on the total weight of the toothpaste composition.
The method of claim 1, wherein the peroxide is hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium percarbonate, sodium perborate, and sodium pyrophosphate ( tetrasodium pyrophosphate peroxidate) is at least one component selected from the group consisting of,
The content of the peroxide is 0.1 to 10% by weight based on the total weight of the toothpaste composition, toothpaste composition.
delete The toothpaste composition of claim 1, further comprising an abrasive.
The toothpaste composition according to claim 9, wherein the abrasive is at least one component selected from the group consisting of CPP (calcium pyrophosphate), silica, calcium carbonate, insoluble sodium metaphosphate, zirconium silicate and hydroxyapatite.
The toothpaste composition according to claim 9, wherein the content of the abrasive is 5 to 20% by weight based on the total weight of the toothpaste composition.
The toothpaste composition according to claim 1, wherein the toothpaste composition does not contain water or contains 0.01 to 10% by weight of water based on the total weight of the toothpaste composition.
delete According to claim 1, wherein the viscosity of the toothpaste composition is 60,000 to 150,000 cP or less, the toothpaste composition.
The toothpaste composition according to claim 1, wherein the toothpaste composition is for teeth whitening.
The toothpaste composition according to claim 1, wherein the toothpaste composition has improved phase stability even at 30 to 60°C.
The toothpaste composition according to claim 1, wherein the toothpaste composition further comprises one or more components selected from the group consisting of surfactants, wetting agents, medicinal agents, additives and foaming agents.

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