KR102090119B1 - Toothpaste composition comprising herbal extract mixture as effective component - Google Patents

Abstract

The present invention relates to a toothpaste composition comprising a herbal extract mixture consisting of astragalus, zichi, corn cob, epidermis, kwakyang, mint, lichen and licorice, and the toothpaste composition of the present invention improves periodontitis, gum bleeding and tooth swelling symptoms It can be used in toothpaste compositions for the prevention or treatment of oral hygiene and gum disease, because it has an excellent deodorizing effect and can manage the oral cavity hygienically just by brushing teeth and, furthermore, the consumer satisfaction is quite good.

Description

Toothpaste composition comprising herbal extract mixture as effective component

The present invention relates to a toothpaste composition containing the herbal extract mixture as an active ingredient.

More than 400 types of bacteria are reproduced in the human mouth, and the number of bacteria reaches 10 billion. In addition, the number of bacteria in the saliva of 10 ⁸ to 10 ⁹ CFU / mL is detected. The teeth are perforated with a large number of microscopic holes, so that bacteria causing tooth decay enter the aforementioned holes and make the teeth sick, which is tooth decay. These cavities are also known as dental caries as one of the most common diseases seen in teeth. It is an infectious bacterial disease in which food in the oral cavity is decayed by acid-resistant streptococcus and lactic acid bacteria and the components of teeth are destroyed by acid. In Korea, the morbidity rate of permanent teeth reaches about 80%, and one person has been reported to have on average 2 to 3 cavities.

Several causes of tooth decay have been found to work in combination, but the most important is dental plaque. There are many bacteria in plaque, especially acid-resistant streptococcus and lactic acid bacteria, among which Streptococcus mutans is known as the main cavities. Streptococcus mutans attaches to the surface of the tooth and grows, using sugar in food to produce acid to corrode the tooth and at the same time invade the tooth bone cells, causing various alveolar bone corrosion and gum disease. More specifically, the occurrence of tooth decay is the first step in the process of forming plaque on the tooth surface by the causative agent, and the second step is the process in which organic acid is generated in the plaque. It consists of a third step of demineralizing the inorganic substances constituting the surface of the tooth by an enzyme or the like and further dissolving the organic substance. In addition, in the case of periodontal disease, plaque attached to the periodontal and periodontal tissues is the main cause of the development and progression of periodontal disease. As a result, bacteria in the plaque produce harmful metabolites or bacterial enzymes, resulting in gingivitis. And is said to advance.

Bad breath refers to the smell that originates from the oral cavity and adjacent organs, and many people complain of discomfort in their daily life through bad breath. 85-90% of bad breath comes from the oral cavity, especially from the back of the tongue. The main components of bad breath are volatile sulfur compounds, with 90% of the total amount of volatile sulfur compounds being hydrogen sulfide made from cysteine and methyl mercaptan and dimethyl sulfide made from methionine. These components are produced primarily by protein enzymes released by anaerobic bacteria, and the back of the tongue is the most important habitat. This area is not well cleaned by saliva and has many small depressions, making it a place for bacteria to continue to live. The production of volatile sulfur compounds by anaerobic bacteria is the most important cause of bad breath, but it is also caused by oral diseases such as tooth decay and periodontitis. Although many types of anaerobic bacteria are involved in the development of bad breath, in particular, typical bacteria of bad breath generation are Porphyromonas gingivalis and Prevotella intermedia , which secrete many types and large amounts of enzymes. ), Fusobacterium nucleatum ), Bacteroides forsythus , Treponema deticola ), and is also known as a representative causative agent causing periodontitis. In order to suppress bad breath, it is most effective to suppress the growth of anaerobic bacteria that produce volatile sulfur compounds, which are the main component of bad breath, so conventionally, tongue tongue scraper is used to remove the bacterial growth substrate from the tongue. Metal salts such as zinc chloride or disinfectants such as alcohol or chlorhexidine were used to remove or inhibit the growth of anaerobic bacteria or the formation of volatile sulfur compounds by anaerobic bacteria. However, these metal salts or disinfectants inhibit the occurrence of not only anaerobic bacteria that cause bad breath, but also other microorganisms in the oral cavity, and since these substances are not swallowed by the esophagus, they do not go to the back of the tongue, an important place for bad breath, and gargle mainly in the front of the mouth. It is spit out of the mouth. Therefore, there is a problem in that it cannot be disinfected up to the back of the tongue, which is the main growth site of bad breath-producing anaerobic bacteria. In addition, these substances are diluted with saliva and swallowed with the saliva into the esophagus, so that the effect in the oral cavity is only about 20 minutes to 2 hours, after which microorganisms multiply in the oral cavity and bad breath occurs.

Toothpaste is a quasi-drug used when brushing the surface of teeth, and is mainly used for whitening, sterilization, and interdental cleansing purposes. To this end, toothpaste generally contains ingredients such as abrasives, wetting agents, foaming agents, and sweeteners. Including. Recently, many studies have been conducted to manufacture various functional toothpastes to improve tooth decay, periodontitis, and bad breath suppression effects. In addition, periodontal disease has recently attracted attention as a risk factor for myocardial infarction, arteriosclerosis, diabetes, and premature birth, as well as chronic infection of gum tissue. Therefore, it suggests the possibility of using toothpaste as a basis for improving various health conditions. On the other hand, in general, 0.05 to 0.1% (w / v) of fluorine is often used in toothpaste or mouthwash to prevent tooth decay or periodontitis. According to a recent report, the use of fluorine compounds in toothpaste or mouthwash etc. indicates dental caries. Although silver can be prevented, long-term and repeated use of fluorine compounds has been found to promote inflammation in the gums. Therefore, there is a need for a toothpaste composition capable of suppressing this phenomenon and preventing dental caries without using fluorine.

On the other hand, Korean Patent Publication No. 2016-0084904 discloses a composition for promoting oral hygiene containing a natural herbal extract as an active ingredient, and Korean Patent Publication No. 2017-0141027 for preventing or treating oral diseases containing astragalus extract The composition is disclosed. However, the toothpaste composition containing the herbal extract mixture of the present invention as an active ingredient has not been disclosed so far.

The present invention has been derived by the above-mentioned needs, the present inventors, when using a toothpaste composition comprising a herbal extract mixture consisting of astragalus, qichi, corn stalk, zephyr, kwakyang, mint, taps and licorice, In addition to high preference, periodontitis, gum bleeding and tooth tingling symptoms were improved, and the present invention was completed by confirming that the effect of removing bad breath was excellent.

In order to solve the above problems, the present invention provides a toothpaste composition containing the herbal extract mixture as an active ingredient.

Toothpaste composition comprising a herbal extract mixture consisting of astragalus, qi, corncob, epidermis, kwakyang, peppermint, lichen and licorice of the present invention has improved periodontitis, gum bleeding and tooth tingling symptoms, has excellent bad breath removal effect and gargles It is possible to hygienically manage the oral cavity by itself, and furthermore, since customer satisfaction is quite excellent, it can be usefully used in a toothpaste composition for prevention or treatment of oral hygiene and gum disease.

In order to achieve the object of the present invention, the present invention provides a toothpaste composition containing the herbal extract mixture as an active ingredient.

The term "herbal medicine" used in the present invention includes, but is not limited to, astragalus, qichi, corn stalk, zephyr, kwakyang, peppermint, nipple and licorice.

In the toothpaste composition of the present invention, the extraction mixture may be prepared by mixing after each extraction using water, a lower alcohol having 1 to 4 carbon atoms, or a mixture thereof, preferably 1) astragalus, fern, corncob, Washing the cuticles, kwakyang, peppermint, taps and licorice, cutting them with a grinder and drying them; 2) extracting hot water by adding water to each material dried in step 1); And 3) mixing each extract obtained in step 2) above, but is not limited thereto.

In the step of preparing a herbal extract mixture by mixing each of the extracts obtained in step 3), the herbal extract mixture of the present invention is 30-50% by weight of astragalus extract, 5-15% by weight of extract of Chichi, 5-15% by weight % Corn stalk extract, 5-15 wt% epidermal extract, 5-15 wt% gwakyang extract, 5-15 wt% mint extract, 2.5-7.5 wt% nipple extract and 2.5-7.5 wt% licorice It may be prepared by mixing the extract, preferably 40% by weight of astragalus extract, 10% by weight of Chichi extract, 10% by weight of corn cob extract, 10% by weight of skin extract, 10% by weight of Kwakyang extract, 10 It may be prepared by mixing a weight% peppermint extract, 5% by weight of a branch extract and 5% by weight of licorice extract, but is not limited thereto.

In addition, each of the herbal extracts may further perform a conventional fractionation process, or may be purified using a conventional purification method. There is no limitation in the method for preparing the herbal extract used in the present invention, and any known method can be used.

For example, each of the herbal extracts of astragalus, zichi, corn cob, epidermis, kwakyang, peppermint, stalk and licorice contained in the composition of the present invention is silica gel column chromatography, thin layer chromatography Further purified fractions may be obtained using various chromatography methods such as chromatography and high performance liquid chromatography.

Therefore, each of the herbal extracts of the present invention is a concept that includes all of the extracts, fractions and refinements, their dilutions, concentrates or dried products obtained at each stage of extraction, fractionation or purification.

In addition, in the toothpaste composition of the present invention, the herbal extract mixture may be included in an amount of 26 to 31% by weight based on the total weight of the composition, preferably 28.5% by weight, but is not limited thereto.

In addition, the toothpaste composition of the present invention, in addition to the above-mentioned active ingredients (Astragalus, Chichi, corn stalk, peel, kwakyang, peppermint, branch, and licorice), abrasives, caking agents, wetting agents, foaming agents, sweeteners, flavoring agents, preservatives, antibacterial Additives such as substances may be further contained.

The abrasive is a substance that functions to remove plaque in the oral cavity, silica-based abrasives such as silicic acid, crystalline silica, amorphous silica, silica gel, aluminosilicate, zeolite, calcium hydrogen phosphate anhydride, calcium hydrogen phosphate dihydrate , Calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, zirconium silicate, or the like may be used, but is not limited thereto.

The caking agent is a material for preventing the separation of the powdery component and the liquid component, gelatin, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carrageenan, sodium alginate, xanthan gum, sodium polyacrylate, gum arabic, guar gum , Polyvinyl alcohol, polyvinylpyrrolidone, or the like may be used in one or more types, but is not limited thereto.

The wetting agent is a substance that prevents the toothpaste from contacting and hardening in the air in order to suppress evaporation of moisture and water in the toothpaste. One or two types of glycerin, sorbitol, propylene glycol, butylene glycol, glycerin, propanediol, etc. It can be used above, but is not limited thereto.

The foaming agent complements the cleaning action of the abrasive and penetrates into the hard-to-reach areas where the toothbrush is difficult to reach, as well as serves to increase the sense of brushing by generating air bubbles, helps the cleaning action and quickly disperses and penetrates the drug. And reducing the interfacial tension, so that foreign substances in the oral cavity can easily fall off. Anionic surfactants such as sodium lauryl sulfate and sodium alkyl sulfate are used, and nonionic surfactants such as polyoxyethylene, polyoxypropylene, copolymer, and polyoxyethylene cured castor Free, polyoxyethylene sorbitan fatty acids, alkanol amide fatty acid esters, sucrose fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene fatty acid esters and polyoxyethylene castor cured oil derivatives are used, and natural surfactants extracted from plants Can be used However, it is not limited thereto.

The sweetener is a substance for providing a certain sense of aesthetics to toothpaste and imparting a refreshing feeling, and the like, xylitol, stevia, steviol glycoside, saccharin, or the like may be used, but is not limited thereto.

The flavoring agent cleanses the oral cavity, gives freshness, and suppresses an unpleasant odor in the oral cavity. Peppermint oil, spermint oil, orange oil, lime oil, lemon oil, L-menthol, various fruit flavors, coolmint Fragrance (HF-61399), combination fragrance (apple fragrance, HF-30630) may be used in one or two or more, but is not limited thereto.

In addition, propolis, which is an antibacterial substance that can be contained in the toothpaste composition of the present invention, is a natural antibacterial substance as a mixture of resinous substances collected by bees from plants such as tree buds and sap. It has antibacterial, bactericidal and immune system activation, immune function enhancing action, cell activation and cell regeneration action, anti-allergic action, gene damage defense action, blood vessel strengthening action, antioxidant action, and anti-cancer drug side effects.

Therefore, the toothpaste composition of the present invention is 30 to 50% by weight of astragalus extract, 5 to 15% by weight of Chichi extract, 5 to 15% by weight of corncob extract, 5 to 15% by weight of scalp extract, 5 to 15% by weight 26-31% by weight of the herbal extract mixture, including Kwak-hyang extract, 5-15% by weight peppermint extract, 2.5-7.5% by weight branch extract and 2.5-7.5% by weight licorice extract; Fruit tree extract 3.5-4.5 wt%; Dental abrasive silica 9-11 wt%; Dental Viscosity 5-7% by weight of silica; Glycerin 28-32 wt%; Propane diol (sugar moisturizer) 9-11 wt%; Xanthan gum 0.7-0.9 wt%; Sodium cocoyl apple amino acids 2-4% by weight; Xylitol 4-6% by weight; Stevia 0.1-0.3 wt%; Propolis 0.5-1.5 wt%; 0.5 ~ 1.5% by weight of a natural preservative (napri) derived from the bark fruit extract, grandiflora flower extract or asusne extract; And lemon essential oil 0.4 to 0.6% by weight; may contain, preferably 40% by weight of astragalus extract, 10% by weight of Chichi extract, 10% by weight of corncob extract, 10% by weight of skin extract, 10% by weight 28.5% by weight of the herbal extract mixture comprising:% Kwak-hyang extract, 10% by weight peppermint extract, 5% by weight branch extract and 5% by weight licorice extract; 4% by weight of extracts from fruitless tree; Dental abrasive silica 10% by weight; Dental viscosity 6% by weight of silica; Glycerin 30% by weight; Propanediol 10% by weight; Xanthan gum 0.8 wt%; Sodium cocoyl apple amino acids 3% by weight; Xylitol 5 wt%; Stevia 0.2% by weight; Propolis 1% by weight; 1% by weight of a natural preservative derived from the bark fruit extract, grandiflora flower extract, or EARSNER extract; And lemon essential oil 0.5% by weight; may contain, but is not limited to.

In addition, the toothpaste composition of the present invention can be prepared in any one formulation selected from cream, powder, paste, and transparent gel types, but can be prepared in any type of formulation as long as it can function as a toothpaste composition.

Hereinafter, the present invention will be described in more detail using examples. It is obvious to those skilled in the art that these examples are only intended to illustrate the present invention in more detail and that the scope of the present invention is not limited by them.

Example  1. Preparation of herbal extract mixture

After extracting the primary hot water by adding water to each of astragalus, zichi, corn stalk, zephyr, kwakyang, mint, branch, and licorice, the primary extract is decomposed and extracted with ethyl acetate and water to prepare a distribution extract from the ethyl acetate organic layer Then, the distribution extract was concentrated under reduced pressure to obtain a second extract, separated by chromatography, and then purified to obtain a final extract. The obtained extracts of astragalus, qi, corn cob, zephyr, kwak yang, mint, branch licorice and licorice alone were mixed at the mixing ratios shown in Table 1 below to prepare a herbal extract mixture of the present invention.

Composition and blending ratio of the herbal extract mixture of the present invention Ingredient weight(%) Astragalus mongholicus ) 40 Lithospermum erythrorhizon ) 10 Corn stand ( Zea mays ) 10 Zephyr ( Zanthoxylum piperitum ) 10 Teucrium veronicoides ) 10 Peppermint ( Mentha arvensis ) 10 Solanum melongena ) 5 Licorice ( Glycyrrhiza uralensis ) 5 Gross weight 100

Comparative example  1. Preparation of Chichi Sole Extract

After extracting the primary hot water by adding water to the Chichi, the primary extract was decomposed and extracted with ethyl acetate and water to prepare a distribution extract from the ethyl acetate organic layer, and then concentrated under reduced pressure to obtain a secondary extract, followed by chromatography After separating into and purifying, a single extract of Chichi was finally obtained.

Comparative example  2. Preparation of astragalus sole extract

After extracting the first hot water by adding water to the astragalus, the primary extract is decomposed and extracted with ethyl acetate and water to prepare a distribution extract from the ethyl acetate organic layer, and then concentrated under reduced pressure to obtain a secondary extract, followed by chromatography After separating with and purifying, finally, an extract of astragalus was obtained.

Comparative example  3. Preparation of extract mixture of Chichi and Astragalus

The extract of Chichi and astragalus extract obtained from Comparative Examples 1 and 2 were mixed in a weight ratio of 1: 1 to obtain an extract mixture of Chichi and astragalus.

Experimental Example  1. Sensory evaluation according to preparation and use of toothpaste composition comprising the herbal extract mixture of the present invention

The present inventors include herbal extracts made of astragalus, qichi, corn stalk, zephyr, kwakyang, mint, branched licorice and licorice as an active ingredient prepared as in Example 1 above as herbal medicine plants. extract); Abrasives (dental type silica); Wetting agents (glycerin and propanediol); Caking agents (xanthan gum); Natural surfactant (apple wash) extracted from apple juice; Sweeteners (xylitol and stevia); Natural antibacterial substances (propolis); A natural preservative (napri) extracted from a bark fruit extract, a grandiflora extract or an awnier extract; And a flavoring agent (lemon essential oil) was prepared, and the effect of improving the symptoms of gum disease and removing bad breath was confirmed. The toothpaste compositions of Comparative Examples 1 to 3, each containing extracts of astragalus extracts, astragalus extracts and extracts of astragalus and astragalus as active ingredients, were prepared and used as a comparative control (Table 2).

To use the toothpaste composition prepared in Example 1 of the present invention for 50 adults (30 males and 20 females) over the age of 40 who do not have periodontal disease, and investigate the following items to obtain results for the average value Table. The evaluation was a 5-point scale, and was evaluated as 5-very good, 4-good, 3-moderate, 2-bad, and 1-very bad. As a result, in the case of the toothpaste composition prepared in Example 1 comprising a herbal extract mixture consisting of astragalus, arachnids, corncobs, skins, kwakyang, peppermint, sprigs and licorice of the present invention as disclosed in Table 3 below, Compared to each toothpaste composition prepared in Comparative Examples 1 to 3, which includes a control group extract of Chichi alone, an extract of Hwanggi alone and an extract mixture of Chichi and Hwanggi, the overall satisfaction was very high, and the difference in total score was also doubled. I could confirm that it was close.

In addition, 100 subjects with gum disease and bad breath, such as periodontitis, bleeding from the gums, and teething symptoms, were screened and then randomly divided into 10 groups of 10 subjects. Ten subjects divided into 10 groups were allowed to use each toothpaste prepared in Example 1 and Comparative Examples 1 to 3 three times a day for 4 weeks. Measurement of the effect of improving gum disease was performed by subjecting each test group to each toothpaste prepared in Example 1 and Comparative Examples 1 to 3 for 4 weeks, and then satisfaction with improvement in gum disease such as periodontitis, bleeding of the gums, and this tingling After evaluating on a 5-point scale, the average value was measured. The evaluation was a 5-point scale, and 1 point: very dissatisfied, 2 points: dissatisfied, 3 points: moderate, 4 points: satisfied, 5 points: very satisfied.

On the other hand, the effect of removing bad breath was applied to each test group before and after using each toothpaste prepared in Example 1 and Comparative Examples 1 to 3 (before the experiment and before brushing) and after 4 weeks (after the experiment and immediately after brushing) ) Was measured using a halitometer (Halimeter) and the average value was compared.

As a result, in the case of the toothpaste composition prepared in Example 1 comprising a herbal extract mixture consisting of astragalus, qichi, corn stalk, skin, kwakyang, peppermint, branch, and licorice of the present invention as disclosed in Table 4 below, Compared to each toothpaste composition prepared in Comparative Examples 1 to 3, which includes a control group extract of qichi, astragalus extract and extract mixture of qichi and astragalus, improving effect and bad breath of gum disease symptoms such as periodontitis, gingival hemorrhage It was confirmed that the removal effect was remarkably excellent.

Composition and blending ratio of toothpaste composition Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Herbal extract mixture 28.5 - - - Chichi extract - 28.5 - - Astragalus extract - - 28.5 - Extract mixture of Chichi and Astragalus - - - 28.5 Fruit tree extract 4 4 4 4 Dental polishing silica 10 10 10 10 Dental Viscosity Silica 6 6 6 6 glycerin 30 30 30 30 Sugar moisturizer (propanediol) 10 10 10 10 Xanthan gum 0.8 0.8 0.8 0.8 Apple Wash 3 3 3 3 Xylitol 5 5 5 5 Stevia 0.2 0.2 0.2 0.2 Propolis One One One One Nafri One One One One Lemon essential oil 0.5 0.5 0.5 0.5 Total amount (%) 100 100 100 100

Evaluation of the usability according to the composition ratio of the components of toothpaste Constellation Viscosity flavor Flavor Air bubbles Cleaning power Refreshment Total score Example 1 5 4 4 4 5 4 3 29 Comparative Example 1 2 2 One 2 2 3 3 15 Comparative Example 2 One 2 2 One 4 2 2 14 Comparative Example 3 2 2 2 2 4 One 2 15

Improvement of symptoms of gum disease and removal of bad breath according to active ingredients of toothpaste composition division Item Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Gum disease Periodontitis 4.5 2.8 2.5 2.9 Bleeding gums 4.7 3.2 2.8 3.0 Iga Sirim 3.8 2.8 2.8 2.2 Bad breath Just before the experiment 207.5 200.0 205.1 204.5 4 weeks later 110.1 132.2 135.2 138.5

Claims (5)

30 ~ 50% by weight of astragalus extract, 5 ~ 15% by weight of Chichi extract, 5 ~ 15% by weight corncob extract, 5 ~ 15% by weight skin extract, 5 ~ 15% by weight Kwakyang extract, 5 ~ 15% by weight 26% to 31% by weight of an herbal extract mixture comprising% peppermint extract, 2.5% to 7.5% by weight of the extract, and 2.5% to 7.5% by weight of licorice extract; Fruit tree extract 3.5-4.5 wt%; Dental abrasive silica 9-11 wt%; Dental Viscosity 5-7% by weight of silica; Glycerin 28-32 wt%; Propanediol 9-11 wt%; Xanthan gum 0.7-0.9 wt%; Sodium cocoyl apple amino acids 2-4% by weight; Xylitol 4-6% by weight; Stevia 0.1-0.3 wt%; Propolis 0.5-1.5 wt%; 0.5 ~ 1.5% by weight of a natural preservative derived from the extract of bark berry fruit, granny flower extract, or essence extract; And Lemon essential oil 0.4 ~ 0.6% by weight; Toothpaste composition containing. delete The method of claim 1, wherein the herbal extract mixture is a toothpaste composition, characterized in that prepared by mixing after each extraction using water, a lower alcohol having 1 to 4 carbon atoms or a mixture thereof. delete According to claim 1, wherein the composition is a toothpaste composition, characterized in that it is prepared in any one formulation selected from cream, powder, paste and transparent gel type.