CN106924162B - Plant additive, bacteriostatic agent, oral care product and application of plant additive in preparation of oral care product - Google Patents
Plant additive, bacteriostatic agent, oral care product and application of plant additive in preparation of oral care product Download PDFInfo
- Publication number
- CN106924162B CN106924162B CN201710188477.0A CN201710188477A CN106924162B CN 106924162 B CN106924162 B CN 106924162B CN 201710188477 A CN201710188477 A CN 201710188477A CN 106924162 B CN106924162 B CN 106924162B
- Authority
- CN
- China
- Prior art keywords
- extract
- oral care
- plant
- oral
- care product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000654 additive Substances 0.000 title abstract description 56
- 230000000996 additive effect Effects 0.000 title abstract description 51
- 239000000022 bacteriostatic agent Substances 0.000 title abstract description 23
- 238000002360 preparation method Methods 0.000 title abstract description 9
- 239000000284 extract Substances 0.000 claims abstract description 47
- 239000002994 raw material Substances 0.000 claims abstract description 21
- 241000241413 Propolis Species 0.000 claims abstract description 19
- 229940069949 propolis Drugs 0.000 claims abstract description 19
- 235000020688 green tea extract Nutrition 0.000 claims abstract description 18
- 229940094952 green tea extract Drugs 0.000 claims abstract description 17
- 244000119298 Emblica officinalis Species 0.000 claims abstract description 15
- 235000015489 Emblica officinalis Nutrition 0.000 claims abstract description 15
- 229940105902 mint extract Drugs 0.000 claims abstract description 14
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 13
- 239000000606 toothpaste Substances 0.000 claims description 18
- 239000002324 mouth wash Substances 0.000 claims description 15
- 229940034610 toothpaste Drugs 0.000 claims description 15
- 229940051866 mouthwash Drugs 0.000 claims description 11
- 239000000668 oral spray Substances 0.000 claims description 9
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 6
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 6
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 6
- 235000011477 liquorice Nutrition 0.000 claims description 6
- 229940041678 oral spray Drugs 0.000 claims description 6
- 241000196324 Embryophyta Species 0.000 abstract description 51
- 239000000419 plant extract Substances 0.000 abstract description 38
- 230000000694 effects Effects 0.000 abstract description 21
- 210000000214 mouth Anatomy 0.000 abstract description 20
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 14
- 206010018276 Gingival bleeding Diseases 0.000 abstract description 13
- 210000002200 mouth mucosa Anatomy 0.000 abstract description 11
- 229940069445 licorice extract Drugs 0.000 abstract description 9
- 241000894006 Bacteria Species 0.000 abstract description 7
- 230000008439 repair process Effects 0.000 abstract description 4
- 239000000047 product Substances 0.000 description 37
- 230000036541 health Effects 0.000 description 10
- 208000025865 Ulcer Diseases 0.000 description 9
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 230000036269 ulceration Effects 0.000 description 9
- 239000001963 growth medium Substances 0.000 description 8
- 230000002147 killing effect Effects 0.000 description 8
- 230000003385 bacteriostatic effect Effects 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- 206010006326 Breath odour Diseases 0.000 description 6
- 230000006872 improvement Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 239000009609 fructus phyllanthi Substances 0.000 description 4
- 230000002195 synergetic effect Effects 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 230000002588 toxic effect Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 244000269722 Thea sinensis Species 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 239000000686 essence Substances 0.000 description 3
- 235000003599 food sweetener Nutrition 0.000 description 3
- 239000003906 humectant Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 239000003765 sweetening agent Substances 0.000 description 3
- 241000191940 Staphylococcus Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 235000009569 green tea Nutrition 0.000 description 2
- 230000008821 health effect Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 241000295644 Staphylococcaceae Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000007760 free radical scavenging Effects 0.000 description 1
- 229940068517 fruit extracts Drugs 0.000 description 1
- 239000013538 functional additive Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 208000011759 gum bleeding Diseases 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 235000020737 peppermint extract Nutrition 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 238000002137 ultrasound extraction Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Abstract
The invention relates to the technical field of oral care products, and provides a plant additive, a bacteriostatic agent, an oral care product and application of the plant additive in preparation of the oral care product. A plant additive comprises at least three plant extracts which are separable from each other, wherein the plant extracts are selected from the group consisting of green tea extract, mint extract, emblic leafflower fruit extract, licorice extract and propolis extract. The additive has comprehensive effect. The bacteriostatic agent is prepared from the plant additive. The bacteriostatic agent has good bactericidal and bactericidal effects. The plant additive can be used for preparing oral care products. The oral care product is prepared from raw materials, wherein the raw materials comprise the plant additive, and the mass percent of the plant additive in the raw materials is 5.2-42%. The oral care product can not only prevent gingival bleeding, repair oral mucosa and eliminate oral peculiar smell, but also kill various bacteria in oral cavity.
Description
Technical Field
The invention relates to the technical field of oral care products, in particular to a plant additive, a bacteriostatic agent, an oral care product and application of the plant additive in preparation of the oral care product.
Background
With the improvement of living standard of people, more and more people pay attention to oral health, and people know that the oral health is very important, and the oral health care products which are commonly used at present mainly comprise the following types: toothpaste: the toothpaste is a common cleaning product in daily life, along with the continuous development of scientific technology, the continuous improvement and perfection of technological equipment, various types of toothpaste comes out in succession, the quality and the grade of products are continuously improved, and the existing toothpaste variety is developed into multifunctional toothpaste with complete variety, multiple functions and hundreds of brands from single cleaning type toothpaste, so that the requirements of consumption levels of different levels are met. Mouthwash: more and more people use the mouthwash to improve the oral health, and the mouthwash can clean the oral cavity and prevent decayed teeth, periodontitis and the like. Oral cavity spraying: has effects of clearing away heat and toxic materials, relieving inflammation, and relieving pain.
However, at present, these oral care products have single efficacy, especially aiming at comprehensively preventing and treating gingival bleeding, repairing oral mucosa, eliminating oral odor, killing oral bacteria and the like. Therefore, the development of a fully functional oral care product is an urgent problem to be solved at present.
Disclosure of Invention
The first purpose of the invention is to provide a plant additive, which has comprehensive efficacy.
The second purpose of the invention is to provide a bacteriostatic agent which has good bactericidal and bactericidal effects.
A third object of the present invention is to provide a use of a plant additive in the preparation of an oral care product.
It is a fourth object of the present invention to provide an oral care product which can prevent bleeding of gums, repair oral mucosa, eliminate bad breath, and kill various bacteria in the oral cavity.
The technical problem to be solved by the invention is realized by adopting the following technical scheme:
A plant additive comprises at least three plant extracts which are separable from each other, wherein the plant extracts are selected from the group consisting of green tea extract, peppermint extract, emblic leafflower fruit extract, licorice extract and propolis extract.
A bacteriostatic agent is prepared from the above plant additive.
An application of the plant additive in preparing oral care product is provided.
An oral care product is prepared from raw materials, wherein the raw materials comprise the plant additive, and the mass percent of the plant additive in the raw materials is 5.2-42%.
The plant additive, the bacteriostatic agent, the oral care product and the application of the plant additive in preparing the oral care product have the beneficial effects that:
The plant additive provided by the invention comprises at least three plant extracts which can be separated from each other, wherein the plant extracts have pure natural functions and are harmless to human bodies; the setting of at least three is beneficial to promoting the function of the prepared plant additive to be more comprehensive; the mutually separable setting is beneficial to the prepared plant additive can be added into other products in a wider form, and the application range of the plant additive is expanded; the plant extracts are selected from green tea extracts, mint extracts, emblic leafflower fruit extracts, liquorice extracts and propolis extracts, the plant extracts have natural antibacterial and bactericidal capabilities, and the plant extracts can cooperate with one another to achieve the effects of protection and health care more comprehensively.
The plant additive has good bacteriostatic and bactericidal functions, so that the bacteriostatic agent with good bacteriostatic and bactericidal functions can be prepared on the basis of the plant additive.
The plant additive provided by the invention is pure natural, harmless to human body and has multiple-effect and comprehensive functions, so that the plant additive can be applied to preparing oral care products.
The oral care product provided by the invention is prepared from raw materials, wherein the raw materials comprise the plant additive, and the mass percentage of the plant additive in the raw materials is 5.2-42%. The content of the plant additive in the oral care product is obtained through creative tests, and within the mass percentage range, the prepared oral care product has the best effects of preventing gingival bleeding, repairing oral mucosa, eliminating oral peculiar smell and inhibiting bacteria and killing bacteria.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
the plant additives, bacteriostatic agents, oral care products and the application of the plant additives in the preparation of the oral care products of the embodiments of the present invention are specifically described below.
the plant additive provided by the embodiment of the invention comprises plant extracts. The plant extract is a product formed by taking plants as raw materials, directionally obtaining and concentrating one or more active ingredients in the plants through a physical and chemical extraction and separation process according to the requirements of the application of an extracted final product without changing the structures of the active ingredients, is natural and harmless to human bodies, and is very suitable to be used as an additive for auxiliary health care.
It should be noted that the kinds of the plant extracts are not particularly limited, and in this embodiment, it is preferable that at least three kinds of the plant extracts are used in order to make the functions of the prepared plant additive more comprehensive.
The combination between the various plant extracts is not particularly limited, and in the present embodiment, it is considered that the plant additives can directly act on the human body as a whole, and there is an intermediate action on the human body that can be added to other products as additives, and preferably, the various plant additives can be separated.
The material of the plant extract is not particularly limited, and any plant extract capable of playing the antibacterial and bacteriostatic actions should be included, and in the present embodiment, the plant extract is preferably selected from green tea extract, mint extract, emblic leafflower fruit extract, licorice extract and propolis extract.
The green tea extract is an active ingredient extracted from green tea leaves, and mainly comprises tea polyphenol (catechin) and the like. Has antibacterial, toxic materials removing, antioxidant, free radical scavenging, toxic materials clearing away, and immunity improving effects; the mint extract has fresh and pleasant fragrance; the fructus Phyllanthi extract has effects of scavenging free radicals and resisting oxidation; the Glycyrrhrizae radix extract has antiinflammatory, immunity resisting, heat and toxic materials clearing away, and skin whitening effects; the propolis extract has antibacterial, antiinflammatory, antipruritic, and antioxidant effects.
The plant extracts can be cooperated with each other, so that the effects of protection and health care can be more comprehensively achieved.
The formulation of the above plant extracts is not particularly limited, and includes powder, tablet, paste, etc., and in this example, the formulation is the same in consideration of easy packaging for uniform sale or easy metering for separate addition. The powder is more easily carried and added as an additive than other formulations, and therefore, in this embodiment, it is preferable to use the powder.
The bacteriostatic agent provided by the embodiment of the invention is prepared from the plant additive provided by the embodiment of the invention.
In the embodiment of the invention, the bacteriostatic agent can be sold after combining a plurality of plant extracts in the plant additive, or sold after independently packaging the plurality of plant extracts.
In the embodiment of the present invention, in order to improve the bacteriostatic effect, in the embodiment, the bacteriostatic agent preferably includes a green tea extract, a mint extract, an emblic leafflower fruit extract, a licorice extract, and a propolis extract.
It should be noted that the ratio and usage of the green tea extract, the mint extract, the emblic leafflower fruit extract, the licorice extract and the propolis extract are not specifically limited, and in this embodiment, in order to achieve the optimal antibacterial and bacteriostatic effects, the inventor has conducted creative tests to obtain, by weight, 0.5 to 5.5 parts of the green tea extract, 6.5 to 8.5 parts of the mint extract, 0.5 to 1.5 parts of the emblic leafflower fruit extract, 1.5 to 2.5 parts of the licorice extract and 0.5 to 5.5 parts of the propolis extract.
The inventor finds that the plant additive provided by the embodiment of the invention has good antibacterial and bacteriostatic effects, and has remarkable effects of preventing and treating gingival bleeding, repairing oral mucosa, eliminating oral odor and the like, so that the plant additive can be applied to the preparation of oral care products.
The oral care product provided by the embodiment of the invention is prepared from raw materials, and in order to obtain good oral care effects of treating gingival bleeding, repairing oral mucosa, resisting and inhibiting bacteria and the like, the raw materials comprise the plant additive provided by the embodiment of the invention.
the addition amount of the plant additive is not particularly limited, and in the embodiment of the present invention, the inventor has creatively tested that when the mass percentage of the plant additive in the raw material is 5.2% to 42%, the better oral health effect can be obtained, and especially when the mass percentage of the plant additive in the raw material is 6.5% to 42%, the best oral health effect can be obtained.
The manner of adding the plant additive to the raw materials is not particularly limited, and it is preferable that the plant extracts in the plant additive are weighed and then sequentially added in consideration of convenience in accurate weighing and calculation of the amount.
In this embodiment, the kind of the oral care product is not particularly limited, and toothpaste, mouthwash and mouth spray are preferably used in consideration of the high use rate of the prepared product.
When the oral care product is toothpaste, the inventor creatively tests out that the oral care product comprises the following raw materials in percentage by mass: the green tea extract 0.5-5%, the mint extract 2.5-5%, the emblic leafflower fruit extract 1.2-2%, the licorice extract 0.5-5% and the propolis extract 0.5-5% have the best oral health care effects of reducing gum bleeding and the like.
when the oral care product is mouthwash, creative tests of the inventor show that the oral care product comprises the following raw materials in percentage by mass: the green tea extract 1.5-3.5%, the mint extract 0.5-5%, the emblic leafflower fruit extract 2.5-3%, the licorice extract 1.5-5% and the propolis extract 0.5-5% have the best oral health care effects of refreshing breath and the like.
When the oral care product is oral spray, creative tests of the inventor show that the oral care product comprises the following raw materials in percentage by mass: the green tea extract 0.5-5%, the mint extract 2.5-5%, the emblic leafflower fruit extract 1.2-2%, the licorice extract 0.5-5% and the propolis extract 0.5-5% have the best effect of repairing oral mucosa and other oral health care effects.
The features and properties of the present invention are described in further detail below with reference to examples.
Examples 1 to 8
Examples 1-8 provide a bacteriostatic agent and a method for preparing the same, respectively.
Some of the formulations of the bacteriostats provided in examples 1-8 are shown in table 1 below:
TABLE 1
The preparation method of the bacteriostatic agent provided in examples 1-8 is as follows:
Respectively extracting green tea, herba Menthae, fructus Phyllanthi, Glycyrrhrizae radix and propolis with water and ethanol by ultrasonic extraction, performing sonic extraction at 15 deg.C, mixing the obtained green tea extract, herba Menthae extract, fructus Phyllanthi extract, Glycyrrhrizae radix extract and propolis extract in the above weight parts, and making into antibacterial agent.
Examples 9 to 16
Examples 9-16 provide a toothpaste and a method of making the same, respectively.
Some of the formulations of the toothpastes provided in examples 9-16 are shown in table 2 below:
TABLE 2
The preparation of the toothpastes provided in examples 9-16 is as follows:
The toothpaste is prepared from the weighed green tea extract, mint extract, emblic leafflower fruit extract, liquorice extract and propolis extract and a proper amount of grinding agent, humectant, adhesive, foaming agent, sweetener, essence and other components (preservative, pigment, water, efficacy additive and the like) according to a conventional method.
Examples 17 to 24
Examples 17-24 provide a mouthwash and a method of making the same, respectively.
Some of the formulations of the mouthwashes provided by examples 17-24 are shown in table 3 below:
TABLE 3
Examples 17-24 provide mouthwashes prepared as follows:
The green tea extract, the mint extract, the emblic extract, the liquorice extract and the propolis extract are weighed, and a proper amount of humectant, emulsifier, sweetener, essence and other components (preservative, pigment, water, functional additive and the like) are mixed to prepare the mouthwash according to a conventional method.
Examples 25 to 32
Examples 25-32 provide an oral spray and a method of making the same, respectively.
Some of the formulations of the oral sprays provided by examples 25-32 are shown in table 4 below:
TABLE 4
Examples 25-32 provide oral sprays prepared as follows:
Mixing the weighed green tea extract, herba Menthae extract, fructus Phyllanthi extract, Glycyrrhrizae radix extract and propolis extract with appropriate amount of humectant, emulsifier, flavoring agent, ethanol, sweetener, essence, and other components (antiseptic, pigment, water, and effect additive) and making into oral spray by conventional method.
Experimental example 1
(1) Killing effect of bacteriostatic agent on escherichia coli
Taking 16 LB culture media, putting the same amount of bacteriostatic agent prepared in the examples 1-8 into 8 culture media, setting the culture media into experimental groups 1-8 correspondingly, and setting the rest 8 culture media as control groups into control groups 1-8; coli was added to each of the experimental groups 1 to 8 and the control groups 1 to 8, and the total number of colonies in each medium was observed after 8 hours, as shown in Table 5.
(2) Killing effect of bacteriostatic agent on staphylococcus aureus
Taking 16 LB culture media, putting the same amount of bacteriostatic agent prepared in the examples 1-8 into 3 culture media, setting the culture media into experimental groups 1-8 correspondingly, and setting the rest 8 culture media as control groups into control groups 1-8; staphylococcus aureus was added to each of the experimental groups 1 to 8 and the control groups 1 to 8, and the total number of colonies in each medium was observed after 8 hours, as shown in Table 5.
TABLE 5
As can be seen from the data in table 5, the bacteriostatic agents prepared in examples 1 to 8 all showed significant killing effects on escherichia coli and staphylococcus, which indicates that at least three or more plant extracts provided in the examples of the present invention cooperate to achieve synergistic and synergistic effects in killing bacteria. Wherein, the killing effect on escherichia coli and staphylococcus in the examples 4-6 is better than that in the examples 1-3, which shows that the five plant extracts are matched with each other to play the optimal synergistic sterilization effect, and the sterilization capability is better than that of only three or four plant extracts; the killing effect on E.coli and staphylococci in examples 4-6 was better than that of examples 7-8, indicating that the bacteriostatic agents formulated within the scope of the data obtained inventively in the examples of the present invention gave the best results.
Experimental example 2
The toothpaste provided by the embodiment of the invention has the effect of improving gingival bleeding
Selecting 90 subjects with similar tooth health status, and dividing into 9 groups, wherein each group comprises 10 persons; the toothpastes provided in examples 9 to 16 (as experimental groups 1 to 8) were clinically verified together with a toothpaste without any functional ingredient (as control group 1) as a control; the mean gingival bleeding index BOP% of 9 groups of subjects using the same time period was compared, see table 6.
TABLE 6
| Sample (I) | BOP baseline value (%) | After one month | After three months |
| Experimental group 1 | 4.02 | 2.86 | 1.72 |
| Experimental group 2 | 4.03 | 2.78 | 1.65 |
| Experimental group 3 | 4.02 | 2.72 | 1.58 |
| Experimental group 4 | 4.01 | 2.56 | 1.09 |
| Experimental group 5 | 4.05 | 2.61 | 1.10 |
| experimental group 6 | 4.03 | 2.31 | 1.03 |
| Experimental group 7 | 4.05 | 2.88 | 1.36 |
| Experimental group 8 | 4.01 | 2.91 | 1.42 |
| Control group 1 | 4.02 | 3.36 | 2.65 |
As can be seen from the data in Table 6, the BOP% values of the subjects in the experimental groups 1-8 were significantly decreased after one month and three months, and were significantly better than those of the control group 1, which indicates that the toothpaste containing at least three plant extracts provided by the embodiments of the present invention can improve the gingival bleeding. Wherein, the BOP% values of the subjects of the experimental groups 4-6 after one month and three months were decreased by a ratio greater than that of the experimental groups 1-3, which indicates that the addition of five plant extracts more comprehensively improves the gingival bleeding symptom than the addition of three or four plant extracts improved according to the present example; the subjects in experimental group 5 had a greater percentage reduction in BOP% values after one and three months than in experimental group 4 and 6, indicating that the effect of improving gingival bleeding was best when the total amount of five plant extracts added was 6.5% to 42%; the subjects in experimental groups 4-6 had a greater percentage reduction in BOP% values after one and three months than in experimental groups 7-8, indicating that the range of ratios of the plant extracts inventively obtained according to the examples of the present invention when added to toothpaste provides the best results in terms of improvement of gingival bleeding.
Experimental example 3
The mouth wash provided by the embodiment of the invention has the effect of eliminating bad breath
Selecting 90 patients with halitosis of the same degree, and dividing into 9 groups, each group containing 10 patients; the mouthwashes provided in examples 17 to 24 (as experimental groups 1 to 8) were tested together with a mouthrinse without any additional efficacy ingredient (as control group 1) as a control; the improvement in oral cavity was compared in 9 groups of patients who used the same period of time, as shown in Table 7.
TABLE 7
| Sample (I) | Degree of mouth odor | After two weeks | After one month |
| Experimental group 1 | Severe severity of disease | Is obviously improved | Without breath |
| Experimental group 2 | severe severity of disease | Is obviously improved | Without breath |
| Experimental group 3 | Severe severity of disease | Is obviously improved | Without breath |
| Experimental group 4 | Severe severity of disease | Is obviously improved and almost has no bad breath | Breath freshening |
| Experimental group 5 | Severe severity of disease | Is obviously improved and almost has no bad breath | Breath freshening |
| Experimental group 6 | Severe severity of disease | Is obviously improved and almost has no bad breath | Breath freshening |
| Experimental group 7 | severe severity of disease | Is obviously improved | Without breath |
| Experimental group 8 | severe severity of disease | Is obviously improved | Without breath |
| Control group 1 | Severe severity of disease | Get slight improvement | Light breath |
As can be seen from the data in table 6, the breath degree of the patients with breath in experimental groups 1 to 8 was significantly improved after two weeks, the breath disappeared after one month, while the breath of the control group 1 was still not disappeared after one month, which indicates that the oral environment was significantly improved and the bad smell was removed by adding at least three kinds of the plant extracts provided in the embodiments of the present invention to the mouthwash. Wherein, compared with the experimental groups 1-3, the oral cavity of the patients of the experimental groups 4-6 become clear after one month, which shows that compared with the addition of three or four plant extracts improved by the embodiment of the invention, the addition of five plant extracts has better effects of improving the oral cavity environment and eliminating peculiar smell; the breath of the patients with the breath of the experimental groups 4 to 6 becomes clear after one month, compared with the breath of the experimental groups 7 to 8, on the basis of disappearance of the breath, which shows that the proportion range of the plant extract creatively obtained according to the embodiment of the invention is added into the mouthwash, so that the effects of improving the oral environment and eliminating the peculiar smell are better.
Experimental example 4
The oral spray provided by the embodiment of the invention has the function of restoring oral mucosa
Selecting 90 patients with oral mucosa ulceration of the same degree, dividing the patients into 9 groups, and 10 patients in each group; the oral sprays provided in examples 25-32 (as experimental groups 1-8) were tested with an oral spray without any efficacy ingredient (as control group 1) as a control; the oral mucosa repair was compared in 9 groups of patients after the same time period, see table 8.
TABLE 8
As can be seen from the data in table 8, the oral cavity ulceration degree of the oral cavity ulceration patients in the experimental groups 1 to 8 is obviously improved or even disappeared after two weeks, while the oral cavity ulceration degree of the control group 1 is still more important after two weeks, which indicates that the oral cavity spray can obviously repair the ulcerated part due to the addition of at least three plant extracts provided by the embodiments of the present invention. The patient of the experimental group 4-6 has better oral cavity ulceration repairing degree than the patient of the experimental group 1-3 after two weeks, which shows that compared with the addition of three or four plant extracts improved by the embodiment of the invention, the synergistic effect of the five plant extracts is better, and the oral cavity ulceration can be remarkably repaired; the oral cavity ulceration repairing degree of the oral cavity ulceration patients of the experimental groups 4-6 is better than that of the experimental groups 7-8 after two weeks, which shows that the effect of repairing the oral cavity ulceration is better when the plant extract creatively obtained according to the embodiment of the invention is added into the oral cavity spray in the proportioning range.
In conclusion, the bacteriostatic agent prepared from the plant composition provided by the embodiment of the invention has good bacteriostatic and bactericidal capabilities; the oral care product prepared by using the plant composition provided by the embodiment of the invention as an additive has excellent efficacies of relieving gingival bleeding, repairing oral mucosa, refreshing breath, eliminating peculiar smell and the like, and is suitable for being used when oral cavity problems occur and also suitable for being used for prevention in daily life.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (3)
1. An oral care product, which is a toothpaste and comprises the following raw materials in percentage by mass: 0.5 to 5 percent of green tea extract, 2.5 to 5 percent of mint extract, 1.2 to 2 percent of emblic leafflower fruit extract, 0.5 to 5 percent of liquorice extract and 0.5 to 5 percent of propolis extract.
2. An oral care product, which is a mouthwash and comprises the following raw materials in percentage by mass: 1.5 to 3.5 percent of green tea extract, 0.5 to 5 percent of mint extract, 2.5 to 3 percent of emblic leafflower fruit extract, 1.5 to 5 percent of liquorice extract and 0.5 to 5 percent of propolis extract.
3. An oral care product, which is an oral spray and comprises the following raw materials in percentage by mass: 0.5 to 5 percent of green tea extract, 2.5 to 5 percent of mint extract, 1.2 to 2 percent of emblic leafflower fruit extract, 0.5 to 5 percent of liquorice extract and 0.5 to 5 percent of propolis extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710188477.0A CN106924162B (en) | 2017-03-27 | 2017-03-27 | Plant additive, bacteriostatic agent, oral care product and application of plant additive in preparation of oral care product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710188477.0A CN106924162B (en) | 2017-03-27 | 2017-03-27 | Plant additive, bacteriostatic agent, oral care product and application of plant additive in preparation of oral care product |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106924162A CN106924162A (en) | 2017-07-07 |
| CN106924162B true CN106924162B (en) | 2019-12-06 |
Family
ID=59426623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710188477.0A Active CN106924162B (en) | 2017-03-27 | 2017-03-27 | Plant additive, bacteriostatic agent, oral care product and application of plant additive in preparation of oral care product |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106924162B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108498400A (en) * | 2018-05-23 | 2018-09-07 | 安徽广生堂生物科技有限公司 | The formula of one Plant Extracts mix preparation and its method for making cleaning agent for mouth cavity |
| CN110237241A (en) * | 2019-07-05 | 2019-09-17 | 广州康云生物科技有限公司 | A kind of compositions of additives containing lysozyme and plant extracts |
| CN112618451A (en) * | 2020-11-24 | 2021-04-09 | 云南云药医药研究有限公司 | Composition containing natural antibacterial ingredients and application |
| CN113197803B (en) * | 2021-04-29 | 2022-04-19 | 浙江吉叶生物科技有限公司 | Antibacterial mouth wash and preparation method thereof |
| CN113244155A (en) * | 2021-05-19 | 2021-08-13 | 广州冰泉化妆品科技有限公司 | Compound antibacterial mothproof mouthwash and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552082A (en) * | 2011-09-24 | 2012-07-11 | 云南龙润药业有限公司 | Toothpaste containing Phyllanthus emblica extracts |
| CN105476903A (en) * | 2015-12-11 | 2016-04-13 | 苏文清 | Folic acid toothpaste |
| CN105748398A (en) * | 2016-04-28 | 2016-07-13 | 浙江大学 | Oral care solution and preparation method thereof |
| CN106309331A (en) * | 2016-10-14 | 2017-01-11 | 柳州环山科技有限公司 | Mouth wash used in female physiological period and preparation method thereof |
-
2017
- 2017-03-27 CN CN201710188477.0A patent/CN106924162B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552082A (en) * | 2011-09-24 | 2012-07-11 | 云南龙润药业有限公司 | Toothpaste containing Phyllanthus emblica extracts |
| CN105476903A (en) * | 2015-12-11 | 2016-04-13 | 苏文清 | Folic acid toothpaste |
| CN105748398A (en) * | 2016-04-28 | 2016-07-13 | 浙江大学 | Oral care solution and preparation method thereof |
| CN106309331A (en) * | 2016-10-14 | 2017-01-11 | 柳州环山科技有限公司 | Mouth wash used in female physiological period and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106924162A (en) | 2017-07-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106924162B (en) | Plant additive, bacteriostatic agent, oral care product and application of plant additive in preparation of oral care product | |
| JP4246736B2 (en) | Composition for oral dental treatment of medicinal herbs and preparation method thereof | |
| CN107595750B (en) | Active anti-inflammation toothpaste | |
| CN107811890A (en) | A kind of oral cavity caring toothpaste composition | |
| KR102090119B1 (en) | Toothpaste composition comprising herbal extract mixture as effective component | |
| Almas et al. | Miswak (salvadora persica chewing stick) and its role in oral health; an update | |
| KR101251161B1 (en) | Composition of Toothpaste and Method of Preparing thereof | |
| CN105168086B (en) | Traditional Chinese medicine composition, compound particles containing traditional Chinese medicine composition, toothpaste and preparation method of toothpaste | |
| Sarkar et al. | Overview of the skeleton significance of toothpaste formulation, evaluation and historical perspectives: Insights from Bangladesh’s toothpaste industry | |
| Teke et al. | In vitro antimicrobial activity of some commercial toothpastes | |
| Topcuoglu et al. | Antibacterial effect of Kenger gum on mutans streptococci and its cytotoxic effect on the 3T3 fibroblast cell line. | |
| Ghelichli | Formulation of new herbal Salvadora toothpaste with antidecay, wound healing and caring tooth and Periodontal diseases | |
| KR100859967B1 (en) | Composites and preparation method of toothpaste containing extracts from Geum kang pine tree | |
| KR102196459B1 (en) | A toothpaste composition with improved antibacterial performance and a toothpaste comprising the composition | |
| KR101632910B1 (en) | Mouth spray composition comprising cypress extracts and medical herb extracts and manufacturing method thereof | |
| EP1683547A1 (en) | Anticaries toothpaste containing Rubus Fruticosus for treating and cleaning teeth and/or gums | |
| JP6291151B2 (en) | Oral composition | |
| KR20150040818A (en) | Oral Hygiene functional composition and a method of manufacturing | |
| KR101910716B1 (en) | Mouthwash containing green tea | |
| JP6574150B2 (en) | Oral composition | |
| Fareen et al. | Evaluation of antimicrobial activity of commercially available herbal toothpaste-An in vitro study. | |
| CN107362112A (en) | One kind shield gum healing toothpaste | |
| KR102090592B1 (en) | An oral composition for preventing dental calculus | |
| CN106726684A (en) | A kind of refrigerant mouthwash, preparation method and applications | |
| CN107510641A (en) | A kind of early dress toothpaste of American-cockroach-extract-containing and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A plant additive, antibacterial agent, oral care product, and the application of plant additives in the preparation of oral care products Effective date of registration: 20231225 Granted publication date: 20191206 Pledgee: Hua Xia Bank Co.,Ltd. Kunming Branch Pledgor: YUNNAN WEST GRASS RESOURCES DEVELOPMENT CO.,LTD. Registration number: Y2023980073832 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |