CN105476903A

CN105476903A - Folic acid toothpaste

Info

Publication number: CN105476903A
Application number: CN201510920614.6A
Authority: CN
Inventors: 苏文清
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-12-11
Filing date: 2015-12-11
Publication date: 2016-04-13

Abstract

The invention belongs to the field of daily chemical products and relates to a folic acid toothpaste, comprising materials of following parts by weight: 1-9 parts of Herba Perillae extract, 1-8 parts of Rhizoma Atractylodis Macrocephalae extract, 0-1 part, but not equal to 0, of Radix Scutellariae extract, 1-5 parts of green tea extract, 2-9 parts of folic acid and its derivatives, and 75-90 parts of ointment matrix. The folic acid toothpaste has the effects such as easing pain and stopping blood, subsiding swelling, inhibiting germs and subsiding inflammations, can be used to effectively prevent a pregnant woman from vomiting during tooth brushing and effectively control pregnancy gingivitis, pregnancy epulis, periodontitis, gingival atrophy, oral ulcers, bad breath, dental decay and the like, has a quick absorption function practiced by using oral sublingual mucosa and can promote the human body to absorb ingredients such as folic acid and give effects of the folic acid to play.

Description

Folic acid toothpaste

Technical field

The invention belongs to filed of daily-use chemical industry, relate to a kind of daily toothpaste, particularly relate to when one can effectively prevent anemia of pregnant woman from brushing teeth and vomit, effective prevention and pregnancy gingivitis of releiving, gestational epulis, periodontitis, and effectively realize Supplement of folic acid, and medicated toothpaste-anemia of pregnant woman's toothpaste of the disease such as decayed tooth, oral ulcer; The present invention also relates to the preparation technology of this toothpaste special for pregnant women simultaneously.

Background technology

Toothpaste is cleaning supplies conventional in daily life, has very long history.Along with the development of science and technology, technological equipment update and perfect, various types of toothpaste is come out one after another, quality and the class of product improve constantly, present toothpaste variety by single clean type toothpaste, develops into great variety of goods, diverse in function, the Mobyneb toothpaste of up to a hundred brands, meets the needs of different levels level of consumption.But, due to usually fluorine-containing in toothpaste, fluorine use is excessive easily causes fluorosis, therefore, common toothpaste with fluoride is not also suitable for the special population such as anemia of pregnant woman, baby, meanwhile, because the health that women's pregnancy period is special makes tooth paste product in the market can not meet comprehensive demand of pregnant women.

Anemia of pregnant woman selects the reactions such as food, inappetence, mild nausea, vomiting, dizziness, body be tired for about 6 weeks in gestation, is called morning sickness, also claims vomiting during pregnancy.Phenolics, anemia of pregnant woman vomits because of responsive, easily stimulates nauseant nerve when brushing teeth, very easily nauseating, vomiting.Cause a lot of anemia of pregnant woman to remove because of gestation reaction the process of brushing teeth from, like that only can increase the risk of periodontal, having had a strong impact on health and the mouth care of anemia of pregnant woman's tooth, is all disadvantageous to anemia of pregnant woman and fetus.

The gingivitis of phenolics refers to that gingiva is rubescent, swelling, hemorrhage, halitosis, and time serious, loosening appears in tooth, pain, drifting tooth, and a point puerperium symptom alleviates gradually or disappears.Therefore pregnancy gingivitis is referred to as again.Pregnancy gingivitis is the common a kind of oral disease of pregnant woman, and unfavorable to the physical and mental health of anemia of pregnant woman, the anemia of pregnant woman of the clinical 30%-100% of having is affected.

There is abnormal flavour in the common anemia of pregnant woman oral cavity of pregnancy duration, gingival hemorrhage, swelling, even forms epulis.Epulis or form periodontal pocket between swelling gingiva and tooth, wherein caulked food debris, is conducive to the nourishing breeding of bacterial micro-organism, affects health and the prenatal and postnatal care of anemia of pregnant woman.But nearly all anemia of pregnant woman worries, Drug therapy untoward reaction affects the normal development of fetus, and gingivitis can not effectively be controlled.Gingivitis is that anemia of pregnant woman changes due to endocrine the phasic Chang occurred in trimester of pregnancy.Trimester of pregnancy anemia of pregnant woman body inner estrogen and progesterone level all have increase, and progestogen can reduce the generation of collagen, and gingiva substrate is died down.Estrogen then can stimulate swelling and aching of gum.In Early placental phase anemia of pregnant woman body, chorionic-gonadotropin hormone obviously increases, and can affect the integrity of gingival epithelium tissue, and pregnancy gingivitis is the most serious before the pregnant 2-3 month and childbirth.

The reason that pregnant gingivitis occurs mainly affects by estrogen, corpus luteum hormone imbalance etc., and endocrine changes, and makes the metabolism of tissue influenced, thus have also been changed the reaction of gingiva to bacterial plaque.Dental health is good, and do not have local excitation, the inflammation of gingiva tissue will very gently or not occur.In addition, from parent, not only will absorb various nutrition phenolics fetus, also will absorb the various trace element such as calcium, phosphorus, ferrum of q.s from parent, especially will pay attention to supplementary calcium, phosphorus, vitamin D etc.If supplement not enough, the calcium in parent skeleton and tooth, will dissociate out enters blood, with the form of blood calcium supply fetus.Therefore, parent also can produce whole body osteoporosis, and decalcification phenomenon appears in tooth, reduces the acid resistance of tooth, very easily dental caries occurs.In view of this, phenolics and a period of time in puerperal carry out oral cavity health and are very important.

Gravidic first trimester is the important period that embryo's neurocele is grown, determine that embryo's neurocele grows the important period whether perfected, if the lower meeting of folate content causes embryo's neurocele developmental disorder in pregnant women body, this is a kind of lifelong participation disease, can only by preventing to be intervened in advance, and cannot treat after ill, once ill meeting causes repent forever to patient and family members thereof, therefore, the Supplement of folic acid of current pregnant women is also a vital task, existing comparatively general mode is oral YESUAN PIAN, pregnant women is needed to carry with medicine, and take on time, easily there is the phenomenon missed, be unfavorable for effectively supplementing of folic acid.

Toothpaste is articles for daily use indispensable during people live, and the quality of tooth also directly affects health; Medicated toothpaste is in the market of a great variety, differs from one another.But the toothpaste special for anemia of pregnant woman is few, the present invention is directed to anemia of pregnant woman's design, safety non-toxic, has no side effect, and effectively alleviates when anemia of pregnant woman brushes teeth and easily vomits situation, control pregnancy gingivitis, periodontitis, effective Supplement of folic acid, and prevents decayed tooth, the diseases such as anti-treating dental ulcer.

Summary of the invention

One is the object of the present invention is to provide to have preventing or arresting vomiting, pain relieving, hemostasis, detumescence, antibacterial, antiinflammatory, Supplement of folic acid, antiallergic, the folic acid toothpaste of whitening function.

For this reason, the invention provides a kind of folic acid toothpaste, the raw material comprising following weight portion of described folic acid toothpaste: Folium perillae extract 1-9 part; Rhizoma Atractylodis Macrocephalae extract 1-8 part; Radix Scutellariae extract 0-1 part, and be not equal to 0; Green tea extract 1-5 part; Folic acid and derivant 2-9 part thereof; Ointment is with substrate 75-90 part.

Preferably, described folic acid toothpaste, the raw material comprising following weight portion of described folic acid toothpaste: Folium perillae extract 3-6 part; Rhizoma Atractylodis Macrocephalae extract 3-5 part; Radix Scutellariae extract 0.2-0.8 part; Green tea extract 2-4 part; Folic acid and derivant 4-6 part thereof; Ointment is with substrate 80-85 part.

Preferably, described folic acid toothpaste, the raw material comprising following weight portion of described folic acid toothpaste: Folium perillae extract 5 parts; Rhizoma Atractylodis Macrocephalae extract 4 parts; Radix Scutellariae extract 0.5 part; Green tea extract 3 parts; Folic acid and derivant 5 parts thereof; Ointment substrate 83 parts.

Preferably, described folic acid toothpaste, described folic acid toothpaste also comprises the raw material of following weight portion:

Preferably, described folic acid toothpaste, described folic acid toothpaste comprises the raw material of following weight portion:

Preferably, described folic acid toothpaste, to be weight percentage benchmark with matrix weight, described substrate comprises:

Abrasivus 15%-50%;

Sweeting agent 0-1%;

Foaming agent 1%-5%;

Adhesive 0.5%-3%;

Wetting agent 5%-30%;

Spice 0-2%;

Antiseptic 0-0.5%;

Deionized water 2%-40%;

Food coloring 0-1.5%.

Preferably, described folic acid toothpaste, described abrasivus fineness is moderate, pH value is 7.5-9, free from admixture, be selected from calcium carbonate, calcium phosphate dibasic dihydrate, calcium phosphate dibasic anhydrous, calcium pyrophosphate, anhydride silica, aluminium hydroxide, Alumina hydrate, calcite in powder, leuchtenbergite, the granularity of described abrasivus is 5-40 μm, and Mohs' hardness is 2-4 degree;

Described sweeting agent is selected from sucrose, glucide, cyclamate, xylitol, dipeptide sodium;

Described foaming agent has foaming decontamination, is selected from sodium lauryl sulphate, N-sodium lauroyl sarcosine, methyl cocoa ester group sodium taurocholate, acyl glutamic acid sodium;

Described adhesive is primary raw material, and pH value is 8, and its consumption is directly proportional to abrasivus, is selected from sodium alginate, carboxymethyl cellulose, hydroxyethyl-cellulose, yellow gummy powder, hydroxypropyl guar gum;

Described wetting agent has water suction antifreeze and ensure that mastic displays rear indeformable effect, is selected from glycerol, sorbitol, propylene glycol, Polyethylene Glycol;

Described spice is for can make people's feeling cool tasty and refreshing, and the major ingredient of fragrant odour, is selected from lemon sesame oil, Oleum Menthae Rotundifoliae, orange oil, mandarin oil, wintergreen oil, Oleum Anisi Stellati, Borneolum Syntheticum, citral, lauryl aldehyde, vanillin, pentyl acetate;

Described antiseptic is selected from p-Hydroxybenzoate, sodium benzoate, potassium sorbate, sorbitol;

Described deionized water is the plastic disperse medium of toothpaste; Described food coloring is green and purple.

Preferably, described folic acid toothpaste, described abrasivus is calcium carbonate or calcium phosphate dibasic dihydrate; Described sweeting agent is sucrose or xylitol; Described foaming agent is sodium lauryl sulphate; Described adhesive is carboxymethyl cellulose; Described wetting agent is glycerol; Described antiseptic is sorbitol.

Preferably, in described folic acid toothpaste,

Described Folium perillae extract is that pulverize, water extraction or alcohol extraction, be condensed into extractum or Folium Perillae volatile oil component that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Folium Perillae medical material removing impurity;

Described Rhizoma Atractylodis Macrocephalae extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Rhizoma Atractylodis Macrocephalae removing impurity;

Described Radix Scutellariae extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected radix scutellariae medicinal materials removing impurity;

Described green tea extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected green tea medical material removing impurity.

Preferably, described folic acid toothpaste,

Described notoginseng extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Radix Notoginseng medical material removing impurity;

Described Radix Glycyrrhizae extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected licorice medicinal materials removing impurity;

Described Flos Lonicerae extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Chinese medicine honeysuckle removing impurity;

Described Flos Sophorae extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Flos Sophorae medical material removing impurity;

Described Folium Menthae extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Herba Menthae medical material removing impurity;

Described Fructus Fragariae Ananssae extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Fructus Fragariae Ananssae removing impurity;

Described Flos Inulae extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Flos Inulae medical material removing impurity;

Described Flos Chrysanthemi extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Flos Chrysanthemi medical material removing impurity;

Described Olive leaf P.E is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Folium olive medical material removing impurity;

Described Cortex Cinnamomi extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Cortex Cinnamomi medical material removing impurity.

Folium Perillae is the dry stem of Labiatae Folium Perillae Perillafrutescens (L) Britt, has another name called Huis Soviet Union, red Soviet Union, purple Soviet Union, red Soviet Union, Fructus Perillae etc.Have special fragrance, China's cultivation is extremely wide, is mainly used in medicinal, oil use, spice, the aspect such as edible, its leaf, stalk, really all can be used as medicine, and tender leaf can be eaten raw, cook soup, and stem and leaf can be pickled.Being used as medicine, it is warm in nature, acrid in the mouth, and can induce sweat cold expelling, relieving QI stagnancy in the stomach, rushes down the diseases such as poisoning for anemofrigid cold, cough vomiting and nausea, vomiting during pregnancy, fish.Modern pharmacological research shows: Folium Perillae also has antibacterial, antiviral, blood pressure lowering, blood fat reducing, suppresses platelet aggregation, antithrombotic, defying age, fat-reducing, anti-allergic inflammation, enhancing learning and memory, function such as prevention canceration and inhibition tumor cell transfer etc.For many years, Folium Perillae is widely used in medicine, food with its integration of edible and medicinal herbs.Because Folium Perillae (stalk) medical material has regulating the flow of QI to ease the stomach, pain relieving, antiabortive effect, also has antibacterial, antiviral, blood pressure lowering, blood fat reducing, suppresses platelet aggregation, antithrombotic, defying age, fat-reducing, anti-allergic inflammation; The Rhizoma Atractylodis Macrocephalae can invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, and antiabortive, for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, and frequent fetal movement can be used for again antiabortive, controls the diseases such as gestation foot is swollen, nausea is uneasy; Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, heat-damp in summer, vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, lung-heat coughs element, high hot excessive thirst, and heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement; With the extract of Folium Perillae (stalk), the Rhizoma Atractylodis Macrocephalae, Radix Scutellariae, vitamin B6 be sole active pharmaceutical composition be prepared from folic acid toothpaste, vomiting when can prevent anemia of pregnant woman from brushing teeth, at prevention and pregnancy gingivitis of releiving, periodontitis, and decayed tooth, oral ulcer, the aspects such as mouth care have significant effect.

The Rhizoma Atractylodis Macrocephalae is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae AtractylodesmacrocephalaKoidz..Have another name called mountain Ji, poplar robe Ji, yellor rocket, sky Ji, Alpinia japonica (Thunb.) Miq., QI LI JIA, Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis Macrocephalae, the winter Rhizoma Atractylodis Macrocephalae, white birthday etc., property is bitter, sweet, temperature.Return spleen, stomach warp.Be mainly used in invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.

1., for weakness of the spleen and stomach, lack of appetite distension, fatigue and weakness, has loose bowels.Tonifying the spleen and stomach can with the compatibility such as Radix Codonopsis, Radix Glycyrrhizae; The painful abdominal mass that disappears de-swelling can be equal to Fructus Aurantii to be used; The spleen strengthening and damp drying antidiarrheal can be equal to Pericarpium Citri Reticulatae, Poria to be used.

2. for water-damp retention, phlegm retention, edema.Control cold fluid-retention can with the compatibility such as Poria, Ramulus Cinnamomi; Harnessing the river swells often to be equal to Cortex Sclerotii Poriae, Pericarpium Arecae uses.

3. for exterior deficiency spontaneous perspiration.This product is equal to use with the Radix Astragali, Fructus Tritici Levis, has the merit of strengthening superficial resistance to stop perspiration, can control exterior deficiency spontaneous perspiration.

In addition, this product can be used for again antiabortive, controls the diseases such as gestation foot is swollen, nausea is uneasy, the person that has interior-heat, can with the compatibility such as Radix Scutellariae; Soreness of waist person can be equal to the Cortex Eucommiae, Herba Taxilli and uses.The Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement." medicine origin " is recorded: " dehumidifying benefit is dry, and middle QI invigorating, warming middle-JIAO, go in taste wet, except gastric heat, strong taste, enter diet, quench the thirst, antiabortive.”

" the deficient Chinese angelica powder opinion of danxi's experiential therapy gold " of " the Radix Scutellariae Rhizoma Atractylodis Macrocephalae is antiabortive panacea "-come from ZHU Dan-xi.

Radix Scutellariae is the dry root of labiate Radix Scutellariae ScutellariabaicalensisGeorgi.Conically, distortion, long 8 ~ 25cm, diameter 1 ~ 3cm.Surface brown color or buff, have sparse excipuliform radicula trace, top is more coarse, and have the vertical wrinkle of distortion or irregular reticulate pattern, rift grain and scabriculous are arranged at bottom.Matter is hard and crisp, frangibility, and section is yellow, and middle rufous, is generally called sub-a kind of reed mentioned in ancient books, based on yin nourishing of relieving inflammation or internal heat; In burgundy or brownish black in the middle of old root, dry and decayed shape or become cavity, claims Radix Scutellariae, relieves internal heat to relieve inflammation or internal heat.Feeble QI, bitter in the mouth.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Function heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.Radix Scutellariae is also usually used in treating gynecological disorders, has the function of clearing heat and preventing abortion, can control the frequent fetal movement that heat is very caused, habitual abortion.Control the effects such as vomiting during pregnancy.

Vitamin B6 (VitaminB6) is also known as pyridoxin, and a kind of vitamin B group containing pyridoxol or 2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine. or pyridoxamine, it is water soluble vitamins, meets light or alkali destructible, non-refractory.Vitamin B6 is clear crystal, soluble in water and ethanol, and stable in acid solution, destructible in alkali liquor, pyridoxol is heat-resisting, 2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine. and pyridoxamine non-refractory.Vitamin B6 content in yeast, liver, grain, meat, fish, egg, beans and Semen arachidis hypogaeae is more.Vitamin B6 is the constituent of some coenzyme in human body, participates in multiple metabolic response, especially has substantial connection with amino acid metabolism.Apply Vitamin B6 preparation control vomiting during pregnancy and radiation sickness vomiting clinically.

Except above-mentioned Chinese crude drug, also can add Rhizoma Zingiberis Recens, Fructus Citri Sarcodactylis, Radix Ophiopogonis, Radix Rehmanniae, Caulis Bambusae In Taenia, Fructus Amomi, Herba Taxilli, the Cortex Eucommiae, Radix Dipsaci, Radix Boehmeriae, Folium Artemisiae Argyi, Semen Cuscutae, Colla Corii Asini, Rhizoma Acori Graminei, Fructus Vitis viniferae, Fructus Citri Limoniae etc. in toothpaste of the present invention in order to prevent vomiting during pregnancy, control pregnancy gingivitis and to anemia of pregnant woman's all medicinal substances extract active component without any side effects.With extract, the common conduct of the vitamin B6 mainly pharmaceutically active substance of Folium Perillae (stalk), the Rhizoma Atractylodis Macrocephalae, radix scutellariae medicinal materials, various efficacy of drugs is made to produce synergism, thus more effectively prevent and treat gestational gingival hemorrhage, gingivitis, periodontitis, the disease such as gingival atrophy and oral ulcer, utilizes oral cavity hypoglossis mucous membrane to have the function absorbed fast simultaneously, promote that human body is to the absorption of the compositions such as folic acid, plays folic acid effect.

Detailed description of the invention

Prepared by raw material:

Described Folium perillae extract is that pulverize, water extraction or alcohol extraction, be condensed into extractum or Folium Perillae volatile oil component that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Folium Perillae medical material removing impurity.

Described Rhizoma Atractylodis Macrocephalae extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Rhizoma Atractylodis Macrocephalae removing impurity.

Described Radix Scutellariae extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected radix scutellariae medicinal materials removing impurity.

Described notoginseng extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Radix Notoginseng medical material removing impurity.

Described Radix Glycyrrhizae extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected licorice medicinal materials removing impurity.

Described Flos Lonicerae extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Chinese medicine honeysuckle removing impurity.

Described Flos Sophorae extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Flos Sophorae medical material removing impurity.

Described Folium Menthae extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Herba Menthae medical material removing impurity.

Described Fructus Fragariae Ananssae extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Fructus Fragariae Ananssae removing impurity.

Described Flos Inulae extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Flos Inulae medical material removing impurity.

Described Flos Chrysanthemi extract is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Flos Chrysanthemi medical material removing impurity.

Described Olive leaf P.E is that pulverize, water extraction or alcohol extraction, be condensed into the extractum that relative density is 1.10-1.30 after concentrated solution activated carbon decolorizing by selected Folium olive medical material removing impurity.

Toothpaste substrate: be commercially available prod.

Embodiment 1

Take Folium perillae extract 1g, Rhizoma Atractylodis Macrocephalae extract 8g, Radix Scutellariae extract 0.1g, green tea extract 5g, folic acid and derivant 2g thereof, calcium carbonate 45g, dipeptide sodium 0.9g, sodium lauryl sulphate 0.9g, sodium alginate 2.7g, Polyethylene Glycol 4.5g, lemon sesame oil 1.8g, deionized water 32.85g, non-polluted edible pigment 1.35g, mix homogeneously, is placed in after vacuum Manufacturing medicine extract machine carries out homogenizing process, fill and get final product.

Embodiment 2

Take Folium perillae extract 9g, Rhizoma Atractylodis Macrocephalae extract 1g, Radix Scutellariae extract 1g; green tea extract 1g, folic acid and derivant 9g thereof, leuchtenbergite 11.25g; acyl glutamic acid sodium 3.75g, hydroxypropyl guar gum 1.875g, glycerol 26.25g; pentyl acetate 1.5g; p-Hydroxybenzoate 0.375g, deionized water 30g, mix homogeneously; be placed in after vacuum Manufacturing medicine extract machine carries out homogenizing process, fill and get final product.

Embodiment 3

Take Folium perillae extract 3g, Rhizoma Atractylodis Macrocephalae extract 5g, Radix Scutellariae extract 0.2g, green tea extract 4g, folic acid and derivant 4g thereof, ointment substrate 85g, calcium phosphate dibasic anhydrous 42.5g, cyclamate 0.85g, N-sodium lauroyl sarcosine 4.25g, yellow gummy powder 2.55g, sorbitol 29.75g, Oleum Menthae Rotundifoliae 1.7g, sodium benzoate 0.425g, deionized water 1.7g, non-polluted edible pigment 1.275g, mix homogeneously, is placed in after vacuum Manufacturing medicine extract machine carries out homogenizing process, fill and get final product.

Embodiment 4

Take Folium perillae extract 6g, Rhizoma Atractylodis Macrocephalae extract 3g, Radix Scutellariae extract 0.8g; green tea extract 2g, folic acid and derivant 6g thereof, calcite in powder 28g; glucide 0.4g, methyl cocoa ester group sodium taurocholate 2.4g, carboxymethyl cellulose 0.4g; propylene glycol 20g, vanillin 0.8g, potassium sorbate 0.24g; deionized water 26.96g, purple food coloring 0.8g, mix homogeneously; be placed in after vacuum Manufacturing medicine extract machine carries out homogenizing process, fill and get final product.

Embodiment 5

Take Folium perillae extract 5g, Rhizoma Atractylodis Macrocephalae extract 4g, Radix Scutellariae extract 0.5g, green tea extract 3g, folic acid and derivant 5g thereof, ointment substrate 83g, calcium pyrophosphate 41.5g, xylitol 0.83g, sodium lauryl sulphate 4.15g, hydroxyethyl-cellulose 2.49g, sorbitol 24.9g, lauryl aldehyde 1.66g, potassium sorbate 0.415g, deionized water 5.81g, non-polluted edible pigment 1.245g, mix homogeneously, is placed in after vacuum Manufacturing medicine extract machine carries out homogenizing process, fill and get final product.

Embodiment 6

Take Folium perillae extract 1g, Rhizoma Atractylodis Macrocephalae extract 8g, Radix Scutellariae extract 0.1g, green tea extract 5g, folic acid and derivant 2g thereof, notoginseng extract 1g, Radix Glycyrrhizae extract 10g, Flos Lonicerae extract 1g, Flos Sophorae extract 4g, Folium Menthae extract 0.1g, Fructus Fragariae Ananssae extract 4g, Flos Inulae extract 2g, Flos Chrysanthemi extract 6g, Olive leaf P.E 2g, Oleum lavandula angustifolia quintessence oil 1g, Oleum Caryophylli 0.1g, Eucalyptus oil 2g, thyme oil 2g, Cortex Cinnamomi extract 6g, vitamin B6 0.1g, vitamin D1 0g, ointment substrate 90g, mix homogeneously, be placed in after vacuum Manufacturing medicine extract machine carries out homogenizing process, fill and get final product.Wherein said ointment substrate is become to be grouped into by following: Alumina hydrate 15%, sucrose 1%, methyl cocoa ester group sodium taurocholate 5%; hydroxypropyl guar gum 3%, Polyethylene Glycol 35%, orange oil 2%; sorbitol 0.5%, deionized water 37%, purple food coloring 1.5%.

Embodiment 7

Take Folium perillae extract 9g, Rhizoma Atractylodis Macrocephalae extract 1g, Radix Scutellariae extract 1g, green tea extract 1g, folic acid and derivant 9g thereof, notoginseng extract 8g, Radix Glycyrrhizae extract 1g, Flos Lonicerae extract 4g, Flos Sophorae extract 2g, Folium Menthae extract 1g, Fructus Fragariae Ananssae extract 2g, Flos Inulae extract 8g, Flos Chrysanthemi extract 2g, Olive leaf P.E 6g, Oleum lavandula angustifolia quintessence oil 0.1g, Oleum Caryophylli 1g, Eucalyptus oil 1g, thyme oil 6g, Cortex Cinnamomi extract 2g, vitamin B6 2g, vitamin D1 g, ointment substrate 75g, mix homogeneously, be placed in after vacuum Manufacturing medicine extract machine carries out homogenizing process, fill and get final product.Wherein said ointment substrate is become to be grouped into by following: anhydride silica 50%, glucide 0.5%, acyl glutamic acid sodium 1%; yellow gummy powder 0.5%, glycerol 5%, citral 2%; p-Hydroxybenzoate 0.5%, deionized water 39%, purple food coloring 1.5%.

Embodiment 8

Take Folium perillae extract 3g, Rhizoma Atractylodis Macrocephalae extract 5g, Radix Scutellariae extract 0.2g, green tea extract 4g, folic acid and derivant 4g thereof, notoginseng extract 8g, Radix Glycyrrhizae extract 1g, Flos Lonicerae extract 4g, Flos Sophorae extract 2g, Folium Menthae extract 1g, Fructus Fragariae Ananssae extract 2g, Flos Inulae extract 8g, Flos Chrysanthemi extract 2g, Olive leaf P.E 6g, Oleum lavandula angustifolia quintessence oil 0.1g, Oleum Caryophylli 1g, Eucalyptus oil 1g, thyme oil 6g, Cortex Cinnamomi extract 2g, vitamin B6 2g, vitamin D1 g, ointment substrate 85g, mix homogeneously, be placed in after vacuum Manufacturing medicine extract machine carries out homogenizing process, fill and get final product.Wherein said ointment substrate is become to be grouped into by following: aluminium hydroxide 45%, cyclamate 1%, N-sodium lauroyl sarcosine 1%, yellow gummy powder 3%, sorbitol 30%, mandarin oil 1%, sodium benzoate 0.5%, deionized water 17.5%, non-polluted edible pigment 1%.

Embodiment 9

Take Folium perillae extract 6g, Rhizoma Atractylodis Macrocephalae extract 3g, Radix Scutellariae extract 0.8g, green tea extract 2g, folic acid and derivant 6g thereof, notoginseng extract 1g, Radix Glycyrrhizae extract 10g, Flos Lonicerae extract 1g, Flos Sophorae extract 4g, Folium Menthae extract 0.1g, Fructus Fragariae Ananssae extract 4g, Flos Inulae extract 2g, Flos Chrysanthemi extract 6g, Olive leaf P.E 2g, Oleum lavandula angustifolia quintessence oil 1g, Oleum Caryophylli 0.1g, Eucalyptus oil 2g, thyme oil 2g, Cortex Cinnamomi extract 6g, vitamin B6 0.1g, vitamin D1 0g, ointment substrate 80g, mix homogeneously, be placed in after vacuum Manufacturing medicine extract machine carries out homogenizing process, fill and get final product.Wherein said ointment substrate is become to be grouped into by following: calcium pyrophosphate 15.4%, glucide 0.1%, methyl cocoa ester group sodium taurocholate 3%; carboxymethyl cellulose 3%, propylene glycol 35%, Borneolum Syntheticum 2%; potassium sorbate 0.5%, deionized water 40%, purple food coloring 1%.

Embodiment 10

Take Folium perillae extract 5g, Rhizoma Atractylodis Macrocephalae extract 4g, Radix Scutellariae extract 0.5g, green tea extract 3g, folic acid and derivant 5g thereof, notoginseng extract 5g, Radix Glycyrrhizae extract 5g, Flos Lonicerae extract 2.5g, Flos Sophorae extract 2.5g, Folium Menthae extract 0.5g, Fructus Fragariae Ananssae extract 3g, Flos Inulae extract 5g, Flos Chrysanthemi extract 4g, Olive leaf P.E 4g, Oleum lavandula angustifolia quintessence oil 0.5g, Oleum Caryophylli 0.5g, Eucalyptus oil 1.5g, thyme oil 4g, Cortex Cinnamomi extract 4g, vitamin B6 1g, Vitamin D5. g, ointment substrate 83g, mix homogeneously, be placed in after vacuum Manufacturing medicine extract machine carries out homogenizing process, fill and get final product.Wherein said ointment substrate is become to be grouped into by following: (granularity is 25 μm to calcium phosphate dibasic dihydrate; Mohs' hardness is 3 degree) 30%; glucide 0.5%; acyl glutamic acid sodium 3%, yellow gummy powder 2%, glycerol 35%; Oleum Anisi Stellati 1%; p-Hydroxybenzoate 0.25%, deionized water 27.25%, purple food coloring 1%.

Embodiment 11

Take Folium perillae extract 4g, Rhizoma Atractylodis Macrocephalae extract 6g, Radix Scutellariae extract 0.2g, green tea extract 4g, folic acid and derivant 3g thereof, notoginseng extract 2g, Radix Glycyrrhizae extract 8g, Flos Lonicerae extract 2g, Flos Sophorae extract 3.8g, Folium Menthae extract 0.2g, Fructus Fragariae Ananssae extract 3.8g, Flos Inulae extract 4g, Flos Chrysanthemi extract 5g, Olive leaf P.E 3g, Oleum lavandula angustifolia quintessence oil 0.8g, Oleum Caryophylli 0.1g, Eucalyptus oil 1.9g, thyme oil 2.5g, Cortex Cinnamomi extract 5g, folic acid and phase derivant 0.3g, vitamin B6 1.8g, vitamin D 8g, ointment substrate 87g, mix homogeneously, be placed in after vacuum Manufacturing medicine extract machine carries out homogenizing process, fill and get final product.Wherein said ointment substrate is become to be grouped into by following: (granularity is 5 μm to calcium phosphate dibasic dihydrate; Mohs' hardness is 4 degree) 32%; glucide 1%; acyl glutamic acid sodium 5%, yellow gummy powder 3%, glycerol 20%; wintergreen oil 2%; p-Hydroxybenzoate 0.5%, deionized water 35%, purple food coloring 1.5%.

Embodiment 12

Take Folium perillae extract 7g, Rhizoma Atractylodis Macrocephalae extract 2g, Radix Scutellariae extract 0.6g, green tea extract 2g, folic acid and derivant 8g thereof, notoginseng extract 4g, Radix Glycyrrhizae extract 4g, Flos Lonicerae extract 3g, Flos Sophorae extract 2.6g, Folium Menthae extract 0.7g, Fructus Fragariae Ananssae extract 2.2g, Flos Inulae extract 7g, Flos Chrysanthemi extract 3g, Olive leaf P.E 5g, Oleum lavandula angustifolia quintessence oil 0.2g, Oleum Caryophylli 0.7g, Eucalyptus oil 1.3g, thyme oil 5g, Cortex Cinnamomi extract 3g, folic acid and phase derivant 1.7g, vitamin B6 0.2g, vitamin D 8g, ointment substrate 78g, mix homogeneously, be placed in after vacuum Manufacturing medicine extract machine carries out homogenizing process, fill and get final product.Wherein said ointment substrate is become to be grouped into by following: (granularity is 40 μm to calcium carbonate, Mohs' hardness is 2 degree) 20%, sucrose or xylitol 1%, sodium lauryl sulphate 3%, carboxymethyl cellulose 3%, glycerol 30%, Oleum Anisi Stellati 2%, sorbitol 0.5%, deionized water 40%, non-polluted edible pigment 0.5%.

Embodiment 13

Take Folium perillae extract 5g, Rhizoma Atractylodis Macrocephalae extract 4g, Radix Scutellariae extract 0.4g, green tea extract 3g, folic acid and derivant 4.5g thereof, notoginseng extract 3g, Radix Glycyrrhizae extract 6g, Flos Lonicerae extract 2.5g, Flos Sophorae extract 3.3g, Folium Menthae extract 0.5g, Fructus Fragariae Ananssae extract 3g, Flos Inulae extract 5g, Flos Chrysanthemi extract 4g, Olive leaf P.E 4g, Oleum lavandula angustifolia quintessence oil 0.5g, Oleum Caryophylli 0.4g, Eucalyptus oil 1.5g, thyme oil 3.5g, Cortex Cinnamomi extract 4g, folic acid and phase derivant 1g, vitamin B6 1g, Vitamin D5. g, ointment substrate 80g, mix homogeneously, be placed in after vacuum Manufacturing medicine extract machine carries out homogenizing process, fill and get final product.Wherein said ointment substrate is become to be grouped into by following: calcium carbonate 20%, xylitol 1%, sodium lauryl sulphate 5%, carboxymethyl cellulose 0.5%, glycerol 35%, Oleum Anisi Stellati 2%, sorbitol 0.5%, deionized water 35%, non-polluted edible pigment 1%.

Embodiment 14

Take Folium perillae extract 6g, Rhizoma Atractylodis Macrocephalae extract 4g, Radix Scutellariae extract 0.4g, green tea extract 3g, folic acid and derivant 5.5g thereof, notoginseng extract 3g, Radix Glycyrrhizae extract 6g, Flos Lonicerae extract 2.5g, Flos Sophorae extract 3.2g, Folium Menthae extract 0.4g, Fructus Fragariae Ananssae extract 3g, Flos Inulae extract 4g, Flos Chrysanthemi extract 4g, Olive leaf P.E 4g, Oleum lavandula angustifolia quintessence oil 0.5g, Oleum Caryophylli 0.4g, Eucalyptus oil 1.6g, thyme oil 4g, Cortex Cinnamomi extract 4g, folic acid and phase derivant 1g, vitamin B6 1g, Vitamin D5. g, ointment substrate 81g, mix homogeneously, be placed in after vacuum Manufacturing medicine extract machine carries out homogenizing process, fill and get final product.Wherein said ointment substrate is become to be grouped into by following: calcium phosphate dibasic dihydrate 30%, sucrose 1%, sodium lauryl sulphate 1%, carboxymethyl cellulose 0.5%, glycerol 35%, Oleum Anisi Stellati 1%, deionized water 30%, non-polluted edible pigment 1.5%.

Experimental example

Investigate folic acid toothpaste prepared by embodiments of the invention 14 to pregnancy gingivitis, periodontitis, and the disease such as decayed tooth, oral ulcer there is control and the therapeutical effect such as to releive, and is confirmed by following clinical observation.Following table is the clinical observation statistical table of folic acid toothpaste of the present invention.

Patient age 20-38 year, wherein primipara 500 example, multipara 134 example.Symptoms of emesis when all patients all brush teeth.After using folic acid toothpaste of the present invention, symptoms of emesis alleviates all to some extent or alleviates.

Note: same patient can exist multiple disease simultaneously, therefore, the number that total number of persons is greater than actual participation test is normal phenomenon.

Folic acid toothpaste of the present invention, every day uses sooner or later, and toothpaste should stop the slightly longer time compared with ordinary toothpaste in oral cavity, and especially the periodontal time of staying of cacodontia more needs long.As can be seen from the above table, folic acid toothpaste of the present invention has pain easing and hemostasis, detumescence, the effects such as anti-inflammation, can be used for vomiting when effectively preventing anemia of pregnant woman from brushing teeth, effectively prevent and treat pregnancy gingivitis, gestational epulis, periodontitis, gingival atrophy, oral ulcer, halitosis and dental caries etc., utilize oral cavity hypoglossis mucous membrane to have the function absorbed fast simultaneously, promote that human body is to the absorption of the compositions such as folic acid, plays folic acid effect.After using one week, above-mentioned symptom obviously improves, and pregnancy and puerperium uses, without any side effects, and can be used for keeping oral cavity cleaning, pre-preventing tooth diseases occurs, and impels dental health.

Obviously, above-described embodiment is only for clearly example being described, and the restriction not to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.And thus the apparent change of extending out or variation be still among the protection domain of the invention.

Claims

1. a folic acid toothpaste, is characterized in that, the raw material comprising following weight portion of described folic acid toothpaste: Folium perillae extract 1-9 part; Rhizoma Atractylodis Macrocephalae extract 1-8 part; Radix Scutellariae extract 0-1 part, and be not equal to 0; Green tea extract 1-5 part; Folic acid and derivant 2-9 part thereof; Ointment is with substrate 75-90 part.

2. folic acid toothpaste according to claim 1, is characterized in that, the raw material comprising following weight portion of described folic acid toothpaste: Folium perillae extract 3-6 part; Rhizoma Atractylodis Macrocephalae extract 3-5 part; Radix Scutellariae extract 0.2-0.8 part; Green tea extract 2-4 part; Folic acid and derivant 4-6 part thereof; Ointment is with substrate 80-85 part.

3. folic acid toothpaste according to claim 1 and 2, is characterized in that, the raw material comprising following weight portion of described folic acid toothpaste: Folium perillae extract 5 parts; Rhizoma Atractylodis Macrocephalae extract 4 parts; Radix Scutellariae extract 0.5 part; Green tea extract 3 parts; Folic acid and derivant 5 parts thereof; Ointment substrate 83 parts.

4. the folic acid toothpaste according to any one of claim 1-3, is characterized in that, described folic acid toothpaste also comprises the raw material of following weight portion:

5. folic acid toothpaste according to claim 4, is characterized in that: described folic acid toothpaste comprises the raw material of following weight portion:

6. the folic acid toothpaste as described in any one of claim 1-5, is characterized in that: to be weight percentage benchmark with matrix weight, described substrate comprises:

Abrasivus 15%-50%;

Sweeting agent 0-1%;

Foaming agent 1%-5%;

Adhesive 0.5%-3%;

Wetting agent 5%-35%;

Spice 0-2%;

Antiseptic 0-0.5%;

Deionized water 2%-40%;

Food coloring 0-1.5%.

7. folic acid toothpaste according to claim 6, is characterized in that:

Described abrasivus fineness is moderate, pH value is 7.5-9, free from admixture, be selected from calcium carbonate, calcium phosphate dibasic dihydrate, calcium phosphate dibasic anhydrous, calcium pyrophosphate, anhydride silica, aluminium hydroxide, Alumina hydrate, calcite in powder, leuchtenbergite, the granularity of described abrasivus is 5-40 μm, and Mohs' hardness is 2-4 degree;

8. folic acid toothpaste according to claim 7, is characterized in that: described abrasivus is calcium carbonate or calcium phosphate dibasic dihydrate; Described sweeting agent is sucrose or xylitol; Described foaming agent is sodium lauryl sulphate; Described adhesive is carboxymethyl cellulose; Described wetting agent is glycerol; Described antiseptic is sorbitol.

9. the folic acid toothpaste according to any one of claim 1-3, is characterized in that,

10. the folic acid toothpaste according to claim 4 or 5, is characterized in that,