CN103520054A - Application of uncaria extract in preparation of oral care product - Google Patents
Application of uncaria extract in preparation of oral care product Download PDFInfo
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- CN103520054A CN103520054A CN201310489654.0A CN201310489654A CN103520054A CN 103520054 A CN103520054 A CN 103520054A CN 201310489654 A CN201310489654 A CN 201310489654A CN 103520054 A CN103520054 A CN 103520054A
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- ramulus uncariae
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Abstract
The invention discloses an application of uncaria extract in preparation of an oral care product, namely adding uncaria extract into the oral care product as an active ingredient used for relieving gum bleeding in the preparation of the oral care product. Compared with the prior art, the application of uncaria extract in preparation of the oral care product can effectively reduce gum bleeding symptoms and has the advantages of resistance to gingivitis and periodontitis, protection on oral mucosa, low irritation, safety in application, available raw materials and low manufacturing cost.
Description
Technical field
The present invention relates to oral care implement technical field, the application of especially a kind of Ramulus Uncariae Cum Uncis extract in preparing oral care product.
Background technology
The conventional oral care product of people is mainly toothpaste, collutory, dentifrice etc., and its basic function is exactly cleaning teeth, and protection gingiva, safeguards the hygiene and health in oral cavity.Raising along with people's living standard, the health care consciousness of consumer constantly strengthens, oral care product has also been proposed to more requirement, people have also increased some except having this basic function that cleans the teeth to the requirement of toothpaste and collutory can assist the effect of prevention oral disease, therefore, toothpaste in the market and collutory almost all add the functional component for the various oral diseases of control, therefore the product that oral care product both domestic and external has various functional types has become the market mainstream, is wherein to add western medicine composition to realize mostly.
But along with economic development, be accompanied by day by day manifesting of the problems such as environmental pollution, ecological disturbance, consumer more and more pays close attention to the safety of product, thereby more and more advocates natural and safe product.Interpolation can effectively prevent and treat the oral care product of various oral disease Chinese herbal medicine, little with its toxic and side effects, features such as green, environmental protection, safety height and be doubly subject to people's favor, and on market, the consumption demand of this series products is in continuous growth.In addition, along with the development of modernization of Chinese medicine technology, the method for Chinese medicine study of active components utilization has also been obtained to fine development, this assists prevention oral disease that good technical support is provided for oral care product utilizes active ingredient of Chinese herbs.
Gingival hemorrhage is one of department of stomatology common sympton, refers to that gingiva is idiopathic or due to bleeding on a small quantity that minimal irritation causes.The lighter only shows as sucking, brush teeth, while chewing harder food in saliva with the blood streak, severe one is hemorrhage more even hematostaxis when gingiva is subject to minimal irritation.Generally speaking, the chronic inflammatory disease of gingiva is the common cause of gingival hemorrhage, therefore gingival hemorrhage is more common in periodontitis and gingivitis patients.According to interrelated data, show, due to bad dietary habit and think little of oral hygiene, at different times, there is gingival hemorrhage in various degree in increasing crowd, for this reason, be necessary to comply with the needs of market development, the Chinese herbal medicine extract safely and effectively of usining is developed a kind of oral care product of special alleviation gingival hemorrhage as active component.
Ramulus Uncariae Cum Uncis is the dry stem and branch with belt hook for Maguireothamnus speciosus Ramulus Uncariae Cum Uncis Uncaria rhynchophylla (Miq.) Miq.ex Havil, Ramulus Uncariae macrophyllae Uncaria macrophylla Wall, Ramulus Uncariae Cum Uncis Uncaria hirsute Havil, Uncaria sinensis (Oliv.) Havil. Uncaria sinensis (Oliv.) Havil. or stockless fruit Ramulus Uncariae Cum Uncis Uncaria sessilifructus Roxb.Nature and flavor sweetness and bitterness, be slightly cold.Major function heat clearing away suppressing the hyperactive liver; Relieving spasm by subduing liver-wind.Be mainly used in treating infantile convulsion; Night cry; Intenseness of heat wind symptom; Eclamposia; Dizziness due to hyperactivity of liver-YANG; Liver-fire distending pain in the head.
From consulting patent of invention in recent years, also have to relate to and use the patent that Ramulus Uncariae Cum Uncis is applied aspect oral cavity, if " a kind of Chinese medicine for the treatment of recurrent oral ulceration " application number is 201010101079.9, this invention is made by the raw material of multi-flavor parts by weight: Rhizoma Dioscoreae Bulbiferae 3-5 part, Caulis Bambusae In Taenia 5-7 part, Semen Armeniacae Amarum 3-5 part, Radix Stemonae 1-3 part, Semen Lepidii (Semen Descurainiae) 4-6 part, Ramulus Uncariae Cum Uncis 6-8 part, Herba Apocyni veneti 4-6 part, Rhizoma Acori Graminei 1-3 part, Fructus Trichosanthis 1-3 part, Cortex Albiziae 2-4 part, Radix Arnebiae (Radix Lithospermi) 6-8 part, Radix Platycodonis 4-6 part, Os Draconis 2-4 part, Semen Ziziphi Spinosae 2-4 part, Rhizoma Gastrodiae 4-6 part, Fructus Tribuli 1-3 part, Borneolum Syntheticum 4-6 part.And for example, " flavonoid composition that is used for the treatment of oral disease ", patent is CN200580043644.8, this invention provides a kind of two class special compounds that comprise---and without the new compositions that replaces the mixture of B lopps flavone and flavane, it is for disease and the disease of preventing and treatment is relevant to oral cavity, gingiva and tooth.This compositions can suppress the activity of cyclooxygenase (COX) and lipoxygenase (LOX) simultaneously, and can reduce the synthetic of cytokine in the periodontal cell of normal, aging and damage and tissue in mRNA level; It is a kind of for preventing and treat the disease of oral cavity, tooth and gingiva and the method for disease that this invention also provides, for prevent and treat the disease of oral cavity, tooth and gingiva and the method for disease comprise to have these needs main body drug treatment effective dose comprise syntheticly and/or from one or more plants, preferably in the plant of Radix Scutellariae, Semen Oroxyli, Acacia farnesiana Willd. or wild gambier, the separated mixture without replacement B lopps flavone and flavane and materia medica and/or cosmetology can be accepted the compositions of carrier; For another example, " for prosopalgic Ramulus Uncariae Cum Uncis stone acid soup " patent No. is CN201110008218.8, this invention adopt multi-flavor medicine as Ramulus Uncariae Cum Uncis, Concha Haliotidis, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Herba Taxilli, Semen Ziziphi Spinosae, Radix Scutellariae, Fructus Gardeniae, Poria, Rhizoma Gastrodiae, Fructus Tribuli, Radix Polygalae, Cortex Albiziae, the Rhizoma Anemarrhenae, Rhizoma Chuanxiong, Scorpio be that raw material is made with the prosopalgic sour soup for the treatment of, this has strengthening vital QI to eliminate pathogenic factors, the cold expelling heat that disappears, blood circulation promoting and blood stasis dispelling, dispelling wind and removing obstruction in the collateral, the function of the kidney invigorating pain relieving.These disclosed documents are Ramulus Uncariae Cum Uncis to be applied to the aspects such as treatment and preventing canker sore, not for preventing and treating the application of gingival hemorrhage aspect, and the more not application in oral care implement.
Summary of the invention
The problem that the present invention solves is to provide the application scheme of Ramulus Uncariae Cum Uncis extract in preparing oral care product, and this oral cavity nursing health products has the effect of obvious control gingival hemorrhage.
The application scheme of Ramulus Uncariae Cum Uncis extract of the present invention in preparing oral care product is exactly Ramulus Uncariae Cum Uncis extract to be usingd to the form of single medicinal material in preparing the technique of oral care implement to join in oral care product as the active component of anastalsis.
In technique scheme, scheme can also be more specifically: described Chinese medicine Ramulus Uncariae Cum Uncis extract in preparing toothpaste technique as the raw material of anastalsis.
Further: the percentage by weight of described Chinese medicine Ramulus Uncariae Cum Uncis extract in total mastic of toothpaste is 1.0 ~ 10.0%, and described Chinese medicine Ramulus Uncariae Cum Uncis extract is Ramulus Uncariae Cum Uncis ethanol extraction.
Further: described Chinese medicine Ramulus Uncariae Cum Uncis extract in preparing collutory technique as the raw material of anastalsis.
Further: the percentage by weight of described Chinese medicine Ramulus Uncariae Cum Uncis extract in collutory raw material is 1.0 ~ 10.0%, and described Chinese medicine Ramulus Uncariae Cum Uncis extract is Ramulus Uncariae Cum Uncis ethanol extraction.
Further: described Chinese medicine Ramulus Uncariae Cum Uncis extract in preparing dentifrice technique as the raw material of anastalsis.
Further: the percentage by weight of described Chinese medicine Ramulus Uncariae Cum Uncis extract in dentifrice raw material is 1.0 ~ 10.0%, and described Chinese medicine Ramulus Uncariae Cum Uncis extract is Ramulus Uncariae Cum Uncis ethanol extraction.
Further: described Chinese medicine Ramulus Uncariae Cum Uncis extract in preparing throat lozenge technique as the raw material of anastalsis.
Further: the percentage by weight of described Chinese medicine Ramulus Uncariae Cum Uncis extract in throat lozenge raw material is 1.0 ~ 10.0%, and described Chinese medicine Ramulus Uncariae Cum Uncis extract is Ramulus Uncariae Cum Uncis ethanol extraction.
Further: described Chinese medicine Ramulus Uncariae Cum Uncis extract in preparing chewing gum technique as the raw material of anastalsis.
Further: the percentage by weight of described Chinese medicine Ramulus Uncariae Cum Uncis extract in chewing-gum material is 1.0 ~ 10.0%, and described Chinese medicine Ramulus Uncariae Cum Uncis extract is Ramulus Uncariae Cum Uncis ethanol extraction.
The said Ramulus Uncariae Cum Uncis of the present invention is the dry root of rosaceous plant Ramulus Uncariae Cum Uncis Sanguisorba officinalis L. or Ramulus Uncariae Cum Uncis Sanguisorba officinalis L. var. longifolia (Bert.) the Y ü et Li that comes into leaves.Major function cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore.
The mentioned Ramulus Uncariae Cum Uncis of the present invention is the dry root of rosaceous plant Ramulus Uncariae Cum Uncis or the Ramulus Uncariae Cum Uncis that comes into leaves.
In the present invention, be to use with the form of Ramulus Uncariae Cum Uncis extract, Ramulus Uncariae Cum Uncis extract extracting method is that Ramulus Uncariae Cum Uncis is broken into granularity, with the alcohol heating reflux of 10 times of amounts, extracts 3 hours, extracts 3 times, then extracting solution concentrating under reduced pressure is become to extractum or is dried to powdery.The extracting method of Ramulus Uncariae Cum Uncis is not limited to said method, also can adopt the additive methods such as supercritical extraction, ultrasonic extraction to extract; Also can use existing commercially available Chinese medicine Ramulus Uncariae Cum Uncis extract.
It is example that the content of the Ramulus Uncariae Cum Uncis extract described in the present invention all be take the pure extract powder that active component is 100%, but is not limited to pure extract powder, can be also other forms such as extracting solution or extractum; When being applied to toothpaste with other forms as extracting solution, the addition in formula should be converted to the amount of disclosed pure form of extract in the present invention.
The present invention confirms through pharmacological evaluation, and the oral care product that contains Ramulus Uncariae Cum Uncis extract has the effect of significant alleviation gingival hemorrhage, antiinflammatory.
The present invention carries out the anastalsis experiment of laboratory animal white rabbit liver local woanded surface bleeding due to trauma to the toothpaste containing Ramulus Uncariae Cum Uncis extract, make positive control and blank simultaneously and observe.Experimental result shows, this Ramulus Uncariae Cum Uncis extract toothpaste and positive control medicine YUNNAN BAIYAO, with the comparison of blank group, all have obvious anastalsis to rabbit liver local woanded surface bleeding due to trauma, there were significant differences statistically, shows that this Ramulus Uncariae Cum Uncis extract toothpaste has significant anastalsis.
The specific embodiment
Below in conjunction with embodiment, the present invention will be further described.In following each embodiment, related percentage ratio except as otherwise noted, is all to calculate by weight percentage.
embodiment 1-5: the application of Ramulus Uncariae Cum Uncis extract in toothpaste.
the toothpaste constitutive material of embodiment 1-5 and weight percent content are as following table:
the toothpaste preparation technology of embodiment 2 adopts the one-step method preparation of conventional medicine toothpaste:
the liquid materials such as the pure water that input measures in temporary cylinder, sorbitol, Ramulus Uncariae Cum Uncis extract; In pre-dispersed still, drop into the calcite in powder, saccharin sodium, carboxycellulose sodium, sodium lauryl sulphate, the nipalgin that measure and mix the powders such as ester sodium, carry out pre-dispersed, mixing; Open cream still vacuum pump processed and suck above-mentioned liquid material; Then open scraper, enter above-mentioned powder, drive agitator and colloid mill, after 50 minutes, drop into essence, close successively colloid mill, agitator, scraper after 10 minutes, vacuum breaker, stops vacuum pump, after sampling detection is qualified, makes.
the preparation method of above-mentioned other embodiment is with reference to embodiment 2.
embodiment 6-10: the application of Ramulus Uncariae Cum Uncis extract in collutory.
the collutory constitutive material of embodiment 6-10 and weight percent content are as following table:
The preparation method of above-described embodiment 7 collutorys is:
First Ramulus Uncariae Cum Uncis extract, nipalgin mixed ester sodium are added stirring and dissolving in edible ethanol to be placed in temporary pot, sorbitol, deionization, castor oil hydrogenated-40 are added in agitated kettle and stirred 10 minutes, alcoholic solution in temporary pot is added in agitated kettle and stirred 10 minutes, finally add essence to stir 5 minutes, stop stirring, after sampling detection is qualified, make.
The preparation method of the collutory of above-mentioned other embodiment is with reference to embodiment 7.
Embodiment 11-15: the application of Ramulus Uncariae Cum Uncis extract in dentifrice.
The dentifrice constitutive material of embodiment 11-15 and weight percent content are as following table:
In above-described embodiment 12; after natural whiting, sodium carboxymethyl cellulose, sodium lauryl sulphate, saccharin sodium are weighed up by formula consumption, add in mixing agitator and stir after 20 minutes and add Ramulus Uncariae Cum Uncis extract to stir 10 minutes; finally add essence, sorbitol to stir after 20 minutes and shut down, after sampling detection is qualified, make.
In above-described embodiment 13; after calcium phosphate dibasic dihydrate, silicon dioxide, sodium carboxymethyl cellulose, saccharin sodium, sodium lauryl sulphate, nipalgin mixed ester sodium are weighed up by formula consumption, add in mixing agitator and stir after 20 minutes; add Ramulus Uncariae Cum Uncis extract to stir 10 minutes; finally add essence, sorbitol to stir after 20 minutes and shut down, after sampling detection is qualified, make.
Embodiment 11 is with reference to executing example 12, and other embodiment, with reference to executing example 13.
Embodiment 16-20: the application of Ramulus Uncariae Cum Uncis extract in throat lozenge.
The throat lozenge constitutive material of embodiment 16-20 and weight percent content are as following table:
The preparation technology of above-described embodiment adopts existing throat lozenge production technology.
Embodiment 21-25: the application of Ramulus Uncariae Cum Uncis extract in chewing gum.
The chewing gum constitutive material of embodiment 21-25 and weight percent content are as following table:
The preparation technology of above-described embodiment adopts existing chewing gum production technology.
clinical trial part:
the anastalsis pharmacological experiment of Ramulus Uncariae Cum Uncis extract toothpaste;
Get 55 of healthy white rabbit, body weight 2.0～2.5kg, male and female dual-purpose.With 3% pentobarbital sodium 30mg/kg auricular vein, slowly inject, after family's rabbit anesthesia, lie on the back and be fixed on operating-table, abdominal part median incision is about 6～8cm, and exposure fixedly liver, cut liver organization with operating scissors at leftlobe of liver and be about 1cm, wide about 1cm, high about 1cm, it is hemorrhage that wound surface is injection sample.Wipe after the blood of ejection, at the local spreading of wound surface matter sample 1g to be tried, gauze is topped immediately, with 200g counterweight compressing 1min, after 1min, remove counterweight, observe haemostatic effect, take not hemorrhage is hemostasis, as still hemorrhage, add spreading and after trying matter sample, continue pressurization, every 30s, observe once, record bleeding stopping period, as still hemorrhage in surpassed 3min, be designated as and fail to stop blooding, bleeding stopping period is designated as > 3min.After each sample test, with 37 ℃ of normal saline, wash away residual tested material, make wound surface again hemorrhage, then test next tested material sample.Every rabbit carries out liver local woanded surface damage hemostasis test experiments four times, and each tested material sample is pressed the drug of topical application of Latin square program, to reduce the impact of liver local woanded surface damage otch difference and medication order.Blank group, the blank matrix group of toothpaste, positive drug YUNNAN BAIYAO group, Ramulus Uncariae Cum Uncis toothpaste sample group.Each tested material sample amounts to the hemostasis experiment of carrying out 20 rabbit liver local woanded surface bleeding due to traumies.Haemostatic effect is designated as score value F by scoring method reciprocal (10/T), and 3min fails to stop blooding above, and F is designated as 0 without score value.Record and carry out statistics t check, the results are shown in Table 1:
experimental result shows, Ramulus Uncariae Cum Uncis toothpaste sample group and YUNNAN BAIYAO group all have obvious haemostatic effect to rabbit liver local woanded surface bleeding due to trauma, show that Ramulus Uncariae Cum Uncis toothpaste sample group and YUNNAN BAIYAO group have obvious anastalsis,
conclusion: the sample sets containing Ramulus Uncariae Cum Uncis extract toothpaste all has obvious haemostatic effect to rabbit liver local woanded surface bleeding due to trauma, has obvious anastalsis.
Claims (11)
1. the application of Ramulus Uncariae Cum Uncis extract in preparing oral care product, the form of single medicinal material of in preparing the technique of oral care implement, Ramulus Uncariae Cum Uncis extract being usingd adds in oral care product as the active component of alleviating gingival hemorrhage.
2. the application of Ramulus Uncariae Cum Uncis extract according to claim 1 in preparing oral care product, is characterized in that: described Chinese medicine Ramulus Uncariae Cum Uncis extract in preparing toothpaste technique as the raw material of anastalsis.
3. the application of Ramulus Uncariae Cum Uncis extract according to claim 2 in preparing oral care product, it is characterized in that: the percentage by weight of described Chinese medicine Ramulus Uncariae Cum Uncis extract in total mastic of toothpaste is 1.0-10.0%, and described Chinese medicine Ramulus Uncariae Cum Uncis extract is Ramulus Uncariae Cum Uncis ethanol extraction.
4. the application of Ramulus Uncariae Cum Uncis extract according to claim 1 in preparing oral care product, is characterized in that: described Chinese medicine Ramulus Uncariae Cum Uncis extract in preparing collutory technique as the raw material of anastalsis.
5. the application of Ramulus Uncariae Cum Uncis extract according to claim 4 in preparing oral care product, it is characterized in that: the percentage by weight of described Chinese medicine Ramulus Uncariae Cum Uncis extract in collutory raw material is 1.0-10.0%, and described Chinese medicine Ramulus Uncariae Cum Uncis extract is Ramulus Uncariae Cum Uncis ethanol extraction.
6. the application of Ramulus Uncariae Cum Uncis extract according to claim 1 in preparing oral care product, is characterized in that: described Chinese medicine Ramulus Uncariae Cum Uncis extract in preparing dentifrice technique as the raw material of anastalsis.
7. the application of Ramulus Uncariae Cum Uncis extract according to claim 6 in preparing oral care product, is characterized in that: the percentage by weight of described Chinese medicine Ramulus Uncariae Cum Uncis extract in dentifrice raw material is 1.0-10.0%, and described Chinese medicine Ramulus Uncariae Cum Uncis extract is Ramulus Uncariae Cum Uncis ethanol extraction.
8. the application of Ramulus Uncariae Cum Uncis extract according to claim 1 in preparing oral care product, is characterized in that: described Chinese medicine Ramulus Uncariae Cum Uncis extract in preparing throat lozenge technique as the raw material of anastalsis.
9. the application of Ramulus Uncariae Cum Uncis extract according to claim 8 in preparing oral care product, it is characterized in that: the percentage by weight of described Chinese medicine Ramulus Uncariae Cum Uncis extract in throat lozenge raw material is 1.0-10.0%, and described Chinese medicine Ramulus Uncariae Cum Uncis extract is Ramulus Uncariae Cum Uncis ethanol extraction.
10. the application of Ramulus Uncariae Cum Uncis extract according to claim 1 in preparing oral care product, is characterized in that: described Chinese medicine Ramulus Uncariae Cum Uncis extract in preparing chewing gum technique as the raw material of anastalsis.
11. application of Ramulus Uncariae Cum Uncis extract according to claim 10 in preparing oral care product, it is characterized in that: the percentage by weight of described Chinese medicine Ramulus Uncariae Cum Uncis extract in chewing-gum material is 1.0-10.0%, and described Chinese medicine Ramulus Uncariae Cum Uncis extract is Ramulus Uncariae Cum Uncis ethanol extraction.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105533025A (en) * | 2015-12-16 | 2016-05-04 | 南方医科大学 | Uncaria hirsuta leaf tea and preparation method thereof |
| RU2716501C1 (en) * | 2019-03-11 | 2020-03-12 | Тамара Владимировна Пономаренко | Composition for preventing and treating inflammatory diseases of oral cavity |
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| US20070110683A1 (en) * | 2005-11-16 | 2007-05-17 | Gosmile, Inc. | Oral care formulation |
| CN101083981A (en) * | 2004-10-19 | 2007-12-05 | 尤尼根制药公司 | Flavonoid composition for treating oral diseases |
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| CN101083981A (en) * | 2004-10-19 | 2007-12-05 | 尤尼根制药公司 | Flavonoid composition for treating oral diseases |
| US20070110683A1 (en) * | 2005-11-16 | 2007-05-17 | Gosmile, Inc. | Oral care formulation |
Non-Patent Citations (1)
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| 黄浩炜等: "反佐理论初探", 《中医杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105533025A (en) * | 2015-12-16 | 2016-05-04 | 南方医科大学 | Uncaria hirsuta leaf tea and preparation method thereof |
| RU2716501C1 (en) * | 2019-03-11 | 2020-03-12 | Тамара Владимировна Пономаренко | Composition for preventing and treating inflammatory diseases of oral cavity |
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