CN103520054B - Ramulus Uncariae Cum Uncis extract application in preparing oral care product - Google Patents
Ramulus Uncariae Cum Uncis extract application in preparing oral care product Download PDFInfo
- Publication number
- CN103520054B CN103520054B CN201310489654.0A CN201310489654A CN103520054B CN 103520054 B CN103520054 B CN 103520054B CN 201310489654 A CN201310489654 A CN 201310489654A CN 103520054 B CN103520054 B CN 103520054B
- Authority
- CN
- China
- Prior art keywords
- ramulus uncariae
- cum uncis
- uncariae cum
- oral care
- uncis extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
The application in preparing oral care product of the disclosure Ramulus Uncariae Cum Uncis extract; namely in the technique prepare oral care implement, Ramulus Uncariae Cum Uncis extract is added in oral care product as the active component alleviating gingival hemorrhage; compared with prior art; the present invention can not only effectively reduce gingival hemorrhage symptom; and resist gingivitis, periodontitis; protection oral mucosa, zest is low, use safety, raw material sources extensively, the advantage of low cost of manufacture.
Description
Technical field
The present invention relates to oral care implement technical field, the application in preparing oral care product of especially a kind of Ramulus Uncariae Cum Uncis extract.
Background technology
The oral care product that people commonly use is mainly toothpaste, collutory, dentifrice etc., and its basic function cleans tooth exactly, protects gingiva, safeguards the hygiene and health in oral cavity.Raising along with people's living standard, the health care consciousness of consumer constantly strengthens, oral care product be it is also proposed more requirement, the requirement of toothpaste and collutory be also add some effects that can assist prevention oral disease by people except having this basic function that cleans the teeth, therefore, toothpaste and collutory in the market almost all add for the functional component preventing and treating various oral diseases, therefore oral care product both domestic and external has the product of various functional type has become the market mainstream, is wherein add western medicine composition to realize mostly.
But being as the development of economy, along with day by day manifesting of the problem such as environmental pollution, ecological disturbance, the safety of product is increasingly paid close attention to by consumer, thus increasingly advocating natural and safe product.Interpolation can effectively prevent and treat the oral care product of various oral disease Chinese herbal medicine, little with its toxic and side effects, green, environmental protection, safety high and be subject to the favor of people again, on market, the consumption demand of this series products is in continuous growth.It addition, along with the development of modernization of Chinese medicine technology, the method that Chinese medicine study of active components is utilized have also been obtained fine development, this utilizes active ingredient of Chinese herbs to assist prevention oral disease to provide good technical support for oral care product.
Gingival hemorrhage is one of department of stomatology common sympton, refers to that gingiva is idiopathic or owing to what minimal irritation caused bleeds on a small quantity.The lighter show as only sucking, brush teeth, chew during harder food in saliva with the blood streak, severe one is when gingiva is subject to minimal irritation and hemorrhage more even hematostaxis.It is said that in general, the chronic inflammatory disease of gingiva is the common cause of gingival hemorrhage, therefore gingival hemorrhage is more common in periodontitis and gingivitis patients.Show according to relevant information, due to bad dietary habit and think little of oral hygiene, gingival hemorrhage in various degree is there is in increasing crowd at different times, for this, it is necessary to comply with the needs of market development, develops the oral care product of a kind of special alleviation gingival hemorrhage using safely and effectively Chinese herbal medicine extract as active component.
Ramulus Uncariae Cum Uncis is Maguireothamnus speciosus Ramulus Uncariae Cum Uncis Uncariarhynchophylla (Miq.) Miq.exHavil, Ramulus Uncariae macrophyllae UncariamacrophyllaWall, Ramulus Uncariae Cum Uncis UncariahirsuteHavil, Uncaria sinensis (Oliv.) Havil. Uncariasinensis (Oliv.) Havil. or stockless fruit Ramulus Uncariae Cum Uncis UncariasessilifructusRoxb dry stem and branch with belt hook.Nature and flavor sweetness and bitterness, it is slightly cold.Major function heat clearing away suppressing the hyperactive liver；Relieving spasm by subduing liver-wind.It is mainly used in treatment infantile convulsion；Night cry；Intenseness of heat wind symptom；Eclamposia；Dizziness due to hyperactivity of liver-YANG；Liver-fire distending pain in the head.
From the patent of invention consulted in recent years, also the patent using Ramulus Uncariae Cum Uncis to apply in oral cavity is related to, if " a kind of Chinese medicine treating recurrent oral ulceration " application number is 201010101079.9, this invention is made up of the raw material of multi-flavor parts by weight: Rhizoma Dioscoreae Bulbiferae 3-5 part, Caulis Bambusae In Taenia 5-7 part, Semen Armeniacae Amarum 3-5 part, Radix Stemonae 1-3 part, Semen Lepidii (Semen Descurainiae) 4-6 part, Ramulus Uncariae Cum Uncis 6-8 part, Herba Apocyni veneti 4-6 part, Rhizoma Acori Graminei 1-3 part, Fructus Trichosanthis 1-3 part, Cortex Albiziae 2-4 part, Radix Arnebiae (Radix Lithospermi) 6-8 part, Radix Platycodonis 4-6 part, Os Draconis 2-4 part, Semen Ziziphi Spinosae 2-4 part, Rhizoma Gastrodiae 4-6 part, Fructus Tribuli 1-3 part, Borneolum Syntheticum 4-6 part.And for example, " for treating the flavonoid composition of oral disease ", patent is CN200580043644.8, this invention provides a kind of and comprises the two class special compounds new compositions without the mixture replacing B Ring flavonoid and flavane, and it is for preventing and treating the disease relevant to oral cavity, gingiva and tooth and disease.This compositions can suppress cyclooxygenase (COX) and the activity of lipoxygenase (LOX) simultaneously, and can reduce the synthesis of cytokine in periodontal cell that is normal, aging and that damage and tissue in mRNA level in-site；This invention additionally provides a kind of method of disease and disease for preventing and treat oral cavity, tooth and gingiva, the method of disease and disease for preventing and treat oral cavity, tooth and gingiva includes comprising synthesis and/or from one or more plants to the main body drug treatment effective dose having these needs, it is preferable that the compositions without the mixture and materia medica and/or cosmetology acceptable carriers that replace B Ring flavonoid and flavane separated in the plant of Radix Scutellariae, Semen Oroxyli, Acacia farnesiana Willd. or wild gambier；For another example, " for prosopalgic Ramulus Uncariae Cum Uncis stone acid soup " patent No. is CN201110008218.8, this invention adopts multi-flavor medicine such as Ramulus Uncariae Cum Uncis, Concha Haliotidis, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Herba Taxilli, Semen Ziziphi Spinosae, Radix Scutellariae, Fructus Gardeniae, Poria, Rhizoma Gastrodiae, Fructus Tribuli, Radix Polygalae, Cortex Albiziae, the Rhizoma Anemarrhenae, Rhizoma Chuanxiong, Scorpio to be that raw material is made with treatment prosopalgic acid soup, this has strengthening vital QI to eliminate pathogenic factors, cold expelling disappears heat, blood circulation promoting and blood stasis dispelling, dispelling wind and removing obstruction in the collateral, the function of the kidney invigorating pain relieving.Document disclosed in these is to be applied to Ramulus Uncariae Cum Uncis treat and prevent the aspects such as oral ulcer, has not been used to the application of preventing and treating gingival hemorrhage aspect, the more not application in oral care implement.
Summary of the invention
The problem that this invention address that is to provide Ramulus Uncariae Cum Uncis extract application scheme in preparing oral care product, and this oral cavity nursing health products has the effect significantly preventing and treating gingival hemorrhage.
The Ramulus Uncariae Cum Uncis extract of present invention application scheme in preparing oral care product is exactly joined in oral care product using the form of single medicinal material as the active component of anastalsis by Ramulus Uncariae Cum Uncis extract in the technique prepare oral care implement.
In technique scheme, more specifically scheme it may also is that described Chinese medicine Ramulus Uncariae Cum Uncis extract in preparing toothpaste technique as the raw material of anastalsis.
Further: described Chinese medicine Ramulus Uncariae Cum Uncis extract percentage by weight in total mastic of toothpaste is 1.0 ~ 10.0%, and described Chinese medicine Ramulus Uncariae Cum Uncis extract is Ramulus Uncariae Cum Uncis ethanol extraction.
Further: described Chinese medicine Ramulus Uncariae Cum Uncis extract in preparing collutory technique as the raw material of anastalsis.
Further: described Chinese medicine Ramulus Uncariae Cum Uncis extract percentage by weight in collutory raw material is 1.0 ~ 10.0%, and described Chinese medicine Ramulus Uncariae Cum Uncis extract is Ramulus Uncariae Cum Uncis ethanol extraction.
Further: described Chinese medicine Ramulus Uncariae Cum Uncis extract in preparing dentifrice technique as the raw material of anastalsis.
Further: described Chinese medicine Ramulus Uncariae Cum Uncis extract percentage by weight in dentifrice raw material is 1.0 ~ 10.0%, and described Chinese medicine Ramulus Uncariae Cum Uncis extract is Ramulus Uncariae Cum Uncis ethanol extraction.
Further: described Chinese medicine Ramulus Uncariae Cum Uncis extract in preparing throat lozenge technique as the raw material of anastalsis.
Further: described Chinese medicine Ramulus Uncariae Cum Uncis extract percentage by weight in throat lozenge raw material is 1.0 ~ 10.0%, and described Chinese medicine Ramulus Uncariae Cum Uncis extract is Ramulus Uncariae Cum Uncis ethanol extraction.
Further: described Chinese medicine Ramulus Uncariae Cum Uncis extract in preparing chewing gum technique as the raw material of anastalsis.
Further: described Chinese medicine Ramulus Uncariae Cum Uncis extract percentage by weight in chewing-gum material is 1.0 ~ 10.0%, and described Chinese medicine Ramulus Uncariae Cum Uncis extract is Ramulus Uncariae Cum Uncis ethanol extraction.
Ramulus Uncariae Cum Uncis described in the present invention is rosaceous plant Ramulus Uncariae Cum Uncis SanguisorbaofficinalisL. or the dry root of Ramulus Uncariae Cum Uncis SanguisorbaofficinalisL.var.longifolia (Bert.) the Y ü etLi that comes into leaves.Major function cooling blood for hemostasis, heat-clearing and toxic substances removing, sore of subsiding a swelling.
Ramulus Uncariae Cum Uncis mentioned by the present invention is rosaceous plant Ramulus Uncariae Cum Uncis or the dry root of the Ramulus Uncariae Cum Uncis that comes into leaves.
Being use with the form of Ramulus Uncariae Cum Uncis extract in the present invention, Ramulus Uncariae Cum Uncis extract extracting method is that Ramulus Uncariae Cum Uncis is broken into granularity, extracts 3 hours with the alcohol heating reflux of 10 times amount, extracts 3 times, then extracting solution concentrating under reduced pressure become extractum or be dried to powdery.The extracting method of Ramulus Uncariae Cum Uncis is not limited to said method, and the additive method such as supercritical extraction, ultrasonic extraction also can be adopted to extract；Existing commercially available Chinese medicine Ramulus Uncariae Cum Uncis extract can also be used.
The pure extract powder that the content of heretofore described Ramulus Uncariae Cum Uncis extract is all 100% for active component, but it is not limited to pure extract powder, it is also possible to it is other form such as extracting solution or extractum；In time being applied to toothpaste such as extracting solution otherwise, the addition in formula should be converted to the amount of the pure form of extract that disclosed in this invention.
The present invention confirms through pharmacological evaluation, and the oral care product containing Ramulus Uncariae Cum Uncis extract has the effect alleviating gingival hemorrhage, antiinflammatory significantly.
Toothpaste containing Ramulus Uncariae Cum Uncis extract is carried out the anastalsis experiment of laboratory animal white rabbit liver local woanded surface bleeding due to trauma by the present invention, makes positive control simultaneously and observes with blank.Test result indicate that, this Ramulus Uncariae Cum Uncis extract toothpaste and positive control medicine YUNNAN BAIYAO, compare with blank group, all rabbit liver local woanded surface bleeding due to trauma is had obvious anastalsis, there were significant differences statistically, it was shown that this Ramulus Uncariae Cum Uncis extract toothpaste has significant anastalsis.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.In following examples, involved percentage ratio except as otherwise noted, is all calculate by weight percentage.
Embodiment 1-5: Ramulus Uncariae Cum Uncis extract application in toothpaste.
The toothpaste constitutive material of embodiment 1-5 and weight percent content such as following table:
The toothpaste making process of embodiment 2 adopts the one-step method of conventional medicine toothpaste to prepare:
Temporary cylinder puts into measure pure water, sorbitol, the liquid material such as Ramulus Uncariae Cum Uncis extract；Pre-dispersed still puts into measure calcite in powder, saccharin sodium, carboxycellulose sodium, sodium lauryl sulphate, the powder such as the mixed ester sodium of nipalgin, carry out pre-dispersed, mixing；Open cream still vacuum pump processed and suck above-mentioned liquid material；Then open scraper, enter above-mentioned powder, drive agitator and colloid mill, put into essence after 50 minutes, after 10 minutes, close colloid mill, agitator, scraper, vacuum breaker successively, stop vacuum pump, make after sampling detection is qualified.
The preparation method of above-mentioned other embodiments is with reference to embodiment 2.
Embodiment 6-10: Ramulus Uncariae Cum Uncis extract application in collutory.
The collutory constitutive material of embodiment 6-10 and weight percent content such as following table:
The preparation method of above-described embodiment 7 collutory is:
First Ramulus Uncariae Cum Uncis extract, nipalgin mixed ester sodium are added stirring and dissolving in edible ethanol and is placed in temporary pot, sorbitol, deionization, castor oil hydrogenated-40 are added stirring 10 minutes in agitated kettle, alcoholic solution in temporary pot is added stirring 10 minutes in agitated kettle, it is eventually adding essence to stir 5 minutes, stop stirring, make after sampling detection is qualified.
The preparation method of the collutory of above-mentioned other embodiments is with reference to embodiment 7.
Embodiment 11-15: Ramulus Uncariae Cum Uncis extract application in dentifrice.
The dentifrice constitutive material of embodiment 11-15 and weight percent content such as following table:
In above-described embodiment 12; add stirring in mixing agitator after natural whiting, sodium carboxymethyl cellulose, sodium lauryl sulphate, saccharin sodium being weighed up by formula consumption and after 20 minutes, add Ramulus Uncariae Cum Uncis extract stirring 10 minutes; be eventually adding essence, sorbitol is shut down after stirring 20 minutes, makes after sampling detection is qualified.
In above-described embodiment 13; add after mixing agitator stirs 20 minutes after calcium phosphate dibasic dihydrate, silicon dioxide, sodium carboxymethyl cellulose, saccharin sodium, sodium lauryl sulphate, nipalgin mixed ester sodium are weighed up by formula consumption; add Ramulus Uncariae Cum Uncis extract to stir 10 minutes; be eventually adding essence, sorbitol is shut down after stirring 20 minutes, makes after sampling detection is qualified.
Embodiment 11 is with reference to executing example 12, and other embodiments, with reference to executing example 13.
Embodiment 16-20: Ramulus Uncariae Cum Uncis extract application in throat lozenge.
The throat lozenge constitutive material of embodiment 16-20 and weight percent content such as following table:
The preparation technology of above-described embodiment adopts existing throat lozenge production technology.
Embodiment 21-25: Ramulus Uncariae Cum Uncis extract application in chewing gum.
The chewing gum constitutive material of embodiment 21-25 and weight percent content such as following table:
The preparation technology of above-described embodiment adopts existing chewing gum production technology.
Clinical trial part:
The anastalsis pharmacological experiment of Ramulus Uncariae Cum Uncis extract toothpaste；
Take healthy white rabbit 55, body weight 2.0～2.5kg, male and female dual-purpose.It is slowly injected into 3% pentobarbital sodium 30mg/kg auricular vein, after family's rabbit anesthesia, lies on the back and be fixed on operating-table, abdominal part median incision is about 6～8cm, exposes and fixing liver, cuts liver organization with operating scissors at leftlobe of liver and be about 1cm, width is 1cm about, high about 1cm, and wound surface is hemorrhage in injection sample.After wiping the blood of ejection, treating examination matter sample 1g at wound surface local spreading immediately, gauze is covered with, remove counterweight after oppressing 1min, 1min with 200g counterweight, observe haemostatic effect, with not hemorrhage for hemostasis, as still hemorrhage, then add spreading and continue pressurization after examination matter sample, observe once every 30s, record bleeding stopping period, as still hemorrhage more than 3min, being then designated as and fail to stop blooding, bleeding stopping period is designated as > 3min.After each sample test, wash away residual tested material with 37 DEG C of normal saline, make wound surface again hemorrhage, next tested material sample of re-test.Every rabbit carries out four liver local woanded surface damage hemostasis test experiments, and the Latin square program drug of topical application pressed by each tested material sample, to reduce liver local woanded surface damage otch difference and the impact of medication order.Blank group, toothpaste bare substrate group, positive drug YUNNAN BAIYAO group, Ramulus Uncariae Cum Uncis toothpaste sample group.Each tested material sample amounts to the hemostasis experiment carrying out 20 rabbit liver local woanded surface bleeding due to traumies.Haemostatic effect is designated as score value F, more than 3min by scoring method (10/T) reciprocal and fails to stop blooding, and F is designated as 0 without score value.Recording and carry out statistics t inspection, result is in Table 1:
Test result indicate that, rabbit liver local woanded surface bleeding due to trauma is all had obvious haemostatic effect by Ramulus Uncariae Cum Uncis toothpaste sample group and YUNNAN BAIYAO group, it was shown that Ramulus Uncariae Cum Uncis toothpaste sample group and YUNNAN BAIYAO group have obvious anastalsis,
Conclusion: rabbit liver local woanded surface bleeding due to trauma is all had obvious haemostatic effect by the sample sets containing Ramulus Uncariae Cum Uncis extract toothpaste, has obvious anastalsis.
Claims (11)
1. Ramulus Uncariae Cum Uncis extract application in preparing oral care product, namely adds Ramulus Uncariae Cum Uncis extract in oral care product as the active component alleviating gingival hemorrhage using the form of single medicinal material in the technique prepare oral care product；Described Ramulus Uncariae Cum Uncis extract extracting method is that Ramulus Uncariae Cum Uncis is broken into granule, extracts 3 hours with the alcohol heating reflux of 10 times amount, extracts 3 times, then extracting solution concentrating under reduced pressure become extractum or be dried to powdery.
2. the Ramulus Uncariae Cum Uncis extract according to claim 1 application in preparing oral care product, it is characterised in that: described Chinese medicine Ramulus Uncariae Cum Uncis extract in preparing toothpaste technique as the raw material of anastalsis.
3. the Ramulus Uncariae Cum Uncis extract according to claim 2 application in preparing oral care product, it is characterized in that: described Chinese medicine Ramulus Uncariae Cum Uncis extract percentage by weight in total mastic of toothpaste is 1.0～10.0%, and described Chinese medicine Ramulus Uncariae Cum Uncis extract is Ramulus Uncariae Cum Uncis ethanol extraction.
4. the Ramulus Uncariae Cum Uncis extract according to claim 1 application in preparing oral care product, it is characterised in that: described Chinese medicine Ramulus Uncariae Cum Uncis extract in preparing collutory technique as the raw material of anastalsis.
5. the Ramulus Uncariae Cum Uncis extract according to claim 4 application in preparing oral care product, it is characterised in that: described Chinese medicine Ramulus Uncariae Cum Uncis extract percentage by weight in collutory raw material is 1.0～10.0%, and described Chinese medicine Ramulus Uncariae Cum Uncis extract is Ramulus Uncariae Cum Uncis ethanol extraction.
6. the Ramulus Uncariae Cum Uncis extract according to claim 1 application in preparing oral care product, it is characterised in that: described Chinese medicine Ramulus Uncariae Cum Uncis extract in preparing dentifrice technique as the raw material of anastalsis.
7. the Ramulus Uncariae Cum Uncis extract according to claim 6 application in preparing oral care product, it is characterised in that: described Chinese medicine Ramulus Uncariae Cum Uncis extract percentage by weight in dentifrice raw material is 1.0～10.0%, and described Chinese medicine Ramulus Uncariae Cum Uncis extract is Ramulus Uncariae Cum Uncis ethanol extraction.
8. the Ramulus Uncariae Cum Uncis extract according to claim 1 application in preparing oral care product, it is characterised in that: described Chinese medicine Ramulus Uncariae Cum Uncis extract in preparing throat lozenge technique as the raw material of anastalsis.
9. the Ramulus Uncariae Cum Uncis extract according to claim 8 application in preparing oral care product, it is characterised in that: described Chinese medicine Ramulus Uncariae Cum Uncis extract percentage by weight in throat lozenge raw material is 1.0～10.0%, and described Chinese medicine Ramulus Uncariae Cum Uncis extract is Ramulus Uncariae Cum Uncis ethanol extraction.
10. the Ramulus Uncariae Cum Uncis extract according to claim 1 application in preparing oral care product, it is characterised in that: described Chinese medicine Ramulus Uncariae Cum Uncis extract in preparing chewing gum technique as the raw material of anastalsis.
11. the application that Ramulus Uncariae Cum Uncis extract according to claim 10 is in preparing oral care product, it is characterized in that: described Chinese medicine Ramulus Uncariae Cum Uncis extract percentage by weight in chewing-gum material is 1.0～10.0%, and described Chinese medicine Ramulus Uncariae Cum Uncis extract is Ramulus Uncariae Cum Uncis ethanol extraction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310489654.0A CN103520054B (en) | 2013-10-18 | 2013-10-18 | Ramulus Uncariae Cum Uncis extract application in preparing oral care product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310489654.0A CN103520054B (en) | 2013-10-18 | 2013-10-18 | Ramulus Uncariae Cum Uncis extract application in preparing oral care product |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103520054A CN103520054A (en) | 2014-01-22 |
| CN103520054B true CN103520054B (en) | 2016-07-20 |
Family
ID=49922646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310489654.0A Active CN103520054B (en) | 2013-10-18 | 2013-10-18 | Ramulus Uncariae Cum Uncis extract application in preparing oral care product |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103520054B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105533025A (en) * | 2015-12-16 | 2016-05-04 | 南方医科大学 | Uncaria hirsuta leaf tea and preparation method thereof |
| RU2716501C1 (en) * | 2019-03-11 | 2020-03-12 | Тамара Владимировна Пономаренко | Composition for preventing and treating inflammatory diseases of oral cavity |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070110683A1 (en) * | 2005-11-16 | 2007-05-17 | Gosmile, Inc. | Oral care formulation |
| CN101083981A (en) * | 2004-10-19 | 2007-12-05 | 尤尼根制药公司 | Flavonoid composition for treating oral diseases |
-
2013
- 2013-10-18 CN CN201310489654.0A patent/CN103520054B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101083981A (en) * | 2004-10-19 | 2007-12-05 | 尤尼根制药公司 | Flavonoid composition for treating oral diseases |
| US20070110683A1 (en) * | 2005-11-16 | 2007-05-17 | Gosmile, Inc. | Oral care formulation |
Non-Patent Citations (1)
| Title |
|---|
| 反佐理论初探;黄浩炜等;《中医杂志》;20090131;第50卷(第1期);第89-90页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103520054A (en) | 2014-01-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103520052B (en) | Bletilla striata extract is preparing the application in oral care product | |
| CN103520076B (en) | Compound Chinese medicine extract is preparing the application in oral cavity nursing health products | |
| CN102961318B (en) | Application of compound traditional Chinese medicine extract in preparation of oral care health products | |
| CN103520049B (en) | Compound Chinese medicine extract is preparing the application in oral cavity nursing health products | |
| CN102961295B (en) | Application of caulis sinomenii extract to preparation of oral care products | |
| CN106491454A (en) | Chinese medicinal toothpaste | |
| KR102543158B1 (en) | Composition for preventing or treating inflammatory diseases or pain | |
| CN104958219A (en) | Dendrobium stem toothpaste and production method thereof | |
| KR102119568B1 (en) | A compound for preventing hair loss and promoting hair growth | |
| CN103520054B (en) | Ramulus Uncariae Cum Uncis extract application in preparing oral care product | |
| CN103520012A (en) | Application of baicalin in preparation of oral care product | |
| CN103536483B (en) | Radix Sangusorbae extract is preparing the application in oral care product | |
| CN101524320B (en) | Compound preparation capable of freckle-removing, skin-whitening, moisture preservation and wrinkle-resistance | |
| CN103520010A (en) | Application of tetrahydropalmatine and naringin in preparing oral care products | |
| CN106580779A (en) | Chinese herbal toothpaste with macadimia nut extract as main ingredient and preparation method thereof | |
| CN106511423A (en) | Application of annual fleabane herb extract in preparation of mouth care health product | |
| CN103536482B (en) | Compound Chinese medicine extract is as sole active agent application in preparation oral cavity product | |
| CN106420512A (en) | Application of compound traditional Chinese medicine extract in preparing oral care healthcare products | |
| CN102961265A (en) | Application of tetrahydropalmatine to preparation of oral care products | |
| CN106511821A (en) | Pharmaceutical composition with effects of clearing heat, nourishing yin, promoting secretion of saliva or body fluid and stopping bleeding and preparation method of pharmaceutical composition | |
| CN106344460A (en) | Special moisturizing and acne-removing face cream for acne-prone skin and preparation method thereof | |
| CN104622708A (en) | Application of geniposide in preparation of oral care health products | |
| CN105616270A (en) | Chinese herbal toothpaste and preparation method thereof | |
| CN105030592A (en) | Qingyan Duzhong toothpaste and making method thereof | |
| CN104510666A (en) | Mouthwash for treating gingival bleeding |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |