CN106491454A - Chinese medicinal toothpaste - Google Patents
Chinese medicinal toothpaste Download PDFInfo
- Publication number
- CN106491454A CN106491454A CN201611162245.XA CN201611162245A CN106491454A CN 106491454 A CN106491454 A CN 106491454A CN 201611162245 A CN201611162245 A CN 201611162245A CN 106491454 A CN106491454 A CN 106491454A
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- China
- Prior art keywords
- toothpaste
- herba clinopodii
- extract
- chinese medicinal
- lotion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The present invention discloses a kind of Chinese medicinal toothpaste, it is related to technical field of toothpaste, include the Herba Clinopodii extract that percentage by weight is 0.10 ~ 10.0% in its lotion of toothpaste total composition, the Herba Clinopodii extract is added in lotion of toothpaste as the sole active agent of anastalsis, compared with prior art, the present invention has obvious anastalsis to gingival hemorrhage.
Description
Technical field
The present invention relates to a kind of toothpaste, especially a kind of Chinese medicinal toothpaste with preventing and treating gingival hemorrhage.
Background technology
Dental care product is indispensable cleaning in people's daily life and health product, and this class product category is numerous
Many, mainly include toothpaste, collutory, dentifrice, chewing gum, oral spray etc., its basic function is exactly to clean tooth, protection tooth
Gum, promote breath freshening, safeguard oral cavity good environment etc..With the improvement of people's living standards, the health care consciousness of consumer is not
Disconnected enhancing, it is also proposed more requirements to oral care product, and requirement of the people to toothpaste and collutory cleans the teeth this except having
Some effects that can aid in preventing oral disease are also add outside one basic function, therefore, toothpaste in the market and are gargled
Liquid almost all adds the functional component for the various oral diseases of preventing and treating, and therefore oral care product both domestic and external has various work(
The product of energy type has become the market mainstream, is wherein to add western medicine composition to realize mostly.
But with economic continuous development, along with increasingly manifesting the problems such as environmental pollution, ecological disturbance, consumer
The safety of product is increasingly paid close attention to, so as to increasingly advocate natural and safe product.Add and can effectively prevent and treat various mouths
The oral care product of chamber disease Chinese herbal medicine, little with its toxic and side effects, green, environmental protection, safe the features such as and again be subject to people
Favor, the consumption demand of this kind of product on market constantly increasing.In addition, with the development of modernization of Chinese medicine technology, centering
The method that medicine study of active components is utilized also has obtained fine development, and this is aided in using active ingredient of Chinese herbs for oral care product
Prevention oral disease provides good technical support.
Gingival hemorrhage is one of common symptom of the department of stomatology, and generally gingival hemorrhage is common in the morning of periodontitis
Phase gingivitiss, gingivitiss have a polytype, but modal, sickness rate highest is chronic simple gingivitis, this tooth
Gingivitis are also called dirty gingivitis, marginal gingivitiss, and usually said gingivitiss are exactly chronic simple gingivitis.Clinically commonly use
Method be scaling remove tooth body on calculus and oral anti-inflammatory agent, alleviate gingivitis.Therefore, prevent gingival hemorrhage in recent years
Clinical oral doctor's focus of attention is increasingly becoming, has also been subject to oral health care product to produce because of wherein huge commercial value
The favor of manufacturer.For this reason, it is necessary to the needs of market development are complied with, using safely and effectively Chinese herbal medicine extract as active component
A kind of oral care product of special preventing and treating gingival hemorrhage is developed, and modern humans is also complied with to the concept of natural green environmental protection and is wanted
Ask.
Content of the invention
Problem to be solved by this invention is to provide a kind of Chinese medicinal toothpaste with anastalsis.
In order to solve above-mentioned technical problem, the technical solution adopted in the present invention is：
Include the Herba Clinopodii extract that percentage by weight is 0.10～10.0%, the Herba Clinopodii in its lotion of toothpaste total composition
Extract is added in lotion of toothpaste as the sole active agent of anastalsis.
More specifically scheme is：The Herba Clinopodii extract is Herba Clinopodii ethanol extraction.
Herba Clinopodii described in the present invention is labiate Fructus Seu Herba Pubescentiss Clinopodium polycephalum (Vaniot)
C. Y. Wu et Hsuan or Herba Clinopodii Polycephali Clinopodium chinense (Benth.) 0. Kuntze dry overground part
Point.Nature and flavor slight bitter, puckery, cool.Return liver warp.Its major function is astringing to arrest bleeding.For metrorrhagia, hematuria, epistaxis, gingival hemorrhage, wound
Hinder bleeding.
Of the invention compared with existing toothpaste, have the advantages that：
Added in lotion of toothpaste is the material of the active composition proposed from the Chinese medicine of natural plants, can not only be effective
Alleviate the uncomfortable situation such as red swelling of gingiva inflammation, pain, while can also meet the function that consumer prevents oral problem.
The present invention confirms that through pharmacological evaluation toothpaste adds Herba Clinopodii extract in preparation process as natural plant active
Composition has obvious anastalsis, and using safety.
Specific embodiment
With reference to embodiment, the present invention will be further described.In following examples, involved percentage ratio unless
It is otherwise noted, is calculated in weight percent.
First, the preparation of anti-inflammatory and antalgic functional component
Extracting method is that Herba Clinopodii medical material is shredded granulating, is extracted 3 hours with the alcohol heating reflux of 4 times of amounts, and every batch of medical material is carried
Take 3 times, 3 extracting solution are merged concentrating under reduced pressure into crude drug then：Extract=1:1 extracting solution.
The extracting method of Herba Clinopodii of the present invention is not limited to said method, can also adopt supercritical extraction, surpass
The additive methods such as sound wave extraction are extracted；Existing commercially available Chinese medicine Herba Clinopodii extract can also be used.
As a example by heretofore described Herba Clinopodii extract, but be not limited to extracting solution can also be pure extract powder or
The other forms such as person's extractum.When as being applied to oral care product such as extract powder otherwise, the addition in formula
Should be converted to disclosed in this invention pure form of extract amount.
2nd, the toothpaste constitutive material and weight percent content such as table 1 in embodiment 1 to 5：
The preparation method of toothpaste in 1～example of embodiment 5：
Lotion of toothpaste can be made using the one-step method cream production technology of conventional medicine toothpaste：In temporary cylinder, input is measured
The liquid materials such as pure water, Sorbitol, Herba Clinopodii extract；Put in pre-dispersed kettle measure calcite in powder, saccharin sodium, carboxyl
The powders such as the mixed ester sodium of sodium cellulosate, sodium lauryl sulphate, nipalgin, carry out pre-dispersed, mixing；Open cream kettle vacuum pump suction processed
Above-mentioned liquid material；Then open scraper, enter above-mentioned powder, drive agitator and colloid mill, after 50 minutes put into essence, after 10 minutes according to
Secondary closing colloid mill, agitator, scraper, vacuum breaker stop vacuum pump, make after sampling detection is qualified.
Clinical trial part：
Using rabbit liver local woanded surface bleeding due to trauma model, with the toothpaste sample of the present invention, the pharmacological evaluation of anastalsis is carried out：
Take healthy white rabbit 40,2.0～2.5kg of body weight, male and female dual-purpose.Slow with 3% pentobarbital sodium 30mg/kg auricular veins
Injection, after family's rabbit anesthesia, lies on the back and is fixed on operating-table, and abdominal part median incision is about 6～8cm, exposes and fixed liver, uses handss
Art is cut and cuts liver organization in leftlobe of liver and be about 1cm, wide about 1cm, high about 1cm, and wound surface is in injection sample bleeding.Wipe the blood of ejection
Afterwards, immediately in wound surface local spreading thing sample 1g to be tried, gauze is covered with, and oppresses 1min with 200g counterweights, removes counterweight after 1min,
Observation haemostatic effect, with not bleeding as hemostasis, such as still bleeding then plus spreading continues pressurization after examination thing sample, is observed every 30s
Once, bleeding stopping period is recorded, such as more than 3min still bleeding, then is designated as failing to stop blooding, bleeding stopping period is designated as ＞ 3min.Each sample
After product test, residual tested material is washed away with 37 DEG C of normal saline, make wound surface bleeding again, the next tested material sample of re-test.Per
Rabbit carries out four liver local woanded surfaces and damages hemostasis test experiments, and the Latin equation drug of topical application pressed by each tested material sample, to subtract
Few liver local woanded surface damages the impact of otch difference and medication order.Each tested material sample is amounted to and carries out 20 rabbit liver offices
The hemostasis experiment of portion's wound surface bleeding due to trauma.Haemostatic effect is by scoring method reciprocal（10/T）Score value F is designated as, more than 3min fails to stop
Blood, F are designated as 0 without score value.Statistics t inspections are recorded and carried out, 2 are the results are shown in Table.
Haemostatic effect of the 2 Chinese herbal toothpaste sample of table to rabbit liver local woanded surface bleeding due to trauma（±S）
Note：Compare with starch group：### P ＜ 0.001, ▲ P ＞ 0.05.
Compare with toothpaste bare substrate group：* * P ＜ 0.001, △ P ＞ 0.05.
Test result indicate that, Herba Clinopodii extract toothpaste sample group and YUNNAN BAIYAO group are damaged to rabbit liver local woanded surface
Bleeding has obvious haemostatic effect, with obvious anastalsis.Show that the group of toothpaste sample containing Herba Clinopodii extract has substantially
Anastalsis.
Claims (2)
1. a kind of Chinese medicinal toothpaste, it is characterised in that：Include in its lotion of toothpaste total composition percentage by weight for 0.10 ~
10.0% Herba Clinopodii extract, the Herba Clinopodii extract are added in lotion of toothpaste as the sole active agent of anastalsis.
2. Chinese medicinal toothpaste according to claim 1, it is characterised in that：The Herba Clinopodii extract is that Herba Clinopodii ethanol is extracted
Thing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611162245.XA CN106491454A (en) | 2016-12-15 | 2016-12-15 | Chinese medicinal toothpaste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611162245.XA CN106491454A (en) | 2016-12-15 | 2016-12-15 | Chinese medicinal toothpaste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106491454A true CN106491454A (en) | 2017-03-15 |
Family
ID=58330254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611162245.XA Withdrawn CN106491454A (en) | 2016-12-15 | 2016-12-15 | Chinese medicinal toothpaste |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106491454A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107951766A (en) * | 2017-12-05 | 2018-04-24 | 安庆乘风制药有限公司 | Chinese herbal toothpaste composition containing Duanxueliu extract |
| CN111632004A (en) * | 2020-07-27 | 2020-09-08 | 浙江爱尚日用品有限公司 | Anti-inflammation antibacterial hemostasis toothpaste |
| CN112245372A (en) * | 2020-10-30 | 2021-01-22 | 广东宇通医药生物科技有限公司 | Traditional Chinese medicine toothpaste formula for stopping bleeding and diminishing inflammation and preparation method thereof |
| CN113081912A (en) * | 2021-03-15 | 2021-07-09 | 合肥立方制药股份有限公司 | Oral care composition and preparation method thereof |
| CN114848561A (en) * | 2022-07-07 | 2022-08-05 | 云南诺特金参口腔护理用品有限公司 | Toothpaste for preventing and treating dental ulcer and preparation method thereof |
| CN115040582A (en) * | 2022-06-23 | 2022-09-13 | 柳州两面针股份有限公司 | Traditional Chinese medicine gingival-protecting oral care product containing radix zanthoxyli extract |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101804092A (en) * | 2010-04-27 | 2010-08-18 | 南京泽朗医药科技有限公司 | Method for preparing Chinse clinopodium herb total saponins |
| CN104940089A (en) * | 2015-07-15 | 2015-09-30 | 韩诚 | Chinese herb mouth wash |
-
2016
- 2016-12-15 CN CN201611162245.XA patent/CN106491454A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101804092A (en) * | 2010-04-27 | 2010-08-18 | 南京泽朗医药科技有限公司 | Method for preparing Chinse clinopodium herb total saponins |
| CN104940089A (en) * | 2015-07-15 | 2015-09-30 | 韩诚 | Chinese herb mouth wash |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107951766A (en) * | 2017-12-05 | 2018-04-24 | 安庆乘风制药有限公司 | Chinese herbal toothpaste composition containing Duanxueliu extract |
| CN111632004A (en) * | 2020-07-27 | 2020-09-08 | 浙江爱尚日用品有限公司 | Anti-inflammation antibacterial hemostasis toothpaste |
| CN112245372A (en) * | 2020-10-30 | 2021-01-22 | 广东宇通医药生物科技有限公司 | Traditional Chinese medicine toothpaste formula for stopping bleeding and diminishing inflammation and preparation method thereof |
| CN113081912A (en) * | 2021-03-15 | 2021-07-09 | 合肥立方制药股份有限公司 | Oral care composition and preparation method thereof |
| CN115040582A (en) * | 2022-06-23 | 2022-09-13 | 柳州两面针股份有限公司 | Traditional Chinese medicine gingival-protecting oral care product containing radix zanthoxyli extract |
| CN115040582B (en) * | 2022-06-23 | 2023-10-20 | 柳州两面针股份有限公司 | Traditional Chinese medicine gingiva protection oral care product containing radix zanthoxyli extract |
| CN114848561A (en) * | 2022-07-07 | 2022-08-05 | 云南诺特金参口腔护理用品有限公司 | Toothpaste for preventing and treating dental ulcer and preparation method thereof |
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| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20170315 |
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| WW01 | Invention patent application withdrawn after publication |