CN103520049B - Compound Chinese medicine extract is preparing the application in oral cavity nursing health products - Google Patents
Compound Chinese medicine extract is preparing the application in oral cavity nursing health products Download PDFInfo
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Abstract
The invention discloses compound Chinese medicine extract and prepare the application in oral cavity nursing health products, relate to oral care techniques field, namely in the technique preparing oral care product, Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, these four kinds of Chinese medicine extract of Herba Centellae extract are added in oral cavity nursing health products as the ancillary drug raw material of anti-inflammation hemostasia effect, these four kinds of Chinese medicine extract not only use safety in the oral care implements such as toothpaste, collutory, dentifrice, throat lozenge, chewing gum, and there is obvious anti-inflammation hemostasia effect.
Description
Technical field
The present invention relates to oral care techniques field, especially a kind of oral cavity nursing health products with anti-inflammation hemostasia.
Background technology
Dental care product is clean and health product indispensable in people's daily life, this series products is of a great variety, comprise toothpaste, dentifrice, collutory, chewing gum, oral spray etc., be mainly used in keeping oral cavity and cleaning of teeth, promotion breath freshening, nurse gingiva, safeguard oral cavity good environment etc.In recent years, the natural drug Chinese herb medicine that particularly China is traditional is applied in dental care product as active component and solves related oral problem, becomes the focus in market.
Gingival hemorrhage is one of common symptom of the department of stomatology, generally gingival hemorrhage is common in the early stage of periodontitis---gingivitis, gingivitis has polytype, but what modal, sickness rate was the highest is chronic simple gingivitis, this gingivitis is also called dirty gingivitis, marginal gingivitis, and usually said gingivitis is exactly chronic simple gingivitis.Method conventional is clinically that calculus on tooth body and oral anti-inflammatory agent are removed in scaling, alleviates gingivitis.Therefore, prevention gingival hemorrhage becomes the focus that clinical oral doctor pays close attention in recent years gradually, is also subject to the favor of oral health care product production firm because of wherein huge commercial value.Therefore, it is imperative for developing a for the hemorrhage oral problem for the treatment of gingival swelling and pain and safely and effectively Chinese herbal medicine oral care product, also meets modern humans to the concept of natural green environmental protection and requirement.
Summary of the invention
The problem that the present invention solves is to provide compound Chinese medicine extract and is preparing the application scheme in oral cavity nursing health products, and this oral cavity nursing health products has obvious anti-inflammation hemostasia effect.
Compound Chinese medicine extract of the present invention is exactly joined in the oral cavity nursing health products such as toothpaste, collutory, dentifrice, throat lozenge, chewing gum by the ancillary drug raw material of compound Chinese medicine extract as anti-inflammation hemostasia effect in the technique preparing oral cavity nursing health products preparing the application scheme in oral cavity nursing health products, and described compound Chinese medicine extract is Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract.
In technique scheme, Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract join in toothpaste as the ancillary drug raw material of anti-inflammation hemostasia effect, the percentage by weight of these four kinds of extracts in total mastic of toothpaste is 2-15%, and described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract are than being 0.5:2:2:3.
In technique scheme, described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract join in collutory as the ancillary drug raw material of anti-inflammation hemostasia effect, the percentage by weight of these four kinds of extracts in collutory raw material is 2-15%, and described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract are than being 0.5:2:2:3.
In technique scheme, described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract join in dentifrice as the ancillary drug raw material of anti-inflammation hemostasia effect, the percentage by weight of these four kinds of extracts in dentifrice raw material is 2-15%, and described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract are than being 0.5:2:2:3.
In technique scheme, described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract join in throat lozenge as the ancillary drug raw material of anti-inflammation hemostasia effect, the percentage by weight of these four kinds of extracts in throat lozenge raw material is 2-15%, and described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract are than being 0.5:2:2:3.
In technique scheme, described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract join in chewing gum as the ancillary drug raw material of anti-inflammation hemostasia effect, the percentage by weight of these four kinds of extracts in chewing-gum material is 2-5%, and described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract are than being 0.5:2:2:3.
The said Radix Zanthoxyli of the present invention is the dry root of rutaceae Radix Zanthoxyli Zanthoxylumnitidum (Roxb.) DC..Nature and flavor are bitter, pungent, flat; Slightly poisonous. return liver, stomach warp.Function is blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, dispelling wind and removing obstruction in the collateral, removing toxic substances and promoting subsidence of swelling.For injury from falling down, stomachache, toothache, rheumatic arthralgia, venom; Externally treating burns and scalds.
Herba Leonuri of the present invention is the fresh or dry aerial parts of labiate Herba Leonuri LeonurusjaponicusHoutt..Nature and flavor are bitter, pungent, are slightly cold.Return liver, pericardium, urinary bladder channel.Function is promoting blood flow to regulate menstruation, inducing diuresis to remove edema, heat-clearing and toxic substances removing.For menoxenia, dysmenorrhea amenorrhea, lochiorrhea, edema oliguria, sore swollen toxin.
Fructus Gardeniae of the present invention is the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae GardeniajasminoidesEllis.Nature and flavor are bitter, cold.GUIXIN, lung, tri-jiao channel.Function is pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; Externally used detumescence pain relieving.Vexed for calentura, jaundice due to damp-heat, the puckery pain of stranguria, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.
Herba Centellae of the present invention is the dry herb of samphire Herba Centellae Centellaasiatica (L.) Urb..Nature and flavor bitter, acrid, cold, returns liver,spleen,kidney warp.Function is clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.For jaundice due to damp-heat, heatstroke is suffered from diarrhoea, stranguria caused by urinary stone stranguria with blood, carbuncle sore tumefacting virus, injury from falling down.
Mouth care health product of the present invention add the raw material not only use safety of compound Chinese medicine extract as natural plant active component in preparation process, and have obvious anti-inflammation hemostasia effect.
Be use with the form of compound Chinese medicine extract in the present invention, its extracting method is by broken for herbal mixture granulating, extracts 3 hours, extract 3 times, then extracting solution concentrating under reduced pressure is dried to powdery with the alcohol heating reflux of 10 times amount.The extracting method of herbal mixture is not limited to said method, and the additive method such as supercritical extraction, ultrasonic extraction also can be adopted to extract.
The content of the herbal mixture described in the present invention is all the pure extract powder of 100% for active component, but is not limited to pure extract powder, also can be other form such as extracting solution or extractum.In time being applied to oral care product with other forms as extracting solution, the addition in formula should be converted to the amount of pure form of extract disclosed in the present invention.
The present invention confirms through pharmacological evaluation, and the oral care product of herbal mixture has significant anti-inflammation hemostasia effect, can be used for preparing oral cavity composition.
The present invention carries out clinical trial checking to the toothpaste containing herbal mixture.Experimental result shows, this herbal mixture toothpaste effectively can treat the gingival swelling and pain hemorrhage of patient.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.In following each embodiment, involved percentage ratio except as otherwise noted, is all calculate by weight percentage.
Embodiment 1 ~ 5: Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract are as the application of compound Chinese medicine extract in toothpaste, and described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract are than being 0.5:2:2:3.
Toothpaste constitutive material in embodiment 1 to embodiment 5 and weight percent content are as following table 1:
In the present embodiment 3, lotion of toothpaste adopts the one-step method cream production technology of conventional medicine toothpaste to make: in temporary cylinder, drop into the liquid material such as pure water, sorbitol, compound Chinese medicine extract measured; In pre-dispersed still, drop into the calcite in powder, saccharin sodium, carboxycellulose sodium, sodium lauryl sulphate, the nipalgin that measure mix the powders such as ester sodium, carry out pre-dispersed, mixing; Open cream still vacuum pump processed and suck above-mentioned liquid material; Then open scraper, enter above-mentioned powder, drive agitator and colloid mill, after 30 minutes, drop into essence, close colloid mill, agitator, scraper successively after 10 minutes, vacuum breaker, stop vacuum pump, make after sampling detection is qualified.
The production technology of the lotion of toothpaste of other embodiment above-mentioned is with reference to embodiment 3.
Embodiment 6 ~ 10: Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract are as the application of compound Chinese medicine extract in collutory, and described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract are than being 0.5:2:2:3.
Collutory constitutive material in embodiment 6 to embodiment 10 and weight percent content are as following table 2:
In the present embodiment 8, first compound Chinese medicine extract, nipalgin mixed ester sodium are added stirring and dissolving in edible ethanol and is placed in temporary pot, sorbitol, deionization, castor oil hydrogenated-40 are added in agitated kettle and stirs 10 minutes, alcoholic solution in temporary pot is added in agitated kettle and stir 10 minutes, finally add essence and stir 5 minutes, stop stirring, make after sampling detection is qualified.
The collutory production technology of other embodiment above-mentioned is with reference to embodiment 8.
Embodiment 11 ~ 15: Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract are applied in dentifrice as compound Chinese medicine extract, described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract are than being 0.5:2:2:3.
Dentifrice constitutive material in embodiment 11 to embodiment 15 and weight percent content are as following table 3:
In the present embodiment 13; natural whiting, sodium carboxymethyl cellulose, sodium lauryl sulphate, saccharin sodium are added after weighing up by formula consumption in mixing agitator to stir and add compound Chinese medicine extract after 20 minutes and stir 10 minutes; finally add essence, sorbitol stir after 20 minutes shut down, sampling detect qualified after make.
The production technology of the dentifrice of other embodiment above-mentioned is with reference to embodiment 11.
Embodiment 16 ~ 20: multiple Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract are as the application of compound Chinese medicine extract in throat lozenge, and described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract are than being 0.5:2:2:3.
Throat lozenge constitutive material in embodiment 16 to embodiment 20 and weight percent content are as following table 4:
The preparation technology of the present embodiment 16 ~ 20 adopts existing throat lozenge production technology.
Embodiment 21 ~ 25: multiple Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract are as the application of compound Chinese medicine extract in chewing gum, and described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract are than being 0.5:2:2:3.
Chewing gum constitutive material in embodiment 21 to embodiment 25 and weight percent content are as following table 5:
The preparation technology of the present embodiment 21 ~ 25 adopts the production technology of existing chewing gum.
Clinical experiment part:
Gingival swelling and pain bleeding patients is used and treats containing herbal composite extract toothpaste sample, process of the test and result as follows:
1, case selection: simple gingivitis; Antibiotics is not taken in two weeks; Periodontal treatment is not carried out healthy in 3 months; Tested period, do not use other toothpaste and take antibiotics.
Qualified 150 patients of Stochastic choice.Experiment point 5 groups of each 30 people.20 ~ 64 years old age, average 42 years old.
2, Experimental agents and administrated method: first group uses the toothpaste containing this compound Chinese medicine extract, other Four composition do not use different shiny pricklyash toothpastes, five groups of experimental subject unified use soft bristle tooth brushes, by perpendicular brush method, every day sooner or later respectively once, each consumption is 2 grams (about extruding long 1.5 centimeters of toothpaste), brushes teeth 3 minutes at every turn.
3, observational technique and index: do clinical examination record in 30 days respectively at before use toothpaste and after using toothpaste, comprising: record patient chief complaint, as gingival hemorrhage, redness, halitosis etc., the change before and after toothpaste uses.Every obvious tooth of patient's observation panel intracavity inflammation 6, tooth position does not specify.Observation index: gingival index (GI), plaque index (PLI).
4, efficacy evaluation:
(GI) × 100% before (GI)-use rear (GI)/use before gingival index (GI) effective percentage (%)=use
Plaque index PLI) (PLI) × 100% before (PLI) after (PLI) before effective percentage (%)=use-use/use
Result: the comparison (see table 6) of the 5 groups of every average indexs of gingivitis in medication 30 days front and back
Table 6: the comparison of the 5 groups of every average indexs of gingivitis in medication 30 days front and back
Upper table illustrates, 5 groups of experimenters use 5 groups of different Radix Zanthoxyli medicated toothpaste after 30 days, and 1 group uses rear gingival index effective percentage to be 48.5%, dental plaque index 51.4%, and therapeutic effect is good, uses corresponding toothpaste apparently higher than all the other 4 groups of experimenters.All the other four groups of toothpaste also obtain certain curative effect.
Claims (5)
1. compound Chinese medicine extract is preparing the application in toothpaste technique, namely add in toothpaste using compound Chinese medicine extract as the ancillary drug raw material of anti-inflammation hemostasia effect preparing in toothpaste technique, described compound Chinese medicine extract is Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract; Described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, the Herba Centellae extract percentage by weight in total mastic of toothpaste is 2-15%, and described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract are than being 0.5:2:2:3.
2. compound Chinese medicine extract is preparing the application in collutory technique, namely add in collutory using compound Chinese medicine extract as the ancillary drug raw material of anti-inflammation hemostasia effect preparing in collutory technique, described compound Chinese medicine extract is Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract; Described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, the Herba Centellae extract percentage by weight in collutory is 2-15%, and described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract are than being 0.5:2:2:3.
3. compound Chinese medicine extract is preparing the application in dentifrice technique, namely add in dentifrice using compound Chinese medicine extract as the ancillary drug raw material of anti-inflammation hemostasia effect preparing in dentifrice technique, described compound Chinese medicine extract is Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract; Described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, the Herba Centellae extract percentage by weight in dentifrice is 2-15%, and described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract are than being 0.5:2:2:3.
4. compound Chinese medicine extract is preparing the application in throat lozenge technique, namely add in throat lozenge using compound Chinese medicine extract as the ancillary drug raw material of anti-inflammation hemostasia effect preparing in throat lozenge technique, described compound Chinese medicine extract is Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract; Described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, the Herba Centellae extract percentage by weight in throat lozenge is 2-15%, and described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract are than being 0.5:2:2:3.
5. compound Chinese medicine extract is preparing the application in chewing gum technique, namely add in chewing gum using compound Chinese medicine extract as the ancillary drug raw material of anti-inflammation hemostasia effect preparing in chewing gum technique, described compound Chinese medicine extract is Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract; Described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, the Herba Centellae extract percentage by weight in chewing gum is 2-15%, and described Radix Zanthoxyli extract, Herba Leonuri extract, Fructus Gardeniae extract, Herba Centellae extract are than being 0.5:2:2:3.
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| CN104873632B (en) * | 2015-05-20 | 2018-04-03 | 柳州两面针股份有限公司 | Application of the compound Chinese medicine extract in oral cavity nursing health products are prepared |
| CN104887569A (en) * | 2015-05-26 | 2015-09-09 | 柳州市亿廷贸易有限责任公司 | Mouth wash |
| CN105053492A (en) * | 2015-07-14 | 2015-11-18 | 界首市兆龙食品有限公司 | Anti-allergy chewing gum |
| CN105106061A (en) * | 2015-08-26 | 2015-12-02 | 施如涛 | Traditional Chinese medicine toothpaste containing calamine |
| CN105434264B (en) * | 2015-12-22 | 2018-06-29 | 南昌理工学院 | A kind of motherwort toothpaste |
| CN105726407B (en) * | 2016-03-28 | 2018-06-01 | 两面针（江苏）实业有限公司 | A kind of preparation method for combination of brushing teeth |
| CN109864966A (en) * | 2019-04-25 | 2019-06-11 | 明光市昊昊蜂业有限公司 | A kind of Chinese medicine compound prescription mouthwash and preparation method thereof |
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