CN105055230A - Multifunctional Chinese medicinal toothpaste composition, toothpaste prepared from composition and preparation method of toothpaste - Google Patents
Multifunctional Chinese medicinal toothpaste composition, toothpaste prepared from composition and preparation method of toothpaste Download PDFInfo
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Abstract
The invention relates to multifunctional Chinese medicinal toothpaste composition. The composition comprises Chinese herb extracts, wherein the Chinese herb extracts comprise components in parts by mass as follows: 0.1-5 parts of hairyvein agrimonia herb and bud extracts, 0.05-4 parts of philippine violet herb extracts, 0.05-3 parts of wild chrysanthemum extracts and 0.05-4 parts of dandelion extracts. The invention provides toothpaste prepared from the composition and a preparation method of the toothpaste. The toothpaste can effectively clean teeth and keep the mouth fresh, also has the efficacy of hemostasis, pain relieving, detumescence, apocenosis, heat and toxic material clearing, antisepsis, anti-inflammation, oxidation resistance and allergy resistance and can remarkably relieve, inhibit and treat dental ulcer, gingival bleeding, tooth ache, throat pain, mumps and other diseases. Besides, the toothpaste can also be used for face cleaning and applied to the surface of skin.
Description
Technical field
The invention belongs to cosmetics of everyday use field, particularly a kind of multi-function Chinese medicinal toothpaste compositions and toothpaste thereof and preparation method.
Background technology
Toothpaste, as a kind of daily necessities, is used from cleaning teeth with toothbrush one, protection oral hygiene, uses toothpaste that bacterial plaque and bur can be made to produce the effects such as dissolving, decomposition, neutralization, thus effectively ensures the health in tooth and oral cavity.
The toothpaste great majority sold in the market are allocated by several simple industrial chemicals to form (wetting agent, thickening agent, abrasive, sweeting agent, coloring agent etc.).Although various in style, can only cleaning teeth, keep oral cavity refreshing, the most toothpaste series of products wherein market existed, mainly by the publicity of TV, advertisement, star, exaggerate its effect and effect, thus win the trust of our consumer; But its product cannot really realize suppressing the growth of oral cavity bacterium or direct bactericidal antiphlogistic, can not reach the health purpose effectively ensureing Buccodental.
China is vast in territory, natural Chinese medicinal herb aboundresources, and in recent years, the Chinese government advocates encourage growth, researchs and produces herbal product, to meet the need of market, can promote that China's biotechnology is further developed simultaneously.Therefore the product being main additive with Chinese herbal medicine extract has safety, gentle, healthy advantage, existing market there is the toothpaste be prepared from by Chinese medicine formula, as Radix Zanthoxyli, Herba Pileae Scriptae, Luclean (adding Folium Camelliae sinensis extract tea polyphenols), six must be controlled etc.And for example disclosed in patent CN104800141A, a kind of Chinese medicine removes stain whitening toothpaste and preparation method thereof, is added with the Chinese medicine ingredients of Rhizoma Phragmitis, Cornu Bubali, Flos Lonicerae, Fructus Trichosanthis, Semen Cassiae and Radix Angelicae Dahuricae (Radix Heraclei Scabridi); For another example a kind of Chinese medicinal toothpaste and preparation method thereof disclosed in patent CN104688630A, its Chinese crude drug adopts tens tastes such as Rhizoma Imperatae, three phases, Flos Lonicerae, Herba Menthae Haplocalycis.Although these products can cleaning teeth effectively; keep oral cavity fresh and cool, pleasant; but the Chinese medicine additive composition in product is almost very little; and raw material of Chinese medicine composition is not too single is exactly too complicated; do not reach the object of the growth that effectively suppresses oral cavity bacterium or direct bactericidal antiphlogistic, our oral hygiene cannot be made, the health of tooth better protected.
Summary of the invention
In order to solve the problems of the technologies described above, the invention provides a kind of multi-function Chinese medicinal toothpaste compositions and this toothpaste.This toothpaste can effective cleaning teeth, keeps oral cavity pleasant, has effect of hemostasis and pain-relieving, detumescence and apocenosis, heat-clearing and toxic substances removing, anti-inflammation, antioxidation and antiallergic simultaneously; To oral ulcer, gingival hemorrhage, dental pain, have sore throat, the slight illness such as parotitis has obvious alleviation, suppression and curative effect; In addition, the toothpaste that prepared by said composition and compositions also can be used for clean, skin wound surface spreading.
The invention provides a kind of multi-function Chinese medicinal toothpaste compositions, described compositions includes Chinese medicine extract, and described Chinese medicine extract forms primarily of the component of following masses number: Herba Agrimoniae extract 0.1-5, Herba Violae extract 0.05-4, Flos Chrysanthemi Indici extract 0.05-3, Herba Taraxaci extract 0.05-4.
Said extracted thing is respectively the direct water extraction of its corresponding raw material of Chinese medicine, alcohol extraction or is extracted by microwave extraction, ultrasonic assistant, also directly can use commercially available each extract.
In one of them scheme, taking parts by weight is: after the dry product raw material pulverizing of Herba Agrimoniae 18, purple DIHUA fourth 6, Flos Chrysanthemi Indici 4 and Herba Taraxaci 6, add the alcohol reflux twice of 8 times amount 60%, 2h/ time, merging filtrate, drying under reduced pressure, obtains Chinese medicine extract.
In another scheme, separately extracted by each raw material of Chinese medicine, extraction step is:
A. Herba Agrimoniae extract adopts following methods to prepare: by 60 sieves of looking over so as to check after Herba Agrimoniae drying and crushing, add the water of Hairyvein Agrimonia Herd quality 80 times, carry out ultrasonic extraction, extracts power 520W, extraction time 20min, sucking filtration; Filtering residue adds water and repeats to extract once, and sucking filtration, merges twice filtrate, is drying to obtain Herba Agrimoniae extract powder after concentrating under reduced pressure;
B. Herba Violae extract adopts following methods to prepare: Herba Violae drying and crushing crosses 60 mesh sieves, add 75% ethanol and zeolite, be placed in container, put into microwave oven, adjusting power is 1200W, microwave radiation 14s, taking-up lucifuge cools, and repeats microwave 2 times, by centrifugal for the extracting solution after microwave, get supernatant liquid extraction, after concentrated, be drying to obtain Herba Violae extract powder;
C. Flos Chrysanthemi Indici extract adopts following methods to prepare: after Flos Chrysanthemi Indici drying and crushing crosses 60 mesh sieves, add 95% ethanol, ultrasonic extraction 25min, sucking filtration; Filtering residue adds 95% ethanol and repeats ultrasonic extraction once, and sucking filtration, merges twice filtrate, and after decompression recycling ethanol, namely concentrate drying obtains Flos Chrysanthemi Indici extract powder;
D. Herba Taraxaci extract adopts following methods to prepare: by 60 sieves of looking over so as to check after Herba Taraxaci drying and crushing, add the methanol of Herba Taraxaci powder quality 20 times, carry out ultrasonic extraction, extraction time 10min, sucking filtration; Filtering residue adds water and repeats to extract once, and sucking filtration, merges twice filtrate, is drying to obtain Herba Taraxaci extract powder after concentrating under reduced pressure;
E. merge each extract powder of above-mentioned steps, obtain Chinese medicine extract.
In compositions of the present invention, the main component of Herba Agrimoniae extract is agrimophol, Herba Agrimoniae lipid, glycoside etc., and it coordinates Flos Chrysanthemi Indici extract to use, and has good anti-inflammation and sterilization effect, has again refreshment, lax neural effect simultaneously; Simultaneously in conjunction with purple DIHUA fourth extract and Herba Taraxaci extract, compositions of the present invention is made to have splendid heat clearing away, detumescence, antiinflammation; Research shows, Herba Agrimoniae extract and Herba Violae extract all have obvious bacteriostasis.The multi-function dentifrice composition that above-mentioned a few herbs extract coordinates, composition safety, the property of medicine are gentle, have obvious alleviation, suppression and curative effect to oral ulcer, gingival hemorrhage, dental pain, laryngopharynx swelling and pain, parotitis etc.
The effect of dentifrice composition anti-inflammation of the present invention is remarkable, and described compositions also comprises α-bisabolol that parts by weight are 0.04-2.7.α-bisabolol is a kind of composition be present in bluish yellow Flos Chrysanthemi; there is the effect of anti-inflammation; add the antibacterial and anti-inflammation functions that this composition strengthens the present composition further; research shows; by adding α-bisabolol, compositions character is stablized; make the present composition have good skin-friendliness, can be used as the protection of the active component with nursing allergic skin.
Preferred further, the parts by weight of described α-bisabolol are 0.15-1.3.Preferred α-bisabolol is natural (-)-a-bisabolol, the antiinflammatory of (-)-a-bisabolol and spasmolytic effect all compared with (+)-a-bisabolol and (+-)-a-bisabolol stronger.
For more reasonably configuring compositions of the present invention, play better effect, described Chinese medicine extract is made up of the component of following masses number: Herba Agrimoniae extract 0.4-1.5, Herba Violae extract 0.1-1.2, Flos Chrysanthemi Indici extract 0.1-1, Herba Taraxaci extract 0.1-1.2.
Present invention also offers a kind of toothpaste be prepared from by above-mentioned composition and adjuvant, described toothpaste is prepared from by compositions, adjuvant and deionized water, described adjuvant comprises abrasivus, thickening agent, wetting agent, foaming agent, sweeting agent, regulator, essence and antiseptic, and the parts by weight of the component contained in described toothpaste are:
Further, described abrasivus is one or both in calcium carbonate or silicon dioxide; Described thickening agent is one or more in sodium carboxymethyl cellulose, hydroxy methocel, xanthan gum or carbomer; Described wetting agent is one or more in Sorbitol, PEG-8 or glycerol; Described foaming agent is one or more in sodium lauryl sulfate, sodium lauroyl sarcosine or sodium cocoyl glycinate; Described sweeting agent is one or more in saccharin sodium, cyclamate or sucralose; Described regulator is one or more in mineral salt, tetrasodium pyrophosphate or tertiary sodium phosphate; Described essence is menthol essence; Described antiseptic is one or more in methyl hydroxybenzoate, propyl hydroxybenzoate or sodium benzoate.Wherein, when preferred foaming agent is the composite use of sodium lauryl sulfate and sodium cocoyl glycinate, zest is minimum, and safety is good and can improve foaming effect.
Further, described abrasivus is the mixture of calcium carbonate and silicon dioxide; Described thickening agent is the mixture of hydroxy methocel, xanthan gum and carbomer; Described wetting agent is Sorbitol; Described foaming agent is sodium lauryl sulfate; Described sweeting agent is saccharin sodium; Described regulator is tertiary sodium phosphate; Described essence is menthol essence; Described antiseptic is the mixture of methyl hydroxybenzoate and propyl hydroxybenzoate; The parts by weight of the component contained in toothpaste are:
Further reasonable disposition, the parts by weight of the component contained in described toothpaste are
Wherein, described compositions is prepared from by the raw material of following parts by weight:
The present invention provides a kind of preparation method of toothpaste on the other hand, and the method comprises the steps:
A. Chinese medicine extract is dissolved in the deionized water of 10 times amount, forms Chinese medicine extract aqueous solution; Saccharin sodium is dissolved in the deionized water of 10 times amount, forms saccharin sodium aqueous solution; Tertiary sodium phosphate is dissolved in the deionized water of 10 times amount, forms trisodium phosphate aqueous solution;
B. Sorbitol, α-bisabolol, hydroxy methocel, xanthan gum, lauryl alcohol sulfuric acid ester sodium mix homogeneously are delivered to vacuum Manufacturing medicine extract machine, maintenance vacuum is-0.6 ~-0.9mpa, starts agitator simultaneously and stirs; Chinese medicine extract aqueous solution, saccharin sodium aqueous solution, trisodium phosphate aqueous solution, balance deionized water to be sent into successively in vacuum Manufacturing medicine extract machine and to stir;
C. get in PH reagent paper or special PH acid-base meter insertion water liquid, measure solution acid alkalinity, and pH value is adjusted to 5.5-6.5;
D., after adjusting pH value, calcium carbonate added vacuum Manufacturing medicine extract machine and stir homogenizing, under vacuum is-0.85 ~-0.98mpa, adding menthol essence, carbomer, methyl hydroxybenzoate and propyl hydroxybenzoate, and after stirring 5-8 minute, fill, obtains toothpaste.
Further aspect of the present invention provides the application of above-mentioned composition in the toothpaste for the preparation of hemostasis and pain-relieving, detumescence and apocenosis and treatment dental gingival inflammation, ulcer.
Multi-function Chinese medicinal toothpaste compositions provided by the present invention and this toothpaste, can effective cleaning teeth, keeps that oral cavity is suitable feels well.There is hemostasis and pain-relieving, detumescence and apocenosis, heat-clearing and toxic substances removing, anti-inflammation simultaneously, antioxidation, anti-allergic effects; To oral ulcer, gingival hemorrhage, dental pain, laryngopharynx swelling and pain, parotitis etc., there is obvious alleviation, suppression and curative effect.The effects such as the compositions of adding α-bisabolol also can be used as clean, skin wound surface application.In addition, gentle by adding the toothpaste character prepared of adjuvant, zest is low and have good foaming capacity.
Compositions of the present invention also can be used as clean agent, application or liniment, can remove grease on the face as clean agent, and sun-proof, anti-skin allergy, removes aging skin, goes freckle, keeps skin beauty water on the face to grade, and makes skin pleasant, moistening, smooth.For skin wound surface application to knife injury, hemorrhage, pain, burn, worm venom, eczema, tinea pedis etc. have and obviously suppress and curative effect.And liniment can be used for rubbing temple and can prevent headache, dizzy etc., play the effect of analgesia, antiinflammatory, refreshment.Functions such as removing raw meat simultaneously in addition, go stain, derust.
The source of crude drug of the present invention is as follows:
Herba Agrimoniae: this product is the dry aerial parts of rosaceous plant Radix Agrimoniae AgrimoniapilosaLedeb..
Herba Violae: this product is the dry herb of Violaceae Chinese violet ViolayedoensisMakino.
Flos Chrysanthemi Indici: this product is the dry capitulum of feverfew Herba Dendranthematis indici ChrysanthemumindicumL..
Herba Taraxaci: this product is feverfew Herba Taraxaci TaraxacummongolicumHand.-Mazz., alkali ground Herba Taraxaci TaraxacumsinicumKitag. or belong to the dry herb of several plants together
Detailed description of the invention
Embodiment 1 compositions
Embodiment 2 compositions
Embodiment 3 compositions
Preparation method:
A. described Herba Agrimoniae extract adopts following methods to prepare: by 60 sieves of looking over so as to check after Herba Agrimoniae drying and crushing, add the water of Hairyvein Agrimonia Herd quality 80 times, carry out ultrasonic extraction, extracts power 520W, extraction time 20min, sucking filtration; Filtering residue adds water and repeats to extract once, and sucking filtration, merges twice filtrate, be drying to obtain after concentrating under reduced pressure;
B. described Herba Violae extract adopts following methods to prepare: Herba Violae drying and crushing crosses 60 mesh sieves, add 75% ethanol and zeolite, be placed in container, put into microwave oven, adjusting power is 1200W, microwave radiation 14s, taking-up lucifuge cools, and repeats microwave 2 times, by centrifugal for the extracting solution after microwave, get supernatant liquid extraction, be drying to obtain after concentrated;
C. described Flos Chrysanthemi Indici extract adopts following methods to prepare: after Flos Chrysanthemi Indici drying and crushing crosses 60 mesh sieves, add 95% ethanol, ultrasonic extraction 25min, sucking filtration; Filtering residue adds 95% ethanol and repeats ultrasonic extraction once, and sucking filtration, merges twice filtrate, after decompression recycling ethanol, and concentrate drying and get final product;
D. described Herba Taraxaci extract adopts following methods to prepare: by 60 sieves of looking over so as to check after Herba Taraxaci drying and crushing, add the methanol of Herba Taraxaci powder quality 20 times, carry out ultrasonic extraction, extraction time 10min, sucking filtration; Filtering residue adds water and repeats to extract once, and sucking filtration, merges twice filtrate, be drying to obtain after concentrating under reduced pressure;
E. each extraction of above-mentioned preparation is merged and obtains compositions.
Embodiment 4 compositions
Embodiment 5 compositions
Preparation method: above-mentioned each extract and α-bisabolol are the powder that market is buied, takes each extract of described weight portion and the powder of α-bisabolol, merges and obtain compositions.
Embodiment 6 compositions
The preparation method of each component: prepare by the method for embodiment 5.
Embodiment 7 compositions
The preparation method of each component: prepare by the method for embodiment 5.
Embodiment 8 compositions
The preparation method of each component: prepare by the method for embodiment 5.
Embodiment 9 toothpaste
Preparation method:
A. Chinese medicine extract is dissolved in the deionized water of 10 times amount, forms Chinese medicine extract aqueous solution; Cyclamate is dissolved in the deionized water of 10 times amount, forms cyclamate aqueous solution; Tetrasodium pyrophosphate is dissolved in the deionized water of 10 times amount, forms tetrasodium pyrophosphate aqueous solution;
B. cyclamate, hydroxy methocel, sodium lauryl sulphate and lauryl alcohol sulfuric acid ester sodium mix homogeneously are delivered to vacuum Manufacturing medicine extract machine, maintenance vacuum is-0.7mpa, starts agitator simultaneously and stirs; Chinese medicine extract aqueous solution, cyclamate aqueous solution, tetrasodium pyrophosphate aqueous solution, balance deionized water to be sent into successively in vacuum Manufacturing medicine extract machine and to stir;
C. get in PH reagent paper or special PH acid-base meter insertion water liquid, measure solution acid alkalinity, and pH value is adjusted to 5.5-6.5;
D., after adjusting pH value, calcium carbonate and silicon dioxide added vacuum Manufacturing medicine extract machine and stirs homogenizing, under vacuum is-0.92mpa, adding menthol essence, carbomer, methyl hydroxybenzoate, and after stirring 5-8 minute, fill, obtains toothpaste.
Embodiment 10 toothpaste
Preparation method:
A. Chinese medicine extract is dissolved in the deionized water of 10 times amount, forms Chinese medicine extract aqueous solution; Saccharin sodium is dissolved in the deionized water of 10 times amount, forms saccharin sodium aqueous solution; Tertiary sodium phosphate is dissolved in the deionized water of 10 times amount, forms trisodium phosphate aqueous solution;
B. Sorbitol, hydroxy methocel, xanthan gum, lauryl alcohol sulfuric acid ester sodium mix homogeneously are delivered to vacuum Manufacturing medicine extract machine, maintenance vacuum is-0.87mpa, starts agitator simultaneously and stirs; Chinese medicine extract aqueous solution, saccharin sodium aqueous solution, trisodium phosphate aqueous solution, balance deionized water to be sent into successively in vacuum Manufacturing medicine extract machine and to stir;
C. get in PH reagent paper or special PH acid-base meter insertion water liquid, measure solution acid alkalinity, and pH value is adjusted to 5.5-6.5;
D., after adjusting pH value, calcium carbonate and silicon dioxide added vacuum Manufacturing medicine extract machine and stirs homogenizing, under vacuum is-0.88mpa, adding menthol essence and methyl hydroxybenzoate, and after stirring 5-8 minute, fill, obtains toothpaste.
Embodiment 11 toothpaste
Preparation method:
A. Chinese medicine extract is dissolved in the deionized water of 10 times amount, forms Chinese medicine extract aqueous solution; Saccharin sodium is dissolved in the deionized water of 10 times amount, forms saccharin sodium aqueous solution; Tertiary sodium phosphate is dissolved in the deionized water of 10 times amount, forms trisodium phosphate aqueous solution;
B. Sorbitol, α-bisabolol, hydroxy methocel, xanthan gum, lauryl alcohol sulfuric acid ester sodium mix homogeneously are delivered to vacuum Manufacturing medicine extract machine, maintenance vacuum is-0.6mpa, starts agitator simultaneously and stirs; Chinese medicine extract aqueous solution, saccharin sodium aqueous solution, trisodium phosphate aqueous solution, balance deionized water to be sent into successively in vacuum Manufacturing medicine extract machine and to stir;
C. get in PH reagent paper or special PH acid-base meter insertion water liquid, measure solution acid alkalinity, and pH value is adjusted to 5.5-6.5;
D., after adjusting pH value, calcium carbonate and silicon dioxide added vacuum Manufacturing medicine extract machine and stirs homogenizing, under vacuum is-0.85mpa, adding menthol essence, carbomer, methyl hydroxybenzoate and propyl hydroxybenzoate, and after stirring 5-8 minute, fill, obtains toothpaste.
Embodiment 12 toothpaste
Preparation method:
A. Chinese medicine extract is dissolved in the deionized water of 10 times amount, forms Chinese medicine extract aqueous solution; Saccharin sodium is dissolved in the deionized water of 10 times amount, forms saccharin sodium aqueous solution; Tertiary sodium phosphate is dissolved in the deionized water of 10 times amount, forms trisodium phosphate aqueous solution;
B. Sorbitol, α-bisabolol, hydroxy methocel, xanthan gum, lauryl alcohol sulfuric acid ester sodium mix homogeneously are delivered to vacuum Manufacturing medicine extract machine, maintenance vacuum is-0.85mpa, starts agitator simultaneously and stirs; Chinese medicine extract aqueous solution, saccharin sodium aqueous solution, trisodium phosphate aqueous solution, balance deionized water to be sent into successively in vacuum Manufacturing medicine extract machine and to stir;
C. get in PH reagent paper or special PH acid-base meter insertion water liquid, measure solution acid alkalinity, and pH value is adjusted to 5.5-6.5;
D., after adjusting pH value, calcium carbonate and silicon dioxide added vacuum Manufacturing medicine extract machine and stirs homogenizing, under vacuum is-0.98mpa, adding menthol essence, carbomer, methyl hydroxybenzoate and propyl hydroxybenzoate, and after stirring 5-8 minute, fill, obtains toothpaste.
Embodiment 13 toothpaste
Preparation method: prepare according to the preparation method of embodiment 12.
Embodiment 14 toothpaste
Preparation method:
A. Chinese medicine extract is dissolved in the deionized water of 10 times amount, forms Chinese medicine extract aqueous solution; Saccharin sodium is dissolved in the deionized water of 10 times amount, forms saccharin sodium aqueous solution; Tertiary sodium phosphate is dissolved in the deionized water of 10 times amount, forms trisodium phosphate aqueous solution;
B. Sorbitol, α-bisabolol, hydroxy methocel, xanthan gum, lauryl alcohol sulfuric acid ester sodium and sodium cocoyl glycinate mix homogeneously are delivered to vacuum Manufacturing medicine extract machine, maintenance vacuum is-0.87mpa, starts agitator simultaneously and stirs; Chinese medicine extract aqueous solution, saccharin sodium aqueous solution, trisodium phosphate aqueous solution, balance deionized water to be sent into successively in vacuum Manufacturing medicine extract machine and to stir;
C. get in PH reagent paper or special PH acid-base meter insertion water liquid, measure solution acid alkalinity, and pH value is adjusted to 5.5-6.5;
D., after adjusting pH value, calcium carbonate and silicon dioxide added vacuum Manufacturing medicine extract machine and stirs homogenizing, under vacuum is-0.96mpa, adding menthol essence, carbomer, methyl hydroxybenzoate and propyl hydroxybenzoate, and after stirring 5-8 minute, fill, obtains toothpaste.
Embodiment 15 toothpaste
Preparation method:
A. Chinese medicine extract is dissolved in the deionized water of 10 times amount, forms Chinese medicine extract aqueous solution; Saccharin sodium is dissolved in the deionized water of 10 times amount, forms saccharin sodium aqueous solution; Tertiary sodium phosphate is dissolved in the deionized water of 10 times amount, forms trisodium phosphate aqueous solution;
B. Sorbitol, α-bisabolol, hydroxy methocel, xanthan gum, lauryl alcohol sulfuric acid ester sodium mix homogeneously are delivered to vacuum Manufacturing medicine extract machine, maintenance vacuum is-0.87mpa, starts agitator simultaneously and stirs; Chinese medicine extract aqueous solution, saccharin sodium aqueous solution, trisodium phosphate aqueous solution, balance deionized water to be sent into successively in vacuum Manufacturing medicine extract machine and to stir;
C. get in PH reagent paper or special PH acid-base meter insertion water liquid, measure solution acid alkalinity, and pH value is adjusted to 5.5-6.5;
D., after adjusting pH value, calcium carbonate and silicon dioxide added vacuum Manufacturing medicine extract machine and stirs homogenizing, under vacuum is-0.96mpa, adding menthol essence, carbomer, methyl hydroxybenzoate and propyl hydroxybenzoate, and after stirring 5-8 minute, fill, obtains toothpaste.
The stability test of test example 1 Chinese medicinal toothpaste
Adopt the Chinese medicinal toothpaste for preparing of embodiment 9 ~ 15, be placed in the baking oven of 50 DEG C respectively, observed whether fuel-displaced water outlet phenomenon of toothpaste every 15 days, whether outward appearance changes with color, whether toothpaste abnormal smells from the patient is consistent with temperature under room temperature.Observe 3 months, and record.
Result: fuel-displaced water outlet phenomenon does not all appear in the toothpaste of embodiment 9 ~ 15, and outward appearance and color do not change substantially, basically identical under toothpaste abnormal smells from the patient and room temperature; Wherein toothpaste and the original shape state under its room temperature of embodiment 10, abnormal smells from the patient are all consistent, and stability is best; Illustrate Chinese medicinal toothpaste of the present invention at high temperature under fish room temperature properties basically identical, totally all there is good stability.
Test example 2 Chinese medicinal toothpaste is on the impact of the therapeutic effect of oral cavity gingivitis, gingival hemorrhage and oral ulcer
1 experimenter and grouping:
1) alternative
1. age 18-65 year, remaining tooth >=16 tooth in mouth, without systemic disease, the normal simple gingivitis of routine blood test, platelet, clotting time and bleeding time; 2. do not use mouth cavity medicine or gargarism in 1 month, in 3 months, do not accept dental care.
2) grouping adopts multicenter random packet mode 80 experimenters to be divided into 4 groups (often organizing 20).
3) the Chinese medicinal toothpaste product that described in the embodiment of the present invention 1 of test specimen source, compositions described in compositions, embodiment 4 and embodiment 12 obtain, matched group is select commercially available LIUBIZHI YAGAO.
4) test method 7 days is one-period, totally 28 days, i.e. four cycles; Test group experimenter uses Chinese medicinal toothpaste to brush teeth every day 2 times, each 2-3g; Matched group experimenter brushes teeth 2 times with marketed drugs toothpaste every day, each 2-3g.
2 observation index
2.1 subjective symptoms
Show as red swelling of gingiva, hemorrhage, pain, halitosis, occlusion uncomfortable etc.;
Halitosis be divided into without, light, in, heavy; Slight halitosis: conscious halitosis, other people can't smell; Moderate halitosis: when speaking, other people can smell halitosis; Severe halitosis: time silent, other people can smell halitosis;
Gingiva pain is divided into nothing, light, neutralization is heavy.
2.2 clinical indexes
To subject oral cavity Fen Liuge district, free 6 tooth positions, are index tooth with 11,16,26,31,36,46 respectively, record the baseline plaque index (PLI) of each tooth, gingival index (GI) and gingival index (SBI).
A) plaque index (PLI) is proposed by Quigley and Hein1962, scoring 0 ~ 5.
Plaque index (PLI) scoring criteria:
0=Yin Yuan district is without bacterial plaque; The facing in 1=Yin Yuan district has thin bacterial plaque, but inspection is invisible, if can scrape bacterial plaque with the side of probe pinpoint; 2=is in gum edge or the visible moderate bacterial plaque of proximal surface; 3=gingival sulcus Nei Huoyinyuan district and proximal surface have a large amount of soft dirt.
B) gingival sulcus bleeding index (SBI), gingival index (GI)
Sulcular bleeding index (SBI) scoring criteria:
0=is completely healthy; 1=substantially healthy (gum edge and gum nipple are mild inflammation, not hemorrhage after light spy gingival sulcus); 2=gingivitis slight (gingiva is mild inflammation, has color change, without swelling or hematoma, visits and examines rear petechial hemorrhage); 3=gingivitis obviously (gingiva be moderate inflammation, has color change and Mild edema, and spy is examined rear hemorrhage, hemorrhage do not overflow gingival sulcus); 4=gingivitis heavier (gingiva is moderate inflammation, has color change, and has obvious tumefaction, visit examine rear hemorrhage and overflow gingival sulcus); 5=severe gingivitis (gingiva has color change, obvious tumefaction, sometimes has ulcer, and spy is examined rear hemorrhage or automatically hemorrhage).
Gingival index (GI) scoring criteria:
0=gums healthy; 1=gingiva mild inflammation (color of gingiva has MC and Mild edema, and spy is examined not hemorrhage); 2=gingiva moderate inflammation (gingiva color is red, edema light, and spy is examined hemorrhage); 3=gingiva extensive inflammation (gingiva is obviously red and swollen or have ulcer, and has automatic bleeding tendency).
2.3 observing times: experimenter all needs before using sample to do routine blood test, platelet, clotting time and bleeding time inspection, all observation items all need be checked by same doctor, and give record before use sample, after use sample for 7 days, 14 days, 21 days, 28 days successively.
3, curative effect determinate standard
According to subjective symptoms and clinical every observation index, be divided into recovery from illness, effective, take a turn for the better, invalid; Effective percentage=(recovery from illness number+effective number)/total case number × 100%.
Recovery from illness: symptom disappears completely, and every periodontal index is normally; Effective: subjective symptom is obviously improved, GI, PLI, SBI value decline >1, mobility of tooth reduces, and tooth is without kowtowing pain, and depth of pocket reduces 1mm; Take a turn for the better: symptom alleviates, gingival hemorrhage takes a turn for the better, and tooth kowtows alleviation of pain gently, has a decline in clinical periodontal index at least; Invalid: symptom and every periodontal index are all without improvement.
4, by test result
Before and after 4.1 gingivitis trier Chinese medicinal toothpastes, the change of the every exponential clinical sign of gingiva is in table 1;
Indices change before and after table 14 group gingivitis experimenter medication
Note:
represent average, s represents variance, and n represents number, and pain and halitosis are the quantity of test person.
4.2 triers use the comparitive study of Chinese medicinal toothpaste
Comparitive study before and after table 24 group gingivitis experimenter medication
Shown by the result of the test of table 1, table 2, after the Chinese medicinal toothpaste of the embodiment of the present invention 12 and embodiment 4 and the compositions described in embodiment 1 use 4 weeks, experimenter's bacterial plaque declines the most obvious, 90% is reached to the effective percentage of gingivitis, best results, subject oral cavity situation is: gingiva bacterial plaque formation rate has the reduction of significance, swelling and aching of gum, stores up symptom that is hemorrhage, halitosis and improves significantly; And the effect of matched group is poor.As from the foregoing, the toothpaste effect of not adding α-bisabolol is slightly poor, but is better than matched group toothpaste.
As can be seen from the above, Chinese medicinal toothpaste of the present invention has sterilization, antiinflammation, can bacteria growing inhibiting, removes dental plaque, and effectively can improve the problems such as gingival hemorrhage, gingiva pain, swelling and halitosis, and protection oral cavity, makes tooth whitening, health.
Claims (10)
1. a multi-function Chinese medicinal toothpaste compositions, it is characterized in that, described compositions includes Chinese medicine extract, and described Chinese medicine extract forms primarily of the component of following masses number: Herba Agrimoniae extract 0.1-5, Herba Violae extract 0.05-4, Flos Chrysanthemi Indici extract 0.05-3, Herba Taraxaci extract 0.05-4.
2. compositions as claimed in claim 1, it is characterized in that, described compositions also comprises α-bisabolol that parts by weight are 0.04-2.7.
3. compositions as claimed in claim 2, it is characterized in that, the parts by weight of described α-bisabolol are 0.15-1.3.
4. compositions as claimed in claim 1, it is characterized in that, described Chinese medicine extract is made up of the component of following masses number: Herba Agrimoniae extract 0.4-1.5, Herba Violae extract 0.1-1.2, Flos Chrysanthemi Indici extract 0.1-1, Herba Taraxaci extract 0.1-1.2.
5. the toothpaste that is prepared from of a compositions according to any one of claim 1-4 and adjuvant, it is characterized in that, described toothpaste is prepared from by compositions, adjuvant and deionized water, described adjuvant comprises abrasivus, thickening agent, wetting agent, foaming agent, sweeting agent, regulator, essence and antiseptic, and the parts by weight of the component contained in described toothpaste are:
6. toothpaste as claimed in claim 5, is characterized in that, described abrasivus is one or both in calcium carbonate or silicon dioxide; Described thickening agent is one or more in sodium carboxymethyl cellulose, hydroxy methocel, xanthan gum or carbomer; Described wetting agent is one or more in Sorbitol, PEG-8 or glycerol; Described foaming agent is one or more in sodium lauryl sulfate, sodium lauroyl sarcosine or sodium cocoyl glycinate; Described sweeting agent is one or more in saccharin sodium, cyclamate or sucralose; Described regulator is one or more in mineral salt, tetrasodium pyrophosphate or tertiary sodium phosphate; Described essence is menthol essence; Described antiseptic is one or more in methyl hydroxybenzoate, propyl hydroxybenzoate or sodium benzoate.
7. toothpaste as claimed in claim 6, it is characterized in that, described abrasivus is the mixture of calcium carbonate and silicon dioxide; Described thickening agent is the mixture of hydroxy methocel, xanthan gum and carbomer; Described wetting agent is Sorbitol; Described foaming agent is sodium lauryl sulfate; Described sweeting agent is saccharin sodium; Described regulator is tertiary sodium phosphate; Described essence is menthol essence; Described antiseptic is the mixture of methyl hydroxybenzoate and propyl hydroxybenzoate; The parts by weight of the component contained in described toothpaste are:
8. toothpaste as claimed in claim 7, it is characterized in that, the parts by weight of the component contained in described toothpaste are
Wherein, described compositions is prepared from by the raw material of following parts by weight:
9. a preparation method for toothpaste as claimed in claim 8, is characterized in that,
Described method comprises the steps:
A. Chinese medicine extract is dissolved in the deionized water of 10 times amount, forms Chinese medicine extract aqueous solution; Saccharin sodium is dissolved in the deionized water of 10 times amount, forms saccharin sodium aqueous solution; Tertiary sodium phosphate is dissolved in the deionized water of 10 times amount, forms trisodium phosphate aqueous solution;
B. Sorbitol, α-bisabolol, hydroxy methocel, xanthan gum, lauryl alcohol sulfuric acid ester sodium mix homogeneously are delivered to vacuum Manufacturing medicine extract machine, maintenance vacuum is-0.6 ~-0.9mpa, starts agitator simultaneously and stirs; Chinese medicine extract aqueous solution, saccharin sodium aqueous solution, trisodium phosphate aqueous solution, balance deionized water to be sent into successively in vacuum Manufacturing medicine extract machine and to stir;
C. get in PH reagent paper or special PH acid-base meter insertion water liquid, measure solution acid alkalinity, and pH value is adjusted to 5.5-6.5;
D., after adjusting pH value, calcium carbonate and silicon dioxide are added vacuum Manufacturing medicine extract machine and stirs homogenizing, under vacuum is-0.85 ~-0.98mpa, add menthol essence, carbomer, methyl hydroxybenzoate and propyl hydroxybenzoate, and after stirring 5-8 minute, fill, obtains toothpaste.
10. the application of compositions in the toothpaste for the preparation of hemostasis and pain-relieving, detumescence and apocenosis and treatment dental gingival inflammation, ulcer as described in as arbitrary in claim 1-4.
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