CN101933977B - Traditional Chinese medicine composition against tooth sensitivity, toothpaste and preparation method thereof - Google Patents
Traditional Chinese medicine composition against tooth sensitivity, toothpaste and preparation method thereof Download PDFInfo
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- CN101933977B CN101933977B CN 201010298277 CN201010298277A CN101933977B CN 101933977 B CN101933977 B CN 101933977B CN 201010298277 CN201010298277 CN 201010298277 CN 201010298277 A CN201010298277 A CN 201010298277A CN 101933977 B CN101933977 B CN 101933977B
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Abstract
The invention relates to a traditional Chinese medicine composition against tooth sensitivity and a preparation method of toothpaste containing the traditional Chinese medicine composition against the tooth sensitivity. Wherein the composition comprises the following traditional Chinese medicine components against the tooth sensitivity by weight percent: 20-70% of long pepper, 20-70% of sanchi, 5-50% of honeysuckle flower extract and 2-20% of calamine. The traditional Chinese medicine components against the tooth sensitivity can play the good anti-tooth sensitivity role and simultaneously have certain effects for tooth bleeding, gingival inflammation, swelling and pain and the like. The traditional Chinese medicine composition can be applied in the toothpaste, mouthwash, dentifrice, toothgel, chewing gums and other dental supplies.
Description
Technical field
The present invention relates to the Chinese medicine composition of anti-sensitivity of tooth, and a kind of preparation method that contains the Chinese medicine composition toothpaste of anti-sensitivity of tooth.
Background technology
Dental hypersensitiveness is perplexing people's daily life, and severe patient can cause other complications such as oral cavity, heart.The phenomenon that tooth is ached can occur when people take food acid, sugar water fruit or hot and cold food, this pain can be very sharp-pointed, unexpected, and gos deep into the teleneuron in the tooth.Dental hypersensitiveness claims again the sensitivity dentin, that tooth is subject to environmental stimuli, such as caused symptoms of aching such as temperature (hot and cold), chemical substance (acid, sweet) and mechanisms (rub or sting hard thing), its characteristics for outbreak rapidly, pain is sharp-pointed, the time is of short duration.At present, it be unclear that for the pathogenesis of dental hypersensitiveness, three kinds of theories are arranged.Neural theory, dentinal fibers conduction theory and fluid dynamic theory.Wherein the fluid theory it think that acting on Dentinal outside stimulus has caused inside or outside the flowing of dentinal tubule's content, thisly unusual mobilely be passed to dental pulp, thereby cause the excitement of Intradental nerve fiber, produce the pain sensation.Lower floor of odontoblast, odontoblast's layer and the intratubular nerve fiber of dentin internal layer are all very responsive to the mobile or unexpected pressure variation of liquid, and this also is the reason that dentin hypersensitiveness occurs.And another viewpoint is thought, the pathology essence of dentin hypersensitiveness can be counted as " odontoblastic process is scorching ".The natural pathological change process of dentin hypersensitiveness was divided into for three phases: ooze out the phase, the degeneration necrosis phase, the phase is repaired in calcification.Which kind of pathology theory no matter, dentin hypersensitiveness occur all be that open dentinal tubule causes and flows and excitation and the inflammation-related of dental pulp or canaliculi dentales nerve or endochylema.Thereby anti-sensitivity of tooth medicine generally is divided into Theory of Convergence Classes from pharmacological angle classification, filling class, calcification reparation class.Theory of Convergence Classes namely plays dehydration, solidifies dentin cell prominent or elimination Intradental nerve cellular inflammation and the excitation of exposure.The filling class forms gelatinous precipitate often in dentinal tubule, be combined but do not produce true property with tissue of tooth, and these precipitate may be washed away by saliva, so formulation rate is large, uses in clinical speciality dentistry but action effect is general multiplex rapidly.Class is repaired in calcification can make the hard tooth tissue remineralization, and the remineralization material is deposition and the open little tube passage of reparation slowly.Remineralization needs the time relatively long.In sum, three class medicines are because the mechanism of action is different, and action effect has his own strong points respectively shortage, because the cause of disease, the process of sensitivity of tooth are very complicated, therefore any medicine all can not be in full force and effect.Simultaneously, said medicine adopt more medicine type by oral, smear or dentist's specialty operation is implemented, can implement to reach medicable successful example seldom for the mode of daily oral care product.Trace it to its cause, may be because enforcement time of oral care product short, unstable active components, or other compositions cause drug effect interference etc.
Chinese medicine is the rarity that Traditional Chinese doctors ' is learnt to read and write.Motherland's medical science is thought, the generation of any disease, evolution all are that paathogenic factor acts on human body, and body yin or yang excessly declines partially, the result of internal organs meridian function imbalance and cause.Bias of medicine mainly contains four gas, the five tastes, lifting, reinforcing and reducing, return through, the poisonous aspect such as nontoxic.If the state of an illness is heavier, or state of an illness more complicated, single is used and is difficult to avoid untoward reaction, therefore often needs to use simultaneously two or more medicines.Medicine is used, can occur between medicine and the medicine some interact if any can strengthen or reduce original drug effect, what have can suppress or eliminate toxic and side effects, what have then can produce or strengthen toxicity.
Summary of the invention
The purpose of this invention is to provide particularly toothpaste and preparation method thereof of a kind of Chinese medicine composition of anti-sensitivity of tooth and oral care product.
The Chinese medicinal components of anti-sensitivity of tooth of the present invention by weight percentage said composition is composed of the following components:
Fructus Piperis Longi 20～70%, Radix Notoginseng 20～70%, Flos Lonicerae extract 5～50%, Calamina 2～20%.
In the Chinese medicine composition of above-mentioned anti-sensitivity of tooth, Fructus Piperis Longi is the main component that is used for the treatment of dentine hypersensitivity, and it can play the effect of paralysis dental nerve; Radix Notoginseng and Flos Lonicerae have good therapeutical effect for gingival hemorrhage and damage; Calamina then is the effect that the skin that festers is had the convergence granulation promoting.Above ratio is determined by lot of experiments, has considered simultaneously therapeutic effect and the factor of making toothpaste stability.
In the Chinese medicine composition of above-mentioned anti-sensitivity of tooth, Fructus Piperis Longi can be Fructus Piperis Longi powder, other form of Fructus Piperis Longi oil and Fructus Piperis Longi, and preferred Fructus Piperis Longi powder, preferred weight percent is 45-60%; If select Fructus Piperis Longi powder, fineness is more than 200 orders, if adopt Fructus Piperis Longi oil, then content of piperine should be 50～65%.
In the Chinese medicine composition of above-mentioned anti-sensitivity of tooth, Radix Notoginseng can be Radix Notoginseng powder, other form of arasaponin and Radix Notoginseng, and preferred arasaponin, preferred weight percent is 45-60%; If select Radix Notoginseng powder, fineness is more than 200 orders, if adopt the Radix Notoginseng extracting solution, then arasaponin content should be more than 50%.
In the Chinese medicine composition of above-mentioned anti-sensitivity of tooth, Flos Lonicerae extract can be Flos Lonicerae extractive solution, other form of Flos Lonicerae extractum and Flos Lonicerae, and preferred Flos Lonicerae extractive solution, preferred weight percent is 7-30%; If select Flos Lonicerae extractive solution, chlorogenic acid content wherein should be 30～50%, if adopt Flos Lonicerae extractum, then chlorogenic acid content should be more than 30%.
In the Chinese medicine composition of above-mentioned anti-sensitivity of tooth, Calamina can preferably not forge through forging or not forging, and preferred weight percent is 5-15%; No matter the Calamina that adopts forges is not still forged, and fineness all should be more than 200 orders.
The Chinese medicine composition of above-mentioned anti-sensitivity of tooth of the present invention screens plurality of Chinese according to performances such as Chinese medicines " four gas, the five tastes; seven emotions ", the property of medicine according to screening of medicaments is carried out compatibility and experiment by the principle of " mutual reinforcement between, the mutual-assistance, mutual restraint between two drugs, the mutual-detoxication, the mutual inhibition ", and the mutual compatibility principle of complementarity of plant source medicinal and mineral source medicine has been researched and developed can have the Chinese medicine composition of curative effect of medication in oral care product.This Chinese medicine composition can just can play preferably anti-sensitivity of tooth effect by simple daily use, and dental haemorrhage, various focusing depths represented are swollen and ache etc. has certain effect simultaneously.
The Fructus Piperis Longi that the present invention adopts is that the Piperaceae Piper is climbed up by holding on to the shape liana, and its main component is piperine, Palmic acid, tetrahydropiperic acid, piperidines, volatile oil, N-isobutyl group decadinene, amide etc.The Fructus Piperis Longi warming spleen and stomach for dispelling cold, the common medicine for the treatment of interior cold disease.Fructus Piperis Longi is the immaturity fruit ear of Piperaceae plant Fructus Piperis Longi, and a species specific fragrance is arranged, and acrid in the mouth is peppery.Fructus Piperis Longi is in the news to have at analgesia, calmness, antiinflammatory, convulsion etc. has preferably effect be widely used.Radix Notoginseng contains Saponin, is mainly ginsenoside Rb1, Rg1, Rg2 and a small amount of ginsenoside Ra, Rb2, Rb and Re.In addition, still contain flavonoid glycoside, starch, protein, oils and fats etc.Nature and flavor: warm in nature, sweet in the mouth, little hardship.Compendium of Material Medica cloud: " Radix Notoginseng hemostasis, loose blood, analgesic therapy." Radix Notoginseng eats something rare, eliminating blood stasis to promote regeneration of blood, subduing swelling and relieving pain, and have hemostasis not stay blood stasis, stronger analgesia, anti-inflammatory effect are arranged.Flos Lonicerae has another name called Radix Ophiopogonis, is the perennial half evergreen winding bejuco of Caprifoliaceae.The sweet cold of its property fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, also kind removing summer-heat blood poison.Calamina is carbonate mineral calcite family smithsonite, and the master contains zinc carbonate, and property is sweet, warm, nontoxic.Be widely used in department of dermatologry, as anticorrosion, convergence, protective agent treatment scytitis or the surface injury of moderate, external can suppress local aureus growth.
Above-mentioned anti-sensitivity of tooth Chinese medicinal components can apply on the toothpaste, comprise wetting agent, abrasivus, binding agent, surfactant, sweeting agent, essence, antiseptic and water in the toothpaste component, it is characterized in that: the drug composition in the anti-sensitivity of tooth in toothpaste with the mastic ratio is by weight percentage:
Mastic 90～99.9%, anti-sensitivity of tooth Chinese medicine composition 0.1～10%.
The optimal percentage by weight of anti-sensitivity of tooth Chinese medicine composition is 0.5～5%;
The lotion of toothpaste manufacture method of above-mentioned prescription is: add wetting agent, add again binding agent rapid stirring homogenizing, successively add sweeting agent, etc. additive, add again the anti-sensitivity of tooth Chinese medicinal components that configures, foaming agent and antiseptic, and uniform stirring; Then evacuation adds abrasivus, stirs homogenizing, adds at last essence, stirs homogenizing, and degassed, mastic preparation is finished.
Toothpaste is considered the most applicable oral-cavity article of technical solution of the present invention, but the present invention has more than to be limited to and be added in a kind of oral-cavity article of toothpaste, and is applicable too at other oral-cavity articles such as collutory, dentifrice, tooth gel, chewing gum.
The specific embodiment
Technique effect of the present invention can further specify by embodiment.
Embodiment 1 contains preparation and the control experiment of anti-sensitivity of tooth Chinese medicinal components toothpaste
Table 1 Example formulations table
Wherein, the optimization proportioning of the Chinese medicinal components of III group is as follows:
Fructus Piperis Longi 20-40%,
Radix Notoginseng 20-40%
Calamina 10-20%
Flos Lonicerae extract 5-20%
The manufacture method of the toothpaste of above-mentioned prescription is: glycerol, sorbitol, water are mixed, add successively again saccharin sodium, sodium benzoate, carboxymethyl cellulose, sodium lauryl sulphate, thickening type silicon dioxide, the rapid stirring homogenizing, add again the anti-sensitivity of tooth Chinese medicinal components that configures, add friction-type silicon dioxide and stir homogenizing, evacuation adds essence at last, stir homogenizing, degassed, mastic preparation is finished.Toothpaste is considered the most applicable oral-cavity article of technical solution of the present invention, but the present invention has more than to be limited to and be added in a kind of oral-cavity article of toothpaste, and other oral-cavity articles such as collutory, dentifrice, tooth gel, chewing gum are applicable too.
Four groups of toothpaste shown in the his-and-hers watches 1 carry out antiallergic sense clinical trial, take the double-blind trial method, choose at random 90 patients that suffer from sensitivity of tooth, are divided into equal three groups.The toothpaste that they (brush teeth twice) on the basis of daily habits and organize with I, II, III respectively every day continues to use three months.Result of the test sees Table 2.
Table 2 result of the test
Result of the test shows that the result of test group II and blank assay group I does not have significant difference, and the test group III and the front two groups of results that have added anti-sensitivity of tooth Chinese medicine composition have significant difference, antiallergic sense successful.From interpretation of result, although Fructus Piperis Longi all has the effect of relieving the pain to toothache in various reading up the literature, test discovery through us, this effect is at this of short duration administering mode, as brushes teeth, effect and not obvious in the process of gargling.And find simultaneously that at the experimentation of test group III the personnel oral cavity state that takes one's test has obvious improvement, when alleviating sensitivity of tooth the curative effect gingival hemorrhage also arranged preferably, the phenomenon such as root of the tooth redness has obvious minimizing.We think it may is because the performance of the mutual reinforcement between between the component, mutually auxiliary effect raising curative effect of medication.
Embodiment 2 contains the preparation of the dentifrice of anti-sensitivity of tooth Chinese medicinal components:
Various raw material constituent ratios are as follows:
Calcium carbonate 60-75%
Sodium bicarbonate 5-10%,
Sodium lauryl sulphate 8-10%
Saccharin sodium 0.2-1%
Natural menthol 1-1.5%
The smart 0.5-1% of Herba Menthae powder
The Chinese medicine composition 5-10% of anti-sensitivity of tooth
The proportioning of the Chinese medicine composition of anti-sensitivity of tooth is as follows:
Fructus Piperis Longi 40-50%,
Radix Notoginseng 20-50%
Calamina 5-10%
Flos Lonicerae extract 5-20%
Compound method is as follows: at first, calcium carbonate, sodium bicarbonate, saccharin sodium, Herba Menthae powder essence, Natural menthol are ground to form fine powder and cross 250 mesh sieves, after again Fructus Piperis Longi, Radix Notoginseng, Calamina, Flos Lonicerae extract being made powder and crossing 300 mesh sieves, with aforementioned mixture and sodium lauryl sulphate mix homogeneously, at last, every part of 10g-50g of packing.
Claims (9)
1. the Chinese medicine composition of an anti-sensitivity of tooth, composed of the following components by weight percentage:
Fructus Piperis Longi powder or Fructus Piperis Longi oil 20～70%, Radix Notoginseng powder or Radix Notoginseng extract 20～70%, Flos Lonicerae extract 5～50%, Calamina 2～20%.
2. the Chinese medicine composition of anti-sensitivity of tooth according to claim 1, it is characterized in that: in the Chinese medicine composition of described anti-sensitivity of tooth, when selecting Fructus Piperis Longi powder, the fineness of Fructus Piperis Longi powder is more than 200 orders, when selecting Fructus Piperis Longi oil, then the content of piperine in the Fructus Piperis Longi oil is 50～65%.
3. the Chinese medicine composition of anti-sensitivity of tooth according to claim 1, it is characterized in that: in the Chinese medicine composition of described anti-sensitivity of tooth, when selecting Radix Notoginseng powder, the Radix Notoginseng powder fineness is more than 200 orders; When selecting Radix Notoginseng extract, the arasaponin content in the extract should be more than 50%.
4. the Chinese medicine composition of anti-sensitivity of tooth according to claim 1, it is characterized in that: in the Chinese medicine composition of described anti-sensitivity of tooth, Flos Lonicerae extract is selected from Flos Lonicerae extractive solution or Flos Lonicerae extractum, when selecting Flos Lonicerae extractive solution, percentage ratio in Chinese medicine composition is 7～30%, and the chlorogenic acid content in the Flos Lonicerae extractive solution should be 30～50%; When selecting Flos Lonicerae extractum, the extractum Content of Chlorogenic Acid should be more than 30%.
5. the Chinese medicine composition of anti-sensitivity of tooth according to claim 1, it is characterized in that: in the Chinese medicine composition of described anti-sensitivity of tooth, Calamina is through forging or not forging, and no matter the Calamina that adopts forges is not still forged, and fineness is all answered more than 200 orders.
6. Chinese medicine composition toothpaste that contains anti-sensitivity of tooth, comprise wetting agent, abrasivus, binding agent, surfactant, sweeting agent, essence, antiseptic and water in the lotion of toothpaste component, it is characterized in that also comprising in the toothpaste Chinese medicine composition of anti-sensitivity of tooth, by weight percentage:
The Chinese medicine composition 0.1～10% of mastic 90～99.9%, anti-sensitivity of tooth;
Wherein, in the Chinese medicine composition of described anti-sensitivity of tooth by weight percentage: Fructus Piperis Longi powder Huo Fructus Piperis Longi oil 20～70%, Radix Notoginseng powder or Radix Notoginseng extract 20%～70%, Flos Lonicerae extract 5～50%, Calamina 2～20%;
In the Chinese medicine composition of described anti-sensitivity of tooth, when selecting Fructus Piperis Longi powder, the fineness of Fructus Piperis Longi powder is more than 200 orders; When selecting Fructus Piperis Longi oil, the content of piperine in the Fructus Piperis Longi oil is 50～65%;
In the Chinese medicine composition of described anti-sensitivity of tooth, when selecting Radix Notoginseng powder, the Radix Notoginseng powder fineness is more than 200 orders; When selecting Radix Notoginseng extract, the arasaponin content in the extract is greater than 50%;
In the Chinese medicine composition of described anti-sensitivity of tooth, Flos Lonicerae extract is selected from Flos Lonicerae extractive solution or Flos Lonicerae extractum, when selecting Flos Lonicerae extractive solution, the percentage by weight in Chinese medicine composition is 7～30%, and the chlorogenic acid content in the Flos Lonicerae extractive solution should be 30～50%; When selecting Flos Lonicerae extractum, the chlorogenic acid content in the extractum is greater than 30%;
In the Chinese medicine composition of described anti-sensitivity of tooth, Calamina is through forging or not forging, and no matter the Calamina that adopts forges is not still forged, and fineness all should be more than 200 orders.
7. the Chinese medicine composition toothpaste of a kind of anti-sensitivity of tooth according to claim 6, it is characterized in that: the percentage by weight of the Chinese medicine composition of anti-sensitivity of tooth in toothpaste counts 0.5～5%.
8. method for preparing the Chinese medicine composition toothpaste of anti-sensitivity of tooth as claimed in claim 6, it is characterized in that: add wetting agent, add again binding agent stir homogenizing after, add sweeting agent and other additive successively, add again the anti-sensitivity of tooth Chinese medicine composition for preparing, foaming agent and antiseptic, and uniform stirring; Then evacuation adds abrasivus, stirs homogenizing, adds at last essence, stirs homogenizing, and degassed, mastic preparation is finished.
9. the application of the Chinese medicine composition of the described anti-sensitivity of tooth of claim 1 in the preparation oral care implement, described oral care product comprises collutory, dentifrice, tooth gel and chewing gum.
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102784209B (en) * | 2012-08-10 | 2014-12-17 | 重庆登康口腔护理用品股份有限公司 | Traditional Chinese medicine composition for preventing and treating tooth sensitivity, toothpaste and preparation method thereof |
| CN104207973A (en) * | 2014-07-26 | 2014-12-17 | 安顺学院 | Method for preparing toothpaste from extract of leaves of sweet potato |
| CN104248571A (en) * | 2014-09-19 | 2014-12-31 | 云南七丹药业股份有限公司 | Purely natural plant-containing abradant toothpaste and preparation method thereof |
| CN104522279A (en) * | 2015-01-30 | 2015-04-22 | 云南省药物研究所 | Chewing gum containing total saponin of panax notoginseng and preparation method thereof |
| CN104644502A (en) * | 2015-02-09 | 2015-05-27 | 福建美力生生物科技股份有限公司 | Camellia oil toothpaste formula and application of camellia oil in preparing toothpastes |
| CN107213073A (en) * | 2017-07-06 | 2017-09-29 | 李明劲 | A kind of toothpaste containing notoginseng glycol saponin and preparation method thereof |
| CN107714569A (en) * | 2017-12-07 | 2018-02-23 | 威海职业学院 | A kind of preparation method of fragrant plant mouthwash |
| CN108324611A (en) * | 2018-03-26 | 2018-07-27 | 天马（安徽）国药科技股份有限公司 | A kind of herbal medicine Radix Notoginseng whitening toothpaste |
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