CN107213073A - A kind of toothpaste containing notoginseng glycol saponin and preparation method thereof - Google Patents
A kind of toothpaste containing notoginseng glycol saponin and preparation method thereof Download PDFInfo
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- CN107213073A CN107213073A CN201710548068.7A CN201710548068A CN107213073A CN 107213073 A CN107213073 A CN 107213073A CN 201710548068 A CN201710548068 A CN 201710548068A CN 107213073 A CN107213073 A CN 107213073A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses a kind of toothpaste containing notoginseng glycol saponin and preparation method thereof.Notoginseng glycol saponin dentifrice composition of the present invention, it includes the component of following weight proportion：(70%) 90 130 part of sorbierite, 5 15 parts of glycerine, 5 25 parts of silica 1,6 12 parts of thickener, 25 parts of sldium lauryl sulfate, 0.5 1.5 parts of notoginseng glycol saponin, 15 25 parts of pure water.The invention also discloses the preparation method of notoginseng glycol saponin dentifrice composition and purposes.Notoginseng glycol saponin toothpaste of the present invention has effects that obvious swelling and pain relieving, hemostasis, anti-inflammatory, available for periodontitis, gingivitis, bleeding gums, swelling and aching of gum prevention, permanent tooth shield gum, mitigate suffering from oral disease pain；Toothpaste has pure and fresh smell simultaneously, is easily esthetically acceptable to the consumers.
Description
Technical field
It, on a kind of toothpaste, is specifically on a kind of toothpaste containing notoginseng glycol saponin composition and the toothpaste that the present invention, which is,
Preparation method.
Background technology
Toothpaste is the cleaning supplies commonly used in daily life, to the healthy extremely important of protection oral cavity.Toothpaste is by powdery
What rubbing agent, lubricant, surfactant, binder, spices, sweetener and other special compositions were constituted.Chinese medicine is gone through in China
History is long, of long standing and well established.Back to nature is being pursued, is being advocated natural today, increasing enterprise adds traditional ancient prescription Chinese traditional medicine
Enter toothpaste, brushed teeth by daily, consciously playing prevents hemodia pain, control gingivitis and bleeding, auxiliary are brightened except stain,
Canker sore, prevention and reduction mouth disease are prevented, promotes the purpose of oral health.
Pseudo-ginseng (Panaxnotoginseng (Burk.) F.H.Chen) is the dry root of panax araliaceae plant, its property is sweet,
Slight bitter, temperature, effect with " removing blood stasis and hemostasis, detumescence ding-tong ".It is separated to 70 various of monomer from the different parts of pseudo-ginseng at present
Saponin(e, arasaponin is pseudo-ginseng main active, can be divided into notoginseng glycol saponin and notoginseng triol-saponin.However, pseudo-ginseng
The pharmacological action of each composition in total saposins respectively has weighting, and (main component is ginsenoside Rb to notoginseng glycol saponin1And it is a small amount of
Rb2、Rc、Rd) " detumescence, analgesia, anti-inflammatory " effect have more obvious advantage than arasaponin and notoginseng triol-saponin.By
There is the effect of inhibiting bacteria and diminishing inflammation in saponin(e, therefore saponins toothpaste is more universal in the market, such as " pseudo-ginseng ", " Milan ", " three
Seven ", " ginseng " toothpaste.They show in terms of help eliminates toothache, fresh breath, extenuates gum redness, improvement oral problem
Good effect is shown, but these toothpaste often have strong Chinese medicine odor, easily cause vomiting stimulation when using, no
Easily it is esthetically acceptable to the consumers.
CN201210107911.5 discloses a kind of panax notoginseng medicinal toothpaste, wherein being the total soap of the pseudo-ginseng that will be extracted in pseudo-ginseng
Glycosides, notoginseng glycol saponin, notoginseng triol, Radix Angelicae Sinensis, bupleurum extract are key agents activated feedstock, are equipped with and prepare the conventional of toothpaste
Auxiliary material and common process, be prepared into it is a kind of have nutrition tooth, take care of one's teeth, tooth-whitening, cleaning tooth it is dirty, firm tooth bright
Aobvious effect, peppermint is light, and it is pure and fresh that long-term use can continue ability to speak.The toothpaste selects various medicinal material, and traditional Chinese medicine ingredients are various, medicine
Thing proportioning combination with reach tooth whitening, cleaning and protection effect, detumescence, analgesia, anti-inflammatory effect it is weaker.
The content of the invention
It is an object of the present invention to provide it is a kind of with swelling and pain relieving, hemostasis, anti-inflammatory effect notoginseng glycol saponin
Dentifrice composition and its production and use.
The invention provides a kind of notoginseng glycol saponin dentifrice composition, it includes the component of following weight proportion：
The notoginseng glycol saponin is prepared in accordance with the following methods：Pseudo-ginseng is taken to crush a sieve, plus concentration is
60% ethanol soaks, diacolation, collects percolate；Percolate is concentrated under reduced pressure, ethanol is reclaimed；Concentrate is diluted with distilled water,
It is added slowly in macroporous absorbent resin splitter, successively with distilled water, 40% ethanol and 60% ethanol elution, collects 60% ethanol
Eluent；60% ethanol eluate is through being concentrated under reduced pressure into the diol saponin crude product solution that relative density is 1.10；Diol saponin is thick
Product solution admixes silica gel, fully mixes, is dried under reduced pressure, must mix sample silica gel；Sample silica gel will be mixed to be fitted into the chromatographic column of 23 times of silica gel,
Eluted, checked with silica G plate with the mixed solvent containing ethyl acetate, second alcohol and water, collect R containing ginsenosideb1、RdThe stream of composition
Part；Eluent is filtered, and filtrate decompression is concentrated into the liquid extract of relative density 1.33；Liquid extract is dried under reduced pressure, and obtains dry extract, by dry leaching
Cream is crushed, and produces the notoginseng glycol saponin of light yellowish brown powder.
Preferably, the ratio between the raw material and macroporous absorbent resin are 10: 1, and/or the post footpath of macroporous absorbent resin and pillar height
The ratio between be：30∶160；
And/or, macroporous absorbent resin is styrene type EVA, model D-101；
And/or, macroporous absorbent resin splitter is processed balanced；
And/or, in addition to used macroporous absorbent resin splitter is rinsed with 1% hydrochloride ethanol liquid, gradually reduce
Concentration of alcohol is eluted, until with distilled water flushing to neutrality, you can reuse；
And/or, in addition to by used silica gel, it is colourless to be eluted to efflux with distilled water, takes out silica gel baking, baking oven
When temperature rises to 120 ± 2 DEG C, stop heating, natural cooling is that can be used；
And/or, temperature is concentrated under reduced pressure or is dried under reduced pressure for 50 ± 5 DEG C；And/or the notoginseng glycol saponin extracted contains three
Whole glycol saponins in seven, wherein ginsenoside Rg1Content is not less than 56%, RdContent is not less than 12%, and the two is added up to
68-88%；
And/or, organic solvent residual thing content benzene is less than 2ppm, toluene, dimethylbenzene and divinyl in notoginseng glycol saponin
Benzene is respectively less than 20ppm.
Wherein, described thickener is sodium carboxymethylcellulose.
Wherein, the toothpaste also includes the essence of 0.9-2.7 parts by weight.
Wherein, the toothpaste also includes the saccharin of 0.09-0.27 parts by weight.
In the formulation of tooth-paste of the present invention, sorbierite, glycerine are as NMF and each other index of refraction conditioning agents；Silica
It is used as rubbing agent；Sodium carboxymethylcellulose is thickener, has certain effect to molding effect；Sldium lauryl sulfate is used as foaming
Agent.
According to specific embodiments of the present invention, in formulation of tooth-paste of the present invention, essence, saccharin etc. can be also further added with
Flavouring composition.Specifically, the addition of the essence is usually the 0.9-2.7% of toothpaste gross mass, and the addition of saccharin leads to
It is often the 0.09-0.27% of toothpaste gross mass.
Present invention also offers the preparation method of the notoginseng glycol saponin toothpaste, this method includes：
Sodium carboxymethylcellulose (CMC) is added in glycerine, glycerin cement is made, it is standby.By notoginseng glycol saponin (as being formulated
In contain saccharin, first saccharin is added in notoginseng glycol saponin) mixed with glycerin cement, and stir, obtain equal compound I.Then
Sorbierite, liquid sldium lauryl sulfate (K12) (homogeneous mixture of K12 and pure water) are added in equal compound I, stirring is equal
It is even, obtain equal compound II.Silica is added in equal compound II, is evenly stirred until transparent, equal compound III is obtained.Contain in being such as formulated
There is essence, add essence in equal compound III, stir, obtain lotion of toothpaste.It is filling to get product notoginseng glycol saponin tooth
Cream.
According to the proportioning between each component in the toothpaste of the present invention, the toothpaste can be made to a kind of lotion of transparence.Its
In, the index of refraction of rubbing agent (silica) of the toothpaste liquid phase index of refraction constituted with water, glycerine, sorbierite with adding is basic
Equal (ratio of sorbierite, glycerine, silica can be determined during specific implementation by using refractometer, carry out toothpaste preparation), cream
Good pellucidity is presented in body.
Present invention also offers use of the foregoing dentifrice composition in swelling and pain relieving, hemostasis and/or the toothpaste of anti-inflammatory is prepared
On the way.
Pre- preventing parodontitis, gingivitis, bleeding gums, swelling and aching of gum are being prepared present invention also offers foregoing dentifrice composition
Toothpaste in purposes.
Notoginseng glycol saponin toothpaste of the present invention has effects that obvious swelling and pain relieving, hemostasis, anti-inflammatory, available for periodontal
Inflammation, gingivitis, bleeding gums, the prevention of swelling and aching of gum, permanent tooth shield gum, mitigate suffering from oral disease pain；Simultaneously only with one
The most effective composition of a class of taste Chinese medicine, it is to avoid the smell of traditional Chinese medicine so that toothpaste has pure and fresh smell, reduces toothpaste and causes
Vomiting stimulate, be easily esthetically acceptable to the consumers.
Obviously, according to the above of the present invention, according to the ordinary technical knowledge and customary means of this area, do not departing from
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification of other diversified forms can also be made, replaces or changes.
The embodiment of form, remakes further specifically to the above of the invention by the following examples
It is bright.But the scope that this should not be interpreted as to above-mentioned theme of the invention is only limitted to following example.It is all to be based on the above of the present invention
The technology realized belongs to the scope of the present invention.
Embodiment
The preparation of the notoginseng glycol saponin toothpaste of the present invention of embodiment 1
Formulation of tooth-paste：
Sorbierite (70%), glycerine, silica, sodium carboxymethylcellulose, sldium lauryl sulfate, essence, saccharin pass through
The mode of purchase is obtained.
Wherein, the notoginseng glycol saponin is prepared in accordance with the following methods：
100 grams of pseudo-ginseng are taken to crush a sieve, plus the ethanol that concentration is 60% soaks, diacolation, collects percolate；Percolate
It is concentrated under reduced pressure, temperature is 50 DEG C, reclaims ethanol；Concentrate is diluted to 500-600 milliliters with distilled water, is added slowly to macroporous absorption
(the ratio between post footpath and pillar height are resin separating column：30: 160, built with 100 milliliters of D101 resins) in, successively with 500 milliliters of distillations
Water, 1000 milliliter of 40% ethanol and 1000 milliliter of 60% ethanol elution, flow velocity are 0.5 times of bed volume/hour, collect 60% ethanol
Eluent；60% ethanol eluate is molten through being concentrated under reduced pressure into the diol saponin crude product that relative density is 1.10 when temperature is 50 DEG C
Liquid；Diol saponin crude product solution is admixed in silica gel (conventional method and ratio), is fully mixed, is dried under reduced pressure, sample silica gel must be mixed；
Sample silica gel will be mixed to be fitted into 23 times of silicagel columns, with 600-800 milliliters of mixed solvent (three's ratios containing ethyl acetate, second alcohol and water
Example be：1: 1: 10) elute, checked with silica G plate, collect R containing ginsenosideb1、RdDeng the stream part of composition；Eluent is filtered, filter
Liquid be concentrated under reduced pressure when temperature is 50 DEG C relative density be 1.33 liquid extract；Liquid extract is dried under reduced pressure, dry extract is obtained, will
Dry extract is crushed, and produces about 2.15 grams of the notoginseng glycol saponin of light yellowish brown powder；Macroporous absorbent resin regenerates：It will use
Macroporous absorbent resin splitter with 1% hydrochloride ethanol liquid soak 12-24 hour, gradually reduce concentration of alcohol elute, finally use
Distilled water flushing is to neutrality；Post layer silica regeneration step：By used silica gel, it is colourless to be eluted to efflux with distilled water, takes
Go out silica gel baking, when oven temperature rises to 120 ± 2 DEG C, stop heating, natural cooling is that can be used.
The notoginseng glycol saponin toothpaste preparation method of the present embodiment is：CMC is added in glycerine, glycerin cement is made, it is standby.
Saccharin is added in notoginseng glycol saponin, then mixed with glycerin cement, and stir (mixing of physics, no chemical reaction, machine
Tool formula is stirred, and agitating mode is more, as long as effect reaches, temperature is at 20 ± 5 DEG C), obtain equal compound I.Then by sorbierite, liquid
Body sldium lauryl sulfate (homogeneous mixture of sldium lauryl sulfate (K12) and pure water) is added in equal compound I, is stirred,
Obtain equal compound II.Silica is added in equal compound II, is evenly stirred until transparent, equal compound III is obtained.Then at equal compound III
Middle addition essence, stirs, and is added to cream processed in vacuum Manufacturing medicine extract machine, produces notoginseng glycol saponin toothpaste.
The preparation of the notoginseng glycol saponin toothpaste of the present invention of embodiment 2
Formulation of tooth-paste：
Sorbierite (70%) 90g
Glycerine 15g
Silica 1 5g
Sodium carboxymethylcellulose 12g
Sldium lauryl sulfate 2g
Essence 2g
Saccharin 0.2g
Notoginseng glycol saponin 1.5g
Pure water 15g
Wherein, the notoginseng glycol saponin is prepared in accordance with the following methods：
100 grams of pseudo-ginseng are taken to crush a sieve, plus the ethanol that concentration is 60% soaks, diacolation, collects percolate；Percolate
It is concentrated under reduced pressure, temperature is 50 DEG C, reclaims ethanol；Concentrate is diluted to 500-600 milliliters with distilled water, is added slowly to macroporous absorption
(the ratio between post footpath and pillar height are resin separating column：30: 160, built with 100 milliliters of D101 resins) in, successively with 500 milliliters of distillations
Water, 1000 milliliter of 40% ethanol and 1000 milliliter of 60% ethanol elution, flow velocity are 0.5 times of bed volume/hour, collect 60% ethanol
Eluent；60% ethanol eluate is molten through being concentrated under reduced pressure into the diol saponin crude product that relative density is 1.10 when temperature is 50 DEG C
Liquid；Diol saponin crude product solution is admixed in silica gel (conventional method and ratio), is fully mixed, is dried under reduced pressure, sample silica gel must be mixed；
Sample silica gel will be mixed to be fitted into 23 times of silicagel columns, with 600-800 milliliters of mixed solvent (three's ratios containing ethyl acetate, second alcohol and water
Example be：1: 1: 10) elute, checked with silica G plate, collect R containing ginsenosideb1、RdDeng the stream part of composition；Eluent is filtered, filter
Liquid be concentrated under reduced pressure when temperature is 50 DEG C relative density be 1.33 liquid extract；Liquid extract is dried under reduced pressure, dry extract is obtained, will
Dry extract is crushed, and produces about 2.15 grams of the notoginseng glycol saponin of light yellowish brown powder；Macroporous absorbent resin regenerates：It will use
Macroporous absorbent resin splitter with 1% hydrochloride ethanol liquid soak 12-24 hour, gradually reduce concentration of alcohol elute, finally use
Distilled water flushing is to neutrality；Post layer silica regeneration step：By used silica gel, it is colourless to be eluted to efflux with distilled water, takes
Go out silica gel baking, when oven temperature rises to 120 ± 2 DEG C, stop heating, natural cooling is that can be used.
The notoginseng glycol saponin toothpaste preparation method of the present embodiment is：CMC is added in glycerine, glycerin cement is made, it is standby.
Saccharin is added in notoginseng glycol saponin, then mixed with glycerin cement, and stir (mixing of physics, no chemical reaction, machine
Tool formula is stirred, and agitating mode is more, as long as effect reaches, temperature is at 20 ± 5 DEG C), obtain equal compound I.Then by sorbierite, liquid
Body sldium lauryl sulfate (homogeneous mixture of sldium lauryl sulfate (K12) and pure water) is added in equal compound I, is stirred,
Obtain equal compound II.Silica is added in equal compound II, is evenly stirred until transparent, equal compound III is obtained.Then at equal compound III
Middle addition essence, stirs, and is added to cream processed in vacuum Manufacturing medicine extract machine, produces notoginseng glycol saponin toothpaste.
The preparation of the notoginseng glycol saponin toothpaste of the present invention of embodiment 3
Formulation of tooth-paste：
Sorbierite (70%) 130g
Glycerine 5g
Silica 25g
Sodium carboxymethylcellulose 6g
Sldium lauryl sulfate 5g
Essence 2g
Saccharin 0.25g
Notoginseng glycol saponin 0.5g
Pure water 25g
Wherein, the notoginseng glycol saponin is prepared in accordance with the following methods：
100 grams of pseudo-ginseng are taken to crush a sieve, plus the ethanol that concentration is 60% soaks, diacolation, collects percolate；Percolate
It is concentrated under reduced pressure, temperature is 50 DEG C, reclaims ethanol；Concentrate is diluted to 500-600 milliliters with distilled water, is added slowly to macroporous absorption
(the ratio between post footpath and pillar height are resin separating column：30: 160, built with 100 milliliters of D101 resins) in, successively with 500 milliliters of distillations
Water, 1000 milliliter of 40% ethanol and 1000 milliliter of 60% ethanol elution, flow velocity are 0.5 times of bed volume/hour, collect 60% ethanol
Eluent；60% ethanol eluate is molten through being concentrated under reduced pressure into the diol saponin crude product that relative density is 1.10 when temperature is 50 DEG C
Liquid；Diol saponin crude product solution is admixed in silica gel (conventional method and ratio), is fully mixed, is dried under reduced pressure, sample silica gel must be mixed；
Sample silica gel will be mixed to be fitted into 23 times of silicagel columns, with 600-800 milliliters of mixed solvent (three's ratios containing ethyl acetate, second alcohol and water
Example be：1: 1: 10) elute, checked with silica G plate, collect R containing ginsenosideb1、RdDeng the stream part of composition；Eluent is filtered, filter
Liquid be concentrated under reduced pressure when temperature is 50 DEG C relative density be 1.33 liquid extract；Liquid extract is dried under reduced pressure, dry extract is obtained, will
Dry extract is crushed, and produces about 2.15 grams of the notoginseng glycol saponin of light yellowish brown powder；Macroporous absorbent resin regenerates：It will use
Macroporous absorbent resin splitter with 1% hydrochloride ethanol liquid soak 12-24 hour, gradually reduce concentration of alcohol elute, finally use
Distilled water flushing is to neutrality；Post layer silica regeneration step：By used silica gel, it is colourless to be eluted to efflux with distilled water, takes
Go out silica gel baking, when oven temperature rises to 120 ± 2 DEG C, stop heating, natural cooling is that can be used.
The notoginseng glycol saponin toothpaste preparation method of the present embodiment is：CMC is added in glycerine, glycerin cement is made, it is standby.
Saccharin is added in notoginseng glycol saponin, then mixed with glycerin cement, and stir (mixing of physics, no chemical reaction, machine
Tool formula is stirred, and agitating mode is more, as long as effect reaches, temperature is at 20 ± 5 DEG C), obtain equal compound I.Then by sorbierite, liquid
Body sldium lauryl sulfate (homogeneous mixture of sldium lauryl sulfate (K12) and pure water) is added in equal compound I, is stirred,
Obtain equal compound II.Silica is added in equal compound II, is evenly stirred until transparent, equal compound III is obtained.Then at equal compound III
Middle addition essence, stirs, and is added to cream processed in vacuum Manufacturing medicine extract machine, produces notoginseng glycol saponin toothpaste.
Beneficial effects of the present invention are proved below by way of specific clinical observation：
The notoginseng glycol saponin toothpaste of the present invention of test example 1 is to oral disease therapeutic and the checking of prevention
1 material
1.1 are prepared by test product notoginseng glycol saponin toothpaste of the present invention according to embodiment 1.
1.2 patient datas observe case totally 411：Gingivitis 101, periodontitis 97, bleeding gums 105, gum
Swell and ache 108.
2 methods
2.1 notoginseng glycol saponin toothpaste of the present invention are observed by following clinical, 2 weeks experimental periods, daily early during experiment
Late normal brush teeth uses, each subject oral cavity disease condition before and after observation experiment.
3 results
3.1 swelling and aching of gum, gingivitis, bleeding gums, Treatment in Patients with Periodontitis situation
As a result such as table 1：
Table 1：Swelling and aching of gum, gingivitis, bleeding gums, Treatment in Patients with Periodontitis situation
As a result such as upper table：As can be seen from the above table, notoginseng diol toothpaste of the invention has swelling and pain relieving, hemostasis, anti-inflammatory
The effects such as.Mouth disease is to endanger one of principal disease of human health.The mouth disease of early stage be usually associated with swelling and aching of gum,
The symptoms such as bleeding, the use of notoginseng diol toothpaste not only keeps oral cleaning, can also prevent mouth disease, promotes the strong of tooth
Health.
The investigation of the notoginseng glycol saponin toothpaste taste acceptance of the present invention of test example 2
1 material
1.1 notoginseng glycol saponin toothpaste of the present invention, mica filled polypropylene, the pseudo-ginseng teeth prepared by test product according to embodiment 1
Cream, Pien Tze Huang toothpaste, Chloranthus glaber toothpaste.
1.2 participation investigators randomly select 10 people and participate in investigation.
2 methods
2.1 prepare notoginseng glycol saponin toothpaste according to the method for embodiment 1, and buy in supermarket Yunnan Baiyao, pseudo-ginseng,
Pien Tze Huang, four kinds of medicated toothpaste of Chloranthus glaber, are repacked and are numbered, and randomly select medicine of 10 people to 5 kinds of medicated toothpaste
The acceptance of thing smell is judged, wherein 3 points are complete receiving, 2 points are receiving reluctantly, and 1 point is to receive.
3 results
3.1 toothpaste smell acceptance investigations
As a result such as table 2：
Table 2：Toothpaste smell acceptance is investigated
As a result such as upper table：Notoginseng diol toothpaste is scored at 30 points, and the acceptance of its drug tastes is widely recognized, other
Several drugses toothpaste score is respectively 24,23,18,22, all because drug smell brings discomfort to consumer in various degree.
To sum up, notoginseng glycol saponin toothpaste of the present invention has effects that obvious swelling and pain relieving, hemostasis, anti-inflammatory, can be used for
Periodontitis, gingivitis, bleeding gums, the prevention of swelling and aching of gum, permanent tooth shield gum, mitigate suffering from oral disease pain；Only simultaneously
With a kind of most effective composition of a herb, it is to avoid the smell of traditional Chinese medicine so that toothpaste has pure and fresh smell, toothpaste is reduced
Caused vomiting is stimulated, and is easily esthetically acceptable to the consumers.
Claims (10)
1. a kind of notoginseng glycol saponin dentifrice composition, it is characterised in that：It includes the component of following weight proportion：
90-130 parts of sorbierite (70%)
5-15 parts of glycerine
5-25 parts of silica 1
6-12 parts of thickener
2-5 parts of sldium lauryl sulfate
0.5-1.5 parts of notoginseng glycol saponin
15-25 parts of pure water.
2. notoginseng glycol saponin dentifrice composition according to claim 1, it is characterised in that：The notoginseng glycol saponin is
Prepare in accordance with the following methods：
Pseudo-ginseng is taken to crush a sieve, plus the ethanol that concentration is 60% soaks, diacolation, collects percolate；Percolate is depressurized dense
Contracting, reclaims ethanol；Concentrate is diluted with distilled water, is added slowly in macroporous absorbent resin splitter, successively with distilled water, 40%
Ethanol and 60% ethanol elution, collect 60% ethanol eluate；60% ethanol eluate is through being concentrated under reduced pressure into relative density
1.10 diol saponin crude product solution；Diol saponin crude product solution admixes silica gel, fully mixes, is dried under reduced pressure, must mix sample silica gel；
Sample silica gel will be mixed to be fitted into the chromatographic column of 23 times of silica gel, eluted with the mixed solvent containing ethyl acetate, second alcohol and water, use silica G
Plate is checked, collects R containing ginsenosideb1、RdThe stream part of composition；Eluent is filtered, and filtrate decompression is concentrated into relative density 1.33 and flowed
Medicinal extract；Liquid extract is dried under reduced pressure, and obtains dry extract, and dry extract is crushed, and produces the notoginseng glycol saponin of light yellowish brown powder.
3. notoginseng glycol saponin dentifrice composition according to claim 2, it is characterised in that：
The ratio between the raw material and macroporous absorbent resin are 10: 1, and/or the ratio between post footpath and the pillar height of macroporous absorbent resin are：30∶
160；
And/or, macroporous absorbent resin is styrene type EVA, model D-101；
And/or, macroporous absorbent resin splitter is processed balanced；
And/or, in addition to used macroporous absorbent resin splitter is rinsed with 1% hydrochloride ethanol liquid, gradually reduce ethanol
Concentration is eluted, until with distilled water flushing to neutrality, you can reuse；
And/or, in addition to by used silica gel, it is colourless to be eluted to efflux with distilled water, takes out silica gel baking, oven temperature
When rising to 120 ± 2 DEG C, stop heating, natural cooling is that can be used；
And/or, temperature is concentrated under reduced pressure or is dried under reduced pressure for 50 ± 5 DEG C；And/or the notoginseng glycol saponin extracted is contained in pseudo-ginseng
Whole glycol saponins, wherein ginsenoside Rg1Content is not less than 56%, RdContent is not less than 12%, and the two adds up to 68-
88%；
And/or, organic solvent residual thing content-benzene is less than 2ppm in notoginseng glycol saponin, and toluene, dimethylbenzene and divinylbenzene are equal
Less than 20ppm.
4. notoginseng glycol saponin dentifrice composition according to claim 1, it is characterised in that：Described thickener is carboxylic first
Base sodium cellulosate.
5. notoginseng glycol saponin dentifrice composition according to claim 1, it is characterised in that：It also includes 0.9-2.7 weights
Measure the essence of part.
6. notoginseng glycol saponin dentifrice composition according to claim 1, it is characterised in that：It also includes 0.09-0.27
The saccharin of parts by weight.
7. the preparation method of any one of the claim 1-6 notoginseng glycol saponin toothpaste, it is characterised in that：Including following step
Suddenly：
(1) sodium carboxymethylcellulose is added in glycerine, glycerin cement is made, it is standby；
(2) only notoginseng glycol saponin is mixed with glycerin cement, and stirred, obtain equal compound I；
(3) homogeneous mixture of sorbierite, sldium lauryl sulfate and pure water is added in above-mentioned equal compound I, stirs, obtain
Equal compound II；
(4) silica is added in equal compound II, is evenly stirred until transparent, obtain lotion of toothpaste.
8. preparation method according to claim 7, it is characterised in that：Also include sugar in the notoginseng glycol saponin toothpaste
Essence, its preparation method is first to add saccharin in notoginseng glycol saponin, is then mixed with glycerin cement；
And/or, essence is also included in the notoginseng glycol saponin toothpaste, its preparation method is to be added to essence to add two
In the equal compound of silica and stir, obtain lotion of toothpaste.
9. the dentifrice composition described in claim 1-6 any one is in swelling and pain relieving, hemostasis and/or the toothpaste of anti-inflammatory is prepared
Purposes.
10. the dentifrice composition described in claim 1-6 any one is preparing pre- preventing parodontitis, gingivitis, bleeding gums, tooth
Purposes in the toothpaste that gum swells and ache.
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Cited By (1)
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| CN109646471A (en) * | 2019-01-22 | 2019-04-19 | 名臣健康用品股份有限公司 | A kind of activation notoginsenoside rich in rare ginsenoside is in the application prepared in oral care product |
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| CN102670442A (en) * | 2012-05-14 | 2012-09-19 | 云南云科药业有限公司 | Panax notoginseng active ingredient-containing medicinal toothpaste and preparation method and application thereof |
| CN105131070A (en) * | 2015-09-21 | 2015-12-09 | 成都艾比科生物科技有限公司 | Method for directly extracting panasadiol saponins from pseudo-ginseng |
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| CN101112376A (en) * | 2007-08-27 | 2008-01-30 | 喜巍 | Toothpaste for nursing cardiac and cerebral blood vessel |
| CN101933977A (en) * | 2010-09-30 | 2011-01-05 | 重庆登康口腔护理用品股份有限公司 | Traditional Chinese medicine composition against tooth sensitivity, toothpaste and preparation method thereof |
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